CN105214027A - A kind of capsule for the treatment of digestive tract tumor and preparation method thereof - Google Patents
A kind of capsule for the treatment of digestive tract tumor and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of capsule for the treatment of digestive tract tumor, take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 10-30 part, Herba Scutellariae Barbatae 10-30 part, Radix Glycyrrhizae 20-40 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20-40 part, Radix Angelicae Pubescentis 10-30 part, Cordyceps 10-30 part, Scolopendra 3-7 part, Rhizoma Imperatae 8-16 part, Radix Raphani 10-30 part, Rhizoma Zingiberis Recens 5-15 part, Aspongopus 1-3 part, Semen Strychni 10-20 part, Semen Juglandis 20-40 part.A kind of capsule Be very effective for the treatment of digestive tract tumor of the present invention, Most patients is clearly better in medication symptom on the same day, and sense of discomfort disappears to some extent, this medicine can reach only cancer pain effect very soon, effective percentage 98%, if can adhere to using according to using method, can control cancerous cell diffusion substantially.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of capsule and preparation method thereof of digestive tract tumor.
Background technology
Digestive tract tumor is that China is occurred frequently and one of tumor that grade malignancy is high, its onset is hidden, and rapidly, therapeutic effect is not good enough for progress, poor prognosis, the Chinese medicine based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs has been widely used in the operation of digestive tract tumor, chemotherapy, the Comprehensive Treatment such as radiotherapy and intervention.
Modern study shows, the generation of tumor development is multifactor, a multistage complex process, and along with the participation of several genes.Being arranged in RAS oncogene inside cell membrane and being in high level activation state at primary hepatocarcinoma, is the study hotspot of generally acknowledging both at home and abroad.Now prove, it is the tertium quid of numerous extracellular signal pathway, its intracellular signaling order is mainly: in extracellular somatomedin → growth factor receptors (having tyrosine kinase activity) → adaptor protein (albumen containing SH2, SH3 structure is as Grb-2, Shc) → guanine nucleotide releasing factor (GRF, as SOS) → ras albumen → MAPKKK (raf-1) → MAPKK (MEK) → MAPK (ERK) → substrate → core, gene → DNA synthesizes and transcribes.Therebetween, GDP is separately had to play negative regulation effect.In this intracellular signaling process, arbitrary or some producers transcribe exception, all can affect the intracellular signaling of ras mediation, thus affect propagation and the differentiation of cell.This shows, play a part very crucial in the change of the TPK-RAS-MAPK signal transduction pathway generation particularly in tumor in the Metabolism regulation process of various cell.
In recent years, molecular targeted therapy also makes some progress in the treatment of hepatocarcinoma.As aspects such as tyrosine kinase inhibitor, angiogensis inhibitor, monoclonal antibody and gene therapies, but general effect is still undesirable.Molecular targeted therapy also faces many difficulties being difficult to overcome, and as Mutiple Targets dependence and acquired drug-resistance etc., all affects therapeutic effect.Along with the progress of molecular biology, genomics, protein science, how to find and will be still the important directions of research to the hepatocarcinoma gene having more killing tumor cell ability with the efficient special carrier system of structure and security and stability thereof more.
Clinically, the traditional Chinese medical science is particular about " overall conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", and Chinese medicine has certain therapeutic efficiency to treatment digestive tract tumor.In existing patent document, Authorization Notice No. CN101791343B(application number 201010130786.0) Chinese patent disclose a kind of righting removing summer-heat Chinese medicine for the treatment of digestive tract tumor, it is characterized in that: it is made up by following weight proportion of following a few taste crude drug: Rhizoma Imperatae 15-45 part, Fructus Ligustri Lucidi 15-45 part, Spica Prunellae 15-45 part, Herba Hedyotidis Diffusae 15-45 part, Ganoderma 15-45 part, Rhizomadioscoreae 15-45 part.Authorization Notice No. CN203029653U(application number 201220693928.9) the pill Chinese patent medicine that patent discloses a kind of anti-alimentary tract tumor, it is characterized in that: the pill Chinese patent medicine of described anti-alimentary tract tumor is made up of internal layer and skin.2. the pill Chinese patent medicine of a kind of anti-alimentary tract tumor according to claim 1, is characterized in that: the pill Chinese patent medicine of described anti-alimentary tract tumor is spherosome.3. the pill Chinese patent medicine of a kind of anti-alimentary tract tumor according to claim 2, is characterized in that: pill spherosome diameter is 1.9mm.
