CN104436053A - Traditional Chinese medicine composition for treating gastric body cancer - Google Patents
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gastric body cancer. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 2-3 parts of water chestnut hull, 2-3 parts of impatiens balsamina, 5-15 parts of glaucescent fissistigma root, 5-15 parts of poria cocos, 10-20 parts of raw astragalus membranaceus, 3-5 parts of fiveleaf akebia fruit, 3-8 parts of sculellaria barbata, 2-3 parts of curcuma zedoary, 3-5 parts of rhizoma corydalis, 3-5 parts of alpinia katsumadai, 2-3 parts of fruit of princesplume ladysthumb, 2-3 parts of felwort, 2-3 parts of fructus forsythiae, 2-3 parts of elecampane, 2-3 parts of radix cynanchi bungei and 3-5 parts of licorice root. The traditional Chinese medicine composition is prepared into decoction. Due to use of medicinal raw materials having the effects of nourishing yin to generate body fluid, supporting the healthy energy, reducing swelling and resolving mass, the traditional Chinese medicine composition can be used for inhibiting reproduction of tumors, controlling tumor spread and tumor metastasis, enhancing the immunity, relieving paint, removing tumors, relieving the pain of a patient and saving the life of the patient.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly a kind of Chinese medicine composition for the treatment of body of stomach cancer.
Background technology
Gastric cancer ranks first in the various malignant tumor of China, betides body of stomach district mucosa person, is called body of stomach cancer.The most patient's non-evident sympton of early stage body of stomach cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with sb.'s illness took a turn for the worse progress for Upper abdominal pain increase the weight of, appetite decline, weak.Late period body of stomach carninomatosis people often can there is anemia, become thin, the malnutrition even symptom such as cachexia.
For the treatment of gastric cancer, current I, II phase gastric cancer, based on surgical radical treatment excision, postoperative II phase gastric cancer can be considered to carry out chemotherapy and treatment by Chinese herbs; III phase gastric cancer is striven for making radical excision, if really can not make radical correction, makes palliative resection; IV phase gastric cancer and without obvious metastasis person, wherein some cases can make radical surgery or palliative resection, can not the person of excision do short circuit operation, postoperative employing chemotherapeutic treatment.But the equal defectiveness of method of operation and chemotherapeutic treatment, operative treatment is the means of topical therapeutic, like water off a duck's back for the tumor cell transferred in blood or its hetero-organization; Chemotherapy effectively can hinder cancerous cell, but can kill and wound normal cell and cause the immunologic function of patient suppressed again simultaneously, occurs more complication, brings very big damage to patient body.Chinese patent (CN102861193A) discloses a kind of Chinese medicine for the treatment of gastric cancer, there is the effect of dispersing swelling and dissipating binds, detoxicating and fighting cancer, but only for Vitro Tumor experiment and mouse experiment effective, the therapeutic effect of actual patient is remained to be discussed, treatment cycle does not explain yet, and actual popularization has certain restriction.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of body of stomach cancer, by the effect of the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds, Tumor suppression is bred, control tumor diffusion transfer, enhancing immunity, and can pain relieving dispersing tumor, alleviate patient's misery, save patients ' lives.
The invention provides a kind of Chinese medicine composition for the treatment of body of stomach cancer, formulated by the raw material of Chinese medicine of following parts by weight: Shell of Water Chestnut 2 ~ 3 parts, Semen Impatientis 2 ~ 3 parts, Radix Fissistigmatis Glaucescentis 5 ~ 15 parts, 5 ~ 15 parts, Poria, Radix Astragali 10 ~ 20 parts, Fructus Akebiae 3 ~ 5 parts, Herba Scutellariae Barbatae 3 ~ 8 parts, Rhizoma Curcumae 2 ~ 3 parts, Rhizoma Corydalis 3 ~ 5 parts, Semen Alpiniae Katsumadai 3 ~ 5 parts, Fructus Polygoni Orientalis 2 ~ 3 parts, Radix Gentianae 2 ~ 3 parts, Fructus Forsythiae 2 ~ 3 parts, the Radix Aucklandiae 2 ~ 3 parts, Radix Cynanchi Auriculati 2 ~ 3 parts, 3 ~ 5 parts, Radix Glycyrrhizae.
