CN105456424A - Medicine composition for treating mouth and tongue sores - Google Patents
Medicine composition for treating mouth and tongue sores Download PDFInfo
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- CN105456424A CN105456424A CN201610016265.XA CN201610016265A CN105456424A CN 105456424 A CN105456424 A CN 105456424A CN 201610016265 A CN201610016265 A CN 201610016265A CN 105456424 A CN105456424 A CN 105456424A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a medicine composition for treating mouth and tongue sores. The medicine composition is mainly prepared from, by weight, 10-15 parts of chrysanthemum, 12-20 parts of platycodon grandiflorum, 3-6 parts of borneol, 9-12 parts of radix caulophylli, 10-15 parts of myrobalan, 9-12 parts of rhizoma cimicifugae, 10-20 parts of roots of kudzu vines, 6-9 parts of corydalis tuber, 6-9 parts of sculellaria barbata, 8-12 parts of root bark of the peony tree, 5-10 parts of Psychotria calocarpa Kurz and 8-16 parts of Artemisia anomala. The medicine composition has the effects of clearing away heat and toxic materials, nourishing yin, removing internal heat and relieving swelling and pain, has the advantages of becoming effective rapidly, being short in treatment course, high in curative ratio, stable in curative effect, capable of preventing relapse and the like, and is free of any toxic or side effect.
Description
Divisional application, original applying number 2014106311095, applying date 2014.11.12, the Chinese medicine composition of title treatment aphtha of the mouth and tongue and method for making.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and method for making for the treatment of aphtha of the mouth and tongue.
Background technology
Aphtha of the mouth and tongue, namely oral ulcer are ulcerative lesions common in the disease of cari oris mucosa, have the feature of cyclic recurrence.The commonly encountered diseases of primary disease is because having gastrointestinal dysfunction, nervous, direct stimulation, anaphylaxis, endocrine regulation, acute infectious disease, oral mucosa lesion or often eating the dry food etc. of pungent perfume (or spice).The cardinal symptom of primary disease is that circle or oval aphtha appear in oral mucosa repeatedly, can single-shot or the multiple any part at oral mucosa, has violent spontaneous pain, generally can spontaneous recovery at about 10 days.Local symptom is relatively more remarkable, and how not obvious General Symptoms is.Many at ulcerative stage during discovery primary disease, ulcer diameter 2-3 millimeter, the end, is shallow, neat in edge, there is blush around, ulcer surface yellow-white fibrinous exudate covers, and has violent to burn sample pain, meets the stimulation such as hot and cold, sour, salty and all makes pain increase the weight of, difficulty all felt by language, diet, continue to proceed to healing stage after 4-5 days, any cicatrix is not stayed in healing, but can recurrent exerbation.Be apt to occur in person between twenty and fifty, women is more than male.Primary disease is divided excess-fire, asthenic fire amphitypy by the traditional Chinese medical science, and the former shows as aversion to cold, heating, headache, constipation, yellow urine, the thick drying of yellow fur, and sometimes accompany the large pain of submandibular lymph nodes, the latter without obvious General Symptoms or can have low grade fever.Some are with dry mouth, and dry pharynx, the palm of the hand scald, insomnia, dreaminess, tongue fur peel off.Publication number CN101991699A(application number 201010537218.2) Chinese patent literature disclose a kind of Chinese medicine being used for the treatment of toothache due to stomach-fire, aphtha of the mouth and tongue, be made up of Rhizoma Coptidis, Rhizoma Cimicifugae, Gypsum Fibrosum, Cortex Moutan, the Radix Rehmanniae and Radix Glycyrrhizae.Publication number