CN101352557B - Chinese medicine preparation for treating gastric cancer and preparation method thereof - Google Patents
Chinese medicine preparation for treating gastric cancer and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicine preparation for treating gastric cancer and a preparation method thereof. The Chinese medicine preparation is prepared by smilax glabra, oldenlandia diffusa, paris.polyphylla, herba scutellariae barbatae, astragalus, tuckahoe, rhizoma Zedoariae, medlar and Panax notoginseng, which can be made into oral solid preparation or oral liquid preparation and has the effects of strengthening the spleen and replenishing qi, promoting blood flow and nourishing the kidney, promoting blood circulation and removing blood stasis, invigorating the spleen and removing food retention. Used in the treatment of the gastric cancer, the preparation can strength the efficacy of radiation treatment and chemical treatment, can strength the immunologic function of the organism and improve the clinical symptoms of gastric cancer patients. Furthermore, the clinical testing proves that the preparation has good gastric cancer treatment effect, convenient use, safe reliability and no adverse effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of gastric cancer, particularly treat Chinese medicine preparation of gastric cancer and preparation method thereof.
Background technology:
Gastric cancer is the cancerous protuberance of seeing at most in the malignant tumor of digestive tract, and the sickness rate of gastric cancer is widely different in the country variant different regions.China belongs to the gastric cancer district occurred frequently, in the first place that its sickness rate of China occupies all kinds of tumors, there are every year 170000 people to die from gastric cancer approximately, almost near 1/4 of whole malignant tumor death tolls, and annual also have that new Patients with Gastric Cancer generates the serious threat people's health more than 20,000.Gastric cancer can betide any age, but to see 40～60 years old, the man is about 3.6:1 more than the woman more.Its pathogenic factor is not clear, may with multiple factor, relevant as living habit, dietetic variety, environmental factors, heredodiathesis, Nervous and Mental Factors etc., also with chronic gastritis, polyp of stomach, gastric mucosa special-shaped hyperplasia and intestinal epithelial metaplasia, operation after residual stomach, and long-term helicobacter pylori (HP) infects etc. certain relation is arranged.The traditional Chinese medical science thinks that primary disease is that chronic dietary does not save, feelings will is unsuccessful, overstrain internal injury or being invaded by exogenous pathogen, causes the liver failing to maintain the normal flow of QI, stomach-QI being unable to descend normally, or the prolonged illness taste are impaired, give birth in the phlegm-damp, and qi depression to blood stasis is condensed in stomach and forms.Say as " General Treatise on the Cause and Symptoms of Diseases ": " disorder of YIN and YANG, then three warmers are isolated, and three warmers are isolated, and then body fluid is unfavorable, so make vent plug uncomfortable, is to choke with one-tenth.Due to this was angerd by melancholy, melancholy was angerd depressed, did not depressedly then declare stream, and made the dysphagia also obstructed "." special effect good recipe regurgitation of food from the stomach door " meaning: " husband regurgitation person, this stomach.How satisfy because of the gastric qi choosing, the wound of drinking, or long-pending wind and cold, or because of the sad calamity of being worried, or angry depressed because of holding, the dyspepsia addiction is gathered cold phlegm, movingly disturbs taste, can not wear down paddy a little less than the stomach and eat, and satisfies into this disease ".The traditional Chinese medical science is often with heat-clearing and toxic substances removing, and strengthening vital QI to eliminate pathogenic factors, invigorating the spleen and regulating the stomach, benefiting vital QI and blood are method, reach the purpose of treatment.
To the treatment of gastric cancer, operation, chemotherapy are still the main method of present treatment gastric cancer.But operation can damage the internal organs organ, causes wound hemorrhage; Chemotherapy lacks selectivity, and toxic and side effects is bigger, and body's immunity is had damaging action.If cancer is not utterly destroyed as yet, alleviate even reach for the moment, still can recur rapidly or shift.And Chinese medicine not only can promote physical recovery in treatment gastric cancer, raise immunity, and can bring into play antitumaous effect, prevent recurrence and shift the raising survival rate.In addition, for forfeiture operative treatment chance, should not or be unwilling to carry out the patients with terminal of chemotherapy again, also can obtain certain curative effect with Chinese medicine, especially alleviating clinical symptoms, improve life quality, the characteristic of Chinese medicine has been brought into play in prolongation aspect life cycle.Therefore, in the treatment of gastric cancer, actively use the Chinese medicine technology, it is very necessary combining with operation, chemotherapy.Simultaneously, develop and develop effective Chinese medicine preparation and treat gastric cancer, the hygiene medical treatment cause of China is had crucial meaning.