Now have the medicine of this disease for the treatment of numerous and diverse on the market, but to there is treatment time long because of Western medicine preparation, side effect is large, easily repeatedly, effect is undesirable, more and more abandon by people, so the medicine of real arrival affected area is limited, and curative effect is very micro-.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of capsule for the treatment of digestive tract tumor, this capsule utilizes ten multidigit Chinese herbal medicine to work in coordination, make use of the characteristic of Chinese herbal medicine well simultaneously, anticancer diffusion can be played better, only effect of cancer pain, can treat digestive tract tumor, has no pain, easily acceptance, evident in efficacy, not easily irritated feature; The present invention effectively can not only treat digestive tract tumor, and has good curative effect to leukemia, osteocarcinoma, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost; There is therapeutic effect good, have no side effect, the advantage that treatment cost is low.
Another object of the present invention is just to provide the preparation method of above-mentioned capsule.
Above-mentioned purpose of the present invention is achieved through the following technical solutions: a kind of capsule for the treatment of digestive tract tumor, takes off the primary raw material stating weight proportion and is prepared from: Fructus actinidiae chinensis 10-30 part, Herba Scutellariae Barbatae 10-30 part, Radix Glycyrrhizae 20-40 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20-40 part, Radix Angelicae Pubescentis 10-30 part, Cordyceps 10-30 part, Scolopendra 3-7 part, Rhizoma Imperatae 8-16 part, Radix Raphani 10-30 part, Rhizoma Zingiberis Recens 5-15 part, Aspongopus 1-3 part, Semen Strychni 10-20 part, Semen Juglandis 20-40 part.
Treat a capsule for digestive tract tumor, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 15-25 part, Herba Scutellariae Barbatae 15-25 part, Radix Glycyrrhizae 25-35 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 25-35 part, Radix Angelicae Pubescentis 15-25 part, Cordyceps 15-25 part, Scolopendra 4-6 part, Rhizoma Imperatae 10-14 part, Radix Raphani 15-25 part, Rhizoma Zingiberis Recens 8-13 part, Aspongopus 1.5-2.5 part, Semen Strychni 13-18 part, Semen Juglandis 28-38 part.
Treat a capsule for digestive tract tumor, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 20 parts, Herba Scutellariae Barbatae 20 parts, 30 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 30 parts, Radix Angelicae Pubescentis 20 parts, Cordyceps 20 parts, Scolopendra 5 parts, Rhizoma Imperatae 12 parts, Radix Raphani 20 parts, 10 parts, Rhizoma Zingiberis Recens, Aspongopus 2 parts, Semen Strychni 15 parts, Semen Juglandis 33 parts.
The preparation method of above-mentioned arbitrary described capsule, step is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope and place 1-3 hour, spray Scolopendra and Aspongopus weight 0.2-0.6 yellow wine doubly, place after 20-40 minute, parch is crisp, and grinding to form fine powder, to cross 120-160 mesh sieve stand-by;
(2) Fructus actinidiae chinensis is removed the peel, being cut into small pieces, it is stand-by to be placed in plate, cleaned by Radix Raphani, peeling, cuts into slices, be placed in pressure cooker and boil rear steaming 2-6 minute, taking out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air to mix, being gently depressed into thick liquid with large ferrum spoon, being placed in baking box, bake 120-180 second, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 10-20 minute slowly, and being rolled into smalls, to cross 80-120 mesh sieve stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 30-50 minute, little fire decocts 50-70 minute, and filter, filtrate leaves standstill 40-60 minute, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 20-40 minute, load Capsules and get final product.
Above-mentioned preparation method, step (1) is got Scolopendra and Aspongopus Folium Mori sealed envelope and is placed 1.5-2.5 hour (preferred, get Scolopendra and Aspongopus Folium Mori sealed envelope places 2 hours).
Above-mentioned preparation method, step (1) spray Scolopendra and Aspongopus weight 0.3-0.5 yellow wine doubly, place (preferred, the yellow wine of spray Scolopendra and Aspongopus weight 0.4 times, placed after 30 minutes) after 25-35 minute.
Above-mentioned preparation method, step (2) is placed in pressure cooker boils rear steaming 3-5 minute (preferred, to be placed in pressure cooker and to boil rear steaming 4 minutes).