CN103285198A(application number 201310252680.1) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of laryngopharynx swelling and pain and aphtha of the mouth and tongue, primarily of Radix Angelicae Sinensis 4 ~ 12 parts, Radix Scrophulariae 5 ~ 11 parts, Radix Rehmanniae 7 ~ 15 parts, Flos Lonicerae 4 ~ 10 parts, Herba Taraxaci 13 ~ 18 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4 ~ 11 parts, Pericarpium Citri Reticulatae 2 ~ 6 parts, Polyporus 5 ~ 12 parts, 4 ~ 12 parts, Poria, 12 ~ 17 parts, Gypsum Fibrosum, 3 ~ 7 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 4 ~ 9 parts, Caulis Piperis Kadsurae 11 ~ 18 parts composition.Notification number CN102671039A(application number 201210106665.1) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of aphtha of the mouth and tongue, forming former medicine has: Rhizoma Coptidis 2 ~ 4g, Fructus Gardeniae 6 ~ 9g, Spica Prunellae 4 ~ 6g, Radix Paeoniae Rubra 6 ~ 8g, Radix Codonopsis 8 ~ 12g, the Rhizoma Atractylodis Macrocephalae 6 ~ 8g, Cortex Magnoliae Officinalis 6 ~ 8g, Semen Coicis 8 ~ 10g, Radix Scrophulariae 6 ~ 8g, Radix Ophiopogonis 4 ~ 6g, Fructus Corni 6 ~ 8g, Fructus Mume 6 ~ 8g, Cortex Moutan 4 ~ 6g, Rhizoma Corydalis 4 ~ 6g, Folium Bambusae 6 ~ 8g.
Nowadays, have the medicine of a lot for the treatment of aphtha of the mouth and tongue, but these medicines only have certain mitigation, mostly can only take stopgap measures, and can not be completely cured, the time of healing is longer, meeting recurrent exerbation, and has certain side effect.This disease of Chinese traditional treatment, treats according to different disease type is dialectical, has obtained good therapeutic effect, has the Chinese medicine formula of development prospect still in constantly excavating.
Summary of the invention
For overcoming the deficiencies in the prior art, the object of this invention is to provide a kind of good effect, the Chinese medicine composition for the treatment of aphtha of the mouth and tongue of anti-recurrence and method for making thereof.
Technical scheme of the present invention is:
The Chinese medicine composition for the treatment of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs, is weight portion: Flos Chrysanthemi 10-15, Radix Platycodonis 12-20, Borneolum Syntheticum 3-6, beard seven 9-12, Fructus Chebulae 10-15, Rhizoma Cimicifugae 9-12, Radix Puerariae 10-20, Rhizoma Corydalis 6-9, Herba Scutellariae Barbatae 6-9, Cortex Moutan 8-12, little contribution 5-10, Herba Artemisiae Anomalae 8-16.
In preferred scheme, Flos Chrysanthemi 11-14, Radix Platycodonis 14-18, Borneolum Syntheticum 4-5, beard seven 10-11, Fructus Chebulae 11-14, Rhizoma Cimicifugae 10-11, Radix Puerariae 14-16, Rhizoma Corydalis 7-8, Herba Scutellariae Barbatae 7-8, Cortex Moutan 9-11, little contribution 6-9, Herba Artemisiae Anomalae 10-14.
Be more preferably, Flos Chrysanthemi 12.5, Radix Platycodonis 16, Borneolum Syntheticum 4.5, beard 7 10.5, Fructus Chebulae 12.5, Rhizoma Cimicifugae 10.5, Radix Puerariae 15, Rhizoma Corydalis 7.5, Herba Scutellariae Barbatae 7.5, Cortex Moutan 10, little contribution 7.5, Herba Artemisiae Anomalae 12.
Present invention also offers and the Chinese medicine composition of aforementioned therapies aphtha of the mouth and tongue is made pharmaceutically acceptable decoction, the preparation method of described decoction is:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, marmite is placed in, add water retting 1-3 hour (preferred, to flood 2 hours), then big fire is boiled, add the obtained medical material of step (1), turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute, be more preferably, turn little fire and decoct 40 minutes), close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts, collecting by filtration filtrate, merge twice filtrate, be evaporated to 200ml, sterilizing subpackage, obtain Chinese medicine composition decoction.
