CN103859168A - Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof - Google Patents
Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof Download PDFInfo
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- CN103859168A CN103859168A CN201410134154.XA CN201410134154A CN103859168A CN 103859168 A CN103859168 A CN 103859168A CN 201410134154 A CN201410134154 A CN 201410134154A CN 103859168 A CN103859168 A CN 103859168A
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- avian influenza
- hypericum perforatum
- parts
- feed addictive
- chicken
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Landscapes
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to an avian influenza resistant feed additive for large-scale ecological chicken breeding. The avian influenza resistant feed additive is prepared from the following raw materials in parts by weight: 50-120 parts of japanese metaplexis pericarp, 20-50 parts of a coarse hyperforin coarse material, 20-30 parts of astragalus membranaceus, 15-30 parts of honeysuckle and 20-30 parts of isatis root. The invention also relates to a preparation method for the feed additive. The preparation method comprises the steps of crushing the raw materials into fine powder, screening the fine powder through a 100-mesh sieve, and uniformly mixing the fine powder. The invention also relates to a use method of the feed additive. The use method comprises the steps of mixing a basic daily feed for chicken and the avian influenza resistant feed additive according to a mass ratio of (5-10):1, stirring the feed and the feed additive in a stirring machine for 120-150 minutes to obtain a mixture, taking out the mixture, and stirring the mixture in water to form paste which is used for feeding the chicken. The avian influenza resistant feed additive disclosed by the invention is used for feeding the chicken, so that the operation is easy, and the avian influenza resistant effect is outstanding.
Description
Technical field
The present invention relates to field of feed additive technology, especially bird feed additive technical field.
Background technology
At present; in feeding chicken in largely scale process; " two high one low " problem, particularly epidemic disease risk of ubiquitous low quality (product quality), high investment (aquaculture cost input), excessive risk (epidemic disease risk) is the important bottleneck of puzzlement China chicken aquaculture industry development always.
In recent years, along with improving constantly of living standards of the people, consumer has higher requirement to the quality of chicken.Due in feeding chicken in largely scale process for solving epidemic disease excessive risk problem, and use in a large number antibiotic and feed addictive is residual and accumulation, cause a series of food securities and health problem, impel people to start to pay close attention to the mode of raising chicken scattered on a small scale.Raise chicken scattered owing to belonging to pure natural feed or semi-artificial raising; in feed, do not add the chemical substance such as antibiotic, hormone; and chicken is naturally putting in a suitable place to breed in process; automatically take food the wild worm of weeds of occurring in nature etc.; chicken meat quality outclass the chicken of complete artificial feeding in large-scale cultivation, and this is a kind of ecologic breeding mode of producing green non-pollution food.But apparent, this ecological poultry mode, what bring is the drawback that small scale, growth cycle are long, output is few, benefit is low, both cannot create a large amount of economic benefits, also cannot meet increasing consumer demand.Meanwhile, although it is more less than the batch production disease epidemic disease of raising chickens to raise chicken scattered, but still can there is the state of an illness the epidemic disease etc. that spreads disease, finally still need to use antibiotic, cause antibiotic accumulation, affect food security.Therefore, people invest increasing sight how to reduce and even avoid using antibiotic, carry out large-scale ecological poultry.
The Chinese medicinal herb chicken feed of green non-pollution has just become more and more researchers and breeding enterprise to pay close attention to target.
Japanese Metaplexis Pericarp is the shell of Asclepiadaceae plant trailing plants Japonica Metaplexis japonica (Thunb.) Makino.The traditional Chinese medical science is thought, its energy clearing lung and eliminating phlegm, and loose stasis of blood hemostasis, cures mainly coughing with a lot of sputum, asthma, pertussis etc.Main product is with in Jiangsu-zhejiang Shanghai Area one, markets one's own products more.In prior art, do not have the report about the effect of Japanese Metaplexis Pericarp anti-avian influenza.The inventor, through a large amount of screening tests, has found that it has stronger anti-avian influenza effect first.
