CN104815007B - A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application - Google Patents
A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application Download PDFInfo
- Publication number
- CN104815007B CN104815007B CN201510243344.XA CN201510243344A CN104815007B CN 104815007 B CN104815007 B CN 104815007B CN 201510243344 A CN201510243344 A CN 201510243344A CN 104815007 B CN104815007 B CN 104815007B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- rhizoma atractylodis
- atractylodis macrocephalae
- forsythia suspense
- skullcap root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active - Reinstated
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of pharmaceutical compositions for preventing infectious bronchitis of chicken and preparation method thereof.The pharmaceutical composition is that the bulk pharmaceutical chemicals matched by following weight are prepared：13 parts of Baical Skullcap root P.E, 13 parts of forsythia suspense extraction, 10 30 parts of Rhizoma Atractylodis Macrocephalae.Preparation method is：A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；B. Rhizoma Atractylodis Macrocephalae is taken, adds water to cook extraction, is filtered, is concentrated, it is dry, it is spare；C. by Baical Skullcap root P.E, forsythia suspense extraction and Rhizoma Atractylodis Macrocephalae extract after mixing, add in pharmaceutically acceptable auxiliary material or complementary ingredient is prepared into pharmaceutically common preparation.The present invention also provides purposes of the pharmaceutical composition in the drug for preparing prevention infectious bronchitis of chicken.Pharmaceutical composition prepared by the present invention is compared with the common antiviral and antibacterials of clinic, and significant in efficacy, cure rate reaches 98%, and a kind of pharmaceutical composition of completely new treatment infectious bronchitis of chicken is provided for veterinary clinic.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for preventing infectious bronchitis of chicken and its preparation method and application, belong to medicine
Object field.
Background technology
Infectious bronchitis of chicken (Infectious bronchitis, IB) is by infectious bronchitis virus
The viral disease that a kind of acute, high degree in contact of chicken caused by (Infectious bronchitisvirus, IBV) infects
Disease.Infected chicken clinical symptoms show as cough, sneeze, tracheae rale, price of deed decline, productivity forfeiture, death rate increase
Deng.Laying hen infects this after being ill, and egg production substantially reduces, and protein quality declines fairly obvious.The disease is to seriously endanger the world to support
One of serious infectious diseases of fowl industry, this disease is popular throughout the year, but the most serious with Winter-Spring cold season, and the disease has been spread at present
To national most area, huge economic loss is caused to poultry husbandry.Since the serotype of IBV is more, variation is fast, each poison
Strain Virulence Difference is big, and cross-protection is low between strain, and larger difficulty is brought to the preventing and controlling of the disease.
The treatment of the disease at present is mostly treated using biochemical drugs such as interferon, immunoglobulin, immune ribonucleic acids,
There are price costly, the shortcomings of curative effect is not notable.In recent years, cheap, eutherapeutic Chinese medicine treatment is explored to pass
Metachromia bronchitis is increasingly paid attention to by veterinary clinic, is such as somebody's turn to do using with clearing heat and detoxicating and relieving cough and reducing sputum Chinese medicine
The treatment of disease, achieves the effect of certain.
Radix scutellariae, Fructus Forsythiae have effects that clearing heat and detoxicating, and Rhizoma Atractylodis Macrocephalae has effects that invigorating the spleen and eliminating dampness, clinically for treating poultry
The diseases such as fowl warm disease heating, cough with lung heat.It is existing prevention infectious bronchitis of chicken pharmaceutical composition be mostly comprising radix scutellariae,
The big prescription of one or both of three kinds of Fructus Forsythiae, Rhizoma Atractylodis Macrocephalae primary crude drugs, there has been no with Baical Skullcap root P.E, forsythia suspense extraction and white
Pharmaceutical composition of the art for the prevention infectious bronchitis of chicken of prescription.
Invention content
The technical scheme is that provide a kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation
Method and purposes.
