CN1330330C - Antivirus medicinal composition, preparation method and use - Google Patents
Antivirus medicinal composition, preparation method and use Download PDFInfo
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- CN1330330C CN1330330C CNB2005101360857A CN200510136085A CN1330330C CN 1330330 C CN1330330 C CN 1330330C CN B2005101360857 A CNB2005101360857 A CN B2005101360857A CN 200510136085 A CN200510136085 A CN 200510136085A CN 1330330 C CN1330330 C CN 1330330C
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Abstract
The present invention discloses an antivirotic medicine composition, and the preparation process and the purpose thereof. According to the weight percentage, the antivirotic medicine composition comprises 1 percent to 9 percent of honeysuckle flower extract, 2 percent to 10 percent of coptis root extract, 3 percent to 15 percent of hypericum perforatum extract and supplementary materials. The present invention has the preparation process that the honeysuckle flower extract, the coptis root extract and the hypericum perforatum extract are respectively crashed and sieved. The honeysuckle flower extract, the coptis root extract and the hypericum perforatum extract after sieved are weighed to take according to the weight percentage, and the rest is the supplementary materials. The antivirotic medicine composition is made up after mixing the medicine materials. The antivirotic medicine composition of the present invention is applied for the preparation of medicines preventing and curing the familiar virosis of poultries, the preventing and curing rate of the virosis can reach more than 90 percent, wherein the curing rate of infectious bursal disease of chickens reaches up to 98.6 percent. The present invention has little toxicity, low cost and convenient use, and can be directly added in animal feed and drinking water.
Description
Technical field
The present invention relates to a kind of anti virus herb compositions, preparation method and in the application of preparation antiviral drugs.
Background technology
At present, on treatment and prevention animal disease, adopt chemical synthetic drug, chemical synthetic drug dosage is little more, instant effect, but cure the symptoms, not the disease sometimes, there is the halfway defective of treatment, particularly antibiotic use makes bacterial strain produce drug resistance easily.For viral infection, the effect of chemical synthetic drug is also little.And viral infection usually takes place on animal body, in case occur, can cause heavy losses to aquaculture, also can cause potential harm to the mankind.For example: it is a kind of acute, the deadly infectious disease of chicken that newcastle disease virus infects, and is popular in all over the world, and particularly popular more extensive in Asia and China various places, the pathogen of newcastle disease is a kind of filterable virus, and the four seasons all can take place; Especially spring and autumn is more, and after chicken was subjected to extraneous viral infection, its symptom was: fervescence, and subtract suddenly and eat or do not eat, spirit is tired, general weakness, cephalledema, necking down, crop inflation, feces are yellow green.At present, this disease is not still had specific medicament both at home and abroad and can treat, have only injection newcastle disease vaccine to prevent, but vaccine needs the low temperature keeping, is difficult to spread to vast rural area, therefore, viral disease remains the formidable enemy of aquaculture.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide a kind of and can effectively prevent and treat the anti-viral pharmaceutical compositions of the common viral disease of poultry, we are with its called after " quick-acting poison gram ".
Second purpose of the present invention provides a kind of preparation method of anti-viral pharmaceutical compositions.
The 3rd purpose of the present invention provides the application of a kind of anti-viral pharmaceutical compositions at the medicine of the common viral disease of preparation control poultry.
Technical scheme of the present invention is summarized as follows:
A kind of anti-viral pharmaceutical compositions, percent comprises by weight: Flos Lonicerae extract 1～9%, Rhizoma Coptidis extract 2～10%, Herba Hyperici perforati extract 3～15%, surplus is an adjuvant.
Preferably described Flos Lonicerae extract is 3%, and Rhizoma Coptidis extract is 3%, Herba Hyperici perforati extract 6%, and surplus is an adjuvant.
Described adjuvant is at least a in sucrose, lactose, glucose, the sodium chloride.