A large amount of research practice finds, Chinese medicine compound prescription has combination advantage aspect preventing and curing diseases, the curative effect of medication after compound compatibility be often greater than simply adding of simple curative effect and.
Hypericum perforatum is the dry herb of Garcinia maingayii hypericum perforatum Hypericum perforatum L..The extract of existing pharmacology and clinical trial certificate hypericum perforatum can effectively be used for the treatment of depressed and anxiety class psychosis, has been used for the treatment of clinically slightly, moderate depressive patients in the U.S. and European Union's Countries.In addition, its extract also tool is antiviral and strengthen immunologic function, and research finds that the hypericin in extract can reach 100% to the killing rate of H 5 N 1 avian influenza and H9N2 subtype virus.But hypericum perforatum traditional extraction technique method will be used multi-solvents and acid-base class chemical reagent, part improving technology need to add various chemical stabilizers, not only cost is high, complex process, and in crude extract, contain the part chemical substance harmful to chicken, chicken cannot directly be eaten.Main medicinal ingredient comprises the materials such as anthrone class (hypericin, pseudohypericin, different hypericin, former hypericin), phloroglucin class (this triphenol between hyperforine, acyl group), flavonoids (Quercetin, Hyperoside, rutin, amentoflavone etc.), mountain pass ketone and phenolic acid class.Tool antidepression, antiviral and enhancing immunologic function, its extract hypericin can reach 100% to the killing rate of H 5 N 1 avian influenza and H9N2 subtype virus.The traditional Chinese medical science thinks, its tool is clearing heat and detoxicating, astringing to arrest bleeding, effect of dampness removing.Cure mainly spitting of blood, spit blood, discharging fresh blood stool, traumatism and bleeding, treating rheumatic ostealgia, the raw sore of mouth and nose, pyogenic infections, burn.
The Radix Astragali is the dry root of legume astragalus mongolicus Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge..Chemical composition: contain sucrose, glucuronic acid, astragalus polyose A, B, C, D, lymphatic temperament, several amino acids, bitter principle, astragaloside, choline, folic acid, flavane compound and contain the various trace elements such as selenium, silicon, zinc, cobalt, copper, molybdenum.Have and have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, anti-stress, step-down and antibacterial action more widely.
Honeysuckle is the dry flower of caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicerahypoglauca Miq. or hair style honeysuckle Lonicera dasystyla Rehd. or the flower that band is just opened.Chemical composition: chlorogenic acid, isochlorogenic acid, sweet-scented osmanthus oxalic acid, cyanidenon-glucoside, lonicerin, saponin(e, waves oil, inositol, tannin, iridoid glycoside, sweroside, loganin, logaric acid, helexin aglucon, oleanolic acid; The functional components such as disacoside B, linalool, honeysuckle alcohol, geraniol, bata-phenethyl alcohol, phenmethylol, isodigeranyl flower alcohol, alpha-terpineol, Eugenol.The traditional Chinese medical science thinks that it is cold in nature, and taste is sweet, and slightly tart flavour has clearing heat and detoxicating, cool blood, clearing and activating the channels and collaterals effect.
Radix Isatidis is the dry root of cruciferae isatis Isatis indigotica Fort..Chemical composition: indigo glucoside, isatin, indigo, woaded blue glucoside B, uridine, uracil, hypoxanthine, salicylic acid, Daucosterol, cupreol, Radix Isatidis second element, the third element and fourth element, and the functional materials such as vegetable protein, resin-like thing, carbohydrate, sinigrin, several amino acids and trace element.The traditional Chinese medical science is thought and its nature and flavor bitter cold is cured mainly febrile virulent maculae; High heat headache; Major part pestilence; Tongue is dark reddish purple dark, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle is swollen; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma is told nosebleed, and pharynx is swollen, pinkeye, sore rash; Can prevent and treat Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis etc.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of anti-avian influenza feed addictive using in large-scale ecological poultry process, and the effect that makes this feed addictive control chicken infect bird flu is remarkable.
