CN105395871A - Oral liquid resisting chemotherapy side reaction - Google Patents

Oral liquid resisting chemotherapy side reaction Download PDF

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CN105395871A
CN105395871A CN201510904350.5A CN201510904350A CN105395871A CN 105395871 A CN105395871 A CN 105395871A CN 201510904350 A CN201510904350 A CN 201510904350A CN 105395871 A CN105395871 A CN 105395871A
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parts
radix
hour
rhizoma
spleen
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不公告发明人
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/537—Salvia (sage)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K9/08—Solutions
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention discloses an oral liquid resisting chemotherapy side reaction. The oral liquid is prepared from the following main raw materials by weight: 5-9 parts of white paeony root, 6-12 parts of Salvia Miltiorrhiza, 3-9 parts of bletilla striata, 6-15 parts of poria cocos, 8-15 parts of Eupatorium fortunei, 20-35 parts of Kudzuvine Root, 4-12 parts of Coptis chinensis, 6-15 parts of Herba Artemisiae Anomalae, 4-9 parts of bighead atractylodes rhizome, 3-9 parts of Cuscuta Chinensis, 3-7 parts of atractylodes lancea, 2-8 parts of psoralea corylifolia (salt processed), 2-6 parts of Clematis chinensis, and 3-8 parts of pine pollen. The materials selected by the invention are all traditional Chinese medicinal materials, have no toxic or side effect. The oral liquid has very good therapeutic effect on the side effects caused by chemotherapy, and has the efficacy of strengthening spleen and harmonizing stomach.

Description

The oral liquid of anti-chemotherapy side effect
divisional application, original applying number 2014101448674, applying date 2014.04.12, the invigorating the spleen and regulating the stomach preparation of the anti-chemotherapy side effect of title and method for making.
Technical field
The invention discloses a kind of invigorating the spleen and regulating the stomach preparation, the invigorating the spleen and regulating the stomach preparation of especially anti-chemotherapy side effect and method for making.The invention belongs to traditional Chinese medicine field.
Background technology
Chemotherapy carrys out disease therapy by chemical substance, is one of Main Means for the treatment of tumor and some autoimmune disease at present.It is utilize chemicals kill tumor cell, inhibition tumor cell growth and breeding and promote a kind of therapeutic modality of differentiation of tumor cell, it is that a kind of systemic treatment means all have therapeutical effect to primary tumor, metastasis and subclinical metastasis, but chemotherapeutic treatment tumor is while killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so be the Therapeutic Method of a kind of " destruction of all people good and bad alike ".
Neoplastic conditions is main mainly with chemotherapeutic treatment in early days, and the course of disease is lasted longer mostly, and prolonged illness easily consumes impairment of QI the moon, therefore the disease of the common deficiency of both QI and YIN of tumor patient, easily occurs the symptoms such as dry mouth and throat, health be weak; And chemotherapy mostly is chemistry poison, each radiotherapy all directs at taste, following side effect can be caused to taste: weakness of the spleen and stomach, abnormal ascending-descending of QI and occur play abdominal distention and pain, nausea and vomiting, health is tired, the symptoms such as lassitude, in addition, also normal with the general reaction relevant with chemotherapy, immunologic function degression etc.Weakness of the spleen and stomach the foundation of acquired constitution is impaired, then insufficiency of vital energy and blood, more causes deficiency of qi and yin.So move in circles, the state of an illness more not easily takes a turn for the better.The digestive tract reaction caused after chemotherapy of tumors belongs to the category such as the traditional Chinese medical science " stomach painful abdominal mass ", " vomiting ", and, mainly at the five internal organs, there are much relations its sick position with taste: taste are become estranged, weakness of the spleen and stomach, deficiency of both QI and YIN are main pathologic basis.
Chemotherapy has certain therapeutic effect to tumor, can the slight illness of reduction of patient to a certain extent, improve the curative effect of tumor, but the toxic and side effects of chemotherapy produces very large inhibitory action to taste, so develop the medicine of anti-chemotherapy side effect, make tumor patient can better acceptance treatment tool be of great significance.Chinese medicine, in this reaction of improvement, has obvious advantage, but what be really developed to new drug is not a lot, and the medication effect developed is also not obvious.Invigorating the spleen and regulating the stomach preparation of the present invention is consulting on the basis of a large amount of documents and materials and clinical trial, become estranged for the weakness of the spleen and stomach caused by chemotherapy, taste and the main hypertensive TCM pathogenesis of deficiency of both QI and YIN, while significantly improving the toxicity that chemotherapy causes taste, the immunologic function of patient, hemopoietic function of bone marrow etc. can also be improved, thus reach and improve patient, strengthen the object of patient body quality, make patient better accept treatment, to improve the cure rate of patient.