Described Chinese medicine composition decoction, step (3) the dipping water yield is the 5-9 of medical material weight doubly (preferred, the dipping water yield is 6-8 times of medical material weight, is more preferably, and the dipping water yield is 7 times of medical material weight).
Present invention also offers and the Chinese medicine composition of aforementioned therapies aphtha of the mouth and tongue is made pharmaceutically acceptable powder, the preparation method of described powder is:
(1) by Radix Platycodonis, Fructus Chebulae, Rhizoma Cimicifugae, Rhizoma Corydalis, Herba Scutellariae Barbatae, Cortex Moutan and Herba Artemisiae Anomalae decontamination, 200-260 mesh sieve (preferred, to pulverize 220 order-240 mesh sieves, and be more preferably, pulverized 240 mesh sieves) was pulverized;
(2) Flos Chrysanthemi, beard seven, Radix Puerariae are placed in marmite together with little contribution, add water (preferred with steeping in wine stain 1-3 hour, flood 2 hours), then big fire is boiled, and turns little fire and decocts 30-50 minute (preferably, 35-45 minute decocted by little fire, be more preferably, little fire decocts 40 minutes), close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(3) step (2) remaining filtering residue is watered and wine, again decocts, collecting by filtration filtrate, merge twice filtrate, filter vacuum be dry, pulverize, cross 200 mesh sieves;
(4) by step (1) and the mixing of (3) gained powder, sterilizing, subpackage, obtains Chinese medicine composition composition powders.
Described Chinese medicine composition composition powders, step (2) add water and the amount of wine be the 6-9 of medical material weight doubly, (preferred, add water and the amount of wine be the 7-8 of medical material weight doubly, be more preferably, add water and the amount of wine is 7.5 times of medical material weight), Qi Zhongshui: wine=3:1(weight ratio).
Present invention also offers and the Chinese medicine composition of aforementioned therapies aphtha of the mouth and tongue is made pharmaceutically acceptable pill, the preparation method of described pill is:
(1) by Radix Platycodonis, Fructus Chebulae, Rhizoma Cimicifugae, Rhizoma Corydalis, Herba Scutellariae Barbatae, Cortex Moutan and Herba Artemisiae Anomalae decontamination, 200-260 mesh sieve (preferred, to pulverize 220 order-240 mesh sieves, and be more preferably, pulverized 240 mesh sieves) was pulverized;
(2) Flos Chrysanthemi, beard seven, Radix Puerariae are placed in marmite together with little contribution, steeping in wine stain 1-3 hour that adds the water of medical material weight 6 times and medical material weight 2 times (preferred, flood 2 hours), then big fire is boiled, and turns little fire and decocts 30-50 minute (preferably, 35-45 minute decocted by little fire, be more preferably, little fire decocts 40 minutes), close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(3) step (2) remaining filtering residue is watered and wine, again decocts, collecting by filtration filtrate, merge twice filtrate, filter vacuum be dry, pulverize, cross 200 mesh sieves;
(4) by step (1) and the mixing of (3) gained powder, Mel is added, molding, molding, capping, obtained pill.
Described Chinese medicine composition pill, the ratio of step (4) medicated powder and Mel is (8-10): (2-4) (preferred, the ratio of medicated powder and Mel is 9:3).
Present invention also offers and the Chinese medicine composition of aforementioned therapies aphtha of the mouth and tongue is made pharmaceutically acceptable capsule, the preparation method of described capsule is:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, be placed in marmite, add water retting 1-3 hour (preferably, the dipping 1.5-2.5 hour not having medical material 2cm, be more preferably, flood 2 hours), then big fire is boiled, add the obtained medical material of step (1), turn little fire to decoct 30-50 minute (preferred, 35-45 minute decocted by little fire, is more preferably, little fire decocts 40 minutes), close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts, collecting by filtration filtrate, merge twice filtrate, be evaporated to clear paste, then add sugared mix homogeneously and make soft material, cross 12 mesh sieves and granulate, 60 DEG C of oven dry, granulate, incapsulates every 0.4-0.6g, obtains Chinese medicinal composition capsules.
