CN103859168B - The anti-avian influenza feed addictive of a kind of large-scale ecological poultry and preparation thereof, using method - Google Patents
The anti-avian influenza feed addictive of a kind of large-scale ecological poultry and preparation thereof, using method Download PDFInfo
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- CN103859168B CN103859168B CN201410134154.XA CN201410134154A CN103859168B CN 103859168 B CN103859168 B CN 103859168B CN 201410134154 A CN201410134154 A CN 201410134154A CN 103859168 B CN103859168 B CN 103859168B
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- hypericum perforatum
- avian influenza
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Abstract
The present invention relates to a kind of large-scale ecological poultry anti-avian influenza feed addictive of Be very effective; be prepared from by the raw material of following masses number: Japanese Metaplexis Pericarp 50-120 part, hypericum perforatum thick material 20-50 part, Radix Astragali 20-30 part; honeysuckle 15-30 part, Radix Isatidis 20-30 part.The invention still further relates to the preparation method of above-mentioned feed addictive: get above-mentioned raw materials respectively, be ground into fine powder, cross 100 mesh sieves, mixing.The present invention also relates to the using method of above-mentioned feed addictive: by the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by the mass ratio of 5-10:1, puts into mixer and stirs 120-150 minute, takes out, stirs into pasty state for chicken feed with water.Adopt anti-avian influenza feed addictive feeding chicken of the present invention, easy and simple to handle, control bird flu Be very effective.
Description
Technical field
The present invention relates to field of feed additive technology, especially bird feed additive technical field.
Background technology
At present; in feeding chicken in largely scale process; " two high one low " problem, particularly epidemic disease risk of ubiquitous low quality (product quality), high investment (aquaculture cost input), excessive risk (epidemic disease risk) is the important bottleneck of puzzlement China chicken aquaculture industry development always.
In recent years, along with improving constantly of living standards of the people, the quality of consumer to chicken is had higher requirement.Due in feeding chicken in largely scale process for solving epidemic disease excessive risk problem, and use antibiotic in a large number and feed addictive is residual and accumulation, cause a series of food security and human health problems, impel people to start to pay close attention to the mode of raising chicken on a small scale scattered.Raise chicken scattered owing to belonging to pure natural feed or semi-artificial raising; the chemical substance such as antibiotic, hormone is not added in feed; and chicken is naturally being put in a suitable place to breed in process; automatically the wild worm of weeds etc. of occurring in nature is taken food; chicken meat quality outclass the chicken of complete artificial feeding in large-scale cultivation, and this is a kind of ecologic breeding mode of producing green non-pollution food.But apparent, this ecological poultry mode, the drawback that what bring is small scale, growth cycle is long, output is few, benefit is low, both cannot create a large amount of economic benefits, also cannot meet increasing consumer demand.Meanwhile, although it is more less than batch production disease epidemic disease of raising chickens to raise chicken scattered, but still can the state of an illness be there is and the epidemic disease etc. that spreads disease, finally still need to use antibiotic, cause antibiotic to accumulate, affect food security.Therefore, increasing sight is invested how to reduce and is even avoided using antibiotic by people, carries out large-scale ecological poultry.
The Chinese medicinal herb chicken feed of green non-pollution has just become more and more researcher and breeding enterprise to pay close attention to target.
Japanese Metaplexis Pericarp is the shell of Asclepiadaceae plant trailing plants Japonica Metaplexis japonica (Thunb.) Makino.The traditional Chinese medical science is thought, its energy clearing lung and eliminating phlegm, and loose stasis of blood hemostasis, cures mainly coughing with a lot of sputum, asthma, pertussis etc.Main product is with in Jiangsu-zhejiang Shanghai Area one, markets one's own products more.Report not about the effect of Japanese Metaplexis Pericarp anti-avian influenza in prior art.The present inventor through a large amount of screening tests, Late Cambrian its there is stronger anti-avian influenza effect.
A large amount of research practice finds, Chinese medicine compound prescription has combination advantage in preventing and curing diseases, the curative effect of medication after compound compatibility be often greater than simply adding of simple curative effect and.