Another technical problem to be solved by this invention provides a kind of preparation method of aforementioned anti-avian influenza feed addictive, makes that its cost is low, convenient operation.
Technical problem to be solved by this invention is also to provide a kind of using method of aforementioned anti-avian influenza feed addictive, makes playing a role of its economical and efficient.
In order to solve the problems of the technologies described above, the applicant has carried out a large amount of raw material screening tests, has found that first Japanese Metaplexis Pericarp has stronger anti-avian influenza effect.In order to give full play to the combination advantage of Chinese medicine compound prescription anti-avian influenza, the applicant, on the basis of drug matching research, proposes following technical proposal:
An anti-avian influenza feed addictive for large-scale ecological poultry, is characterized in that described feed addictive is prepared from by the raw material of following mass fraction:
Japanese Metaplexis Pericarp 50-120 part, the thick material 20-50 of hypericum perforatum part, Radix Astragali 20-30 part, honeysuckle 15-30 part, Radix Isatidis 20-30 part;
The thick material of described hypericum perforatum is taking hypericum perforatum as raw material, is prepared from following method:
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 60-120g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2-3 hour, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40-180ml in every 100g hypericum perforatum meal, at 20-45 DEG C of condition bottom fermentation 12-25 days, obtain hypericum perforatum fermentation meal;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
The formula of described feed addictive is preferably:
100 parts of Japanese Metaplexis Pericarps, 30 parts of the thick materials of hypericum perforatum, 25 parts of the Radixs Astragali, 20 parts of honeysuckles, 25 parts of Radix Isatidis.
The optimal process parameter of preparation activated yeast mixture is: by dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours.
The optimal process parameter of preparing hypericum perforatum fermentation meal is: add the ratio of activated yeast mixture 100ml in every 100g hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days.
The preparation method of the anti-avian influenza feed addictive of described a kind of large-scale ecological poultry; it is characterized in that described method is as follows: get respectively Japanese Metaplexis Pericarp, the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis; be ground into fine powder; cross 100 mesh sieves; by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
The using method of the anti-avian influenza feed addictive of described a kind of large-scale ecological poultry, it is characterized in that described method is as follows: by the basal diet feed of chicken and anti-avian influenza feed addictive, the mass ratio of pressing 5-10:1 is admixed together, put into mixer and stir 120-150 minute, take out, water stirs into pasty state for chicken feed; Also, after can drying, moistureproof airtight package is preserved, for subsequent use.
When use, the basal diet feed of described chicken and the mass ratio of anti-avian influenza feed addictive are preferably 8:1.
Adopt anti-avian influenza feed addictive feeding chicken of the present invention, easy and simple to handle, control bird flu effect is remarkable.Its useful technique effect can be by following evidence.
The feed addictive of test example 1 different formulations is to infecting the preventive and therapeutic effect of bird flu chicken
1, test material:
Feed addictive of the present invention, prepares and uses by embodiment 11 methods.
Single Japanese Metaplexis Pericarp feed addictive, gets Japanese Metaplexis Pericarp, pulverizes, and crosses 100 mesh sieves, to obtain final product.Using method is with embodiment 11.
Remove Japanese Metaplexis Pericarp feed addictive, in formula, (in formula, only contain the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis) except not containing Japanese Metaplexis Pericarp, all the other methods of preparation and use are with embodiment 11.
Basal diet feed, self-control, every group of test chicken all gives the basal feed of same specification.
Amantadine hydrochloride is purchased from Dongbei Pharmaceutical General Factory.
Within 8 weeks, LingSPFJi You Harbin Veterinary Medicine Inst., China Academy of Agriculture Experimental Animal Center provides.
H5N1 subtype avian influenza virus is provided by animal influenza emphasis open laboratory of the Ministry of Agriculture.
2, method
Test is divided into 6 groups, and I group is Normal group, totally 10 SPF chickens.Every not basal diet feed containing any additive that daily gives.
II group is model group.Totally 45 SPF chickens.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Every not basal diet feed containing any additive that daily gives.