Application publication number is CN102327390A(application number 201110314905.2) Chinese patent literature disclose a kind of by name " a kind of prevent and treat the Chinese prescription of chemotherapy toxic side effect and the preparation method of pill thereof ", this Chinese prescription is made up of according to certain weight proportion Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, Moschus, Stalactitum, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Radix Glycyrrhizae, Colla cornus cervi, yellow wine.Its formula medical material is numerous, and indivedual price of medicinal material is higher, adds the financial burden of patient.Application publication number is CN103623338A(application number 201310275217.9) Chinese patent literature disclose a kind of by name " Chinese medicine granules of Therapeutic cancer chemotherapy metenteron side effect and preparation method thereof ", this Chinese medicine granules by Radix Astragali 600-800g, Radix Ophiopogonis 250-350g, Radix Ginseng Rubra 150-250g, Rhizoma Atractylodis Macrocephalae (parched with bran) 150-250g, Poria 150-250g, Radix Glycyrrhizae 200-300g, Radix Scrophulariae 200-300g, Radix Angelicae Sinensis 200-300g, Fructus Mume 250-350g, Rhizoma Pinelliae Preparatum 250-350g, Herba Pogostemonis 200-300g, Pericarpium Citri Reticulatae 200-300g, Rhizoma Curcumae 200-300g form.This Chinese medicine granules preparation method is complicated, is not suitable for individual's operation.
Summary of the invention
For the slightly not enough present situation of existing anti-chemotherapy side effect, an object of the present invention is the invigorating the spleen and regulating the stomach preparation providing a kind of anti-chemotherapy side effect, there is the features such as easy to operate, evident in efficacy, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost and without any side effects.
Another object of the present invention is just to provide the preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation.
Technical scheme of the present invention is:
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from: Radix Paeoniae Alba 5-9 part, Radix Salviae Miltiorrhizae 6-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 part, Poria 6-15 part, Herba Eupatorii 8-15 part, Radix Puerariae 20-35 part, Rhizoma Coptidis 4-12 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Rhizoma Atractylodis 3-7 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Paeoniae Alba 6-8 part, Radix Salviae Miltiorrhizae 8-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part, Poria 8-11 part, Herba Eupatorii 10-13 part, Radix Puerariae 25-30 part, Rhizoma Coptidis 6-10 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Semen Cuscutae 5-7 part, Rhizoma Atractylodis 4-6 part, Fructus Psoraleae (salt is processed) 4-6 part, Radix Clematidis 3-5 part, Pollen Pini 5-7 part.
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
Present invention also offers and above-mentioned invigorating the spleen and regulating the stomach preparation is made pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed 65-125 mesh sieve and (preferably, cross 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) being pulverized adds step (3) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably, 0.8 part), add the Pollen Pini after step (1) pulverizing, mixing, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably, 6 parts) and appropriate amount of ethanol, make granule, dry.
The preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferably, 0.5-0.7g/ sheet; Be more preferably, 0.6g/ sheet) metering, the tablet dosage form of circle or other shapes is pressed into according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.6-1.0g/ grain (preferably, 0.7-0.9g/ grain; Be more preferably, 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Paeoniae Alba: nature and flavor: bitter in the mouth, acid, is slightly cold.Gui Jing: return liver, spleen channel.Effect: joint venture of nourishing blood, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly: blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, and has a headache dizzy.
Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, is slightly cold.Gui Jing: GUIXIN, pericardium, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, removing heat from blood eliminating carbuncle.Cure mainly: menoxenia, dysmenorrhea, amenorrhea, stomachache of being retarded by silt puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, and heat enters nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter in the mouth, sweet, puckery, is slightly cold.Gui Jing: return lung, kidney channel.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Cure mainly: spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Poria: nature and flavor: sweet in the mouth, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Eupatorii: nature and flavor: acrid in the mouth, flat.Gui Jing: return spleen, stomach warp.Effect: expelling summer-heat and damp, be amusing and in.Cure mainly: heat-damp in summer or hygropyrexia from the beginning of, generate heat nose heave, abdominal distention uncomfortable in chest, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, quenches one's thirst.