Above-mentioned preparation method, step (2) is placed in baking box, bake 140-160 second (preferred, to be placed in baking box, bake 150 seconds).
Above-mentioned preparation method, step (3) little fire dries 13-18 minute slowly, is rolled into smalls and crosses 90-110 mesh sieve stand-by (preferred, little fire dries 15 minutes slowly, and being rolled into smalls, to cross 100 mesh sieves stand-by).
Above-mentioned preparation method, step (5) soaks 35-45 minute, and little fire decocts 55-65 minute, filters, and filtrate leaves standstill 45-55 minute (preferred, soak 40 minutes, little fire decocts 60 minutes, filters, and filtrate leaves standstill 50 minutes).
The pharmacological effect of each crude drug is respectively:
Fructus actinidiae chinensis: Fructus actinidiae chinensis is except containing the Organic substances such as actinidine, proteolytic enzyme, tannin pectin and saccharide, and outside the trace element such as calcium, potassium, selenium, zinc, germanium and needed by human body 17 seed amino acid, also containing abundant vitamin C, Fructus Vitis viniferae acid, fructose, citric acid, malic acid, fat.Prophylaxis of cancer, has proved that Fructus actinidiae chinensis contains a kind of mutation composition glutathion, has been conducive to the sudden change suppressing to bring out cancer gene.Brighten, light speckle, except skin sore, poison expelling and astheniz resisting old, the Vitamin C content of average every 500g red heart Fructus actinidiae chinensis is up to 95.7 millis, and Fructus actinidiae chinensis gram, is known as the king of fruit.Vitamin C and vitamin E energy skin beauty, antioxidation, effectively brighten, eliminate freckle and skin sore and strengthen the defying age ability of skin.Defatting beauty, kiwifruit fruit sugar content is low, is one of the abundantest comprehensive fruit of nutrition.People units of heat can obtain best balanced nutrition from Fructus actinidiae chinensis, Fructus Melo, Fructus Caricae, citron fruit.Treating dental ulcer, containing abundant VC and VB trace element in Fructus actinidiae chinensis sarcocarp, has natural drug action to preventing canker sore.Prevent and treat, prevent constipation, prevent and treat colon cancer and arteriosclerosis, red heart Fructus actinidiae chinensis contains more dietary fiber and oligosaccharide, proteolytic enzyme.The unwanted metabolic products that can pile up in purged body fast, prevents and treats, prevents constipation, prevents and treats colon cancer and arteriosclerosis.Prevention of depression, kiwifruit fruit contains inositol, and inositol is a kind of precursor of second messenger system in cell.Prevention of depression is effective.Prevention oculopathy (cataract), more and more many adults suffer from cataract, and Fructus actinidiae chinensis is rich in plant chemical ingredient phylloxanthin, and phylloxanthin can be piled up on the retina of people.Strengthen immunologic function, Fructus actinidiae chinensis is considered to a kind of immune adjuvant, mainly because it contains a large amount of VC and antioxidant.Eliminate nervous tired, containing quite high 5-hydroxy tryptamine (vasoconstrictor) in Fructus actinidiae chinensis, five hydroxytryptamine only has sedation to human body.Keep health, Fructus actinidiae chinensis supplements the electrolyte losses particular importance that human body causes because of physical training under containing a large amount of mineral, particularly hot weather.Treatment inappetence, dyspepsia.
Treat inside and outside, gynaecopathia, can be used for health-care antisenile again, it offers to the natural Drug Storage of the mankind just as one, and Chinese Famous scholar Fei Xiaotong professor once appealed Devoting Major Efforts To Developing Actinidia, for the health-care of people contributes.Angiocardiopathy preventing.
Herba Scutellariae Barbatae: have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.This medicine large usage quantity among the people.