The present invention provides a kind of pharmaceutical compositions for preventing infectious bronchitis of chicken, it is matched by following weight
Raw material is prepared：
1-3 parts of Baical Skullcap root P.E, 1-3 parts of forsythia suspense extraction, 10-30 parts of Rhizoma Atractylodis Macrocephalae.
Wherein, in Baical Skullcap root P.E 85.0% is no less than containing scutelloside；It is no less than in forsythia suspense extraction containing forsythiaside A
6.0%, forsythin is no less than 0.5%.
Preferably, the weight proportion of raw material is：
1 part of Baical Skullcap root P.E, 2 parts of forsythia suspense extraction, 10 parts of Rhizoma Atractylodis Macrocephalae.
Pharmaceutical composition prepared by the present invention is primary medicinal powder, water or the extractive with organic solvent by Rhizoma Atractylodis Macrocephalae, adds in radix scutellariae
Extract and forsythia suspense extraction add in pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically as active constituent
Common preparation.
Wherein, the preparation is decoction, powder, granule, mixture, tablet or capsule.
The present invention also provides a kind of methods for preparing the pharmaceutical composition, it includes the following steps：
A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；
B. Rhizoma Atractylodis Macrocephalae is taken, adds 20 times to measure water boiling and extraction 3 times, 1.5 hours every time, filtering, filtrate concentration was depressurized dry
It is dry, it is spare；
C. the Rhizoma Atractylodis Macrocephalae extract obtained Baical Skullcap root P.E, forsythia suspense extraction and step b after mixing, adds in pharmaceutically
Acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
The present invention also provides purposes of the pharmaceutical composition in the drug for preparing prevention infectious bronchitis of chicken.
Three kinds of Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae drugs are combined to treat avian infectious branch by the present invention
Tracheitis, compared with the common antiviral and antibacterials of clinic, significant in efficacy, cure rate reaches 98%, is provided for veterinary clinic
A kind of pharmaceutical composition of completely new treatment infectious bronchitis of chicken.
Below by way of specific embodiment, the present invention is described in further detail, but is not intended to limit the present invention, ability
Field technique personnel, without departing from the spirit of the present invention, should all belong to this hair according to the various changes of the invention made and replacement
Bright scope of the appended claims.
Specific embodiment
The preparation of 1 pharmaceutical composition of the present invention of embodiment
Raw material is weighed according to following weight proportioning：
Baical Skullcap root P.E 1g, forsythia suspense extraction 1g, Rhizoma Atractylodis Macrocephalae 10g；
Preparation method：
A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；
B. Rhizoma Atractylodis Macrocephalae is taken, adds 20 times to measure water boiling and extraction 3 times, 1.5 hours every time, filtering, filtrate concentration was depressurized dry
It is dry, it is spare.
C. the obtained Rhizoma Atractylodis Macrocephalae extract of Baical Skullcap root P.E, forsythia suspense extraction and step b is added into starch extremely after mixing
100g, be uniformly mixed, pack to get.
The preparation of 2 pharmaceutical composition of the present invention of embodiment
Raw material is weighed according to following weight proportioning：
Baical Skullcap root P.E 1g, forsythia suspense extraction 1g, Rhizoma Atractylodis Macrocephalae 20g；
The preparation method is the same as that of Example 1.
The preparation of 3 pharmaceutical composition of the present invention of embodiment
Raw material is weighed according to following weight proportioning：
Baical Skullcap root P.E 1g, forsythia suspense extraction 2g, Rhizoma Atractylodis Macrocephalae 10g；
The preparation method is the same as that of Example 1.
The preparation of 4 pharmaceutical composition of the present invention of embodiment
Raw material is weighed according to following weight proportioning：
Baical Skullcap root P.E 1g, forsythia suspense extraction 2g, Rhizoma Atractylodis Macrocephalae 10g；
Preparation method：
A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；
B. Rhizoma Atractylodis Macrocephalae is taken, adds 20 times to measure water boiling and extraction 3 times, 1.5 hours every time, filtering, filtrate concentrated, and medicinal extract is standby
With；
C. the Rhizoma Atractylodis Macrocephalae medicinal extract obtained Baical Skullcap root P.E, forsythia suspense extraction and step b after mixing, adds purified water constant volume
To 100ml, be uniformly mixed, add in 0.2% sodium benzoate, adjustings pH value is 6.5-7.0, is packed, sterilize to get.
