CN107496485A - The beneficial liver effect of pilose gerbera herb and application technology - Google Patents
The beneficial liver effect of pilose gerbera herb and application technology Download PDFInfo
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- CN107496485A CN107496485A CN201710903687.3A CN201710903687A CN107496485A CN 107496485 A CN107496485 A CN 107496485A CN 201710903687 A CN201710903687 A CN 201710903687A CN 107496485 A CN107496485 A CN 107496485A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L23/00—Soups; Sauces; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
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- Nutrition Science (AREA)
- Biotechnology (AREA)
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- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
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- Zoology (AREA)
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Abstract
The invention discloses purposes of the pilose gerbera herb in beneficial liver effect product is prepared.Using the pilose gerbera herb herb of feverfew as raw material, all kinds of high-quality beneficial liver products, including the edible health product of human and animal, herbal cuisine and natural drug product and herbal cuisine product can be effectively converted to by extraction process and processing technology.
Description
Technical field
The present invention relates to the process technology of the plant pilose gerbera herb acted on beneficial liver and in food, health food, day
Purposes in right medicine, animal health products and veterinary drug, is dry pilose gerbera herb herb, deep processing and extract specifically
The use of preparation method, deep processed product, active chemical, pilose gerbera herb herb in liver-protecting efficacy health products and herbal cuisine is prepared
On the way, the application of application and animal benefit liver product of the pilose gerbera herb herb in the medicine for preparing hepatitis.
Background technology
Everyone is required for liver health care.Liver is one of most important Functional tissue, liver in human and animal's body
Cell subjects substantial amounts of biochemistry treatment and processing work daily, and the food and feed largely absorbed through alimentary canal is entered
The various processing metabolism of row, are very easy to fatigue and by various pathogenic former damages.Hepar damnification is to seriously endanger the people
The disease of health, and the hepatic injury being currently known causes a disease original with thousands of kinds.China has more than the hepatitis B of 100,000,000 people at present
Lifelong carrier, the carrier of tens million of HCVs.In recent years as being addicted to drink, caused by medicine and various adverse factors
Poisoning hepar damnification also increases increasingly.Tens of millions of people can be transformed into chronic hepatitis, hepatic sclerosis, liver cancer in hepatopath, every year
Because of hepatopathy, dead people there are about hundreds of thousands of them.It is Chinese to be used to treat the costly up to tens billion of yuans of hepatopathy every year, it is right
Economy and the physical and mental health of social development particularly patient cause very big burden, so keeping the health of liver turns into people
The target of pursuit.Food and herbal cuisine, the health food and new drug that exploitation is beneficial to liver health are just very urgent.
Pilose gerbera herb [Gerbera piloselloides (L.) Cass]:For feverfew, also referred to as radix cynanchi atrati, white-browed, hoary hair
Father-in-law etc..Pilose gerbera herb is the Yamoniang of minority area of Southwest China, the Shui nationality, the Dong nationality, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, the She, Jingpo Nationality, A'chang nationality
There are the history used in race, De'ang nationality, the Dai nationality, Hani, Bai nationality, Zhuang, the Dong nationality etc..Herb is the use portion of pilose gerbera herb
Position.Pilose gerbera herb relieves inflammation or internal heat anti-inflammatory and other effects.Cure cold, cure mainly productive cough, pertussis, seasonal febrile diseases, stomach trouble, rush down dysentery, hemorrhoid hemorrhage, tooth
Bitterly, cold, heat is not moved back long, extremities joint gives birth to sore, postpartum dysphoria and acute conjunctivitis etc..The present invention is exactly to be found that hair is big
Liver protection new application of the fourth grass herb in edible, food, health food, herbal cuisine and medicine, processing method and contain effective
Composition etc..
The content of the invention
It is an object of the invention to provide the new application of pilose gerbera herb herb, that is, is preparing hepatitis treatment medicine, health food
With the new opplication in animal benefit liver product.
It is a further object of the present invention to provide a kind of natural national medicine of hepatitis treatment.
It is also another object of the present invention to provide a kind of health food of hepatitis auxiliary treatment.
The purpose of the present invention also includes providing the pilose gerbera herb extract and its system that preparation is convenient, health care and therapeutic effect are good
Preparation Method.
Inventor has carried out substantial amounts of deep processing to pilose gerbera herb herb according to the processing method of Chinese medicine and studied, including hair
Gerbera herb medicine materical crude slice, pilose gerbera herb herb powder, pilose gerbera herb herb wine, pilose gerbera herb herb meat soup, pilose gerbera herb herb sense
Emit herbal cuisine soup, pilose gerbera herb herb liver toxin expelling herbal cuisine soup, pilose gerbera herb herb extract etc..
Inventor's reference《2003 annual drug research technological guidance principle-Chinese medicines, natural goods fascicle》(state food medicine
Product Surveillance Authority 2003),《New drug preclinical study guideline》(national Bureau of Drugs Supervision 1993) and《Health food work(
Assessment process can be learned》The drug evaluation method and health food evaluation method of the hepatitis treatment of (Ministry of Public Health 2003) etc. are right
Pilose gerbera herb has carried out extract preparation, pharmaceutical dosage form preparation, animal pharmacology and pathological study.
The preparation method of pilose gerbera herb herb extract is:Pilose gerbera herb herb 1000g can be taken, is added water to cook three times,
15 minutes every time, collecting decoction, filtration, after filtrate is concentrated and dried (sprayable drying), fine powder processed, produce.This product is brown
Particle.
Inventor has found, is administered orally with pilose gerbera herb extract and drug administration by injection, there is obvious effect, serum
Liver biochemistry functional parameter and pathological index all improve significantly.
