CN1879686A - A Chinese medicinal composition for treating avian viral disease and preparation method thereof - Google Patents
A Chinese medicinal composition for treating avian viral disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese pharmaceutical composition for treating fowl virus diseases and process for preparation, wherein the composition comprises (by weight ratio) radix isatidis 50-150 parts, astragalus root 50-150 parts, epimedium 25-75 parts, dyers woad leaf 25-75 parts.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of avian viral disease.
Background technology
Along with the development of society and the change of prosperity of economy and human health idea, the idea of back to nature, the harmony between man and nature is more and more praised highly, and " dining table safely " received great concern, and people are also more and more high to the requirement of safe diet.The abuse of Western medicine has brought great diet hidden danger to livestock products is edible, and drug residue has become one of principal element that influences livestock products safety.Infectious bursal disease is as one of three big main eqpidemic diseases of harm aviculture, in some more intensive areas of raising chickens, replaced atypical newcastle and the first place that occupies infectious disease incidence, is regardless of kind, laying hen, broiler, the assorted chicken of meat; No matter whether immunity, all might fall ill, this disease causes the immunosuppressant of chickling, make the disease chicken to cause of diseases such as escherichia coli, adenovirus, Salmonella, chicken coccidiosis susceptible more, respond to inoculations such as horse Garrick vaccine, bursal disease vaccines descends, and therefore should disease cause huge harm to poultry husbandry.How to find a kind of pathogen is had directly kill or inhibitory action, reach by regulating the intrinsic antipathogen mechanism of animal body (as immune system, complement system etc.) that to press down viricidal effect be a problem that needs to be resolved hurrily simultaneously.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of green natural, noresidue harm are provided, the theory that meets green health had both had pathogen directly to be killed or inhibitory action, simultaneously by regulating the intrinsic antipathogen mechanism of animal body (as immune system, complement system etc.) but reach a kind of Chinese medicine composition for the treatment of avian viral disease of the effect of killing the virus.
Technical scheme of the present invention is summarized as follows:
A kind of Chinese medicine composition for the treatment of avian viral disease comprises by weight: 50～150 parts of Radix Isatidiss, 50～150 parts of the Radixs Astragali, 25～75 parts of Herba Epimedii, 25～75 parts of Folium Isatidiss.
Preferably: described Radix Isatidis is that 100 parts, the Radix Astragali are that 100 parts, Herba Epimedii are that 50 parts, Folium Isatidis are 50 parts.
A kind of preparation method for the treatment of the Chinese medicine composition of avian viral disease, be made up of following step: (1) takes by weighing by weight: 50～150 parts of Radix Isatidiss, 50～150 parts of the Radixs Astragali, 25～75 parts of Herba Epimedii, 25～75 parts of Folium Isatidiss, (2) add the purified water of each component total amount 2～3 times of weight, through percolation, to evaporate, be concentrated into 50 ℃ of relative densities be 1.05～1.2 concentrated solution; (3) purified water that adds concentrated solution 2～3 times of weight is made.
Preferably: described Radix Isatidis is that 100 parts, the Radix Astragali are that 100 parts, Herba Epimedii are that 50 parts, Folium Isatidis are 50 parts.
A kind of Chinese medicine composition for the treatment of avian viral disease of the present invention mainly has significant advantage to the prevention and the treatment of infectious bursal disease.Studies confirm that a kind of Chinese medicine composition for the treatment of avian viral disease of the present invention is external has direct inhibitory or killing effect to infectious bursal disease virus; Model to artificial challenge's infectious bursal disease also has significant protection and therapeutical effect; preceding 3 days of viral infection and infection administration simultaneously curative effect are better than infecting administration in back three days; a kind of Chinese medicine composition for the treatment of avian viral disease of clinical research confirmation has excellent curative to infectious bursal disease; especially can remove symptoms such as dysentery that viral infection causes rapidly, promote sick fowl to recover to search for food, promote laying rate and egg product matter to recover; recovery from illness in general 3～5 days, the Chinese medicine composition that is better than general extraction process evident in efficacy.
The present invention chooses various effective ingredient and is reasonably combined, and can prevent and treat viral disease and syndrome thereof that tame poultry often send out safely and effectively; Cost is low, cure rate is high, noresidue and applied range.
