CN102552638A - Anticancer drug, as well as preparation method and application of same - Google Patents
Anticancer drug, as well as preparation method and application of same Download PDFInfo
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Abstract
The invention relates to an anticancer drug, as well as a preparation method and application of the drug. The anticancer drug is prepared by the following raw material drugs in parts by weight: 10-15 parts of radices trichosanthis, 15-25 parts of houttuynia cordata, 30-50 parts of adenophora stricta, 20-50 parts of astragalus mongholicus, 10-25 parts of medlar, 20-50 parts of sculellaria barbata, 30-50 parts of wisteria, 20-50 parts of oldenlandia diffusa, 10-15 parts of liquorice and 20-50 parts of paris polyphylla. The invention further provides a method for preparing the anticancer drug and an application in preventing cancer. The anticancer drug provided by the invention has remarkable preventing and curing effects on a plurality of cancers; and the most remarkable characteristic of the anticancer drug is that the cure rate of cancer patients using the drug reaches 10.4% and the overall effective rate is 95%.
Description
Technical field
The present invention relates to medical technical field, particularly is crude drug with Chinese medicine, made a kind of anticarcinogen.
Background technology
Cancer is the important killer who threatens the human life healthy.World Health Organization's latest data shows that before the year two thousand twenty, global cancer morbidity will increase by 50%, promptly will increase 1,500 ten thousand cancer patients every year newly.Moreover, the death toll of cancer also rapidly rises in the whole world, and the whole world in 2007 has 7,600,000 people and dies from cancer, and the year two thousand thirty, this numeral may increase to 13,200,000.And the New Development cancer patient in the whole world 20% is in China, and 24% cancer mortality patient is in China.Therefore, the prevention of cancer and treatment are the important subject that medical circle is needed solution badly.But treatment for cancer still is a global difficult problem, and cancer is prevented and treated in countries in the world all trying to explore active and effective means.
In recent years, a large amount of clinical experimental study results show that Chinese medicine and combination medicine effect aspect tumor prevention and treatment is remarkable, have become the important means of cancer clinical treatment and research.But existing few to treatment and prevention of tumour obvious results Chinese medicine, and can not be used for multiple treatment for cancer, can not satisfy pressing for of treatment and prevention of tumour research and development.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, providing a kind of is crude drug with Chinese medicine, multiple cancer is all had a kind of anticarcinogen of remarkable prevention and therapeutic effect.
The technical scheme that the present invention adopts is:
A kind of anticarcinogen; In parts by weight, process: Radix Trichosanthis 10-15 part, Herba Houttuyniae 15-25 part, Radix Adenophorae (Radix Glehniae) 30-50 part, Radix Astragali 20-50 part, Fructus Lycii 10-25 part, Herba Scutellariae Barbatae 20-50 part, Caulis wisteriae sinensis 30-50 part, Herba Hedyotidis Diffusae 20-50 part, Radix Glycyrrhizae 10-15 part, Rhizoma Paridis 20-50 part by the crude drug that comprises following component.
Preferably; Anticarcinogen of the present invention is processed by the crude drug that comprises following component in parts by weight: 15 parts of Radix Trichosanthis, 25 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 50 parts of the Radixs Astragali, 25 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 50 parts in Caulis wisteriae sinensis, 50 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 50 parts of Rhizoma Paridis.
