CN101524473B

CN101524473B - Worm grass anticancer longevity pellet and preparation method thereof

Info

Publication number: CN101524473B
Application number: CN2009100206662A
Authority: CN
Inventors: 焦成玉; 钱得方
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-04-13
Filing date: 2009-04-13
Publication date: 2011-10-12
Anticipated expiration: 2029-04-13
Also published as: CN101524473A

Abstract

The invention relates to worm grass anticancer longevity pellet and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. The worm grass anticancer longevity pellet is prepared by the following raw material medicaments based on weight part: 1000-800 parts of cordyceps militaris, 600-400 parts of tortoise plastron (through vinegar), 300-100 parts of bunge auriculate root, 300-100 parts of ganoderma Lucidum hyphe, 100-50 parts of antelope horn, 300-10 parts of paris polyphylla, 300-100 parts of radix salviae miltiorrhizae, 300-100 parts of American ginseng, 100-50 parts of saffron, 300-200 parts of sealwort, 5-2 parts of muskiness, 10-2 parts of bezoar, 800-500 parts of peperomia blanda and 300-100 parts of cistanche salsa; and the preparation method comprises the following steps: the raw material medicaments are taken according to part proportions, ground into fine powders and sieved by a 200-mesh sieve; the bezoar and the muskiness added into the drug powders according to the part proportion; honey is boiled for 5 minutes, and then the medicament powders are added into the boiled honey to knead drug dough; the drug dough is sterilized at the high temperature and compressed into 10g pills by a pilling machine, and finally, the pills are molded, sealed and packed into boxes. The traditional Chinese medicine has obvious treatment effect, less toxic side effect, rich medicine source and low cost.

Description

Worm grass anticancer longevity pellet and preparation method thereof

Technical field

The present invention relates to the various cancers of a kind of prophylactic treatment, leukemia, Chinese Traditional Medicines thing, specifically is Worm grass anticancer longevity pellet and preparation method thereof.

Background technology

The cardiovascular and cerebrovascular disease serious harm mankind's is healthy, is now classified as first killer who threatens human health by World Health Organization (WHO), and the whole world had a people to die from cardiovascular and cerebrovascular disease in per 2 seconds.Malignant tumor also is a kind of disease of serious threat human health, add up according to World Health Organization (WHO), the whole world has cancer patient 2,200 ten thousand people now, also increase now with annual 1000 ten thousand patients' quantity, serious morbidity reality, impel us to explore, excavate the theory of Chinese traditional treatment cancer, the traditional Chinese medical science is as one of comprehensive treatment, it is anticancer, press down tumor, cure rate, attenuation synergistic, replace chemicotherapy, anti-recurrence shifts, side effect is little, economical and practical characteristics just more and more obtain the approval of doctor and patient, how to subdue this and torture human malignant tumor, become the big of world medical circle, the important topic that cancer drug has become current medical science and life sciences is done in the research invention.

Leukemia is a malignant tumor of hematopoiesis system, claims " leukemia " again, is one of modal malignant tumor of China.According to investigations, the leukemic sickness rate of China accounts for the 6th in various tumors, Therapeutic Method commonly used is chemotherapy and bone marrow transplantation in the doctor trained in Western medicine now, still can only be in interim remission stage, the chemotherapeutic treatment method is cured the symptoms, not the disease, and the high toxic and side effects of expense is big, major injury the hemopoietic system of human body, immune system, fall at last to losing both a person and money.

Summary of the invention

The object of the present invention is to provide a kind of determined curative effect remarkable, toxic and side effects is little, and medical expense is low, and the effective Chinese patent medicine and preparation method thereof of the various cancers of prophylactic treatment, leukemia, cardiovascular and cerebrovascular disease.