Hypericum perforatum is the dry herb of Garcinia maingayii hypericum perforatum Hypericum perforatum L..The extract of existing pharmacology and clinical trial certificate hypericum perforatum effectively can be used for the treatment of depressed and anxiety class psychosis, has been used for the treatment of clinically slightly, moderate depressive patients in the U.S. and European Union's Countries.In addition, its extract also tool is antiviral and strengthen immunologic function, and research finds that the killing rate of hypericin to H 5 N 1 avian influenza and H9N2 subtype virus in extract can reach 100%.But hypericum perforatum traditional extraction technique method will use multi-solvents and acid-base class chemical reagent, part improving technology needs to add various chemical stabilizer, not only cost is high, complex process, and containing the chemical substance that part is harmful to chicken in crude extract, chicken cannot directly be eaten.Primary medicinal component comprises the materials such as anthrone class (hypericin, pseudohypericin, different hypericin, former hypericin), phloroglucinol derivatives (between hyperforine, acyl group this triphenol), flavonoids (Quercetin, Hyperoside, rutin, amentoflavone etc.), mountain pass ketone and phenolic acid class.Tool antidepression, antiviral and enhancing immunologic function, the killing rate of its extract hypericin to H 5 N 1 avian influenza and H9N2 subtype virus can reach 100%.The traditional Chinese medical science is thought, its tool is clearing heat and detoxicating, astringing to arrest bleeding, effect of dampness removing.Cure mainly spitting of blood, spit blood, discharging fresh blood stool, traumatism and bleeding, treating rheumatic ostealgia, the raw sore of mouth and nose, pyogenic infections, burn.
The Radix Astragali is the dry root of legume astragalus mongolicus Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge..Chemical composition: containing sucrose, glucuronic acid, astragalus polyose A, B, C, D, lymphatic temperament, several amino acids, bitter principle, astragaloside, choline, folic acid, flavane compound and containing the various trace elements such as selenium, silicon, zinc, cobalt, copper, molybdenum.Have and have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.
Honeysuckle is dry flower or the first flower opened of band of caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicerahypoglauca Miq. or hair style honeysuckle Lonicera dasystyla Rehd..Chemical composition: chlorogenic acid, isochlorogenic acid, sweet-scented osmanthus oxalic acid, cyanidenon-glucoside, lonicerin, saponin(e, waves oil, inositol, tannin, iridoid glycoside, sweroside, loganin, logaric acid, helexin aglucon, oleanolic acid; The functional components such as disacoside B, linalool, honeysuckle alcohol, geraniol, bata-phenethyl alcohol, phenmethylol, isodigeranyl flower alcohol, alpha-terpineol, Eugenol.The traditional Chinese medical science thinks that it is cold in nature, and taste is sweet, slightly tart flavour, has clearing heat and detoxicating, cool blood, clearing and activating the channels and collaterals effect.
Radix Isatidis is the dry root of cruciferae isatis Isatis indigotica Fort..Chemical composition: indigo glucoside, isatin, indigo, woaded blue glucoside B, uridine, uracil, hypoxanthine, salicylic acid, Daucosterol, cupreol, Radix Isatidis B prime, C prime and D prime, and the functional materials such as vegetable protein, resin-like thing, carbohydrate, sinigrin, several amino acids and trace element.The traditional Chinese medical science is thought and its nature and flavor bitter cold is cured mainly febrile virulent maculae; High heat headache; Major part pestilence; Tongue is secretly dark reddish purple, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle swells; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma tells nosebleed, and pharynx is swollen, pinkeye, sore rash; Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis etc. can be prevented and treated.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of anti-avian influenza feed addictive used in large-scale ecological poultry process, makes the effect of this feed addictive control chicken infection bird flu remarkable.
Another technical problem to be solved by this invention provides a kind of preparation method of aforementioned anti-avian influenza feed addictive, makes that its cost is low, convenient operation.
Technical problem to be solved by this invention is also the using method providing a kind of aforementioned anti-avian influenza feed addictive, makes playing a role of its economical and efficient.
