CN103599412B - Bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat and preparation method thereof - Google Patents
Bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to one and treat the bronchitic compound traditional Chinese medicine composite of chicken infectivity throat, by following component by weight mixed preparing form: Herba Lophatheri 15-35 part, Semen Sojae Preparatum 15-35 part, Haematitum 15-35 part, Herba Visci 15-35 part, Herba Ecliptae 10-35 part, Fructus Oryzae Germinatus 10-35 part, Bombyx Batryticatus 15-25 part, Bulbus Allii Macrostemonis 15-35 part, Herba Menthae 10-40 part, Venenum Bufonis 10-25 part, Nodus Nelumbinis Rhizomatis 15-45 part, Exocarpium Citri Rubrum 10-35 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, and clinical proof has specially good effect to treatment chicken infectivity throat bronchitis.
Description
Technical field
The present invention relates to bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat and preparation method thereof, belong to field of animal, particularly one is specifically designed to bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat and preparation method thereof.
Background technology
Chicken infectivity throat bronchitis is that the one caused by chicken infectivity throat bronchitis virus is acute, the contact upper respiratory infectious disease.The chicken of various age and kind all can infect, and it is characterized in that dyspnea, cough and expectoration contain the exudate of blood sample.Visible throat when cuing open inspection, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can occur throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is herpesvirus, and virus can be survived more than 1 year in dry environments.Under cryogenic, the time-to-live is long.This disease is all poultry countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine prohibits the use.
Therefore research and develop and a kind ofly treat the bronchitic drug residue free of chicken infectivity throat, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the bronchitic compound traditional Chinese medicine composite of effective treatment chicken infectivity throat and preparation method thereof of drug residue.
For achieving the above object, implementation of the present invention is as follows: one treats the bronchitic compound traditional Chinese medicine composite of chicken infectivity throat, by following component by weight mixed preparing form: Herba Lophatheri 15-35 part, Semen Sojae Preparatum 15-35 part, Haematitum 15-35 part, Herba Visci 15-35 part, Herba Ecliptae 10-35 part, Fructus Oryzae Germinatus 10-35 part, Bombyx Batryticatus 15-25 part, Bulbus Allii Macrostemonis 15-35 part, Herba Menthae 10-40 part, Venenum Bufonis 10-25 part, Nodus Nelumbinis Rhizomatis 15-45 part, Exocarpium Citri Rubrum 10-35 part.
Described various component optimum ratio amount is: Herba Lophatheri 25 parts, Semen Sojae Preparatum 25 parts, Haematitum 25 parts, Herba Visci 25 parts, Herba Ecliptae 25 parts, Fructus Oryzae Germinatus 25 parts, Bombyx Batryticatus 20 parts, Bulbus Allii Macrostemonis 25 parts, Herba Menthae 25 parts, Venenum Bufonis 15 parts, Nodus Nelumbinis Rhizomatis 30 parts, Exocarpium Citri Rubrum 25 parts.
Treat a preparation method for the bronchitic compound traditional Chinese medicine composite of chicken infectivity throat, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Lophatheri 15-35 part, Semen Sojae Preparatum 15-35 part, Haematitum 15-35 part, Herba Visci 15-35 part, Herba Ecliptae 10-35 part, Fructus Oryzae Germinatus 10-35 part by weight, mix 5-10 minute to even;
(3) take Bombyx Batryticatus 15-25 part, Bulbus Allii Macrostemonis 15-35 part, Herba Menthae 10-40 part, Venenum Bufonis 10-25 part, Nodus Nelumbinis Rhizomatis 15-45 part, Exocarpium Citri Rubrum 10-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Herba Lophatheri: sweet, light, cold, GUIXIN, stomach, small intestine meridian, have the function of heat clearing away, diuresis; Cure mainly that heat in the heart tongue boil, short urination are red, hematuria etc.
Semen Sojae Preparatum: pungent, bitter, cool, attaches to the lung and stomach meridians, and has the function of heat clearing away of inducing sweat; Cure mainly fever caused by exogenous pathogens, restlessness etc.
Haematitum: bitter, cold, GUIXIN, Liver Channel, have the function of suppressing the hyperactive liver and subsiding YANG, important city sending down the abnormal ascending QI, cooling blood for hemostasis; Cure mainly singultus, cough with asthma, vomiting, epistaxis, haematemesis, discharging fresh blood stool, metrorrhagia etc.