More preferably formulated by the raw material of Chinese medicine of following parts by weight: Shell of Water Chestnut 3 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 10 parts, 10 parts, Poria, Radix Astragali 15 parts, Fructus Akebiae 4 parts, Herba Scutellariae Barbatae 5 parts, Rhizoma Curcumae 2 parts, Rhizoma Corydalis 4 parts, Semen Alpiniae Katsumadai 4 parts, Fructus Polygoni Orientalis 2 parts, Radix Gentianae 3 parts, Fructus Forsythiae 2 parts, the Radix Aucklandiae 2 parts, Radix Cynanchi Auriculati 3 parts, 4 parts, Radix Glycyrrhizae.
Preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 2 ~ 5cm, soaks 1 ~ 2 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20 ~ 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Pharmacology analysis:
Shell of Water Chestnut: sweet in the mouth, puckery, cool in nature; The spleen invigorating of effect invigorating the spleen and replenishing QI, strong stock knee joint, strong power QI invigorating, cure mainly have loose bowels, proctoptosis, hemorrhoid, treatment are swollen, impetigo, pemphigus.Modern pharmacology proves, Shell of Water Chestnut has the effects such as anti-treatment of esophagus cancer, gastric cancer, cervical cancer, breast carcinoma, can be used as cancer therapy drug.
Semen Impatientis: micro-hardship, pungent, temperature, slightly poisonous; Return spleen, Liver Channel.Function relieves internal heat the detumescence of anticancer, scattered silt.Removing blood stasis softening the hard mass, removing food stagnancy.Yong Yu WEIJIA mass in the abdomen, amenorrhea, dysphagic.Drug sensitive test proves that it is to gastric lymphosarcoma sensitizing cells; Inhibitory action is had to sarcoma-37.
Radix Fissistigmatis Glaucescentis: taste is micro-pungent, puckery, warm in nature; Return Liver Channel.Effect wind-damp dispelling, restores menstrual flow and invigorates blood circulation, hemostasis; For rheumatic arthralgia, menoxenia, traumatic injury, fracture, traumatic hemorrhage.Modern study proves, Radix Fissistigmatis Glaucescentis also has antitumor action, can play antitumor action by improving immunologic function.Radix Fissistigmatis Glaucescentis toxicity is very little.
Poria: sweet in the mouth, light, property is put down, and enters the heart, spleen, lung, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming.Cure mainly lack of appetite gastral cavity painful abdominal mass, vomiting is had loose bowels, palpitation and restlessness, insomnia forgetfulness, edema distension, dysuria, seminal emission turbid urine etc.Modern pharmacological research is reported, Poria has immunostimulant, antitumor, diuresis, calmness, lifting leukocyte, heart tonifying, defying age, protection gastrointestinal, protect the liver and the effect such as resisting pathogenic microbes.
Radix Astragali: sweet in the mouth, slightly warm in nature, returns spleen, lung meridian, enters edema caused by disorder of QI, can rise and can fall.Effect tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, detoxification granulation promoting.Cure mainly internal injury overstrain, spiritlessness and weakness, diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, visceroptosis, failure of the spleen to keep the blood flowing within the vessels hemorrhage, spontaneous perspiration, night sweat etc.Ancient books " herbal warp " is stated: " complement sun, fills space between skin and muscles, control impairment caused by overstrain, longue meat." " book on Chinese herbal medicine converge with speech " say: " tonifying the lung spleen invigorating, defends arresting sweating in fact, fortune of dispeling the wind poison." " in inner feelings ginseng west record medicine " state: " kind diuresis ", " kindly control disabled wilted limbs." modern pharmacological research report, the Radix Astragali be significantly improved immunologic function, protection cardiac muscle, protect and improve hemopoietic system, antioxidation, defying age, antitumor, diuresis protect kidney, regulate the effects such as blood glucose, nervous system regulation, antibacterial, antiviral and facilitating digestion function.
Fructus Akebiae: bitter in the mouth, property is put down; Return liver, stomach warp; Function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.Modern pharmacological research is reported, it has inhibitory action to tumor cell.
Herba Scutellariae Barbatae: pungent, flat.There is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.
Rhizoma Curcumae: pungent, bitter, temperature; Return liver, spleen channel.Cure mainly coagulation of QI-blood, trusted subordinate's distending pain, lump in the abdomen, gathers, and dyspepsia does not disappear, and women's blood stasis amenorrhea, traumatic injury is had a pain.
Rhizoma Corydalis: warm in nature, acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Li Shizhen (1518-1593 A.D.) concludes Rhizoma Corydalis in Compendium of Material Medica " invigorate blood circulation, regulate the flow of vital energy, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".
