CN107854685A - A kind of Chinese medicine composition with antitumor action and its production and use - Google Patents
A kind of Chinese medicine composition with antitumor action and its production and use Download PDFInfo
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- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of Chinese medicine composition with antitumor action and preparation method thereof, the Chinese medicine composition with antitumor action is made up of the raw material below according to parts by weight：Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, Sweet Broomwort Herb, sky dragon small peptide, curcuma zedoary, oldenlandia diffusa, hairyvein agrimony, asafoetide, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus.Each bulk drug synergy plays in the present invention simply acts on rapid-action, curative for effect, safe and medication, theoretical using diagnosis and treatment carries out Chinese prescription screening, the Chinese medicine composition proportioning of offer is scientific and reasonable, test result indicates that, Chinese medicine composition provided by the invention has the function that to suppress growth of tumour cell well and can promote apoptosis of tumor cells, and strong killing action is respectively provided with to kinds of tumor cells, have wide range of applications, there is no toxic side effect, a new selection is provided for various symptoms caused by clinical pre- alleviation epilepsy.
Description
Technical field
The present invention relates to medical applications technical field, specifically a kind of Chinese medicine composition and its system with antitumor action
Preparation Method and purposes.
Background technology
Tumour turns into serious threat human life and health and wide disease, and the whole world has every year newly to be sent out pernicious and swell
The people of knurl 9,000,000.There are 1,300,000,000 populations in China, every year about 1,600,000 de novo malignancy patients, and about 1,300,000 people are dead every year
Turn into the problem paid attention to extensively in world wide in the preventing and treating of cancer, therefore tumour, countries in the world have put into a large amount of people every year
Power, material resources are studied, but so far, still not very clear to its cause of disease, pathology, treatment method there is no important breakthrough.
Currently, the treatment of tumour mainly has two kinds for the treatment of methods in China, is exactly western medical treatment and Chinese traditional treatment, and doctor trained in Western medicine is controlled
Treatment mainly has operative treatment, radiotherapy and chemotherapy at present.Modern Western medicine treats various tumours frequently with the method for operative treatment, this
Kind method causes greatly painful and heavier financial burden to patient.For malignant tumour, the general place if finding
In middle and advanced stage, operative treatment is not the best approach, although because having cut off focus for Advanced cancers, operation pair simultaneously
The huge wound of human body also accelerates the transfer of cancer cell, and Post operation typically wants Combined with Radiotherapy or change to control, and this chemicotherapy aligns
Ordinary person's body cell has great lethal effect, greatly reduces the immunocompetence of human body itself.Chemotherapy can be to the tumour of whole body
Cell produces certain treatment control action, but the injury to human normal tissue is to be also apparent, and is really controlled by chemotherapy
More tumour is also what is be difficult to.Treatment of the radiotherapy to some region tumors has more satisfactory effect sometimes, but similarly
It is that treatment curative effect to many tumours is can not to reach the expected purpose really cured.During radiotherapy, to human body
Injury is also tended to it will be evident that and performing the operation, more than 5 years survival rates of patient after radiotherapy and chemotherapeutic treatment or very undesirable
's.
Traditional Chinese medicine is a great treasure-house, and it is the wisdom crystallization that our people combats the disease for a long time, should
Method for modern science is excavated and develops it, is once to have a extensive future and arduous thing in the field for the treatment of malignant tumour
Industry.Traditional Chinese medicine thinks tumour occurrence cause nothing more than two kinds of external cause and internal cause, and external cause is perverse trend, evil poison, hinders QI-blood circulation, leads
Cause qi stagnation hemagglutination, phlegm wet cohesion.Internal cause is then that storage poison, the QI-blood circulation of the vital organs of the human body are not normal and seven feelings stimulate.Why is exopathogen
It is also due to that human body first has internal weakness that can invade pathogenic, because heresy is gathered, its gas must be empty.The Methods of TCM of cancer at present
It is main to be treated including attacking, disappearing, mending the dialectical of three methods, conclusive leading therapeutic action can be played, receives the preferable effect for the treatment of a disease by looking into both its root cause and symptoms
Fruit.
Clearing heat and detoxicating, promoting blood circulation and removing blood stasis, softening and resolving hard mass the method for attacking should be used in Chinese medicine cancer disease process, is directly killed
Cancer cell, suppress the growth of tumour, reach the purpose of " eliminating evil "；Simultaneously also will be using the benefit based on strengthening the spleen and stomach, blood-enrich
Method, the immunity of body is improved, reach the purpose of " righting ".To carrying out operation, radiotherapy and chemotherapy it is various
Kind knurl patient, the Methods of TCM using eliminating pathogen to support vital qi, have notable clinical efficacy.