Following in the face of the Chinese crude drug introduction that the present invention relates to down:
Radix Trichosanthis: call radices trichosanthis, pollen, building root, BAIYAO, timely snow, day melon powder, dung melon root, Chinese juniper beach wormwood powder, beach wormwood powder, derive from the dry root of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms, have effects such as clearing away heat and promoting production of body fluid, detumescence and apocenosis; Cure mainly the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst; Sore swollen toxin etc.; Experiment in vitro shows that trichosanthin can suppress HIV (HIV) duplicating in the immunocyte that infects, and reduces the viable count that is infected by the virus in the immunocyte;
Herba Houttuyniae: the another name folding basal part of the ear, smelly dish, Herba Houttuyniae, smelly grass, Herba laggera, Zhu's skin encircle; Derive from the dry above water of Saururaceae herbaceos perennial Herba Houttuyniae; Have effects such as heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, cure mainly that lung abscess vomiting pus, expectorant dyspnea of heat type are coughed, larynx Oh, hematodiarrhoea, carbuncle sore tumefacting virus, pyretic stranguria etc.;
Radix Adenophorae (Radix Glehniae): another name Radix Adenophorae, bubble ginseng, bubble Radix Adenophorae (Radix Glehniae), derive from the root of campanulaceae Lady bell plant four leaf Radix Adenophorae (Radix Glehniae), Folium Pruni Radix Adenophorae (Radix Glehniae) or its congener, have effects such as clearing away heat and nourishing YIN, nourishing the lung to arrest cough, cure mainly tracheitis, pertussis, cough due to lung-heat, cough up phlegm yellow thick etc.;
The Radix Astragali: another name Radix Astragali, continuous stilbene, the continuous Radix Astragali, the cotton Radix Astragali, Radix astragali, Radix Astragali, arrow stilbene, the arrow Radix Astragali, Rhizoma Paridis tetraphyllae etc.; Derive from the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali; Have effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting, cure mainly that the deficiency of vital energy is weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle are difficultly burst, burst for a long time do not hold back, blood deficiency and yellow complexion, interior-heat are quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.;
Fructus Lycii: call der Bockdorn, the young thorn of red pearl, the right power of cattle, Canis familiaris L. serratd edge, Bermuda grass, Canis familiaris L. milk, derive from the fruit of the multi-branched shrub plant of Solanaceae Lycium, have spermatogenesis and mend effects such as marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing, building body; Cure mainly the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus; Impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion; Blurred vision is not clear etc., and in vitro tests shows it to people's adenocarcinoma of stomach KATo-III cell, and Chinese wolfberry carpopodium, leaf all have obvious inhibition to the human cervical carcinoma Hela cell;
Herba Scutellariae Barbatae: another name and head grass, narrow leaf Herba Scutellariae indicae, toothbrush grass, Herba Scutellariae Darbatae; Herba Scutellariae Barbatae, Herba Carpesii Cernui, Aleuritopteris argentea (Gmel.) Fee, the purple grass that connects; Little Herba Scutellariae indicae etc. derive from the dry aerial parts of labiate Herba Scutellariae Barbatae, have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, effect such as anticancer, cure mainly venom, furuncle furuncle and phyma etc.; In clinical anticancer, to use very extensively, composition compound compatibilities such as many and Herba Hedyotidis Diffusae, Herba Lobeliae Chinensis are used for the treatment of kinds of tumors, and clinical have a large amount of reports;
Caulis wisteriae sinensis: another name Zhu rattan, recruit rattan, recruit bean rattan, Chinese wistaria etc., derive from pulse family Wistaria fallen leaves and climb up by holding on to the big liana of prehensile, have detoxifcation, emesis and effect such as rush down, cure mainly and control muscles and bones aching, migratory arthralgia pain, enterobiasis etc.;
Herba Hedyotidis Diffusae: another name Herba Hedyotidis Diffusae, Herba Turczaninowiae Fastigiatae, Radix Picriae felterrae etc.; Derive from the plant of Rubiaceae cerastium; Have effects such as heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness; Cure mainly dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cancerous protuberance etc., the tumor cell of acute lymphoblastic type, granulocyte type and chronic granulocyte type is had stronger inhibitory action;
Radix Glycyrrhizae: another name Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae etc.; Derive from the root and rhizome of dicotyledon pulse family Radix Glycyrrhizae, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Have effects such as antiinflammatory, antiviral; Cure mainly various acute, chronic hepatitis, bronchitis and AIDS etc., also have functions such as anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator;
Rhizoma Paridis: another name Rhizoma Paridis, Chi stop, weigh platform root, Placenta Hominis etc., derive from liliaceous plant China Rhizoma Paridis rhizome, have heat-clearing and toxic substances removing, effects such as reducing swelling and alleviating pain; Cure mainly carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis; Snake bite and insect sting, traumatic pain etc. also can be used for cancerous protuberance;
Further, crude drug described in the present invention all picks up from the mountain area, Jilin.The mountain area, Jilin belongs to the continental monsoon climate in temperate zone, because the direction orthogonal of ground, Changbai Mountain and southeast monsoon, though very near apart from the sea of Japan, continental climate is still very remarkable.The big drying of wind in spring, summer is of short duration, and temperature is cool rainy, and autumn is nice and cool foggy, and winter very long snow more.Average annual temperature is between 2.0-7.0 ℃, and precipitation is very abundant in the district, and average annual precipitation and has the big characteristics of solid rainfall amount between the 700-1400 millimeter.Just because of this exclusive climatic environment characteristics in mountain area, Jilin, make the drug effect characteristic of crude drug have incomparable advantage than other places of production.