III group is feed group of the present invention, totally 38 SPF chickens.Attacking the front diet feed that is added with feed addictive of the present invention for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, be all added with the diet feed of feed addictive of the present invention every day.
IV group is amantadine control group, totally 38 SPF chickens.Attacking the front diet feed that is added with amantadine hydrochloride for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, be all added with the diet feed of amantadine hydrochloride every day.
V group is single Japanese Metaplexis Pericarp group, totally 38 SPF chickens.Attacking the front diet feed that is added with single Japanese Metaplexis Pericarp feed addictive for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, all give the diet feed of single Japanese Metaplexis Pericarp feed addictive every day.
VI group is Japanese Metaplexis Pericarp group, totally 38 SPF chickens.Attacking the front diet feed that is added with Japanese Metaplexis Pericarp feed addictive for 15 days of poison.Attacking toxic agent amount is 10
4eID50/0.1ml, every chicken muscle injection 0.2ml.Attack the malicious same day to off-test, all remove the diet feed of Japanese Metaplexis Pericarp feed addictive every day.
Start Continuous Observation 14 days from attacking poison, observe and record the death toll of chicken, then calculate protective rate (protective rate=survival number/total * 100%).
Data statistical approach: the relatively employing Chi-square Test of two sample rates.
3, result
Result of the test is in table 1, and result shows, the protective rate of feed group of the present invention reaches 63.16%, is greater than 60.53% of positive controls-amantadine group; Each administration group is compared with model group, and the equal tool of its difference is very significant (p<0.01); Feed group of the present invention and single Japanese Metaplexis Pericarp group and go compared with Japanese Metaplexis Pericarp group, the difference of its protective rate has significant (p<0.05).
The above results shows, the effect of Chinese medicine compound prescription feed addictive control bird flu of the present invention is remarkable, uses the successful of the present composition to be better than alone Japanese Metaplexis Pericarp or to use hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis composition.
The feed addictive of table 1 different formulations is to infecting the preventive and therapeutic effect of bird flu chicken
| Group | Survival number | Death toll | Protective rate |
| Normal group | 10 | 0 | 100.00% |
| Model group | 3 | 42 | 6.67% |
| Feed group of the present invention | 24 | 14 | 63.16%** |
| Amantadine group | 23 | 15 | 60.53%** |
| Single Japanese Metaplexis Pericarp group | 14 | 24 | 36.84%**，△ |
| Go Japanese Metaplexis Pericarp group | 13 | 25 | 34.21%**，△ |
Note: compared with model group, * * p<0.01; Compared with feed group of the present invention, △ p<0.05.
The impact of test example 2 feed addictive of the present invention on SPF chicken immuological function
1, test material:
Feed addictive of the present invention, prepares and uses by embodiment 11 methods.
Basal diet feed, self-control, every group of test chicken all gives the basal feed of same specification.
SPF chicken is provided by Harbin Veterinary Medicine Inst., China Academy of Agriculture's Experimental Animal Center.
2, method
40 SPF chickens of 1 age in days are divided into 2 groups at random, 20 every group.First group is feed group of the present invention, is added with the diet feed of feed addictive of the present invention every day.Other one group is blank group, gives the not diet feed containing any additive every day.Randomly draw normotrophic 10 chickens at 14 ages in days, dissect according to a conventional method, separate and measure the Immune Organs Index (immune organ weight is tried to achieve divided by corresponding chicken body weight) of thymus gland.Understand immune organ growth and development situation.At 21 ages in days, 5 of random chooses from 4 groups of test chickens, heart is adopted 2ml heparin anti-coagulating.On FAC, measure the content of CD3, CD4.
Data and statistics: data with
represent, carry out single factor variance with SPSS11.0 software and carry out significance,statistical analysis.
3, result
3.1 impacts of feed addictive of the present invention on Immune Organs Index
The results are shown in Table 2, result shows that the thymus index of feed group of the present invention is obviously better than blank group, and its difference has statistical significance (p<0.05).