Worm grass anticancer longevity pellet that the present invention relates to and preparation method thereof is manufactured by following process by the crude drug of following weight ratio part and to be formed: Cordyceps militaris (L.) Link. 1000-800, Carapax et Plastrum Testudinis (vinegar system) 600-400, Radix Cynanchi Auriculati 300-100, Ganoderma 300-100, Cornu Saigae Tataricae 100-50, Rhizoma Paridis 300-10, Radix Salviae Miltiorrhizae 300-100, Radix Panacis Quinquefolii 300-100, Stigma Croci 100-50, Rhizoma Polygonati 300-200, Moschus 5-2, Calculus Bovis 10-2, Herba Peperomiae Dindygulensis 800-500, Herba Cistanches 300-100.Get above crude drug and wear into fine powder, cross 200 mesh sieves than part; Above-mentioned Calculus Bovis, Moschus than part weight ground in the medicated powder; After Mel was fried boiling 5 minutes, add medicated powder and stir and the patent medicine dough; Through high temperature sterilize, be pressed into ten grammes per square metre pills by the ball machine, the close enclosure of mold.

Worm grass anticancer longevity pellet of the present invention is made by pure Chinese medicine, and the effect of each composition medicine is in the prescription:

Cordyceps militaris (L.) Link.: Cordyceps militaris (L.) Link. not only has special nutritive value, and obvious medicinal value is arranged.Wherein especially based on cordycepic acid, cordycepin, Cordyceps polysaccharide.Low intracranial pressure can fall in cordycepic acid (mannitol) significantly, promotes the body metabolism, thereby cerebral hemorrhage and cerebral thrombosis disease are eased.Cordycepin is a kind of nucleosides material with antibacterial activity, and the nuclear poly A polymerase is had very strong inhibitory action.In DNA transcript mRNA process, make the mRNA dysmaturity, the growth of anticancer.And hypoglycemic effect arranged.Cordyceps polysaccharide is the branched galactomannan of a kind of height, and it can promote lymphocyte transformation, improves the antibody content and the body's immunological function of serum IgG, the anticancer ability that presses down cancer of enhancing body self.SOD (superoxide dismutase) can eliminate superoxide radical in the body, has defying age, the anticancer effect that presses down cancer.In addition, Cordyceps militaris (L.) Link. also contains abundant selenium (Se), and this trace element is generally acknowledged it is the trace element of needed by human by everybody, a large amount of scientific practice proof selenium growths of anticancer significantly.

Carapax et Plastrum Testudinis: YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Control deficiency of kidney yin, the hectic fever due to YIN-deficiency consumptive fever is spitted blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.

Radix Cynanchi Auriculati: strengthening by means of tonics, nourish blood and enrich blood, crow palpus hair color, convergence vital essence, promoting tissue regeneration and ulcer healing, loosening bowel to relieve constipation.Control the prolonged illness weakness, chronic migratory arthralgia, soreness of the waist and knees, anemia, enterorrhagia, early whitening of beard and hair, the neurasthenia, deficiency of YIN chronic malaria, ulcer does not close up for a long time." Shandong Chinese medicine ": be nourishing, strong, hematonic, and can restrain vital essence, crow must hair color.Control the prolonged illness weakness, anemia, early whitening of beard and hair, chronic migratory arthralgia, soreness of the waist and knees, sexual neurasthenie, hemorrhoid, enterorrhagia, deficiency of YIN chronic malaria, ulcer does not close up for a long time.The effect bright and loosening bowel to relieve constipation is arranged is applicable to old man's constipation.

Ganoderma: cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.In the Compendium of Material Medica Ganoderma has been done further research, it has been included into dish portion.Pointed out their medicinal function: the Ganoderma lucidum seu Japonicum materials for improving vision, tonifying liver gas is pacified smart soul practically.Ganoderma lucidum (Leyss. Ex Fr.) Karst. cures mainly knot in the heart, the beneficial motive, and invigorating middle warmer increases intelligence, does not forget.Rhizoma Polygonati cures mainly trusted subordinate's five pathogenic factors, and strengthening the spleen gas is calmed the nerves.Radix Angelicae Dahuricae cures mainly the contrary last gas of belch, lung benefiting gas, tonneau mouth and nose, strong will, peace soul.But the Fructificatio Amaurodermatis Rudae dredging water passages, kidney tonifying gas, the logical seven apertures.Ganoderma is controlled deafness, and god is protected, beneficial vital essence, hard muscles and bones, good color in sharp joint.More than all sesames have all that clothes of a specified duration are made light of one's life by commiting suicide, old, the effect of prolonging life.Clinical research proves that Ganoderma is treated multiple disease: 1, treat various tumors.2, cardiovascular disease such as treatment thrombosis, coronary heart disease, angina pectoris, hyperlipemia, hypertension.3, treatment leukopenia and aplastic anemia.4, the cancer patient is put, the physical rehabilitation after the chemotherapy has tangible effect, can contract, puts, toxicity time after the chemotherapy etc.