Said anticarcinogen is the above a dosage form of any pharmaceutics.
Described anticarcinogen can be capsule, tablet, pill, powder, infusion solution, injection, liquid agent, is preferably capsule.
The present invention also provides the method for preparing said anticarcinogen, and said method comprises the steps: to select materials → pretreatment → decoction → concentrated → powder process → mixing → preparation;
Said selecting materials is meant in parts by weight, presses following prescription weighting raw materials: Radix Trichosanthis 10-15 part, Herba Houttuyniae 15-25 part, Radix Adenophorae (Radix Glehniae) 30-50 part, Radix Astragali 20-50 part, Fructus Lycii 10-25 part, Herba Scutellariae Barbatae 20-50 part, Caulis wisteriae sinensis 30-50 part, Herba Hedyotidis Diffusae 20-50 part, Radix Glycyrrhizae 10-15 part, Rhizoma Paridis 20-50 part;
Said pretreatment is meant soaks crude drug washing back 8-12 hour;
Said decoction is meant the crude drug after soaking packed into and decocts in the extraction pot, extracts filtrating three times, and merging filtrate;
Said concentrating is meant being condensed into extractum after the merging filtrate filtration;
Said powder process is meant extract dry, pulverizing, crosses 120 mesh sieves;
Said mixing is meant the medicated powder mix homogeneously after sieving, makes into medicated powder;
Said preparation is meant processes the dosage form on a kind of pharmaceutics with the one-tenth medicated powder of a last step gained.
Preferably; In the said method for preparing anticarcinogen; Selecting materials is meant in parts by weight, presses following prescription weighting raw materials: 15 parts of Radix Trichosanthis, 25 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 50 parts of the Radixs Astragali, 25 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 50 parts in Caulis wisteriae sinensis, 50 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 50 parts of Rhizoma Paridis.
Preferably, in the said method for preparing anticarcinogen, said crude drug all picks up from the mountain area, Jilin.
The present invention also provides the application of said anticarcinogen aspect anticancer and raising immunity.
The present invention comprises pulmonary carcinoma, gastric cancer, cerebral glioma, renal carcinoma, hepatocarcinoma, esophageal carcinoma or breast carcinoma in the application of anticancer aspect.
The present invention has significant effect aspect treatment and the control cancer:
(1) makes the initial stage cancer patient eliminate tumor, all cure;
(2) make cancer patient kill cancer cell growth in mid-term, effectively disease controlling development;
(3) make the growth of patients with advanced cancer anticancer, band tumor existence 5-10;
(4) have pain relieving, hemostasis, cough-relieving, absorption ascites, hydrothorax, fall effects such as cerebral;
(5) alleviate the side effect of chemicotherapy;
The comprehensive drug of a kind of anticarcinogen of the present invention is: through various all kinds of tests, effect is obvious, early metaphase patient cure rate 10.4%, and middle and advanced stage patient effective percentage 95.3%, total effective rate are more than 95%.Use the resultant effect contrast of therapy of the present invention and other therapies to see table 1 and Fig. 1.
The contrast of table 1 therapy of the present invention and other therapies
The present invention also has significant effect aspect the raising immunity: the present invention is without any side effects, in normal person's medication 3-4 week, can in 1 year, prevent flu and infectious disease.
