CN104383519A - Chinese and western medicine composition curing stomach cancer and preparation method for Chinese and western medicine composition - Google Patents
Chinese and western medicine composition curing stomach cancer and preparation method for Chinese and western medicine composition Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to a Chinese and western medicine composition curing stomach cancer and a preparation method for the Chinese and western medicine composition. The traditional Chinese medicine components of the Chinese and western medicine composition are the following raw materials in parts by weight: 2-3 parts of garden balsam, 5-10 parts of paris polyphylla, 3-5 parts of camptotheca acuminata fruit, 3-5 parts of radix actinidiae chinensis, 2-3 parts of barbed skullcap herb, 2-3 parts of smilax, 5-10 parts of water caltrop shell, 10-20 parts of raw hoantchy root, 3-5 parts of galangal, and 3-5 parts of liquorice; the western medicine components of the Chinese and western medicine composition are the following raw materials in parts by weight: 5-10 parts of xeloda, 4-6 parts of Alpha-mannatide, and 4-6 parts of trametes versicolor glycopeptide. The Chinese and western medicine composition is prepared into capsules; efficiencies of nourishing Yin, promoting the secretion of saliva or body fluid, supporting healthy energy, reducing swelling and dissipating stagnation of the traditional Chinese medicine components are combined with the targeted function of the western medicine components, so that the Chinese and western medicine composition can directly act on tumor tissue, and can be more direct in tumor killing function and higher in safety.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, particularly a kind of Chinese and western medicinal composition for the treatment of gastric cancer and preparation method thereof.
Background technology
Gastric cancer ranks first in the various malignant tumor of China.The most patient's non-evident sympton of early gastric cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with sb.'s illness took a turn for the worse progress for Upper abdominal pain increase the weight of, appetite decline, weak.Often can there is anemia, become thin in late gastric cancer patient, the malnutrition even symptom such as cachexia.
For the treatment of gastric cancer, current I, II phase gastric cancer, based on surgical radical treatment excision, postoperative II phase gastric cancer can be considered to carry out chemotherapy and treatment by Chinese herbs; III phase gastric cancer is striven for making radical excision, if really can not make radical correction, makes palliative resection; IV phase gastric cancer and without obvious metastasis person, wherein some cases can make radical surgery or palliative resection, can not the person of excision do short circuit operation, postoperative employing chemotherapeutic treatment.But the equal defectiveness of method of operation and chemotherapeutic treatment, operative treatment is the means of topical therapeutic, like water off a duck's back for the tumor cell transferred in blood or its hetero-organization; Chemotherapy effectively can hinder cancerous cell, but can kill and wound normal cell and cause the immunologic function of patient suppressed again simultaneously, occurs more complication, brings very big damage to patient body.Chinese patent (CN102861193A) discloses a kind of Chinese medicine for the treatment of gastric cancer, there is the effect of dispersing swelling and dissipating binds, detoxicating and fighting cancer, but the therapeutic effect of simple Chinese medicine is unstable, and this patent is only tested for Vitro Tumor and mouse experiment is effective, the therapeutic effect of actual patient is remained to be discussed, treatment cycle does not explain yet, and actual popularization has certain restriction.
Summary of the invention
The object of this invention is to provide a kind of Chinese and western medicinal composition for the treatment of gastric cancer and preparation method thereof, there is easy to use, the short treating period of preparation and feature evident in efficacy; By the targeting of the effect combined with westem of the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds, can tumor tissues be directly acted on, make medicine have more direct tumor-killing effect and better safety.
The invention provides a kind of Chinese and western medicinal composition for the treatment of gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 ~ 3 parts, Rhizoma Paridis 5 ~ 10 parts, Fructus Camptothecae Acuminatae 3 ~ 5 parts, Radix Actinidiae Chinensis 3 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 3 parts, Rhizoma Smilacis Chinensis 2 ~ 3 parts, Shell of Water Chestnut 5 ~ 10 parts, Radix Astragali 10 ~ 20 parts, Rhizoma Alpiniae Officinarum 3 ~ 5 parts, 3 ~ 5 parts, Radix Glycyrrhizae; Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5 ~ 10 parts, α-mannatide 4 ~ 6 parts, polysaccharide-peptide 4 ~ 6 parts.
Wherein Chinese medicinal components is more preferably formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts, Radix Glycyrrhizae.
Wherein western medicine component is more preferably formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
Preparation method is made up of following steps: 1, take raw material of Chinese medicine by above-mentioned parts by weight, cleans, for subsequent use after dry, ultraviolet-sterilization; 2, take Western medicine raw material by above-mentioned parts by weight, wear into fine powder for subsequent use; 3, the raw material of Chinese medicine weighed up is added 5 ~ 10 times amount soak by water 1 ~ 3 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spraying dry, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing; 4, add the Western medicine raw material taken, mixing, incapsulates with every 0.3 ~ 0.6g dosage, packs.