Summary of the invention
Inventor system is from the rule of treatment of Chinese traditional treatment gastric cancer, through development test, by Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor medicines, through suitable processing, the process of preparing Chinese medicine, extraction, make a kind of effective Chinese medicine preparation for the treatment of gastric cancer.
The Chinese medicine preparation that the present invention treats gastric cancer is to be made by the raw material of following parts by weight:
Rhizoma Smilacis Glabrae 50-75 Herba Hedyotidis Diffusae 50-75 Rhizoma Paridis 25-40
Herba Scutellariae Barbatae 10-25 Radix Astragali 10-25 Poria 20-45
Rhizoma Curcumae 10-20 Fructus Lycii 5-15 Radix Notoginseng 10-25.
Relevant above medicine by retrieval, is found relevant part document and is described below as the report of Chinese medicine preparation treatment tumor:
1, the antitumor action of [autograph] smilax glabra total Saponin research [author] Qiu Guangqing; Xu Lian is good; Lin Jiena; Zhang Min [mechanism] Guangdong Prov. Inst. of Materia Medica; , [periodical name] Pharmacology and Clinics of Chinese Materia Medica, 2001, (05) [digest] purpose: research smilax glabra total Saponin (SGR) is in vivo and in vitro to the inhibitory action of zoopery tumor.Method: select ehrlich carcinoma (EAC), interior tumor S180 and hepatocarcinoma (H22) for the strain of experiment tumor, adopt tumor cell in vitro to cultivate and the in-vivo tumour implantation method, observe cytotoxicity, tumor control rate and the increase in life span of SGR.Result: SGR is respectively 17.6 μ g/ml, 48.6 μ g/ml and 35.4 μ g/ml to EAC, the S180 of In vitro culture and the half-inhibition concentration (IC50) of H22 cell; SGR1.5g/kg, 3g/kg are respectively 29.9% and 30.3% to the tumour inhibiting rate of S180 solid tumor; SGR0.75g/kg, 1.5g/kg, 3g/kg are respectively 11.7%, 10.3% and 5.1% to the tumour inhibiting rate of H22; SGR0.5g/kg, 1g/kg, 2g/kg to tumor-bearing mice EAC and SGR1.5g/kg, 3g/kg to life cycle of S180 mice all less than obviously influence.
2, [autograph] Herba Hedyotidis Diffusae treatment malignant tumor [author] Luo Xin [mechanism] Sanya, Hainan Province institute of traditional Chinese medicine, [periodical name] Journal of Traditional Chinese Medicine, 2007, (03) [digest] is main prescription therapeutic malignant tumor with Herba Hedyotidis Diffusae, and be evident in efficacy.Substantially square: Herba Hedyotidis Diffusae 30～100g, Herba Scutellariae Barbatae 30g, Radix Astragali 30g, Ganoderma 10g, Radix Rehmanniae 30g.The dry stool person of being difficult to resolve adds Radix Et Rhizoma Rhei 10g, Fructus Aurantii Immaturus 10g, Cortex Magnoliae Officinalis 10g, Radix Scrophulariae 30g, Radix Ophiopogonis 30g.Pulmonary carcinoma adds Herba Houttuyniae 20g, Bulbus Fritillariae Thunbergii 20g; Hepatocarcinoma adds Rhizoma Corydalis 15g, Herba Hyperici Japonici 30g; Esophageal carcinoma, gastric cancer add Radix Sophorae Tonkinensis 12g, Rhizoma Paridis 30g, Fructus Trichosanthis 30g, Radix Clematidis 30g; Leukemia, malignant lymphoma add Indigo Naturalis 10g, Realgar 015g; Breast carcinoma adds Radix Trichosanthis 10g, Pseudobulbus Cremastrae Seu Pleiones 10g, Pericarpium Citri Reticulatae Viride 10g.1 dose of every day.
