CN1056752C - Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method - Google Patents
Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method Download PDFInfo
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Abstract
The present invention relates to an anti-cancer oral liquid as a traditional Chinese medicine and a preparing method thereof. The individual component of the extract liquid of fresh giant typhonium herb root is prepared into a russet oral liquid, wherein every 1000 ml of russet oral liquid contains 500 to 3000 grams of crude medicine; after the extract liquid is matched with the medicine liquid of barbed skullcap herb, snakegourd peel, prism tuber, zedoary, etc. to be mixed, stirred and concentrated, and the mixed liquid is extracted by ethanol and is filtered; the ethanol is thoroughly extracted by heating and distillation, the mixed oral liquid is decompressed and concentrated to be in puce, and every 1000 ml of pure mixed oral liquid contains 650 to 5900 grams of crude medicine. The oral liquid has obvious tumor-suppressing effects on malignant tumors. Animal experiments proves that the tumor-suppressing rate of the oral liquid prepared from the giant typhonium herb as the individual component reaches 45.4%, and the tumor-suppressing rate of the mixed oral liquid reaches 50%. When the oral medicinal liquid is used for 39 cases of terminal cancer patients for clinic treatment, the effective rate is 51.28, and the oral liquid has no side effect.
Description
The present invention relates to a kind of Chinese medicine medicine for preventing oral liquid, this oral liquid can be equipped with Chinese medicinal ingredients such as Herba Scutellariae Barbatae, cortex trichosanthis, rhizoma sparganic, Rhizoma Curcumae simultaneously based on the Herba Typhonii gigantei Chinese medicinal ingredients.
Malignant neoplasm is one of principal disease of the healthy and life of present harm humans, present prevention and treatment for malignant tumor, be subjected to domestic and international medical circle and generally paid attention to, surgical operation therapy, radiotherapy, chemotherapy have all played certain effect to the treatment cancer.But also there are some problems equally in above-mentioned Therapeutic Method, adopts surgical operation to damage human body vigour, tumor relapse rate height easily; Especially for patient with advanced cancer because the range of scatter of cancerous cell is wide, operative treatment is powerless.Adopt radiotherapy, chemotherapy side effect quite big, the health cell is had same lethal effect.Present clinical employing cyclophosphamide (be called for short CTX, Shanghai No.12 Pharmaceutical Factory produces, and lot number is 911110) has tumor killing effect preferably to malignant tumor, and is quite big but this poison of drug is paid effect, takes for a long time to cause patient's hair to come off in a large number.
It is the important wealth of human society that China Chinese medicine is learned, and unique effect is arranged aspect the cancer capturing.Chinese medicine thinks that cancer is a kind of a kind of disease that relates to the human body whole body, and its etiology and pathogenesis belongs to chronic dietary more and do not save, disorder of emotion, and excessively impairment caused by overstrain causes human righteousness's weakness, and zang-fu disharmony, qi depression to blood stasis are experienced the cancer poison and are pented up etc. and fall ill.The well-known doctor of China Qing Dynasty Wang Qingren is pointed out in errors in Medicine Corrected: because of weakness expectorant, it is main working as tonify deficiency certainly, and expectorant can be fullyed recover from an illness; This is weak and give birth to expectorant, a little less than expectorant dedicate one's life to of a specified duration, ought remove expectorant certainly.Expectorant goes and the vigour runback.This shows that the cancer virus heresy is at every moment all consuming many more that healthy energy, healthy energy are consumed in the patient body, the evil development of poison of carninomatosis fast more.The diffusion in the carcinoma later stage of clinical findings, transfer have just illustrated this point.The evil treatment naturally with healthy energy of carcinoma poison can (immunologic function etc.) be a pair of contradiction, blood not the stasis of blood then poison do not tie, the original stasis of blood of carcinoma is stagnant to be held poison and causes, heresy is not except that then just again.Therefore, the treatment cancer should strengthening vital QI to eliminate pathogenic factors, blood circulation promoting and blood stasis dispelling, enhancing human body immunity ability, the anticancer growth and the cell that protects the health.The Chinese herbal medicine that has above-mentioned effect in the traditional Chinese medical science materia medica has a lot, for example Herba Scutellariae Barbatae, Herba Patriniae, Herba Hedyotidis Diffusae, Rhizoma Paridis, rhizoma sparganic, Flos Carthami, Radix Astragali or the like, and said medicine selects suitable component proportioning that certain prevention and treatment cancer effect are all arranged.Two kinds of anticarcinogens that Chinese invention patent CN93100223.0 and CN93110424.3 introduce belong to wherein two examples, and above-mentioned two kinds of cancer therapy drug common features are to need two or more Chinese medicines to work in coordination with to play a role, and its certain tcm components is used for the treatment of the cancer poor effect separately.
