CN1284553C - Application of five-finger fig in preparing adjuvant for treating hepatitis and health foods - Google Patents
Application of five-finger fig in preparing adjuvant for treating hepatitis and health foods Download PDFInfo
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- CN1284553C CN1284553C CN 200510002111 CN200510002111A CN1284553C CN 1284553 C CN1284553 C CN 1284553C CN 200510002111 CN200510002111 CN 200510002111 CN 200510002111 A CN200510002111 A CN 200510002111A CN 1284553 C CN1284553 C CN 1284553C
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Abstract
The present invention discloses a new application of five-finger fig in the preparation of adjuvant therapy medicines for hepatitis and health-care food. The present invention relates to an extract of five-finger fig and a preparation method thereof. The medicine or the health-care food with the five-finger fig extract as an active ingredient can effectively treat acetaminophen toxic hepatitis, carbon tetrachloride toxic hepatitis and cocaine toxic hepatitis. The five-finger fig is a plant which can be used as the medicine and the food and has high safety.
Description
Technical field
The present invention relates to the extraction of a kind of plant Herba Fici Simplicissimae medical material and in medicine, purposes in the health food, specifically, is Radix Fici Simplicissimae extract, method for preparing extractive and in the adjuvant therapy medicaments of preparation hepatitis or the purposes in the health food.
Background technology
In the middle of gastral disease, hepatopathy and gastric cancer are the disease kinds of serious harm people ' s health.China has 1.2 hundred million hepatitis B virus lifelong carriers at present approximately, and wherein 3,000 ten thousand people can be transformed into chronic hepatitis, liver cirrhosis, hepatocarcinoma, and annual people because of hepatopathy death has 300,000 people approximately.In recent years, along with improving constantly of living standards of the people, the fatty liver by being addicted to drink and causing with some other factor also increases day by day.China is used for the treatment of the expense of hepatopathy every year up to 40,000,000,000 yuans, and national economy and social development has been caused very big influence.Owing to still lack the method for specific treatment hepatitis at present, the new drug of exploitation treatment hepatopathy is very urgent and important.
Herba Fici Simplicissimae is on the books in 90-91 page or leaf of Pharmacopoeia of People's Republic of China version in 1977.Description to Herba Fici Simplicissimae is: " this product is the dry root of moraceae plants Herba Fici Simplicissimae Ficus simplicicissima Lour..All can excavate the whole year, removes fibrous root, cleans, and section is dried.[nature and flavor] are hot, sweet, flat.[function and cure mainly] invigorating the spleen and benefiting QI, removing dampness and relaxing myospasm.Be used for insufficiency of the spleen edema, spontaneous perspiration, chronic bronchitis, rheumatic arthralgia, lumbago.[usage and consumption] 15～30 grams.
Herba Fici Simplicissimae medical material plant has had the artificial culture base at present in southern growth distribution in Guangdong.In recent years, Herba Fici Simplicissimae has had some progress aspect edible.These from online some patents announced of State Patent Office as can be seen, these patents have " with Herba Fici Simplicissimae prepare extracting solution and with the method (number of patent application 98122218.8) of this liquid preparation of drinks, soup stock, method for preparing Wuzhi wild peach wine (number of patent application 99101657.2), a kind ofly prepare the method (number of patent application 00117384.7) of fragrant chicken and rapid reproducing and cultivating method for high-yield five-finger peach (number of patent application 99117055.5) etc. with the Herba Fici Simplicissimae Radix Fici Hirtae.
Since Herba Fici Simplicissimae medicinal and edible aspect application is all arranged, the function of in pharmacopeia, pointing out so, how to make the research and development of Herba Fici Simplicissimae scientific and seek its new medical value and health food and be worth and just become present problem demanding prompt solution.This is the new purposes of having found Herba Fici Simplicissimae treatment hepatitis for the present invention.
Summary of the invention
The new purposes that the purpose of this invention is to provide Herba Fici Simplicissimae, i.e. new application in preparation hepatitis adjuvant therapy medicaments and health food.
Another object of the present invention provides a kind of medicine of hepatitis auxiliary treatment.
A further object of the present invention provides a kind of health food of hepatitis auxiliary treatment.
Purpose of the present invention also comprises provides good Radix Fici Simplicissimae extract of easy to prepare, health care and therapeutic effect and preparation method thereof.
The inventor is according to " 2003 annual drug research technological guidance principle---Chinese medicine, natural goods fascicle " (State Food and Drug Administration, 2003), " new drug preclinical study guideline " (1993, Bureau of Drugs Supervision of country) and " health food function assessment assessment process " (Ministry of Public Health, 2003) etc. the medicine and the health food method of hepatitis auxiliary treatment, Herba Fici Simplicissimae has been carried out extract preparation, pharmaceutical dosage form preparation, animal pharmacology and pathological study.