3, preliminary study [author] the Cui Yan .[mechanism of [autograph] extract antitumor action] Yanbian University's [periodical name] Chinese outstanding master thesis full-text database [digest] purpose: the antitumor action of preliminary study Herba Hedyotidis Diffusae extract and the mechanism of action thereof.Method: calculate chmice acute per os LD_ (50) and 95% confidence region limit thereof with the HornShi method; Irritate stomach with Herba Hedyotidis Diffusae extract and observe it wanting _ inhibitory action of (180) tumor-bearing mice tumor; Adopt MTT cell in vitro poison laboratory observation Herba Hedyotidis Diffusae extract to human leukemia K_ (562) cell strain antiproliferative effect; Adopt the serum pharmacological experimental technique, observe of the influence of pastille serum human cervical carcinoma Hela cell's strain multiplication capacity; Adopt colorimetric method for determining tumor-bearing mice serum activity of SOD and MDA content.The result: 1, acute toxicity testing result, the chmice acute per os LD (50) of Herba Hedyotidis Diffusae extract and 95% fiducial limit thereof are female to be that (489-1290mg/kg), male be 909mg/kg (546-1510mg/kg) to 794mg/kg.2, Herba Hedyotidis Diffusae extract little, in, heavy dose of group is respectively 32.23%, 34.40%, 35.54% to the tumour inhibiting rate of mouse transplanted sarcoma S_ (180) solid tumor, there is significant inhibitory effect (to compare with model group, small dose group P＜0.05, in, heavy dose of group P＜0.01).3, MTT cell in vitro poison experimental result: the Herba Hedyotidis Diffusae extract that concentration is respectively 20 μ g/ml, 40 μ g/ml and 80 μ/ml is respectively 53.12%, 82.74%, 98.27 to the proliferation inhibition rate of K_ (562) cell strain.
4, the different extraction processes of [autograph] Herba Hedyotidis Diffusae are to influence [author] Zhao Haoru of anti-tumor activity, Li Rui, Lin Yining, old is woods .[mechanism] Chinese medicine institute of China Medicine University [periodical name] China Medicine University's journal, 2002, (06) [digest] purpose is determined the antitumor action of different Herba Hedyotidis Diffusae extracts (decoction, lipophilic extract, crude polysaccharides) for developing low toxicity anticancer preparation efficiently.Method employing water extraction method, alcohol extraction are followed the example of, the defat decoction and alcohol sedimentation technique has prepared Herba Hedyotidis Diffusae decoction, lipophilic extract and crude polysaccharides respectively.Implant mice as model with the S-180 cell, carried out suppressing the test of tumor.The water extract (decoction) of Herba Hedyotidis Diffusae does not have the obvious suppression effect to the S-180 tumor cell as a result; Water miscible polysaccharide of Herba Hedyotidis Diffusae and lipophilic extract have significant inhibitory effect to the S-180 tumor cell; When pressing down tumor, polysaccharide partly has the protective effect to chemical damage; Water miscible polysaccharide and lipophilic extract merge administration and do not show the synergistic antitumor activity.Fat-soluble position of conclusion Herba Hedyotidis Diffusae and polysaccharide have good antitumor application prospect, extract more effective than simple water extraction respectively.
5, progress [author] Zhang Haifang of [autograph] Herba Scutellariae Barbatae chemical constituent and biologic activity, permitted small stream ..[mechanism] biological and environmental project institute [periodical name] the Jiangsu University's journal (medicine) of Jiangsu University, 2006, (01) [digest] Herba Scutellariae Barbatae (Scutellaria barbata D.Don) another name and head grass, little Herba Scutellariae indicae, toothbrush grass, longleaf rabdosia stem etc., be the Labiatae Astragalus, herb can be used as medicine, main product in Jiangsu, ground such as Jiangxi, Fujian, Guangdong and Guangxi.Its property mildly bitter flavor, cold have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain and function such as anticancer, and China often is used for the treatment of Herba Scutellariae Barbatae various cancers such as rectal cancer, pulmonary carcinoma, lymphatic cancer etc.