Radix Glycyrrhizae: Radix Glycyrrhizae (formal name used at school: GlycyrrhizauralensisFisch) is called: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25 ~ 100 centimetres, diameter 0.6 ~ 3.5 centimetre.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc., and Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
Hericium erinaceus (Bull. Ex Fr.) Pers.: be the sporophore of hedgehog fungus section Hericium fungus Hericium erinaceus (Bull. Ex Fr.) Pers., Hydnum.Composition: containing Hericium erinaceus (Bull. Ex Fr.) Pers. Ketone A, B, C, D, E, F, G, H in Hericium erinaceus, Hericium erinaceus (Bull. Ex Fr.) Pers. alkali etc.Dry sporophore is containing protein, lipid, fiber and glucosan.Also containing sterols: ergosterol etc.Mycelium culture contains Hericium erinaceus (Bull. Ex Fr.) Pers. pyrone A, B etc.The property of medicine: " national Chinese herbal medicine compilation ": " sweet, flat." function cures mainly: strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Cure mainly body void weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
Radix Angelicae Pubescentis: be the root of the heavy tooth Radix Angelicae Sinensis of Umbelliferae archangel.Composition: containing coumarin kind compound, volatile oil, acetas, angelol, thymol.Pharmacology: play a very important role to cardiovascular system, has the effect of blood pressure lowering, can promote hematoblastic gathering, have good analgesia and antiinflammatory action.There is anti-light quick effect, have significant curative effect to opposing tumor, anti-inflammation is also played a very important role.The property of medicine: bitter, tepor, pungent.Return kidney, urinary bladder channel.Function cures mainly: expelling wind and dampness, dispersing cold for relieving pain.
Cordyceps: Cordyceps has another name called Cordyceps, be the famous and precious tonic herb of China's usual one among the people, its nutritional labeling, higher than Radix Ginseng, can be used as medicine, also edible, is superior delicacies, has very high nutritive value.Cordyceps can the immunity of enhancing body, and nourishing lung and kidney, has obvious inhibitory action to pulmonary carcinoma, hepatocarcinoma etc.Clinically to chronic cough of deficiency lung, asthma, hemoptysis of pulmonary tuberculosis, night sweat, soreness of waist and knee joint of suffering from a deficiency of the kidney, impotence and seminal emission, the red blood cell decreased after neurasthenia and chemotherapy, radiotherapy is all effective in cure.
Scolopendra: Scolopendra is medicinal herbs most in use, warm in nature, acrid in the mouth is poisonous.There is the function of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, apoplexy facial hemiparalysis, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Semen Strychni: seed is extremely malicious, main containing the multiple alkaloid such as strychnine and brucine, for stomachic.Be used as medicine after brewed with seed in Chinese medicine, cold in nature, bitter in the mouth, has activating collaterals and eliminating stagnation, the effect of reducing swelling and alleviating pain.With seed extract on western medicine, do central nervous excitation agent.Hardship, cold.Poisonous.Function cures mainly: excited stomach invigorating, detumescence poison, removing heat from blood.Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.
Aspongopus: have another name called black pocket worm, wind plate worm, for Pentatomiddae Aspongopus belongs to the dry Scorpio of animal Aspongopus.The property of medicine: this product is hexagonal shape flat ellipse, and abdominal part brownish red is to brownish black, and matter is crisp, acrid in the mouth, salty, warm in nature.Composition: fatty, protein and chitin etc.Find according to modern pharmacological research, this medical instrument has antibacterial, anticancer, promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG effect, for incoordination between the liver and stomach, and the lumbago that breast side of body epigastric distending pain and insufficiency of kidney-YANG cause.
Rhizoma Zingiberis Recens: gastroptosis and gastroatonia, gastroatonia and stomach wall musele relax, digestive system is bad, inappetence, often has hiccough (belch), symptom of exerting one's utmost effort.Property is pungent cool, controls skin edema, the row severe edema due to hypofunction of the spleen; The pungent temperature of Rhizoma Zingiberis Recens juice, pungent loose cold syndrome of the stomach strength is strong, is used for vomiting; The pungent temperature of Rhizoma Zingiberis, warming middle-JIAO is instigated cold, and recuperating depleted YANG is promoted blood circulation, and warming the spleen trembles with fear strength greatly, and Rhizoma Zingiberis Preparatum acrid in the mouth hardship does not walk table in walking, and the warm part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is cold; Carbonized Rhizoma Zingiberis (processed) is warm in nature, and relatively homoiothermy divides cold; The bitter temperature of Roast Rhizoma Zingiberis Recens, relatively warming intestines and stomach is cold.Pungent and the loose temperature of Rhizoma Zingiberis Recens, strengthening the spleen stomach, kind warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, dehumidify the painful abdominal mass that disappears, and eliminating phlegm and stopping cough take stopping nausea and vomiting by lowering the adverse flow of QI as length, Tumor suppression.