Above-mentioned Baical Skullcap root P.E, forsythia suspense extraction are pressed《Republic of China Veterinary Pharmacopoeia》2010 editions second radix scutellariae extractions
The standard preparation of object, forsythia suspense extraction.
Beneficial effects of the present invention are proved below by way of specific experiment.
1 medical treatment infectious bronchitis of chicken clinical verification of the present invention of experimental example is tested
(1) experimental drug
The drug that sample 1 is prepared according to embodiment 1
The drug that sample 2 is prepared according to embodiment 2
The drug that sample 3 is prepared according to embodiment 3
The drug that sample 4 is prepared according to embodiment 4
(2) experimental animal selection and grouping
It chooses in clinical 30 ages in days, the symptoms such as performance rhinorrhea, expiratory dyspnea, sneeze are diagnosed as avian infectious bronchus
Scorching chick is as clinical test object, 300 altogether, is divided into 6 groups, every group 50, respectively sample 1,2,3,4 groups, the positive
Medicine group and blank control group.
(3) medication and dosage
Sample 1,2,3,4 groups respectively spice give corresponding drug (daily dose be calculated as 0.01g/ with Baical Skullcap root P.E
Kg weight), positive drug group gives tylosin drug therapy (daily dose is 0.01g/kg weight), and blank control group is not
Give any drug therapy, successive administration 7 days.
(4) test index and method
During administration and after the completion of administration in 7 days, the clinical symptoms and Cure of each group illness chicken, system are observed
The indexs such as meter analysis cure rate, the death rate.
(5) result of the test and analysis
1 clinicing symptom observation result of table
By clinicing symptom observation result it is found that the control group rhinorrhea of chick, breathing in non-administration, group is tired
It is 13 days that the diseases of the respiratory symptoms such as hardly possible, sneeze, which continues the time, gives the respiratory symptom disease after tylosin treatment and continues the time and is
10 days, and give respiratory symptom disease after sample 1-4 groups and continue the time and substantially reduce, it concentrates on 6-7 days or so, illustrates sample 1-4
Group is respectively provided with the apparent effect for alleviating infectious avian bronchitis acute attack symptom, and curative effect is better than positive drug group.
2 clinical test results of table
By clinical verification result of the test it is found that the control group death rate is 22%, the death rate of positive drug group is 12%, sample
The death rate of product 1-4 groups substantially reduces, and protects disease 5% hereinafter, being respectively provided with significant treatment infectious avian bronchitis
Curative effect, curative effect are better than positive drug group.Chi-square Test is carried out to data in table, the results showed that, positive drug group and control group phase
Than significant difference (P<0.05), be administered sample 1,2,3,4 groups compared with the control group, have pole significant difference (P<0.01),
The effect of 3,4 groups of sample is administered, is optimal, to the cure rate of infectious avian bronchitis up to 98%.Wherein, in bulk pharmaceutical chemicals
Weight proportion is：1 part of Baical Skullcap root P.E, 2 parts of forsythia suspense extraction, the drug effect of 10 parts of Rhizoma Atractylodis Macrocephalae are best.