Radix Puerariae: nature and flavor: sweet in the mouth, pungent is flat.Gui Jing: return spleen, stomach warp.Effect: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly: typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
Rhizoma Coptidis: nature and flavor: bitter in the mouth, cold.Gui Jing: GUIXIN, liver, stomach, large intestine channel.Effect: clearing away heat-fire, dampness, removing toxic substances.Cure mainly: calentura heresy enters the high heat of heart channel, irritated, delirium or the absurd row of intenseness of heat forcing blood tell nosebleed, damp and hot Bears painful abdominal mass is had loose bowels, dysentery, the vexed insomnia of hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue, Ting ear, hemorrhoidal bleeding, eczema, scalds.
Herba Artemisiae Anomalae: nature and flavor: bitter in the mouth, temperature.Gui Jing: GUIXIN, lung meridian.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Cure mainly: amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter in the mouth, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.
Semen Cuscutae: nature and flavor: micro-pungent, sweet is flat.Gui Jing: return liver, kidney channel.Effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Cure mainly: the waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Rhizoma Atractylodis: nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return spleen, stomach, Liver Channel.Effect: drying damp and strengthening spleen, wind-damp dispelling, improving eyesight.Cure mainly: the spleen and stomach being stranded by dampness, asthenia drowsiness, feeling of stuffiness in chest abdominal distention, inappetence, vomiting is had loose bowels, phlegm retention, damp-edema, and exterior syndrome folder is wet, and head heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere is ached and weighed ， flaccidity of feet with lamenness, nyctalopia.
Fructus Psoraleae (salt is processed): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return kidney, spleen channel.Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly: main insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, outward for vitiligo, and alopecia areata, psoriasis.
Radix Clematidis: nature and flavor: pungent, salty, temperature.Gui Jing: return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly: gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Pollen Pini: nature and flavor: sweet in the mouth, temperature.Gui Jing: return liver, spleen channel.Effect: QI invigorating of dispeling the wind, removing dampness, hemostasis.Cure mainly: head revolves dizzy, middle void has a stomach-ache, chronic dysentery, and all skin ulcers wet rotten, wound hemorrhage.
Invigorating the spleen and regulating the stomach preparation of the present invention makes on the basis that have studied amount of literature data and clinical trial, and have effect of invigorating the spleen and regulating the stomach, the side reaction caused for chemotherapy has good therapeutic effect.And the medical material selected is Chinese medicine material, determined curative effect and without any side effects.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation powder is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: powder is divided 8g/ bag, adopts every day 2-3 time, each one bag, with warm boiled water, and 7 days courses for the treatment of.
model case oneyellow XX, age: 80 years old, sex: female.Patient finds that abdominal swelling thing Progressive symmetric erythrokeratodermia increases in August, 2006, bilateral in May, 2007 thoracic cavity and seroperitoneum, and ascites finds adenocarcinoma cell, primary tumor is not quite clear, in June, 2007, emergency hospitalization required to put ascites immediately because of huge Abdominal mass companion severe ascites, after treated by chemotherapy.The chemotherapy malaise symptoms such as cause weakness of the spleen and stomach, nausea and vomiting, dry mouth and tougue, health tired.Take the present embodiment gained invigorating the spleen and regulating the stomach preparation powder, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patient's dry mouth and tougue symptom alleviates, and malaise symptoms is alleviated to some extent; Take 2 months, patient's malaise symptoms fades away, and spirit, muscle power strengthen; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 2the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation unguentum is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) being pulverized adds step (3) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 6-10g, takes according to the ratio bath of 1:10,7 days courses for the treatment of.
model case twoold XX, age: 48 years old, sex: man.Patient's abdominal circumference 103cm, abdominal part has touched multiple thing as swollen greatly in fist, and rectal sinuses touches transfer lump as large in egg.One's belly is tight as a drum, become thin, weak, tachypnea, general pain ascites find adenocarcinoma cell.Regularly accept chemotherapy to treat, but chemotherapy causes that taste are uncomfortable, health is weak, inappetence with phenomenons such as nausea and vomiting, take the medicine of anti-chemotherapy side effect, without positive effect, present patient becomes thin extremely.Take the present embodiment gained invigorating the spleen and regulating the stomach preparation unguentum, adopt every day 2 times, each 10g, take according to the ratio bath of 1:10,7 days courses for the treatment of.Take 14 days, patient's malaise symptoms alleviates, and food of receiving is gradually many; Take 1 month, patients ' vomiting alleviates, and muscle power strengthens, and malaise symptoms fades away; Continue to take 2 months, patient's self-induction is fully recovered.
embodiment 3the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (every part of 30g): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation granules agent is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.8 part, add the Pollen Pini after step (1) pulverizing, mixing, with sucrose 6 parts and appropriate amount of ethanol, makes granule, dry.