Adopt Rhizoma Smilacis Glabrae having in the Chinese medicine preparation of Chinese patent database introduction treatment cancer, gastric cancer as raw material:
Application number 95108065.2, cancer therapy drug and preparation method thereof; Application number: 94113805.4, Chinese medicine medicine for preventing " Bisikang " capsule and manufacture method thereof; Application number: 94107649.0, clear cigarette Jiedu oral liquid and preparation method thereof; Application number: 95110809.3, a kind of anticancer Chinese patent medicine and production method; Application number: 01135125.X, antitumor oral liquid and preparation method thereof; Application number: 01118222.9, a kind of Chinese medicine composition for the treatment of cancer; Application number: 200410018779.6, a kind of Chinese medicine medicine for preventing composition and method of making the same; Application number: 200410073873.1, a kind of Chinese medicine with anti-cancer and kill cancer action; Application number: 200510012306.X, the medicine of a kind of inhibition and elimination cancer; Application number: 200410020629.9, a kind of anticarcinogen; Application number: 200610018696.6, compound dioecious balanophora herb capsule; Application number: 200510079718.5, tumor-inhibiting anticancer oral liquid.
With the Herba Hedyotidis Diffusae is having of feedstock production cancer therapy drug: application number: 02138103.8, and Renshujianwei granules stomachia and preparation method thereof; Application number: 01128204.5, a kind of pure Chinese medicinal preparation and preparation method for the treatment of human primary gastrointestinal cancers; Application number: 93100223.0, the manufacture method of a kind of anticancer prescription and preparation thereof; Application number: 93110894.2, " gan shi xin " oral liquid; Application number: 92101928.9, the compound method of anti-cancer chrysanthemum-jujube tea; Application number: 92105481.5, a kind of production method of cancer-preventing health food; Application number: 93117565.8, oral liquid for curing cancer; Application number: 93111493.4, Chinese herbal medicine " keaiji " for curing cancer and preparation method thereof etc.
With the Rhizoma Paridis is having of feedstock production cancer therapy drug:
Application number: 02133299.1, antitumor and prevention and curing health care liquid, powder; Application number: 02114109.6, a kind of new drug for the treatment of pulmonary carcinoma; Application number: 02117062.2, anti-cancer capsule and preparation method thereof; Application number: 95112116.2, Sanzhu Body Resistance Strengthening and Anticancer Oral Liquid and preparation method thereof; Application number: 96105287.2, a kind of anti AIDS virus and anticancer pharmaceutical composition; Application number: 96119639.4, Aifukang electuary and preparation method thereof; Application number: 97100988.0, Aikeping-medicine for treating cancer; Application number: 93100223.0, the manufacture method of a kind of anticancer prescription and preparation thereof; Application number: 94104938.8, the cancer that disappears spirit; Application number: 94114880.7, oral liquid for treatment of cancer and method for making thereof.
With Herba Hedyotidis Diffusae and Rhizoma Smilacis Glabrae serves as that the while patent application of feedstock production cancer therapy drug has:
Application number: 94113805.4, Chinese medicine medicine for preventing " Bisikang " capsule and manufacture method thereof; Application number: 99101136.8, a kind of medicine for the treatment of hepatocarcinoma; Application number: 01118222.9, a kind of Chinese medicine composition for the treatment of cancer; Application number: 200410018779.6, a kind of Chinese medicine medicine for preventing composition and method of making the same; Application number: 200510069839.1, a kind of Chinese medicine for the treatment of hepatitis B etc.
Be all the anticancer medicine of feedstock production with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis and do not see that open report is arranged.
Recognize from above-mentioned searching document, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis all are that the traditional Chinese medical science more often adopts the medical material for the treatment of malignant tumor (cancer), before the present invention, also carried out the research of some pharmacology, clinicing aspect, but the content of being studied is with of the present invention different.
