CN105125910A - Traditional Chinese medicinal composition for treating sciatica and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating sciatica and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating sciatica, wherein the traditional Chinese medicinal composition is mainly prepared from the following raw materials in parts by weight: 8-14 parts of frankincense, 10-13 parts of girald pteroxygonum root, 9-15 parts of java lysimachia, 11-15 parts of Chinese desmos leaf, 8-16 parts of waterplantain ottelia herb, 6-12 parts of wilson begonia rhizome, 9-14 parts of common nandina root, 8-13 parts of polygonum japonicum meisn., 7-12 parts of fortune firethorn fruit, 9-13 parts of rhizoma typhonii, 7-14 parts of mountain ash, 8-12 parts of ficus pumila, 10-16 parts of all-grass of south circaea, 8-15 parts of hypericum sampsonii hance, 10-14 parts of unilocular crateva and 9-16 parts of blight wheat. The traditional Chinese medicinal composition disclosed by the invention has functions of dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, eliminating phlegm and freeing channels, relaxing tendons and relieving pain; and the traditional Chinese medicinal composition is free from side effect, and has a good effect on treating sciatica.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of sciatica and preparation method thereof.
Background technology
Sciatica refers to that sciatic nerve is oppressed, the pain symptom group that outside and foot outside occur after sciatic nerve path and waist, buttocks, thigh, after shank.First sciatica patient will note changing lifestyles, and should do reconditioning at ordinary times more; Avoid the footwear that threading is followed in life as far as possible, the reach slightly of center of gravity all can make pain symptom increase the weight of, with good conditionsi select negative with footwear; Should be crouched in daily life hardboard bed, clinostatism of making even, and keeps the stable of spinal column, reduce the pressure that intervertebral disc bears.Sciatic nerve is made up of waist 4 ~ sacrum 2 nerve root.Divide root and dryness sciatica two kinds by lesion, the former is positioned at intraspinal tube at common sciatica of nerve roots pathological changes, and the cause of disease is the most common with prolapse of lumbar intervertebral disc, and next has intraspinal tumor, tuberculosis of spine, lumbosacral radiculitis etc.The pathological changes of dryness sciatica is mainly on the outer sciatic nerve stroke of canalis spinalis, and the cause of disease has the improper and diabetes of the compressing of sacroiliitis, basin intracavitary neoplasm, gravid uterus, buttocks wound, pyriformis syndrome, gluteal muscle etc.Primary disease male person between twenty and fifty are common, and be especially common in the last few years and do office work and use the long crowd of machine time, one-sided be many, pain degree and the time often relevant with the cause of disease and onset emergency.
Primary sciatica, constitutional is the pain that sciatic inflammation causes, in the majority with one-sided person, can often and myofibrositis occur simultaneously.The principal pathogenetic reason of primary sciatica (sciatic neuritis) is that other inflammation foci such as cold wet and tonsillitis, prostatitis, gingivitis, sinusitis infect, the myositis that occurs together the while of some and fibromyositis.Secondary Sciatic Pain causes due to the compressing of adjacent lesion or stimulation, is divided into again root and dryness sciatica, refers to that pressurized position is in nerve root or in nerve trunk respectively.Root is common, and the cause of disease is the most common with intervertebral disk hernia, and other causes of disease have intraspinal tumor, vertebral body transfer disease, tuberculosis of spine, lumbar spinal stenosis etc.; Dryness can caused by sacroiliitis, basin intracavitary neoplasm, gravid uterus compressing, coxitis, buttocks wound, diabetes etc.