Described Chinese medicinal composition capsules, the relative density of step (4) clear paste is 1.24-1.30(70 DEG C), (preferred, the relative density of clear paste is 1.26-1.28, is more preferably, and the relative density of clear paste is 1.27).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Flos Chrysanthemi: Flos Chrysanthemi is the dry capitulum of feverfew Flos Chrysanthemi.Nature and flavor with return through: sweet, bitter, be slightly cold.Return lung, Liver Channel.Function with cure mainly: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted, sore and toxic.
Radix Platycodonis: nature and flavor with return through: bitter, pungent, flat.Return lung meridian.Function with cure mainly: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
Borneolum Syntheticum: nature and flavor: arduous, cool.Gui Jing: enter heart channel, lung meridian.Function: logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Cure mainly: control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Beard seven: base is former: be the root and rhizome of ranunculaceae plant Radix Chimonanthi praecocis.Nature and flavor: bitter in the mouth; Cool in nature; Mild toxicity.Cure mainly heat-clearing and toxic substances removing; Promoting blood circulation to remove blood stasis; Reducing swelling and alleviating pain.Main cystitis; Urethritis; Skin ulcer treats toxic swelling; Traumatic injury.
Fructus Chebulae: base is former: the dry mature fruit of Combretum Racemosum plant Fructus Chebulae or Terminalia chebula Retz. var. tomentella Kurt..Nature and flavor with return through: bitter, acid, puckery, flat.Return lung, large intestine channel.Function with cure mainly: relieving diarrhea with astringents, astringing lung-QI and relieving cough, pathogenic fire reducing sore-throat relieving.For chronic diarrhea chronic dysentery, proctoptosis of having blood in stool, the deficiency of the lung is breathed with cough, and chronic cough is more than, pharyngalgia hoarseness.
Rhizoma Cimicifugae: base is former: be the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.Nature and flavor: acrid in the mouth; Sweet; Cold nature.Gui Jing: return lung meridian; Spleen channel; Large intestine channel; Stomach warp.Effect: heat-clearing and toxic substances removing; Deliver rash; Ascending up spleen-Qi and Yang.Cure mainly: diseases caused by exogenous pathogenic factor exterior syndrome, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, macule, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery.
Radix Puerariae: nature and flavor with return through: sweet, pungent, cool.Return spleen, stomach, lung meridian.Function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
Rhizoma Corydalis: base is former: the dry tuber of papaveraceae plant corydalis.Nature and flavor with return through: pungent, bitter, temperature.Return liver, spleen channel.Function with cure mainly: invigorate blood circulation, promoting the circulation of QI to relieve pain.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Herba Scutellariae Barbatae: base is former: be the herb of labiate Herba Scutellariae Barbatae.Nature and flavor: acrid in the mouth; Bitter; Cold in nature.Effect: heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding; Inducing diuresis to remove edema.Cure mainly: pyretic toxicity carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, haematemesis, epistaxis, stranguria with blood, edema, ascites and cancer.
Cortex Moutan: nature and flavor: arduous; Cool; Be slightly cold.Gui Jing: the heart; Liver; Kidney; Lung meridian.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Cure mainly: the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, pathogenic bacteria later stage brimful of tears hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury, beriberoid pyretic arthralgia.
Little contribution: base is former: the Herb of section plant U.S. fruit Psychotria rubra (Lour.) Poir..Nature and flavor: bitter, cool.Function cures mainly: thermal detoxification, wind-expelling pain-stopping.Main bacterium dysentery, enteritis, flu, cough, nephritis, cystitis, rheumatic lumbago and scelalgia, traumatic injury, fracture, venom.