In order to solve the problems of the technologies described above, the applicant has carried out the test of a large amount of raw material screening, and Late Cambrian Japanese Metaplexis Pericarp has a stronger anti-avian influenza effect.In order to give full play to the combination advantage of Chinese medicine compound prescription anti-avian influenza, the applicant, on the basis that drug matching is studied, proposes following technical proposal:
An anti-avian influenza feed addictive for large-scale ecological poultry, is characterized in that described feed addictive is prepared from by the raw material of following masses number:
Japanese Metaplexis Pericarp 50-120 part, hypericum perforatum thick material 20-50 part, Radix Astragali 20-30 part, honeysuckle 15-30 part, Radix Isatidis 20-30 part;
The thick material system of described hypericum perforatum take hypericum perforatum as raw material, is prepared from following method:
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 60-120g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2-3 hour, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40-180ml in every 100g hypericum perforatum meal, at 20-45 DEG C of condition bottom fermentation 12-25 days, obtain hypericum perforatum fermentation meal;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
The formula of described feed addictive is preferably:
Japanese Metaplexis Pericarp 100 parts, the thick material of hypericum perforatum 30 parts, the Radix Astragali 25 parts, honeysuckle 20 parts, Radix Isatidis 25 parts.
The technological parameter of preparation activated yeast mixture is preferably: by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours.
The technological parameter preparing hypericum perforatum fermentation meal was preferably: the ratio adding activated yeast mixture 100ml in every 100g hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days.
The preparation method of the anti-avian influenza feed addictive of described a kind of large-scale ecological poultry; it is characterized in that described method is as follows: get Japanese Metaplexis Pericarp, the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis respectively; be ground into fine powder; cross 100 mesh sieves; by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
The using method of the anti-avian influenza feed addictive of described a kind of large-scale ecological poultry, it is characterized in that described method is as follows: by the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by the mass ratio of 5-10:1, put into mixer and stir 120-150 minute, take out, stir into pasty state for chicken feed with water; Also, after can drying, moistureproof airtight package is preserved, for subsequent use.
During use, the basal diet feed of described chicken and the mass ratio of anti-avian influenza feed addictive are preferably 8:1.
Adopt anti-avian influenza feed addictive feeding chicken of the present invention, easy and simple to handle, control bird flu Be very effective.Its Advantageous Effects can be proved by following test.
The feed addictive of test example 1 different formulations is to the preventive and therapeutic effect infecting bird flu chicken
1, test material:
Feed addictive of the present invention, prepares by embodiment 11 method and uses.
Single Japanese Metaplexis Pericarp feed addictive, gets Japanese Metaplexis Pericarp, pulverizes, and crosses 100 mesh sieves, to obtain final product.Using method is with embodiment 11.
Remove Japanese Metaplexis Pericarp feed addictive, except (namely only not containing the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis in formula) containing except Japanese Metaplexis Pericarp in formula, all the other methods of preparation and use are with embodiment 11.
Basal diet feed, self-control, often organizes the basal feed that test chicken all gives same specification.
Amantadine hydrochloride is purchased from Dongbei Pharmaceutical General Factory.
8 week age, SPF chicken was provided by Harbin Veterinary Medicine Inst., China Academy of Agriculture's Experimental Animal Center.
H5N1 subtype avian influenza virus is provided by animal influenza emphasis open laboratory of the Ministry of Agriculture.
2, method
Test is divided into 6 groups, and the Ith group is Normal group, totally 10 SPF chickens.Often daily give not containing the basal diet feed of any additive.
IIth group is model group.Totally 45 SPF chickens.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Often daily give not containing the basal diet feed of any additive.
IIIth group is feed group of the present invention, totally 38 SPF chickens.Attacking the front diet feed being added with feed addictive of the present invention for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, be all added with the diet feed of feed addictive of the present invention every day.
IVth group is amantadine control group, totally 38 SPF chickens.Attacking the front diet feed being added with amantadine hydrochloride for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, be all added with the diet feed of amantadine hydrochloride every day.
Vth group is single Japanese Metaplexis Pericarp group, totally 38 SPF chickens.Attacking the front diet feed being added with single Japanese Metaplexis Pericarp feed addictive for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, all give the diet feed of single Japanese Metaplexis Pericarp feed addictive every day.