We are with a kind of Chinese medicine composition called after " oral liquid for strengthening healthy energy and relieving internal heat " for the treatment of avian viral disease of the present invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of Chinese medicine composition for the treatment of avian viral disease, made by following step: (1) takes by weighing: Radix Isatidis 100Kg, Radix Astragali 100Kg, Herba Epimedii 50Kg, Folium Isatidis 50Kg; (2) add the purified water of each component total amount 3 times of weight, through percolation, to evaporate, be concentrated into 50 ℃ of relative densities be 1.05 concentrated solution; (3) purified water that adds concentrated solution 3 times of weight is made.
Embodiment 2
A kind of Chinese medicine composition for the treatment of avian viral disease, made by following step: (1) takes by weighing: Radix Isatidis 50Kg, Radix Astragali 50Kg, Herba Epimedii 75Kg, Folium Isatidis 25Kg; (2) add the purified water of each component total amount 3 times of weight, through percolation, to evaporate, be concentrated into 50 ℃ of relative densities be 1.1 concentrated solution; (3) purified water that adds concentrated solution 2 times of weight is made.
Embodiment 3
A kind of Chinese medicine composition for the treatment of avian viral disease, made by following step: (1) takes by weighing: Radix Isatidis 150Kg, Radix Astragali 150Kg, Herba Epimedii 25Kg, Folium Isatidis 75Kg; (2) add the purified water of each component total amount 2 times of weight, through percolation, to evaporate, be concentrated into 50 ℃ of relative densities be 1.2 concentrated solution; (3) purified water that adds concentrated solution 3 times of weight is made.
Embodiment 4
A kind of preparation method for the treatment of the Chinese medicine composition of avian viral disease, make by following step:
(1) takes by weighing: Radix Isatidis 150Kg, Radix Astragali 150Kg, Herba Epimedii 25Kg, Folium Isatidis 75Kg;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 60 ℃ of temperature, 2 hours time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 3;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 4 hours, and quantity of solvent is 2 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 1.5 hours, and pressure is 200pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 1% of an extract gross weight;
(7) filter: adopt ultrafiltration membrance filter, cross 350 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into 50 ℃ of relative densities and be 1.05 concentrated solution;
(9) purified water that adds concentrated solution 2 times of weight is made.
Under vacuum state, in regulating the suction vaporization chamber, the influencing meridian effusion meter concentrates.The evaporation gas cools off to flow to through high-performance heat exchanger and reclaimed by flow container, and basin before solvent pump is input to extractor again can enter fresh solvent continuously and discharge extractum continuously, the continuous concentrate that gets, and the leaching medical material so moves in circles.
Embodiment 5
A kind of Chinese medicine composition for the treatment of avian viral disease, make by following step:
(1) takes by weighing: Radix Isatidis 50Kg, Radix Astragali 50Kg, Herba Epimedii 75Kg, Folium Isatidis 25Kg;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 120 ℃ of temperature, 1 hour time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 4;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 2 hours, and quantity of solvent is 3 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 2 hours, and pressure is 100pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 0.5% of an extract gross weight;
(7) filter: adopt ultrafiltration membrance filter, cross 200 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into 50 ℃ of relative densities and be 1.05 concentrated solution;
(9) purified water that adds concentrated solution 3 times of weight is made.
Embodiment 6
A kind of Chinese medicine composition for the treatment of avian viral disease, make by following step:
(1) takes by weighing: Radix Isatidis 150Kg, Radix Astragali 150Kg, Herba Epimedii 25Kg, Folium Isatidis 75Kg;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 90 ℃ of temperature, 2 hours time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 2;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 3 hours, and quantity of solvent is 3 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 1.5 hours, and pressure is 100pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 0.5% of an extract gross weight;
(7) filter: adopt ultrafiltration membrance filter, cross 300 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into 50 ℃ of relative densities and be 1.05 concentrated solution;
(9) purified water that adds concentrated solution 3 times of weight is made.
Adopt ultrafiltration membrance filter, have advantages such as to add chemical reagent, mild condition, no composition destruction, flow process weak point.
