CN105362887A - Prescription for treating leukemia and preparation method - Google Patents
Prescription for treating leukemia and preparation method Download PDFInfo
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Abstract
The invention discloses a prescription for treating leukemia. The prescription is mainly prepared from, by mass, 6-10 parts of Polygala tenuifolia, 8-13 parts of Herba rubiae yunnanensis, 5-9 parts of Herba schizonepetae, 7-12 parts of Camellia, 6-13 parts of Semen loti, 8-14 parts of Leucosceptrum canum, 4-10 parts of Changnienia amoena chien, 6-11 parts of Cladonia alpestris, 8-12 parts of Fructus liquidambaris, 7-13 parts of Rhizoma arundinis, 3-9 parts of Actinidia arguta, 7-11 parts of pollen typhae, 9-12 parts of Capsella bursapastoris medic and 3-6 parts of Alpinia katsumadai. The prescription is a pure traditional Chinese medicine preparation, and active pharmaceutical ingredients are synergistic and free of obvious toxic and side effect; the prescription is prepared according to rules of traditional Chinese medicine, has efficacy of tonifying qi and nourishing yin and enriching and activating blood, has good treatment effect and is low in cost, easy for patients to accept and worthy of popularization.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat leukemic prescription and preparation method.
Background technology
Leukemia is the malignant neoplastic disease of hemopoietic system, also known as " leukemia ".Certain precursor that is a series of, mainly a certain leukocyte series of hematopoietic cell loses differentiation and maturation ability, be malignant clone hypertrophy in bone marrow and in other hemopoietic tissue, gather, and invade liver, spleen, lymph node, final infiltration destroys body tissue, organ, and normal hematopoiesis function is suppressed.Leukemia is different from entity tumor, be not the vegetation of growth in local, but whole body disseminates, and may invade the malignant hematologic disease of each system, Organ and tissue.Clinical manifestation be anemia, hemorrhage, infect and each organ infiltration's symptom.Leukemia occupies first in the sickness rate of pediatric malignancies.Be characterized in there is a large amount of leukaemia unrestrictedly hypertrophy in bone marrow and other hemopoietic tissue, and enter peripheral blood, and the manufacture of normal plasma cell is obviously suppressed.Mainly occur in bone marrow and other hemopoietic tissue, also can appear in other tissue of whole body, cause normal erythroid cells, Megakaryocyte significantly reduces.According to proliferative cell type, granulocytic, lymphatic and monocarpotic cellularity three class can be divided into.Acute and chronic two large classes can be divided into by leukaemia's differentiation degree.Acute leukemia morbidity is anxious, and mainly germinal cell in bone marrow and peripheral blood, if it is often dead within half a year not treat patient.Patient is prominent sense fear of cold, heating, headache, weak, exhaustion, inappetence, Nausea and vomiting, stomachache, abdominal distention often, often there are skin, nose, oral cavity, gingiva bleeding gingival hemorrhage, severe patient can have hematemesis, has blood in stool, hematuria, optical fundus and intracranial hemorrhage etc., and there is Progressive symmetric erythrokeratodermia anemia, develop very rapid.Chronic leukemia onset is slow, how asymptomatic in early days, is everlasting when seeing other diseases blood count and stumbles on.So a lot of patient does not have symptom, patient especially in early days, along with the progress of disease, leukemia destroys bone marrow normal hematopoiesis function, infiltrates organ, causes obvious but non-specific symptom.As anemia, repeated infection and not easily cure, the becoming thin and night sweat etc. of bleeding tendency, splenomegaly, unknown cause.
Publication No. CN104721272A(application number 201510175243.3) Chinese patent literature disclose one and treat leukemic medicine, its composition consists of: Herba Artemisiae Scopariae 10g, Fructus Forsythiae 10g, Alumen 10g, Flos Lonicerae 10g, loess 30g, Herba Taraxaci 10g, Radix Glycyrrhizae 10g, Radix Scutellariae 10g.Publication No. CN103585548A(application number 201310584670.8) Chinese patent literature disclose one and treat leukemic Chinese medicine preparation, it is made up of Chinese herbal medicine such as the Radix Astragali, Radix Salviae Miltiorrhizae, Crinis Carbonisatus, Fructus Ligustri Lucidi, Radix Rehmanniae, Indigo Naturalis, Cortex Moutan, Radix Rehmanniae Preparata, Fructus Forsythiae, Concha Ostreae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Herba Hedyotidis Diffusae, Herba Senecionis Kirilowi, Herba Scutellariae Barbataes.Publication No. CN104922282A(application number 201410109605.4) Chinese patent literature disclose a kind of Chinese medicine of dedicated for treating leukemia, this Chinese medicine is by following weight portion composition: Radix Angelicae Sinensis 1-8 parts; Radix Codonopsis 10-15 parts; Radix Salviae Miltiorrhizae 2-5 parts; 12-19 parts, Colla Corii Asini; The Radix Astragali 5-13 parts; 9-15 parts, Radix Rehmanniae Preparata.
