CN105727113A - Chinese and western medicine composition for treating gastric cancer and preparation method of Chinese and western medicine composition - Google Patents
Chinese and western medicine composition for treating gastric cancer and preparation method of Chinese and western medicine composition Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a Chinese and western medicine composition for treating gastric cancer and a preparation method of the Chinese and western medicine composition. A traditional Chinese medicine is prepared from the following raw materials in parts by weight: 2-3 garden balsam seed, 5-10 parts of rhizoma paridis chinensis, 3-5 parts of fructus camptothecae acuminatae, 3-5 parts of radix actinidiae chinensis, 2-3 parts of herba scutellariae barbatae, 2-3 parts of smilacis chinae rhizoma, 5-10 parts of hull of water chestnut, 10-20 parts of raw radix astragali, 3-5 parts of rhizoma galangae and 3-5 parts of liquorice root; and a Western medicine is prepared from the following raw materials in parts by weight: 5-10 parts of capecitabine, 4-6 parts of alpha-mannatide and 4-6 parts of polysaccharopeptide. The Chinese and western medicine composition is in the form of a capsule; on the basis of the effects of the traditional Chinese medicines on nourishing yin and promoting secretion of body fluid, strengthening body resistance, relieving swelling and eliminating stagnation and in combination with the targeting function of the Western medicine, the Chinese and western medicine composition can be directly applied to tumor tissues, so that the medicine is more direct in tumor killing effect and better in safety.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, particularly to a kind of Chinese and western medicinal composition treating gastric cancer and preparation method thereof.
Background technology
Gastric cancer ranks first in the various malignant tumor of China.Early gastric cancer majority patient's non-evident sympton, a few peoples have Nausea and vomiting or the digestive symptoms of similar Peptic Ulcers.Pain is with to lose weight be the modal clinical symptoms of advanced gastric carcinoma.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with sb.'s illness took a turn for the worse progress increase the weight of for Upper abdominal pain, appetite decline, weak.The symptoms such as late gastric cancer patient often may occur in which anemia, becomes thin, malnutrition even cachexia.
For the treatment of gastric cancer, current I, II phase gastric cancer, based on surgical radical treatment excision, postoperative II phase gastric cancer is it is contemplated that carry out chemotherapy and treatment by Chinese herbs;III phase gastric cancer is striven for making radical excision, if really can not make radical correction, makes palliative resection;IV phase gastric cancer and without obvious metastasis person, wherein some cases can make radical surgery or palliative resection, it is impossible to excision person make short circuit operation, postoperative employing chemotherapeutic treatment.But all defective property of method of operation and chemotherapeutic treatment, operative treatment is the means of local treatment, like water off a duck's back for the tumor cell transferred in blood or its hetero-organization;Chemotherapy can effectively hinder cancerous cell, but can kill normal cell again simultaneously and cause that the immunologic function of patient is suppressed, and more complication occurs, brings very big damage to patient body.Chinese patent (CN102861193A) discloses a kind of Chinese medicine treating gastric cancer, there is the effect of dispersing swelling and dissipating binds, detoxicating and fighting cancer, but the therapeutic effect of simple Chinese medicine is unstable, and this patent is effective only for Vitro Tumor experiment and mouse experiment, the therapeutic effect of actual patient is remained to be discussed, treatment cycle does not explain yet, and actual popularization has certain restriction.
Summary of the invention
It is an object of the invention to provide a kind of Chinese and western medicinal composition treating gastric cancer and preparation method thereof, have and prepare easy to use, short treating period and feature evident in efficacy;By the YIN nourishing and the production of body fluid promoting of Chinese medicine, strengthening the body resistance, dispersing swelling and dissipating binds the targeting of effect combined with westem, it is possible to directly act on tumor tissues, make medicine have more direct tumor-killing effect and better safety.
The present invention provides a kind of Chinese and western medicinal composition treating gastric cancer, and wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2~3 parts, Rhizoma Paridis 5~10 parts, Fructus Camptothecae Acuminatae 3~5 parts, Radix Actinidiae Chinensis 3~5 parts, Herba Scutellariae Barbatae 2~3 parts, Rhizoma Smilacis Chinensis 2~3 parts, Shell of Water Chestnut 5~10 parts, Radix Astragali 10~20 parts, Rhizoma Alpiniae Officinarum 3~5 parts, 3~5 parts of Radix Glycyrrhizae;Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5~10 parts, α-mannatide 4~6 parts, polysaccharide-peptide 4~6 parts.
Wherein Chinese medicinal components is it is preferred that for be formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts of Radix Glycyrrhizae.
