CN104771570A - Compound medicine for treating gastric cancer - Google Patents
Compound medicine for treating gastric cancer Download PDFInfo
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- CN104771570A CN104771570A CN201510106071.4A CN201510106071A CN104771570A CN 104771570 A CN104771570 A CN 104771570A CN 201510106071 A CN201510106071 A CN 201510106071A CN 104771570 A CN104771570 A CN 104771570A
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Abstract
The invention discloses a compound medicine for treating gastric cancer. The medicine is prepared from the following raw materials by weight: 3-5 parts of Ranunculus ternatus, 4-6 parts of Fructus Polygoni orientalis, 3-5 parts of myrrh, 3-5 parts of Rabdosia rubescens, 3-5 parts of indigo, 5-8 parts of radix sophorae tonkinensis, 2-4 parts of Platycodon grandiflorum, 2-4 parts of cortex moutan, 6-10 parts of Astragalus mongholicus, 6-8 parts of Radix Pseudostellariae, 1-3 parts of Ganoderma lucidum, 5-8 parts of donkey hide gelatin, 8-10 parts of cortex albizziae, 2-5 parts of selfheal, 2-4 parts of Scutellaria, 2-4 parts of golden cypress, 2-4 parts of Forsythia suspensa Vahl, 2-4 parts of dandelion, 2-5 parts of pseudobulubs cremastrae seu pleiones, 3-5 parts of Herba patriniae, 2-3 parts of allii macrostemi bulbus, 5-8 parts of setose thistle, 3-5 parts of seaweed and 3-5 parts of kelp. According to the theories of supporting right, securing the root, and promoting blood circulation to remove blood stasis in traditional Chinese medicine, the compound medicine realizes the effects of tonifying the liver and kidney, supplementing qi, nourishing Yin, heat clearing, detoxifying and dismissing swelling, and has the advantages of simultaneous treatment of principal and subordinate symptoms, good curative effect and quick effectiveness.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly a kind of compound medicine for the treatment of body of stomach cancer.
Background technology
Gastric cancer ranks first in the various malignant tumor of China, betides body of stomach district mucosa person, is called body of stomach cancer.The most patient's non-evident sympton of early stage body of stomach cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with sb.'s illness took a turn for the worse progress for Upper abdominal pain increase the weight of, appetite decline, weak.Late period body of stomach carninomatosis people often can there is anemia, become thin, the malnutrition even symptom such as cachexia.
In China, body of stomach cancer morbidity and mortality rate are all in second, greatly threaten the life and health of the mankind.2012, national tumor population Standardized incidence rate was 146.87/10 ten thousand people, and wherein the gastric cancer of digestive system accounts for 12.67%, and intestinal cancer accounts for 10.30%, and hepatocarcinoma accounts for 10.04%, and the esophageal carcinoma accounts for 7.74%, the very severe state of its prevention and control situation.In China, for each patient, the expense of antitumor drug is all a white elephant.Except the chemotherapeutics of routine, humanized antibody drug, molecular targeted agents, novel targeted carrier medicament are all very expensive.And Chinese medicine is with a long history, determined curative effect, simultaneously cheap, be suitable for promoting.Therefore how to excavate the precious deposits of Chinese medicine at anti-tumor aspect, benefiting patient better, is the realistic problem that each work of Chinese medicine person faces.
For the treatment of gastric cancer, current I, II phase gastric cancer, based on surgical radical treatment excision, postoperative II phase gastric cancer can be considered to carry out chemotherapy and treatment by Chinese herbs; III phase gastric cancer is striven for making radical excision, if really can not make radical correction, makes palliative resection; IV phase gastric cancer and without obvious metastasis person, wherein some cases can make radical surgery or palliative resection, can not the person of excision do short circuit operation, postoperative employing chemotherapeutic treatment.But the equal defectiveness of method of operation and chemotherapeutic treatment, operative treatment is the means of topical therapeutic, like water off a duck's back for the tumor cell transferred in blood or its hetero-organization; Chemotherapy effectively can hinder cancerous cell, but can kill and wound normal cell and cause the immunologic function of patient suppressed again simultaneously, occurs more complication, brings very big damage to patient body.