When being treated with pilose gerbera herb extract, it can be with pulvis, granule, tablet, capsule, pill and liquid medicine
The forms such as agent are administered orally;Can also in the form of parenteral solution, suppository, percutaneous preparation, spray etc. parenteral administration.Pilose gerbera herb
The effective agent of extract, it is by being mixed with appropriate medicinal blend, such as excipient, adhesive, bleeding agent, lubricant
And it is configured to.
Pilose gerbera herb extract doses change with route of administration, the age of patient and body weight.In the case of oral administration,
Dosage is usually adult 200~500mg/ days, preferably 350mg/ days.It is in terms of health food and food applications and same
Principle.
It is an advantage of the invention that:The beneficial liver therapeutic action of pilose gerbera herb is all at home and in the world to find first.Mao great
Fourth grass can be as the natural drug for the treatment of hepatitis.
In addition, pilose gerbera herb preparation method is fairly simple, also comparing for plant growth the characteristic study is thorough, so material
Source and economy are all secure.The market recognition of natural products is higher, and the acceptance in market is high, good market prospect.
Embodiment
Examples provided below is used for that the present invention is furture elucidated, and is not meant to limit the scope of the invention.
The material of embodiment 1.
Pilose gerbera herb medicine materical crude slice used in embodiment is that pharmacy and medicinal material market Chinese medicine supplier buy.
Other medicines, reagent and experimental animal, can be easily purchased in market.
The preparation method example of embodiment 2.
Pilose gerbera herb medicine materical crude slice 1000g is taken, adds water 2500ml to decoct, altogether three times, 15 minutes every time, collecting decoction, is filtered, filter
Liquid is concentrated to dryness, and crushes to obtain brown fine powder.Can also be sprayed to obtain fine powder.
The example of formulations of embodiment 3.
(1) the pilose gerbera herb herb extract for taking the preparation method of 1kg embodiments 2 to obtain, add appropriate amount of starch and mix, system
For granule, dispensed after whole grain, every bag of 2g.
(2) the pilose gerbera herb extract 1000g that the preparation method of Example 2 obtains, hydroxyethyl cellulose 10g, tabletting
Tablet is made.
(3) the pilose gerbera herb herb extract that the preparation method of embodiment 2 obtains is dissolved in physiological saline or isotonic glucose
Liquid, after filtering on demand using the parenteral solution prepared.
(4) the pilose gerbera herb herb extract that the preparation method of embodiment 2 obtains is dissolved in water, can be formulated directly into oral
Liquid.
(5) the pilose gerbera herb herb extract that the preparation method of embodiment 2 obtains can be used alone.Can also and desert
The medicines such as beans extract, eryuelan extract, which coordinate, is made compound mixture for preventing and treating hepatitis.
(6) the pilose gerbera herb extract powder that the preparation method of embodiment 2 obtains mixes with other seasoning powders, can be direct
It is configured to herbal cuisine soup stock.
The beneficial liver effect experiment of embodiment 4.
(1) evaluation method
Pilose gerbera herb herb extract treats the drug efficacy study part of hepatitis
Experimental animal is adult healthy male CD-1 mouse.Enough running water and normal diet are provided during experiment.Will
Mouse is grouped at random by body weight.To be administered for three days on end in being observed in the effect of toxic hepatitis, once a day.Take blood within 4th day
With leave and take animal's liver, determine the liver function enzyme alanine transaminase (ALT) in serum, observe hepatic pathology intensity of variation.Experiment
Data are represented with mean ± standard deviation.The methods of being examined using EXCEL statistical softwares to experimental result using variance analysis, t point
Analysis is handled.
(2) evaluation result (Tables 1 and 2):Pilose gerbera herb has the beneficial liver effect of significant anti-toxic hepatitis.
The anti-paracetamol acute toxic hepatitis effect of the pilose gerbera herb of table 1
Note:* p ﹤ 0.01 compared with hepatitis group of being poisoned.
The effect of the anti-carbon tetrachloride poisoning hepatitis of the pilose gerbera herb extract of table 2
Note:* p ﹤ 0.01 compared with toxic hepatitis group.
Claims (7)
1. there is the plant product of beneficial liver effect for preparing to human and animal, it is characterised in that containing pilose gerbera herb or its carry
Take thing.
2. a kind of pilose gerbera herb extract, it is characterised in that prepare with the following method, take pilose gerbera herb, add water to cook three
It is secondary, 15 minutes every time, collecting decoction, filtration, after filtrate is concentrated and dried, fine powder is made.
3. pilose gerbera herb extract according to claim 2, it is characterised in that extract fine powder and appropriate medical dressing
A variety of formulations such as oral formulations, injection, granule, tablet, capsule, pill, powder can be made together.Can also and its
Its medicine or other plant extracts compatibilities composition compound preparation.
4. a kind of medicine for hepatitis preventing and treating, it is characterised in that contain the pilose gerbera herb described in claim 1 and 2 or extraction
Thing.
5. a kind of health products for beneficial liver, it is characterised in that contain the pilose gerbera herb or extract described in claim 1 and 2.
6. the answering in the medicine and health products for preparing hepatitis of the pilose gerbera herb or extract described in claim 1 and 2
With.
7. application of the pilose gerbera herb or extract described in claim 1 and 2 in herbal cuisine is prepared.
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CN108685964A (en) * | 2018-07-12 | 2018-10-23 | 贵州医科大学 | The application of pilose gerbera herb extract and its active principle preparation method |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108685964A (en) * | 2018-07-12 | 2018-10-23 | 贵州医科大学 | The application of pilose gerbera herb extract and its active principle preparation method |
CN108685964B (en) * | 2018-07-12 | 2021-06-18 | 贵州医科大学 | Application of gerbera piloselloides extract and preparation method of active ingredients of gerbera piloselloides extract |
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Application publication date: 20171222 |