Pharmacology analysis:
Semen Impatientis: micro-hardship, pungent, temperature, slightly poisonous; Return spleen, Liver Channel.Function relieves internal heat the detumescence of anticancer, scattered silt.Removing blood stasis softening the hard mass, removing food stagnancy.Yong Yu WEIJIA mass in the abdomen, amenorrhea, dysphagic.Drug sensitive test proves that it is to gastric lymphosarcoma sensitizing cells; Inhibitory action is had to sarcoma-37.
Rhizoma Paridis: hardship is slightly cold mild toxicity, enters Liver Channel.Function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion; Cure mainly digestive tract carcinoma, pulmonary carcinoma, the cerebral tumor and malignant lymphoma, the clinical stagnant malignant lymphoma of pyretic toxicity harmony, pulmonary carcinoma, nasopharyngeal carcinoma, the cerebral tumor and the digestive system tumor of being used for is as gastric cancer, the esophageal carcinoma, hepatocarcinoma etc.
Fructus Camptothecae Acuminatae: cold in nature is bitter in the mouth, puckery, poisonous.Function is anticancer, eliminating stagnation, removing blood stasis, for kinds of tumors, as gastric cancer, intestinal cancer, chorionic epithelioma, lymphosarcoma etc.
Radix Actinidiae Chinensis: function heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, preventing tumor is anticancer, expelling wind and removing dampness, diuresis is stopped blooding, and removing toxic substances and promoting subsidence of swelling, cures mainly the diseases such as dyspepsia, vomiting, rheumatic arthralgia, rheumatic ostalgia, Alimentary Tract Cancer, digestive tract tumor, carbuncle and ulcer furuncle, rheumatic ostalgia and jaundice.
Herba Scutellariae Barbatae: pungent, flat; Function heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer; Cure mainly appendicitis, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, gastric cancer, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.
Rhizoma Smilacis Chinensis: expelling wind and removing dampness, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, stranguria with turbid discharge, leukorrhagia, has loose bowels, dysentery, carbuncle sore tumefacting virus, stubborn dermatitis, burn and scald; Removing toxic substances, wind dispelling, skin ulcer section key medicine, has diaphoresis, wind dispelling, diuresis and control gonorrhea, cancer, the function of diabetes. wherein with gastric cancer and esophageal carcinoma effect better; Leaf is mashed lemma and is controlled malignant boil.
Shell of Water Chestnut: sweet in the mouth, puckery, cool in nature; The spleen invigorating of effect invigorating the spleen and replenishing QI, strong stock knee joint, strong power QI invigorating, cure mainly have loose bowels, proctoptosis, hemorrhoid, treatment are swollen, impetigo, pemphigus.Modern pharmacology proves, Shell of Water Chestnut has the effects such as anti-treatment of esophagus cancer, gastric cancer, cervical cancer, breast carcinoma, can be used as cancer therapy drug.
Radix Astragali: sweet in the mouth, slightly warm in nature, returns spleen, lung meridian, enters edema caused by disorder of QI, can rise and can fall.Effect tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, detoxification granulation promoting.Cure mainly internal injury overstrain, spiritlessness and weakness, diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, visceroptosis, failure of the spleen to keep the blood flowing within the vessels hemorrhage, spontaneous perspiration, night sweat etc.Ancient books " herbal warp " is stated: " complement sun, fills space between skin and muscles, control impairment caused by overstrain, longue meat." " book on Chinese herbal medicine converge with speech " say: " tonifying the lung spleen invigorating, defends arresting sweating in fact, fortune of dispeling the wind poison." " in inner feelings ginseng west record medicine " state: " kind diuresis ", " kindly control disabled wilted limbs." modern pharmacological research report, the Radix Astragali be significantly improved immunologic function, protection cardiac muscle, protect and improve hemopoietic system, antioxidation, defying age, antitumor, diuresis protect kidney, regulate the effects such as blood glucose, nervous system regulation, antibacterial, antiviral and facilitating digestion function.
Rhizoma Alpiniae Officinarum: pungent, the large temperature of nature and flavor, nontoxic.Return spleen, stomach warp, function warming stomach for dispelling cold, help digestion pain relieving, cures mainly coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Radix Glycyrrhizae: sweet in the mouth, property is put down; Enter spleen, stomach, lung meridian; Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Capecitabine: be a kind of antimetabolic 5-FU deoxynucleoside carbamates medicine that can be transformed into 5-FU in vivo, be mainly used in advanced primary or metastatic breast cancer, the treatment of rectal cancer, colon cancer and gastric cancer.