A kind of Chinese medicine composition for the treatment of avian viral disease of the present invention can be treated avian viral disease such as infectious bursal disease etc. effectively.Raw materials used resources of Chinese medicinal herb is extensive, and production technology is simple; The medicine noresidue has no side effect.
This product prescription compiles monarch, minister, helps, makes, and fully worships the principle of Chinese medicine " organic conception " and " dialectical executing controlled ", the treating both the principal and secondary aspects of a disease function of performance Chinese medicine, and its concrete function is summarized as follows with curing mainly:
Radix Isatidis: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.In epidemic febrile disease, a speckle, sore throat, erysipelas, carbuncle;
The Radix Astragali: invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.Be used for weak, the edema of the deficiency of vital energy.
Herba Epimedii: kidney invigorating and YANG supporting.
Folium Isatidis: heat-clearing and toxic substances removing
Effective monomer in the extraction process separate drug of uses advanced can effectively keep the effective ingredient in the Chinese medicine, and be rich in several amino acids and trace element, does not have organic solvent residual in the extract.The active ingredient of extracting in the side is the formation of blocking virus nucleic acid directly, suppress duplicating and rising in value of virus, but and the humoral immunization of enhancing body and cellular immunization, induce body to produce interferon, enhancing antibody forms, strengthen the phagocytosis of macrophage, thereby effectively kill pathogen pathogen.
A kind of Chinese medicine composition heat-clearing and toxic substances removing ability for the treatment of avian viral disease is strong, the clinical viral diseases such as treatment poultry infectious bursal disease, atypia infectious bursal disease, infectious bronchitis that are mainly used in.Prescription is suitable, and the variation of heat clearing away approach has taken into full account the thermotaxic characteristics of poultry, and the pestilence of dispelling the heat, dispel alleviates the sense of discomfort of body, thereby alleviates the symptom of disease to a certain extent, increases disease fowl appetite, promotes rehabilitation.This product is drug residue free in use, and toxicity is low, and is little to the body zest, is difficult for producing drug resistance, solves the outlet puzzlement fully.
Embodiment 7
The medication effect:
Effect experiment:
Method with the artificial challenge makes chickling that infectious bursal disease take place, analyze by statistics, prevention group chicken whole mental status behind counteracting toxic substances is better, it is also late symptom to occur, and symptom is obviously light than other two counteracting toxic substances groups, sickness rate is also low, " oral liquid for strengthening healthy energy and relieving internal heat " and the common extraction process production of oral liquid for strengthening healthy energy and relieving internal heat (common extraction process: refer to the common decocting in water in this area, spissated technology) to the extremely remarkable P of artificial onset's treatment group difference＜0.01, to natural occurrence " oral liquid for strengthening healthy energy and relieving internal heat " and the common extraction process production for treating of oral liquid for strengthening healthy energy and relieving internal heat group significant difference P＜0.05, illustrate that the infectious bursal disease that this Chinese medicine " oral liquid for strengthening healthy energy and relieving internal heat " causes virus has certain therapeutical effect.
The artificial therapeutic test of causing a disease is divided into 3 groups at random with 54 SPF chickens, every group 18, the A group is " oral liquid for strengthening healthy energy and relieving internal heat " treatment group, the B group is the common extraction process production for treating of IBD oral liquid for strengthening healthy energy and relieving internal heat group, the C group is matched group, 3 groups of chickens are contaminated with IBDV simultaneously, every chicken is with the strong malicious collunarium 0.2ml of IBDV, after waiting clinical symptoms to occur, to A group oral " oral liquid for strengthening healthy energy and relieving internal heat " 0.5ml/ only, twice of every day, B group chicken is that the common extraction process of oral oral liquid for strengthening healthy energy and relieving internal heat is only produced 0.5ml/, C group chicken injecting normal saline 1ml/ only observes morbidity death and the pathological change of chicken then, and itemized record.