Semen Juglandis: the strong body of tonify deficiency, provides nutrition: prove through zoopery, containing the mixing-in fat diet of Oleum Juglandis, can make body weight increase, and serum albumin increases, and blood cholesterol levels raises comparatively slow, therefore Semen Juglandis is the tonic product of rare a kind of higher fatty acid property material.Anti-inflammation and sterilization, maintaining skin: Semen Persicae has direct inhibiting bacteria and diminishing inflammation effect.According to clinical report, Semen Juglandis is mashed the Semen Juglandis tar zinc oxide paste made, treatment dermatitis, eczema, effective percentage can reach 100%.The oils and fats that Semen Juglandis is rich in, is conducive to moist skin, keeps human activity.Cancer-resisting: experiment proves, Semen Juglandis effective ingredient has inhibitory action to mice S37 tumor.Semen Juglandis skill to kinds of tumors, as esophageal carcinoma, gastric cancer, nasopharyngeal carcinoma, pulmonary carcinoma, thyroid carcinoma, lymphosarcoma etc. have certain inhibitory action.In addition, Semen Juglandis also has town Semen Juglandis pain to cancer patient, promotes the effect such as leukocyte and the liver protecting.
A kind of capsule for the treatment of digestive tract tumor of the present invention meets the theory of the traditional Chinese medical science about treatment digestive tract tumor, for above-mentioned defect in the Chinese medicine process for the treatment of digestive tract tumor, this product is on the basis of summing up forefathers' experience, go through clinical research for many years, adopt pure natural draft Chinese medicine unique formula and technique to refine to form, this product includes abundant plant biological active component, can directly act on affected part, evident in efficacy, to the inirritative feature of the intestines and stomach.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1:treat a capsule for digestive tract tumor, be prepared from (getting 10g for every part) with the primary raw material of following weight proportion: Fructus actinidiae chinensis 10 parts, Herba Scutellariae Barbatae 10 parts, 20 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 20 parts, Radix Angelicae Pubescentis 10 parts, Cordyceps 10 parts, Scolopendra 3 parts, Rhizoma Imperatae 8 parts, Radix Raphani 10 parts, 5 parts, Rhizoma Zingiberis Recens, Aspongopus 12 parts, Semen Strychni 10 parts, Semen Juglandis 20 parts.
The preparation method of the capsule of above-mentioned treatment digestive tract tumor is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope places 1 hour, the yellow wine of spray Scolopendra and Aspongopus weight 0.2 times, place after 20 minutes, parch is crisp, and grinding to form fine powder, to cross 120 mesh sieves stand-by;
(2) removed the peel by Fructus actinidiae chinensis, being cut into small pieces, it is stand-by to be placed in plate, is cleaned by Radix Raphani, peeling, cut into slices, be placed in pressure cooker and boil rear steaming 2 minutes, take out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air and mix, be gently depressed into thick liquid with large ferrum spoon, be placed in baking box, bake 120 seconds, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 10 minutes slowly, and being rolled into smalls, to cross 80 mesh sieves stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 30 minutes, little fire decocts 50 minutes, filters, and filtrate leaves standstill 40 minutes, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 20 minutes, load Capsules and get final product.
typical case one:liu XX, man, 56 years old, people from Jinan City, Shandong Province, finds after Spring Festival last year that pharynx food stalk is choked, affected feed afterwards, remove provincial hospital's esophagogram, the circular lucent area of esophageal patient's epimere 3 × 1cm, the smooth of the edge is neat, and barium agent is in being diverted through, be diagnosed as the level and smooth tumor of Upper Esophageal,, there is spirit depressing when patient examines, shallow complexion in suggestion expectant treatment, uncomfortable in chest, feed is then choked, and disease belongs to stagnation of QI stasis of blood expectorant and ties mutually, hinders in esophagus, gather and form tumor, the thought that patient commits suicide a little, does not think because obtained this disease and involve household, does not want to spend to see to be out of shape.