The leukemia course of disease is long, the state of an illness easily repeatedly, increase treatment difficulty, the leukemic method of existing treatment has medicine (as nilotinib, person's Dasatinib), chemotherapy and radiation, but these method side effect are larger, and cure rate is low, easy recurrence, somewhat expensive, and be not suitable for most of patients, Chinese medicine think leukemic morbidity many interior deficient, negative and positive are become estranged, evil etc. the taking advantage of a weak point in opponent's defence of warm poison and caused by people on the basis of internal organs weakness, dialectical treatmert or typing opinion can control, improve the resistance against diseases of body, palliating leukemia.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, the easily leukemic prescription for the treatment of of clothes and preparation method for a long time.
Technical scheme of the present invention is:
Treat leukemic prescription, be prepared from primarily of following bulk drugs, be mass parts: Radix Polygalae 6-10, Herba Rubiae Yunnanensis 8-13, Herba Schizonepetae 5-9, Flos Camelliae Japonicae 7-12, Semen Caesalpiniae Minacis 6-13, meter Tuan Hua 8-14, Changuienia amoena Chien 4-10, Cladonia alpestris (L.) Rabenh. 6-11, Fructus Liquidambaris 8-12, Rhizoma Arundinis Donacis 7-13, Fructus Actinidiae Argutae 3-9, Pollen Typhae 7-11, Flos Capsellae 9-12, Semen Alpiniae Katsumadai 3-6.
In preferred scheme, Radix Polygalae 7-9, Herba Rubiae Yunnanensis 9-12, Herba Schizonepetae 6-8, Flos Camelliae Japonicae 9-10, Semen Caesalpiniae Minacis 8-11, meter Tuan Hua 10-12, Changuienia amoena Chien 6-8, Cladonia alpestris (L.) Rabenh. 7-10, Fructus Liquidambaris 9-11, Rhizoma Arundinis Donacis 9-11, Fructus Actinidiae Argutae 4-8, Pollen Typhae 8-10, Flos Capsellae 10-11, Semen Alpiniae Katsumadai 4-5.
Be more preferably, Radix Polygalae 8, Herba Rubiae Yunnanensis 10.5, Herba Schizonepetae 7, Flos Camelliae Japonicae 9.5, Semen Caesalpiniae Minacis 9.5, meter Tuan Hua 11, Changuienia amoena Chien 7, Cladonia alpestris (L.) Rabenh. 8.5, Fructus Liquidambaris 10, Rhizoma Arundinis Donacis 10, Fructus Actinidiae Argutae 6, Pollen Typhae 9, Flos Capsellae 10.5, Semen Alpiniae Katsumadai 4.5.
The preparation method of the powder of the leukemic prescription of described treatment, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug are pulverized and sieved together, make medicated powder, medicated powder stirring and evenly mixing made with step (4), then add adjuvant, sterilizing, obtain powder.
The preparation method of the leukemic prescription powder of described treatment, step (5) pulverized 200-400 mesh sieve (preferred, to pulverize 300 mesh sieves).
The preparation method of the tablet of the leukemic prescription of described treatment, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, make medicated powder, load in penetrating bag, decoct with water 3 times, each big fire is boiled rear little fire and is continued to decoct 20-28 minute (preferred, little fire continues to decoct 22-26 minute; Be more preferably, little fire continues to decoct 24 minutes), collecting by filtration filtrate, merges three gained filtrates, concentrated, lyophilization, make medicated powder, and mix with step (4) made medicated powder, add 10% starch slurry and cane sugar powder soft material, granulate, dry, granulate, adds Pulvis Talci, tabletting, and sterilizing obtains tablet.