The present invention carried out more deep research again, and has tested some Chinese herbal medicine, and made compound preparation in early stage that Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis can be treated cancer on the basis.The research situation division of effect that Chinese medicine of the present invention is relevant and document ancient books, experience or modern relevant this kind is as follows:
This preparation has the merit of invigorating the spleen and benefiting QI, blood circulation promoting nourishing kidney, blood circulation promoting and blood stasis dispelling, spleen invigorating removing food stagnancy, is used for the treatment of gastric cancer.Rhizoma Smilacis Glabrae in the side, sweet, light, flat.Return liver, stomach warp.The tool dehumidifying, detoxifcation, easing joint movement effect.The Herba Hedyotidis Diffusae slightly sweet flavor, cool in nature.The effect heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation.Rhizoma Paridis has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Herba Scutellariae Barbatae is cold in nature, acrid in the mouth, hardship.Function cures mainly heat-clearing and toxic substances removing, the blood stasis dispelling diuresis.Be used for furuncle swelling toxin, laryngopharynx swelling and pain; The Radix Astragali, sweet in the mouth, slightly warm in nature is returned the lung spleen channel, function air making-up and spleen enlivening, nourishing qi to stop., Poria slightly sweet flavor, property be flat; Gui Jing: GUIXIN, lung, spleen channel; Effect: spleen invigorating, calm the nerves, calm, diuresis, also can promote health immunocompetence, Rhizoma Curcumae bitter in the mouth suffering, temperature is used for the removing blood stasis circulation of qi promoting, the removing food stagnancy pain relieving; Fructus Lycii property is sweet, flat, returns the Liver and kidney warp, has nourishing the liver and kidney, the effect of nourishing the liver to improve visual acuity, Radix Notoginseng sweet in the mouth, and little hardship, warm in nature, return liver, stomach, the heart, lung, large intestine channel.The merit that hemostasis, dissipating blood stasis, detumescence, analgesic therapy are arranged.
More than all medicines share, play the merit of invigorating the spleen and benefiting QI, blood circulation promoting nourishing kidney, blood circulation promoting and blood stasis dispelling, spleen invigorating removing food stagnancy altogether, be used for the treatment of gastric cancer, can strengthen the curative effect of radiotherapy, chemotherapy, the enhancing human body immunity function; Can improve the patients with gastric cancer clinical symptoms.
Chinese medicine preparation of the present invention can make oral solid formulation or oral liquid, the production method of these two kinds of preparations is as follows:
(1) oral solid formulation is with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 8-15 times boils three times, each 1-2 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 50-70%, stir, left standstill 12-24 hour, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), add right amount of auxiliary materials by different preparation manufacture methods, make granule, tablet or capsule, soft extract, pill, medicinal tea, powder, solid preparations such as drop pill, packing are promptly.
(2) oral liquid is that Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 8-15 times boils three times, each 1-2 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 50-70%, stir, left standstill 12-24 hour, filter, decompression recycling ethanol, and simmer down to clear paste add right amount of auxiliary materials, make corresponding liquid oral dosage form by formulation method, packing promptly.
Described adjuvant comprises the adjuvant commonly used, sugar-free sweetener, antiseptic of various medical standard universals etc., and sweeting agent commonly used comprises sucrose etc.Sugar-free sweetener comprises stevioside and sweeting agents such as protein sugar, xylitol, high fructose and cyclamate, and antiseptic comprises sodium benzoate, benzoic acid, Nipagin ester etc.
The specific embodiment
Embodiment 1.
Rhizoma Smilacis Glabrae 50g Herba Hedyotidis Diffusae 50g Rhizoma Paridis 25g
Herba Scutellariae Barbatae 10g Radix Astragali 25g Poria 45g
Rhizoma Curcumae 20g Fructus Lycii 15g Radix Notoginseng 25g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, adding 8 times of decoctings boils three times, each 2 hours, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), adds ethanol to containing alcohol amount 60%, stirs, left standstill 24 hours, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), 80 ℃ of drying under reduced pressure, pulverize, adding starch is an amount of, makes tablet.
Embodiment 2.
Rhizoma Smilacis Glabrae 75g Herba Hedyotidis Diffusae 75g Rhizoma Paridis 40
Herba Scutellariae Barbatae 25g Radix Astragali 10g Poria 20g
Rhizoma Curcumae 10g Fructus Lycii 5g Radix Notoginseng 10g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 14 times boils three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.12 (80 ℃), adds ethanol to containing alcohol amount 70%, stirs, left standstill 12 hours, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.27-1.30 (60 ℃), 80 ℃ of drying under reduced pressure, pulverize, adding Flos Chrysanthemi Icing Sugar is an amount of, makes granule.