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with Flos Lonicerae extract, Rhizoma Coptidis extract and Herba Hyperici perforati extract powder essence, sieve; (2) percent takes by weighing Flos Lonicerae extract 1～9% after sieving by weight, Rhizoma Coptidis extract 2～10%, and Herba Hyperici perforati extract 3～15%, surplus is an adjuvant, mix homogeneously is promptly made a kind of anti-viral pharmaceutical compositions.
Preferably Flos Lonicerae extract is 3%, and Rhizoma Coptidis extract is 3%, Herba Hyperici perforati extract 6%, and surplus is an adjuvant.
Described adjuvant is at least a in sucrose, lactose, glucose, the sodium chloride.
A kind of anti-viral pharmaceutical compositions is prevented and treated the application of the medicine of the common viral disease of poultry in preparation.
A kind of anti-viral pharmaceutical compositions of the present invention is a pure Chinese medicinal preparation, the bird flu H of Herba Hyperici perforati extract wherein (active component is a hypericin) to just spreading in worldwide at present
5N
1And H
9N
2Subtype virus has high killing rate, cooperates Rhizoma Coptidis, Flos Lonicerae extract, and the energy better prevention comprises the multiple viral disease of bird flu.Clinical trial shows that this product can reach more than 90% the control rate of viral disease, wherein to the cure rate of infectious bursal disease up to 98.6%.This product toxicity is little, and cost is lower, and is easy to use, can directly be added in animal feed and the drinking water, plays the preventive effect to virus.
Description of drawings:
Fig. 1 is the process chart of the preparation method of a kind of anti-viral pharmaceutical compositions of the present invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of anti-viral pharmaceutical compositions comprises: Flos Lonicerae extract 3 grams, Rhizoma Coptidis extract 3 grams, Herba Hyperici perforati extract 6 grams, sucrose 88 grams.
Embodiment 2
A kind of anti-viral pharmaceutical compositions comprises: Flos Lonicerae extract 1 gram, Rhizoma Coptidis extract 2 grams, Herba Hyperici perforati extract 10 grams, lactose 87 grams.
Embodiment 3
A kind of anti-viral pharmaceutical compositions comprises: Flos Lonicerae extract 9 grams, Rhizoma Coptidis extract 10 grams, Herba Hyperici perforati extract 3 grams, glucose 78 grams.
Embodiment 4
A kind of anti-viral pharmaceutical compositions comprises: Flos Lonicerae extract 6 grams, Rhizoma Coptidis extract 10 grams, Herba Hyperici perforati extract 15 grams, sodium chloride 69 grams.
Embodiment 5
A kind of anti-viral pharmaceutical compositions, percent comprises by weight: Flos Lonicerae extract 2 grams, Rhizoma Coptidis extract 5 grams, Herba Hyperici perforati extract 4 grams, glucose 84 grams, sodium chloride 5 grams.
Embodiment 6
A kind of anti-viral pharmaceutical compositions, percent comprises by weight: Flos Lonicerae extract 5 grams, Rhizoma Coptidis extract 2 grams, Herba Hyperici perforati extract 10 grams, sucrose 80 grams, sodium chloride 3 grams.
Embodiment 7
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 3 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 3 grams, and Herba Hyperici perforati extract 6 grams, sucrose 88 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 8
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 1 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 2 grams, and Herba Hyperici perforati extract 10 grams, lactose 87 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 9
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 9 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 10 grams, and Herba Hyperici perforati extract 3 grams, glucose 78 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 10
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 4 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 3 grams, and Herba Hyperici perforati extract 6 grams, sodium chloride 87 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 11
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 5 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 2 grams, and Herba Hyperici perforati extract 8 grams, glucose 80 grams, sodium chloride 5 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 12
A kind of preparation method of anti-viral pharmaceutical compositions comprises the steps that (1) respectively with after Flos Lonicerae extract, Rhizoma Coptidis extract and the Herba Hyperici perforati extract oven dry powder essence, sieve; (2) Flos Lonicerae extract 3 that takes by weighing after sieving restrains, Rhizoma Coptidis extract 3 grams, and Herba Hyperici perforati extract 6 grams, sucrose 80 grams, sodium chloride 8 grams, mix homogeneously sieves, and promptly makes a kind of anti-viral pharmaceutical compositions.