VIth group is Japanese Metaplexis Pericarp group, totally 38 SPF chickens.Attacking the front diet feed being added with Japanese Metaplexis Pericarp feed addictive for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, all remove the diet feed of Japanese Metaplexis Pericarp feed addictive every day.
Continuous Observation 14 days from attacking poison, observes and records the death toll of chicken, then calculating protective rate (protective rate=survival number/total * 100%).
Data statistical approach: the comparison of two sample rates adopts Chi-square Test.
3, result
Result of the test is in table 1, and result shows, the protective rate of feed group of the present invention reaches 63.16%, is greater than 60.53% of positive controls-amantadine group; Each administration group is compared with model group, and the equal tool of its difference is very significant (p<0.01); Feed group of the present invention and single Japanese Metaplexis Pericarp group and go compared with Japanese Metaplexis Pericarp group, the difference of its protective rate has significant (p<0.05).
The above results shows, the Be very effective of Chinese medicine compound prescription feed addictive control bird flu of the present invention, uses the successful of the present composition be better than alone Japanese Metaplexis Pericarp or use hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis composition.
The feed addictive of table 1 different formulations is to the preventive and therapeutic effect infecting bird flu chicken
| Group | Survival number | Death toll | Protective rate |
| Normal group | 10 | 0 | 100.00% |
| Model group | 3 | 42 | 6.67% |
| Feed group of the present invention | 24 | 14 | 63.16%** |
| Amantadine group | 23 | 15 | 60.53%** |
| Single Japanese Metaplexis Pericarp group | 14 | 24 | 36.84%**，△ |
| Go Japanese Metaplexis Pericarp group | 13 | 25 | 34.21%**，△ |
Note: compared with model group, * * p<0.01; Compared with feed group of the present invention, △ p<0.05.
Test example 2 feed addictive of the present invention is on the impact of SPF chicken immuological function
1, test material:
Feed addictive of the present invention, prepares by embodiment 11 method and uses.
Basal diet feed, self-control, often organizes the basal feed that test chicken all gives same specification.
SPF chicken is provided by Harbin Veterinary Medicine Inst., China Academy of Agriculture's Experimental Animal Center.
2, method
1 age in days, 40 SPF chickens are divided into 2 groups at random, often organize 20.First group is feed group of the present invention, is added with the diet feed of feed addictive of the present invention every day.Other one group is blank group, gives every day not containing the diet feed of any additive.Randomly draw normotrophic 10 chickens at 14 ages in days, dissect according to a conventional method, be separated and measure the Immune Organs Index (immune organ weight is tried to achieve divided by corresponding chicken body weight) of thymus gland.Understand immune organ growth and development situation.At 21 ages in days, random choose 5 from 4 groups of test chickens, heart adopts 2ml heparin anti-coagulating.FAC measures the content of CD3, CD4.
Data and statistics: data with
represent, carry out single factor test variance with SPSS11.0 software and carry out significance,statistical analysis.
3, result
3.1 feed addictives of the present invention are on the impact of Immune Organs Index
The results are shown in Table 2, result shows that the thymus index of feed group of the present invention is obviously better than blank group, and its difference has statistical significance (p<0.05).
Table 2 feed addictive of the present invention is on the impact of Immune Organs Index
| Group | Thymus index (%) |
| Feed group of the present invention | 0.65±0.12** |
| Blank group | 0.48±0.15 |
Note: compared with blank group, * p<0.05, * * p<0.01.
The impact of CD3+, CD4+T lymphocyte content in 3.2 feed addictive Peripheral Bloods of the present invention
The results are shown in Table 3, result shows that in the peripheral blood of feed group of the present invention, CD3+, CD4+T lymphocyte content is obviously better than blank group, and its difference has statistical significance (p<0.05,0.01).
The impact of CD3+, CD4+T lymphocyte content in table 3 feed addictive Peripheral Blood of the present invention
| Group | CD3+（%） | CD4+ |
| Feed group of the present invention | 54.4±7.6** | 31.6±7.3* |
| Blank group | 32.7±9.2 | 23.5±6.7 |
Note: compared with blank group, * p<0.05, * * p<0.01.