Claims (7)
1. a kind of pharmaceutical composition for preventing infectious bronchitis of chicken, it is characterised in that：It is the original matched by following weight
Material medicine is prepared：
1-3 parts of Baical Skullcap root P.E, 1-3 parts of forsythia suspense extraction, 10-30 parts of Rhizoma Atractylodis Macrocephalae；
Wherein, in Baical Skullcap root P.E 85.0% is no less than containing scutelloside；It is no less than in forsythia suspense extraction containing forsythiaside A
6.0%, forsythin is no less than 0.5%；
The pharmaceutical composition is prepared, is included the following steps：
A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；
B. Rhizoma Atractylodis Macrocephalae is taken, extracting in water filters, and concentration is dried under reduced pressure, spare；
C. after mixing, addition can pharmaceutically connect the Rhizoma Atractylodis Macrocephalae extract obtained Baical Skullcap root P.E, forsythia suspense extraction and step b
The auxiliary material or complementary ingredient received are prepared into pharmaceutically common preparation.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals that following weight matches
It forms：
1 part of Baical Skullcap root P.E, 2 parts of forsythia suspense extraction, 10 parts of Rhizoma Atractylodis Macrocephalae.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that：It is the water extract by Rhizoma Atractylodis Macrocephalae, is added in yellow
A kind of reed mentioned in ancient books extract and forsythia suspense extraction add in pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmacy as active constituent
Upper common preparation.
4. pharmaceutical composition according to claim 1 or 2, it is characterised in that：The preparation is decoction, powder, particle
Agent, mixture, tablet or capsule.
5. pharmaceutical composition according to claim 3, it is characterised in that：The preparation for decoction, powder, granule,
Mixture, tablet or capsule.
6. preparing the method for the pharmaceutical composition described in claim 1-5 any one, it includes the following steps：
A. the Baical Skullcap root P.E, forsythia suspense extraction, Rhizoma Atractylodis Macrocephalae of each weight proportion are weighed；
B. Rhizoma Atractylodis Macrocephalae is taken, extracting in water filters, and concentration is dried under reduced pressure, spare；
C. after mixing, addition can pharmaceutically connect the Rhizoma Atractylodis Macrocephalae extract obtained Baical Skullcap root P.E, forsythia suspense extraction and step b
The auxiliary material or complementary ingredient received are prepared into pharmaceutically common preparation.
7. the pharmaceutical composition described in claim 1-5 any one is in the drug for preparing prevention infectious bronchitis of chicken
Purposes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510243344.XA CN104815007B (en) | 2015-05-13 | 2015-05-13 | A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510243344.XA CN104815007B (en) | 2015-05-13 | 2015-05-13 | A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104815007A CN104815007A (en) | 2015-08-05 |
| CN104815007B true CN104815007B (en) | 2018-06-26 |
Family
ID=53725651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510243344.XA Active - Reinstated CN104815007B (en) | 2015-05-13 | 2015-05-13 | A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104815007B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309761A (en) * | 2016-08-30 | 2017-01-11 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for treating avian infectious broncheitis and preparation method of microcapsules of pharmaceutical composition |
| CN106377610A (en) * | 2016-11-21 | 2017-02-08 | 成都乾坤动物药业股份有限公司 | Pharmaceutical composition for preventing and treating livestock/poultry virus diseases and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069545C (en) * | 1996-01-09 | 2001-08-15 | 李宏 | The antibacterial and antiviral drug composition and method of making the same |
| CN102988490A (en) * | 2012-11-26 | 2013-03-27 | 河南新正好生物工程有限公司 | Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032876C (en) * | 1991-08-12 | 1996-09-25 | 兖州矿务局科研所 | Anti-deformation of movable house used on high phreatic water collapse area |
| KR101474125B1 (en) * | 2013-05-02 | 2014-12-18 | 동국대학교 경주캠퍼스 산학협력단 | Composition comprising complex extract of Astragalus membranaceus BUNGE, Saposhnikovia divaricata Schiskin, Ostericum koreanum Maximowicz, Scutellaria baicalensis Georgi and Atractylodes japonica Koidz for preventing or treating asthma, bronchitis or pneumonia |
