CN104784327A - Traditional Chinese veterinary medicine composition for treating respiratory diseases of chicken and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine composition for treating respiratory diseases of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese veterinary medicine composition for treating respiratory diseases of chicken. The traditional Chinese veterinary medicine composition is a preparation prepared from the following medicinal raw materials in parts by weight: 2-5 parts of houttuynia cordata, 1-3 parts of radix bupleuri, 1-3 parts of dandelion, and 1-3 parts of honeysuckle. The invention further provides a preparation method and use of the traditional Chinese veterinary medicine composition. The traditional Chinese veterinary medicine composition disclosed by the invention is reasonable in compatibility and has obvious curative effects for preventing and treating respiratory diseases of chicken, such as infectious bronchitis, infectious bursal diseases, Marek's diseases of chicken, Newcastle diseases and/or bird flu; and a drug choice simple in component and low in cost is provided for veterinary clinics.
Description
Technical field
The invention belongs to field of veterinary, relate to a kind of Chinese veterinary medicinal composition for the treatment of respiratory disease of chicken and preparation method thereof.
Background technology
The respiratory tract class disease of chicken is the modal disease in chicken farm, comprise infectious bronchitis, infectious bursal disease, chicken Marek's disease, newcastle disease and bird flu etc., this kind of disease has very strong infectiousness mostly, once cause large-area infection in chicken farm after morbidity, chicken morbidity and even death, cause huge loss to chicken farm.Infectious bronchitis of chicken (Infectious bronchitis, IB) be by infectious bronchitis virus (Infectious bronchitis virus, the one of the chicken IBV) caused is acute, the viral disease that high degree in contact infects, this disease is the most serious for cold season with Winter-Spring, spread to national most area, infected chicken clinical symptoms shows as cough, sneeze, trachea rale, the price of deed declines, the productivity loses, death rate increase etc., laying hen infects this after being ill, egg production reduces greatly, protein quality declines fairly obvious, huge economic loss is caused to poultry husbandry.Infectious bursal disease (Infectious bursal disease, IBD) be inhibitive ability of immunity, the high degree in contact sexually transmitted disease of a kind of serious harm chickling caused by infectious bursal disease virus (Infectious bursaldisease virus, IBDV).Primary disease feature is that sickness rate is high, the course of disease is short, affect chicken house fertility performance and cause direct economic loss, can immunosuppressant be caused simultaneously, make chicken decline to the immunne response of multiple vaccine, cause immuning failure, thus chicken group is increased the susceptibility of other pathogen.
The treatment of current chicken respiratory class disease adopts the biochemical drugs such as vaccine virus immunization, interferon, immunoglobulin, immune ribonucleic acid to treat more, there is price costly, the shortcomings such as curative effect is not remarkable; Antibiotic a large amount of use, may cause chicken to produce drug resistance, further the secondary infection of aggravation chicken group.Explore the attention that cheap, eutherapeutic treatment by Chinese herbs respiratory disease of chicken is more and more subject to veterinary clinic, a large amount of Chinese medicine not only has the curative effect of heat-clearing and toxic substances removing, anti-bacteria and anti-virus, also has the effect improving immunity.The Chinese medicine class veterinary drug of present treatment chicken respiratory class disease has pertinent literature report, and such as application number is CN98113732, and denomination of invention is the patent of " immunization powder ", provides a kind of herbal composite preventing and treating fowl diseases; Application number is CN201010262411, and denomination of invention is the patent of " pharmaceutical composition being used for the treatment of avian infectious bronchitis and preparation method thereof ", provides a kind of pharmaceutical composition for the treatment of avian infectious bronchitis; Application number is CN201110071886, and denomination of invention is the patent of " a kind of Chinese medicine composition for the treatment of respiratory disease of chicken ", provides a kind of Chinese medicine composition for the treatment of respiratory disease of chicken.But the equal complicated components of Chinese medicine class veterinary drug of report, causes cost increase, the preparation method complexity of preparing medicine.
Summary of the invention
The object of the present invention is to provide a kind of component simple, to treatment respiratory disease of chicken Chinese veterinary medicinal composition evident in efficacy and its production and use.