Take embodiment 1 gained capsule, treat after seven days, uncomfortable in chestly to alleviate, pharynx food takes a turn for the better, and takes one month continuously, and pharynx thing is unobstructed, muscle power strengthens, and defecation is normal, esophagoscopy after two months, esophagus has no mucosal protrusion, and cardia is normal, the agent of canel barium meal contrast examination display barium normal through, no abnormality seen, after drug withdrawal, diet is normal, healthy, maintenance is visited, and diffusing phenomenon do not appear in cancer cancerous cell.
embodiment 2:treat a capsule for digestive tract tumor, be prepared from (getting 10g for every part) with the primary raw material of following weight proportion: Fructus actinidiae chinensis 30 parts, Herba Scutellariae Barbatae 30 parts, 40 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 40 parts, Radix Angelicae Pubescentis 30 parts, Cordyceps 30 parts, Scolopendra 7 parts, Rhizoma Imperatae 16 parts, Radix Raphani 30 parts, 15 parts, Rhizoma Zingiberis Recens, Aspongopus 24 parts, Semen Strychni 20 parts, Semen Juglandis 40 parts.
The preparation method of the capsule of above-mentioned treatment digestive tract tumor is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope places 3 hours, the yellow wine of spray Scolopendra and Aspongopus weight 0.6 times, place after 40 minutes, parch is crisp, and grinding to form fine powder, to cross 160 mesh sieves stand-by;
(2) removed the peel by Fructus actinidiae chinensis, being cut into small pieces, it is stand-by to be placed in plate, is cleaned by Radix Raphani, peeling, cut into slices, be placed in pressure cooker and boil rear steaming 6 minutes, take out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air and mix, be gently depressed into thick liquid with large ferrum spoon, be placed in baking box, bake 180 seconds, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 20 minutes slowly, and being rolled into smalls, to cross 120 mesh sieves stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 50 minutes, little fire decocts 70 minutes, filters, and filtrate leaves standstill 60 minutes, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 40 minutes, load Capsules and get final product.
embodiment 3:treat a capsule for digestive tract tumor, be prepared from (getting 10g for every part) with the primary raw material of following weight proportion: Fructus actinidiae chinensis 15 parts, Herba Scutellariae Barbatae 15 parts, 25 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 25 parts, Radix Angelicae Pubescentis 15 parts, Cordyceps 15 parts, Scolopendra 4 parts, Rhizoma Imperatae 10 parts, Radix Raphani 15 parts, 8 parts, Rhizoma Zingiberis Recens, Aspongopus 14 parts, Semen Strychni 13 parts, Semen Juglandis 28 parts.
The preparation method of the capsule of above-mentioned treatment digestive tract tumor is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope places 1.5 hours, the yellow wine of spray Scolopendra and Aspongopus weight 0.3 times, place after 25 minutes, parch is crisp, and grinding to form fine powder, to cross 130 mesh sieves stand-by;
(2) removed the peel by Fructus actinidiae chinensis, being cut into small pieces, it is stand-by to be placed in plate, is cleaned by Radix Raphani, peeling, cut into slices, be placed in pressure cooker and boil rear steaming 3 minutes, take out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air and mix, be gently depressed into thick liquid with large ferrum spoon, be placed in baking box, bake 140 seconds, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 13 minutes slowly, and being rolled into smalls, to cross 90 mesh sieves stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 35 minutes, little fire decocts 55 minutes, filters, and filtrate leaves standstill 45 minutes, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 25 minutes, load Capsules and get final product.
embodiment 4:treat a capsule for digestive tract tumor, be prepared from (getting 10g for every part) with the primary raw material of following weight proportion: Fructus actinidiae chinensis 25 parts, Herba Scutellariae Barbatae 25 parts, 35 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 35 parts, Radix Angelicae Pubescentis 25 parts, Cordyceps 25 parts, Scolopendra 6 parts, Rhizoma Imperatae 14 parts, Radix Raphani 25 parts, 13 parts, Rhizoma Zingiberis Recens, Aspongopus 22 parts, Semen Strychni 18 parts, Semen Juglandis 38 parts.
The preparation method of the capsule of above-mentioned treatment digestive tract tumor is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope places 2.5 hours, the yellow wine of spray Scolopendra and Aspongopus weight 0.5 times, place after 35 minutes, parch is crisp, and grinding to form fine powder, to cross 150 mesh sieves stand-by;
(2) removed the peel by Fructus actinidiae chinensis, being cut into small pieces, it is stand-by to be placed in plate, is cleaned by Radix Raphani, peeling, cut into slices, be placed in pressure cooker and boil rear steaming 5 minutes, take out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air and mix, be gently depressed into thick liquid with large ferrum spoon, be placed in baking box, bake 160 seconds, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 18 minutes slowly, and being rolled into smalls, to cross 110 mesh sieves stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 45 minutes, little fire decocts 65 minutes, filters, and filtrate leaves standstill 55 minutes, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 35 minutes, load Capsules and get final product.
typical case two:poplar XX, 60 years old, Jinan, Shandong Province people, be diagnosed as pulmonary carcinoma before 2 years, cervical region and limbs pain, cannot walk, week a few days to one defecates once, shape as sheep stool, anorectal pain unbearably, cough apoplexy due to phlegm band black blood, x-ray fluoroscopy right lung top lump, take thing that hospital writes a prescription not take effect, on the small advertisement of community corridor, find capsule of the present invention unintentionally, just bought 2 boxes and taken.