Herba Artemisiae Anomalae: have another name called Herba Artemisiae Anomalae grass, Herba Senecionis Scandentis is the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: stem is cylindrical, surperficial brown color or brown-green, matter is hard and crisp, frangibility, the integrated spike panicle of head inflorescence, withered yellow, gas fragrance, bitter in the mouth, pungent, warm in nature.Composition: mainly containing arteanoflavone, tricin, apigenin, Palmic acid etc.Find according to modern pharmacological research, this medical instrument has effect of anti-hypoxia, blood circulation promoting and blood stasis dispelling, removing food stagnancy, hemostasia and detumescence, for amenorrhea due to stagnation of blood, and abdominal pain due to retention of food, hematuria, the diseases such as scald.
The Chinese medicine composition scientific formula for the treatment of aphtha of the mouth and tongue provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, invent and follow tcm prescription principle, through clinical application for many years checking, effective percentage reaches 100%;
2, this prescription has heat-clearing and toxic substances removing, YIN nourishing dispels fire, reducing swelling and alleviating pain effect.
3, instant effect of the present invention, stable curative effect, anti-recurrence.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 treats the Chinese medicine composition of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs: Flos Chrysanthemi 10g, Radix Platycodonis 12g, Borneolum Syntheticum 3g, beard seven 9g, Fructus Chebulae 10g, Rhizoma Cimicifugae 9g, Radix Puerariae 10g, Rhizoma Corydalis 6g, Herba Scutellariae Barbatae 6g, Cortex Moutan 8g, little contribution 5g, Herba Artemisiae Anomalae 8g.
The preparation method of the Chinese medicine composition decoction of above-mentioned treatment aphtha of the mouth and tongue is:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, marmite is placed in, add the water retting 2 hours of medical material weight 7 times, then big fire is boiled, add the obtained medical material of step (1), turn little fire and decoct 40 minutes, close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts, collecting by filtration filtrate, merge twice filtrate, be evaporated to 200ml, sterilizing subpackage, obtain Chinese medicine composition decoction.
The instructions of taking of decoction of the present invention: decoction is 5 days courses for the treatment of, takes every day twice (warm), each 50m1-70m1.
Embodiment 2 treats the Chinese medicine composition of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs: Flos Chrysanthemi 15g, Radix Platycodonis 20g, Borneolum Syntheticum 6g, beard seven 12g, Fructus Chebulae 15g, Rhizoma Cimicifugae 12g, Radix Puerariae 20g, Rhizoma Corydalis 9g, Herba Scutellariae Barbatae 9g, Cortex Moutan 12g, little contribution 10g, Herba Artemisiae Anomalae 16g.
The preparation method of the Chinese medicine composition composition powders for the treatment of aphtha of the mouth and tongue is:
(1) by Radix Platycodonis, Fructus Chebulae, Rhizoma Cimicifugae, Rhizoma Corydalis, Herba Scutellariae Barbatae, Cortex Moutan and Herba Artemisiae Anomalae decontamination, 240 mesh sieves were pulverized;
(2) Flos Chrysanthemi, beard seven, Radix Puerariae are placed in marmite together with little contribution, add water and the wine of medical material weight 7.5 times, water: wine=3:1(weight ratio), flood 2 hours, then big fire is boiled, and turns little fire and decocts 40 minutes, close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(3) step (2) remaining filtering residue is watered and wine, again decocts, collecting by filtration filtrate, merge twice filtrate, filter vacuum be dry, pulverize, cross 200 mesh sieves;
(4) by step (1) and the mixing of (3) gained powder, sterilizing, subpackage, obtains Chinese medicine composition composition powders.
