CN103006848A - Antiviral Chinese herbal medicine compound preparation for birds - Google Patents
Antiviral Chinese herbal medicine compound preparation for birds Download PDFInfo
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- CN103006848A CN103006848A CN2012105797317A CN201210579731A CN103006848A CN 103006848 A CN103006848 A CN 103006848A CN 2012105797317 A CN2012105797317 A CN 2012105797317A CN 201210579731 A CN201210579731 A CN 201210579731A CN 103006848 A CN103006848 A CN 103006848A
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Abstract
The invention discloses an antiviral Chinese herbal medicine compound preparation for birds, which is used for treatment of virosis of birds, and is prepared in the following steps of 1) weighting 40-120g of oldenlandia diffusa, 30-100g of chinese lobelia, 30-60g of honeysuckle, 30-60g of fructus forsythiae, 20-60g of isatis root, 20-60g of wild chrysanthemum, 20-50g of chrysanthemum and 10-20g of liquorice according to proportion; and 2) taking 320g as primary raw material extraction amount, drying and smashing and screening with a sieve of 200 meshes so as to obtain the target preparation. The antiviral Chinese herbal medicine compound preparation for birds has good curative effect on virosis such as chicken infectious bursal disease, duck viral hepatitis, H9 bird flu, head swelling syndrome of birds and the like.
Description
Technical field
The present invention relates to medicine for animals, be specifically related to a kind of poultry anti virus herb compound recipe and application.
Background technology
Animal viral disease is a most important class infectious disease, account for 60%～85% of all infectious disease, to aquaculture ([1] Wang Yinghai that brings about great losses, Wang Hai. the progress of antiviral Chinese herbal medicine [J]. the Chinese medicine journal, 2006,34 (1): 25-26.[2] Tang Guanghui. the recent progress in experimental study of domestic anti virus herb [J]. the Guangdong pharmacy, 2005,15 (6): 69-71.[3] Zhu Dan, Liu Huagang. the latest Progress of anti virus herb [J]. the china medical abstract internal medicine, 2005,26 (6): 747-751.).Because the problem that the special biological characteristics of virus and pathogenesis and antiviral drugs exist and use present situation, many viral diseases still lack effective medicine.In addition, it also is one of the reason that causes antiviral property medicine blank in the aquaculture ([4] Yang Xiaonong with antiviral drugs that edible animal is completely forbidden the end user, Liu Qun, Yu Xuehui etc. the progress [J] of poultry anti virus herb commonly used and application thereof. Jiangxi animal and veterinary magazine, 2007 (2): 8-10.).Compound Chinese medicinal preparation is classic prescriptions or the Chinese medicine preparation that forms at the basis of classic prescriptions plus-minus, such as " anti-sense electuary " (main component is Flos Lonicerae, Radix Paeoniae Rubra, Fructus Forsythiae etc.), is used for the treatment of influenza, viral pneumonia; " QINGRE JIEDU KOUFUYE " (main component is Flos Lonicerae, Radix Scutellariae, Radix Rehmanniae etc.) has stronger inhibitory action to multiple virus and antibacterial.The modern Chinese medicine theory thinks that viral disease is due to the heresy of epidemic disease, and the Therapeutic Principle who has pointed out viral disease, i.e. " righting " and " eliminating evil " ([5] Zhang Weimin, Yang Zengqi, minister in ancient times's element pearl. the Study of Medicinal Herbs progress [J] of resisiting influenza virus. the animal medicine progress, 2001,22 (4): 41-44.).
Summary of the invention
Above deficiency in view of prior art, the objective of the invention is the actual needs from aquaculture, in conjunction with the theoretical and modern relevant Chinese medicine research achievement of traditional Chinese veterinarian, take heat and toxic materials clearing away medicine such as Herba Hedyotidis Diffusae and Flos Loniceraes as principal agent, be aided with the drug supporting healthy energies such as the Radix Astragali, Radix Glycyrrhizae, filter out the Chinese medicine compound with antivirus action, be used for the treatment of animal viral disease.
The objective of the invention is to realize by following means.