Semen Alpiniae Katsumadai: pungent, temperature; Return lung meridian, spleen channel, stomach warp.Function removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving; Cure mainly for turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Fructus Polygoni Orientalis: salty in the mouth, is slightly cold, nontoxic; Enter liver, stomach, spleen three warp.Function heat clearing away, softening the hard mass.Repercussive removing mass, invigorating spleen to remove dampness.Control flank disease amassing, dropsy, has a stomach-ache, lack of appetite abdominal distention, acute catarrhal conjunctivitis, and skin ulcer swells, scrofula.
Radix Gentianae: bitter in the mouth, cold in nature.Return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear swells; Hypochondriac pain bitter taste; Calentura convulsion with spasms.
Fructus Forsythiae: bitter, is slightly cold; Return lung, the heart, gallbladder meridian.Effect heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, eliminating carbuncle eliminating stagnation, QI and blood of not only faling apart cohesion again can eliminating carbuncle eliminating stagnation, for clearing away heart-fire, loose part of the body cavity above the diaphragm housing the heart and lungs wind heat.
The Radix Aucklandiae: acrid in the mouth is bitter, warm in nature; Return spleen, large intestine, tri-jiao channel.Effect circulation of qi promoting, pain relieving, spleen invigorating, helps digestion; Promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune; Cure mainly born of the same parents and coerce distension foot, abdominal distention, tells and has loose bowels, heavy after dysentery, and for weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Sudden deafness; Snake bite and insect sting; Toothache.
Radix Cynanchi Auriculati: bitter but sweet flavor is puckery, slightly warm in nature is nontoxic; Enter liver, kidney two warp.Effect nourishing the liver and kidney, strengthening body, nourishes blood and enriches blood, crow palpus hair color, convergence vital essence, promoting tissue regeneration and ulcer healing, loosening bowel to relieve constipation.Cure mainly prolonged illness weakness, chronic migratory arthralgia, soreness of the waist and knees, anemia, enterorrhagia, early whitening of beard and hair, neurasthenia, deficiency of YIN chronic malaria, ulcer does not close up for a long time, old people constipation.Modern pharmacology proves, the strain of Radix Cynanchi Auriculati general glycoside multiple cancer all has obvious antitumaous effect.
Radix Glycyrrhizae: sweet in the mouth, property is put down; Enter spleen, stomach, lung meridian; Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Chinese medicine of the present invention, by the effect of the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds, Tumor suppression is bred, and controls tumor diffusion transfer, enhancing immunity, and can pain relieving dispersing tumor, alleviates patient's misery, saves patients ' lives.
Outcome measure:
Effective: body constitution strengthens, limbs are strong, and abdominal discomfort disappears, and body of stomach district mucomembranous tumour tumor body reduces, and other position has no nascent tumor,
Effective: body constitution strengthens, and body of stomach district mucomembranous tumour has no increase, and other position has no nascent tumor;
Invalid: symptom is unchanged, body of stomach district mucomembranous tumour tumor body increases, or nascent tumor appears in other position.
Therapeutic outcome: treat 145 body of stomach cancer patients 1 month is a course for the treatment of, 1 day for oral administration 1 dose, take at twice.After using 2 course for the treatment of Chinese medicines of the present invention, effective 75 examples, account for 51.7%, and effective 68 examples, account for 46.9%, and invalid 2 examples, account for 1.4%.
Attached several routine case is described further:
Case 1: cattle so-and-so, man, 60 years old, without obvious inducement stomach pain, feed after symptom a few hours, generally after rising morning, and 5 PM occur.Gastroscope shows: body of stomach: the visible huge ulcer of the little curved rear wall in upper end, and the end is deeply recessed, and surface is covered with filthy tongue, surrounding mucosa congestion and edema, biopsy 5 pieces, and matter is hard, biopsy elasticity loss; Gastric antrum: be dispersed in erosion as seen, wriggles normal.After a few days, gastroscopy display body of stomach tumor be irregular glandular tube shape again, and lamellar arranges, and cell is special-shaped obvious, the large engrain of core, and sees that tumor is inclined profit interstitial.Pathological diagnosis is body of stomach adenocarcinoma.Then give Chinese medicine of the present invention to treat, effective after 2 courses for the treatment of, tumor disappearance after half a year, follows up a case by regular visits to half a year without recurrence.
Case 2: Yang, man, 63 years old, pathological diagnosis is body of stomach adenocarcinoma, and gastric body mucosa color and luster is pale, the huge ulcer in large curved side, periphery tuberosity neoplasm, reflux esophagitis, stomach angle mucosa color and luster is pale, pylorus hole ovalize, shrink poor, then give medicine of the present invention, effective after using 2 courses for the treatment of, effective after 3 courses for the treatment of, follow up a case by regular visits to 1 year tumor without increase phenomenon.
