CN104800779A - Traditional Chinese medicine preparation for relieving ovary choriocarcinoma and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for relieving ovary choriocarcinoma. The traditional Chinese medicine preparation is prepared from codonopsis pilosula, fried atractylodes macrocephala, schisandra chinensis, asparagus cochinchinensis, ophiopogon japonicus, coix seeds stir-fried with bran, patrinia scabiosaefolia, solanum lyratum, radix actinidiae chinensis, duchesnea indica, curcuma longa, sophora flavescens, boswellia carteri, myrrh, akebia trifoliata, nidus vespae, verbena officinalis, corydalis yanhusuo, sargentodoxa cuneata, melia toosendan, hedyotis diffusa, vinegared spaganium stoloniferum, vinegared rhizoma zedoariae and raw glycyrrhiza uralensis according to a certain weight ratio. The traditional Chinese medicine preparation has the effects of tonifying the kidney and calming the mind, nourishing Yin to moisten dryness, clearing away heat and toxic materials and eliminating carbuncle and evacuating pus and can be used for inhibiting cancer cell spreading and enhancing the constitution of patients, thereby playing a role in controlling and relieving the ovary choriocarcinoma.

Description

A kind ofly alleviate Chinese medicine preparation of ovary choriocarcinoma and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation alleviating ovary choriocarcinoma, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Choriocarcinoma is a kind of tumor of high malignancy, after being secondary to hydatidiform mole, miscarriage or term labor.Its incidence is approximately 0.0001% ~ 0.36%, and minority mostly is Women in menopause after can betiding ectopic pregnancy.The ovary betiding unmarried woman is once in a while called constitutional choriocarcinoma.In the fifties, mortality rate is very high.After in choriocarcinoma, gestational choriocarcinoma is secondary to abnormal gestation substantially; Non-gestational choriocarcinoma (also claiming constitutional choriocarcinoma), other malignant tumor of reason and health of generation are the same, cancerated by self normal somatic cell, are a kind of rare tumors of human body.Ovary choriocarcinoma has been mainly for: 1, cause ectopic pregnancy.The disease stimulation of choriocarcinoma can cause fallopian tube edema, mucosa is thinning, is unfavorable for the combination of sperm and ovum, and treats not in time, aggravation, because the necrosis of mucosal epithelial cells, adhesion can be there is, blocking in fallopian tube, affect passing through of sperm, even if with ovum combines and can not arrive uterus in time, ectopic pregnancy may be caused, threaten the health of women.2, ovary normal function is damaged.The real catastrophic effect of choriocarcinoma is the physiological function that ovary cannot be brought into normal play.But ovary not only carries and produces ovum and be skillful in combining, create continuity human history important task, but also carry the distinctive estrogen of women, the secretion of progestogen and androgen, support the secondary sex characteristics of women; Breast is highly full of, tall and straight, uterus is dynamic: make the tender exquisiteness of skin hundred, lines are soft and moist winsome.Choriocarcinoma not only can make female infertility, and secondary sex characteristics weakens and disappears, and still directly can cause endocrine disturbance, cause skin senilism, steal the beauty of woman.

Women's health in the serious threat of ovary choriocarcinoma, but the current treatment for this disease is based on chemotherapy, operation is auxiliary, these means medical expenses are high, can cause larger injury to the health of patient, and operative treatment is by organs resection, causes and loses fertility all the life, even make women lose secondary sex characteristics, bring irreversible damage to women.

China's traditional Chinese medical science thinks that ovary choriocarcinoma is because women's exhaustion due to sexual indulgence fecund, the positive QI-insufficiency of ferritic, therefore when embry ogenesis, existing exopathogen invasion is won mutually with essence and blood, and the stagnant vessels of the uterus of the stasis of blood lies prostrate appoints in punching.After childbirth or miscarriage, vessels of the uterus is hollow, blood deficiency and blood stasis, and blood stasis stagnates, and mechanism of qi is hindered Jian Cheng Han abdominal mass.Venation block is obstructed, and blood fortune is not normal, and blood stasis does not go, and fresh blood difficulty peace, strongly fragrant heat-transformation of a specified duration, accumulates in evil poison, and cloudy Tianjin of burning, causes deficiency of vital QI, and General Symptoms, appears in function exhaustion.Therefore Chinese medicine is good at carrying out dialectical treating from the angle of entirety, by the growth of inhibition tumor cell, improves patient's body constitution, increases patient's resistance, and then reaches the object of disease therapy.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation alleviating ovary choriocarcinoma, this Chinese medicine preparation has anticancer diffusion for ovary choriocarcinoma, strengthens patient body constitution, cheap, has no side effect, does not perform the operation, no pain feature.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this alleviation ovary choriocarcinoma.

Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula alleviating the Chinese medicine preparation of ovary choriocarcinoma repeatedly, the present invention selects Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Fructus Schisandrae Chinensis, Radix Asparagi, Radix Ophiopogonis, Semen Coicis (parched with bran), Herba Patriniae, Herba Solani Lyrati, Radix Actinidiae Chinensis, Herba Duchesneae Indicae, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis, Olibanum, Myrrha, Fructus Akebiae, Nidus Vespae, Herba Verbenae, Rhizoma Corydalis, Caulis Sargentodoxae, Fructus Toosendan, Herba Hedyotidis Diffusae, stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is kidney calming, nourishing YIN to relieve dryness, heat-clearing and toxic substances removing, effect of eliminating carbuncle evacuation of pus, thus can effectively control to alleviate and treat ovary choriocarcinoma.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduce blood viscosity and plasma viscosity, and have blood pressure lowering, blood fat reducing, antioxidation, defying age, improves the immunity of human body.

Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.The Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.The Rhizoma Atractylodis Macrocephalae also has the function promoting hemopoietic.

Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Radix Asparagi: be the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor: sweet, bitter, cold.Return lung, kidney channel.Effect: nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.Radix Asparagi and Radix Ophiopogonis often use simultaneously, to strengthen nourishing lung-YIN, the effect of the relieving restlessness that clears away heart-fire.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.

Semen Coicis (parched with bran): Semen Coicis is the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Parched with bran is for frying to micro-yellow according to parched with bran method.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.This product has again a merit of spleen invigorating, and in order to control edema due to deficiency of the spleen, beriberi swells and ache, and this product can eliminating dampness by diuresis, again can relaxing muscles and tendons arteries and veins, and slow contraction is anxious, is good at the damp dispelling muscle muscles and bones, therefore is used for arthralgia chiefly caused by damp pathogen, because it is cool in nature, therefore be more suitable for for damp and hot arthralgia pain.

Herba Patriniae: be Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch. ex Link., patrima villosa (bitter vegetarian) P. villosa (Thunb.) Juss., with root stock and root, all herbal medicine.Nature and flavor: pungent, bitter, cool.Return stomach, large intestine, Liver Channel.Effect: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.The compatibility such as normal and Caulis Sargentodoxae, Semen Coicis, Semen Persicae, Cortex Moutan, Radix Et Rhizoma Rhei clinically, with controlling acute appendicitis; With compatibilities such as Herba Houttuyniae, Radix Platycodonis, Semen Coicis, Semen Benincasae, Rhizoma Phragmitiss, with controlling lung abscess (lung abscess); With the compatibility such as Flos Lonicerae, Fructus Forsythiae, with controlling sore and toxic, mash external application with the fresh grass of this product simultaneously.Join the medicine such as Flos Carthami, Fructus Crataegi, control postnatal blood stasis, the disease such as twinge in abdomen.Join Herba Taraxaci, Flos Lonicerae, with controlling acute conjunctivitis, conjunctival congestion is swollen and ache; Join Herba Artemisiae Scopariae, Fructus Gardeniae etc. and control acute icterohepatitisshock.

Herba Solani Lyrati: be Solanaceae activity of Solanum Lyratum Thunb Solanum lyratum Thunb. [S. dulcamara L. var. lyratum (Thunb.) Sieb. et Zucc., S. Dulcamara L. var. pubescens Blume, S.Dulcamara L. var. chinense Dunal], be used as medicine with herb or root.Nature and flavor: bitter are flat; Slightly poisonous.Enter liver, stomach warp.Effect: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anticancer.

Radix Actinidiae Chinensis: be the root of Fructus actinidiae chinensis section plant Fructus actinidiae chinensis.Nature and flavor: sour, puckery, cool.Effect: heat-clearing and toxic substances removing, expelling wind and removing dampness, diuresis is stopped blooding.For rheumatic ostalgia, and the disease such as jaundice.Be used in various cancer, the cancer applications especially for intestines and stomach aspect is more.