It is therefore, necessary to research and develop that a kind of compatibility is reasonable, and anti-malignant tumor curative effect is reliable on the basis of prior art,
The low Chinese medicine compound prescription of adverse reaction.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition with antitumor action and its production and use.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：Ligusticum wallichii 20-40 parts, ancestral
Teacher fiber crops 15-25 parts, bark of ash 5-10 parts, dried venom of toads 2-4 parts, Resina Draconis 1-3 parts, radix scrophulariae 3-5 parts, Sweet Broomwort Herb 1-2 parts, sky dragon small peptide 1-
2 parts, curcuma zedoary 5-10 parts, oldenlandia diffusa 30-40 parts, hairyvein agrimony 2-4 parts, asafoetide 2-4 parts, ganoderma lucidum 1-3 parts, dalbergia wood 2-4 parts, thousand
Jin dials 10-15 Fen, le three-coloured amaranth 3-5 parts, Hylocereus undatus 5-10 parts.
As further scheme of the invention：The Chinese medicine composition with antitumor action, by below according to weight
Measure the raw material composition of part：Ligusticum wallichii 25-35 parts, girald daphne bark 18-22 parts, bark of ash 6-9 parts, dried venom of toads 2.5-3.5 parts, Resina Draconis 1.5-
2.5 part, radix scrophulariae 3.5-4.5 parts, Sweet Broomwort Herb 1.2-1.8 parts, sky dragon small peptide 1.2-1.8 parts, curcuma zedoary 6-9 parts, oldenlandia diffusa 32-
38 parts, hairyvein agrimony 2.5-3.5 parts, asafoetide 2.5-3.5 parts, ganoderma lucidum 1.5-2.5 parts, dalbergia wood 2.5-3.5 parts, very heavy group of 11-14 part,
Le three-coloured amaranth 3.5-4.5 parts, Hylocereus undatus 6-9 parts.
As further scheme of the invention：The Chinese medicine composition with antitumor action, by below according to weight
Measure the raw material composition of part：30 parts of Ligusticum wallichii, 20 parts of girald daphne bark, 8 parts of bark of ash, 3 parts of the dried venom of toads, 2 parts of Resina Draconis, 4 parts of radix scrophulariae, Sweet Broomwort Herb
1.5 parts, 1.5 parts of sky dragon small peptide, 8 parts of curcuma zedoary, 35 parts of oldenlandia diffusa, 3 parts of hairyvein agrimony, 3 parts of asafoetide, 2 parts of ganoderma lucidum, 3 parts of dalbergia wood,
It is very heavy to dial 12 34 parts of Fen, le three-coloured amaranths, 8 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 6-10 times to measure water homogenate 10-20min, heating boils 5-30min, lets cool to room temperature, adopt
PH to 2.1 is adjusted with hydrochloric acid, amount of substrate 2-4% pepsin is then added, 2-4h is digested under the conditions of 35-45 DEG C, is then used
Sodium hydroxide solution adjusts pH to 7-10, adds amount of substrate 2-4% trypsase, 2-4h is digested under the conditions of 45-55 DEG C, when
When stir and adjust pH and continue heating after 7-10, enzymolysis and boil 5-15min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into
Per the clear cream of 1ml crude drugs containing 0.05-1g, medicinal material amount 15-25% solid paraffin, heating melting are added, and is stirred, is refrigerated
Overnight, paraffin layer is taken out, filtration, filtrate decompression concentration, dries, obtains sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 30-50
Mesh, it is added to after well mixed in extraction kettle, the water of 500-700 parts is then added into extraction kettle, closing extraction kettle, is heated to
105-125 DEG C, pressure 0.4-0.5MPa, 8-10min is kept, room temperature is naturally cooling to, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 80-100 mesh, boiled with decocting
Secondary, each water consumption is 4-6 times of medicinal material weight and measured, and decocts 3-5h every time, filters, filtrate is condensed into relatively close in 60 DEG C of surveys
Spend the clear cream for 1.25, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into and contain
The medicinal extract of solid weight 67%, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
As the further scheme of the present invention：The formulation of the preparation includes：Tablet, pill, capsule, oral liquid,
Mouth containing agent, granule, electuary, pill, powder, sublimed preparation, supensoid agent, pulvis, injection.
As further scheme of the invention：The Chinese medicine preparation is in medicine of the treatment with antitumor action is prepared
Application.
