CN105727127A - Traditional Chinese medicinal prescription for treating gastric cancer and preparation method of traditional Chinese medicinal prescription - Google Patents
Traditional Chinese medicinal prescription for treating gastric cancer and preparation method of traditional Chinese medicinal prescription Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicinal prescription for treating gastric cancer and a preparation method of the traditional Chinese medicinal prescription. The traditional Chinese medicinal prescription is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 5-15 parts of radix codonopsis, 5-15 parts of stir-fried rhizoma atractylodis macrocephalae, 3-5 parts of fiveleaf akebia fruits, 3-5 parts of radix actinidiae chinensis, 3-5 parts of herba scutellariae barbatae, 2-3 parts of fructus camptothecae acuminatae, 2-3 parts of pseudobulbus cremastrae seu pleiones, 2-3 parts of smilacis chinae rhizoma, 5-10 parts of spreading hedyotis herb, 5-10 parts of herba agrimoniae, 10-15 parts of hull of water chestnut, 5-15 parts of radix angelicae sinensis, 10-20 parts of raw radix astragali, 3-5 parts of pepper, 3-5 parts of fructus amomi, 3-5 parts of dried orange peel and 3-5 parts of liquorice roots. The preparation method comprises a step of decocting the raw materials with water, so that a decoction is obtained. Since the traditional Chinese medicines are effective in nourishing yin and promoting secretion of body fluid, strengthening body resistance, relieving swelling and eliminating stagnation, the traditional Chinese medicinal prescription disclosed by the invention can inhibit tumor propagation, control spread and transfer of the tumor and enhance immunity of patients; and in addition, the traditional Chinese medicinal prescription is capable of relieving pain and eliminating tumor, relieving pain in the patients and saving patients' lives.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly to a kind of Chinese medicine formula treating gastric cancer and preparation method thereof.
Background technology
Gastric cancer ranks first in the various malignant tumor of China.Early gastric cancer majority patient's non-evident sympton, a few peoples have Nausea and vomiting or the digestive symptoms of similar Peptic Ulcers.Pain is with to lose weight be the modal clinical symptoms of advanced gastric carcinoma.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with sb.'s illness took a turn for the worse progress increase the weight of for Upper abdominal pain, appetite decline, weak.The symptoms such as late gastric cancer patient often may occur in which anemia, becomes thin, malnutrition even cachexia.
For the treatment of gastric cancer, current I, II phase gastric cancer, based on surgical radical treatment excision, postoperative II phase gastric cancer is it is contemplated that carry out chemotherapy and treatment by Chinese herbs；III phase gastric cancer is striven for making radical excision, if really can not make radical correction, makes palliative resection；IV phase gastric cancer and without obvious metastasis person, wherein some cases can make radical surgery or palliative resection, it is impossible to excision person make short circuit operation, postoperative employing chemotherapeutic treatment.But all defective property of method of operation and chemotherapeutic treatment, operative treatment is the means of local treatment, like water off a duck's back for the tumor cell transferred in blood or its hetero-organization；Chemotherapy can effectively hinder cancerous cell, but can kill normal cell again simultaneously and cause that the immunologic function of patient is suppressed, and more complication occurs, brings very big damage to patient body.Chinese patent (CN102861193A) discloses a kind of Chinese medicine treating gastric cancer, there is the effect of dispersing swelling and dissipating binds, detoxicating and fighting cancer, but it is effective only for Vitro Tumor experiment and mouse experiment, the therapeutic effect of actual patient is remained to be discussed, treatment cycle does not explain yet, and actual popularization has certain restriction.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine formula treating gastric cancer and preparation method thereof, by the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds effect, it is suppressed that tumor propagation, control tumor diffusion transfer, enhancing immunity, and can pain relieving dispersing tumor, alleviate patient's misery, save patients ' lives.
The present invention provides a kind of Chinese medicine formula treating gastric cancer, formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 5～15 parts, Rhizoma Atractylodis Macrocephalae (parched) 5～15 parts, Fructus Akebiae 3～5 parts, Radix Actinidiae Chinensis 3～5 parts, Herba Scutellariae Barbatae 3～5 parts, Fructus Camptothecae Acuminatae 2～3 parts, Pseudobulbus Cremastrae Seu Pleiones 2～3 parts, Rhizoma Smilacis Chinensis 2～3 parts, Herba Hedyotidis Diffusae 5～10 parts, Herba Agrimoniae 5～10 parts, Shell of Water Chestnut 10～15 parts, Radix Angelicae Sinensis 5～15 parts, Radix Astragali 10～20 parts, 3～5 parts of Fructus Piperis, Fructus Amomi 3～5 parts, Pericarpium Citri Reticulatae 3～5 parts, 3～5 parts of Radix Glycyrrhizae.