Introduce in the face of clinical and experimental study result of the present invention down:
One, the pharmacodynamic study of anti-experimental character tumor of the present invention
Adopt preferred version of the present invention, studied the pharmacodynamic action of a kind of anticarcinogen of the present invention respectively three kinds of experimental animal models tumor models.
A. a kind of anticarcinogen of the present invention is to the effect of T739 mouse-anti adenocarcinoma of lung LA795, and experiment carries out twice, and drug dose is 0.2g crude drug/Kg, 2g crude drug/kg.The result shows has the effect of remarkable inhibition tumor growth (0.2g/KgP＜0.05, lg/KgP＜0.01), sees table 2.
B. a kind of anticarcinogen of the present invention has remarkable inhibitory action to the pure lines white No. two mouse inoculation stomach fibrosarcoma S764 in Tianjin, and dosage is the same.The test of cure effect is best with the 1.0g/kg effect, is superior to the cyclophosphamide group, sees table 3, table 4.
C. a kind of anticarcinogen of the present invention is to the effect of ehrlich carcinoma ascitic type.Experiment is carried out three times altogether, and confirming has good antitumaous effect, can improve increase in life span, sees table 5, and the ascites tumor cell counting also confirms that it suppresses the effect of tumor cell, sees table 6.Three kinds of experimental results show: the present invention has remarkable antitumor effect.
Table 2 the present invention is to T
739Mice transplantability adenocarcinoma of lung LA
795Effect
Annotate: 1. each group compares with matched group:
*P＜0.05,
* *P＜0.01
2. using dosage of the present invention all calculates by the crude drug amount
Table 3 the present invention is to mice transplantability stomach fibrosarcoma S
784Effect (for the first time experimental result)
Annotate: 1. each group compares with matched group:
*P＞0.05,
*P＜0.05,
* *P＜0.01
2. using dosage of the present invention all calculates by the crude drug amount
Table 4 the present invention is to mice transplantability stomach fibrosarcoma S
784Effect (second and third time experimental result)
Annotate: 1. each group compares with matched group:
* *P＜0.01
2. using dosage of the present invention all calculates by the crude drug amount
Table 5 the present invention is to the effect (three batches of experimental summary fruits) of mice transplanted tumor (EAC)
Annotate: a, b compare with normal saline group and cyclophosphamide group respectively
Table 6 the present invention is to the influence (three batches of experimental summary fruits) of EAC mouse ascites oncocyte counting
Annotate: a, b compare with normal saline group and cyclophosphamide group respectively
Two, undue toxicity's experimental result of the present invention
Adopt preferred version of the present invention, warp repeatedly variable concentrations suspension (25%, 30%, 50%, 60%) is tested its animal maximum tolerated dose.Kunming mouse is used in the experiment motion, body weight 20 ± 3g, and male and female are also used.Chinese medicine suspension system needs the time spent that the present invention is mixed with the variable concentrations suspension with distilled water, and the time spent is noted shaking up.The medicine Cmax is 50% (the present invention becomes medicated powder 1g=crude drug 1g); Irritating the stomach dose is 0.2g/10g; Mice maximum tolerated dose 20g/Kg/ time, it is 0.237g/cap * 4/ time that patient takes therapeutic dose, is 0.019g/Kg/ time through conversion; Therefore the mice maximum tolerated dose of Kang Fu is 1052.6 times of HTD, and promptly the each oral dose of patient is lower than 1052.6 times of mice maximum tolerated dose.
Three, the clinical experiment of cancer patient record result
Choose patient man 68 examples altogether, women 38 examples, the oldest person 81 years old, reckling 8 years old, 64.8 years old mean age.Case is selected: pulmonary carcinoma, gastric cancer, cerebral glioma, intestinal cancer, renal carcinoma and nasopharyngeal carcinoma etc.Age and severity extent by the patient that sees and treat patients give anticarcinogen of the present invention respectively, and in the patent medicine powder content: 0.6-1.5g/ time, three times/day, three months is a course of treatment.The course of treatment, result of determination was:
11 examples of fully recovering, cure rate is 10.4% (standard: tumor and symptom all disappear)
Produce effects 34 examples: existing efficient is 32.1% (standard: tumor has dwindles, and symptom has improvement)
Effective 56 examples: effective percentage is 52.8% (standard: symptom is obviously improved, and tumor changes little)
Invalid 5 examples: inefficiency is 4.7% (standard: the equal no change of tumor and symptom)
Four, model case
Case 1
Permitted *, man 71 years old, the retired veteran cadre, in JIUYUE, 1992 because of spitting of blood after (CT examination is found the swollen thing of the visible 2.5*2.5*2.5cm of bottom right lung, and the swollen thing of the visible 2.3*2.4*2.3cm of upper left lung is got biopsy through bronchoscope, last case diagnosis: bilateral adenocarcinoma of lung.Three months rear side lung tumors and the symptom of taking medicine all disappears, and directly causes now the time more than 5 years, and patient's state of an illness of always taking medicine is steady all the time, does not have the recurrence sign.