The medicine of existing Chinese traditional treatment sciatica also has much, for the problems referred to above, publication number CN103394031A (application number 201310321836.7) patent document discloses a kind of medicine for the treatment of sciatica, is that crude drug prepares by the medicine of following parts by weight: Radix Codonopsis 16-24, Radix Astragali 16-24, Cortex Eucommiae 16-24, Radix Cyathulae 12-18, Radix Curcumae 12-18, Radix Aconiti Kusnezoffii 7-11, Olibanum 8-12, Myrrha 8-12, Scorpio 8-12, Scolopendra 6-10, Herba Lycopodii 8-12, Radix Clematidis 8-12, Herba Siegesbeckiae 8-12, Radix Glycyrrhizae 12-18.Publication number CN104740142A (application number 201310726804.5) patent document discloses a kind of Chinese medicine for the treatment of sciatica, the crude drug making effective ingredient by following weight parts is: Radix Dipsaci 10-30 part, Radix Achyranthis Bidentatae 10-30 part, Radix Paeoniae Alba 10-20 part, Radix Angelicae Sinensis 10-30 part, Radix Rehmanniae Preparata 10-25 part, Rhizoma Corydalis 5-10 part, Radix Angelicae Pubescentis 10-30 part, Flos Carthami 10-30 part, Cortex Eucommiae 10-30 part, Rhizoma Atractylodis 20-30 part, Radix Aconiti 10-30 part, Myrrha 15-30 part, Radix Clematidis 20-50 part, Rhizoma Homalomenae 10-30 part, Caulis Spatholobi 10-30 part, Radix Glycyrrhizae 5-30 part, Rhizoma Chuanxiong 10-20 part, Ramulus Cinnamomi 5-20 part, Semen Persicae 15-30 part, Radix Stephaniae Tetrandrae 20-50 part.Publication number CN104288698A(application number 201410580550.5) patent document discloses a kind of Chinese medicine for the treatment of sciatica, it is be made up of the raw material of following weight proportion: Radix Pedicularis Henryi 10-30 part, Ramulus Cinnamomi 10-30 part, Rhizoma Curcumae 5-20 part, Rhizoma Chuanxiong 5-20 part, Rhizoma Polygoni Cuspidati 5-15 part, Radix Rubiae 5-20 part, Radix Bupleuri 5-20 part, Myrrha 5-15 part, Fructus Gardeniae 5-15 part, Radix Cyathulae 5-15 part, Celastrus orbiculatus Thunb. 5-12 part, Radix Nandinae Domesticae 5-20 part, Herba Abri 5-15 part, white Radix Angelicae Pubescentis 5-15 part, Rhizoma anemones davidii 5-15 part, Herba Pyrolae 5-15 part, Radix Gentianae Macrophyllae 5-15 part, Fructus Corni 5-15 part.
At present, treatment sciatica mainly contains Drug therapy and operative treatment, there is very large risk in operative treatment, easily cause the situations such as paralysis, and Drug therapy is cured the symptoms, not the disease more, although adopt analgesic can alleviating pain to a certain extent, but can not cure, side effect is large, and life-time service can produce untoward reaction, cause hepatorenal damage, toxic and side effects is large.Existing Chinese medicine also has many, but most effect is undesirable.
Summary of the invention
For the deficiency of existing treatment sciatica, an object of the present invention is the Chinese medicine composition providing treatment sciatica, have effect of expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, clearing away phlegm dredging collateral, muscles and tendons relaxing to alleviate pain, have no side effect, treatment sciatica is effective.Another object is just to provide the preparation method of the Chinese medicine composition of above-mentioned treatment sciatica.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine composition for the treatment of sciatica, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 8-14 part; Radix Pteroxygoni Giraldii 10-13 part; The careless 9-15 part of scrofula; Folium desmoris 11-15 part; Herba Otteliae Alismoidis 8-16 part; Rhizoma Begoniae Willsonii 6-12 part; Radix Nandinae Domesticae 9-14 part; Herba Polygoni japonici 8-13 part; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 7-12 part; Rhizoma Typhonii 9-13 part; Fructus Sorbi Pohuashanensis 7-14 part; Caulis fici pumilae (Fructus Fici Pumilae) 8-12 part; Herba Circaeae mollis 10-16 part; Herba Hyperici Sampsonii 8-15 part; Tree head dish 10-14 part; Fructus Tritici Levis 9-16 part.
The Chinese medicine composition for the treatment of sciatica, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 10-12 part; Radix Pteroxygoni Giraldii 11-12 part; The careless 11-13 part of scrofula; Folium desmoris 12-14 part; Herba Otteliae Alismoidis 11-13 part; Rhizoma Begoniae Willsonii 8-10 part; Radix Nandinae Domesticae 11-13 part; Herba Polygoni japonici 10-12 part; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9-11 part; Rhizoma Typhonii 10-12 part; Fructus Sorbi Pohuashanensis 10-12 part; Caulis fici pumilae (Fructus Fici Pumilae) 9-11 part; Herba Circaeae mollis 12-14 part; Herba Hyperici Sampsonii 11-13 part; Tree head dish 11-13 part; Fructus Tritici Levis 12-14 part.
The Chinese medicine composition for the treatment of sciatica, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 11 parts; Radix Pteroxygoni Giraldii 11.5 parts; Scrofula grass 12 parts; Folium desmoris 13 parts; Herba Otteliae Alismoidis 12 parts; Rhizoma Begoniae Willsonii 9 parts; Radix Nandinae Domesticae 12 parts; Herba Polygoni japonici 11 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 10 parts; Rhizoma Typhonii 11 parts; Fructus Sorbi Pohuashanensis 11 parts; Caulis fici pumilae (Fructus Fici Pumilae) 10 parts; Herba Circaeae mollis 13 parts; Herba Hyperici Sampsonii 12 parts; Tree head dish 12 parts; Fructus Tritici Levis 13 parts.
Present invention also offers the preparation method Chinese medicine composition of above-mentioned treatment sciatica being made pharmaceutically acceptable oral liquid, granule, capsule, tablet and pill.