Herba Typhonii gigantei rhizome section airing, the traditional Chinese medical science is referred to as Rhizoma Typhonii.According to putting down in writing in the Chinese medicine: the Rhizoma Typhonii drug main will be used for the treatment of skin ulcer, malignant tumor.Be used for the treatment of cancer for the bright juice of Herba Typhonii gigantei rhizome and do not meet relevant report as yet.
In order to excavate Herba Typhonii gigantei rhizome new medicine use, the effect unique of performance Herba Typhonii gigantei aspect the treatment cancer, the purpose of this invention is to provide that a kind of to contain the bright juice extracting solution of Herba Typhonii gigantei rhizome be main, be equipped with component water extract pharmaceutical compositions such as Herba Scutellariae Barbatae, cortex trichosanthis, rhizoma sparganic, Rhizoma Curcumae, the Radix Astragali, make anticancer series oral liquid.
Bright Herba Typhonii gigantei rhizome has acrid-sweet flavor dampness, returns taste to return, and drying dampness to eliminate phlegm is expellingged wind and relieving convulsion, the effect of detoxicating and resolving stagnation of pathogens, adopts the bright juice of Herba Typhonii gigantei of single component that malignant tumor is had tangible tumor killing effect.This point is tested by animal and clinical observation confirms.With 50% ethanol extract of bright Herba Typhonii gigantei rhizome one-component, when containing Herba Typhonii gigantei rhizome medicine among the every 1000ml of the oral liquid of making and being equivalent to 500 grams～3000 gram crude drug amounts, different times and various cancer all there is certain tumor killing effect.To clean the bright Herba Typhonii gigantei rhizome of peeling among the present invention rubs, the back an amount of concentration of adding of weighing is 50% ethanol, with filtration or centrifugalize mode the rhizome slag is leached after soaking certain hour, soak the rhizome slag so that take out Herba Typhonii gigantei rhizome pharmaceutical compositions as far as possible with the ethanol secondary, extracted twice liquid is fully mixed, distillation concentrates and carries except that ethanol, add an amount of distilled water and adjust the oral medicine liquid component content, the bright juice of Herba Typhonii gigantei rhizome that makes it to contain in every 1000ml oral liquid is equivalent to 500 grams～3000 gram crude drug amounts.The Herba Typhonii gigantei oral liquid of single component is yellowish-brown.
According to traditional Chinese medical science medicine scientific principle opinion, above-mentioned Herba Typhonii gigantei oral liquid can be used as monarch drug, be equipped with water such as Herba Scutellariae Barbatae, cortex trichosanthis, rhizoma sparganic, Rhizoma Curcumae, Flos Lonicerae, Radix Sophorae Flavescentis simultaneously and carry medicinal liquid as ministerial drug, the aqueous extract component of ministerial drug can be selected for use wherein a kind of, perhaps select wherein two or more aqueous extract component for use, make the mixing oral liquid, be used to improve above-mentioned Herba Typhonii gigantei oral liquid tumor killing effect.When selecting for use Herba Scutellariae Barbatae to be ministerial drug, the component content of every 1000ml mixing oral liquid Herba Scutellariae Barbatae is equivalent to 150 grams～300 gram crude drug amounts.It is hot little bitter cool that this mixes oral liquid, returns liver, lung, stomach through, heat-clearing and toxic substances removing, diuresis of blood circulation promoting, and it is better to be used for gastric cancer, pulmonary carcinoma, liver cancer efficacy.