The preparation method of the leukemic prescription tablet of described treatment, doubly (preferred, the 6-7 that each added water amount is the quality of boiled crude drug is doubly for the 5-8 that the amount that step (5) is each added water is the quality of boiled crude drug; Be more preferably, 6.5 times of the quality that each added water amount is boiled crude drug).
The preparation method of the capsule of the leukemic prescription of described treatment, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, and made medicated powder, load in penetrating bag, decoct with water 3 times (6.5 times of the quality that each added water amount is boiled crude drug), each big fire is boiled rear little fire and is continued to decoct 20-28 minute, collecting by filtration filtrate, merge three gained filtrates, concentrated, lyophilization, makes medicated powder, and mix with step (4) made medicated powder, granule processed, incapsulates, and obtains capsule.
The preparation method of the leukemic prescription capsule of described treatment, step (5) little fire continues to decoct 22-26 minute (preferred, little fire continues to decoct 24 minutes).
The preparation method of the decoction of the leukemic prescription of described treatment, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) together with Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis and step (1) (3) made crude drug, decocting in water is added, the amount added water is 6 times of boiled crude drug quality, big fire is boiled rear little fire and is boiled 30-36 minute (preferably, little fire boils 31-35 minute, be more preferably, little fire boils 33 minutes), filter, collect filtrate;
(5) Pollen Typhae, Flos Capsellae and step (2) made crude drug are pulverized and sieved together, make medicated powder, join in step (4) made filtrate and mix, sterilizing, obtains decoction.
The preparation method of the leukemic prescription decoction of described treatment, step (5) was pulverized 180-260 mesh sieve and (preferably, was pulverized 200-240 mesh sieve; Be more preferably, pulverized 220 mesh sieves).
The leukemic prescription for the treatment of provided by the invention, preparation is simple, selection science, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, the present invention is pure Chinese medicinal preparation, and synergism between crude drug, without obvious toxic-side effects;
2, this prescription is according to the development of Chinese medicine principle, has supplementing QI and nourishing YIN, effect such as to invigorate blood circulation of enriching blood;
3, good effect of the present invention, cost is low, and patient easily accepts, and is worthy to be popularized.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Polygalae: base is former: be the root of milk wort Roots of Polygala tenuifolia.Nature and flavor: bitter, pungent, warm.Gui Jing: GUIXIN, kidney, lung meridian.Function cures mainly: Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Herba Rubiae Yunnanensis: base is former: for the aerial parts of grass is wished in Maguireothamnus speciosus Yunnan.Nature and flavor: sweet are flat.Function cures mainly: enrich blood and invigorate blood circulation, expelling wind and removing dampness.Main anemia, dizzy insomnia, rheumatic arthralgia, chronic gastritis, traumatic injury, menoxenia.
Herba Schizonepetae: base is former: be the herb of labiate Herba Schizonepetae.Nature and flavor: pungent, tepor.Gui Jing: return lung, Liver Channel.Function cures mainly: induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Flos Camelliae Japonicae: base is former: be the flower of plant of theaceae Flos Camelliae Japonicae.Nature and flavor: pungent, bitter, cold.Gui Jing: enter liver, lung two warp.Function cures mainly: convergence removing heat from blood, hemostasis.For spitting blood, epistaxis, has blood in stool, metrorrhagia, and burn and scald is controlled in external, wound hemorrhage.
Semen Caesalpiniae Minacis: base is former: be the fruit that nymphaeaceae plant lotus is aging.Nature and flavor: sweet, micro-hardship are flat.Function cures mainly: invigorating the spleen to arrest diarrhea.For chronic dysentery, inappetence.
Meter Tuan Hua: base is former: be leaf or the root bark of labiate Mel tree.Nature and flavor: bitter in the mouth, cool in nature.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and synthetism is stopped blooding.The hot lossless innominate toxic swelling of main height, impetigo, pyogenic infection of the bone, injury and bone fracture, traumatic hemorrhage.
Changuienia amoena Chien: base is former: be pseudobulb and the herb of orchid Herba Changnieniae amoenae.Nature and flavor: bitter in the mouth, cold in nature.Function cures mainly: heat clearing away, removing heat from blood, removing toxic substances.Main cough, sputum mixed with blood, furuncle furuncle.
Cladonia alpestris (L.) Rabenh.: base is former: be the dendrimer of Cladoniaceae plant passeris montani saturati Herba Cladoniae rangiferinae.Nature and flavor: light are flat.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, regulating menstruation, hemostasis.For having a dizzy spell, hypertension, migraine, epistaxis, metrorrhagia, menoxenia, leucorrhea.