One stud bird anti virus herb compound preparation is used for the treatment of poultry virus disease, adopts following steps to obtain:
1) takes by weighing in proportion Herba Hedyotidis Diffusae: 40g～120g; Herba Lobeliae Chinensis: 30g～100g; Flos Lonicerae: 30g～60g; Fructus Forsythiae: 30g～60g; Radix Isatidis: 20g～60g; Flos Chrysanthemi Indici: 20g～60g; Hemerocallis citrina Baroni: 20g～50g; Radix Glycyrrhizae: 10g～20g;
2) take 320g as the primary material extracted amount, drying was crushed to 200 orders, got target formulation.
The compound Chinese medicinal preparation of poultry antivirus action of the present invention according to the principles of formulating prescriptions of Chinese medicine compound, forms poultry anti virus herb compound recipe, the prescription characteristics according to traditional Chinese veterinarian theoretical " eliminating evil with righting, righting is with eliminating evil ":
1. strengthening vital QI to eliminate pathogenic factors lay equal stress on (traditional method eliminating pathogenic factor first and then reinforcing the vital QI, or eliminating evil after the first righting); 2. embody low dose of eliminating evil medicine enhancing human body immunity function (righting), heavy dose of virus replication (eliminating evil) that suppresses; 3. we with Herba Hedyotidis Diffusae, Herba Lobeliae Chinensis as eliminating evil principal agent, be used with the drug supporting healthy energy Radix Astragali, Radix Glycyrrhizae, and take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis and Flos Chrysanthemi Indici as accessory drugs, be used for the treatment of animal viral disease, cure mainly poultry pyretic toxicity disease, have heat-clearing and toxic substances removing, the effect of strengthening vital QI to eliminate pathogenic factors has good curative effect to animal viral disease.
Description of drawings
Fig. 1 is that Chinese medicine compound of the present invention is to infecting the curative effect table (n=80) of infectious bursal disease chicken.
Fig. 2 is that Chinese medicine compound of the present invention is to the curative effect table (n=75) of the sick duck of infected duck viral hepatitis.
Fig. 3 is that Chinese medicine compound of the present invention is to infecting the curative effect table (n=80) of the sick chicken of H9 subtype avian influenza.
Fig. 4 is that Chinese medicine compound of the present invention is to the curative effect (n=40) to the swollen syndrome virus chicken of infection fowl.
The specific embodiment
In following examples, the morbidity animal is the natural occurrence case of Sichuan province plant.According to clinical diagnosis and pathological anatomy, and in conjunction with the etiological diagnosis result of Southwest University for Nationalities Preventive Veterinary Medicine laboratory, be diagnosed as infectious bursal disease (IBD) case 240 examples, duck viral hepatitis (DVH) case 225 examples, H9 type bird flu (AI) case 240 examples and fowl syndrome case 120 example that swell.
The natural occurrence case of each disease is divided into 3 groups at random.Wherein, the Chinese medicine compound group is by 0.8% spice, successive administration 5d; Medicine control group fed astragalus polysaccharides, astragalus polysaccharides 400ppm spice, every day 1 time, continuously 5d; The blank group is not done any processing, free choice feeding and drinking-water.Observe every day such as the mental status respectively organize poultry, record feed intake, death toll, laying rate etc., Continuous Observation 15d.Calculate general mortality rate, and behind treatment 15d, carry out nosetiology and detect.
Curative effect determinate standard:
Disease continues to worsen, general mortality rate is higher than 20%, and it is invalid to be judged to;
Clinical symptoms fades away, feed intake is recovered gradually, general mortality rate is 10%～20%, is judged to relatively poor;
Clinical symptom disappearance, feed intake are recovered, fertility performance is recovered, general mortality rate be 0～5% and nosetiology detect negatively, be judged to recovery from illness.
Take 320g as the primary material extracted amount, take by weighing Herba Hedyotidis Diffusae: 80g; Herba Lobeliae Chinensis: 65g; Flos Lonicerae: 35g; Fructus Forsythiae: 35g; Radix Isatidis: 40g; Flos Chrysanthemi Indici: 40g; Hemerocallis citrina Baroni: 15g; Radix Glycyrrhizae: 10g.Drying was crushed to 200 orders, got target formulation.