Embodiment 13
According to the diagnosis and treatment method of motherland's traditional Chinese medical science, be the principles of formulating prescriptions in line with " heat-clearing and toxic substances removing, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature should promote the production of body fluid by lung spleen reinforcing dampness " to " comprehensive adjustment, the mass prevention and mass treatment " of pestilence, heat, typhoid uniqueness; Through experiment screening, with Flos Lonicerae, Rhizoma Coptidis extract, Herba Hyperici perforati extract is made anti-viral pharmaceutical compositions, can suppress virus multiplication; Form with modern extraction process refine, have antiviral one's best quality.These product can directly be added in animal feed and the drinking water, control virus.The function of its maximum promptly directly acts on the process that viral DNA or RNA (bird flu promptly belongs to this viroid) transcribe, and suppresses the breeding of virus.
Chlorogenic acid in the Flos Lonicerae extract has effects such as anti-bacteria and anti-virus, hemostasis, anti-hepatitis, and Flos Lonicerae also has the effect of enhancing immunity simultaneously, can induce body to produce interferon, improves the body function of disease fowl, mitigate the disease.The effect that also has heat-clearing and toxic substances removing, effectively relief of symptoms.
Rhizoma Coptidis extract: berberine has " heat clearing and damp drying, eliminating fire and detoxication " effect, and the effect of well inducing sweat is arranged, and can effectively alleviate the fervescence that virus causes, and alleviates clinical symptoms.Thereby recovery appetite reduces mortality rate.Simultaneously, have antibacterial action, all can suppress Grain-positive, negative bacteria.Antibacterial secondary infection behind the energy effectively preventing viral infection.Viral disease often causes the resistance of body to descend, at this moment bacterial disease is understood secondary or is occurred together, and these bacterial infections often also are the reasons that the rate that causes death raises, and the main effective ingredient of Rhizoma Coptidis extract is a berberine sulfate, can suppress bacteriotoxic generation, antibacterial action is arranged simultaneously.
Herba Hyperici perforati extract: the main active of Herba Hyperici perforati extract " hypericin " suppresses virus activity by influencing the assembling of virus replication circulation with dispose procedure, promptly may be by disturbing retroviral infection, the shelling of blocking virus suppresses virus and sprouts, and suppresses duplicating of virus.During production with after the described raw material stoving, sieve the back remix evenly become powder.
During use, this powder is added hello chicken in the chicken feedstuff by certain weight, just can prevent diseases such as newcastle disease, infectious bursal disease.
1, to the experiment of newcastle disease (ND)
This product (a kind of anti-viral pharmaceutical compositions that embodiment 7 makes) of having studied 5 kinds of concentration joins in the chick embryo fibroblast (CEE) of cultivating 24h, inoculation NDV IV is after cultivating 12h again, with dimethyl diaminophenazine chloride dyestuff absorptionmetric determination CEF activity, estimate the influence of this product on cell proliferation and opposing viral infection thereof in inoculation back 72h with this.The measurement result explanation can significantly promote CEE propagation with this product in high concentration (1600 μ g/ml), inferior high concentration (1200 μ g/ml), and inferior high concentration significantly promotes the infection of CEF opposing NDV.In addition this product is joined among the CEF that cultivates 24h with 3 kinds of orders with NDVI, IV system: add earlier to add behind virus inoculation after this product, the first virus inoculation and add after this product, virus and this product are mixed, the tissue culture infective dose (TCID50) of 72h mensuration NDV I system and the HI of NDV IV system tire behind virus inoculation, to estimate the influence of this product to the NDV infection cell.The result shows: this product fashionablely has good inhibitory effect to NDV adding prior to virus.