Embodiment 3.
Rhizoma Smilacis Glabrae 60g Herba Hedyotidis Diffusae 60g Rhizoma Paridis 30g
Herba Scutellariae Barbatae 20g Radix Astragali 20g Poria 30g
Rhizoma Curcumae 15g Fructus Lycii 10g Radix Notoginseng 20g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 15 times boils three times, each 1.5 hours, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), adds ethanol to containing alcohol amount 70%, stirs, left standstill 12 hours, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), 85 ℃ of drying under reduced pressure, pulverize, the adding dextrin is an amount of, makes medicinal tea.
Embodiment 4.
Rhizoma Smilacis Glabrae 60g Herba Hedyotidis Diffusae 60g Rhizoma Paridis 30g
Herba Scutellariae Barbatae 15g Radix Astragali 15g Poria 30g
Rhizoma Curcumae 15g Fructus Lycii 10g Radix Notoginseng 15g.
Method for making: with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 10 times boils three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), adds ethanol to containing alcohol amount 70%, stirs, left standstill 18 hours, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), behind glyceryl monostearate heating and melting mixing, splash in the not miscible condensed fluid, shrink condensation and make sphere or the spheric preparation of class, packing promptly.
Embodiment 5.
Rhizoma Smilacis Glabrae 70g Herba Hedyotidis Diffusae 60g Rhizoma Paridis 25g
Herba Scutellariae Barbatae 10g Radix Astragali 25g Poria 20g
Rhizoma Curcumae 10g Fructus Lycii 5g Radix Notoginseng 10g.
Method for making: with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 12 times boils three times, each 1 hour, collecting decoction filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 70%, stir, left standstill 24 hours, filter, decompression filtrate recycling ethanol, and being concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), 75 ℃ of drying under reduced pressure are pulverized, add cane sugar powder, mixing, briquetting or adorn tea bag or fry in shallow oil in the bag then, packing is promptly.
Embodiment 6.
Rhizoma Smilacis Glabrae 50g Herba Hedyotidis Diffusae 50g Rhizoma Paridis 25g
Herba Scutellariae Barbatae 10g Radix Astragali 10g Poria 20g
Rhizoma Curcumae 10g Fructus Lycii 5g Radix Notoginseng 10g.
Method for making: with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 9 times boils three times, each 1 hour, collecting decoction filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 70%, stir, left standstill 24 hours, filter, decompression filtrate recycling ethanol, and being concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), 85 ℃ of drying under reduced pressure are pulverized, it is an amount of to add starch, mixing is divided in Capsules or is sealed in the soft capsule material, and packing promptly.
Embodiment 7.
Rhizoma Smilacis Glabrae 75g Herba Hedyotidis Diffusae 75g Rhizoma Paridis 40g
Herba Scutellariae Barbatae 25g Radix Astragali 25g Poria 45g
Rhizoma Curcumae 20g Fructus Lycii 15g Radix Notoginseng 25g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 13 times boils three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 70%, stir, left standstill 12 hours, filter, decompression filtrate recycling ethanol, and be concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), add refined honey and receive cream, add the 7.5mg sodium benzoate, packing promptly.
Embodiment 8.
Rhizoma Smilacis Glabrae 55g Herba Hedyotidis Diffusae 55g Rhizoma Paridis 25g
Herba Scutellariae Barbatae 15g Radix Astragali 15g Poria 25g
Rhizoma Curcumae 20g Fructus Lycii 15g Radix Notoginseng 10g.
Method for making: with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, the decocting that adds 11 times boils three times, each 1 hour, collecting decoction filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 50%, stir, left standstill 24 hours, filter, decompression filtrate recycling ethanol, and being concentrated into the clear paste that relative density is 1.25-1.35 (60 ℃), 80 ℃ of drying under reduced pressure are pulverized, appropriate amount of starch, mixing, water with 5% and Mel are done binding agent and are prepared into ball, and packing is promptly.