The invention provides a kind of Chinese veterinary medicinal composition for the treatment of respiratory disease of chicken, it is the preparation that the crude drug containing following weight proportioning is prepared from:
Herba Houttuyniae 2-5 part, Radix Bupleuri 1-3 part, Herba Taraxaci 1-3 part, Flos Lonicerae 1-3 part.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 3 parts, Radix Bupleuri 2 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part.
Chinese veterinary medicinal composition of the present invention, further, containing the Rhizoma Atractylodis Macrocephalae in crude drug, its weight proportion is: Rhizoma Atractylodis Macrocephalae 2-5 part.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 2-5 part, Radix Bupleuri 1-3 part, Rhizoma Atractylodis Macrocephalae 2-5 part, Herba Taraxaci 1-3 part, Flos Lonicerae 1-3 part.
Still more preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 2 parts, Radix Bupleuri 1 part, the Rhizoma Atractylodis Macrocephalae 2 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part; Or
Herba Houttuyniae 3 parts, Radix Bupleuri 2 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part; Or
Herba Houttuyniae 4 parts, Radix Bupleuri 1 part, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part.
The present composition is active component by the protogenic medicinal powder of above-mentioned raw materials medicine or water or extractive with organic solvent, adds the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, the dosage form of described oral formulations is tablet, unguentum, powder, decoction, pill, capsule, oral liquid.
The invention provides a kind of preparation method of described Chinese veterinary medicinal composition, it comprises the steps:
A, take the crude drug of each weight proportion;
B, crude drug are beaten powder or are added water or organic solvent extraction, add the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Present invention also offers a kind of preparation method of described Chinese veterinary medicinal composition, it comprises the steps:
A, take the crude drug of each weight proportion;
B, get Herba Houttuyniae, Radix Bupleuri, extract volatile oil, filtrate is for subsequent use;
C, the Rhizoma Atractylodis Macrocephalae decoct with water extraction, are condensed into clear paste, add 95% ethanol and make alcohol content be 70%, filter, collecting precipitation, dry, for subsequent use;
D, get Herba Taraxaci, Flos Lonicerae decocts with water, decocting liquid and step b filtrate merge, filter, it is 1.10 ~ 1.15 (60 DEG C) that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, cold preservation, filter, filtrate reduced in volume to without alcohol, adds volatile oil prepared by b step and Rhizoma Atractylodis Macrocephalae extract prepared by step c, adds the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Present invention also offers the purposes of described Chinese veterinary medicinal composition in the medicine of preparation treatment respiratory disease of chicken.Wherein, described respiratory disease of chicken is infectious bronchitis of chicken, infectious bursal disease, chicken Marek's disease, newcastle disease and/or bird flu.
Chinese veterinary medicinal composition compatibility provided by the invention is reasonable, infectious bronchitis of chicken, infectious bursal disease, chicken Marek's disease, newcastle disease and/or bird flu etc. are comprised to control respiratory disease of chicken evident in efficacy, for veterinary clinic provides a kind of component medicament selection simple, with low cost.
Detailed description of the invention
Be described further with embodiment below, but the present invention is not limited to these embodiments.
Embodiment 1 oral liquid preparation of the present invention
Prescription: Herba Houttuyniae 200g, Radix Bupleuri 100g, Rhizoma Atractylodis Macrocephalae 200g, Herba Taraxaci 100g, Flos Lonicerae 100g.
Preparation technology:
(1) get Herba Houttuyniae, Radix Bupleuri, add 30 times amount water distillation and extraction 6 hours, collect volatile oil and filtrate, for subsequent use.
(2) Rhizoma Atractylodis Macrocephalae adds 20 times amount water boiling and extraction three times, each 1 hour, and filter, filtrate is concentrated into the clear paste that concentration is 1g/ml, adds 95% ethanol and makes alcohol content be 70%, filters, collecting precipitation, dry, for subsequent use.
(3) Herba Taraxaci, Flos Lonicerae two kinds of medical materials are decocted with water secondary, first time adds 20 times of water gagings, second time adds 15 times of water gagings, each decoction 1 hour, collecting decoction and above-mentioned steps 1 filtrate, filter, it is 1.10 ~ 1.15 (60 DEG C) that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, cold preservation more than 24 hours, filter, filtrate reduced in volume, to without alcohol, adds above-mentioned volatile oil and Rhizoma Atractylodis Macrocephalae extract, adds purified water adjustment total amount to 1000ml, add appropriate antiseptic and solubilizing agent, stir, filter, embedding, sterilizing, to obtain final product.