The pharmacological action of each Chinese medicine material in the present invention：
Ligusticum wallichii：Pungent-warm perfume (or spice) is dry, walks without keeping, and can go scattered, up reachable mountain peak top；Enter blood system, the descending reachable sea of blood again.Promoting blood circulation is dispelled
Stasis of blood effect is extensive, the suitable various illnesss of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as head wind headache, arthralgia pain due to rheumatism.
Girald daphne bark：With dispelling wind and removing obstruction in the meridians, the effect of blood stasis removing analgesic.It is usually used in arthralgia pain due to rheumatism, numb limb, has a headache, stomachache,
Pain in the back, traumatic injury.
Bark of ash：It is pungent, bitter, put down.Return stomach, liver, gallbladder channel, wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For muscle arteries and veins contraction, joint acid
Bitterly, afternoon tidal fever, infantile malnutrition generates heat.
The dried venom of toads：Removing toxic substances, detumescence, cardiac stimulant, analgesic, back furunculosis and all pyogenic infections can be controlled again.
Resina Draconis：It is warm-natured, flat, it is sweet, salty, it is nontoxic, enter blood system, return lung, spleen, kidney three pass through, and there is promoting blood circulation and removing blood stasis, detumescence to stop
The remarkable efficacy such as bitterly, astringing to arrest bleeding, softening and resolving hard mass, myogenic sore, have improve body microcirculation, adjustment body metabolism,
Improve the effect such as body's immunity.
Radix scrophulariae：Sweet, bitter, salty, cold nature has a clearing heat and cooling blood, nourishing Yin and falling fire, the effect of detoxicating and resolving a mass.
Sweet Broomwort Herb：It is clearing heat and detoxicating, inducing diuresis to remove edema.Control cough with lung heat, hot summer weather diarrhea, beriberi edema, polio, eczema,
Hot miliaria, laryngitis, erysipelas.
Sky dragon：The spermatogonium of small white mouse can be made to necrose, disappear, illustrate there is inhibitory action to tumour cell；Utilize
The characteristics of dead cancer cell is easily coloured by Yihong of low concentration, experiment in vitro proves, centipede leech injection is to the red dye of cancer cell
Rate is the positive.
Curcuma zedoary：Promoting qi circulation and relieving pain, product dissipating bind, dissipating blood stasis with potent drugs effect can be controlled.
Oldenlandia diffusa：It is its patent medicine bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.Especially
Kind treatment all kinds inflammation.In clinical practice, if finding, oldenlandia diffusa compatibility is proper, can treat a variety of diseases.
Hairyvein agrimony：Young stem and leaf is edible, not only nutritious, and has very strong anticancer function, bitter, dry.Enter lung,
Liver, the spleen channel.There are astringing to arrest bleeding, anti-inflammatory, stop dysentery, removing toxic substances, desinsection, the function of invigorating vital energy and reinforce the heart.Cure mainly haematemesis, spitting of blood, bleeding from five sense organs or subcutaneous tissue, urine
Blood, functional uterine bleeding, dysentery, gastroenteritis, Trichomonas vaginalis, internal lesion caused by overexertion are powerless, sprain lumbago, and external application controls carbuncle and treats sore.
Asafoetide：It is bitter, pungent, temperature, returns spleen, stomach, for meat stagnation, hemostasis addiction lump in the abdomen, mass in abdomen, abdominal pain due to enterositosis.
Ganoderma lucidum：With invigorating qi for tranquilization, it is relieving cough and asthma, promote longevity the effect of.For dizziness egersis, palpitation, nerve
Weak, consumptive disease cough and asthma.
Dalbergia wood：For good analgestic, knife wound bleeding is controlled again.
Very heavy group：With dispelling wind and eliminating dampness, strengthen muscles and bones, the effect of promoting blood circulation and detoxication, clinic is mainly used in treating rheumatic ostealgia, psoas
Strain, hemiplegia, carbuncle swells, the treatment with inferior disease.
Le three-coloured amaranth：Cooling blood and hemostasis；Eliminating dampness and heat；Removing toxicity for eliminating carbuncles, cure mainly gastrorrhagia；Have blood in stool；Hemorrhoid blood；Cholecystitis；Cholelithiasis；
Dysentery；Diarrhea due to damp-heat；Under band；Difficulty and pain in micturition；Abscess of throat；Eczema；Carbuncle swells；Gum is rotten to the corn；Snake bite.
Hylocereus undatus：Nature and flavor are sweet to be slightly cold, and has abundant nutritive value and medical value, to treatment cerebral arteriovenous malformation, lung knot
Core, bronchitis, the tuberculosis of cervical lymph nodes, parotitis, angiocardiopathy have obvious curative effects, and it has clearing heat and moistening lung, except phlegm and relieving cough, grow
The function of face is taken a tonic or nourishing food to build up one's health, is splendid clear benefit soup stock.