The preparation method of the Chinese medicine composition oral liquid of described treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis, boil rear continuation and decoct 30-40 minute (preferably continue to decoct 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, (consumption of preferred xylitol is the 7%-9% of filtrate 2 quality to add xylitol, the consumption being more preferably xylitol is 8% of filtrate 2 quality), mix homogeneously, high temperature sterilization 30-40 minute (preferred high temperature sterilization 33-37 minute, be more preferably high temperature sterilization 35 minutes), sterile packaged.
According to preparation method recited above, preferred scheme is: the consumption of the preferred Rhizoma Zingiberis of step (1) is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality.
Instructions of taking: each 10-15ml, every day 3 times, 4 days courses for the treatment of.
The preparation method of the Chinese medicinal composition granules of described treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol, floods 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), mix homogeneously, makes uniform fine particle, with the specification sterile packaged of every parcel 6g.
According to preparation method recited above, preferred scheme is: the consumption of step (3) preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass, and the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 4 days courses for the treatment of.
The preparation method of the Chinese medicinal composition capsules of described treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), dry, pulverize, obtain medicated powder, make capsule by the specification of 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain).
Using method: each 1-2 grain, every day 3 times, 4 days courses for the treatment of.
The preparation method of the Chinese medicine composition tablet of described treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make uniform granule, dry, be pressed into lamellar, sugar coating.
Instructions of taking: each 1-2 sheet, every day 3 times, 4 days courses for the treatment of.
The preparation method of the Chinese medicine composition pill of described treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 8-12 ball, every day 3 times, 4 days courses for the treatment of.
Beneficial effect of the present invention is mainly reflected in:
1, Chinese medicine composition of the present invention has effect of expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, clearing away phlegm dredging collateral, muscles and tendons relaxing to alleviate pain, has no side effect, and treatment sciatica is effective, is the favourable agents for the treatment of sciatica.
2, medicine source of the present invention is easy to get, and medical material cost is low, alleviates the financial burden of patient to a great extent.
3, the Chinese medicine composition that the present invention treats sciatica adopts that common Chinese medicine material is refining to be formed, and all medicine compatibilities are evident in efficacy, alleviate the misery of patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The pharmacological effect of each crude drug is respectively:
Olibanum: mildly bitter flavor, warm in nature.Have the fragrance of resin, colourless or faint yellow, green, blueness or brownish red that normal band is slight, also have minority to be hyaloid gloss.With faint yellow, graininess, translucent, glue hands, gas fragrance person for good without sandstone bark impurity, powder.There is regulating qi and activating blood, analgesic therapy, chase after effect of poison.For coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Radix Pteroxygoni Giraldii: bitter in the mouth, puckery, pungent, cool in nature.For the tuber of polygonaceae plant Pteroxygonum giraldii.Containing a small amount of anthraquinone, be mainly the sequestered anthraquinone of emodin and emodin methanol, and containing more tannin.There is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of removing damp and stopping pain.For laryngopharynx swelling and pain, furuncle toxic swelling, burn, spit blood, epistaxis, has blood in stool, metrorrhagia, and dysentery is had loose bowels, rheumatic arthralgia.
Scrofula grass: bitter in the mouth, pungent, property is put down.For Ofthe Primulaceae prolongs the herb of leaf Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).There is heat-clearing and toxic substances removing, effect of blood circulation promoting and dispersing pathogen accumulation.For sore throat, furuncle swelling toxin, menoxenia, traumatic injury.
Folium desmoris: bitter in the mouth, pungent, warm in nature.Return spleen, Liver Channel.For the leaf of annonaceae plant Desmos chinensis.There is expelling wind and removing dampness, blood-activating analgetic, invigorating the spleen and regulating the stomach, effect of preventing the attack (or recurrence) of malaria parasite killing.For rheumatic ostalgia, malaria, edema, traumatic injury, rubella, scabies, rotten foot.
Herba Otteliae Alismoidis: sweet in the mouth, light, cold nature.For the herb of Hydrocharctaceae vegetation water Herba Plantaginis.There is removing heat-phlegm, effect of removing toxic substances diuresis.For lung-heat cough with asthma, cough up phlegm yellow thick, edema, dysuria, carbuncle, burn.
Rhizoma Begoniae Willsonii: sweet in the mouth, hardship, cold nature.For the rhizome of Begoniaceae plant Rhizoma Begoniae Willsonii Flos Begoniae Evansianae.Containing cardiotonic glycoside, flavonoid, tannin, phenols component, sterol, Triterpenoid, Saponin.Having nourishes blood enriches blood, effect of eliminating stasis to stop pain.For weak after being ill, impairment caused by overstrain, blood deficiency amenorrhea, metrorrhagia, leucorrhea, spits blood, spitting of blood, epistaxis, traumatic hemorrhage, treating swelling and pain by traumatic injury.