Herba Visci: bitter, flat, returns liver, kidney channel, has the function of wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, nourishing blood and preventing abortion; Cure mainly that rheumatic arthralgia, waist are unable, frequent fetal movement etc.
Herba Ecliptae: sweet, sour, cold, returns kidney, Liver Channel, has the function of cooling blood for hemostasis, nourishing the liver and kidney; Cure mainly YinXuXueRe, epistaxis, hematuria, have blood in stool, dysentery, metrorrhagia, waist hip are unable.
Fructus Oryzae Germinatus: sweet, warm, returns spleen, stomach warp, have help digestion and in, the function of spleen benefiting and stimulating the appetite; Cure mainly that food stagnation does not disappear, abdominal distention, weakness of the spleen and stomach etc.
Bombyx Batryticatus: become, pungent, flat, return lung, liver, stomach warp, there is the function of endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses; Cure mainly liver-wind tic, tetanus, sore throat, skin pruritus etc.
Bulbus Allii Macrostemonis: acrid, bitter, warm, returns lung, stomach, large intestine channel, has the function of activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving; Cure mainly the thoracic obstruction, dyspeptic abdominal distention, dysentery etc.
Herba Menthae: pungent, cool, returns lung, Liver Channel, has the function of wind-dispelling heat-dissipating, the clear sharp head, sore-throat relieving, rash; Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, rubella etc.
Venenum Bufonis: pungent, warm, GUIXIN warp, has removing toxic substances, pain relieving, the function of having one's ideas straightened out; Cure mainly skin ulcer yellow furunculosis, laryngopharynx swelling and pain, heatstroke coma etc.
Nodus Nelumbinis Rhizomatis: sweet, puckery, flat, returns lung, stomach, Liver Channel, has the function of astringing to arrest bleeding, blood stasis dispelling; Cure mainly have blood in stool, hematuria, epistaxis, hemoptysis, metrorrhagia etc.
Exocarpium Citri Rubrum: acrid, bitter, warm, returns lung, spleen channel, has the function of drying dampness to eliminate phlegm, regulating the flow of QI to ease the stomach; Cure mainly cough with copious phlegm, food stagnation, abdominal distention etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the bronchitic clinical symptoms of chicken infectivity throat and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition no drug residue, have no drug resistance, cost is low, and draw materials wide, micronizing, bioavailability are high, can also can drink water by spice, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment chicken infectivity throat bronchitis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
One treats bronchitic compound traditional Chinese medicine composite of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Lophatheri 150 parts, Semen Sojae Preparatum 150 parts, Haematitum 150 parts, Herba Visci 150 parts, Herba Ecliptae 100 parts, Fructus Oryzae Germinatus 100 parts by weight, mix 5-10 minute to even;
(3) take Bombyx Batryticatus 150 parts, Bulbus Allii Macrostemonis 150 parts, Herba Menthae 100 parts, Venenum Bufonis 100 parts, Nodus Nelumbinis Rhizomatis 150 parts, Exocarpium Citri Rubrum 100 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
One treats bronchitic compound traditional Chinese medicine composite of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Lophatheri 250 parts, Semen Sojae Preparatum 250 parts, Haematitum 250 parts, Herba Visci 250 parts, Herba Ecliptae 250 parts, Fructus Oryzae Germinatus 250 parts by weight, mix 5-10 minute to even;
(3) take Bombyx Batryticatus 200 parts, Bulbus Allii Macrostemonis 250 parts, Herba Menthae 250 parts, Venenum Bufonis 150 parts, Nodus Nelumbinis Rhizomatis 300 parts, Exocarpium Citri Rubrum 250 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
One treats bronchitic compound traditional Chinese medicine composite of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Lophatheri 350 parts, Semen Sojae Preparatum 350 parts, Haematitum 350 parts, Herba Visci 350 parts, Herba Ecliptae 350 parts, Fructus Oryzae Germinatus 350 parts by weight, mix 5-10 minute to even;
(3) take Bombyx Batryticatus 250 parts, Bulbus Allii Macrostemonis 350 parts, Herba Menthae 400 parts, Venenum Bufonis 250 parts, Nodus Nelumbinis Rhizomatis 450 parts, Exocarpium Citri Rubrum 350 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 25 ages in days, body weight at 1.1kg-1.2kg, and Laboratory Diagnosed is the bronchitic ill broiler of chicken infectivity throat.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 100,3 groups of feeding environments are identical, and experimental period carries out 7 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill poultry of feeding etc., day dose be: by the every 100g of the present invention, spice 220kg feeds or the 400kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Following table is the result at the end of experiment.