Compared with prior art, the beneficial effects of the invention are as follows：
Each bulk drug synergy plays in the present invention simply acts on rapid-action, curative for effect, safe and medication,
Theoretical using diagnosis and treatment carries out Chinese prescription screening, there is provided Chinese medicine composition proportioning it is scientific and reasonable, test result indicates that,
Chinese medicine composition provided by the invention has the function that to suppress well growth of tumour cell and can promote apoptosis of tumor cells, and
Strong killing action is respectively provided with to kinds of tumor cells, is had wide range of applications, without toxic side effect, is drawn for clinical pre- epilepsy of alleviating
The various symptoms risen provide a new selection.
Embodiment
The technical scheme of this patent is described in more detail with reference to embodiment.
Embodiment 1
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：20 parts of Ligusticum wallichii, girald daphne bark
15 parts, 5 parts of bark of ash, 2 parts of the dried venom of toads, 1 part of Resina Draconis, 3 parts of radix scrophulariae, 1 part of Sweet Broomwort Herb, 1 part of sky dragon small peptide, 5 parts of curcuma zedoary, oldenlandia
30 parts of grass, 2 parts of hairyvein agrimony, 2 parts of asafoetide, 1 part of ganoderma lucidum, 2 parts of dalbergia wood, very heavy dial 10 3 parts of Fen, le three-coloured amaranths, 5 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 6 times of amount water homogenate 10min, heating is boiled 5min, lets cool to room temperature, adjusted using hydrochloric acid
PH to 2.1, the pepsin of amount of substrate 2% is then added, 2h is digested under the conditions of 35 DEG C, is then adjusted using sodium hydroxide solution
PH to 7 is saved, the trypsase of amount of substrate 2% is added, 2h is digested under the conditions of 45 DEG C, constantly stirs and adjusts pH 7, digested
Bi Houji temperature of continuing rising boils 5min, lets cool, and centrifugation, centrifugate is concentrated under reduced pressure into the clear cream of every 1ml crude drugs containing 0.05g, adds medicine
The solid paraffin of material amount 15%, heating melting, and stir, refrigerated overnight, paraffin layer, filtration are taken out, filtrate decompression concentrates,
Dry, obtain sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 30 mesh, mixed
It is added to after closing uniformly in extraction kettle, 500 parts of water is then added into extraction kettle, closing extraction kettle, is heated to 105 DEG C, pressure
Power is 0.4MPa, keeps 8min, is naturally cooling to room temperature, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 80 mesh, boiled with decocting it is secondary,
Each water consumption is 4 times of amounts of medicinal material weight, decocts 3h every time, filters, and it is 1.25 that filtrate, which is condensed into and relative density is surveyed at 60 DEG C,
Clear cream, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into containing solid weight
67% medicinal extract, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
Embodiment 2
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：25 parts of Ligusticum wallichii, girald daphne bark
18 parts, 6 parts of bark of ash, 2.5 parts of the dried venom of toads, 1.5 parts of Resina Draconis, 3.5 parts of radix scrophulariae, 1.2 parts of Sweet Broomwort Herb, 1.2 parts of sky dragon small peptide, curcuma zedoary 6
Part, 32 parts of oldenlandia diffusa, 2.5 parts of hairyvein agrimony, 2.5 parts of asafoetide, 1.5 parts of ganoderma lucidum, 2.5 parts of dalbergia wood, very heavy dial 11 Fen, le three-coloured amaranths
3.5 parts, 6 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 7 times of amount water homogenate 12min, heating is boiled 10min, lets cool to room temperature, adjusted using hydrochloric acid
PH to 2.1, the pepsin of amount of substrate 2.5% is then added, 2.5h is digested under the conditions of 38 DEG C, it is then molten using sodium hydroxide
Liquid adjusts pH to 8, adds the trypsase of amount of substrate 2.5%, 2.5h is digested under the conditions of 48 DEG C, constantly stir and adjust pH and exist
8, continue heating after enzymolysis and boil 8min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into the clear cream of every 1ml crude drugs containing 0.1g,
The solid paraffin of medicinal material amount 18%, heating melting are added, and is stirred, refrigerated overnight, takes out paraffin layer, filtration, filtrate decompression
Concentration, dry, obtain sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 35 mesh, mixed
It is added to after closing uniformly in extraction kettle, 550 parts of water is then added into extraction kettle, closing extraction kettle, is heated to 110 DEG C, pressure
Power is 0.42MPa, keeps 8.5min, is naturally cooling to room temperature, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 85 mesh, boiled with decocting it is secondary,
Each water consumption is 4.5 times of amounts of medicinal material weight, decocts 3.5h every time, filters, and filtrate is condensed into is in 60 DEG C of survey relative densities
1.25 clear cream, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into containing solid