Embodiment 2 oral liquid preparation of the present invention
Prescription: Herba Houttuyniae 300g, Radix Bupleuri 200g, Rhizoma Atractylodis Macrocephalae 300g, Herba Taraxaci 100g, Flos Lonicerae 100g.
Preparation technology: with the preparation technology of embodiment 1.
Embodiment 3 oral liquid preparation of the present invention
Prescription: Herba Houttuyniae 400g, Radix Bupleuri 100g, Rhizoma Atractylodis Macrocephalae 300g, Herba Taraxaci 100g, Flos Lonicerae 100g.
Preparation technology: with the preparation technology of embodiment 1.
Embodiment 4 oral liquid preparation of the present invention
Prescription: Herba Houttuyniae 300g, Radix Bupleuri 200g, Herba Taraxaci 100g, Flos Lonicerae 100g.
Preparation technology:
(1) get Herba Houttuyniae, Radix Bupleuri, add 30 times amount water distillation and extraction 6 hours, collect volatile oil and filtrate, for subsequent use.
(2) Herba Taraxaci, Flos Lonicerae two kinds of medical materials are decocted with water secondary, first time adds 20 times of water gagings, second time adds 15 times of water gagings, each decoction 1 hour, collecting decoction and above-mentioned steps 1 filtrate, filter, it is 1.10 ~ 1.15 (60 DEG C) that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, cold preservation more than 24 hours, filter, filtrate reduced in volume, to without alcohol, adds above-mentioned volatile oil, adds purified water adjustment total amount to 1000ml, add appropriate antiseptic and solubilizing agent, stir, filter, embedding, sterilizing, to obtain final product.
Embodiment 5 powder preparation of the present invention
Prescription: Herba Houttuyniae 200g, Radix Bupleuri 100g, Rhizoma Atractylodis Macrocephalae 200g, Herba Taraxaci 100g, Flos Lonicerae 100g.
Preparation technology:
Get above four Chinese medicine material, put in Universalpulverizer and pulverize, cross No. five sieves, add supplementary product starch to 1000g, mix homogeneously, subpackage, to obtain final product.
Below by way of the concrete test of pesticide effectiveness, beneficial effect of the present invention is described.
Test example 1 herbal medicine of the present invention is to the therapeutical effect of infectious bronchitis of chicken
1, trial drug
Sample 1: the medicine prepared according to embodiment 1
Sample 2: the medicine prepared according to embodiment 2
Sample 3: the medicine prepared according to embodiment 3
Sample 4: the medicine prepared according to embodiment 4
Sample 5: the medicine prepared according to embodiment 5
2, experimental animal is selected and grouping
Choose in clinical 30 ages in days, the symptoms such as performance rhinorrhea, dyspnea, sneeze, are diagnosed as the chickling of infectious bronchitis of chicken as clinical trial object, amount to 350, be divided into 7 groups, often organize 50, be respectively 1,2,3,4,5 groups, sample, positive drug group and blank group.
3, medication and dosage
1,2,3,4,5 groups, sample respectively spice gives corresponding pharmaceutical composition (daily amount is by 5g medical material/kg body weight), positive drug group gives tylosin Drug therapy (daily amount is 0.01g/kg body weight), and blank group does not give any Drug therapy.Successive administration 7 days.
4, test index and method
Respectively at during administration and administration complete after in 7 days, observe clinical symptoms and the Cure of each group of ill chicken, the indexs such as statistical analysis cure rate, mortality rate.
5, result of the test and analysis
In table 1.
Table 1 present composition is to the clinical test results of infectious bronchitis of chicken therapeutical effect
As shown in Table 1, matched group mortality rate is 24%, and the mortality rate of positive drug group is 12%, the mortality rate that administration is 1,2,3,5 groups reduces greatly, all remain on less than 10%, have the curative effect of significant treatment infectious avian bronchitis, curative effect is better than positive drug group; Sample 4 groups of curative effects are close with the effect of positive drug group curative effect, all have the curative effect of certain treatment infectious avian bronchitis.In 5 groups of samples, the curative effect that sample is 2 groups is best, can reach 98% to the cure rate of infectious avian bronchitis.