Summary of the invention
The invention provides a kind of compound medicine for the treatment of body of stomach cancer, by the effect of the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds, Tumor suppression is bred, control tumor diffusion transfer, enhancing immunity, and can pain relieving dispersing tumor, alleviate patient's misery, save patients ' lives.
The compound medicine for the treatment of body of stomach cancer of the present invention, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Shell of Water Chestnut 2-3 part, Semen Impatientis 2-3 part, Radix Fissistigmatis Glaucescentis 5-15 part, Poria 5-15 part, Radix Astragali 10-20 part, Fructus Akebiae 3-5 part, Herba Scutellariae Barbatae 3-8 part, Fructus Forsythiae 2-3 part, Radix Cynanchi Auriculati 2-3 part, Rhizoma Paridis 5-10 part, Radix Actinidiae Chinensis 3-5 part, Fructus Camptothecae Acuminatae 2-3 part, Rhizoma Smilacis Chinensis 2-3 part, Herba Taraxaci 3-5 part, Radix Scrophulariae 2-4 part and Radix Ophiopogonis 2-4 part.
As preferably, prepare by following parts by weight: Shell of Water Chestnut 2 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 10 parts, 10 parts, Poria, Radix Astragali 15 parts, Fructus Akebiae 4 parts, Herba Scutellariae Barbatae 6 parts, Fructus Forsythiae 2 parts, Radix Cynanchi Auriculati 2 parts, Rhizoma Paridis 8 parts, Radix Actinidiae Chinensis 4 parts, Fructus Camptothecae Acuminatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Taraxaci 4 parts, Radix Scrophulariae 3 parts and Radix Ophiopogonis 3 parts.
Preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 2-5cm, soaks 1-2 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20-40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Each decoction being taken warmly 200-300ml, every day early, evening twice is bfore meals, within one month, is a course for the treatment of.
Pharmacology analysis:
Shell of Water Chestnut: sweet in the mouth, puckery, cool in nature; The spleen invigorating of effect invigorating the spleen and replenishing QI, strong stock knee joint, strong power QI invigorating, cure mainly have loose bowels, proctoptosis, hemorrhoid, treatment are swollen, impetigo, pemphigus.Modern pharmacology proves, Shell of Water Chestnut has the effects such as anti-treatment of esophagus cancer, gastric cancer, cervical cancer, breast carcinoma, can be used as cancer therapy drug.
Semen Impatientis: micro-hardship, pungent, temperature, slightly poisonous; Return spleen, Liver Channel.Function relieves internal heat the detumescence of anticancer, scattered silt.Removing blood stasis softening the hard mass, removing food stagnancy.Yong Yu WEIJIA mass in the abdomen, amenorrhea, dysphagic.Drug sensitive test proves that it is to gastric lymphosarcoma sensitizing cells; Inhibitory action is had to sarcoma-37.
Radix Fissistigmatis Glaucescentis: taste is micro-pungent, puckery, warm in nature; Return Liver Channel.Effect wind-damp dispelling, restores menstrual flow and invigorates blood circulation, hemostasis; For rheumatic arthralgia, menoxenia, traumatic injury, fracture, traumatic hemorrhage.Modern study proves, Radix Fissistigmatis Glaucescentis also has antitumor action, can play antitumor action by improving immunologic function.Radix Fissistigmatis Glaucescentis toxicity is very little.
Poria: sweet in the mouth, light, property is put down, and enters the heart, spleen, lung, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming.Cure mainly lack of appetite gastral cavity painful abdominal mass, vomiting is had loose bowels, palpitation and restlessness, insomnia forgetfulness, edema distension, dysuria, seminal emission turbid urine etc.Modern pharmacological research is reported, Poria has immunostimulant, antitumor, diuresis, calmness, lifting leukocyte, heart tonifying, defying age, protection gastrointestinal, protect the liver and the effect such as resisting pathogenic microbes.