The medicinal extract of weight 67%, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
Embodiment 3
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：30 parts of Ligusticum wallichii, girald daphne bark
20 parts, 8 parts of bark of ash, 3 parts of the dried venom of toads, 2 parts of Resina Draconis, 4 parts of radix scrophulariae, 1.5 parts of Sweet Broomwort Herb, 1.5 parts of sky dragon small peptide, 8 parts of curcuma zedoary, white flower
35 parts of HERBA HEDYOTIS DIFFUSAE, 3 parts of hairyvein agrimony, 3 parts of asafoetide, 2 parts of ganoderma lucidum, 3 parts of dalbergia wood, very heavy dial 12 34 parts of Fen, le three-coloured amaranths, 8 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 8 times of amount water homogenate 15min, heating is boiled 20min, lets cool to room temperature, adjusted using hydrochloric acid
PH to 2.1, the pepsin of amount of substrate 3% is then added, 3h is digested under the conditions of 40 DEG C, is then adjusted using sodium hydroxide solution
PH to 8.5 is saved, the trypsase of amount of substrate 3% is added, 3h is digested under the conditions of 50 DEG C, constantly stirs and adjusts pH 8.5, enzyme
Continue heating after solution and boil 10min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into the clear cream of every 1ml crude drugs containing 2g, adds
The solid paraffin of medicinal material amount 20%, heating melting, and stir, refrigerated overnight, paraffin layer is taken out, filtered, filtrate decompression is dense
Contracting, dry, obtain sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 40 mesh, mixed
It is added to after closing uniformly in extraction kettle, 600 parts of water is then added into extraction kettle, closing extraction kettle, is heated to 115 DEG C, pressure
Power is 0.45MPa, keeps 9min, is naturally cooling to room temperature, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 90 mesh, boiled with decocting it is secondary,
Each water consumption is 5 times of amounts of medicinal material weight, decocts 4h every time, filters, and it is 1.25 that filtrate, which is condensed into and relative density is surveyed at 60 DEG C,
Clear cream, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into containing solid weight
67% medicinal extract, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
Embodiment 4
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：35 parts of Ligusticum wallichii, girald daphne bark
22 parts, 9 parts of bark of ash, 3.5 parts of the dried venom of toads, 2.5 parts of Resina Draconis, 4.5 parts of radix scrophulariae, 1.8 parts of Sweet Broomwort Herb, 1.8 parts of sky dragon small peptide, curcuma zedoary 9
Part, 38 parts of oldenlandia diffusa, 3.5 parts of hairyvein agrimony, 3.5 parts of asafoetide, 2.5 parts of ganoderma lucidum, 3.5 parts of dalbergia wood, very heavy dial 14 Fen, le three-coloured amaranths
4.5 parts, 9 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 9 times of amount water homogenate 18min, heating is boiled 20min, lets cool to room temperature, adjusted using hydrochloric acid
PH to 2.1, the pepsin of amount of substrate 3.5% is then added, 3.5h is digested under the conditions of 42 DEG C, it is then molten using sodium hydroxide
Liquid adjusts pH to 9, adds the trypsase of amount of substrate 3.5%, 3.5h is digested under the conditions of 52 DEG C, constantly stir and adjust pH and exist
9, continue heating after enzymolysis and boil 12min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into the clear cream of every 1ml crude drugs containing 3g,
The solid paraffin of medicinal material amount 22%, heating melting are added, and is stirred, refrigerated overnight, takes out paraffin layer, filtration, filtrate decompression
Concentration, dry, obtain sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 45 mesh, mixed
It is added to after closing uniformly in extraction kettle, 650 parts of water is then added into extraction kettle, closing extraction kettle, is heated to 120 DEG C, pressure
Power is 0.48MPa, keeps 9.5min, is naturally cooling to room temperature, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 95 mesh, boiled with decocting it is secondary,
Each water consumption is 5.5 times of amounts of medicinal material weight, decocts 4.5h every time, filters, and filtrate is condensed into is in 60 DEG C of survey relative densities
1.25 clear cream, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into containing solid
The medicinal extract of weight 67%, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
Embodiment 5
A kind of Chinese medicine composition with antitumor action, is made up of the raw material below according to parts by weight：40 parts of Ligusticum wallichii, girald daphne bark
25 parts, 10 parts of bark of ash, 4 parts of the dried venom of toads, 3 parts of Resina Draconis, 5 parts of radix scrophulariae, 2 parts of Sweet Broomwort Herb, 2 parts of sky dragon small peptide, 10 parts of curcuma zedoary, long-noded pit viper
40 parts of tongue grass, 4 parts of hairyvein agrimony, 4 parts of asafoetide, 3 parts of ganoderma lucidum, 4 parts of dalbergia wood, very heavy dial 15 5 parts of Fen, le three-coloured amaranths, 10 parts of Hylocereus undatus.