α-mannatide: the medicine being enhancing immunity, for the auxiliary treatment of immunologic hypofunction, recurrent respiratory tract infection, leukopenia and aplastic anemia and tumor, alleviates the side effect of Radiotherapy chemotherapy to hemopoietic system.
Polysaccharide-peptide: the macromolecule glycopeptide polymer extracted in the mycelium of bacterial strain Cov-1, nourishing the essence and strengthening QI, invigorating spleen and nourishing heart.Certain protective effect is had to cellular immune function and hemogram.For the deficiency of both QI and YIN caused by the esophageal carcinoma, gastric cancer and Patients With Primary Lung Cancer Radiotherapy chemotherapy, deficiency of both the heart and spleen card.
In the present invention, Semen Impatientis, Rhizoma Paridis, Fructus Camptothecae Acuminatae, Radix Actinidiae Chinensis, Herba Scutellariae Barbatae, Rhizoma Smilacis Chinensis, Shell of Water Chestnut all have the effect preventing and treating gastric cancer, and Radix Astragali, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae, there is effect of the pain relieving that helps digestion, enhancing immunity and the adjustment property of medicine, to arrange in pairs or groups the treatment that the property of medicine of medicine of the present invention can be made to be more suitable for gastric cancer with cancer therapy drug; And, the basis of Chinese medicinal components is added capecitabine, α-mannatide and polysaccharide-peptide, the targeting of combined with westem, can tumor tissues be directly acted on, make medicine have more direct tumor-killing effect and better safety.
Take Chinese medicine and western medicine composition of medicine of the present invention, one time 2, every day twice, point sooner or later two inferior to half an hour, use water was swallowed after meal, and being used in conjunction two weeks, having a rest one week, three weeks is a course for the treatment of.As the state of an illness continue worsen or produce not tolerant toxicity time should stop treatment, gestation and women breast-feeding their children be cautious use of.
Outcome measure:
Effective: body constitution strengthens, limbs are strong, and abdominal discomfort disappears, and tumor stomach tumor body reduces, and other position has no nascent tumor;
Effective: body constitution strengthens, and tumor stomach has no increase, and other position has no nascent tumor;
Invalid: symptom is unchanged, tumor stomach tumor body increases, or nascent tumor appears in other position.
Therapeutic outcome: treat 158 patients with gastric cancer, after using 2 course for the treatment of medicines of the present invention, effective 146 examples, account for 92.4%, and effective 11 examples, account for 7.0%, and invalid 1 example, accounts for 0.6%.
Attached several routine case is described further:
Case 1: week certain, man, 69 years old, come institute and check pathological examination display pacing stomach specimen: the long 15CM of greater gastric curvature, little curved 8cm, lesser curvature side was shown in ulcer swollen body thing 4.5*3cm, around mucosa wall protuberance, and the end is coarse, and omentum majus 12.5 × 12 × 1.5cm, is inside shown in enlarged lymph node.Light microscopic finding: cancerous tissue is glandular tube shape, mesh-like growth, and out-of-shape, cell atypia is obvious, and the large engrain of core, visible kernel, organization table meets personally non-viable non-apoptotic cell, and cancerous tissue infiltrative growth is to coat of the stomach holostrome.Pathological diagnosis: break up adenocarcinoma in gastric ulcer type, cancerous tissue invades coat of the stomach holostrome, then gives medicine of the present invention and treats, effective after using 2 courses for the treatment of, effective after 3 courses for the treatment of, follows up a case by regular visits to 1 year tumor without increase phenomenon.
Case 2: Xue so-and-so, female, 70 years old, because occurring that acid regurgitation is heartburn without obvious inducement, after feed obviously, disease Progressive symmetric erythrokeratodermia increased the weight of to come here and seeks medical advice.Gastroscopy lesser curvature side visible 3cm size similar round ulcer, the end, puts down, upper attached dirty tongue, and periphery mucosa owes smooth; Pathology is shown as adenocarcinoma, then gives medicine of the present invention, effective after 2 courses for the treatment of, and tumor disappearance after half a year, follows up a case by regular visits to half a year without recurrence.
Detailed description of the invention
The following stated embodiment, is only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modifies, all should still belong in covering scope of the present invention.
Embodiment 1:
Treat a Chinese and western medicinal composition for gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts, Radix Glycyrrhizae; Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
Preparation method is made up of following steps: 1, take raw material of Chinese medicine by above-mentioned parts by weight, cleans, for subsequent use after dry, ultraviolet-sterilization; 2, take Western medicine raw material by above-mentioned parts by weight, wear into fine powder for subsequent use; 3, the raw material of Chinese medicine weighed up is added 6 times amount soak by water 2 hours, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spraying dry, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing; 4, add the Western medicine raw material taken, mixing, incapsulates with every 0.5g dosage, packs.