Radix Astragali: sweet in the mouth, slightly warm in nature, returns spleen, lung meridian, enters edema caused by disorder of QI, can rise and can fall.Effect tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, detoxification granulation promoting.Cure mainly internal injury overstrain, spiritlessness and weakness, diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, visceroptosis, failure of the spleen to keep the blood flowing within the vessels hemorrhage, spontaneous perspiration, night sweat etc.Ancient books " herbal warp " is stated: " complement sun, fills space between skin and muscles, control impairment caused by overstrain, longue meat." " book on Chinese herbal medicine converge with speech " say: " tonifying the lung spleen invigorating, defends arresting sweating in fact, fortune of dispeling the wind poison." " in inner feelings ginseng west record medicine " state: " kind diuresis ", " kindly control disabled wilted limbs." modern pharmacological research report, the Radix Astragali be significantly improved immunologic function, protection cardiac muscle, protect and improve hemopoietic system, antioxidation, defying age, antitumor, diuresis protect kidney, regulate the effects such as blood glucose, nervous system regulation, antibacterial, antiviral and facilitating digestion function.
Fructus Akebiae: bitter in the mouth, property is put down; Return liver, stomach warp; Function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.Modern pharmacological research is reported, it has inhibitory action to tumor cell.
Herba Scutellariae Barbatae: pungent, flat.There is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.
Fructus Forsythiae: bitter, is slightly cold; Return lung, the heart, gallbladder meridian.Effect heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, eliminating carbuncle eliminating stagnation, QI and blood of not only faling apart cohesion again can eliminating carbuncle eliminating stagnation, for clearing away heart-fire, loose part of the body cavity above the diaphragm housing the heart and lungs wind heat.
Radix Cynanchi Auriculati: bitter but sweet flavor is puckery, slightly warm in nature is nontoxic; Enter liver, kidney two warp.Effect nourishing the liver and kidney, strengthening body, nourishes blood and enriches blood, crow palpus hair color, convergence vital essence, promoting tissue regeneration and ulcer healing, loosening bowel to relieve constipation.Cure mainly prolonged illness weakness, chronic migratory arthralgia, soreness of the waist and knees, anemia, enterorrhagia, early whitening of beard and hair, neurasthenia, deficiency of YIN chronic malaria, ulcer does not close up for a long time, old people constipation.Modern pharmacology proves, the strain of Radix Cynanchi Auriculati general glycoside multiple cancer all has obvious antitumaous effect.
Rhizoma Paridis: hardship is slightly cold mild toxicity, enters Liver Channel.Function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion; Cure mainly digestive tract carcinoma, pulmonary carcinoma, the cerebral tumor and malignant lymphoma, the clinical stagnant malignant lymphoma of pyretic toxicity harmony, pulmonary carcinoma, nasopharyngeal carcinoma, the cerebral tumor and the digestive system tumor of being used for is as gastric cancer, the esophageal carcinoma, hepatocarcinoma etc.
Radix Actinidiae Chinensis: function heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, preventing tumor is anticancer, expelling wind and removing dampness, diuresis is stopped blooding, and removing toxic substances and promoting subsidence of swelling, cures mainly the diseases such as dyspepsia, vomiting, rheumatic arthralgia, rheumatic ostalgia, Alimentary Tract Cancer, digestive tract tumor, carbuncle and ulcer furuncle, rheumatic ostalgia and jaundice.
Fructus Camptothecae Acuminatae: cold in nature is bitter in the mouth, puckery, poisonous.Function is anticancer, eliminating stagnation, removing blood stasis, for kinds of tumors, as gastric cancer, intestinal cancer, chorionic epithelioma, lymphosarcoma etc.