Radix Nandinae Domesticae: bitter in the mouth, cold in nature.Return lung, Liver Channel.For the root of Berberidaceae plant Fructus Nandinae Domesticae.Containing Fructus Nandinae Domesticae kind alkali, Fructus Nandinae Domesticae kind alkali methyl ether, i.e. nandinine, Nan Tian's table alkali, berberine, and jateorhizine.There is cough-relieving, dehumidifying, dispelling pathogenic wind and eliminating phlegm, heat clearing away, effect of removing toxic substances.For cough due to lung-heat, jaundice due to damp-heat, diarrhoea, rheumatic arthralgia, skin infection, scrofula.
Herba Polygoni japonici: acrid in the mouth, warm in nature.For the herb of polygonaceae plant Herba Polygoni japonici.Containing cyanidin 3,5-diglucoside, cyanidin, delphinidin, malvidin.There is removing toxic substances, pain relieving, effect of rash.Swell and ache for skin infection, parasites is bitten, diarrhoea, dysentery, and the cold pain of waist knee joint, measles is sent out not smooth thoroughly.
Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae): sweet in the mouth, acid, puckery, property is put down.Return liver, spleen, stomach warp.For the fruit of rosaceous plant fire sour jujube.Containing multivitamin: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin B6,18 seed amino acids, linolenic acid, linoleic acid, oleic acid, protein and sugar, cupreol eriodictyol, globulariacitrin, miscanthoside, Isoquercitrin and Quercetin.There is spleen invigorating removing food stagnancy, convergence dysentery relieving, effect of pain relieving.For mass in the abdomen, food stagnation is stagnated, and distension and fullness in the abdomen, has loose bowels, dysentery, metrorrhagia, leukorrhagia, traumatic injury.
Rhizoma Typhonii: acrid in the mouth, sweet, warm in nature.Return stomach, Liver Channel.For the tuber of aroid Herba Typhonii gigantei.Containing cupreol, cupreol-D-Glucose glycoside, meso inositol, choline, uracil, succinic acid, cruel propylhomoserin, valine, Palmic acid, linoleic acid, oleic acid, Trilinoleyl glyceride, glycerol-1,3-dipalmitate, Lectin From Typhonium Gigantumiengl.There is the expectorant that dispels the wind, the meridian dredging, removing toxic substances analgesic effect.Stop up for middle wind-phlegm, facial hemiparalysis, migraine, tetanus, venom, scrofula tuberculosis, carbuncle.
Fructus Sorbi Pohuashanensis: sweet in the mouth, hardship, property is put down.For fruit, stem and peel of stem that rosaceous plant Fructus Sorbi Pohuashanensis is set.Containing volatile oil, steroidal, coumarin, flavonoid glycoside, cardiotonic glycoside, Saponin.There is relieving cough and expelling phlegm, effect of invigorating spleen for diuresis.For chronic tracheitis, pulmonary tuberculosis, edema.
Caulis fici pumilae (Fructus Fici Pumilae): sour in the mouth, cool in nature.For stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae).Containing herniarin, bergapten, meso inositol, globulariacitrin, cupreol, Pu Fuzhou, β-Amyrin acetic acid fat.There is expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, effect of removing toxic substances and promoting subsidence of swelling.For rheumatic arthralgia, sciatica, dysentery, urine drenches, edema, malaria, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, laryngopharynx swelling and pain, orchitis, dermatitis rhus, pain pyogenic infections from tumour or sore, traumatic injury.
Herba Circaeae mollis: acrid in the mouth, hardship, property is put down.For herb or the root of onagraceae plant Herba Circaeae mollis.There is expelling wind and removing dampness, promoting blood circulation and detumescence, effect of heat-clearing and toxic substances removing.For rheumatic arthralgia, traumatic injury congestive edema, acute mastitis, scrofula, skin ulcer swells, innominate toxic swelling, venom.
Herba Hyperici Sampsonii: acrid in the mouth, hardship, cold in nature.For the herb of Hypericaceae hypericum Herba Hyperici Sampsonii.There is heat-clearing and toxic substances removing, dredge the meridian passage, effect of cooling blood for hemostasis.For infantile hyperpyrexia, dysentery, enteritis, spits blood, epistaxis, menoxenia, leucorrhea; Traumatic hemorrhage is controlled in external, traumatic injury, mastitis, burn and scald, venom.
Tree head dish: bitter in the mouth, cold in nature.For stem, the leaf of Capparidaceae plant tree head dish.There is heat-clearing and toxic substances removing, effect of stomach invigorating.For acute filthy disease heating, rotten skin ulcer, venom, stomachache, rheumatic arthritis.