Case 2
Bears *, man 20 years old, the brain cancer (spider cell cancer) was fallen ill from 11 years old (calendar year 2001); Give operative treatment, do not take totally because of knub position, postoperative is taken medicine, and takes so far 10 years; Do not have the other medicines treatment, the existing state of an illness does not steadily have repeatedly, and health is good, and life study is normal.
Case 3
Section * *, the woman, 54 years old, the uterus carcinoma postoperative in calendar year 2001 morbidity, adhered to taking medicine 10 years from the operative treatment postoperative, and existing stable disease does not have recurrence, and health sees, well.
Case 4
In * *, the man, 62 years old, hepatocarcinoma was fallen ill 1 year, failed operative treatment, just began to take medicine, and the existing state of an illness is steady, has checked several times that tumor gets nowhere, and life and diet are normal.
Case 5
The field * *, the woman, 54 years old, leukemia was made a definite diagnosis in April, 2009, took medicine 6 months, existing stable disease, on November 2nd, 2011 wore through bone and does bone marrow fluid result of laboratory test stable disease and get nowhere.
Case 6
The king *, the man, 63 years old, the esophageal carcinoma postoperative was suffered from esophageal carcinoma before 4 years, and because of near fast long arteries, not the cutting totally of swelling, postoperative is taken medicine immediately, and so far year surplus in the of existing 4, tumor is recurrence not, and patient is good.
Case 7
Flood *, the man, 50 years old, rectal cancer, people from Heilongjiang Province suffers from rectal cancer in December, 2010, begins to take medicine 6 months, and existing tumor disappears, and stool is normal, and health is good.
Case 8
Bent *, the woman, 59 years old, gastric cancer, people from Heilongjiang Province is diagnosed as gastric cancer in November, 2010, and 4 months tumors of taking medicine disappear, and the state of an illness does not recur so far, and health is good.
The beneficial effect that the present invention had is:
A kind of anticarcinogen of the present invention is crude drug with Chinese medicine, and multiple cancer is all had remarkable prevention and therapeutic effect; Compare with present existing medicine, its maximum characteristics are, adopt the cure rate of Drug therapy cancer patient of the present invention to reach 10.4%, and total effective rate 95% is higher than domestic similar medicine; Product of the present invention does not have toxic and side effects through overtesting; And descend with the like product comparative costs.
Description of drawings
Fig. 1 is therapy of the present invention and other therapies comparison diagram.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further.
Embodiment 1
A kind of anticarcinogen is made by the method that comprises the steps:
1,, presses following prescription weighting raw materials: 15 parts of Radix Trichosanthis, 25 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 50 parts of the Radixs Astragali, 25 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 50 parts in Caulis wisteriae sinensis, 50 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 50 parts of Rhizoma Paridis in parts by weight;
2, the crude drug that takes by weighing is carried out pretreatment, crude drug washing back was soaked 12 hours;
3, the crude drug after will soaking is packed into and is decocted in the extraction pot, extracts filtrating three times, and merging filtrate;
4, will filtrate and be condensed into extractum after filtering;
5,, cross 120 mesh sieves with extract dry, pulverizing;
6, the medicated powder mix homogeneously after will sieving promptly gets into medicated powder;
7, become medicated powder to incapsulate gained and obtain capsule.