2, the clinical efficacy of newcastle disease is tested
| Numbering | Group | Sickness rate % | Mortality rate % | The course of disease |
| A | Positive controls | 96.7(29/30) | 96.7(29/30) | 7 |
| B | Healthy group | 0(0/30) | 0(0/30) | 0 |
| C | The ribavirin therapy group | 83.3(25/30) | 16.6(5/30) | 6 |
| D | Quick-acting poison gram matched groups | 93.3(28/30) | 6.67(2/30) | 7 |
| E | " Lonicerae and Forsythiae Powder " matched group | 90.0(27/30) | 23.0(7/30) | 7 |
This result of the test shows, analyzes by statistics, and quick-acting malicious gram groups and ribavirin matched group difference is (P＜0.01, treatment group and " Lonicerae and Forsythiae Powder " matched group significant difference (P＜0.05 extremely significantly.
3, to the experiment of infectious bursal disease (IBD)
This product can induce body to produce interferon, regulates body's immunity, and enhancing antibody forms, and can be used for treating IBD.I the technical research personnel of company study this product to the inhibitory action that chicken infectivity bursa of Fabricius virus (IBDV) infects CEF, have tentatively obtained gratifying results.Studies show that this product has stronger inhibitory action to IBDV, only dead 1 of Embryo Gallus domesticus, all the other all strong living at 120h.This product is treated IBD, and cure rate reaches 98.6%.
The medication effect
Application example 1, Tianjin Dong Changtun
The chicken group has infected newcastle, the decline of searching for food, and spirit is depressed, and dissect: the glandular stomach mammillitis is hemorrhage, and chicken stomach fat is hemorrhage, and the interior mucus of Fa Shi capsule becomes many colors and thickens, and it is hemorrhage to have occurred the Semen Jujubae sample in the intestinal, mortality.
Quick-acting poison grams 3 days, mortality rate does not rise, the increase of searching for food
Application example 2, Mare Tranquillitatis Yang scholar
The symptom of turning one's head individually, head and neck chatter, the chicken cockscomb meat whisker cyanosis of dying of illness, toe scale drying, have hemorrhage, the decline of searching for food, the dead rising, dissect: trachea whole process is hemorrhage, and purulent secretion is arranged, and bronchus also has expectorant, pulmonary venous pleonaemia necrosis, SN, atrophy of thymus gland, the pancreas degeneration, necrosis, mesentery has the petechia, the breastbone inner membrance is hemorrhage, meningorrhagia, glandular stomach diffuse hemorrhage, the muscular stomach inwall is hemorrhage, the fabricius bursa atrophy, and last tentative diagnosis is the unknown cause virosis.
Quick-acting poison gram 7 bags of logotypes every day 4 days, vitamin C+multidimensional logotype 7 days, cod-liver oil+ammonium chloride logotype 3 days suitably cooperated the astragalus polysaccharides logotype 3 days, and after the course of treatment, chicken group symptom obviously disappears, and mortality has also descended, and the chicken group is controlled
Application example 3, the Liu Xiang village, Mare Tranquillitatis
Catch sight of the chicken that dies of illness at 28 ages in days and rise gradually, and cannot not search for food longly, and draw just green, also have plenty of the green HUANGBAI(sic) feces that just clips, also have special different hiding, cut open inspection through doctor, glandular stomach is hemorrhage, muscular stomach is hemorrhage, and intestinal mucosa comes off, the fabricius bursa atrophy, trachea hyperemia, 1/3 Os Gallus domesticus head necrosis, sick Ji Xiao Of-thin, the course of disease is controlled.
Claims (7)
1. anti-viral pharmaceutical compositions is characterized in that percent comprises by weight: Flos Lonicerae extract 1～9%, and Rhizoma Coptidis extract 2～10%, Herba Hyperici perforati extract 3～15%, surplus is an adjuvant.