Model case: xxx, female, 6 years old.After it cyclostrophic is cool, recently drink water less, rear beginning perleche, dry and cracked have a week, aphtha of the mouth and tongue, appetite declines, and takes vitamin C, has no improvement after several days, after there is again swelling of parotid gland 2 days, with headache, constipation, bitter taste yellowish urine, cry and scream and do not stop, then seek medical advice.
Formula of the present invention upon somebody's introduction, has the Chinese medicine composition composition powders that the phychology of having a try takes the present embodiment gained treatment aphtha of the mouth and tongue in arms, each one bag of about 4g, every day 2 times, warm boiled water, 5 days courses for the treatment of.After taking one day, mouth sores sense is obviously gone down, and the open sore part starts to reduce, and headache also disappears, and after continuing to take 2 days, the open sore part heals completely, and appetite is recovered, and angular cheilosis also heals substantially, continues to take 2 days, and patient fully recovers, and follows up a case by regular visits to, have no recurrence after 1 year.
Embodiment 3 treats the Chinese medicine composition of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs: Flos Chrysanthemi 11g, Radix Platycodonis 14g, Borneolum Syntheticum 4g, beard seven 10g, Fructus Chebulae 11g, Rhizoma Cimicifugae 10g, Radix Puerariae 14g, Rhizoma Corydalis 7g, Herba Scutellariae Barbatae 7g, Cortex Moutan 9g, little contribution 6g, Herba Artemisiae Anomalae 10g.
The preparation method of the Chinese medicine composition pill for the treatment of aphtha of the mouth and tongue is:
(1) by Radix Platycodonis, Fructus Chebulae, Rhizoma Cimicifugae, Rhizoma Corydalis, Herba Scutellariae Barbatae, Cortex Moutan and Herba Artemisiae Anomalae decontamination, 240 mesh sieves were pulverized;
(2) Flos Chrysanthemi, beard seven, Radix Puerariae are placed in marmite together with little contribution, add the steeping in wine stain 2 hours of the water of medical material weight 6 times and medical material weight 2 times, then big fire is boiled, turn little fire and decoct 40 minutes, close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(3) step (2) remaining filtering residue is watered and wine, again decocts, collecting by filtration filtrate, merge twice filtrate, filter vacuum be dry, pulverize, cross 200 mesh sieves;
(4) by step (1) and the mixing of (3) gained powder, add Mel, the ratio of medicated powder and Mel is 9:3, molding, molding, capping, obtained pill.
Model case: xxx, 50 years old, man.Suffers from aphtha of the mouth and tongue, existing 4 years, recurrent exerbation throughout the year, increase the weight of year by year, every month 2-3 time, diet is greatly affected, and eats acid, salty, peppery food has pain as calcination, also have saliva when speaking to flow out, frequent constipation, once used BINGPENG SAN treatment, but recurred more afterwards, cure the symptoms, not the disease, effect is undesirable.
Introduce through friend and hear this formula, take the Chinese medicine composition tablet of the present embodiment gained treatment aphtha of the mouth and tongue, adopt twice daily, each 4, with warm boiled water, 5 days courses for the treatment of.After taking one day, pain is obviously alleviated, and appetite is improved, and after continuing to take three days, the open sore part heals substantially, and for consolidate curative effect continues to have taken two days, patient's self-induction is fully recovered, and malaise symptoms disappears, and follows up a case by regular visits to, do not recur after 2 years.
Embodiment 4 treats the Chinese medicine composition of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs: Flos Chrysanthemi 14g, Radix Platycodonis 18g, Borneolum Syntheticum 5g, beard seven 11g, Fructus Chebulae 14g, Rhizoma Cimicifugae 11g, Radix Puerariae 16g, Rhizoma Corydalis 8g, Herba Scutellariae Barbatae 8g, Cortex Moutan 11g, little contribution 9g, Herba Artemisiae Anomalae 14g.