Embodiment 2
A kind of anticarcinogen is made by the method that comprises the steps:
1,, presses following prescription weighting raw materials: 15 parts of Radix Trichosanthis, 20 parts of Herba Houttuyniae, 40 parts of Radix Adenophorae (Radix Glehniae), 40 parts of the Radixs Astragali, 20 parts of Fructus Lyciis, 40 parts of Herba Scutellariae Barbataes, 40 parts in Caulis wisteriae sinensis, 30 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 45 parts of Rhizoma Paridis in parts by weight;
2, the crude drug that takes by weighing is carried out pretreatment, crude drug washing back was soaked 10 hours;
3, the crude drug after will soaking is packed into and is decocted in the extraction pot, extracts filtrating three times, and merging filtrate;
4, will filtrate and be condensed into extractum after filtering;
5,, cross 120 mesh sieves with extract dry, pulverizing;
6, the medicated powder mix homogeneously after will sieving promptly gets into medicated powder;
7, become medicated powder to process the ingot sheet gained through Ingot pressing machine.
Embodiment 3
A kind of anticarcinogen is made by the method that comprises the steps:
1,, presses following prescription weighting raw materials: 10 parts of Radix Trichosanthis, 20 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 30 parts of the Radixs Astragali, 15 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 30 parts in Caulis wisteriae sinensis, 40 parts of Herba Hedyotidis Diffusaes, 10 parts in Radix Glycyrrhizae, 40 parts of Rhizoma Paridis in parts by weight;
2, the crude drug that takes by weighing is carried out pretreatment, crude drug washing back was soaked 8 hours;
3, the crude drug after will soaking is packed into and is decocted in the extraction pot, extracts filtrating three times, and merging filtrate;
4, will filtrate and be condensed into extractum after filtering;
5,, cross 120 mesh sieves with extract dry, pulverizing;
6, the medicated powder mix homogeneously after will sieving promptly gets into medicated powder;
7, become medicated powder to process pill gained.
The above only is preferred embodiment of the present invention, is not technical scheme of the present invention is done any pro forma restriction.Every foundation technical spirit of the present invention all still belongs in the scope of technical scheme of the present invention any simple modification, equivalent variations and modification that above embodiment did.
Claims (10)
1. anticarcinogen; It is characterized in that: said anticarcinogen is processed by the crude drug that comprises following component in parts by weight: Radix Trichosanthis 10-15 part, Herba Houttuyniae 15-25 part, Radix Adenophorae (Radix Glehniae) 30-50 part, Radix Astragali 20-50 part, Fructus Lycii 10-25 part, Herba Scutellariae Barbatae 20-50 part, Caulis wisteriae sinensis 30-50 part, Herba Hedyotidis Diffusae 20-50 part, Radix Glycyrrhizae 10-15 part, Rhizoma Paridis 20-50 part.
2. anticarcinogen according to claim 1; It is characterized in that: said anticarcinogen prescription is processed by the crude drug that comprises following component in parts by weight: 15 parts of Radix Trichosanthis, 25 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 50 parts of the Radixs Astragali, 25 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 50 parts in Caulis wisteriae sinensis, 50 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 50 parts of Rhizoma Paridis.
3. anticarcinogen according to claim 1 and 2 is characterized in that: said crude drug all picks up from the mountain area, Jilin.
4. according to the said anticarcinogen of claim 1, it is characterized in that: said anticarcinogen is the above a dosage form of any pharmaceutics.
5. according to the said anticarcinogen of claim 4, it is characterized in that: described anticarcinogen dosage form is capsule, tablet, pill, powder, infusion solution, injection or liquid agent, and preferred, said anticarcinogen dosage form is a capsule.