Embodiment 1: compound preparation of the present invention is to the treatment example of infectious bursal disease (IBD)
Treatment the 5th day, Chinese medicine compound group and medicine matched group poultry spirit and feed intake were recovered gradually, the dead minimizing.Treatment the 7th day, Chinese medicine compound group poultry stopped death, and spiritual appetite is recovered fully.Duration of test, blank group poultry general mortality rate reaches 40% all more than 20% when the highest, cuts open inspection visible fabricius bursa, chest muscle and the severe haemorrhage of lower limb flesh, the kidney enlargement.As can be seen from Figure 1, Chinese medicine compound is suitable to the therapeutic effect of IBD with the medicine contrast, and its effective percentage is respectively 87% and 88%, but the relatively poor case percentage ratio of Chinese medicine compound group therapeutic effect significantly is lower than medicine matched group (P＜0.01).Although two groups improvement rate difference is not remarkable, the cure rate of Chinese medicine compound group is significantly higher than medicine matched group (P＜0.01).Therefore, compare with the medicine contrast, Chinese medicine compound can reduce the mortality rate of the sick chicken of IBD.
Embodiment 2: compound preparation of the present invention is to the treatment example of duck viral hepatitis (DVH)
During treating, the spirit of Chinese medicine compound group and medicine matched group poultry and feed intake are without obvious recovery, and mortality rate is also without obviously descending.But, append administration 2d after, the clinical indices of Chinese medicine compound group is clearly better than the medicine matched group.Duration of test, blank group mortality rate are up to more than 30%, even all death, cut open the visible liver severe haemorrhage of inspection, necrosis.As can be seen from Figure 2, the Chinese medicine compound group is 69% to the treated effect of DVH, apparently higher than 47% of medicine matched group.Although the therapeutic effect of Chinese medicine compound group is not very desirable, the improvement rate of Chinese medicine compound group and the cure rate all utmost point are significantly higher than medicine matched group (P＜0.01), and inefficiency is starkly lower than astragalus polysaccharides group (P＜0.01).
Embodiment 3: compound preparation of the present invention is to the treatment example of H9 type bird flu (AI)
Treatment the 3rd day, Chinese medicine compound group and medicine matched group poultry spirit and feed intake began to recover, and Chinese medicine compound group poultry stops death, and fertility performance begins to recover.After treatment the 7th day, the medicine matched group stopped death, and egg laying performance begins to recover.After morbidity the 7th day, blank group spirit and searching for food was recovered gradually voluntarily, but within the observation period every day have death, egg laying performance to fail to recover.Cut open the visible serious yolk peritonitis of inspection matched group poultry, nosetiology detects and is indicated as the Escherichia coli infection.As can be seen from Figure 3, the Chinese medicine compound group is 100% to the treated effect of H9 hypotype AI, and mortality rate descends, and poultry has recovered egg laying performance at short notice.The improvement rate of Chinese medicine compound group and cure rate all are higher than medicine matched group (P＜0.01).In addition, the relatively poor case percentage ratio of Chinese medicine compound group therapeutic effect extremely significantly is lower than medicine matched group (P＜0.01).Therefore, Chinese medicine compound obviously is being better than the medicine contrast aspect reduction mild bird flu mortality rate and the recovery of promotion body fertility performance.
Embodiment 4: compound preparation of the present invention is to swollen syndromic treatment example of fowl
Within the observation period, the voluntarily rehabilitation of natural occurrence case major part, but mortality rate is 5%～20%.In addition, the growth of morbidity poultry is unbalanced, and organic disease appears in Head And Face.Treatment the 3rd～4 day, Chinese medicine compound group poultry clinical symptoms was recovered comprehensively.As can be seen from Figure 4, Chinese medicine compound and astragalus polysaccharides are respectively 100% and 87% to the effective percentage of the swollen syndrome of fowl.The relatively poor case percentage ratio of Chinese medicine compound group therapeutic effect significantly is lower than medicine matched group (P＜0.01).The improvement rate of Chinese medicine compound and cure rate sum contrast apparently higher than medicine, and its cure rate is significantly higher than medicine contrast (P＜0.01).Therefore, Chinese medicine compound obviously is being better than the medicine contrast aspect reduction mortality rate and the recovery of promotion egg laying performance.