Equally, also can contain Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Solani Lyrati or Herba Duchesneae Indicae in the above-mentioned Herba Typhonii gigantei oral liquid, wherein a kind of or two or more aqueous extract component wherein, each aqueous extract component content sum, every 1000ml is equivalent to 150 grams～400 gram principal agent amounts.When selecting two or more aqueous extract component for use, the consumption proportion of various aqueous extract components is optional, but its amount ranges still need remain within the above-mentioned given crude drug amount.
The Radix Astragali has tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening, the swollen effect of diuretic, as above-mentioned oral adjuvant drug, has the adjusting body immunity with the Radix Astragali, strengthens the effect of resistance against diseases.The every 1000ml of this oral liquid contains Radix Astragali aqueous extract component and is equivalent to 100 grams～350 gram crude drug amounts.
Rhizoma Curcumae, rhizoma sparganic have the liver of returning spleen channel, removing blood stasis, the promoting the circulation of QI to relieve pain effect, and Rhizoma Curcumae has direct killing effect to cancer cell such as cervical cancer, carcinoma vulvae and skin carcinomas; Rhizoma sparganic has inhibitory action to cancerous cell, and it is better that both are used effect.In the oral liquid that contains Rhizoma Curcumae and rhizoma sparganic aqueous extract component and above-mentioned other component thereof provided by the invention, the crude drug amount of Rhizoma Curcumae is 75 grams～300 grams among every 1000ml; The crude drug amount of rhizoma sparganic is 50 grams～150 grams.Rhizoma Curcumae, rhizoma sparganic can be used as ministerial drug and use.
Flos Lonicerae, Radix Sophorae Flavescentis, Semen Persicae have broad-spectrum antiseptic, wind dispelling insecticide, blood stasis dispelling respectively and moisten just effect, are used in the above-mentioned various oral liquid as ministerial drug, therapeutic effect that can corresponding raising oral liquid.Among the present invention, can select for use wherein a kind ofly, perhaps select for use wherein two kinds, three kinds aqueous extract components to add in the above-mentioned various oral liquid, its every 1000ml of crude drug consumption separately contains 50 grams～250 grams.Replace Flos Lonicerae, Radix Sophorae Flavescentis, Semen Persicae aqueous extract component with Herba Taraxaci, Spica Prunellae, Radix Berberidis aqueous extract component, also can reach similar therapeutic effect.Above-mentioned three kinds of alternative medicine can be selected for use wherein a kind of, perhaps two kinds, three kinds aqueous extract components.Every 1000ml crude drug content separately is 50 grams～250 grams.
Among the present invention, adjuvant drug also can be selected the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis or Radix Pseudostellariae aqueous extract component for use, adds in the above-mentioned oral liquid, wherein is equivalent to 100～250 grams among the every 1000ml of the amount of crude drug separately of the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis, and Radix Pseudostellariae crude drug amount is equivalent to 100 grams～300 grams.
Select for use Radix Glycyrrhizae as messenger drug among the present invention,, strengthen the liver detoxification ability to coordinate, to relax all medicine components property of medicine.All can add liquorice beverage extracting solution component in the above-mentioned hybrid medicine oral liquid, its component content is equivalent to 50～150 gram crude drug amounts among every 1000ml.
Preparation method provided by the present invention comprises that with the bright juice of ethanol extraction Herba Typhonii gigantei rhizome make the Herba Typhonii gigantei rhizome active drug composition overwhelming majority be dissolved in ethanol, centrifugal filtration then goes out medicinal residues, makes to contain the bright juice of alcoholic acid Herba Typhonii gigantei rhizome.After its preparation method is independently finished, carry the medicinal liquid mix homogeneously with other component medicine water of the present invention again, add thermal distillation defecation ethanol, suitably adjust the various medicament contgs of oral liquid with distilled water behind the concentrating under reduced pressure, make among every 1000ml, various drug component component contents reach within 600～5900 gram crude drug dose amount ranges.The bright juice of ethanol extraction Herba Typhonii gigantei rhizome is carried other component medicine medicinal liquid with water and is mixed mutually that to produce oral liquid of the present invention be the inventive method main feature.