The preparation method of the Chinese medicine composition with antitumor action, is comprised the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 10 times of amount water homogenate 20min, heating is boiled 30min, let cool to room temperature, using hydrochloric acid
PH to 2.1 is adjusted, the pepsin of amount of substrate 4% is then added, 4h is digested under the conditions of 45 DEG C, then using sodium hydroxide solution
PH to 10 is adjusted, the trypsase of amount of substrate 4% is added, 4h is digested under the conditions of 55 DEG C, constantly stirs and adjusts pH 10, enzyme
Continue heating after solution and boil 15min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into the clear cream of every 1ml crude drugs containing 1g, adds
The solid paraffin of medicinal material amount 25%, heating melting, and stir, refrigerated overnight, paraffin layer is taken out, filtered, filtrate decompression is dense
Contracting, dry, obtain sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 50 mesh, mixed
It is added to after closing uniformly in extraction kettle, 700 parts of water is then added into extraction kettle, closing extraction kettle, is heated to 125 DEG C, pressure
Power is 0.5MPa, keeps 10min, is naturally cooling to room temperature, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 100 mesh, two are boiled with decocting
Secondary, each water consumption is 6 times of amounts of medicinal material weight, decocts 5h every time, filters, and filtrate is condensed into is in 60 DEG C of survey relative densities
1.25 clear cream, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into containing solid
The medicinal extract of weight 67%, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
Embodiment 6
Clinical test
1st, the standard of case selection：Primary gastric cancer patient of the clinical manifestation through pathology or clinical definite is randomly choosed, in meeting
Syndrome of qi stagnation and blood stasis CM syndrome differentiation criterion is cured, totally 60 people, wherein 30 years old of age minimum, maximum 81, average age 52 years old.Knurl body is maximum
Diameter l0cm, minimum 2cm, average 6.2cm；Most short 1 year of the course of disease, most long 5 years, average course of disease was stomach cancer middle and advanced stage.Wherein
28 people have treatment history.As once applied chemotherapy, must end of chemotherapy more than 1 month and have solid tumor or perform the operation and fail excision person.
2nd, the diagnostic criteria of disease：Be mainly shown as hepatalgia, receive it is poor, weak, become thin, abdomen block, limb adynamia, digestion
Bad, nauseous abdominal distension, anaemia, or have ascites, oedema, yellow subcutaneous ulcer, the visible liver's tumour of CT examination.As above symptom, you can make a definite diagnosis.
3rd, administrated method：The capsule that the oral embodiment of the present invention 3 is prepared, three times a day, four every time, warm water
Take.1 month is 1 course for the treatment of, and 3 courses for the treatment of are checked after terminating.
4th, the criterion of curative effect:
1. cure：Symptom and objective determination positive sign disappear, and Continuous Observation half a year is to 1 year without recidivist；
It is 2. effective：Knurl body is obviously reduced, and other symptoms substantially disappear, and life extends；
It is 3. effective：Symptom makes moderate progress, and cancer stove reduces more than half, and other objective determinations take an evident turn for the better；
It is 4. invalid：Symptom and objective determination are without improvement, or only short-term improvement, and rapid deterioration person.
5th, efficacy result is analyzed:
The clinical study results of Treated with Chinese Decoction stomach cancer 60 provided by the invention are shown in Table 1：
The present invention treatment 60 clinical efficacy results of stomach cancer of table 1
| Cure | It is effective | Effectively | It is invalid | ||
| Case load | 60 | 3 | 25 | 24 | 8 |
| Percentage | 100% | 5% | 41.7% | 40% | 13.3% |
The present invention takes the system clinical experiments have proved that Chinese prescription provided by the invention is 86.66% to the total effective rate of stomach cancer
Agent can be remarkably reinforced the constitution of patient, and appetite is remarkably reinforced, and give protection against cancer the knurl that disappears, and long-term use can suppress and prevent cytopathy, increase
Strong man's body immunity function, and there is no toxic side effect.