Fructus Tritici Levis: sweet in the mouth, cool in nature.GUIXIN warp.For the fruit of the frivolous lack of filling power of drying of grass family Triticum plant Semen Tritici aestivi.Have except deficiency-heat, effect of hidroschesis.For only fever due to yin deficiency, night sweat, spontaneous perspiration.
embodiment 1the Chinese medicine composition for the treatment of sciatica, takes off and states primary raw material and be prepared from (getting 50g for every part): Olibanum 8 parts; Radix Pteroxygoni Giraldii 10 parts; Scrofula grass 9 parts; Folium desmoris 11 parts; Herba Otteliae Alismoidis 8 parts; Rhizoma Begoniae Willsonii 6 parts; Radix Nandinae Domesticae 9 parts; Herba Polygoni japonici 8 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 7 parts; Rhizoma Typhonii 9 parts; Fructus Sorbi Pohuashanensis 7 parts; Caulis fici pumilae (Fructus Fici Pumilae) 8 parts; Herba Circaeae mollis 10 parts; Herba Hyperici Sampsonii 8 parts; Tree head dish 10 parts; Fructus Tritici Levis 9 parts.
The preparation method of the Chinese medicine composition oral liquid of above-mentioned treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2 days, change water every day 2 times, be placed in pot, add Rhizoma Zingiberis, boil rear continuation decoction 35 minutes, pull out, removing Rhizoma Zingiberis, dry, pulverize, and crosses 130 mesh sieves;
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, add ethanol, fully stir, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, and crosses 130 mesh sieves;
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol (consumption is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), floods 8 hours, filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct 25 minutes, add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 35 minutes, filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, add xylitol (consumption is 8% of filtrate 2 quality), mix homogeneously, high temperature sterilization 35 minutes, sterile packaged.
Instructions of taking: each 13ml, every day 3 times, 4 days courses for the treatment of.
embodiment 2the Chinese medicine composition for the treatment of sciatica, takes off and states primary raw material and be prepared from (getting 40g for every part): Olibanum 14 parts; Radix Pteroxygoni Giraldii 13 parts; Scrofula grass 15 parts; Folium desmoris 15 parts; Herba Otteliae Alismoidis 16 parts; Rhizoma Begoniae Willsonii 12 parts; Radix Nandinae Domesticae 14 parts; Herba Polygoni japonici 13 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 12 parts; Rhizoma Typhonii 13 parts; Fructus Sorbi Pohuashanensis 14 parts; Caulis fici pumilae (Fructus Fici Pumilae) 12 parts; Herba Circaeae mollis 16 parts; Herba Hyperici Sampsonii 15 parts; Tree head dish 14 parts; Fructus Tritici Levis 16 parts.
The preparation method of the Chinese medicinal composition granules of above-mentioned treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 3 days, change water every day 3 times, be placed in pot, add Rhizoma Zingiberis (consumption is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation decoction 35 minutes, pull out, removing Rhizoma Zingiberis, dry, pulverize, and crosses 130 mesh sieves;
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, add ethanol, fully stir, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, and crosses 130 mesh sieves;
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol, floods 8 hours, filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct 25 minutes, add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 35 minutes, filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, mix homogeneously, makes uniform fine particle, with the specification sterile packaged of every parcel 6g.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 4 days courses for the treatment of.
model case one:grandson XX, man, 47 years old, people from In Shandong Weihai.Without occurring under obvious inducement that waist buttocks is ached before 2 years, after several days, pain is radiated on rear side of thigh, until toes.So remove examination in hospital, lumbar vertebra is without tenderness, and it is positive that lower limb lift lower limb test, waist sacrum X-ray film ().Be diagnosed as sciatica, treatment will build one month, DeGrain.Nearly section time flank pain unbearably, is rest pain, period the mode such as Multiple through then out massage treat, but not alleviate to some extent.
Take after the present invention treats 2 courses for the treatment of of Chinese medicine composition of sciatica, pain obviously reduces, and the mental status is better.After continuing to take 2 courses for the treatment of, the reaction of patient's each side is good, and can work normally and live.Later stage visits and learns and fully recover, and does not recur.
embodiment 3the Chinese medicine composition for the treatment of sciatica, takes off and states primary raw material and be prepared from (getting 20g for every part): Olibanum 10 parts; Radix Pteroxygoni Giraldii 11 parts; Scrofula grass 11 parts; Folium desmoris 12 parts; Herba Otteliae Alismoidis 11 parts; Rhizoma Begoniae Willsonii 8 parts; Radix Nandinae Domesticae 11 parts; Herba Polygoni japonici 10 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9 parts; Rhizoma Typhonii 10 parts; Fructus Sorbi Pohuashanensis 10 parts; Caulis fici pumilae (Fructus Fici Pumilae) 9 parts; Herba Circaeae mollis 12 parts; Herba Hyperici Sampsonii 11 parts; Tree head dish 11 parts; Fructus Tritici Levis 12 parts.