The impact of table 2 feed addictive of the present invention on Immune Organs Index
| Group | Thymus index (%) |
| Feed group of the present invention | 0.65±0.12** |
| Blank group | 0.48±0.15 |
Note: compared with blank group, * p<0.05, * * p<0.01.
The impact of CD3+, CD4+T lymphocyte content in 3.2 feed addictive Peripheral Bloods of the present invention
The results are shown in Table 3, result shows that in the peripheral blood of feed group of the present invention, CD3+, CD4+T lymphocyte content are obviously better than blank group, and its difference has statistical significance (p<0.05,0.01).
The impact of CD3+, CD4+T lymphocyte content in table 3 feed addictive Peripheral Blood of the present invention
| Group | CD3+（%） | CD4+ |
| Feed group of the present invention | 54.4±7.6** | 31.6±7.3* |
| Blank group | 32.7±9.2 | 23.5±6.7 |
Note: compared with blank group, * p<0.05, * * p<0.01.
In sum, feed addictive of the present invention can significantly improve the immunity of chicken, and control bird flu effect is remarkable.
In order better to set forth technical scheme of the present invention, below in conjunction with detailed description of the invention, the present invention is further illustrated, but protection domain of the presently claimed invention is not limited to the following example.
Detailed description of the invention
Embodiment 1
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 60g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2 hours, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 12 days, obtain hypericum perforatum fermentation meal;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 50 parts of Japanese Metaplexis Pericarps, 50 parts of the thick materials of hypericum perforatum, 30 parts of the Radixs Astragali, 30 parts of honeysuckles, 30 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 5:1 mass ratio, puts into mixer and stirs 120 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 50.00% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 2
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 120g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 3 hours, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 180ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 25 days, obtain hypericum perforatum fermentation meal;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 120 parts of Japanese Metaplexis Pericarps, 20 parts of the thick materials of hypericum perforatum, 20 parts of the Radixs Astragali, 15 parts of honeysuckles, 20 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 10:1 mass ratio, puts into mixer and stirs 150 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 57.89% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 3
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 120 parts of Japanese Metaplexis Pericarps, 20 parts of the thick materials of hypericum perforatum, 30 parts of the Radixs Astragali, 30 parts of honeysuckles, 30 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 55.26% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 4
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 50 parts of Japanese Metaplexis Pericarps, 50 parts of the thick materials of hypericum perforatum, 20 parts of the Radixs Astragali, 15 parts of honeysuckles, 20 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 52.63% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 5
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 120 parts of Japanese Metaplexis Pericarps, 50 parts of the thick materials of hypericum perforatum, 20 parts of the Radixs Astragali, 30 parts of honeysuckles, 30 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 55.26% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 6
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 50 parts of Japanese Metaplexis Pericarps, 20 parts of the thick materials of hypericum perforatum, 30 parts of the Radixs Astragali, 15 parts of honeysuckles, 20 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 52.63% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 7
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 120 parts of Japanese Metaplexis Pericarps, 50 parts of the thick materials of hypericum perforatum, 30 parts of the Radixs Astragali, 15 parts of honeysuckles, 30 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 55.26% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 8
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 50 parts of Japanese Metaplexis Pericarps, 20 parts of the thick materials of hypericum perforatum, 20 parts of the Radixs Astragali, 30 parts of honeysuckles, 20 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 57.89% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 9
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 120 parts of Japanese Metaplexis Pericarps, 50 parts of the thick materials of hypericum perforatum, 50 parts of the Radixs Astragali, 30 parts of honeysuckles, 20 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 60.53% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 10
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 50 parts of Japanese Metaplexis Pericarps, 20 parts of the thick materials of hypericum perforatum, 20 parts of the Radixs Astragali, 15 parts of honeysuckles, 30 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
With reference to the method for test example 1, result shows that the present embodiment additive is 55.26% to the protective rate that infects bird flu chicken, and prevention effect is remarkable.