Granule instructions of taking of the present invention: granule is divided 10g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threewu XX, age: 45 years old, sex: female.Patient carries out right side defeated flexible pipe papillary adenocarcinoma excision in August, 2006, and carcinoma invades uterus, rectum, carries out a cycle chemotherapy and creates serious side reaction: weakness of the spleen and stomach, appetite are low, drowsiness, nausea and vomiting, lassitude etc.Take the agent of the present embodiment gained invigorating the spleen and regulating the stomach preparation granules, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of.Take 1 month, patient's appetite strengthens, and malaise symptoms improves gradually; Take 2 months, patient's muscle power strengthens, and the mental status is clearly better, and malaise symptoms fades away; Continue to take 2 months, malaise symptoms disappears.
embodiment 4the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (every part of 40g): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach formulation tablet is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.6g/ sheet, be pressed into the tablet dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets instructions of taking: tablet adopts every day 3 times, each 5-8 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourlee XX, age: 68 years old, sex: man.In February, 2008 stomach discomfort, certainly touching epigastrium has the swollen greatly thing of egg, and gastroscopy pathology confirms malignant lymphoma, and additional regular chemotherapy accepts treatment, and chemotherapy causes following side reaction :the malaise symptoms such as dry mouth and tougue, taste discomfort, lassitude, health are tired.Take the present embodiment gained invigorating the spleen and regulating the stomach formulation tablet, secondary to every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 10 days, dry mouth and tougue alleviates, and malaise symptoms is alleviated; Take 1 month, patient's appetite strengthens, and the mental status is improved, and malaise symptoms fades away; Continue to take 2 months, patient's malaise symptoms disappears completely.
embodiment 5the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (every part of 50g): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation capsule is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.8g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 4-6 grain, with warm boiled water, 7 days courses for the treatment of.
model case fiveking XX, age: 53 years old, sex: man.Within 2007, suffer from Esophageal Middle Segment malignant tumor, accept chemotherapy in hospital, occur the symptoms such as acroanesthesia, nausea and vomiting, inappetence, health be tired after chemotherapy, ate the medicine of many anti-chemotherapy side effects, all without positive effect.Take this enforcement gained invigorating the spleen and regulating the stomach preparation capsule, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 15 days, patient's appetite strengthens to some extent, and nausea and vomiting alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power strengthens; Continue to take 2 months, patient's readme malaise symptoms disappears.
embodiment 6the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material stating weight proportion and is prepared from (every part of 60g): the Radix Paeoniae Alba 7 parts, Radix Salviae Miltiorrhizae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, 10 parts, Poria, Herba Eupatorii 11 parts, Radix Puerariae 28 parts, Rhizoma Coptidis 8 parts, Herba Artemisiae Anomalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Semen Cuscutae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Psoraleae (salt is processed) 5 parts, Radix Clematidis 4 parts, Pollen Pini 6 parts.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation water preparation is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
test example 1the clinical practice of embodiment 6 gained invigorating the spleen and regulating the stomach preparation water preparation: in March ,-2012 in October, 2008, screen 200 routine patients in 8 hospitals, wherein women 106 example, male 94 example.Before test 3 weeks, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 6 products obtained therefrom, and matched group takes other medicine (conventional medication such as safe peace oral liquid, holy liquid oral liquid, selenium Wei Kang).Using method is: daily twice (warm), and each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take the checking of embodiment 6 products obtained therefrom therapeutic effect
Therapeutic effect: cure 71 examples (71%), effective 28 examples (28%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
As shown in Table 2: take 10 days, the patients ' vomiting of more than 54% alleviates, malaise symptoms takes a turn for the better to some extent; Take 20 days, the patient of more than 73% feels to take a turn for the better to some extent, and weakness of the spleen and stomach symptom is improved, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 95% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients self-induction is fully recovered.Take more than 30 days in experimental group, effective percentage can reach 95%, and matched group is only 75%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (2)

1. the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: the Radix Paeoniae Alba 9 parts, Radix Salviae Miltiorrhizae 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, 15 parts, Poria, Herba Eupatorii 15 parts, Radix Puerariae 35 parts, Rhizoma Coptidis 12 parts, Herba Artemisiae Anomalae 15 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Semen Cuscutae 9 parts, Rhizoma Atractylodis 7 parts, Fructus Psoraleae (salt is processed) 8 parts, Radix Clematidis 6 parts, Pollen Pini 8 parts.
2. the preparation method of the invigorating the spleen and regulating the stomach preparation water preparation of anti-chemotherapy side effect, is characterized in that,
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
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CN201510904009.XA Withdrawn CN105434862A (en) 2014-04-12 2014-04-12 Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy
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