Efficacy assessment standard:
Cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, and breathe normal, body temperature is normal.Cut open the histoorgans such as detector tube, bronchus, larynx, lungs normal, test in laboratory has no pathogenic microorganism chicken infectivity throat bronchitis virus.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is that the present invention and other medicines are treated the bronchitic Field information situation of chicken infectivity throat and contrasted:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 33 | 5 | 62 |
| II | HOUYANJING SAN group | 11 | 77 | 12 |
| III | Chinese medicine composition group of the present invention | 7 | 87 | 6 |
This clinical effectiveness statistical analysis, present composition treatment group and HOUYANJING SAN group in cure rate compared with difference extremely significantly (P<0.01).
Safety testing:
Choose the healthy broiler 60 of 20 ages in days, according to the made compositions recommended dose of the embodiment of the present invention 25 times of spices or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of bronchitic compound traditional Chinese medicine composite of this treatment chicken infectivity throat and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a chicken infectivity throat bronchitic compound traditional Chinese medicine composite, it is characterized in that by following component by weight mixed preparing form: Herba Lophatheri 15-35 part, Semen Sojae Preparatum 15-35 part, Haematitum 15-35 part, Herba Visci 15-35 part, Herba Ecliptae 10-35 part, Fructus Oryzae Germinatus 10-35 part, Bombyx Batryticatus 15-25 part, Bulbus Allii Macrostemonis 15-35 part, Herba Menthae 10-40 part, Venenum Bufonis 10-25 part, Nodus Nelumbinis Rhizomatis 15-45 part, Exocarpium Citri Rubrum 10-35 part.
2. the bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat according to claim 1, is characterized in that described various component optimum ratio amount is: Herba Lophatheri 25 parts, Semen Sojae Preparatum 25 parts, Haematitum 25 parts, Herba Visci 25 parts, Herba Ecliptae 25 parts, Fructus Oryzae Germinatus 25 parts, Bombyx Batryticatus 20 parts, Bulbus Allii Macrostemonis 25 parts, Herba Menthae 25 parts, Venenum Bufonis 15 parts, Nodus Nelumbinis Rhizomatis 30 parts, Exocarpium Citri Rubrum 25 parts.
3. a preparation method for the bronchitic compound traditional Chinese medicine composite for the treatment of chicken infectivity throat according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Lophatheri 15-35 part, Semen Sojae Preparatum 15-35 part, Haematitum 15-35 part, Herba Visci 15-35 part, Herba Ecliptae 10-35 part, Fructus Oryzae Germinatus 10-35 part by weight, mix 5-10 minute to even;
(3) take Bombyx Batryticatus 15-25 part, Bulbus Allii Macrostemonis 15-35 part, Herba Menthae 10-40 part, Venenum Bufonis 10-25 part, Nodus Nelumbinis Rhizomatis 15-45 part, Exocarpium Citri Rubrum 10-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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|---|---|---|---|---|
| CN101732600A (en) * | 2008-11-06 | 2010-06-16 | 吕秋红 | Medicament for treating tracheitis |
| CN101732596A (en) * | 2008-11-24 | 2010-06-16 | 郑水灿 | Medicament for treating tracheitis |
| CN101647968B (en) * | 2009-08-31 | 2011-06-15 | 李敬云 | Traditional Chinese medicine composition for treating chicken infectious bronchitis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732600A (en) * | 2008-11-06 | 2010-06-16 | 吕秋红 | Medicament for treating tracheitis |
| CN101732596A (en) * | 2008-11-24 | 2010-06-16 | 郑水灿 | Medicament for treating tracheitis |
| CN101647968B (en) * | 2009-08-31 | 2011-06-15 | 李敬云 | Traditional Chinese medicine composition for treating chicken infectious bronchitis |
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| CN103599412A (en) | 2014-02-26 |
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Effective date of registration: 20180511 Address after: 401520 Buddha pearl village, Longxing Town, Chongqing City, five Patentee after: CHONGQING WANYUAN EGG FOOD CO.,LTD. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: QINGDAO LVMAN BIOLOGICAL ENGINEERING Co.,Ltd. |
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Denomination of invention: Compound Chinese medicine composition and preparation method for treating infectious laryngobronchitis in chickens Granted publication date: 20160224 Pledgee: Chongqing Branch of China Everbright Bank Co.,Ltd. Pledgor: CHONGQING WANYUAN EGG FOOD CO.,LTD. Registration number: Y2024500000033 |