Fructus Liquidambaris: base is former: be the fruit of Hamamelidaceae Plants sweetgum.Nature and flavor: bitter are flat.Gui Jing: return liver, kidney channel.Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Rhizoma Arundinis Donacis: base is former: be the rhizome of grass Arundo donax.Nature and flavor: bitter, cold.Function cures mainly: clearing away heat and promoting diuresis.Control calentura to go mad, asthenia hectic fever due to YIN-deficiency, gonorrhea, dysuria, acute toothache.
Fructus Actinidiae Argutae: base is former: be the fruit of Actinidiaceae plant Actinidia arguta Sieb.et Zucc.Nature and flavor: sweet, micro-acid, is slightly cold.Gui Jing: stomach warp.Function cures mainly: nourishing YIN and clearing away heat, and relieving restlessness is quenched the thirst, and can drench.Main calentura Tianjin wound or deficiency of YIN-blood, excessive thirst taking fluids profusely, sand Stranguria, stranguria caused by urinary stone, vitamin C deficiency, gingival hemorrhage, hepatitis, does nourishing the human Body agent more.
Pollen Typhae: base is former: for Typhaceae plant typha angustata, typha angustifolia, common cattail or its belong to the pollen of various plants together.Nature and flavor: sweet are flat.Gui Jing: return liver, pericardium channel.Function cures mainly: hemostasis, and blood stasis dispelling is treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Flos Capsellae: base is former: be the inflorescence of crucifer Herba Capsellae.Nature and flavor: sweet are cool.Gui Jing: large intestine channel.Function cures mainly: cooling blood for hemostasis, clearing away heat-damp and promoting diuresis.Main dysentery, metrorrhagia, hematuria, leaf blood, spitting of blood, epistaxis, children's's infantile dyspepsia, leucorrhea with red and white discharge.
Semen Alpiniae Katsumadai: base is former: be the seed group of greedy section plant plait Fructus Amomi Rotundus.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: warming middle-JIAO, cold relieving, circulation of qi promoting, dampness.Control trusted subordinate's cold type of pain, feeling of fullness dyspepsia, dysphagia and regurgitation, cold-damp is vomited and diarrhoea, and phlegm retention is gathered.
embodiment 1treat leukemic prescription, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Polygalae 6 parts, Herba Rubiae Yunnanensis 8 parts, Herba Schizonepetae 5 parts, Flos Camelliae Japonicae 7 parts, Semen Caesalpiniae Minacis 6 parts, meter Tuan Hua 8 parts, Changuienia amoena Chien 4 parts, Cladonia alpestris (L.) Rabenh. 6 parts, Fructus Liquidambaris 8 parts, Rhizoma Arundinis Donacis 7 parts, Fructus Actinidiae Argutae 3 parts, Pollen Typhae 7 parts, Flos Capsellae 9 parts, Semen Alpiniae Katsumadai 3 parts.
The preparation method of the leukemic prescription powder of above-mentioned treatment is:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1.5 hours, sucking filtration, merge extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug are pulverized 300 mesh sieves together, made medicated powder, medicated powder stirring and evenly mixing made with step (4), then added adjuvant, sterilizing, obtain powder.
embodiment 2treat leukemic prescription, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Polygalae 10 parts, Herba Rubiae Yunnanensis 13 parts, Herba Schizonepetae 9 parts, Flos Camelliae Japonicae 12 parts, Semen Caesalpiniae Minacis 13 parts, meter Tuan Hua 14 parts, Changuienia amoena Chien 10 parts, Cladonia alpestris (L.) Rabenh. 11 parts, Fructus Liquidambaris 12 parts, Rhizoma Arundinis Donacis 13 parts, Fructus Actinidiae Argutae 9 parts, Pollen Typhae 11 parts, Flos Capsellae 12 parts, Semen Alpiniae Katsumadai 6 parts.
The preparation method for the treatment of leukemic prescription tablet is:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1.5 hours, sucking filtration, merge extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, make medicated powder, load in penetrating bag, decoct with water 3 times (6.5 times of the quality that each added water amount is boiled crude drug), each big fire is boiled rear little fire and is continued to decoct 24 minutes, collecting by filtration filtrate, merge three gained filtrates, concentrated, lyophilization, make medicated powder, and mix with step (4) made medicated powder, add 10% starch slurry and cane sugar powder soft material, granulate, dry, granulate, adds Pulvis Talci, tabletting, sterilizing, obtains tablet.