In his-and-hers watches, data carry out X 2 test, result shows, administration 1,5 groups is compared with matched group, there is significant difference (P<0.05), administration 2,3 groups is compared with matched group, there is pole significant difference (P<0.01), optimum with the curative effect of administration 2 groups.
Test example 2 herbal medicine of the present invention is to the therapeutical effect of infectious bursal disease
1, trial drug
Sample 1: the medicine prepared according to embodiment 1
Sample 2: the medicine prepared according to embodiment 2
Sample 3: the medicine prepared according to embodiment 3
Sample 4: the medicine prepared according to embodiment 4
Sample 5: the medicine prepared according to embodiment 5
2, experimental animal is selected and grouping
Choose clinical 3-6 age in week, performance spirit is depressed, appetite declines, feather is fluffy, arrange white loose stool, the symptoms such as even collapse is dead, be diagnosed as the chicken of infectious bursal disease as clinical trial object, amount to 350, be divided into 7 groups, often organize 50, be respectively 1,2,3,4,5 groups, sample, positive drug group and blank group.
3, medication and dosage
1,2,3,4,5 groups, sample respectively spice gives corresponding pharmaceutical composition (daily amount is by 5g medical material/kg body weight), positive drug group gives tylosin Drug therapy (daily amount is 0.01g/kg body weight), and blank group does not give any Drug therapy.Successive administration 7 days.
4, test index and method
Respectively at during administration and administration complete after in 7 days, observe clinical symptoms and the Cure of each group of ill chicken, the indexs such as statistical analysis cure rate, mortality rate.
5, result of the test and analysis
In table 2.
Table 2 present composition is to the clinical test results of infectious bursal disease therapeutical effect
As shown in Table 2, matched group mortality rate is 52%, and the mortality rate of positive drug group is 28%, and the mortality rate that administration is 1,2,3,5 groups reduces greatly, and have the curative effect of significant treatment infectious bursal disease, curative effect is better than positive drug group; Sample 4 groups of curative effects are close with the effect of positive drug group curative effect, all have the curative effect of certain treatment infectious bursal disease.In 5 groups of samples, the curative effect that sample is 2,3 groups is best, can reach 92% to the cure rate of infectious bursal disease.
In his-and-hers watches, data carry out X 2 test, result shows, positive drug group, administration 4 groups are compared with matched group, there is significant difference (P<0.05), administration 1,2,3,5 groups is compared with matched group, there is pole significant difference (P<0.01), optimum with the curative effect of administration 2,3 groups.
In sum, Chinese veterinary medicinal composition compatibility of the present invention is reasonable, evident in efficacy to treatment infectious bronchitis of chicken, infectious bursal disease, there is the effect of preventing and treating respiratory disease of chicken widely, for veterinary clinic provides a kind of component medicament selection simple, with low cost.
Claims (10)
1. treat a Chinese veterinary medicinal composition for respiratory disease of chicken, it is characterized in that: it is the preparation that the crude drug containing following weight proportioning is prepared from:
Herba Houttuyniae 2-5 part, Radix Bupleuri 1-3 part, Herba Taraxaci 1-3 part, Flos Lonicerae 1-3 part.
2. Chinese veterinary medicinal composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 3 parts, Radix Bupleuri 2 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part.
3. Chinese veterinary medicinal composition according to claim 1, is characterized in that: containing the Rhizoma Atractylodis Macrocephalae in described crude drug, its weight proportion is: Rhizoma Atractylodis Macrocephalae 2-5 part.
4. Chinese veterinary medicinal composition according to claim 3, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 2-5 part, Radix Bupleuri 1-3 part, Rhizoma Atractylodis Macrocephalae 2-5 part, Herba Taraxaci 1-3 part, Flos Lonicerae 1-3 part.
5. Chinese veterinary medicinal composition according to claim 4, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Herba Houttuyniae 2 parts, Radix Bupleuri 1 part, the Rhizoma Atractylodis Macrocephalae 2 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part; Or
Herba Houttuyniae 3 parts, Radix Bupleuri 2 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part; Or
Herba Houttuyniae 4 parts, Radix Bupleuri 1 part, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Taraxaci 1 part, Flos Lonicerae 1 part.