Wherein western medicine component is it is preferred that for be formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
Preparation method is made up of following steps: 1, weigh raw material of Chinese medicine by above-mentioned parts by weight, cleans, standby after dry, ultraviolet-sterilization;2, weigh Western medicine raw material by above-mentioned parts by weight, wear into fine powder standby;3, adding 5 by the raw material of Chinese medicine weighed up~10 times amount soak by water 1~3 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spray drying, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing;4, add the Western medicine raw material weighed, mixing, load capsule with every 0.3~0.6g dosage, pack.
Pharmacology analysis:
Semen Impatientis: micro-hardship, pungent, temperature, slightly poisonous;Return spleen, Liver Channel.Function relieves internal heat the detumescence of anticancer, scattered silt.Removing blood stasis softening the hard mass, removing food stagnancy.For abdominal mass mass in the abdomen, amenorrhea, dysphagic.Drug sensitive test proves that it is to gastric lymphosarcoma sensitizing cells;Sarcoma-37 there is inhibitory action.
Rhizoma Paridis: hardship is slightly cold mild toxicity, enters Liver Channel.Function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion;Curing mainly digestive tract carcinoma, pulmonary carcinoma, the cerebral tumor and malignant lymphoma, clinic is used for the stagnant malignant lymphoma of pyretic toxicity harmony, pulmonary carcinoma, nasopharyngeal carcinoma, the cerebral tumor and digestive system tumor such as gastric cancer, the esophageal carcinoma, hepatocarcinoma etc..
Fructus Camptothecae Acuminatae: cold in nature, bitter in the mouth, puckery, poisonous.Function is anticancer, eliminating stagnation, removing blood stasis, for kinds of tumors, such as gastric cancer, intestinal cancer, chorionic epithelioma, lymphosarcoma etc..
Radix Actinidiae Chinensis: function heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, preventing tumor is anticancer, expelling wind and removing dampness, diuresis is stopped blooding, and removing toxic substances and promoting subsidence of swelling cures mainly the diseases such as dyspepsia, vomiting, rheumatic arthralgia, rheumatic ostalgia, Alimentary Tract Cancer, digestive tract tumor, carbuncle and ulcer furuncle, rheumatic ostalgia and jaundice.
Herba Scutellariae Barbatae: pungent, flat;Function heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer;Cure mainly appendicitis, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, gastric cancer, cervical cancer, mastitis etc.;The diseases such as external is controlled pain furuncle and treated, treating swelling and pain by traumatic injury.
Rhizoma Smilacis Chinensis: expelling wind and removing dampness, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, stranguria with turbid discharge, leukorrhagia, have loose bowels, dysentery, carbuncle sore tumefacting virus, stubborn dermatitis, burn and scald;Removing toxic substances, wind dispelling, skin ulcer section key medicine, there is a diaphoresis, wind dispelling, diuresis and control gonorrhea, cancer, the function of diabetes. wherein better with gastric cancer and esophageal carcinoma effect;Leaf is mashed lemma and is controlled malignant boil.
Shell of Water Chestnut: sweet in the mouth, puckery, cool in nature;Effect invigorating the spleen and replenishing QI spleen invigorating, strong stock knee joint, strong power QI invigorating, cure mainly have loose bowels, proctoptosis, hemorrhoid, treatment are swollen, impetigo, pemphigus.Modern pharmacology proves, Shell of Water Chestnut has the effects such as anti-treatment of esophagus cancer, gastric cancer, cervical cancer, breast carcinoma, can be used as cancer therapy drug.
Radix Astragali: sweet in the mouth, slightly warm in nature, return spleen, lung meridian, enter edema caused by disorder of QI, can rise and can drop.Effect tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, detoxification granulation promoting.Cure mainly internal injury overstrain, spiritlessness and weakness, diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, visceroptosis, failure of the spleen to keep the blood flowing within the vessels hemorrhage, spontaneous perspiration, night sweat etc..Ancient books " book on Chinese herbal medicine warp " is stated: " complement sun, fills space between skin and muscles, control impairment caused by overstrain, longue meat." " book on Chinese herbal medicine converge with speech " say: " tonifying the lung spleen invigorating, defends arresting sweating in fact, fortune of dispeling the wind poison." " in inner feelings ginseng west record medicine " state: " kind diuresis ", " kind control disabled wilted limbs." modern pharmacological research report, the Radix Astragali be significantly improved immunologic function, protection cardiac muscle, protect and improve hemopoietic system, antioxidation, defying age, antitumor, diuresis are protected kidney, are regulated the effect such as blood glucose, nervous system regulation, antibacterial, antiviral and facilitating digestion function.
Rhizoma Alpiniae Officinarum: nature and flavor temperature pungent, big, nontoxic.Returning spleen, stomach warp, function warming stomach for dispelling cold, help digestion pain relieving, cures mainly coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Radix Glycyrrhizae: sweet in the mouth, property is put down;Enter spleen, stomach, lung meridian;Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Capecitabine: be a kind of antimetabolic fluoropyrimidine deoxynucleoside carbamates medicine that can be transformed into 5-FU in vivo, be mainly used in advanced primary or metastatic breast cancer, the treatment of rectal cancer, colon cancer and gastric cancer.