In sum, feed addictive of the present invention can significantly improve the immunity of chicken, control bird flu Be very effective.
In order to better set forth technical scheme of the present invention, below in conjunction with detailed description of the invention, the present invention is further illustrated, but protection domain of the presently claimed invention is not limited to the following example.
Detailed description of the invention
Embodiment 1
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 60g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2 hours, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 12 days, obtain hypericum perforatum fermentation meal;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 50 parts, the thick material of hypericum perforatum 50 parts, the Radix Astragali 30 parts, honeysuckle 30 parts, Radix Isatidis 30 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 5:1 mass ratio, puts into mixer and stirs 120 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 50.00%, and prevention effect is remarkable.
Embodiment 2
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 120g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 3 hours, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 180ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 25 days, obtain hypericum perforatum fermentation meal;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 120 parts, the thick material of hypericum perforatum 20 parts, the Radix Astragali 20 parts, honeysuckle 15 parts, Radix Isatidis 20 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 10:1 mass ratio, puts into mixer and stirs 150 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 57.89%, and prevention effect is remarkable.
Embodiment 3
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 120 parts, the thick material of hypericum perforatum 20 parts, the Radix Astragali 30 parts, honeysuckle 30 parts, Radix Isatidis 30 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 55.26%, and prevention effect is remarkable.
Embodiment 4
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 50 parts, the thick material of hypericum perforatum 50 parts, the Radix Astragali 20 parts, honeysuckle 15 parts, Radix Isatidis 20 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 52.63%, and prevention effect is remarkable.
Embodiment 5
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 120 parts, the thick material of hypericum perforatum 50 parts, the Radix Astragali 20 parts, honeysuckle 30 parts, Radix Isatidis 30 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 55.26%, and prevention effect is remarkable.
Embodiment 6
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 50 parts, the thick material of hypericum perforatum 20 parts, the Radix Astragali 30 parts, honeysuckle 15 parts, Radix Isatidis 20 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 52.63%, and prevention effect is remarkable.
Embodiment 7
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 120 parts, the thick material of hypericum perforatum 50 parts, the Radix Astragali 30 parts, honeysuckle 15 parts, Radix Isatidis 30 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 55.26%, and prevention effect is remarkable.
Embodiment 8
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 50 parts, the thick material of hypericum perforatum 20 parts, the Radix Astragali 20 parts, honeysuckle 30 parts, Radix Isatidis 20 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 57.89%, and prevention effect is remarkable.
Embodiment 9
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 120 parts, the thick material of hypericum perforatum 50 parts, the Radix Astragali 50 parts, honeysuckle 30 parts, Radix Isatidis 20 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 60.53%, and prevention effect is remarkable.
Embodiment 10
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 50 parts, the thick material of hypericum perforatum 20 parts, the Radix Astragali 20 parts, honeysuckle 15 parts, Radix Isatidis 30 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the protective rate of the present embodiment additive to infection bird flu chicken is 55.26%, and prevention effect is remarkable.
Embodiment 11
1, the preparation of the thick material of hypericum perforatum
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 80g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours;
(3) ratio of activated yeast mixture 100ml is added in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take Japanese Metaplexis Pericarp 100 parts, the thick material of hypericum perforatum 30 parts, the Radix Astragali 25 parts, honeysuckle 20 parts, Radix Isatidis 25 parts by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, take out, stir into pasty state for chicken feed with water; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
See test example 1,2.
Claims (7)
1. an anti-avian influenza feed addictive for large-scale ecological poultry, is characterized in that described feed addictive is prepared from by the raw material of following masses number:
Japanese Metaplexis Pericarp 50-120 part, hypericum perforatum thick material 20-50 part, Radix Astragali 20-30 part, honeysuckle 15-30 part, Radix Isatidis 20-30 part;
The thick material system of described hypericum perforatum take hypericum perforatum as primary raw material, is prepared from following method:
(1) dry for hypericum perforatum herb pulverizer is ground into meal;
(2) by dusty yeast 10g, the ratio of edible rice flour 60-120g, water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2-3 hour, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40-180ml in every 100g hypericum perforatum meal, at 20-45 DEG C of condition bottom fermentation 12-25 days, obtain hypericum perforatum fermentation meal;
(4) meal that fermented by hypericum perforatum is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2. the anti-avian influenza feed addictive of a kind of large-scale ecological poultry according to claim 1, is characterized in that described feed addictive is prepared from by the raw material of following masses number:
Japanese Metaplexis Pericarp 100 parts, the thick material of hypericum perforatum 30 parts, the Radix Astragali 25 parts, honeysuckle 20 parts, Radix Isatidis 25 parts.