The preparation method of Radix Fici Simplicissimae extract is: get Radix Fici Simplicissimae decoction pieces 1000g, pulverize, wash 3～4 times, decoct with water three times, each 15 minutes, collecting decoction filtered, and it is 1.12～1.25 thick paste that filtrate is condensed into relative density, after continuing drying, the system fine powder, promptly.This product is brown granule; Special fragrance, lightly seasoned sweet is arranged.
The inventor finds, carries out lumbar injection and oral administration with Radix Fici Simplicissimae extract, and obvious effects is all arranged, and serum liver biochemical function index and pathological index all improve significantly.
When treating with Radix Fici Simplicissimae extract, it can be with form oral administrations such as powder, granule, tablet, capsule, pill and liquid preparations; Also can be non-through enteral administration with forms such as injection, suppository, percutaneous preparation, sprays.The effective agent of Radix Fici Simplicissimae extract, be by with suitable medicinal blend, as mixing such as excipient, binding agent, penetrating agent, lubricants and be mixed with.
Radix Fici Simplicissimae extract dosage changes with patient's the state of an illness, route of administration, patient's age and body weight.Under the oral administration situation, dosage is generally adult 1000～3000mg/ days, is preferably 500～1000mg/ days.In the health food application facet also is same principle.
Aspect the safety of medicine and health food, we find the acute oral LD of Radix Fici Simplicissimae extract to mice
50＞24g/kg.So Radix Fici Simplicissimae extract belongs in fact nontoxic material basically, prompting is a kind of relatively material of safety.
Advantage of the present invention is: Herba Fici Simplicissimae can be used as the chemical compound of cocaine poisoning hepatitis auxiliary treatment.Cocaine is popular analeptic drugs in a kind of world wide.2002 the end of the year China major drug-related cases of 100 kilograms of cocaine smugglings have just taken place.Hepatitis is the lethal major reason of cocaine poisoning.Also do not treat at present the generally acknowledged medicine of cocaine poisoning hepatitis in the world.Acting on internal and international of the antitoxin product cocaine of Herba Fici Simplicissimae all is to find first.Except the hepar damnification of anti-cocaine, we also observe Herba Fici Simplicissimae simultaneously has certain inhibitory action to the mice exaltation effect that cocaine brings out.
Herba Fici Simplicissimae is a kind of medicine-food two-purpose plant.Though also do not verify the efficacy component chemical compound in the Radix Fici Simplicissimae extract at present; we are also carrying out correlation test nervously; but our result of study up to the present demonstrates the protective effect of Radix Fici Simplicissimae extract to body, and the prompting body is suitably taken the serviceability of exogenous Herba Fici Simplicissimae in some cases.
In addition, the Herba Fici Simplicissimae preparation method is fairly simple, and also comparing of plant growing characteristics research is thorough, the planting base of certain scale has been arranged, so the source of medical material and economy are all secure.Property is admitted than higher in the market of medicine-food two-purpose plant, the acceptance height in market, good market prospects.
The specific embodiment
The embodiment that provides below is used for further illustrating the present invention, and does not constitute limitation of the scope of the invention.
1. material
The used Herba Fici Simplicissimae decoction pieces of embodiment is provided by medical material market, Haozhou.Be accredited as Radix Fici Simplicissimae through our crude drug botany teacher professor Chen Hubiao.
Other medicine, reagent and laboratory animal can both be commercial easily.
2. preparation method example
Get Radix Fici Simplicissimae decoction pieces 1000g, pulverize, wash 3 times, add water 2500ml and decoct, totally three times, each 15 minutes, collecting decoction filtered, and it is 1.25 thick paste that filtrate is condensed into relative density, continue to be evaporated to dried, must brown ceramic powder 44g, promptly.
Application example is enumerated,
(1) get pulverizing of 1kg Radix Fici Simplicissimae extract and mistake 100 mesh sieves, enter the appropriate amount of starch mixing, the preparation granule carries out packing, every bag of 2g behind the granulate.
(2) get Radix Fici Simplicissimae extract 1000g, hydroxyethyl-cellulose 10g, tabletting is made tablet, is placed in the vessel of normal temperature drying standby.
(3) Radix Fici Simplicissimae extract is water-soluble, can directly use normal saline preparation injection on demand.
(4) Radix Fici Simplicissimae extract is water-soluble, can directly be mixed with oral liquid.
(5) Radix Fici Simplicissimae extract can cooperate with medicine such as Radix Glycyrrhizae extract and makes compound mixture and be used for the treatment of hepatitis.