Model case：
（1）Zhang, female, life in 1962, Nanjing housewife, in October, 2013 get a cancer of the stomach, and are treated in hospital, check
It is transferred, belly distending pain, do not operate on and perform an operation, using conservative treatment, family members require to take what the embodiment of the present invention 3 was prepared
Tablet, it is daily 3-4 times, totally 20 grams, to take aftersensation in January and obtain that sb.'s illness took a favorable turn, belly distending pain symptom takes a turn for the better, and can arrive outdoor activity, after
It is continuous to take 2 months, it can be taken a walk daily to outside, can do housework work.
（2）What certain, nineteen sixty-eight life, Anhui Suzhou City people, suffer from lung cancer in examination in hospital on May 6th, 2008, right lung pain,
Expiratory dyspnea, is not in hospital due to lacking of capital, takes the oral formulations of the embodiment of the present invention 1, daily 3-4 times, 15 grams, takes one
Month aftersensation obtains that sb.'s illness took a favorable turn, and breathing is smooth, and right lung pain, dyspneic symptom has taken a turn for the better.
（3）Zhu, man, life in 1977, on March 17th, 2001 are unenhanced in second hospital upper abdomen CT.Upper left abdomen is shown：8*
10cm agglomerate shadows, its interior density unevenness, the upper bound and right lobe of liver boundary are unclear, the multiple brief summary nodular low-density of display in right lobe of liver
Stove, peritonaeum structure show brief summary nodular enlarged lymph node.CT is diagnosed：Upper left abdomen occupy-place.Consider lobus sinister liver ca and lobus dexter liver m.
On March 23rd, 2001 liver cancer was diagnosed as in certain provincial hospital.Do chemotherapy and can't stand vomiting 2 times, patient voluntarily leaves hospital.The same year 4
The moon starts to take medicine on the 5th, takes once within every six hours, each 18g, 06 days 3 months check knurl body as low as 7.2*9.6cm of medication.Peritonaeum
Do not show.
（4）Zhao, female, nineteen sixty-five life, on July 22nd, 2013 have a medical check-up and check multiple myomata, maximum 3.2*
5.1cm, in September in 2013 start within 20th medication 4 times a day, each 10g, on March 11st, 2014 check knurl body be obviously reduced to
1.6*2.1。
Each bulk drug synergy plays simple with rapid-action, curative for effect, safe and medication in the present invention
Effect, theoretical using diagnosis and treatment carry out Chinese prescription screening, there is provided Chinese medicine composition match scientific and reasonable, experimental result
Show, Chinese medicine composition provided by the invention has to be suppressed growth of tumour cell and can promote the work of apoptosis of tumor cells well
With, and strong killing action is respectively provided with to kinds of tumor cells, have wide range of applications, without toxic side effect, for clinical pre- alleviation
Various symptoms caused by epilepsy provide a new selection.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, can also be on the premise of this patent objective not be departed from one skilled in the relevant art's possessed knowledge
Various changes can be made.
Claims (6)
1. a kind of Chinese medicine composition with antitumor action, it is characterised in that be made up of the raw material below according to parts by weight：River
Rhizome of chuanxiong 20-40 parts, girald daphne bark 15-25 parts, bark of ash 5-10 parts, dried venom of toads 2-4 parts, Resina Draconis 1-3 parts, radix scrophulariae 3-5 parts, Sweet Broomwort Herb 1-2
Part, sky dragon small peptide 1-2 parts, curcuma zedoary 5-10 parts, oldenlandia diffusa 30-40 parts, hairyvein agrimony 2-4 parts, asafoetide 2-4 parts, ganoderma lucidum 1-3
Part, dalbergia wood 2-4 parts, very heavy group of 10-15 Fen, le three-coloured amaranth 3-5 parts, Hylocereus undatus 5-10 parts.
2. the Chinese medicine composition according to claim 1 with antitumor action, it is characterised in that by below according to weight
The raw material composition of part：Ligusticum wallichii 25-35 parts, girald daphne bark 18-22 parts, bark of ash 6-9 parts, dried venom of toads 2.5-3.5 parts, Resina Draconis 1.5-2.5
Part, radix scrophulariae 3.5-4.5 parts, Sweet Broomwort Herb 1.2-1.8 parts, sky dragon small peptide 1.2-1.8 parts, curcuma zedoary 6-9 parts, oldenlandia diffusa 32-38
Part, hairyvein agrimony 2.5-3.5 parts, asafoetide 2.5-3.5 parts, ganoderma lucidum 1.5-2.5 parts, dalbergia wood 2.5-3.5 parts, very heavy group of 11-14 Fen, le
Three-coloured amaranth 3.5-4.5 parts, Hylocereus undatus 6-9 parts.