In the said method, various component drug extracts can adopt extracted twice, and the medicinal liquid mixing of extracted twice is got final product.Should be stirred frequently with the bright juice of ethanol extraction Herba Typhonii gigantei rhizome, soak time is 24 hours at every turn.Above-mentioned mixed liquor heating adds 95% ethanol that is three times in the mixing liquid measure after concentrating and being placed to room temperature again, leaves standstill 48 hours, and is rotten to prevent the leaving standstill process oral liquid, filters out the precipitation medicinal residues with silk at last, adds thermal distillation defecation ethanol.And transfer to requirement with distilled water.In above-mentioned oral liquid, add 0.20% sorbic acid or add 0.05% nipalgin and reach antiseptic effect.Above-mentioned oral liquid is encapsulated in 10ml or the 20ml bottle, with 100 ℃ of moving air sterilizations 30 minutes, qualified can the dispatching from the factory of bacterium inspection.The pH value of medicinal liquid is 4.5.
The present invention holds up with medicine, heat-clearing and toxic substances removing, promoting blood circulation and breaking stagnations such as Herba Scutellariae Barbatae, cortex trichosanthis, rhizoma sparganic, Rhizoma Curcumae based on the bright juice of Herba Typhonii gigantei rhizome, and promoting the circulation of QI to relieve pain add medicines such as the Radix Astragali, normal ginseng, the Rhizoma Atractylodis Macrocephalae again and assist the monarch drug strengthening vital QI to eliminate pathogenic factors, improve body resistance against diseases.The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, the detoxifcation relieving spasm to stop pain is coordinated all medicines.Oral liquid provided by the present invention all has tangible tumor killing effect.Prove that through the mice animal experiment the every 1000ml of single component is equivalent to the bright juice oral liquid of Herba Typhonii gigantei rhizome of 1375 gram crude drug amounts, it presses down the tumor average effect can reach 45.4%; By the oral liquid that 12 flavor Chinese medicines such as Herba Typhonii gigantei, Rhizoma Curcumae, the Radix Astragali, Radix Codonopsis are made, the oral liquid tumor killing effect that every 1000ml is equivalent to 3725 gram crude drug amounts is 38.9%～50%, and the present invention is as follows to the tumor-inhibiting action result of study of mice transplanted tumor S180:
One, medicine: this antitumor oral liquid system is made up of 12 flavor Chinese medicines such as Herba Typhonii gigantei, Rhizoma Curcumae, the Radix Astragali, Radix Codonopsis.Be every milliliter of dark brown liquid that is equivalent to 3.725 gram crude drugs.
Herba Typhonii gigantei extracting solution (for one of main Chinese medicine in the antitumor oral liquid of the present invention) is every milliliter of yellowish-brown liquid that is equivalent to 1.375 gram crude drugs.Cyclophosphamide (hereinafter to be referred as CTX) is produced for Shanghai No.12 Pharmaceutical Factory.Lot number: 911110.
Two, animal: be the Kunming mouse of institute for drug control, port, Dalian animal center breeding.Body weight 17～22 grams, male and female half and half.
Three, struma: employed murine sarcoma 180 (S180) is to come to institute of Materia Medica,Chinese Academy of Medical Sciences.
Four, method: tumor inoculation method, efficacy evaluation, all test by " the screening rules in the antineoplastic agent object " of national cancer therapy drug cooperative association justice in 1978 formulation.
Select the Kunming mouse of body weight 17～22 grams for use, random packet, 0.2 milliliter of back subcutaneous injection S180 oncocyte thin liquid (ascitic type, 1: 3 or dilution in 1: 2).After 24 hours, experimental group is by milliliter/kilogram, and this gallbladder antitumor oral liquid of lumbar injection is 10,5,2.5 or 15,7.5,4 milliliters respectively.Positive controls, lumbar injection CTX20 milligram/kilogram.Negative control group, intraperitoneal injection of saline.Behind the successive administration 10 days, put to death animal, get tumor and weigh.