Take embodiment 1 gained capsule, after taking ten days, free movement of the bowels, can be movable voluntarily, and cough alleviates, and apoplexy due to phlegm is not with blood, and overall pain is cleared up, and take medicine continuously 2 months, after drug withdrawal, daily life is without exception.
embodiment 5:treat a capsule for digestive tract tumor, be prepared from (getting 10g for every part) with the primary raw material of following weight proportion: Fructus actinidiae chinensis 20 parts, Herba Scutellariae Barbatae 20 parts, 30 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 30 parts, Radix Angelicae Pubescentis 20 parts, Cordyceps 20 parts, Scolopendra 5 parts, Rhizoma Imperatae 12 parts, Radix Raphani 20 parts, 10 parts, Rhizoma Zingiberis Recens, Aspongopus 18 parts, Semen Strychni 15 parts, Semen Juglandis 33 parts.
The preparation method of the capsule of above-mentioned treatment digestive tract tumor is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope places 2 hours, the yellow wine of spray Scolopendra and Aspongopus weight 0.4 times, place after 30 minutes, parch is crisp, and grinding to form fine powder, to cross 140 mesh sieves stand-by;
(2) removed the peel by Fructus actinidiae chinensis, being cut into small pieces, it is stand-by to be placed in plate, is cleaned by Radix Raphani, peeling, cut into slices, be placed in pressure cooker and boil rear steaming 4 minutes, take out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air and mix, be gently depressed into thick liquid with large ferrum spoon, be placed in baking box, bake 150 seconds, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 15 minutes slowly, and being rolled into smalls, to cross 100 mesh sieves stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 40 minutes, little fire decocts 60 minutes, filters, and filtrate leaves standstill 50 minutes, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 30 minutes, load Capsules and get final product.
experimental example 1:in order to verify the drug effect of embodiment 5 gained capsule, we have also carried out great many of experiments, have chosen 200 patients from 5 hospitals, wherein, the medicine of embodiment 5 products obtained therefrom and this disease of other treatment is utilized to carry out contrast test, we divide into two groups patient in an experiment: matched group and experimental group, matched group uses the medicine of other treatment digestive tract tumor, and every natural gift are observed for three times and record the situation of patient simultaneously, symptom and the emotion situation such as comprise the degree of pain, whether cancerous cell spreads.
Using method: adopt capsule of the present invention, one day three times, takes half an hour or half an hour ante cibum, warm water delivery service after meal by each 2.
Criterion: effectively: after using capsule of the present invention, malaise symptoms alleviates, and cancerous cell is without diffusion, invalid: after using capsule of the present invention, malaise symptoms is unchanged.
Specific experiment result is as following table:
Table 2:
efficacy analysis:experiment shows to use its raising more than 10% evident in efficacy compared with matched group of the experimental group of this medicine, and cure rate significantly improves, and real to solve patient ailing, and can solve great pain and torment that this disease of digestive tract tumor brings to patient.In sum, a kind of capsule Be very effective for the treatment of digestive tract tumor of the present invention, Most patients is clearly better in medication symptom on the same day, sense of discomfort disappears to some extent, this medicine can reach only cancer pain effect very soon, effective percentage 98%, if can adhere to using according to using method, can control cancerous cell diffusion substantially.
Claims (10)
1. treat a capsule for digestive tract tumor, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 10-30 part, Herba Scutellariae Barbatae 10-30 part, Radix Glycyrrhizae 20-40 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20-40 part, Radix Angelicae Pubescentis 10-30 part, Cordyceps 10-30 part, Scolopendra 3-7 part, Rhizoma Imperatae 8-16 part, Radix Raphani 10-30 part, Rhizoma Zingiberis Recens 5-15 part, Aspongopus 1-3 part, Semen Strychni 10-20 part, Semen Juglandis 20-40 part.