Embodiment 9.
Rhizoma Smilacis Glabrae 50g Herba Hedyotidis Diffusae 50g Rhizoma Paridis 40g
Herba Scutellariae Barbatae 25g Radix Astragali 10g Poria 25g
Rhizoma Curcumae 20g Fructus Lycii 15g Radix Notoginseng 15g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, and the decocting that adds 15 times boils three times, each 2 hours, collecting decoction filters, and it is the 1.10-1.15 clear paste that filtrate is condensed into relative density, add ethanol to containing alcohol amount 50%, stir, left standstill 14 hours, filter, decompression filtrate recycling ethanol, and to be concentrated into relative density be that 1.25-1.35 is clear paste (60 ℃), and it is an amount of to add sucrose, makes mixture.
Embodiment 10.
Rhizoma Smilacis Glabrae 75g Herba Hedyotidis Diffusae 75g Rhizoma Paridis 25g
Herba Scutellariae Barbatae 25g Radix Astragali 25g Poria 20g
Rhizoma Curcumae 20g Fructus Lycii 15g Radix Notoginseng 10g.
Method for making: Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, and the decocting that adds 14 times boils three times, each 2 hours, collecting decoction filters, and it is the 1.10-1.15 clear paste that filtrate is condensed into relative density, add ethanol to containing alcohol amount 62%, stir, left standstill 24 hours, filter, decompression filtrate recycling ethanol, and the simmer down to clear paste, adding sucrose is an amount of, makes syrup.
Substantive distinguishing features of the present invention and obvious improvement are:
1, adopt invigorating the spleen and benefiting QI, blood circulation promoting nourishing kidney to be that the main rule of treatment is treated gastric cancer, and to obtain curative effect preferably.
2, reasonable recipe: with the more Chinese crude drug Rhizoma Smilacis Glabrae of clinical research, Herba Hedyotidis Diffusae, Rhizoma Paridis is principal agent, 5 with spleen invigorating, QI invigorating, nourishing kidney, the Chinese crude drug of invigorating blood circulation, play the merit of invigorating the spleen and benefiting QI, blood circulation promoting nourishing kidney altogether, reach eliminating pathogenic factor for supporting vital QI, the purpose of treatment gastric cancer and prevention stomach cancer metastasis.
3, the present invention prepares easily, onset is very fast, has no side effect.
The present invention treats the pharmacological research of the Chinese medicine preparation of gastric cancer:
Pharmacodynamics test shows, extracting solution handler gastric cancer SGC one 7910 cells of the compositions of the present invention of variable concentrations, different time, mtt assay is measured the cell proliferation situation, and flow cytometry analysis cell cycle, apoptosis and proliferating cell nuclear antigen (PCNA), c-Myc, Bcl 1 express.The present invention as a result extracts the spy can suppress SGC one 7910 cell proliferation, and suppression ratio and concentration are dependence; Cell cycle G0/G1 phase, S phase ratio increase, pharmaceutical composition energy cell death inducing of the present invention, and apoptosis rate and time, dosage are dependence; PCNA, c after the effect of the present invention-
, Bcl 1 expresses significantly downward modulation (P＜0.05 or P＜0.01), conclusion pharmaceutical composition of the present invention can suppress SGC one 7910 cell proliferation, induces its apoptosis; Its mechanism of action may be relevant with the expression of downward modulation PCNA, c-Myc, Bcl 1.
Test shows: what pharmaceutical composition of the present invention can significantly suppress gastric carcinoma cells and FN sticks, suppresses cell movement and invasion and attack (P＜0.05 or P＜0.01), and suppression ratio and dosage are dependence; Pharmaceutical composition of the present invention can significantly reduce the content (P＜0.01) of gastric carcinoma cells MMP 1 and MMP 1 and be dependence with dosage.Conclusion: pharmaceutical composition of the present invention can suppress the gastric carcinoma cells invasive ability, and its mechanism may to reduce the content of gastric carcinoma cells MMP 1 and MMP 1 relevant with the present invention.