It is preferred that be that the raw material of Chinese medicine by following parts by weight is formulated: Radix Codonopsis 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Fructus Akebiae 5 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 4 parts, Fructus Camptothecae Acuminatae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 3 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Hedyotidis Diffusae 6 parts, Herba Agrimoniae 7 parts, Shell of Water Chestnut 12 parts, Radix Angelicae Sinensis 10 parts, Radix Astragali 15 parts, 4 parts of Fructus Piperis, Fructus Amomi 4 parts, Pericarpium Citri Reticulatae 4 parts, 4 parts of Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, adds cold water, did not have medical material 2～5cm, and soaked 1～2 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20～40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Pharmacology analysis:
Radix Codonopsis: property is put down, sweet in the mouth, having effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, have enhancing immunity, expansion blood vessel, blood pressure lowering, improve microcirculation, strengthen the effects such as hemopoietic function, the leukopenia in addition chemotherapy radiotherapy caused has castering action.
Rhizoma Atractylodis Macrocephalae (parched): bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Function invigorating the spleen and benefiting QI, dampness diuretic, strengthening superficial resistance to stop perspiration, antiabortive.Can treating insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, spontaneous sweating due to deficiency of QI, phlegm retention edema, dysuria, and arthralgia chiefly caused by damp pathogen is ached and frequent fetal movement.Modern pharmacological research is reported, the Rhizoma Atractylodis Macrocephalae has hepatic cholagogic, anti-gastric-ulcer, diuresis, raising immunologic function, antitumor, calmness, blood pressure lowering, blood sugar lowering, anticoagulant, resisting pathogenic microbes, the effect such as antiabortive, strong.
Fructus Akebiae: bitter in the mouth, property is put down；Return liver, stomach warp；Function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.Modern pharmacological research is reported, tumor cell is had inhibitory action by it.
Radix Actinidiae Chinensis: function heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, preventing tumor is anticancer, expelling wind and removing dampness, diuresis is stopped blooding, and removing toxic substances and promoting subsidence of swelling cures mainly the diseases such as dyspepsia, vomiting, rheumatic arthralgia, rheumatic ostalgia, Alimentary Tract Cancer, digestive tract tumor, carbuncle and ulcer furuncle, rheumatic ostalgia and jaundice.
Herba Scutellariae Barbatae: pungent, flat；Function heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer；Cure mainly appendicitis, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, gastric cancer, cervical cancer, mastitis etc.；The diseases such as external is controlled pain furuncle and treated, treating swelling and pain by traumatic injury.
Fructus Camptothecae Acuminatae: cold in nature, bitter in the mouth, puckery, poisonous.Function is anticancer, eliminating stagnation, removing blood stasis, for kinds of tumors, such as gastric cancer, intestinal cancer, chorionic epithelioma, lymphosarcoma etc..
Pseudobulbus Cremastrae Seu Pleiones: sweet in the mouth, micro-pungent, cold in nature, mild toxicity；Return liver, stomach, lung meridian.Main furuncle swells, counteracting toxic substances broken skin.Solve all poison, snakeworm, mad dog wound.
Rhizoma Smilacis Chinensis: expelling wind and removing dampness, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, stranguria with turbid discharge, leukorrhagia, have loose bowels, dysentery, carbuncle sore tumefacting virus, stubborn dermatitis, burn and scald；Removing toxic substances, wind dispelling, skin ulcer section key medicine, there is a diaphoresis, wind dispelling, diuresis and control gonorrhea, cancer, the function of diabetes. wherein better with gastric cancer and esophageal carcinoma effect；Leaf is mashed lemma and is controlled malignant boil.
Herba Hedyotidis Diffusae: bitter in the mouth, light, cold in nature；Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness；Cure mainly dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, be good at the multiple cancerous protuberance for the treatment of.
Herba Agrimoniae: property is put down, bitter in the mouth, puckery；Return stomach, liver, spleen, lung, large intestine channel.Function relieves internal heat anticancer, cooling blood for hemostasis, detumescent of healing the wounds, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances；For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.