2. the capsule for the treatment of digestive tract tumor according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 15-25 part, Herba Scutellariae Barbatae 15-25 part, Radix Glycyrrhizae 25-35 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 25-35 part, Radix Angelicae Pubescentis 15-25 part, Cordyceps 15-25 part, Scolopendra 4-6 part, Rhizoma Imperatae 10-14 part, Radix Raphani 15-25 part, Rhizoma Zingiberis Recens 8-13 part, Aspongopus 1.5-2.5 part, Semen Strychni 13-18 part, Semen Juglandis 28-38 part.
3. the capsule for the treatment of digestive tract tumor according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Fructus actinidiae chinensis 20 parts, Herba Scutellariae Barbatae 20 parts, 30 parts, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers. 30 parts, Radix Angelicae Pubescentis 20 parts, Cordyceps 20 parts, Scolopendra 5 parts, Rhizoma Imperatae 12 parts, Radix Raphani 20 parts, 10 parts, Rhizoma Zingiberis Recens, Aspongopus 2 parts, Semen Strychni 15 parts, Semen Juglandis 33 parts.
4. the preparation method of the capsule of the treatment digestive tract tumor according to any one of claim 1-3, is characterized in that: step is as follows:
(1) get Scolopendra and Aspongopus Folium Mori sealed envelope and place 1-3 hour, spray Scolopendra and Aspongopus weight 0.2-0.6 yellow wine doubly, place after 20-40 minute, parch is crisp, and grinding to form fine powder, to cross 120-160 mesh sieve stand-by;
(2) Fructus actinidiae chinensis is removed the peel, being cut into small pieces, it is stand-by to be placed in plate, cleaned by Radix Raphani, peeling, cuts into slices, be placed in pressure cooker and boil rear steaming 2-6 minute, taking out the cool Fructus actinidiae chinensis with being placed in plate that dries in the air to mix, being gently depressed into thick liquid with large ferrum spoon, being placed in baking box, bake 120-180 second, dry in the air cool stand-by;
(3) cleaned up by Rhizoma Zingiberis Recens, be cut into filament, be placed on iron plate, little fire dries 10-20 minute slowly, and being rolled into smalls, to cross 80-120 mesh sieve stand-by;
(4) by crisp for Semen Juglandis forging, it is stand-by to grind to form smalls;
(5) be placed in marmite by Herba Scutellariae Barbatae, Radix Glycyrrhizae, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Angelicae Pubescentis, Cordyceps, Rhizoma Imperatae and Semen Strychni, add clear water, soak 30-50 minute, little fire decocts 50-70 minute, and filter, filtrate leaves standstill 40-60 minute, obtains supernatant;
(6) by step (1)-(5) gains mixing, decoct and stir into thick paste, thick paste is dried 20-40 minute, load Capsules and get final product.
5. preparation method according to claim 4, is characterized in that: step (1) is got Scolopendra and Aspongopus Folium Mori sealed envelope and placed 1.5-2.5 hour (preferred, get Scolopendra and Aspongopus Folium Mori sealed envelope places 2 hours).
6. preparation method according to claim 4, is characterized in that: step (1) spray Scolopendra and Aspongopus weight 0.3-0.5 yellow wine doubly, places (preferred, the yellow wine of spray Scolopendra and Aspongopus weight 0.4 times, placed after 30 minutes) after 25-35 minute.
7. preparation method according to claim 4, is characterized in that: step (2) is placed in pressure cooker boils rear steaming 3-5 minute (preferred, to be placed in pressure cooker and to boil rear steaming 4 minutes).
8. preparation method according to claim 4, is characterized in that: step (2) is placed in baking box, bake 140-160 second (preferred, to be placed in baking box, bake 150 seconds).
9. preparation method according to claim 4, is characterized in that: step (3) little fire dries 13-18 minute slowly, is rolled into smalls and crosses 90-110 mesh sieve stand-by (preferred, little fire dries 15 minutes slowly, and being rolled into smalls, to cross 100 mesh sieves stand-by).
10. preparation method according to claim 4, is characterized in that: step (5) soaks 35-45 minute, and little fire decocts 55-65 minute, filter, filtrate leaves standstill 45-55 minute and (preferably, soaks 40 minutes, little fire decocts 60 minutes, filters, and filtrate leaves standstill 50 minutes).
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