2. a kind of anti-viral pharmaceutical compositions according to claim 1 is characterized in that described Flos Lonicerae extract is 3%, and Rhizoma Coptidis extract is 3%, Herba Hyperici perforati extract 6%.
3. a kind of anti-viral pharmaceutical compositions according to claim 1 and 2 is characterized in that described adjuvant is at least a in sucrose, lactose, glucose, the sodium chloride.
4. the preparation method of an anti-viral pharmaceutical compositions is characterized in that comprising the steps that (1) respectively with Flos Lonicerae extract, Rhizoma Coptidis extract and Herba Hyperici perforati extract powder essence, sieve; (2) percent takes by weighing Flos Lonicerae extract 1～9% after sieving by weight, Rhizoma Coptidis extract 2～10%, and Herba Hyperici perforati extract 3～15%, surplus is an adjuvant, mix homogeneously is promptly made a kind of anti-viral pharmaceutical compositions.
5. the preparation method of a kind of anti-viral pharmaceutical compositions according to claim 4 is characterized in that described Flos Lonicerae extract is 3%, and Rhizoma Coptidis extract is 3%, Herba Hyperici perforati extract 6%.
6. according to the preparation method of claim 4 or 5 described a kind of anti-viral pharmaceutical compositions, it is characterized in that described adjuvant is at least a in sucrose, lactose, glucose, the sodium chloride.
7. the arbitrary anti-viral pharmaceutical compositions application in the medicine of the common viral disease of preparation control poultry among the claim 1-3.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101360857A CN1330330C (en) | 2005-12-31 | 2005-12-31 | Antivirus medicinal composition, preparation method and use |
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| CNB2005101360857A CN1330330C (en) | 2005-12-31 | 2005-12-31 | Antivirus medicinal composition, preparation method and use |
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| CN1330330C true CN1330330C (en) | 2007-08-08 |
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| CNB2005101360857A Expired - Fee Related CN1330330C (en) | 2005-12-31 | 2005-12-31 | Antivirus medicinal composition, preparation method and use |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856495B (en) * | 2009-04-09 | 2012-06-06 | 河南惠通天下动物药业有限公司 | Medical composition and mixture for treating chicken infectious bursal disease and preparation method thereof |
| CN102370092A (en) * | 2011-09-24 | 2012-03-14 | 长治市雄丰清真养殖屠宰有限公司 | Feed combination capable of preventing and controlling calf and lamb salmonellosis |
| CN104288436A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Veterinary injection with effects of astringing intestine to stop diarrhea and preparation method of veterinary injection |
| CN108743923A (en) * | 2018-06-28 | 2018-11-06 | 河南省帝方生物制药有限公司 | A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry |
| CN108936041A (en) * | 2018-06-29 | 2018-12-07 | 广西万寿谷投资集团股份有限公司 | A kind of feed addictive and preparation method thereof for preventing and treating newcastle disease |
| CN112293737A (en) * | 2020-12-01 | 2021-02-02 | 曾晓飞 | Omega 3 and phillyrin combined plant antiviral and anti-inflammatory food supplement |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401369A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Antiviral, antibacterial and antiinflammatory herbal injection for treating livestock and fowl infectious disease |
| CN1436562A (en) * | 2002-02-08 | 2003-08-20 | 湖北丽益医药科技有限公司 | Hypericum perforatum extract and its prepn process and medicine composition |
| CN1452981A (en) * | 2003-05-17 | 2003-11-05 | 广西化工生物技术研究所 | Herpes virus treating medicine composition and its production process |
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2005
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1436562A (en) * | 2002-02-08 | 2003-08-20 | 湖北丽益医药科技有限公司 | Hypericum perforatum extract and its prepn process and medicine composition |
| CN1401369A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Antiviral, antibacterial and antiinflammatory herbal injection for treating livestock and fowl infectious disease |
| CN1452981A (en) * | 2003-05-17 | 2003-11-05 | 广西化工生物技术研究所 | Herpes virus treating medicine composition and its production process |
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