Shell of Water Chestnut: sweet in the mouth, puckery, cool in nature；Effect invigorating the spleen and replenishing QI spleen invigorating, strong stock knee joint, strong power QI invigorating, cure mainly have loose bowels, proctoptosis, hemorrhoid, treatment are swollen, impetigo, pemphigus.Modern pharmacology proves, Shell of Water Chestnut has the effects such as anti-treatment of esophagus cancer, gastric cancer, cervical cancer, breast carcinoma, can be used as cancer therapy drug.
Radix Angelicae Sinensis: sweet, pungent, warm；There is oxygen lack resistant function；Regulate body's immunity, there is antitumaous effect；Cosmetology effect；Replenishing and activating blood effect；Antibacterial, arteriosclerosis effect.
Radix Astragali: sweet in the mouth, slightly warm in nature, return spleen, lung meridian, enter edema caused by disorder of QI, can rise and can drop.Effect tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, detoxification granulation promoting.Cure mainly internal injury overstrain, spiritlessness and weakness, diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, visceroptosis, failure of the spleen to keep the blood flowing within the vessels hemorrhage, spontaneous perspiration, night sweat etc..Ancient books " book on Chinese herbal medicine warp " is stated: " complement sun, fills space between skin and muscles, control impairment caused by overstrain, longue meat." " book on Chinese herbal medicine converge with speech " say: " tonifying the lung spleen invigorating, defends arresting sweating in fact, fortune of dispeling the wind poison." " in inner feelings ginseng west record medicine " state: " kind diuresis ", " kind control disabled wilted limbs." modern pharmacological research report, the Radix Astragali be significantly improved immunologic function, protection cardiac muscle, protect and improve hemopoietic system, antioxidation, defying age, antitumor, diuresis are protected kidney, are regulated the effect such as blood glucose, nervous system regulation, antibacterial, antiviral and facilitating digestion function.
Fructus Piperis: cure mainly warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, expectorant, removing toxic substances.Control cold-phlegm food stagnation, coldness and pain in the epigastrium, regurgitation, vomit clear water, have loose bowels, cold-dysentery, and solve bromatotoxin.
Fructus Amomi: warm in nature, acrid in the mouth；Enter spleen, stomach warp；Function cures mainly in circulation of qi promoting tune, and stomach function regulating is amusing；Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, gestation fetal movement.
Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature；Return lung, spleen channel；Function regulating qi-flowing for strengthening spleen, in tune, dampness, reduce phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.
Radix Glycyrrhizae: sweet in the mouth, property is put down；Enter spleen, stomach, lung meridian；Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
The Chinese medicine of the present invention, by the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds effect, it is suppressed that tumor propagation, control tumor diffusion transfer, enhancing immunity, and can pain relieving dispersing tumor, alleviate patient's misery, save patients ' lives.
Outcome measure:
Effective: body constitution strengthens, limbs are strong, and abdominal discomfort disappears, and tumor stomach tumor body reduces, and other position has no nascent tumor；
Effective: body constitution strengthens, and tumor stomach has no increase, and other position has no nascent tumor；
Invalid: symptom is unchanged, tumor stomach tumor body increases, or nascent tumor occurs in other position.
Therapeutic outcome: treat 156 patients with gastric cancer, 1 month is a course for the treatment of, 1 day for oral administration 1 dose, take at twice.Use 2 the course for the treatment of present invention Chinese medicine after, effective 145 examples, account for 92.9%, effective 9 examples, account for 5.8%, invalid 2 examples, account for 1.3%.
Attached a few example case is described further:
Case 1: cattle so-and-so, man, 55 years old, because often sense stomach discomfort is had a surplus April, time accompany dull pain to carry out here diagnosis and treatment, patient's appetite significantly reduces, weight loss more than 5 kilograms；Gastroscopy display gastric antrum portion appreciation focus, pathologic finding is shown as gastric antrum portion adenocarcinoma, then gives Chinese medicine of the present invention and treats, effective after 2 courses for the treatment of, and tumor disappearance after half a year follows up a case by regular visits to half a year without recurrence.