Detailed description of the invention
Embodiment 1:
Treat a Chinese medicine composition for body of stomach cancer, formulated by the raw material of Chinese medicine of following parts by weight: Shell of Water Chestnut 3 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 10 parts, 10 parts, Poria, Radix Astragali 15 parts, Fructus Akebiae 4 parts, Herba Scutellariae Barbatae 5 parts, Rhizoma Curcumae 2 parts, Rhizoma Corydalis 4 parts, Semen Alpiniae Katsumadai 4 parts, Fructus Polygoni Orientalis 2 parts, Radix Gentianae 3 parts, Fructus Forsythiae 2 parts, the Radix Aucklandiae 2 parts, Radix Cynanchi Auriculati 3 parts, 4 parts, Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 3cm, soaks 1.5 hours; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 30min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Embodiment 2:
Treat a Chinese medicine composition for body of stomach cancer, formulated by the raw material of Chinese medicine of following parts by weight: Shell of Water Chestnut 2 parts, Semen Impatientis 3 parts, Radix Fissistigmatis Glaucescentis 5 parts, 15 parts, Poria, Radix Astragali 10 parts, Fructus Akebiae 5 parts, Herba Scutellariae Barbatae 3 parts, Rhizoma Curcumae 3 parts, Rhizoma Corydalis 3 parts, Semen Alpiniae Katsumadai 5 parts, Fructus Polygoni Orientalis 2 parts, Radix Gentianae 3 parts, Fructus Forsythiae 2 parts, the Radix Aucklandiae 3 parts, Radix Cynanchi Auriculati 2 parts, 5 parts, Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 5cm, soaks 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Embodiment 3:
Treat a Chinese medicine composition for body of stomach cancer, formulated by the raw material of Chinese medicine of following parts by weight: Shell of Water Chestnut 3 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 15 parts, 5 parts, Poria, Radix Astragali 20 parts, Fructus Akebiae 3 parts, Herba Scutellariae Barbatae 8 parts, Rhizoma Curcumae 2 parts, Rhizoma Corydalis 5 parts, Semen Alpiniae Katsumadai 3 parts, Fructus Polygoni Orientalis 3 parts, Radix Gentianae 2 parts, Fructus Forsythiae 3 parts, the Radix Aucklandiae 2 parts, Radix Cynanchi Auriculati 3 parts, 3 parts, Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 2cm, soaks 2 hours; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.
Claims (2)
1. treat a Chinese medicine composition for body of stomach cancer, it is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Shell of Water Chestnut 2 ~ 3 parts, Semen Impatientis 2 ~ 3 parts, Radix Fissistigmatis Glaucescentis 5 ~ 15 parts, 5 ~ 15 parts, Poria, Radix Astragali 10 ~ 20 parts, Fructus Akebiae 3 ~ 5 parts, Herba Scutellariae Barbatae 3 ~ 8 parts, Rhizoma Curcumae 2 ~ 3 parts, Rhizoma Corydalis 3 ~ 5 parts, Semen Alpiniae Katsumadai 3 ~ 5 parts, Fructus Polygoni Orientalis 2 ~ 3 parts, Radix Gentianae 2 ~ 3 parts, Fructus Forsythiae 2 ~ 3 parts, the Radix Aucklandiae 2 ~ 3 parts, Radix Cynanchi Auriculati 2 ~ 3 parts, 3 ~ 5 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for the treatment of body of stomach cancer as claimed in claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Shell of Water Chestnut 3 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 10 parts, 10 parts, Poria, Radix Astragali 15 parts, Fructus Akebiae 4 parts, Herba Scutellariae Barbatae 5 parts, Rhizoma Curcumae 2 parts, Rhizoma Corydalis 4 parts, Semen Alpiniae Katsumadai 4 parts, Fructus Polygoni Orientalis 2 parts, Radix Gentianae 3 parts, Fructus Forsythiae 2 parts, the Radix Aucklandiae 2 parts, Radix Cynanchi Auriculati 3 parts, 4 parts, Radix Glycyrrhizae.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804171A (en) * | 2010-05-13 | 2010-08-18 | 白如冰 | Medicine for treating gastric cancer |
| CN102861193A (en) * | 2012-10-28 | 2013-01-09 | 杨献华 | Traditional Chinese medicine composition for treating gastric cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804171A (en) * | 2010-05-13 | 2010-08-18 | 白如冰 | Medicine for treating gastric cancer |
| CN102861193A (en) * | 2012-10-28 | 2013-01-09 | 杨献华 | Traditional Chinese medicine composition for treating gastric cancer |
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