Cornu Saigae Tataricae: clearing away heat and relieving spasm, suppressing the hyperactive liver to relieve the wind syndrome, removing toxic substances and promoting subsidence of swelling.The medical value of Cornu Saigae Tataricae goes out very high, is the rare good medicine of treatment thyromegaly, gastritis, chronic diarrhea, also is the oxytocic specific drug.All on the books in the Four-Volume Medical Code (hiding 812 years " residence is known " Christian eras).Cornu pantholopsis Hodgsoni comes into one's own in traditional medicine for centuries always and utilizes.Listed the different curative effects of cornu pantholopsis Hodgsoni in the ancient Tibet books: it can be treated diarrhoea, can be used for expediting the emergence of, can treating the hypertrophy of ulcer, some body of gland of may command and the disease of kidney and blood.

Rhizoma Paridis: be used as medicine with rhizome, heat-clearing and toxic substances removing, reducing swelling and alleviating pain effect are arranged.Among the peoplely be used for the treatment of innominate toxic swelling and venom more, and mumps, tonsillitis, laryngopharynx swelling and pain, mastitis, traumatic injury etc.Human is also arranged in cancerous protuberance, normal and medicine compatibility application such as Herba Salviae Chinensis, Herba Scutellariae Barbatae, Spica Prunellae.Because curative effect is good, folklore has " Rhizoma Paridis, innominate toxic swelling is tackled all problems at once ", " Rhizoma Paridis; the remote mountains is a my family, carbuncle are as me, and just like hands is picked up and taken ", proverbs such as " Rhizoma Paridis; the remote mountains is a my family, and the man controls furuncle, the woman controls milk flower (acute mastitis) ".

Radix Salviae Miltiorrhizae:, increase myocardial flow to the blood vessel function coronary artery dilating; The expansion peripheral blood vessel, blood flow increases; Cerebral blood flow descends.Antithrombotic forms and improves plasmin activity; Prolong, clotting time; Anticoagulant (it is synthetic to improve the interior cAMP level inhibition of platelet TXA2); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten).Promote the reparation and the treatment of regeneration red sage formulation of tissue: necrotic myocardium is removed fast; Fibroblast differentiation, collagen fiber form more obvious; Granulation forms comparative maturity.Local congestion alleviates, blood circulation improves, and healing time shortens.The inhibition hyperplasia has inhibitory action to the fibroblast of hyperplasia.

Radix Panacis Quinquefolii: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.It is thanks to cloudy to be used for the deficiency of vital energy, interior-heat, and cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst dryness of the mouth and throat." property of medicine is examined ": nourishing YIN is brought down a fever.The processed with Rhizoma Zingiberis Recens QI invigorating is set upright gas." Records of Tradition Chinese and Western Medicine in Combination ": can subsidize edema caused by disorder of QI, and can the tonification blood system.

Stigma Croci: modern study finds that but the Stigma Croci preparation has significantly the cancer anti-cancer ability, and particularly Stigma Croci extract dimethyl crocetin all has stronger inhibitory action to leukemia, ovarian cancer, colon cancer, rhabdomyosarcoma, colon cancer, papillosarcoma, pinacocyte tumor and soft tissue sarcoma etc.Its anticancer mechanism may be to destroy the DNA synthetase series, has promptly destroyed the synthetic vital DNA-protein contact of pair cell DNA media, thereby has suppressed the synthetic of DNA and RNA, reaches the effect that suppresses growth of tumour cell.In addition, crocin class material also suppresses the expression of kinase whose activity of cell protein and proto-oncogene.