Suppress earlier viral liquid to be made doubling dilution when IBD causes the test of Embryo Gallus domesticus pharmacosensitive test, inoculate 10 pieces of 10 age in days SPF Embryo Gallus domesticus through allantoic cavity, every piece of 0.2ml, " oral liquid for strengthening healthy energy and relieving internal heat " done respectively 1: 2,1: 4 times of amount dilution, and different dilution factor medicinal liquids are mixed with an amount of standby viral liquid equal-volume respectively, 37 ℃ of effect 1h inoculate each 10 pieces of 10 age in days SPF Embryo Gallus domesticus through allantoic cavity respectively, every embryo 0.2ml, do the PBS contrast simultaneously, 37.5 ℃ are continued hatching chicken embryo then, and the photograph egg was 1 time in per 12 hours, and the record death condition, until the 108h off-test.1 group is viral liquid group, and 2 groups is 1: 2 oral liquid for strengthening healthy energy and relieving internal heat, and 3 groups is 1: 4 Fuzheng Jiedu compositions group, and 4 groups is the PBS matched group.
The clinical treatment test selects typical IBD natural occurrence chicken group to be divided into 2 groups at random, one group of common extraction process production of oral oral liquid for strengthening healthy energy and relieving internal heat, and one group of oral " oral liquid for strengthening healthy energy and relieving internal heat " 0.5ml/ is only.
Experimental result
Table 1 " oral liquid for strengthening healthy energy and relieving internal heat " treatment IBD (avian infectious Fa Shi disease) result of the test
| Group | Quantity | The morbidity number | Death toll | Mortality rate | Cure number | Cure rate |
| The A group | 18 | 18 | 3 | 16.7 | 15 | 86.7 |
| The B group | 18 | 18 | 5 | 27.8 | 13 | 72.2 |
| The C group | 18 | 18 | 14 | 77.8 |
Behind the artificial therapeutic effect contamination 24h that causes a disease, test chicken begins to occur clinical symptoms: lassitude, to stand transfixed to the ground, and feather is fluffy and disorderly, and row's yellow green loose stool, diet reduce or are useless exhausted.After the medication, A group B group chicken takes a turn for the better since the 2d state of an illness, and the 3rd, 4d has dead chicken to occur, the basic rehabilitation of the chicken that survives behind the 5d, sb.'s illness took a turn for the worse after the 2nd day symptom occurring for the C group, begins to occur dead, 3-5d reaches dead peak, spontaneous recovery behind the not dead chicken 6d.
By table 1 as seen, " oral liquid for strengthening healthy energy and relieving internal heat " test group cure rate is 86.7%, and is higher by 14.5% than the common extraction process production of IBD oral liquid for strengthening healthy energy and relieving internal heat group cure rate, significant difference (P＜0.05), and the survival rate of C group only is 22.2%.
Each is organized dead chicken carry out pathology gradually and cut open inspection, from cuing open the inspection situation, nearly all dead chicken bursa serous coat edema and even gel-shaped; Cloaca is dispersed in the petechia, and thigh portion, chest muscle, lower limb flesh femoribus internus are hemorrhage; Pericardial effusion, coronary sulcus is hemorrhage; Renomegaly, the case that the time is long, urate deposition is obvious; Glandular stomach has ecchymosis, the enlargement of fabricius bursa yellow-white, and most of hyperemia are hemorrhage obviously.It is hemorrhage lighter that A organizes dead chicken, and especially gastrointestinal tract and fabricius bursa change not obvious.Inhibition IBD causes the pathogenic effect of Embryo Gallus domesticus and it is generally acknowledged that 24h should be irrelevant with virus function with interior dead person after the egg inoculation, and result of the test sees Table 2.
Table 2 oral liquid for strengthening healthy energy and relieving internal heat suppresses IBDV (avian infectious method disease virus) and causes the chicken embryo death situation
| Different time chicken embryo death number/piece | The inoculated into chick embryo number | The chicken embryo death number | The dead germ rate | ||||||||
| Group | 24h | 36h | 48h | 60h | 72h | 84h | 96h | 108h | |||
| 1 | 2 | 1 | 1 | 0 | 3 | 2 | 0 | 1 | 10 | 8 | 80.0 |
| 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 10 | 2 | 20.0 |
| 3 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 10 | 3 | 30.0 |
| 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 0 | 0 |
By table 2 as seen; " oral liquid for strengthening healthy energy and relieving internal heat " group dead germ rate is respectively 20%; 30%; and viral liquid group dead germ rate is 80%; show that " oral liquid for strengthening healthy energy and relieving internal heat " group rate of embryonic death is starkly lower than viral liquid matched group (P＜0.05 or P＜0.01), illustrates that " oral liquid for strengthening healthy energy and relieving internal heat " has the better protect effect to the embryo.