Model case: xxx, female, 6 years old.Before three months, because of heating, Progressive symmetric erythrokeratodermia basin blood, pale complexion is weak, lymphadenectasis, hospital admission, is diagnosed as the acute lymphoblastic leukemia catabasis, after be admitted to hospital and accept radiotherapy and western medicine, symptom is improved, diet and sleep recover still can, rear because cannot medical expense be born, then use Chinese traditional treatment instead.
Take the present embodiment gained and treat leukemic prescription tablet, every day 2 times, each 3, warm water delivery service, 21 days courses for the treatment of.After taking a course for the treatment of, complexion takes a turn for the better, and spirit is good, appetite increases, and after taking two courses for the treatment of, bone marrow smear shows, nucleated red blood cell hypertrophy, accounts for 52.1%, the active proliferation of grain system, middle late erythrocytosis, partial rcsponse, after taking four courses for the treatment of, patient's complexion has China, and Hemogram is all normal, patient's complete incidence graph, follow up a case by regular visits to after 1 year, the state of an illness is without repeatedly.
embodiment 3treat leukemic prescription, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Polygalae 7 parts, Herba Rubiae Yunnanensis 9 parts, Herba Schizonepetae 6 parts, Flos Camelliae Japonicae 9 parts, Semen Caesalpiniae Minacis 8 parts, meter Tuan Hua 10 parts, Changuienia amoena Chien 6 parts, Cladonia alpestris (L.) Rabenh. 7 parts, Fructus Liquidambaris 9 parts, Rhizoma Arundinis Donacis 9 parts, Fructus Actinidiae Argutae 4 parts, Pollen Typhae 8 parts, Flos Capsellae 10 parts, Semen Alpiniae Katsumadai 4 parts.
The preparation method for the treatment of leukemic prescription capsule is:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1.5 hours, sucking filtration, merge extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, and made medicated powder, load in penetrating bag, decoct with water 3 times (6.5 times of the quality that each added water amount is boiled crude drug), each big fire is boiled rear little fire and is continued to decoct 24 minutes, collecting by filtration filtrate, merge three gained filtrates, concentrated, lyophilization, makes medicated powder, and mix with step (4) made medicated powder, granule processed, incapsulates, and obtains capsule.
Model case: xxx, female, 16 years old.Main suit: the high heat of the appearance without obvious inducement, malasia is weak, and complexion is pale, takes febrifuge, DeGrain, hospital admission, anemia looks, and skin is without petechia, and whole body superficial lymph knot is without enlargement, and cardio-pulmonary function is normal, routine blood test leukocyte 3.0 × 10
9/ L, bone marrow smear inspection, nucleated red blood cell accounts for 40% of whole nucleated cell, and germinal cell 45%, is finally diagnosed as acute lymphoblastic leukemia.
Take the present embodiment gained and treat leukemic prescription capsule, adopt every day 2 times, each 4, with warm water delivery service, 21 days courses for the treatment of.After taking one week, temperature recovery is normal, and after taking two courses for the treatment of, complexion is slightly improved, and blood marrow resembles alleviation, and after taking four courses for the treatment of, patient's complexion is ruddy, and appetite is normal, and check, the equal complete incidence graph of Hemogram, follows up a case by regular visits to after 1 year, have no recurrence.
embodiment 4treat leukemic prescription, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Polygalae 9 parts, Herba Rubiae Yunnanensis 12 parts, Herba Schizonepetae 8 parts, Flos Camelliae Japonicae 10 parts, Semen Caesalpiniae Minacis 11 parts, meter Tuan Hua 12 parts, Changuienia amoena Chien 8 parts, Cladonia alpestris (L.) Rabenh. 10 parts, Fructus Liquidambaris 11 parts, Rhizoma Arundinis Donacis 11 parts, Fructus Actinidiae Argutae 8 parts, Pollen Typhae 10 parts, Flos Capsellae 11 parts, Semen Alpiniae Katsumadai 5 parts.
The preparation method for the treatment of leukemic prescription decoction is:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) together with Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis and step (1) (3) made crude drug, add decocting in water, the amount added water is 6 times of boiled crude drug quality, and big fire is boiled rear little fire and boiled 33 minutes, filters, and collects filtrate;
(5) Pollen Typhae, Flos Capsellae and step (2) made crude drug were pulverized 220 mesh sieves together, and made medicated powder, join in step (4) made filtrate and mix, sterilizing, obtains decoction.