6. the Chinese veterinary medicinal composition according to claim 1-5 any one, it is characterized in that: it is active component by the protogenic medicinal powder of described crude drug or water or extractive with organic solvent, add the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
7. Chinese veterinary medicinal composition according to claim 6, is characterized in that: the dosage form of described oral formulations is tablet, unguentum, powder, decoction, pill, capsule, oral liquid.
8. the preparation method of Chinese veterinary medicinal composition described in claim 1 ~ 7 any one, is characterized in that: it comprises the steps:
A, take the crude drug of each weight proportion;
B, crude drug are beaten powder or are added water or organic solvent extraction, add the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
9. the preparation method of Chinese veterinary medicinal composition described in claim 3 ~ 7 any one, is characterized in that: it comprises the steps:
A, take the crude drug of each weight proportion;
B, get Herba Houttuyniae, Radix Bupleuri, extract volatile oil, filtrate is for subsequent use;
C, the Rhizoma Atractylodis Macrocephalae decoct with water extraction, are condensed into clear paste, add 95% ethanol and make alcohol content be 70%, filter, collecting precipitation, dry, for subsequent use;
D, get Herba Taraxaci, Flos Lonicerae decocts with water, decocting liquid and step b filtrate merge, filter, it is 1.10 ~ 1.15 (60 DEG C) that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, cold preservation, filter, filtrate reduced in volume to without alcohol, adds volatile oil prepared by b step and Rhizoma Atractylodis Macrocephalae extract prepared by step c, adds the oral formulations that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
10. the purposes of Chinese veterinary medicinal composition described in claim 1 ~ 7 any one in the medicine of preparation treatment respiratory disease of chicken, wherein, described respiratory disease of chicken is infectious bronchitis of chicken, infectious bursal disease, chicken Marek's disease, newcastle disease and/or bird flu.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177559A (en) * | 2016-08-22 | 2016-12-07 | 牛金鹏 | A kind of herbal medicine preventing and treating chicken heat shock reaction |
| CN106421085A (en) * | 2016-10-27 | 2017-02-22 | 成都乾坤动物药业股份有限公司 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
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| CN1302638A (en) * | 2000-01-01 | 2001-07-11 | 同济医科大学附属同济医院 | Anti-infection Chinese medicine for clearing heat and detoxicating and its preparing process |
| CN101214311A (en) * | 2007-12-27 | 2008-07-09 | 四川兴华药业有限责任公司 | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof |
| JP2008273846A (en) * | 2007-04-25 | 2008-11-13 | Yukito Akiyama | ADJUVANT AGAINST VIRUS- OR PATHOGENIC BACTERIUM-DERIVED INACTIVATED ANTIGEN AND SECRETORY IgA ANTIBODY INDUCER |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302638A (en) * | 2000-01-01 | 2001-07-11 | 同济医科大学附属同济医院 | Anti-infection Chinese medicine for clearing heat and detoxicating and its preparing process |
| JP2008273846A (en) * | 2007-04-25 | 2008-11-13 | Yukito Akiyama | ADJUVANT AGAINST VIRUS- OR PATHOGENIC BACTERIUM-DERIVED INACTIVATED ANTIGEN AND SECRETORY IgA ANTIBODY INDUCER |
| CN101214311A (en) * | 2007-12-27 | 2008-07-09 | 四川兴华药业有限责任公司 | Compound scutellaria injection for treating fowls and domestic animals infectious disease and preparation thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177559A (en) * | 2016-08-22 | 2016-12-07 | 牛金鹏 | A kind of herbal medicine preventing and treating chicken heat shock reaction |
| CN106421085A (en) * | 2016-10-27 | 2017-02-22 | 成都乾坤动物药业股份有限公司 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
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Address after: No. 259, Middle Section of Jinfu Road, Wenjiang District, Chengdu City, Sichuan Province, 611130 Patentee after: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL CO.,LTD. Address before: 611130 no.259 Jinfu Road, Chengdu cross strait science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee before: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL Co.,Ltd. |