3. test method
The auxiliary treatment drug effect study portion of the anti-various drug intoxication hepatitis of Radix Fici Simplicissimae extract
Laboratory animal is male ICR mouse or MT (/-) mice, and body weight is 22～26g, is provided by Department Of Medicine, Peking University's Experimental Animal Center.Duration of test provides the tap water and the normal diet of capacity, and animal housing keeps 22 ℃, automatic ventilation.The grouping of animal is pressed the body weight random packet with processing with mice.Toxic hepatitis modeling group did not give any processing in preceding 3 days, the 4th day subcutaneous injection modeling chemical compound.Radix Fici Simplicissimae extract+modeling compound component was not irritated stomach 4 days, every day 1 time No. six with various dose Chinese medicine.Behind the 4th day gastric infusion 30 minutes, subcutaneous or lumbar injection modeling compound solution.The contamination of modeling chemical compound is after 24 hours, and all animal endocanthions are got blood, and disconnected marrow is put to death; leave and take liver at once, weigh, maximum leaf is dipped in 10% the formalin fixing; carry out the observation of liver cardinal principle and leave and take liver specimens, the hepatic pathology intensity of variation is observed in HE dyeing.Utilize the 7170A automatic analyzer, adopt enzyme connection-ultraviolet continuous detecting method, measure alanine transaminase (ALT) and aspartate transaminase (AST) and lactic acid dehydrogenase (LDH) activity in the serum.The statistical analysis technique experimental data is represented with mean ± standard deviation.Use the EXCEL statistical software and experimental result is adopted methods analysts such as variance analysis, t check handle, p＜0.05 thinks that group difference has significance.
After therapeutic, in the test of administration, mice is pressed the body weight random packet.Toxic hepatitis modeling group subcutaneous injection modeling chemical compound.Radix Fici Simplicissimae extract+modeling chemical compound group is irritated stomach at injection modeling chemical compound and is given Radix Fici Simplicissimae extract 1 time after 30 minutes.Dissect animal after 24 hours.Test item is same as above.
4. result of the test:
(1) effect of the anti-acetaminophen mice of Radix Fici Simplicissimae extract toxic hepatitis can be referring to table 1.
(2) effect of the anti-carbon tetrachloride mice of Radix Fici Simplicissimae extract toxic hepatitis can be referring to table 2.
(3) effect of Radix Fici Simplicissimae extract anti-cocaine mice toxic hepatitis can be referring to table 3.
The effect (serological index) of the anti-acetaminophen toxic hepatitis of table 1 Radix Fici Simplicissimae extract (x ± S)
| Radix Fici Simplicissimae extract (g/kg) | ALT (IU/L) | AST (IU/L) | LDH (IU/L) |
| Matched group acetaminophen model group 8 16 24 | 72±53 8410±6184 # 493±898 * 52±16 * 79±45 * | 133±51 5300±6364 * 291±341 * 153±22 * 140±35 * | 394±65 16380±13088 * 1519±2190 * 401±119 * 452±133 * |
Annotate:
#Compare p＜0.05 with matched group.
*Compare p＜0.05 with model group
The effect (serological index) of the anti-carbon tetrachloride poisoning hepatitis of table 2 Radix Fici Simplicissimae extract (x ± S)
| Radix Fici Simplicissimae extract (g/kg) | ALT (IU/L) | AST (IU/L) |
| Matched group carbon tetrachloride model group 8 16 24 | 36±9 2269±1322 # 2201±1227 1845±695 1076±672 * | 131±56 801±447 # 911±535 792±415 453±243 * |
Annotate:
#Compare p＜0.05 with matched group.
*Compare p＜0.05 with model group
The effect (serological index) of administration anti-cocaine toxic hepatitis behind table 3 Radix Fici Simplicissimae extract (x ± S)
| Radix Fici Simplicissimae extract (g/kg) | ALT (IU/L) | AST (IU/L) |
| Matched group cocaine model group 8 24 | 46±6 8628±8495 # 1265±1203 1214±689 * | 138±34 1377±680 # 431±332 * 532±472 * |
Annotate:
#Compare p＜0.05 with matched group.
*Compare p＜0.05 with model group
Claims (3)
1. the application of Herba Fici Simplicissimae in the medicine of preparation cocaine poisoning hepatitis.
2. the application of Herba Fici Simplicissimae in the medicine of preparation carbon tetrachloride poisoning hepatitis.
3. the application of Herba Fici Simplicissimae in the medicine of preparation acetaminophen toxic hepatitis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510002111 CN1284553C (en) | 2005-01-14 | 2005-01-14 | Application of five-finger fig in preparing adjuvant for treating hepatitis and health foods |
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| CN 200510002111 CN1284553C (en) | 2005-01-14 | 2005-01-14 | Application of five-finger fig in preparing adjuvant for treating hepatitis and health foods |
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| CN1660354A CN1660354A (en) | 2005-08-31 |
| CN1284553C true CN1284553C (en) | 2006-11-15 |
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| CN101926852B (en) * | 2010-08-05 | 2013-05-22 | 北京大学 | Application of roots and leaves of common fig in preparing auxiliary therapy medicine and health food for hepatitis |
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