6. method for preparing the said anticarcinogen of claim 1 is characterized in that: said method comprises the steps: to select materials → and pretreatment → decoction → concentrate → powder process → mixing → preparation;
Said selecting materials is meant in parts by weight, presses following prescription weighting raw materials: Radix Trichosanthis 10-15 part, Herba Houttuyniae 15-25 part, Radix Adenophorae (Radix Glehniae) 30-50 part, Radix Astragali 20-50 part, Fructus Lycii 10-25 part, Herba Scutellariae Barbatae 20-50 part, Caulis wisteriae sinensis 30-50 part, Herba Hedyotidis Diffusae 20-50 part, Radix Glycyrrhizae 10-15 part, Rhizoma Paridis 20-50 part;
Said pretreatment is meant soaks crude drug washing back 8-12 hour;
Said decoction is meant the crude drug after soaking packed into and decocts in the extraction pot, extracts filtrating three times, and merging filtrate;
Said concentrating is meant being condensed into extractum after the merging filtrate filtration;
Said powder process is meant extract dry, pulverizing, crosses 120 mesh sieves;
Said mixing is meant the medicated powder mix homogeneously after sieving, makes into medicated powder;
Said preparation is meant processes the dosage form on a kind of pharmaceutics with the one-tenth medicated powder of a last step gained.
7. the method for preparing anticarcinogen according to claim 6; It is characterized in that: said selecting materials is meant in parts by weight, presses following prescription weighting raw materials: 15 parts of Radix Trichosanthis, 25 parts of Herba Houttuyniae, 50 parts of Radix Adenophorae (Radix Glehniae), 50 parts of the Radixs Astragali, 25 parts of Fructus Lyciis, 50 parts of Herba Scutellariae Barbataes, 50 parts in Caulis wisteriae sinensis, 50 parts of Herba Hedyotidis Diffusaes, 15 parts in Radix Glycyrrhizae, 50 parts of Rhizoma Paridis.
8. according to claim 6 or the 7 described methods that prepare anticarcinogen, it is characterized in that: said crude drug all picks up from the mountain area, Jilin.
9. the application of the described anticarcinogen of claim 1 aspect anticancer and raising immunity.
10. anticarcinogen according to claim 9 comprises pulmonary carcinoma, gastric cancer, cerebral glioma, renal carcinoma, hepatocarcinoma, esophageal carcinoma or breast carcinoma in the application of anticancer aspect.
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| CN104127573A (en) * | 2014-07-31 | 2014-11-05 | 河南科技大学第一附属医院 | Preparation method for pharmaceutical composition for treating breast cancer |
| CN104383519A (en) * | 2014-10-22 | 2015-03-04 | 王喜功 | Chinese and western medicine composition curing stomach cancer and preparation method for Chinese and western medicine composition |
| CN105362801A (en) * | 2014-08-28 | 2016-03-02 | 李华 | Traditional Chinese medicine for treating cancer |
| CN105381183A (en) * | 2015-11-25 | 2016-03-09 | 重庆市洪欣食用菌有限公司 | Traditional Chinese medicine composition used for suppressing breast cancer and preparation method for herb soup of traditional Chinese medicine composition |
| CN105687491A (en) * | 2016-03-23 | 2016-06-22 | 黄群德 | Traditional Chinese medicine preparation for treating cancerous protuberance |
| CN106692674A (en) * | 2017-02-22 | 2017-05-24 | 红河州丰茂农业科技发展有限公司 | Traditional Chinese medicine composition for treating esophagus cancer and laryngeal cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104127573A (en) * | 2014-07-31 | 2014-11-05 | 河南科技大学第一附属医院 | Preparation method for pharmaceutical composition for treating breast cancer |
| CN105362801A (en) * | 2014-08-28 | 2016-03-02 | 李华 | Traditional Chinese medicine for treating cancer |
| CN104383519A (en) * | 2014-10-22 | 2015-03-04 | 王喜功 | Chinese and western medicine composition curing stomach cancer and preparation method for Chinese and western medicine composition |
| CN105381183A (en) * | 2015-11-25 | 2016-03-09 | 重庆市洪欣食用菌有限公司 | Traditional Chinese medicine composition used for suppressing breast cancer and preparation method for herb soup of traditional Chinese medicine composition |
| CN105687491A (en) * | 2016-03-23 | 2016-06-22 | 黄群德 | Traditional Chinese medicine preparation for treating cancerous protuberance |
| CN106692674A (en) * | 2017-02-22 | 2017-05-24 | 红河州丰茂农业科技发展有限公司 | Traditional Chinese medicine composition for treating esophagus cancer and laryngeal cancer |
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