The Herba Typhonii gigantei experimental group, 25 milliliters/kilogram of every Mus lumbar injection Herba Typhonii gigantei extracting solution.Experimental result sees Table:
Table 1 antitumor oral liquid of the present invention to heavy (g) tumour inhibiting rate P value (ml/Kg) X ± SD at the whole story at the whole story (%) 10 14 14 21.6 30.3 1.1 ± 0.7 38.9＜0.05 5 10 10 21.2 28.9 1.73 ± 0.99 31.7 2.5 10 10 21.4 29.7 1.4 ± 0.56 22.2 salt solution 88 21.7 27.6 1.8 ± 0.54 of the average knurl of tumor killing effect () the group N average weight (g) of mouse S180-
Table 2 antitumor oral liquid of the present invention is to the tumor killing effect of mouse S180, (2) group N average weight, (g) average knurl is heavy, (g) tumour inhibiting rate P value, (ml/Kg) whole story at the whole story X ± SD, (%) 10 11 11 17.9 21.6 1.2 ± 0.9 50＜0.01 5 10 10 17.6 22.5 1.7 ± 1.2 29 2.5 10 10 17.7 21.4 2.8 ± 2.0-17 CTX 10 10 17.5 24.7 0.36 ± 0.4 85 salt solution 14 14 17.6 21.7 2.4 ± 1.0-
Table 3 antitumor oral liquid of the present invention is to the tumor killing effect of mouse S180, (3) group N average weight, (g) average knurl is heavy, (g) tumour inhibiting rate P value, (ml/Kg) whole story at the whole story X ± SD, (%) 15 11 10 19.0 24.0 1.36 ± 0.74 40＜0.05 7.5 11 9 18.8 24.3 1.62 ± 1.0 28.6 4 10 10 18.8 24.9 1.61 ± 0.92 29CTX 10 10 18.8 24.3 0.30 ± 0.32 86.8 salt solution 10 9 19.0 24.2 2.27 ± 1.0-
Five, result:
In above-mentioned three experiments, the tumour inhibiting rate of high dose group is all more than 30%, wherein the inhibitory rate to 50% of second batch of experiment.Learn processing through system juice, significant difference, the P value is all＜0.05.The experimental group of tumour inhibiting rate 50%, P value＜0.01, difference highly significant.
When the mice body weight after testing front and back and testing was compared, when not seeing increased dosage amount, body weight gain was stagnated, even descend, illustrates that this poison of drug is little.
Table 4 Typhonium giganteum extract to the tumor killing effect of mouse S180, heavy (g) tumour inhibiting rate P value (ml/Kg) X ± SD at the whole story at the whole story (%) 25 10 10 19.0 25.5 1.24 ± 0.9 45.4＜0.05 salt solution 10 9 19.0 24.2 2.47 ± .0 of the average knurl of group X average weight (g)-
Experimental result shows, the Herba Typhonii gigantei extracting solution is at 25 milliliters/kilogram, inhibitory rate to 45.4%, P value＜0.05, significant difference.
Illustrate that Herba Typhonii gigantei brought into play tumor-inhibiting action in antitumor oral liquid of the present invention.
The present invention selects Herba Typhonii gigantei rhizome 1925 grams, Rhizoma Curcumae 125 grams, rhizoma sparganic 50 grams, Herba Scutellariae Barbatae 300 grams, Radix Codonopsis 160 grams, Radix Sophorae Flavescentis 150 grams, the Radix Astragali 250 grams, the Rhizoma Atractylodis Macrocephalae 200 grams, Semen Persicae 100 grams, cortex trichosanthis 240 grams, Flos Lonicerae 150 grams, Radix Glycyrrhizae 75 gram crude drug amounts for use, makes every 1000ml and contains the dark brown oral liquid that said medicine extracting solution component crude drug amount total amount is 3725 grams.This oral liquid is used to face end treatment patient with advanced cancer 39 examples, and effective percentage is 51,28%.Above-mentioned oral liquid clothes dosage is each 20ml, and every day three times, ante cibum is oral.Be 30 days～60 days the course of treatment.
This medicine decapacitation suppresses to improve patient's immunity function in addition outside the tumor growth.In cell of being done and humoral immunization index, treat the back and treat preceding contrast as seen, E-RFC difference highly significant (P＜0.01); LTT and IgM significant difference (P＜0.05), all the other every immune indexes all have raising in various degree.Subjective symptoms such as malaise, inappetence, dysphagia before and after the patient takes medicine, feel sick, vomiting, abdominal distention, stomachache, cough, expectoration, chest pain etc. all have improvement in various degree, alleviated patient's misery, correspondingly improve patient's quality of life, prolonged patient's life span.