The clinical treatment result is 90.6% to the average cure rate of selected typical morbidity chicken group " oral liquid for strengthening healthy energy and relieving internal heat ", and average administration number of times is 4-7 time.
Table 3IBD natural occurrence chicken group therapeutic effect
| Group | Treatment number (only) | Cure number (only) | Death toll (only) | Cure rate (%) |
| " oral liquid for strengthening healthy energy and relieving internal heat " treatment group | 256 | 231 | 25 | 90.2 |
| The former extraction process production of IBD oral liquid for strengthening healthy energy and relieving internal heat | 234 | 182 | 28 | 78.0 |
Show that by table 3 " oral liquid for strengthening healthy energy and relieving internal heat " produce cure rate significant difference (P≤0.05) to the higher common extraction process of oral liquid for strengthening healthy energy and relieving internal heat of exempting from of the therapeutic effect of infectious bursal disease
Discuss
Above-mentioned result of the test shows that " oral liquid for strengthening healthy energy and relieving internal heat " is used for prevention and treatment IBD has obvious effects.As seen from Table 1 under the matched group mortality rate reaches 77.8% situation, " oral liquid for strengthening healthy energy and relieving internal heat " treatment group cure rate is 83.3%, reduce mortality rate 61.1%, clinical efficacy shows that " Fuzheng Jiedu compositions " treatment IBD cure rate is 90.2%, and is higher by 7% than laboratory.
Embodiment 8
The application example one of " oral liquid for strengthening healthy energy and relieving internal heat "
The diagnosis and treatment of the mixed infection of infectious bursal disease and colibacillosis
The Guilin raiser not certain, raise 4000 fast large-scale broiler, 28 age in days sudden onset, dead at that time 5, mainly draw white feces image-stone ash sample to glue anus, the householder thinks Pullorum Disease, drinks water with quinolones immediately, find dead 36 morning next day, poor effect increases the weight of on the contrary.
Clinical symptoms (at 13 o'clock in afternoon is to on-the-spot): sick chicken essence god is depressed, and the feather pine disorderly is afraid of cold and beats heap, what have trembles, suffers from diarrhoea, and discharges white thickness Calx sample or watery stools, and the perianal feather is by fecal pollution, have small part not rise, wing is sagging, closes one's eyes into lethargic state with crouching.
Cut open the inspection pathological change: chest muscle and leg muscle have ecchymosis, and liver has striped white downright bad, and glandular stomach and muscular stomach intersection have the petechia, and kidney becomes the piebaldism kidney, and urate deposition is arranged, the fabricius bursa enlargement.
Diagnosis:, be judged as infectious bursal disease according to pathology and clinical symptoms.
Control: strengthen management, ventilate, sterilize.
Medication: oral liquid for strengthening healthy energy and relieving internal heat, drink water evening, logotype 3 days.After three days, dead 2, remission.
The application example two of " oral liquid for strengthening healthy energy and relieving internal heat "
The treatment example of infectious bursal disease
Same symptoms appears in the laying hen that cultures in each county, east, certain year certain month Shijiazhuang successively: swollen eye socket, cough, snore, reductions of searching for food, laying rate descends, and uses this moment the fluorobenzene health to drink water, and gets final product disease controlling in 3-5 days.December 20 days finds that with the family of raising chickens, rear section the chicken death rate rises, and dead fast, feed intake descends fast, per 1000 chicken dead 10-20 every day only, dead about 60/day of the most serious family.It is dead to drink the aggravation of IV system.
At above-mentioned phenomenon, Chinese medicine " oral liquid for strengthening healthy energy and relieving internal heat " is used in suggestion, press 3g/ chicken use, cooperates multidimensional electrolyte etc. can control death rapidly in addition, the chicken group state that refreshes.