Embodiment 2:
Treat a Chinese and western medicinal composition for gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 10 parts, Fructus Camptothecae Acuminatae 3 parts, Radix Actinidiae Chinensis 5 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 3 parts, Shell of Water Chestnut 5 parts, Radix Astragali 20 parts, Rhizoma Alpiniae Officinarum 3 parts, 5 parts, Radix Glycyrrhizae; Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5 parts, α-mannatide 6 parts, polysaccharide-peptide 4 parts.
Preparation method is made up of following steps: 1, take raw material of Chinese medicine by above-mentioned parts by weight, cleans, for subsequent use after dry, ultraviolet-sterilization; 2, take Western medicine raw material by above-mentioned parts by weight, wear into fine powder for subsequent use; 3, the raw material of Chinese medicine weighed up is added 10 times amount soak by water 1 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spraying dry, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing; 4, add the Western medicine raw material taken, mixing, incapsulates with every 0.6g dosage, packs.
Embodiment 3:
Treat a Chinese and western medicinal composition for gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 3 parts, Rhizoma Paridis 5 parts, Fructus Camptothecae Acuminatae 5 parts, Radix Actinidiae Chinensis 3 parts, Herba Scutellariae Barbatae 3 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 10 parts, Radix Astragali 10 parts, Rhizoma Alpiniae Officinarum 5 parts, 3 parts, Radix Glycyrrhizae; Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 10 parts, α-mannatide 4 parts, polysaccharide-peptide 6 parts.
Preparation method is made up of following steps: 1, take raw material of Chinese medicine by above-mentioned parts by weight, cleans, for subsequent use after dry, ultraviolet-sterilization; 2, take Western medicine raw material by above-mentioned parts by weight, wear into fine powder for subsequent use; 3, the raw material of Chinese medicine weighed up is added 5 times amount soak by water 3 hours, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spraying dry, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing; 4, add the Western medicine raw material taken, mixing, incapsulates with every 0.3g dosage, packs.
Claims (4)
1. treat a Chinese and western medicinal composition for gastric cancer, it is characterized in that wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 ~ 3 parts, Rhizoma Paridis 5 ~ 10 parts, Fructus Camptothecae Acuminatae 3 ~ 5 parts, Radix Actinidiae Chinensis 3 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 3 parts, Rhizoma Smilacis Chinensis 2 ~ 3 parts, Shell of Water Chestnut 5 ~ 10 parts, Radix Astragali 10 ~ 20 parts, Rhizoma Alpiniae Officinarum 3 ~ 5 parts, 3 ~ 5 parts, Radix Glycyrrhizae; Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5 ~ 10 parts, α-mannatide 4 ~ 6 parts, polysaccharide-peptide 4 ~ 6 parts.
2. the Chinese and western medicinal composition for the treatment of gastric cancer as claimed in claim 1, is characterized in that wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts, Radix Glycyrrhizae.
3. the Chinese and western medicinal composition for the treatment of gastric cancer as claimed in claim 1 or 2, is characterized in that wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
4. the method for the Chinese and western medicinal composition of preparation treatment as claimed in claim 1 gastric cancer, is characterized in that being made up of following steps: 1, take raw material of Chinese medicine by above-mentioned parts by weight, cleans, for subsequent use after dry, ultraviolet-sterilization; 2, take Western medicine raw material by above-mentioned parts by weight, wear into fine powder for subsequent use; 3, the raw material of Chinese medicine weighed up is added 5 ~ 10 times amount soak by water 1 ~ 3 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spraying dry, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing; 4, add the Western medicine raw material taken, mixing, incapsulates with every 0.3 ~ 0.6g dosage, packs.
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Cited By (3)
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| CN104940748A (en) * | 2015-06-09 | 2015-09-30 | 林正兴 | Medicine composition for treating gastric cancer |
| CN104958537A (en) * | 2015-07-31 | 2015-10-07 | 山东省立医院 | Traditional Chinese medicinal composition for treating stomach cancer and preparation method thereof |
| CN107714732A (en) * | 2016-12-16 | 2018-02-23 | 四川好医生攀西药业有限责任公司 | A kind of medicine containing American cockroach and capecitabine and its application |
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| JPS61249929A (en) * | 1985-04-25 | 1986-11-07 | Koichi Sakurai | Production of herb drink effective to gastric cancer and gastric ulcer and the like |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104940748A (en) * | 2015-06-09 | 2015-09-30 | 林正兴 | Medicine composition for treating gastric cancer |
| CN104958537A (en) * | 2015-07-31 | 2015-10-07 | 山东省立医院 | Traditional Chinese medicinal composition for treating stomach cancer and preparation method thereof |
| CN107714732A (en) * | 2016-12-16 | 2018-02-23 | 四川好医生攀西药业有限责任公司 | A kind of medicine containing American cockroach and capecitabine and its application |
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Application publication date: 20150304 |