3. the Chinese medicine composition according to claim 1 with antitumor action, it is characterised in that by below according to weight
The raw material composition of part：30 parts of Ligusticum wallichii, 20 parts of girald daphne bark, 8 parts of bark of ash, 3 parts of the dried venom of toads, 2 parts of Resina Draconis, 4 parts of radix scrophulariae, Sweet Broomwort Herb 1.5
Part, 1.5 parts of sky dragon small peptide, 8 parts of curcuma zedoary, 35 parts of oldenlandia diffusa, 3 parts of hairyvein agrimony, 3 parts of asafoetide, 2 parts of ganoderma lucidum, 3 parts of dalbergia wood, thousand
Jin dials 12 34 parts of Fen, le three-coloured amaranths, 8 parts of Hylocereus undatus.
4. a kind of preparation method of Chinese medicine composition with antitumor action as described in claim 1-3 is any, its feature
It is, comprises the following steps that：
（1）Each raw material is weighed according to parts by weight；
（2）Sky dragon is taken, it is appropriate to crush, add 6-10 times to measure water homogenate 10-20min, heating boils 5-30min, lets cool to room temperature, adopt
PH to 2.1 is adjusted with hydrochloric acid, amount of substrate 2-4% pepsin is then added, 2-4h is digested under the conditions of 35-45 DEG C, is then used
Sodium hydroxide solution adjusts pH to 7-10, adds amount of substrate 2-4% trypsase, 2-4h is digested under the conditions of 45-55 DEG C, when
When stir and adjust pH and continue heating after 7-10, enzymolysis and boil 5-15min, let cool, centrifuge, centrifugate is concentrated under reduced pressure into
Per the clear cream of 1ml crude drugs containing 0.05-1g, medicinal material amount 15-25% solid paraffin, heating melting are added, and is stirred, is refrigerated
Overnight, paraffin layer is taken out, filtration, filtrate decompression concentration, dries, obtains sky dragon small peptide；
（3）Sweet Broomwort Herb, oldenlandia diffusa, hairyvein agrimony, ganoderma lucidum, dalbergia wood, very heavy Bo, le three-coloured amaranth, Hylocereus undatus are crushed to 30-50
Mesh, it is added to after well mixed in extraction kettle, the water of 500-700 parts is then added into extraction kettle, closing extraction kettle, is heated to
105-125 DEG C, pressure 0.4-0.5MPa, 8-10min is kept, room temperature is naturally cooling to, after centrifugation, obtains extract solution；
（3）Obtained extract solution is condensed into the clear cream that relative densities are 1.25 is surveyed at 60 DEG C, add the ethanol to be containing amount of alcohol to making
60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into the medicinal extract containing solid weight 67%, obtain extractum A；
（4）Ligusticum wallichii, girald daphne bark, bark of ash, the dried venom of toads, Resina Draconis, radix scrophulariae, curcuma zedoary and asafoetide are ground into 80-100 mesh, boiled with decocting
Secondary, each water consumption is 4-6 times of medicinal material weight and measured, and decocts 3-5h every time, filters, filtrate is condensed into relatively close in 60 DEG C of surveys
Spend the clear cream for 1.25, add ethanol to make containing amount of alcohol be 60%, stir evenly, stand, filtration, take filtrate recycling ethanol, be condensed into and contain
The medicinal extract of solid weight 67%, obtain medicinal extract B；
（5）Described extractum A is with described medicinal extract B according to volume ratio 1:1, merge and mix, addition sky dragon small peptide, irradiation sterilization,
Medicine routine carrier is added, according to preparation made of the routine techniques of galenic pharmacy, packed products, is produced.
5. the preparation method of the Chinese medicine composition according to claim 4 with antitumor action, it is characterised in that described
The formulation of preparation includes：It is tablet, pill, capsule, oral liquid, mouth containing agent, granule, electuary, pill, powder, sublimed preparation, mixed
Suspension, pulvis, injection.
A kind of 6. Chinese medicine preparation as described in claim 1-3 is any answering in medicine of the treatment with antitumor action is prepared
With.
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| CN103041312A (en) * | 2013-01-10 | 2013-04-17 | 南京海昌中药集团有限公司 | Traditional Chinese medicine composition with antineoplastic effect and preparation method and application thereof |
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| CN103041312A (en) * | 2013-01-10 | 2013-04-17 | 南京海昌中药集团有限公司 | Traditional Chinese medicine composition with antineoplastic effect and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112755053A (en) * | 2019-11-05 | 2021-05-07 | 湖南许丰现代农业股份有限公司 | Processing technology of traditional Chinese medicine tianlong |
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Application publication date: 20180330 |