The present invention treats the clinical pilot study of gastric cancer:
With the granule of the present invention's preparation, early stage patient carries out clinical prerun to gastric cancer, gives qualified patient each 1 bag, 3 times on the one, judges by clinical protocol: 26 examples of wherein fully recovering, produce effects 2 examples, effective 1 example, total obvious effective rate 96.7%, total effective rate 100%.Show in the clinical trial that the present invention can improve the patients with gastric cancer clinical symptoms, strengthen patient's immunity.
Give granule of the present invention to the Patients with Gastric Cancer after the 2 routine chemotherapy, every day 3 times, each 1 bag, the side reaction behind the 2 routine chemotherapy of patients all reduces clinical symptom relief.
This medicine does not have untoward reaction to occur in clinical prerun.
Claims (4)
1. Chinese medicine preparation for the treatment of gastric cancer is characterized in that: the raw materials of effective components of making Chinese medicine preparation is formed and is by weight:
Rhizoma Smilacis Glabrae 50-75 Herba Hedyotidis Diffusae 50-75 Rhizoma Paridis 25-40
Herba Scutellariae Barbatae 10-25 Radix Astragali 10-25 Poria 20-45
Rhizoma Curcumae 10-20 Fructus Lycii 5-15 Radix Notoginseng 10-25.
2. the Chinese medicine preparation of treatment gastric cancer according to claim 1 is characterized in that: this Chinese medicine preparation is made oral solid formulation or oral liquid.
3. the production method of the Chinese medicine preparation of treatment gastric cancer as claimed in claim 2, it is characterized in that: oral solid formulation is with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, adding 8-15 decocting doubly boils three times, each 1-2 hour, collecting decoction, filter, relative density was the clear paste of 1.10-1.15 when filtrate was condensed into 80 ℃, add ethanol to containing alcohol amount 50-70%, stir, left standstill 12-24 hour, and filtered decompression filtrate recycling ethanol, and relative density is the clear paste of 1.25-1.35 when being concentrated into 60 ℃, add right amount of auxiliary materials by different preparation manufacture methods, make granule, tablet or capsule, soft extract, pill, medicinal tea, powder, drop pill solid preparation, packing are promptly.
4. the production method of the Chinese medicine preparation of treatment gastric cancer as claimed in claim 2, it is characterized in that: oral liquid is with Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae, Rhizoma Paridis, Herba Scutellariae Barbatae, the Radix Astragali, Poria, Rhizoma Curcumae, Fructus Lycii, Radix Notoginseng nine flavor Chinese medicines are got the raw materials ready, adding 8-15 decocting doubly boils three times, each 1-2 hour, collecting decoction, filter, relative density was the clear paste of 1.10-1.15 when filtrate was condensed into 80 ℃, added ethanol to containing alcohol amount 50-70%, stir, left standstill 12-24 hour, and filtered decompression recycling ethanol, and simmer down to clear paste, add right amount of auxiliary materials, make corresponding liquid oral dosage form by formulation method, packing promptly.
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| CN101773648B (en) * | 2010-04-08 | 2011-06-15 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating gastric cancer and preparation method thereof |
| CN105362801A (en) * | 2014-08-28 | 2016-03-02 | 李华 | Traditional Chinese medicine for treating cancer |
| CN104189846A (en) * | 2014-09-18 | 2014-12-10 | 陈远征 | Traditional Chinese medicine composition used as radiotherapy and chemotherapy sensitizing agent and preparation method thereof |
| CN104800740A (en) * | 2015-05-07 | 2015-07-29 | 王小华 | Medicinal food suitable for gastric carcinoma patient to administrate and preparation method of medicinal food |
| CN105168658A (en) * | 2015-10-08 | 2015-12-23 | 谭真 | Traditional Chinese medicine preparation for treating stomach cancer and preparation method of traditional Chinese medicine preparation |
| CN107349383B (en) * | 2017-06-21 | 2020-10-13 | 广州诺晶生物技术有限公司 | Traditional Chinese medicine preparation for treating ovarian cancer and preparation method thereof |
| CN114146140A (en) * | 2020-09-08 | 2022-03-08 | 陈涵 | Medicine formula for treating leukemia |
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| CN1631388A (en) * | 2003-12-23 | 2005-06-29 | 王绍金 | Chinese traditional medicine for treating chronic prostatitis |
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