Model case: xxx, man, 60 years old.Because of heating, pale complexion, hospital admission, bone marrow aspiration inspection is diagnosed as acute nonlymphocytic leukemia, after carrying out HA chemotherapy, hemogram partial rcsponse, but still heating (38.4 DEG C), malasia is weak, dizziness and tinnitus, xerostomia pharyngalgia, poor appetite, two lower limbs edema, uses Chinese traditional treatment instead then.
Take the present embodiment gained and treat leukemic prescription decoction, adopt every day 2 times, each 300-400ml(is warm), 21 days courses for the treatment of.After taking one week, without heating, weakly to alleviate, the diseases such as dizziness and tinnitus are eliminated, and after taking three courses for the treatment of, patient's complexion is clearly better, and appetite improves, and condition is good, can orthobiosis, and Hemogram all close to normally, is followed up a case by regular visits to after 1 year and had no recurrence.
embodiment 5treat leukemic prescription, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Polygalae 8 parts, Herba Rubiae Yunnanensis 10.5 parts, Herba Schizonepetae 7 parts, Flos Camelliae Japonicae 9.5 parts, Semen Caesalpiniae Minacis 9.5 parts, meter Tuan Hua 11 parts, Changuienia amoena Chien 7 parts, Cladonia alpestris (L.) Rabenh. 8.5 parts, Fructus Liquidambaris 10 parts, Rhizoma Arundinis Donacis 10 parts, Fructus Actinidiae Argutae 6 parts, Pollen Typhae 9 parts, Flos Capsellae 10.5 parts, Semen Alpiniae Katsumadai 4.5 parts.
The preparation method for the treatment of leukemic prescription powder is:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1.5 hours, sucking filtration, merge extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug are pulverized 300 mesh sieves together, made medicated powder, medicated powder stirring and evenly mixing made with step (4), then added adjuvant, sterilizing, obtain powder.
test example 1gained of the present invention treats the clinical practice of leukemic prescription (embodiment 5):
In October ,-2014 in February, 2013,220 routine patients are filtered out, wherein women 102 example, male 118 example in 6 inpatient department leukaemics, age 12-60 year, mean age (38.4 ± 4.2) year, wherein acute lymphoblastic leukemia 68 example, acute nonlymphocytic leukemia 123 example, chronic myelocytic leukemia 29 example, all patients all check and meet before treating, hemoglobin: 47-100g/L, leukocyte count: (1.3-97.6) × 10
9/ L, platelet: (11-317) × 10
9/ L, the sick cell 27%-93% of bone marrow examination leukocyte.
Patient is divided into two groups at random, experimental group 120 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Matched group adopts basic chemotherapeutic regimen, anxious leukemia of drenching adopts the scheme such as VP, VAP, VAMP or VDLP, CEP, NA with patient: the anxious scheme such as non-pouring leukemia HA, HAA, HAE, DA, NA, FA or IA, experimental group is on the basis of matched group, take products obtained therefrom of the present invention, every day takes twice, each 3-7g(adjusts to some extent depending on concrete condition), 21 days courses for the treatment of, treat four courses for the treatment of continuously.Treatments period carries out Continuous Observation to two groups of patients, the changes such as record symptom, sign, hemogram, bone marrow smear, stool routine examination, urine routine, hepatic and renal function and electrocardiogram.
The criterion of curative effect situation is passed judgment on relevant criterion according to Ministry of Public Health about diagnosis of hematological diseases and curative effect and is formulated: complete incidence graph: (1) is clinical in the sings and symptoms caused by leukemiacell infiltration, and life is normal or close normal.(2) hemogram: Hb>=100g/L (man), or>=90g/L (female and child), neutrophilic granulocyte absolute value>=1.5 × 10
9/ L, platelet 100 × 10
9/ L.Peripheral blood leukemia divides apoplexy due to endogenous wind without leukaemia.(3) bone marrow smear: myeloblast I type+II type (original monocytic+inmature mononuclear cell or primitive lymphoid+PROLYMPHOCYTIC)≤5%, erythrocyte and megakaryocytic series normal; Partial rcsponse: bone marrow myeloblast I type+II type (original monocytic+inmature mononuclear cell or primitive lymphoid+PROLYMPHOCYTIC) > 5% and≤20%; Or have one not reach complete incidence graph standard person in clinical, hemogram item; Do not alleviate: clinical, hemogram and bone marrow smear three all do not reach complete incidence graph standard.Result is as shown in table 1.