Moschus: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Moschus has destruction to the animal cancerous cell that exsomatizes, and the Cellular respiration of animal tumor tissue is had obvious inhibitory action.Cardiovascular and cerebrovascular disease had certain curative effect, Moschus ether extraction 150 μ g/kg or 300 μ g/kg intravenous injections, all can cause blood pressure drops and slight decreased heart rate, but heart artery and vein blood oxygen pressure difference and coronary sinus vein flow there is not obvious influence, heavy dose of effect is more obvious, and can resist the cardioexcitatory effect of isoproterenol.

Calculus Bovis: clear away heart-fire, reduce phlegm, function of gallbladder promoting, relieving convulsion.To cardiovascular effect: Calculus Bovis and Calculus Bovis cultivating all can strengthen frog heart myocardial contraction.With the guinea pig isolated heart test, confirm that also Calculus Bovis has cardiotonic.Stone Ban Shi once reported the acidic materials that extract a kind of tasteless odorless from Calculus Bovis.This material is soluble in water with in the alkali and back, and aqueous solution has apparent cardiotonic when 10-7 concentration; Experimental results show that the effect of Calculus Bovis reinforcement heart contraction.Herba Peperomiae Dindygulensis: clearing heat and moistening lung, invigorating the spleen and replenishing QI.Control carbuncle furuncle, edema, traumatic injury, asthma, tuberculosis." choosing of Yunnan Chinese herbal medicine ": " eliminating stasis and resolving masses, anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma.

Herba Cistanches: kidney-replenishing; Benefiting essence-blood; The intestine moistening road.Cure mainly kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; The lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; The dryness of the intestine constipation.

Worm grass anticancer longevity pellet is made by above-mentioned 14 kinds of Chinese crude drugs, and all medicine compatibilities are reasonable, and treating both the principal and secondary aspects of a disease suits pathogenesis, can obtain comparatively satisfactory therapeutic effects to treating various cancers, leukemia, cardiovascular and cerebrovascular disease.Lead-the composition Cordyceps militaris (L.) Link. to contain cordycepin, 18 seed amino acids, protein, saccharide, alcohols, ucleosides, gland Carnis Arca inflata, uracil, multiple electrodeless element, alkaloids, polypeptide, enzyme, cordycepic acid etc. are close with summer in winter Cordyceps composition, so also be same long-lived medicine, has immunization, can increase phagocytosis and body immunity, participate in organism metabolism.Worm grass anticancer longevity pellet has blood circulation promoting and blood stasis dispelling, falls the effect that blood is coagulated the soup, softened cardiovascular and cerebrovascular vessel, can excellent prevention and diseases such as treatment hypertension, cardiovascular and cerebrovascular vessel bolt, stalk.

The anti-cancer function of Worm grass anticancer longevity pellet is mainly reflected in to set upright amasses wealth by heavy taxation this, and the ability of group certainly of life will make great efforts to adjust, and makes life recover order again.Worm grass anticancer longevity pellet can transform to normal cell by inducing cancer cell, that is to say cancerous cell is turned over a new leaf, and confirms through biological study, displacement has taken place in chromosome in the nucleus of cancerous cell, thereby, cause the malignancy of cancerous cell, and Worm grass anticancer longevity pellet has its repair function.Worm grass anticancer longevity pellet can cancer cell specific induction of apoptosis notion allow cancerous cell by its growth rhythm death exactly.Worm grass anticancer longevity pellet can strengthen human immunity to be regulated, and gets involved in the cancerous cell and makes its apoptosis, can impel the enhancing of immunologic function, phagocytic function, thereby reaches the purpose of curing cancer.Cordyceps militaris (L.) Link. anti-tumor drug activity is 3-5 a times of Cordyceps, can activate phagocyte and produce cell toxicant, directly kill cancer cell.Antagonism cancer mutagenic agent is arranged---methylmethane sulfonic acid fat (mms), the chemical constitution of mms is changed, make it no longer include mutagenicity, make DNA that its anti-mutation effect be arranged.

Treatment by Chinese herbs effect of the present invention is obvious, and toxic side effect is little, and the medicine source is abundant, and is cheap.