3. the anti-avian influenza feed addictive of a kind of large-scale ecological poultry according to claim 1; it is characterized in that described activated yeast mixture is prepared with following method: by dusty yeast 10g; edible rice flour 80g; the ratio of water 1000ml carries out fermentation raw material preparation, after put into 25-37 DEG C of water-bath insulation 2.5 hours.
4. the anti-avian influenza feed addictive of a kind of large-scale ecological poultry according to claim 1; it is characterized in that described hypericum perforatum fermentation meal is prepared with following method: the ratio adding activated yeast mixture 100ml in every 100g hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days.
5. the preparation method of a kind of anti-avian influenza feed addictive of large-scale ecological poultry described in claim 1; it is characterized in that described method is as follows: get Japanese Metaplexis Pericarp, the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis respectively; be ground into fine powder; cross 100 mesh sieves; by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
6. the using method of a kind of anti-avian influenza feed addictive of large-scale ecological poultry described in claim 1; it is characterized in that described method is as follows: by the basal diet feed of chicken and anti-avian influenza feed addictive; admixed together by the mass ratio of 5-10:1; put into mixer and stir 120-150 minute; take out, stir into pasty state for chicken feed with water.
7. the using method of the anti-avian influenza feed addictive of a kind of large-scale ecological poultry according to claim 6, is characterized in that the basal diet feed of described chicken and the mass ratio of anti-avian influenza feed addictive are 8:1.
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| CN112062716A (en) * | 2020-08-03 | 2020-12-11 | 河南佰景生物科技有限公司 | Hyperforin derivatives, use thereof and antiviral preparations containing the same |
| CN112655819A (en) * | 2020-11-30 | 2021-04-16 | 广西农业职业技术学院 | Anti-avian influenza feed additive for large-scale chicken raising and preparation method thereof |
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| JPH03160977A (en) * | 1989-11-20 | 1991-07-10 | Fuji Food Res:Kk | Health drink |
| CN100337651C (en) * | 2005-03-15 | 2007-09-19 | 华南农业大学 | Chinese medicine composition for preventing bird flu |
| CN1985861A (en) * | 2006-12-31 | 2007-06-27 | 中国农业科学院兰州畜牧与兽药研究所 | Process of preparing Hypericum perforatum piece Chinese medicine tablet |
| CN101007067A (en) * | 2007-01-23 | 2007-08-01 | 天津生机集团有限公司 | Antivirus medicine for birds and its preparation method |
| CN101023997A (en) * | 2007-03-28 | 2007-08-29 | 东北农业大学 | Anti-fowl-plague Chinese medicine and preparing method |
| CN101332255A (en) * | 2007-06-28 | 2008-12-31 | 保定冀中药业有限公司 | Traditional Chinese medicine extract for preventing avian influenza and preparation method |
| CN103027955A (en) * | 2011-09-30 | 2013-04-10 | 董根荣 | Granules for preventing and treating chicken infectious bursal disease and preparation method thereof |
| CN102908549B (en) * | 2012-11-14 | 2014-12-31 | 李志华 | Preparation method of Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu |
| CN103006848B (en) * | 2012-12-27 | 2014-04-02 | 西南民族大学 | Antiviral Chinese herbal medicine compound preparation for birds |
| CN103404714A (en) * | 2013-06-24 | 2013-11-27 | 金为强 | Feed for ducks in fattening period and preparation method of feed |
| CN103463225A (en) * | 2013-09-11 | 2013-12-25 | 丁玉兰 | Traditional Chinese medicine micro-ecologic preparation for preventing and treating newcastle disease and preparation method thereof |
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