Total effective rate=(complete incidence graph+partial rcsponse)/total number of cases × 100%
Table 1 a liang group patient treatment outcome compare (example/%)
In experimental group, complete remission rate is 41.6%, partial rcsponse rate is 54.2%, experimental group total effective rate is 95.8%, in matched group, and complete remission rate is 21.0%, partial rcsponse rate is 56.0%, matched group total effective rate is that 77.0%, two groups of results are compared known, and experimental group therapeutic effect is obviously better than matched group.Have 3 examples to occur recurrence in experimental group complete incidence graph patient, the above person of 5-year Survival reaches 46.0%, and have 6 examples to occur recurrence in matched group complete incidence graph patient, the above person of 5-year Survival reaches 23.8%.
Radix Polygalae in prescription of the present invention can be calmed the nerves Fructus Alpiniae Oxyphyllae, and Herba Rubiae Yunnanensis can be enriched blood and be invigorated blood circulation, and Herba Schizonepetae can be induced sweat loose wind, Flos Camelliae Japonicae can restrain removing heat from blood, and Semen Caesalpiniae Minacis can invigorating the spleen to arrest diarrhea, and meter Tuan Hua can be inducing diuresis and reducing edema, Changuienia amoena Chien can clearing away heat and cooling blood, and Cladonia alpestris (L.) Rabenh. can regulating menstruation, hemostasis, and Fructus Liquidambaris can dispelling, collateral-activating, Rhizoma Arundinis Donacis can clearing away heat and promoting diuresis, and Fructus Actinidiae Argutae can nourishing YIN and clearing away heat, and Pollen Typhae can hemostasia and dissipation blood stasis, Flos Capsellae can clearing away heat-damp and promoting diuresis, Semen Alpiniae Katsumadai can warming middle-JIAO to promote flow of QI, and several kinds of Chinese medicinal materials is share, and can play supplementing QI and nourishing YIN, effect such as to invigorate blood circulation of enriching blood.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat leukemic prescription, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Polygalae 6-10, Herba Rubiae Yunnanensis 8-13, Herba Schizonepetae 5-9, Flos Camelliae Japonicae 7-12, Semen Caesalpiniae Minacis 6-13, meter Tuan Hua 8-14, Changuienia amoena Chien 4-10, Cladonia alpestris (L.) Rabenh. 6-11, Fructus Liquidambaris 8-12, Rhizoma Arundinis Donacis 7-13, Fructus Actinidiae Argutae 3-9, Pollen Typhae 7-11, Flos Capsellae 9-12, Semen Alpiniae Katsumadai 3-6.
2. the leukemic prescription for the treatment of as claimed in claim 1, it is characterized in that, Radix Polygalae 7-9, Herba Rubiae Yunnanensis 9-12, Herba Schizonepetae 6-8, Flos Camelliae Japonicae 9-10, Semen Caesalpiniae Minacis 8-11, meter Tuan Hua 10-12, Changuienia amoena Chien 6-8, Cladonia alpestris (L.) Rabenh. 7-10, Fructus Liquidambaris 9-11, Rhizoma Arundinis Donacis 9-11, Fructus Actinidiae Argutae 4-8, Pollen Typhae 8-10, Flos Capsellae 10-11, Semen Alpiniae Katsumadai 4-5 is (preferred, Radix Polygalae 8, Herba Rubiae Yunnanensis 10.5, Herba Schizonepetae 7, Flos Camelliae Japonicae 9.5, Semen Caesalpiniae Minacis 9.5, meter Tuan Hua 11, Changuienia amoena Chien 7, Cladonia alpestris (L.) Rabenh. 8.5, Fructus Liquidambaris 10, Rhizoma Arundinis Donacis 10, Fructus Actinidiae Argutae 6, Pollen Typhae 9, Flos Capsellae 10.5, Semen Alpiniae Katsumadai 4.5).
3. the preparation method of the powder of the leukemic prescription for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug are pulverized and sieved together, make medicated powder, medicated powder stirring and evenly mixing made with step (4), then add adjuvant, sterilizing, obtain powder.
4. the preparation method of the leukemic prescription powder for the treatment of as claimed in claim 3, is characterized in that, step (5) pulverized 200-400 mesh sieve (preferred, to pulverize 300 mesh sieves).