Points for attention: the wet person's forbidding of anemia of pregnant woman and cold syndrome of the stomach.

The specific embodiment

Embodiment 1: Worm grass anticancer longevity pellet and preparation method thereof, and manufacture by the crude drug of following weight ratio part and to form: Cordyceps militaris (L.) Link. 900, Carapax et Plastrum Testudinis (vinegar system) 500, Radix Cynanchi Auriculati 200, Ganoderma 200, Cornu Saigae Tataricae 75, Rhizoma Paridis 150, Radix Salviae Miltiorrhizae 200, Radix Panacis Quinquefolii 200, Stigma Croci 75, Rhizoma Polygonati 250, Moschus 3.5, Calculus Bovis 6, Herba Peperomiae Dindygulensis 650, Herba Cistanches 200.Get above crude drug and wear into fine powder, cross 200 mesh sieves than part; Above-mentioned Calculus Bovis, Moschus than part weight ground in the medicated powder; After Mel was fried boiling 5 minutes, add medicated powder and stir and the patent medicine dough; Through high temperature sterilize, be pressed into ten grammes per square metre pills by the ball machine, the close enclosure of mold.

Embodiment 2: Worm grass anticancer longevity pellet and preparation method thereof, and manufacture by following process by the crude drug of following weight ratio part and to form: Cordyceps militaris (L.) Link. 1000, Carapax et Plastrum Testudinis (vinegar system) 600, Radix Cynanchi Auriculati 300, Ganoderma 300, Cornu Saigae Tataricae 100, Rhizoma Paridis 300, Radix Salviae Miltiorrhizae 300, Radix Panacis Quinquefolii 300, Stigma Croci 100, Rhizoma Polygonati 300, Moschus 5, Calculus Bovis 10, Herba Peperomiae Dindygulensis 800, Herba Cistanches 300.Get above crude drug and wear into fine powder, cross 200 mesh sieves than part; Above-mentioned Calculus Bovis, Moschus than part weight ground in the medicated powder; After Mel was fried boiling 5 minutes, add medicated powder and stir and the patent medicine dough; Through high temperature sterilize, be pressed into ten grammes per square metre pills by the ball machine, the close enclosure of mold.

Embodiment 3: Worm grass anticancer longevity pellet and preparation method thereof, and manufacture by following process by the crude drug of following weight ratio part and to form: Cordyceps militaris (L.) Link. 800, Carapax et Plastrum Testudinis (vinegar system) 400, Radix Cynanchi Auriculati 100, Ganoderma 100, Cornu Saigae Tataricae 50, Rhizoma Paridis 10, Radix Salviae Miltiorrhizae 100, Radix Panacis Quinquefolii 100, Stigma Croci 50, Rhizoma Polygonati 200, Moschus 2, Calculus Bovis 2, Herba Peperomiae Dindygulensis 500, Herba Cistanches 100.Get above crude drug and wear into fine powder, cross 200 mesh sieves than part; Above-mentioned Calculus Bovis, Moschus than part weight ground in the medicated powder; After Mel was fried boiling 5 minutes, add medicated powder and stir and the patent medicine dough; Through high temperature sterilize, be pressed into ten grammes per square metre pills by the ball machine, the close enclosure of mold.

Case 1:

Wu Yuege, woman, 62 years old, ancient city, Shenxian County Guo Zhuan people, confirmed as the cervix uteri squamous cell carcinoma in the provincial hospital in 2002, and can not perform the operation, not obvious through radiotherapy, chemotherapy effect, still suffer from abdominal pain, bleed, defecate and also be with blood, shift occupy-place 4cm through the People's Hospital, Shenxian County radiography sigmoid colon again, can't treat.When coming my institute to seek medical advice, stool band blood four months, every day 20-30 time, tenesmus, stomachache are unable to leave the bed unbearably, and the state of an illness is critical.Took Worm grass anticancer longevity pellet one month, the stomachache of having blood in stool is ended, and the sick recovery from illness of in March, 2004 check is taken half a year altogether.It is normal to visit life, alive so far.