Analyze: through cuing open inspection: the most follicle of dead chicken is out of shape, intestinal mucosa is extensively hemorrhage, egg peritonitis, blue, the glandular stomach nipple petechial hemorrhage of cockscomb, mucosal bleeding under indivedual muscular stomach cutin membranes, cecal tonsil and following 3-5cm place small intestinal thereof have ulcer kitchen range, petechia.
Diagnosis: infectious bursal disease.
Sum up: similar symptom, early find early treatment, if use vaccine NDIV system drinking-water can cause mortality, available Chinese herbal and crude drugs preparations such as oral liquid for strengthening healthy energy and relieving internal heat, interpolation antimicrobial drug intestinal bar must be controlled or positive safe control secondary infection in the water simultaneously, facts have proved that expectant treatment is the may command state of an illness also, reduce mortality rate.
Claims (4)
1. Chinese medicine composition for the treatment of avian viral disease, its feature comprises by weight: 50～150 parts of Radix Isatidiss, 50～150 parts of the Radixs Astragali, 25～75 parts of Herba Epimedii, 25～75 parts of Folium Isatidiss.
2. a kind of Chinese medicine composition for the treatment of avian viral disease according to claim 1 is characterized in that described Radix Isatidis is that 100 parts, the Radix Astragali are that 100 parts, Herba Epimedii are that 50 parts, Folium Isatidis are 50 parts.
3. preparation method for the treatment of the Chinese medicine composition of avian viral disease, it is characterized in that being made up of following step: (1) takes by weighing by weight: 50～150 parts of Radix Isatidiss, 50～150 parts of the Radixs Astragali, 25～75 parts of Herba Epimedii, 25～75 parts of Folium Isatidiss, (2) add the purified water of each component total amount 2～3 times of weight, through percolation, to evaporate, be concentrated into 50 ℃ of relative densities be 1.05～1.2 concentrated solution; (3) purified water that adds concentrated solution 2～3 times of weight is made.
4. a kind of preparation method for the treatment of the Chinese medicine composition of avian viral disease according to claim 3 is characterized in that described Radix Isatidis is that 100 parts, the Radix Astragali are that 100 parts, Herba Epimedii are that 50 parts, Folium Isatidis are 50 parts.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015590B (en) * | 2007-02-13 | 2010-05-26 | 天津生机集团有限公司 | Jiawei Fuzheng Jiedu powder for treating chicken renal infectious bronchitis and its preparing process |
| CN102397510A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
| CN103372086A (en) * | 2012-04-23 | 2013-10-30 | 德州和膳生态农业有限公司 | Traditional Chinese medicine-based health care and epidemic prevention method for laying hen breeding |
| CN104644726A (en) * | 2013-11-19 | 2015-05-27 | 洛阳惠中兽药有限公司 | Traditional Chinese composition, preparation method and application thereof |
| CN104873568A (en) * | 2015-06-15 | 2015-09-02 | 河南牧翔动物药业有限公司 | Oral liquid for strengthening body resistance and detoxifying for animal and preparation method thereof |
| CN105641031A (en) * | 2014-12-02 | 2016-06-08 | 北京大北农动物保健科技有限责任公司 | Compound pharmaceutical composition for strengthening body resistance and removing toxin, use and feed thereof |
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2006
- 2006-05-18 CN CN 200610013750 patent/CN1879686A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015590B (en) * | 2007-02-13 | 2010-05-26 | 天津生机集团有限公司 | Jiawei Fuzheng Jiedu powder for treating chicken renal infectious bronchitis and its preparing process |
| CN102397510A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
| CN103372086A (en) * | 2012-04-23 | 2013-10-30 | 德州和膳生态农业有限公司 | Traditional Chinese medicine-based health care and epidemic prevention method for laying hen breeding |
| CN104644726A (en) * | 2013-11-19 | 2015-05-27 | 洛阳惠中兽药有限公司 | Traditional Chinese composition, preparation method and application thereof |
| CN105641031A (en) * | 2014-12-02 | 2016-06-08 | 北京大北农动物保健科技有限责任公司 | Compound pharmaceutical composition for strengthening body resistance and removing toxin, use and feed thereof |
| CN104873568A (en) * | 2015-06-15 | 2015-09-02 | 河南牧翔动物药业有限公司 | Oral liquid for strengthening body resistance and detoxifying for animal and preparation method thereof |
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