This medicine does not have obvious toxic and side effects, and except that minority case (8%) clothes back stomach has the slight burn feeling, but spontaneous remission does not need special handling.Treat the back and treat preceding inspection from liver, renal function, have no adverse effects recently.Erythrocyte, leukocyte, platelet before treating the back and treating detect contrast zero difference (P＞0.05).Illustrate that this medicine is to bone marrow unrestraint effect.
Taking a broad view of this medical instrument has certain curative effect, can suppress the growth of malignant tumor, and the effect that improves patient's immunologic function is arranged.And not having obvious toxic and side effects, is that a kind of late malignant tumour for the treatment of is worth continuing the medicine that research and extension is used.
Introduce the several embodiment of the present invention below.
Embodiment one: select Herba Typhonii gigantei rhizome 2000 grams, Herba Scutellariae Barbatae 200 grams or Herba Lobeliae Chinensis 200 grams for use, make every 1000ml and contain the oral liquid that said extracted liquid component is 2200 gram crude drug amounts, preparation method as mentioned above.
Embodiment one: select Herba Typhonii gigantei rhizome 1500 gram, Herba Lobeliae Chinensis 100 grams, Herba Hedyotidis Diffusae 150 grams, Herba Solani Lyrati 80 grams, Herba Duchesneae Indicae 50 grams for use, making every 1000ml, to contain said extracted liquid component be that oral liquid, the preparation method of 1880 gram crude drug amounts is identical.
Embodiment three: select for use Herba Typhonii gigantei rhizome 1250 grams, Herba Scutellariae Barbatae 150 grams, cortex trichosanthis 150 to restrain, make every 1000ml and contain the oral liquid that above-mentioned three kinds of extracting solution components are 1550 gram crude drug amounts, adding the Radix Astragali 230 gram crude drug amounts in the perhaps above-mentioned again component, making every 1000ml and contain the oral liquid that the extracting solution component is 1780 gram crude drug amounts.
Embodiment four: the crude drug water gaging extracting solution component that adds Rhizoma Curcumae 170 grams and rhizoma sparganic 120 grams in the present embodiment one, two, three.
Embodiment five: add Flos Lonicerae 50 grams, Radix Sophorae Flavescentis 100 grams, Semen Persicae 80 gram crude drug water gaging extracting solution components in the foregoing description four, make corresponding increase by 230 grams of crude drug amount in every 1000ml oral liquid.
Embodiment six: add Herba Taraxaci 80 grams, Spica Prunellae 120 grams, Radix Berberidis 210 gram crude drug water gaging extracting solution components in the foregoing description four, make corresponding increase by 410 grams of every 1000ml oral liquid crude drug amount.
Embodiment seven: in embodiment five, adds the Rhizoma Atractylodis Macrocephalae 100 grams, Radix Codonopsis 150 gram crude drug water gaging extracting solution components, makes corresponding increase by 250 grams of every 1000ml oral liquid crude drug amount, or corresponding adding Radix Pseudostellariae 250 gram crude drug water gaging extracting solution components.
Embodiment eight: Radix Glycyrrhizae 100 gram crude drug water gaging extracting solution components are added in the oral liquid that embodiment seven make, make corresponding increase by 100 grams of every 1000ml oral liquid crude drug amount.
Claims (10)
1. Chinese medicine antitumor oral liquid contains 50% ethanol extract of bright Herba Typhonii gigantei rhizome one-component in essence, and the Herba Typhonii gigantei rhizome pharmaceutical compositions that every 1000ml oral liquid contains in this extracting solution is equivalent to its 500 gram～3000 gram crude drug amounts.
2. antitumor oral liquid according to claim 1 is characterized in that containing in the said oral liquid Herba Scutellariae Barbatae aqueous extract component, and its component content is equivalent to 150 grams～300 gram crude drug amounts in every 1000ml oral liquid.