α-mannatide: be the medicine of enhancing immunity, for the auxiliary treatment of immunologic hypofunction, recurrent respiratory tract infection, leukopenia and aplastic anemia and tumor, alleviates the Radiotherapy chemotherapy side effect to hemopoietic system.
Polysaccharide-peptide: the macromolecule glycopeptide polymer extracted in the mycelium of bacterial strain Cov-1, nourishing the essence and strengthening QI, invigorating spleen and nourishing heart.Cellular immune function and hemogram there is certain protective effect.Deficiency of both QI and YIN caused by the esophageal carcinoma, gastric cancer and Patients With Primary Lung Cancer Radiotherapy chemotherapy, deficiency of both the heart and spleen card.
In the present invention, Semen Impatientis, Rhizoma Paridis, Fructus Camptothecae Acuminatae, Radix Actinidiae Chinensis, Herba Scutellariae Barbatae, Rhizoma Smilacis Chinensis, Shell of Water Chestnut are respectively provided with the effect preventing and treating gastric cancer, and Radix Astragali, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae, there is effect of the pain relieving that helps digestion, enhancing immunity and the adjustment property of medicine, enable to the property of medicine of medicine of the present invention with cancer therapy drug collocation and be more suitable for the treatment of gastric cancer;And, the basis of Chinese medicinal components is added capecitabine, α-mannatide and polysaccharide-peptide, the targeting of combined with westem, it is possible to directly act on tumor tissues, makes medicine have more direct tumor-killing effect and better safety.
Take Chinese medicine and western medicine composition of medicine of the present invention, one time 2, every day twice, point sooner or later two swallow inferior to use half an hour water after meal, be used in conjunction two weeks, have a rest one week, within three weeks, be a course for the treatment of.Should stopping treatment when continuing deterioration or generation not tolerant toxicity such as the state of an illness, gestation and women breast-feeding their children are cautious use of.
Outcome measure:
Effective: body constitution strengthens, limbs are strong, and abdominal discomfort disappears, and tumor stomach tumor body reduces, and other position has no nascent tumor;
Effective: body constitution strengthens, and tumor stomach has no increase, and other position has no nascent tumor;
Invalid: symptom is unchanged, tumor stomach tumor body increases, or nascent tumor occurs in other position.
Therapeutic outcome: treat 158 patients with gastric cancer, use 2 the course for the treatment of present invention medicine after, effective 146 examples, account for 92.4%, effective 11 examples, account for 7.0%, invalid 1 example, account for 0.6%.
Attached a few example case is described further:
Case 1: week certain, man, 69 years old, come institute and check pathological examination display pacing stomach specimen: the long 15CM of greater gastric curvature, little curved 8cm, lesser curvature side is shown in ulcer swollen body thing 4.5*3cm, around mucosa wall protuberance, and the end is coarse, omentum majus 12.5 × 12 × 1.5cm, inside sees enlarged lymph node.Light microscopic finding: cancerous tissue is glandular tube shape, mesh-like growth, and in irregular shape, cell atypia is obvious, and core contaminates greatly deeply, it is seen that kernel, and organization table meets personally non-viable non-apoptotic cell, cancerous tissue infiltrative growth is to coat of the stomach holostrome.Pathological diagnosis: breaking up adenocarcinoma in gastric ulcer type, cancerous tissue invades coat of the stomach holostrome, then gives medicine of the present invention and treats, effective after using 2 courses for the treatment of, effective after 3 courses for the treatment of, follow up a case by regular visits to 1 year tumor without increasing phenomenon.
Case 2: Xue so-and-so, female, 70 years old, because occurring that acid regurgitation is heartburn without obvious inducement, after feed substantially, disease Progressive symmetric erythrokeratodermia increased the weight of to come here and seeks medical advice.Gastroscopy lesser curvature side visible 3cm size similar round ulcer, the end, puts down, and upper attached dirty tongue, periphery mucosa owes smooth;Pathology is shown as adenocarcinoma, then gives medicine of the present invention, effective after 2 courses for the treatment of, and tumor disappearance after half a year follows up a case by regular visits to half a year without recurrence.
Detailed description of the invention
Embodiment described below, is only the preferred embodiments of the invention, when not limiting the scope of the present invention, namely all done impartial change according to the application scope and modifies, all should still belong in covering scope of the present invention.