The preparation method of the Chinese medicinal composition capsules agent for the treatment of aphtha of the mouth and tongue is:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, marmite is placed in, add the water retting 2 hours not having medical material 2cm, then big fire is boiled, add the obtained medical material of step (1), turn little fire and decoct 40 minutes, close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decoct, collecting by filtration filtrate, merge twice filtrate, be evaporated to clear paste, the relative density of clear paste is 1.27(70 DEG C), then add sugared mix homogeneously and make soft material, cross 12 mesh sieves and granulate, 60 DEG C of oven dry, granulate, incapsulates every 0.4-0.6g, obtains Chinese medicinal composition capsules.
Model case: xxx, female, 28 years old.Suffers from aphtha of the mouth and tongue existing 5 years; every month at least one times; the general state of an illness continues week more than one; use BINGPENG SAN to coordinate and take detoxicating tablet of cow-bezoar; soon still can recur after recovery from illness, bitter with laryngopharynx swelling and pain, tooth distending pain, dispute time serious, low grade fever; more easily recur when changing according to the season, emotion also becomes comparatively irritated.
Learning formula of the present invention by asking about, taking the Chinese medicinal composition capsules agent of the present embodiment gained treatment aphtha of the mouth and tongue, adopting twice daily, each 3, with warm boiled water, 5 days courses for the treatment of.After taking 1 day, pain just makes moderate progress, and the open sore part starts to diminish, and after taking three days, all malaise symptoms all disappear, and continue to take two days later, and recovery from illness, follows up a case by regular visits to after half a year, do not recur.
Embodiment 5 treats the Chinese medicine composition of aphtha of the mouth and tongue, is prepared from primarily of following bulk drugs: Flos Chrysanthemi 12.5g, Radix Platycodonis 16g, Borneolum Syntheticum 4.5g, beard seven 10.5g, Fructus Chebulae 12.5g, Rhizoma Cimicifugae 10.5g, Radix Puerariae 15g, Rhizoma Corydalis 7.5g, Herba Scutellariae Barbatae 7.5g, Cortex Moutan 10g, little contribution 7.5g, Herba Artemisiae Anomalae 12g.
The preparation method of the Chinese medicine composition decoction for the treatment of aphtha of the mouth and tongue is:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, marmite is placed in, add the water retting 2 hours of medical material weight 7 times, then big fire is boiled, add the obtained medical material of step (1), turn little fire and decoct 40 minutes, close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts, collecting by filtration filtrate, merge twice filtrate, be evaporated to 200ml, sterilizing subpackage, obtain Chinese medicine composition decoction.
The clinical practice of Chinese medicine composition water preparation of test example 1 embodiment 5 gained treatment aphtha of the mouth and tongue: in December, 2012 in August ,-2013,588 routine patients are screened in 6 hospitals, wherein women 328 example, male 260 example, oldest 66 years old, minimal ages 12 years old, 34.1 years old mean age, the course of disease 2 months-2 years.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, and take every day twice (warm), each 50m1-70m1(adjusts to some extent depending on concrete condition), 5 days courses for the treatment of, matched group takes other medicine (conventional medication such as Vc, detoxicating tablet of cow-bezoar, Huanglianshangqing Tablet).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: oral mucosa and the obviously difference of normal nothing, and half a year is without recurrence; Effective: pain disappears, and the circular or oval open sore part obviously diminishes; Effective: pain disappears, and the circular or oval open sore part diminishes; Invalid: malaise symptoms is unchanged.Result is as shown in table 1.
Table 1 liang component group situation and patient's therapeutic outcome after the course for the treatment of of taking medicine
As shown in Table 1: the experimental group patient taking embodiment 5 gained decoction, what be cured has 329 examples (84.8%), and the cure rate of matched group is 71%, therapeutic effect is obviously not as matched group.More several conventional medicine of the therapeutic effect of visible embodiment 5 products obtained therefrom to aphtha of the mouth and tongue is good.