Case 2:

Duan Yuzhuo, man, 62 years old, Shandong Province's Liaocheng City cadre of public security bureau.Be CT in the Liaocheng City the People's Hospital in November, 2007, and the right lung door has the 2.6-3.4cm lump, pathological replacement: middle differentiation squamous cell carcinoma.Come my institute's inquiry, insensitive because of the Squamous Cell Carcinoma chemotherapy, advise not chemotherapy, take Worm grass anticancer longevity pellet, to obey altogether 6 months, check lump and disappear in April, 2008, and now living, all are normal.

Case 3:

Hu Changqing, man, 42 years old, Jiang Lou township, Donga, Shandong Province county.In August, 2007, hyperpyrexia was hemorrhage, and the People's Hospital confirms as M4 at Liaocheng City, and chemotherapy once.Brain is white with taking place, and changes chemotherapy regimen chemotherapy again, and patient is agonizing, repeatedly blood transfusion and platelet.The expenses for medicine height can't afford, and comes my institute to seek medical advice, the clothes Worm grass anticancer longevity pellet, and routine blood test is normal after 2 months, and bone marrow is normal after half a year, and often after treatment is taken on a small quantity, makes business as usual now.

Li Guixiang, man, 73 years old, Shenyang City's Tiexi District south ten mid-way No. 24 building retired workers.Patient's hypertension, arteriosclerosis, cardiac blood supply deficiency, uncomfortable in chest, angina pectoris, cerebral thrombosis plug once recover through treatment, but sudden faint are arranged at ordinary times on ground, this world of not waking up.It is dumb to walk, numb limbs and tense tendons, and spirit is dull.Listen others to introduce the Worm grass anticancer longevity pellet good effect, begin then to take, after half a year, above-mentioned symptom completely without, in high spirits, energetic, after obey half a year again, health returns to one's perfect health.

Claims

1. Worm grass anticancer longevity pellet; it is characterized in that, manufacture by the crude drug of following weight ratio part and form: Cordyceps militaris (L.) Link. 1000, vinegar CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 600, Radix Cynanchi Auriculati 300, Ganoderma 300, Cornu Saigae Tataricae 100, Rhizoma Paridis 300, Radix Salviae Miltiorrhizae 300, Radix Panacis Quinquefolii 300, Stigma Croci 100, Rhizoma Polygonati 300, Moschus 5, Calculus Bovis 10, Herba Peperomiae Dindygulensis 800, Herba Cistanches 300.

2. Worm grass anticancer longevity pellet; it is characterized in that, manufacture by the crude drug of following weight ratio part and form: Cordyceps militaris (L.) Link. 800, vinegar CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 400, Radix Cynanchi Auriculati 100, Ganoderma 100, Cornu Saigae Tataricae 50, Rhizoma Paridis 10, Radix Salviae Miltiorrhizae 100, Radix Panacis Quinquefolii 100, Stigma Croci 50, Rhizoma Polygonati 200, Moschus 2, Calculus Bovis 2, Herba Peperomiae Dindygulensis 500, Herba Cistanches 100.

3. Worm grass anticancer longevity pellet; it is characterized in that, manufacture by the crude drug of following weight ratio part and form: Cordyceps militaris (L.) Link. 900, vinegar CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 500, Radix Cynanchi Auriculati 200, Ganoderma 200, Cornu Saigae Tataricae 75, Rhizoma Paridis 150, Radix Salviae Miltiorrhizae 200, Radix Panacis Quinquefolii 200, Stigma Croci 75, Rhizoma Polygonati 250, Moschus 3.5, Calculus Bovis 6, Herba Peperomiae Dindygulensis 650, Herba Cistanches 200.

4. according to claim 1 or 2 or 3 described Worm grass anticancer longevity pellet preparation methoies, it is characterized in that, manufacture by follow procedure and form: get above-mentioned than part crude drug wear into fine powder, cross 200 mesh sieves; Above-mentioned Calculus Bovis, Moschus than part weight ground in the medicated powder; After Mel was fried boiling 5 minutes, add medicated powder and stir and the patent medicine dough; Through high temperature sterilize, be pressed into ten grammes per square metre pills by the ball machine, the close enclosure of mold.