Embodiment 11
1, the preparation of the thick material of hypericum perforatum
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 80g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours;
(3) add the ratio of activated yeast mixture 100ml in the every 100g of hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2, the preparation of anti-avian influenza feed addictive
Take 100 parts of Japanese Metaplexis Pericarps, 30 parts of the thick materials of hypericum perforatum, 25 parts of the Radixs Astragali, 20 parts of honeysuckles, 25 parts of Radix Isatidis by quality respectively, be ground into fine powder, cross 100 mesh sieves, by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
3, the using method of anti-avian influenza feed addictive
By the basal diet feed of chicken and anti-avian influenza feed addictive, admixed together by 8:1 mass ratio, puts into mixer and stirs 130 minutes, takes out, and water stirs into pasty state for chicken feed; After residue person is dried, moistureproof airtight package is preserved, for subsequent use.
4, prevention effect test
See test example 1,2.
Claims (7)
1. an anti-avian influenza feed addictive for large-scale ecological poultry, is characterized in that described feed addictive is prepared from by the raw material of following mass fraction:
Japanese Metaplexis Pericarp 50-120 part, the thick material 20-50 of hypericum perforatum part, Radix Astragali 20-30 part, honeysuckle 15-30 part, Radix Isatidis 20-30 part;
The thick material of described hypericum perforatum is taking hypericum perforatum as raw material, is prepared from following method:
(1) dry hypericum perforatum herb is ground into meal with pulverizer;
(2) press dusty yeast 10g, edible rice flour 60-120g, the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2-3 hour, obtain activated yeast mixture;
(3) add the ratio of activated yeast mixture 40-180ml in every 100g hypericum perforatum meal, at 20-45 DEG C of condition bottom fermentation 12-25 days, obtain hypericum perforatum fermentation meal;
(4) hypericum perforatum is fermented meal is dried at 30-56 DEG C, obtains the thick material of hypericum perforatum.
2. the anti-avian influenza feed addictive that a kind of large-scale ecological is raised chickens according to claim 1, is characterized in that described feed addictive is prepared from by the raw material of following mass fraction:
100 parts of Japanese Metaplexis Pericarps, 30 parts of the thick materials of hypericum perforatum, 25 parts of the Radixs Astragali, 20 parts of honeysuckles, 25 parts of Radix Isatidis.
3. the anti-avian influenza feed addictive that a kind of large-scale ecological is raised chickens according to claim 1; activated yeast mixture described in it is characterized in that is prepared with following method: by dusty yeast 10g; edible rice flour 80g; the ratio of water 1000ml is carried out fermentation raw material preparation, after put into 25-37 DEG C of water-bath and be incubated 2.5 hours.
4. the anti-avian influenza feed addictive that a kind of large-scale ecological is raised chickens according to claim 1; it is characterized in that described hypericum perforatum fermentation meal prepared with following method: add the ratio of activated yeast mixture 100ml in every 100g hypericum perforatum meal, 20-45 DEG C of condition bottom fermentation 20 days.
5. a kind of preparation method of anti-avian influenza feed addictive of large-scale ecological poultry described in claim 1; it is characterized in that described method is as follows: get respectively Japanese Metaplexis Pericarp, the thick material of hypericum perforatum, the Radix Astragali, honeysuckle, Radix Isatidis; be ground into fine powder; cross 100 mesh sieves; by recipe quantity, above-mentioned fine powder is mixed, to obtain final product.
6. a kind of using method of anti-avian influenza feed addictive of large-scale ecological poultry described in claim 1, it is characterized in that described method is as follows: by the basal diet feed of chicken and anti-avian influenza feed addictive, the mass ratio of pressing 5-10:1 is admixed together, put into mixer and stir 120-150 minute, take out, water stirs into pasty state for chicken feed; Also, after can drying, moistureproof airtight package is preserved, for subsequent use.
7. the using method of the anti-avian influenza feed addictive that a kind of large-scale ecological is raised chickens according to claim 6, is characterized in that the basal diet feed of described chicken and the mass ratio of anti-avian influenza feed addictive are 8:1.
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