Chrysanthemum powder forimproving wind improving eyesight in the present invention, heat-clearing and toxic substances removing, Borneolum Syntheticum reducing swelling and alleviating pain, beard seven heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, Fructus Chebulae's pathogenic fire reducing sore-throat relieving, rash delivered by Rhizoma Cimicifugae, Herba Scutellariae Barbatae inducing diuresis to remove edema, Cortex Moutan clearing away heat and cooling blood, Herba Artemisiae Anomalae hemostasia and detumescence, multiple medical material use together, has heat-clearing and toxic substances removing, YIN nourishing dispels fiery effect, persistent, stable curative effect, ensures radical cure aphtha of the mouth and tongue, prevents its recurrent exerbation.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (3)
1. treat the Chinese medicine composition of aphtha of the mouth and tongue, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Flos Chrysanthemi 10, Radix Platycodonis 12, Borneolum Syntheticum 3, beard 79, Fructus Chebulae 10, Rhizoma Cimicifugae 9, Radix Puerariae 10, Rhizoma Corydalis 6, Herba Scutellariae Barbatae 6, Cortex Moutan 8, little contribution 5, Herba Artemisiae Anomalae 8.
2. treat the preparation method of the Chinese medicine composition decoction of aphtha of the mouth and tongue, it is characterized in that:
(1) being put by Mel in pot tempers to boiling with slow fire, and filtered while hot, obtains refined honey, then refined honey is added boiled water stir and even in pot, then pour Rhizoma Cimicifugae and Radix Puerariae into, constantly stir-fry, honey and medicine are stirred evenly, honeydew sucks in medicine, and frying tack-free to yellow skin is degree, and then taking the dish out of the pot, it is cool to dry in the air;
(2) by beard seven, Fructus Chebulae, Herba Scutellariae Barbatae and Herba Artemisiae Anomalae decontamination, smash to pieces;
(3) together with obtained to Flos Chrysanthemi, Radix Platycodonis, Rhizoma Corydalis, Cortex Moutan, little contribution and step (2) medical material, marmite is placed in, add water retting 1-3 hour (preferred, to flood 2 hours), then big fire is boiled, add the obtained medical material of step (1), turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute, be more preferably, turn little fire and decoct 40 minutes), close fire and add Borneolum Syntheticum in first 20 minutes, filter after closing fire, collect filtrate;
(4) step (3) remaining filtering residue is watered, again decocts, collecting by filtration filtrate, merge twice filtrate, be evaporated to 200ml, sterilizing subpackage, obtain Chinese medicine composition decoction.
3. preparation method as claimed in claim 2, is characterized in that, step (3) the dipping water yield be the 5-9 of medical material weight doubly (preferred, the dipping water yield be the 6-8 of medical material weight doubly, be more preferably, the dipping water yield is 7 times of medical material weight).
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| CN201610016263.0A Pending CN105456422A (en) | 2014-11-12 | 2014-11-12 | Medicine for treating mouth and tongue sores |
| CN201610016264.5A Pending CN105456423A (en) | 2014-11-12 | 2014-11-12 | Pills for treating mouth and tongue sores |
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| CN201610016262.6A Pending CN105535175A (en) | 2014-11-12 | 2014-11-12 | Method for preparing traditional Chinese medicine composition decoction for treating oral ulcer |
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| CN101491614A (en) * | 2008-11-27 | 2009-07-29 | 北京宏泰康达医药科技有限公司 | Traditional Chinese medicine composition for treating mouth and tongue sore and stomatocace |
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| CN100388922C (en) * | 2004-02-24 | 2008-05-21 | 贵州益佰制药股份有限公司 | Chinese medicinal preparation for treating sorethroat, aphtha and its preparation method |
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| CN102671039A (en) * | 2012-04-04 | 2012-09-19 | 张敏丽 | Chinese medicinal composition for treating aphtha of mouth and tongue |
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| CN105535176A (en) | 2016-05-04 |
| CN105535175A (en) | 2016-05-04 |
| CN104306491B (en) | 2016-05-25 |
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