Embodiment 1:
A kind of Chinese and western medicinal composition treating gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts of Radix Glycyrrhizae;Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
Preparation method is made up of following steps: 1, weigh raw material of Chinese medicine by above-mentioned parts by weight, cleans, standby after dry, ultraviolet-sterilization;2, weigh Western medicine raw material by above-mentioned parts by weight, wear into fine powder standby;3, the raw material of Chinese medicine weighed up being added 6 times amount soak by water 2 hours, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spray drying, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing;4, add the Western medicine raw material weighed, mixing, load capsule with every 0.5g dosage, pack.
Embodiment 2:
A kind of Chinese and western medicinal composition treating gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 10 parts, Fructus Camptothecae Acuminatae 3 parts, Radix Actinidiae Chinensis 5 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 3 parts, Shell of Water Chestnut 5 parts, Radix Astragali 20 parts, Rhizoma Alpiniae Officinarum 3 parts, 5 parts of Radix Glycyrrhizae;Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5 parts, α-mannatide 6 parts, polysaccharide-peptide 4 parts.
Preparation method is made up of following steps: 1, weigh raw material of Chinese medicine by above-mentioned parts by weight, cleans, standby after dry, ultraviolet-sterilization;2, weigh Western medicine raw material by above-mentioned parts by weight, wear into fine powder standby;3, the raw material of Chinese medicine weighed up being added 10 times amount soak by water 1 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spray drying, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing;4, add the Western medicine raw material weighed, mixing, load capsule with every 0.6g dosage, pack.
Embodiment 3:
A kind of Chinese and western medicinal composition treating gastric cancer, wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 3 parts, Rhizoma Paridis 5 parts, Fructus Camptothecae Acuminatae 5 parts, Radix Actinidiae Chinensis 3 parts, Herba Scutellariae Barbatae 3 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 10 parts, Radix Astragali 10 parts, Rhizoma Alpiniae Officinarum 5 parts, 3 parts of Radix Glycyrrhizae;Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 10 parts, α-mannatide 4 parts, polysaccharide-peptide 6 parts.
Preparation method is made up of following steps: 1, weigh raw material of Chinese medicine by above-mentioned parts by weight, cleans, standby after dry, ultraviolet-sterilization;2, weigh Western medicine raw material by above-mentioned parts by weight, wear into fine powder standby;3, the raw material of Chinese medicine weighed up being added 5 times amount soak by water 3 hours, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spray drying, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing;4, add the Western medicine raw material weighed, mixing, load capsule with every 0.3g dosage, pack.
Claims (4)
1. the Chinese and western medicinal composition treating gastric cancer, it is characterised in that wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2~3 parts, Rhizoma Paridis 5~10 parts, Fructus Camptothecae Acuminatae 3~5 parts, Radix Actinidiae Chinensis 3~5 parts, Herba Scutellariae Barbatae 2~3 parts, Rhizoma Smilacis Chinensis 2~3 parts, Shell of Water Chestnut 5~10 parts, Radix Astragali 10~20 parts, Rhizoma Alpiniae Officinarum 3~5 parts, 3~5 parts of Radix Glycyrrhizae;Wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 5~10 parts, α-mannatide 4~6 parts, polysaccharide-peptide 4~6 parts.
2. the Chinese and western medicinal composition treating gastric cancer as claimed in claim 1, it is characterised in that wherein Chinese medicinal components is formed by the preparation of raw material of following parts by weight: Semen Impatientis 2 parts, Rhizoma Paridis 6 parts, Fructus Camptothecae Acuminatae 4 parts, Radix Actinidiae Chinensis 4 parts, Herba Scutellariae Barbatae 2 parts, Rhizoma Smilacis Chinensis 2 parts, Shell of Water Chestnut 7 parts, Radix Astragali 15 parts, Rhizoma Alpiniae Officinarum 4 parts, 4 parts of Radix Glycyrrhizae.
3. the Chinese and western medicinal composition treating gastric cancer as claimed in claim 1 or 2, it is characterised in that wherein western medicine component is formed by the preparation of raw material of following parts by weight: capecitabine 8 parts, α-mannatide 5 parts, polysaccharide-peptide 5 parts.
4. the method for the as claimed in claim 1 Chinese and western medicinal composition treating gastric cancer of preparation, it is characterised in that be made up of following steps: 1, weigh raw material of Chinese medicine by above-mentioned parts by weight, cleans, standby after dry, ultraviolet-sterilization;2, weigh Western medicine raw material by above-mentioned parts by weight, wear into fine powder standby;3, adding 5 by the raw material of Chinese medicine weighed up~10 times amount soak by water 1~3 hour, extracting solution sucking filtration, filtrate is condensed into clear paste, adds appropriate dextrin and stirs evenly, spray drying, and after dry powder adds the mixing of appropriate dextrin, granule is made in dry-pressing;4, add the Western medicine raw material weighed, mixing, load capsule with every 0.3~0.6g dosage, pack.
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