Rhizoma Smilacis Chinensis: expelling wind and removing dampness, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, stranguria with turbid discharge, leukorrhagia, has loose bowels, dysentery, carbuncle sore tumefacting virus, stubborn dermatitis, burn and scald; Removing toxic substances, wind dispelling, skin ulcer section key medicine, has diaphoresis, wind dispelling, diuresis and control gonorrhea, cancer, the function of diabetes. wherein with gastric cancer and esophageal carcinoma effect better; Leaf is mashed lemma and is controlled malignant boil.
Herba Taraxaci: sweet in the mouth, micro-hardship, cold in nature, return liver, stomach, kidney channel.Function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dehumidifying diuresis.Cure mainly the carbuncle pyogenic infections from tumour or sore that all pyretic toxicity are caused, mumps, scrofula; The pharyngalgia that pathogenic heat is caused, conjunctival congestion, gastralgia, dysentery, jaundice, frequent micturition dysurea, cancer of the esophagus cancerous protuberance, worm venom etc.
Radix Scrophulariae: salty in the mouth is cold in nature; Effect removing heat from blood YIN nourishing, eliminating fire and detoxication, fever excessive thirst, spontaneous sweating, constipation, haematemesis nose bleeding, pharyngolaryngitis, pulmonary tuberculosis; Constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus is hindered for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, Tianjin.
Radix Ophiopogonis: the micro-sugariness of property is bitter, cold; Sweet micro-bitter cold; Enter lung stomach heart channel; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; For dryness of the lung dry cough, vexed insomnia, interior-heat is quenched one's thirst.
Compound medicine of the present invention, Semen Impatientis hard masses softening and resolving, detumescence; Shell of Water Chestnut, Poria, Radix Astragali, Radix Cynanchi Auriculati liver and kidney tonifying, Yin-nourishing and body fluid promoting; The heat-clearing and toxic substances removing such as Herba Scutellariae Barbatae, Fructus Forsythiae, Rhizoma Paridis, Radix Actinidiae Chinensis, Herba Taraxaci, dispersing swelling and dissipating binds; Select Radix Fissistigmatis Glaucescentis, Fructus Akebiae, Fructus Camptothecae Acuminatae, Rhizoma Smilacis Chinensis four taste antitumor drug; All medicine compatibilities, liver and kidney tonifying, supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, dismiss detumescence, treatment body of stomach cancer, treating both the principal and secondary aspects of a disease, good effect, instant effect.
Outcome measure:
The main clinic symptoms of body of stomach cancer has: performance weight not wait stomachache, gastrorrhagia, abdominal mass and lose weight; The symptom of malignant tumor is more, heavier, and carcinoid symptom is lighter or at all asymptomatic; CT shows tumor body.
Effective: body constitution strengthens, limbs are strong, and abdominal discomfort disappears, and tumor tumor body reduces, and other position has no nascent tumor.
Take a turn for the better: tumor body reduces, and sign and symptom are improved.
Invalid: sign and tumorous size such as front or tumor body increase.
Therapeutic outcome: body of stomach cancer patient 100 example, takes medicine of the present invention, takes raw material of Chinese medicine, add cold water by above-mentioned weight portion, do not have medical material 2-5cm, soaks 1-2 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20-40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps decoct, after cooked, the medicine juice of twice decoction is merged, each decoction being taken warmly 200-300ml, every day morning, late twice ante cibum decoction being taken warmly.Effective 63 examples, account for 63%, and take a turn for the better 20 examples, and account for 20%, effective percentage is 83%.
Attached several routine case is described further:
Case 1: relative, man, 40 years old, in July, 2013 examined, and readme burst stomach pain, generally after rising morning, and 5 PM occurs.Gastroscope shows: body of stomach: the visible huge ulcer of the little curved rear wall in upper end, and the end is deeply recessed, and surface is covered with filthy tongue, surrounding mucosa congestion and edema, biopsy 5 pieces, and matter is hard, biopsy elasticity loss; After a few days, gastroscopy display body of stomach tumor be irregular glandular tube shape again, and lamellar arranges, and cell is special-shaped obvious, the large engrain of core, and sees that tumor is inclined profit interstitial.Pathological diagnosis is body of stomach adenocarcinoma.Give Chinese medicine of the present invention to treat, effective after 2 courses for the treatment of, tumor disappearance after half a year, follows up a case by regular visits to half a year without recurrence.