Case 2: deep certain, female, 76 years old, cause epigastric discomfort 1 year repeatedly, melena is admitted to hospital January, and weight in patients declines substantially, occurring row black stool before this, rear progress is row's pitch sample loose stool, with tired, weak, the symptom such as absent minded, gastroscopy diagnosis is gastric cancer, then gives medicine of the present invention, effective after using 2 courses for the treatment of, after 3 courses for the treatment of effective, follow up a case by regular visits to 1 year tumor without increasing phenomenon.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine formula treating gastric cancer, formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Fructus Akebiae 5 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 4 parts, Fructus Camptothecae Acuminatae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 3 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Hedyotidis Diffusae 6 parts, Herba Agrimoniae 7 parts, Shell of Water Chestnut 12 parts, Radix Angelicae Sinensis 10 parts, Radix Astragali 15 parts, 4 parts of Fructus Piperis, Fructus Amomi 4 parts, Pericarpium Citri Reticulatae 4 parts, 4 parts of Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, adds cold water, did not have medical material 3cm, and soaked 1.5 hours；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 30min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 2:
A kind of Chinese medicine formula treating gastric cancer, formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 5 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Fructus Akebiae 3 parts, Radix Actinidiae Chinensis 5 parts, Herba Scutellariae Barbatae 3 parts, Fructus Camptothecae Acuminatae 3 parts, Pseudobulbus Cremastrae Seu Pleiones 2 parts, Rhizoma Smilacis Chinensis 3 parts, Herba Hedyotidis Diffusae 5 parts, Herba Agrimoniae 10 parts, Shell of Water Chestnut 10 parts, Radix Angelicae Sinensis 15 parts, Radix Astragali 10 parts, 5 parts of Fructus Piperis, Fructus Amomi 3 parts, Pericarpium Citri Reticulatae 5 parts, 3 parts of Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, adds cold water, did not have medical material 5cm, and soaked 1 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 3:
A kind of Chinese medicine formula treating gastric cancer, formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 5 parts, Fructus Akebiae 5 parts, Radix Actinidiae Chinensis 3 parts, Herba Scutellariae Barbatae 5 parts, Fructus Camptothecae Acuminatae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 3 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Hedyotidis Diffusae 10 parts, Herba Agrimoniae 5 parts, Shell of Water Chestnut 15 parts, Radix Angelicae Sinensis 5 parts, Radix Astragali 20 parts, 3 parts of Fructus Piperis, Fructus Amomi 5 parts, Pericarpium Citri Reticulatae 3 parts, 5 parts of Radix Glycyrrhizae.
Preparation method is that preparation method is made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, adds cold water, did not have medical material 2cm, and soaked 2 hours；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Below the present invention is described in detail, the above, it is only the preferred embodiments of the invention, when the scope of the present invention can not be limited, namely all done impartial change according to the application scope and modify, all should still belong in covering scope of the present invention.
Claims (3)
1. the Chinese medicine formula treating gastric cancer, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 5～15 parts, Rhizoma Atractylodis Macrocephalae (parched) 5～15 parts, Fructus Akebiae 3～5 parts, Radix Actinidiae Chinensis 3～5 parts, Herba Scutellariae Barbatae 3～5 parts, Fructus Camptothecae Acuminatae 2～3 parts, Pseudobulbus Cremastrae Seu Pleiones 2～3 parts, Rhizoma Smilacis Chinensis 2～3 parts, Herba Hedyotidis Diffusae 5～10 parts, Herba Agrimoniae 5～10 parts, Shell of Water Chestnut 10～15 parts, Radix Angelicae Sinensis 5～15 parts, Radix Astragali 10～20 parts, 3～5 parts of Fructus Piperis, Fructus Amomi 3～5 parts, Pericarpium Citri Reticulatae 3～5 parts, 3～5 parts of Radix Glycyrrhizae.
2. the Chinese medicine formula treating gastric cancer as claimed in claim 1, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Fructus Akebiae 5 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 4 parts, Fructus Camptothecae Acuminatae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 3 parts, Rhizoma Smilacis Chinensis 2 parts, Herba Hedyotidis Diffusae 6 parts, Herba Agrimoniae 7 parts, Shell of Water Chestnut 12 parts, Radix Angelicae Sinensis 10 parts, Radix Astragali 15 parts, 4 parts of Fructus Piperis, Fructus Amomi 4 parts, Pericarpium Citri Reticulatae 4 parts, 4 parts of Radix Glycyrrhizae.
3. the method for the preparation Chinese medicine formula treating gastric cancer as claimed in claim 1, it is characterised in that be made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2～5cm, and soaked 1～2 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20～40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
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| CN114558101A (en) * | 2022-04-01 | 2022-05-31 | 河北省中医院(河北中医学院第一附属医院) | Traditional Chinese medicine composition for preventing and treating digestive tract tumor and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114558101A (en) * | 2022-04-01 | 2022-05-31 | 河北省中医院(河北中医学院第一附属医院) | Traditional Chinese medicine composition for preventing and treating digestive tract tumor and preparation method and application thereof |
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