5. the preparation method of the tablet of the leukemic prescription for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, make medicated powder, load in penetrating bag, decoct with water 3 times, each big fire is boiled rear little fire and is continued to decoct 20-28 minute (preferred, little fire continues to decoct 22-26 minute; Be more preferably, little fire continues to decoct 24 minutes), collecting by filtration filtrate, merges three gained filtrates, concentrated, lyophilization, make medicated powder, and mix with step (4) made medicated powder, add 10% starch slurry and cane sugar powder soft material, granulate, dry, granulate, adds Pulvis Talci, tabletting, and sterilizing obtains tablet.
6. the preparation method of the leukemic prescription tablet for the treatment of as claimed in claim 5, is characterized in that, doubly (preferred, the 6-7 that each added water amount is the quality of boiled crude drug doubly for the 5-8 that the amount that step (5) is each added water is the quality of boiled crude drug; Be more preferably, 6.5 times of the quality that each added water amount is boiled crude drug).
7. the preparation method of the capsule of the leukemic prescription for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis were pulverized 80 mesh sieves, by reflux, extract, at 70% ethanol 100 DEG C twice (institute's lixiviate crude drug and 70% ethanol are by quality and volume ratio 1:5g/mL), each reflux, extract, 1-2 hour (preferred, reflux, extract, 1.5 hours), sucking filtration, merges extracted twice liquid, recycling design, obtained thick paste, dry, pulverize and make medicated powder;
(5) Pollen Typhae, Flos Capsellae and step (1) (2) (3) made crude drug were pulverized 80 mesh sieves together, and made medicated powder, load in penetrating bag, decoct with water 3 times (6.5 times of the quality that each added water amount is boiled crude drug), each big fire is boiled rear little fire and is continued to decoct 20-28 minute, collecting by filtration filtrate, merge three gained filtrates, concentrated, lyophilization, makes medicated powder, and mix with step (4) made medicated powder, granule processed, incapsulates, and obtains capsule.
8. the preparation method of the leukemic prescription capsule for the treatment of as claimed in claim 7, is characterized in that, step (5) little fire continues to decoct 22-26 minute (preferred, little fire continues to decoct 24 minutes).
9. the preparation method of the decoction of the leukemic prescription for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) wheat bran is placed in frying pan, has been heated to cigarette and has emerged, add Radix Polygalae and Herba Schizonepetae stir-fries, fry to crude drug surface micro-yellow time, stop heating, take out sieve and remove wheat bran, Radix Polygalae and Herba Schizonepetae section or cutting, Sucus Zingberis floods 10 minutes, and taking-up is dried;
(2) get Semen Caesalpiniae Minacis water infiltration, shell, mix placement thoroughly 30 minutes with Sucus Zingberis, then fry micro-Huang to surface with slow fire and take out, smash to pieces together with Fructus Actinidiae Argutae with Flos Camelliae Japonicae, add refined honey and water is mixed thoroughly, be placed in steamer, Steam by water bath is saturating, takes out, and dries;
(3) get Fructus Liquidambaris and Semen Alpiniae Katsumadai roguing, infiltrate 10 minutes with yellow wine, take out, be placed in pot, the pot that upper cover one bore is less, commissure yellow mud sealing, the pot of upper cover is pressed a weight, and puts a blank sheet of paper, slow fire grilling, when paper turns yellow, closes fire and cools completely, take out crude drug;
(4) together with Herba Rubiae Yunnanensis, meter Tuan Hua, Changuienia amoena Chien, Cladonia alpestris (L.) Rabenh. and Rhizoma Arundinis Donacis and step (1) (3) made crude drug, decocting in water is added, the amount added water is 6 times of boiled crude drug quality, big fire is boiled rear little fire and is boiled 30-36 minute (preferably, little fire boils 31-35 minute, be more preferably, little fire boils 33 minutes), filter, collect filtrate;
(5) Pollen Typhae, Flos Capsellae and step (2) made crude drug are pulverized and sieved together, make medicated powder, join in step (4) made filtrate and mix, sterilizing, obtains decoction.
10. the preparation method of the leukemic prescription decoction for the treatment of as claimed in claim 9, is characterized in that, step (5) was pulverized 180-260 mesh sieve and (preferably, pulverized 200-240 mesh sieve; Be more preferably, pulverized 220 mesh sieves).
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