The plant Herb of finding Herba Hedyotidis Diffusae employing harvesting in autumn in experiment is used as medicine, and the compound preparation effect is very obvious.
Claims (3)
1. stud bird anti virus herb compound preparation is used for the treatment of poultry virus disease, adopts following steps to obtain:
1) takes by weighing in proportion Herba Hedyotidis Diffusae: 40g～120g; Herba Lobeliae Chinensis: 30g～100g; Flos Lonicerae: 30g～60g; Fructus Forsythiae: 30g～60g; Radix Isatidis: 20g～60g; Flos Chrysanthemi Indici: 20g～60g; Hemerocallis citrina Baroni: 20g～50g; Radix Glycyrrhizae: 10g～20g;
2) take 320g as the primary material extracted amount, drying was crushed to 200 orders, got target formulation.
2. stud bird anti virus herb compound preparation according to claim 1 is characterized in that,, takes by weighing Herba Hedyotidis Diffusae take 320g as the primary material extracted amount: 80g; Herba Lobeliae Chinensis: 65g; Flos Lonicerae: 35g; Fructus Forsythiae: 35g; Radix Isatidis: 40g; Flos Chrysanthemi Indici: 40g; Hemerocallis citrina Baroni: 15g; Radix Glycyrrhizae: 10g.
3. stud bird anti virus herb compound preparation according to claim 1 is characterized in that, described Herba Hedyotidis Diffusae is adopted and plucks Herb autumn and be used as medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859168A (en) * | 2014-04-03 | 2014-06-18 | 常熟理工学院 | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof |
| CN104286539A (en) * | 2014-10-16 | 2015-01-21 | 铜陵水之域生态养殖有限公司 | Traditional Chinese medicine feed for native chickens and preparation method thereof |
| CN104873568A (en) * | 2015-06-15 | 2015-09-02 | 河南牧翔动物药业有限公司 | Oral liquid for strengthening body resistance and detoxifying for animal and preparation method thereof |
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| CN1156595A (en) * | 1996-02-07 | 1997-08-13 | 田渭法 | Kangbingning (oral) capsule and preparing process thereof |
| CN1911302A (en) * | 2006-08-01 | 2007-02-14 | 河南辅仁药业集团有限公司 | Medicine composition for treating viral inflammation, and its prepn. method |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
| CN101940653A (en) * | 2010-09-04 | 2011-01-12 | 荣成市科学技术情报研究所 | Chinese medicament for treating viral influenza |
| CN102813721A (en) * | 2012-08-29 | 2012-12-12 | 郑州后羿制药有限公司 | Pharmaceutical composition for livestock heat clearing and livestock detoxifying and preparation method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156595A (en) * | 1996-02-07 | 1997-08-13 | 田渭法 | Kangbingning (oral) capsule and preparing process thereof |
| CN1911302A (en) * | 2006-08-01 | 2007-02-14 | 河南辅仁药业集团有限公司 | Medicine composition for treating viral inflammation, and its prepn. method |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
| CN101940653A (en) * | 2010-09-04 | 2011-01-12 | 荣成市科学技术情报研究所 | Chinese medicament for treating viral influenza |
| CN102813721A (en) * | 2012-08-29 | 2012-12-12 | 郑州后羿制药有限公司 | Pharmaceutical composition for livestock heat clearing and livestock detoxifying and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859168A (en) * | 2014-04-03 | 2014-06-18 | 常熟理工学院 | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof |
| CN104286539A (en) * | 2014-10-16 | 2015-01-21 | 铜陵水之域生态养殖有限公司 | Traditional Chinese medicine feed for native chickens and preparation method thereof |
| CN104873568A (en) * | 2015-06-15 | 2015-09-02 | 河南牧翔动物药业有限公司 | Oral liquid for strengthening body resistance and detoxifying for animal and preparation method thereof |
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Granted publication date: 20140402 Termination date: 20171227 |