3. antitumor oral liquid according to claim 1, it is characterized in that containing in the said oral liquid wherein a kind of aqueous extract component of Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Solani Lyrati or Herba Duchesneae Indicae, perhaps contain wherein two or more aqueous extract component, each aqueous extract component content is equivalent to 150 grams～400 gram crude drug amounts in every 1000ml oral liquid, adopt two or more aqueous extract component, the each component consumption proportion is optional, and its consumption sum is within above-mentioned given crude drug weight range.
4. according to claim 1,2 or 3 described antitumor oral liquids, it is characterized in that containing in the said oral liquid cortex trichosanthis aqueous extract component, its component content is equivalent to 100 grams～300 gram crude drug amounts in every 1000ml oral liquid.
5. antitumor oral liquid according to claim 4 is characterized in that containing Radix Astragali aqueous extract component in the said mouthful of liquid draw, and its component content is equivalent to 100 grams～350 gram crude drug amounts in every 1000ml oral liquid.
6. according to claim 1,2,3 or 5 described antitumor oral liquids, it is characterized in that containing in the said oral liquid Rhizoma Curcumae and two kinds of aqueous extract components of rhizoma sparganic, the component content of Rhizoma Curcumae and rhizoma sparganic is equivalent to 75 grams～300 grams and 500 grams～150 gram crude drug amounts respectively in every 1000ml oral liquid.
7. antitumor oral liquid according to claim 6, it is characterized in that containing in the said oral liquid wherein a kind of aqueous extract component of Flos Lonicerae, Radix Sophorae Flavescentis, Semen Persicae, perhaps two kinds, three kinds aqueous extract components wherein, the component content separately of Flos Lonicerae, Radix Sophorae Flavescentis, Semen Persicae is equivalent to 50 grams～250 gram crude drug amounts in every 1000ml oral liquid.
8. antitumor oral liquid according to claim 5, it is characterized in that containing in the said oral liquid Herba Taraxaci, Spica Prunellae, Radix Berberidis wherein one or both, three kinds of aqueous extract components, Herba Taraxaci in every 1000ml oral liquid, multiple hay, Radix Berberidis component content separately are equivalent to 50 grams～250 gram crude drug amounts.
9. according to claim 1,2,3,5,7 or 8 described antitumor oral liquids, it is characterized in that containing in the said oral liquid Rhizoma Atractylodis Macrocephalae and Radix Codonopsis or Radix Pseudostellariae aqueous extract component, in every 1000ml oral liquid the Rhizoma Atractylodis Macrocephalae and Radix Codonopsis composition separately content be equivalent to 100 grams～250 gram crude drug amounts, the Radix Pseudostellariae component content is equivalent to 100 grams～300 gram crude drug amounts.
10. antitumor oral liquid according to claim 9 is characterized in that containing in the said oral liquid liquorice beverage extracting solution component, and the Radix Glycyrrhizae component content is equivalent to 50 grams～150 gram crude drug amounts in every 1000ml oral liquid.
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| CN102726462B (en) * | 2012-06-22 | 2013-11-27 | 杨凌农科大无公害农药研究服务中心 | Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method |
| CN104800779A (en) * | 2015-05-25 | 2015-07-29 | 郭峰 | Traditional Chinese medicine preparation for relieving ovary choriocarcinoma and preparation method thereof |
| CN106578199A (en) * | 2016-12-16 | 2017-04-26 | 横琴智库转化医学有限公司 | Oral solution for preventing malignant tumors |
| CN110507784A (en) * | 2019-08-01 | 2019-11-29 | 浙江尤克里里制药技术有限公司 | A kind of carcinoid Chinese medicine detumescence spray and preparation method thereof |
| CN113456785A (en) * | 2021-08-20 | 2021-10-01 | 饶本强 | Traditional Chinese medicine composition for promoting blood circulation and removing blood stasis for anti-tumor metabolic therapy, and preparation method and application thereof |
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| 《肿瘤疾病千首妙方》第一版 1991.10.1 樊中州，中国人口出版社;《中药材》15(1) 1992.1.1 王铁僧，"江浙地区民间及临床常用抗癌中草药的原植物整理的应用介绍";《中医药学报》2(1) 1987.1.1 杨维益"八十年代中医药治疗肿瘤的进展";《中成药研究》1983(10) 1983.1.1 贾文成等，"中药药理研究的一些进展" * |
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