-
2015
- 2015-05-13 CN CN201510243344.XA patent/CN104815007B/en active Active - Reinstated
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069545C (en) * | 1996-01-09 | 2001-08-15 | 李宏 | The antibacterial and antiviral drug composition and method of making the same |
| CN102988490A (en) * | 2012-11-26 | 2013-03-27 | 河南新正好生物工程有限公司 | Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis |
Non-Patent Citations (3)
| Title |
|---|
| 白术粗多糖对湘黄鸡生长性能的影响;文贵辉等;《饲料研究》;20111231(第12期);第17-19页，尤其是第17页左栏第1段 * |
| 连翘酯苷的生物学功能及其在鸡生产中的应用;代重山;《中国饲料》;20141231(第20期);第12-14、18页，尤其是第14页左栏最后1段 * |
| 黄芩有效成分提取及对传染性支气管炎预防效果的研究;王秋菊等;《饲料博览》;20091231(第12期);第34-36页，尤其是第35页左栏第1段，第36页右栏第6-12行 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104815007A (en) | 2015-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101559095B (en) | Veterinary compound acanthopanax granules with immunopotentiation and preparation method thereof | |
| CN104257704B (en) | The new application of Eurycoma longifolia extract product | |
| CN104208163B (en) | It is a kind of improve animal immunizing power Chinese veterinary medicinal composition, using and preparation method thereof | |
| CN105617354A (en) | Medicine for treating rheumatism and rheumatoid | |
| CN104815007B (en) | A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application | |
| CN103417884B (en) | Drug for treating chicken airsacculitis and preparation method of drug | |
| CN103751274A (en) | Pharmaceutical composition for treating duck and goose flavivirus infection and preparation method thereof | |
| CN101259160A (en) | Compound preparations for treating birdsvirosis and preparation thereof | |
| CN104784327B (en) | A kind of Chinese veterinary medicinal composition for treating chicken respiratory tract disease and preparation method thereof | |
| CN106389562A (en) | Pudilan Xiaoyan granules, preparation method thereof, and product quality control method | |
| CN102813713A (en) | Rhizoma dryopteris crassirhizomae and fructus crataegi composition, preparation method and application of composition | |
| CN106421447A (en) | Medicine composition for controlling blood pressure and protecting blood vessels and preparation method and purpose thereof | |
| CN101502536B (en) | Cedar total flavone as well as preparation method and medical use | |
| CN109432390A (en) | A kind of Chinese medicine peptide for infectious laryngotracheitis of chicken, drug and preparation method thereof | |
| CN105816583B (en) | Compound medicine for treating cold and preparation method thereof | |
| CN1191086C (en) | Medicine for treating cold in summer and autumn | |
| CN105748861A (en) | Traditional Chinese medicine composition for resisting stress reaction, and preparation method and application thereof | |
| CN115607596B (en) | Health wine with uric acid reducing effect and preparation method thereof | |
| CN102552600A (en) | Traditional Chinese medicine for preventing and treating chicken infectious laryngotracheitis and production method thereof | |
| CN107496476A (en) | The beneficial liver effect of yunna cowparsnip and application technology | |
| CN111773258B (en) | Mongolian medicine for resisting influenza virus, pharmaceutical composition, preparation method and application thereof | |
| CN101711795A (en) | Veterinary antipyretic and antiviral medicine composite | |
| CN106265914A (en) | A kind of for preventing and treating because of high temperature, the high humidity Chinese medicine composition causing chicken disease and preparation method thereof | |
| CN106860689B (en) | Traditional Chinese medicine compound preparation for preventing and treating egg drop syndrome of chickens and preparation method thereof | |
| CN109432370A (en) | A kind of Chinese medicine and preparation method thereof for treating capon respiratory disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180626 Termination date: 20190513 |
|
| RR01 | Reinstatement of patent right | ||
| RR01 | Reinstatement of patent right |
Former decision: termination of patent right due to unpaid annual fee Former decision publication date: 20200501 |
|
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: No. 259, Middle Section of Jinfu Road, Wenjiang District, Chengdu City, Sichuan Province, 611130 Patentee after: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL CO.,LTD. Address before: 611130 no.259 Jinfu Road, Chengdu cross strait science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee before: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL Co.,Ltd. |