The preparation method of the Chinese medicinal composition capsules of above-mentioned treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2 days, change water every day 2 times, be placed in pot, add Rhizoma Zingiberis (consumption is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation decoction 35 minutes, pull out, removing Rhizoma Zingiberis, dry, pulverize, and crosses 130 mesh sieves;
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, add ethanol, fully stir, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, and crosses 130 mesh sieves;
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol (consumption is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), floods 8 hours, filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct 25 minutes, add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 35 minutes, filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder, make capsule by the specification of 0.5g/ grain.
Using method: each 1-2 grain, every day 3 times, 4 days courses for the treatment of.
embodiment 4the Chinese medicine composition for the treatment of sciatica, takes off and states primary raw material and be prepared from (getting 20g for every part): Olibanum 12 parts; Radix Pteroxygoni Giraldii 12 parts; Scrofula grass 13 parts; Folium desmoris 14 parts; Herba Otteliae Alismoidis 13 parts; Rhizoma Begoniae Willsonii 10 parts; Radix Nandinae Domesticae 13 parts; Herba Polygoni japonici 12 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 11 parts; Rhizoma Typhonii 12 parts; Fructus Sorbi Pohuashanensis 12 parts; Caulis fici pumilae (Fructus Fici Pumilae) 11 parts; Herba Circaeae mollis 14 parts; Herba Hyperici Sampsonii 13 parts; Tree head dish 13 parts; Fructus Tritici Levis 14 parts.
The preparation method of the Chinese medicine composition tablet of above-mentioned treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 3 days, change water every day 3 times, be placed in pot, add Rhizoma Zingiberis (consumption is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation decoction 35 minutes, pull out, removing Rhizoma Zingiberis, dry, pulverize, and crosses 130 mesh sieves;
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, add ethanol, fully stir, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, and crosses 130 mesh sieves;
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol (consumption is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), floods 8 hours, filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct 25 minutes, add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 35 minutes, filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filters, be concentrated into relative density 1.15(40 DEG C) thick paste, make uniform granule, dry, be pressed into lamellar, sugar coating.
Instructions of taking: each 1-2 sheet, every day 3 times, 4 days courses for the treatment of.
model case two:field XX, female, 41 years old, people from Rizhao City, Shandong Province.The both legs numb pain time more than a year, with left lower limb for work, sometimes walk lamely, waist is aching and tired, limitation of activity, walking pain increases the weight of, to squat down difficulty, seriously have impact on daily life and work, so remove examination in hospital, checked by spine X-ray plain film, lumbar vertebra CT etc. and be diagnosed as sciatica, treating pain after one week does not have material alterations.Occurred again that lower limb to little toe burnt sample severe pain afterwards, joint stuffiness, through with treatments such as Chinese and western drugs, massage, acupuncture, the state of an illness is without improvement.
Take after the present invention treats 2 courses for the treatment of of Chinese medicine composition of sciatica, leg pain obviously alleviates, and squats down and walks and obviously improve, the aching and limp basic disappearance of leg.After continuing to take 2 courses for the treatment of, pain disappears substantially, walks, squats down freely, and the later stage visits and learns that lumbago and skelalgia disappears, and fully recovers, so far without recurrence.
embodiment 5the Chinese medicine composition for the treatment of sciatica, takes off and states primary raw material and be prepared from (getting 20g for every part): Olibanum 11 parts; Radix Pteroxygoni Giraldii 11.5 parts; Scrofula grass 12 parts; Folium desmoris 13 parts; Herba Otteliae Alismoidis 12 parts; Rhizoma Begoniae Willsonii 9 parts; Radix Nandinae Domesticae 12 parts; Herba Polygoni japonici 11 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 10 parts; Rhizoma Typhonii 11 parts; Fructus Sorbi Pohuashanensis 11 parts; Caulis fici pumilae (Fructus Fici Pumilae) 10 parts; Herba Circaeae mollis 13 parts; Herba Hyperici Sampsonii 12 parts; Tree head dish 12 parts; Fructus Tritici Levis 13 parts.