Case 2: Jiang, man, 39 years old, in May, 2013 examines, readme burst Nausea and vomiting, stomachache, and pathological diagnosis is body of stomach adenocarcinoma, gastric body mucosa color and luster is pale, the huge ulcer in large curved side, periphery tuberosity neoplasm, reflux esophagitis, stomach angle mucosa color and luster is pale, pylorus hole ovalize, shrink poor, give medicine of the present invention, after using 2 courses for the treatment of, above-mentioned malaise symptoms is alleviated, effective after 3 courses for the treatment of, follow up a case by regular visits to half a year tumor without increase phenomenon.
Detailed description of the invention
Embodiment 1
Shell of Water Chestnut 2-3 part, Semen Impatientis 2-3 part, Radix Fissistigmatis Glaucescentis 5-15 part, Poria 5-15 part, Radix Astragali 10-20 part, Fructus Akebiae 3-5 part, Herba Scutellariae Barbatae 3-8 part, Fructus Forsythiae 2-3 part, Radix Cynanchi Auriculati 2-3 part, Rhizoma Paridis 5-10 part, Radix Actinidiae Chinensis 3-5 part, Fructus Camptothecae Acuminatae 2-3 part, Rhizoma Smilacis Chinensis 2-3 part, Herba Taraxaci 3-5 part, Radix Scrophulariae 2-4 part and Radix Ophiopogonis 2-4 part.
Preparation method is made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 5cm, soaks 1.5 hours; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Each decoction being taken warmly 250ml, every day early, evening twice is bfore meals, within one month, is a course for the treatment of.
Claims (2)
1. treat a compound medicine for body of stomach cancer, it is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Shell of Water Chestnut 2-3 part, Semen Impatientis 2-3 part, Radix Fissistigmatis Glaucescentis 5-15 part, Poria 5-15 part, Radix Astragali 10-20 part, Fructus Akebiae 3-5 part, Herba Scutellariae Barbatae 3-8 part, Fructus Forsythiae 2-3 part, Radix Cynanchi Auriculati 2-3 part, Rhizoma Paridis 5-10 part, Radix Actinidiae Chinensis 3-5 part, Fructus Camptothecae Acuminatae 2-3 part, Rhizoma Smilacis Chinensis 2-3 part, Herba Taraxaci 3-5 part, Radix Scrophulariae 2-4 part and Radix Ophiopogonis 2-4 part.
2. the compound medicine for the treatment of body of stomach cancer according to claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Shell of Water Chestnut 2 parts, Semen Impatientis 2 parts, Radix Fissistigmatis Glaucescentis 10 parts, 10 parts, Poria, Radix Astragali 15 parts, Fructus Akebiae 4 parts, Herba Scutellariae Barbatae 6 parts, Fructus Forsythiae 2 parts, Radix Cynanchi Auriculati 2 parts, Rhizoma Paridis 8 parts, Radix Actinidiae Chinensis 4 parts, Fructus Camptothecae Acuminatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Taraxaci 4 parts, Radix Scrophulariae 3 parts and Radix Ophiopogonis 3 parts.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104958537A (en) * | 2015-07-31 | 2015-10-07 | 山东省立医院 | Traditional Chinese medicinal composition for treating stomach cancer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352924A (en) * | 2014-09-30 | 2015-02-18 | 赵文飞 | Traditional Chinese medicine formula for treating stomach cancer and preparation method of traditional Chinese medicine formula |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104352924A (en) * | 2014-09-30 | 2015-02-18 | 赵文飞 | Traditional Chinese medicine formula for treating stomach cancer and preparation method of traditional Chinese medicine formula |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958537A (en) * | 2015-07-31 | 2015-10-07 | 山东省立医院 | Traditional Chinese medicinal composition for treating stomach cancer and preparation method thereof |
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Application publication date: 20150715 |