The preparation method of the Chinese medicine composition pill of above-mentioned treatment sciatica, step is as follows:
(1) cut into slices by Radix Nandinae Domesticae, soak 2 days, change water every day 2 times, be placed in pot, add Rhizoma Zingiberis (consumption is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation decoction 35 minutes, pull out, removing Rhizoma Zingiberis, dry, pulverize, and crosses 130 mesh sieves;
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, add ethanol, fully stir, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, and crosses 130 mesh sieves;
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol (consumption is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), floods 8 hours, filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct 25 minutes, add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 35 minutes, filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 4 days courses for the treatment of.
test example:in order to verify that the present invention treats the curative effect of the Chinese medicine composition (embodiment 5) of sciatica, we are in May ,-2011 in June, 2009,250 routine sciatica patients are screened in Duo Suo hospital, minimal ages 18 years old, max age 62 years old, be divided into experimental group and matched group (wherein, experimental group 150 people, matched group 100 people) at random.
Diagnostic criteria: 1. pain is mainly limited to sciatic nerve areal area, outside and foot after back of thighs, shank.2. the degree difference that goes down of muscular strength is very large, and sciatic nerve can be had to arrange the weak or paralysis of all or part of power of muscle.3. can to have or without the tenderness of incisura ischiadica place sciatic nerve-trunk.4. have sciatic nerve tractive to levy, lasegue levies and equipotential levies the positive, local anaesthesia sciatic nerve root or nerve trunk this levy and can disappear.5. Achilles tendon reflex goes down or disappears, and quadriceps reflex can increase because of stimulation.6. sciatic nerve can be had to arrange going down or disappearing of the various sensations in region, comprise the pallhypesthesia of external malleolus, also can have extremely light sensory disturbance.
Experimental group takes the Chinese medicine composition pill that the present invention treats sciatica, each 10 balls, every day 3 times, 4 days courses for the treatment of.Matched group: take other drug, as anluotone tablet, muscle relaxing waist strengthening ball etc., wherein anluotone tablet, oral, one time 2,2-3 time on the one.Muscle relaxing waist strengthening ball, oral, a 5g, 3 times on the one.
Curative effect judging standard: cure: symptom and sign all disappear, and lower limb exercise freely; Effective: symptom and sign are improved comparatively large, but can have during tired and Changes in weather and increase the weight of; Invalid: after treatment, sings and symptoms is without significant change.
Every day, equal conditions was observed with after drug administration under the time, and take the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of the Chinese medicine composition of sciatica, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, at 18-35 year age bracket, take the present invention and treat the effective percentage of the Chinese medicine composition of sciatica up to 97.9%, cure rate is up to 78.8%, and the effective percentage taking other drug is 88.9%, and cure rate is only 66.7%; At 36-50 year age bracket, take the present invention and treat the effective percentage of the Chinese medicine composition of sciatica up to 95.2%, cure rate is up to 74.2%, and the effective percentage taking other drug is 83.7%, and cure rate is only 58.1%; At 51-62 year age bracket, take the present invention and treat the effective percentage of the Chinese medicine composition of sciatica up to 90.2%, cure rate is up to 70.7%, and the effective percentage taking other drug is 76.7%, and cure rate is only 46.7%.And can find out, no matter be experimental group or matched group, along with the increase at age, therapeutic effect declines to some extent, so should treat as early as possible, in case delay the timely treatment of the state of an illness.So Chinese medicine composition of the present invention is the favourable agents simply for the treatment of sciatica.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the Chinese medicine composition of sciatica, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Olibanum 8-14 part; Radix Pteroxygoni Giraldii 10-13 part; The careless 9-15 part of scrofula; Folium desmoris 11-15 part; Herba Otteliae Alismoidis 8-16 part; Rhizoma Begoniae Willsonii 6-12 part; Radix Nandinae Domesticae 9-14 part; Herba Polygoni japonici 8-13 part; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 7-12 part; Rhizoma Typhonii 9-13 part; Fructus Sorbi Pohuashanensis 7-14 part; Caulis fici pumilae (Fructus Fici Pumilae) 8-12 part; Herba Circaeae mollis 10-16 part; Herba Hyperici Sampsonii 8-15 part; Tree head dish 10-14 part; Fructus Tritici Levis 9-16 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 10-12 part; Radix Pteroxygoni Giraldii 11-12 part; The careless 11-13 part of scrofula; Folium desmoris 12-14 part; Herba Otteliae Alismoidis 11-13 part; Rhizoma Begoniae Willsonii 8-10 part; Radix Nandinae Domesticae 11-13 part; Herba Polygoni japonici 10-12 part; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9-11 part; Rhizoma Typhonii 10-12 part; Fructus Sorbi Pohuashanensis 10-12 part; Caulis fici pumilae (Fructus Fici Pumilae) 9-11 part; Herba Circaeae mollis 12-14 part; Herba Hyperici Sampsonii 11-13 part; Tree head dish 11-13 part; Fructus Tritici Levis 12-14 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 11 parts; Radix Pteroxygoni Giraldii 11.5 parts; Scrofula grass 12 parts; Folium desmoris 13 parts; Herba Otteliae Alismoidis 12 parts; Rhizoma Begoniae Willsonii 9 parts; Radix Nandinae Domesticae 12 parts; Herba Polygoni japonici 11 parts; Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 10 parts; Rhizoma Typhonii 11 parts; Fructus Sorbi Pohuashanensis 11 parts; Caulis fici pumilae (Fructus Fici Pumilae) 10 parts; Herba Circaeae mollis 13 parts; Herba Hyperici Sampsonii 12 parts; Tree head dish 12 parts; Fructus Tritici Levis 13 parts.
4., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable oral liquid, preparation method is:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis, boil rear continuation and decoct 30-40 minute (preferably continue to decoct 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, (consumption of preferred xylitol is the 7%-9% of filtrate 2 quality to add xylitol, the consumption being more preferably xylitol is 8% of filtrate 2 quality), mix homogeneously, high temperature sterilization 30-40 minute (preferred high temperature sterilization 33-37 minute, be more preferably high temperature sterilization 35 minutes), sterile packaged.
5. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: the consumption of the preferred Rhizoma Zingiberis of step (1) is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality.
6., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, puts into container, adds ethanol, floods 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filters, obtain filtrate 1 and filtering residue after stirring;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), mix homogeneously, makes uniform fine particle, with the specification sterile packaged of every parcel 6g.
7. the preparation method of Chinese medicine composition according to claim 6, it is characterized in that: the consumption of step (3) preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass.
8., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, be concentrated into the thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15) of relative density 1.10-1.20, dry, pulverize, obtain medicated powder, make capsule by the specification of 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain).
9., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make uniform granule, dry, be pressed into lamellar, sugar coating.
10., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is:
(1) cut into slices by Radix Nandinae Domesticae, soak 2-3 days, every day changes water 2-3 time, be placed in pot, add Rhizoma Zingiberis (consumption of preferred Rhizoma Zingiberis is the 15%-20% of Radix Toddaliae Asiaticae quality, and the consumption being more preferably Rhizoma Zingiberis is 18% of Radix Toddaliae Asiaticae quality), boil rear continuation and decoct 30-40 minute (preferably continuation decoction 33-37 minute, be more preferably and continue decoction 35 minutes), pull out, removing Rhizoma Zingiberis, dry, pulverize, excessively 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(2) scrofula grass, Herba Polygoni japonici and Herba Hyperici Sampsonii are made coarse powder, water extraction twice, boil 1 hour at every turn, twice filtrate merges, and is concentrated into paste, adds ethanol, abundant stirring, washing, puts on cloth funnel and is separated, discard ethanol mother liquor, precipitation, dry, pulverize, cross 120-140 mesh sieve (preferred 126-134 mesh sieve excessively, was more preferably 130 mesh sieves);
(3) Folium desmoris, Rhizoma Typhonii and tree head dish are smashed, mix homogeneously, put into container, (consumption of preferred alcohol is the 20%-30% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass to add ethanol, the consumption being more preferably ethanol is 25% of Folium desmoris, Rhizoma Typhonii and tree head dish gross mass), flood 6-9 hour (preferably dipping 7-8 hour, is more preferably dipping 7.5 hours), filter after stirring, obtain filtrate 1 and filtering residue;
(4) Radix Pteroxygoni Giraldii, Rhizoma Begoniae Willsonii, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Fructus Sorbi Pohuashanensis and Fructus Tritici Levis are placed in marmite, add filtrate 1, decoct and (preferably decoct 23-27 minute in 20-30 minute, be more preferably decoction 25 minutes), add step (3) gained filtering residue, Olibanum, Herba Otteliae Alismoidis, Caulis fici pumilae (Fructus Fici Pumilae) and Herba Circaeae mollis, decoct with water 30-40 minute (preferably decoct with water 33-37 minute, be more preferably and decoct with water 35 minutes), filter, obtain filtrate 2;
(5) step (1)-(2) gained medicated powder is joined in filtrate 2, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412800A (en) * | 2015-12-29 | 2016-03-23 | 青岛昌安达药业有限公司 | Traditional Chinese medicinal preparation for sciatica patients to administrate |
| CN105477524A (en) * | 2015-12-29 | 2016-04-13 | 青岛昌安达药业有限公司 | Traditional Chinese medicine for patients with sciatica |
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| CN102872387A (en) * | 2012-10-11 | 2013-01-16 | 王慧艳 | Traditional Chinese medicine composition for treating arthralgia caused by wind-damp-heat pathogens |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412800A (en) * | 2015-12-29 | 2016-03-23 | 青岛昌安达药业有限公司 | Traditional Chinese medicinal preparation for sciatica patients to administrate |
| CN105477524A (en) * | 2015-12-29 | 2016-04-13 | 青岛昌安达药业有限公司 | Traditional Chinese medicine for patients with sciatica |
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