Herba Duchesneae Indicae: Rosaceae Herba Duchesneae Indicae platymiscium Herba Duchesneae Indicae Duchesnea indica (Andr.) Focke, with all herbal medicine.Nature and flavor: sweet, sour, cold.Slightly poisonous.Effect: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For cold, fever, cough, infantile hyperpyrexia infantile convulsion, laryngopharynx swelling and pain, diphtheria, icterohepatitis, bacillary dysentery, amebic dysentery, menorrhagia; Parotitis is controlled in external, venom, eye conjunctivitis, furuncle swelling toxin, herpes zoster, eczema.Also curing cancers can be tried.And can be used for killing wriggler, fly larvae.Going through tuberculosis for carbuncle furunculosis, scrofula, the medicines such as Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici, Spica Prunellae can being joined with using; For cancerous protuberance.

Rhizoma Curcumae Longae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L..Nature and flavor: pungent, bitter, temperature.Return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.Rhizoma Curcumae Longae and Radix Curcumae control arm backache with the use of kind.

Radix Sophorae Flavescentis: be the root of pulse family perennial fallen leaves semishrub plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor: bitter, cold in nature.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Effect: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.Compendium of Material Medica is recorded: the bitter cold of Radix Sophorae Flavescentis, Cortex Phellodendri, all can the kidney invigorating, and lid gets its bitter dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again.Again by " Records of the Historian " cloud, the sick dental caries of granary public Chunyu Yi doctor doctor Qi, moxibustion left hand yangming meridian, gargles three liters with kuh-seng soup day, careful wind of coming in and going out, and more this also got the justice that it removes the damp and hot parasite killing of pathogenic wind on five, six.

Olibanum: the resin oozed out for Burseraceae Boswellia carterii platymiscium Boswellia carterii Boswellia carterii Birdw. [B. sacra Fluek.], medicine glue XIANGSHU B. bhawdajiana Birdw. and congener skin zone thereof.Nature and flavor: acrid, bitter, warm.GUIXIN, liver, spleen channel.Effect: promoting blood circulation and stopping pain, detumescence and promoting granulation.This product does not close up after being used for skin infection for a long time, and Chang Yuyu Myrrha compatibility, spreads on affected part outward.

Myrrha: the oleo-gum-resin of oozing out for Burseraceae bdellium plant myrrh Commiphora myrrha Engl. [C. molmol Engl.] and the trunk skin zone that belongs to his kind of plant together.Nature and flavor: bitter, flat.Enter Liver Channel.Effect: loose blood blood stasis removing, subduing swelling and relieving pain.Can be used for clinically treating acute mastitis.

Fructus Akebiae: be the mature fruit of plants of Lardizabalaceae Caulis Akebiae Akebia quinata (Thunb.) Decne, threeleaf akebia A.trifoliata (Thunb.) Koidz.var.australis (Dies) .Rehd..Nature and flavor: micro-hardship, property is put down.Return liver, stomach, urinary bladder channel.Effect: dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.Clinical being used for treats tuberculosis, calculus and tumor etc.

Nidus Vespae: be Vespidae insecticide hornet or the nest belonging to nearly edge insecticide together.Nature and flavor: sweet are flat, poisonous.Gui Jing: liver; Stomach; Kidney channel.Effect: wind-expelling pain-stopping; The detumescence of rose poison; Killing parasites for relieving itching.Main air temperature arthralgia pain; Wind carious pain; Carbuncle malignant boil; Scrofula; Mouthpiece swells and ache; Anal fistula; Rubella pruritus; Skin stubborn dermatitis." detailed outline ": Nidus Vespae, positive bright medicine also.The person of surgery gear division and his sick use, also all gets its treating the poisonous disease with poisonous drugs, the merit ear of parasite killing of holding concurrently.

Herba Verbenae: be the dry aerial parts of Verbenaceae Herba Verbenae Verbena officinalis L..Nature and flavor: bitter, cool.Return liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria." Bencao Jingshu ": Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom skin ulcer person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear.

Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: acrid, bitter, warm.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The pungent loose temperature of this product is led to, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, blood-activating and qi-promoting pain relieving, and the kind multiple pain controlled caused by stagnation of QI and blood, its analgesic effect is excellent.Record in " book on Chinese herbal medicine is looked for the truth ": Rhizoma Corydalis, no matter being blood is gas, amass and loose person, taking this power can be sensible, warm in nature with it, then can manage it in QI and blood can be smooth, and acrid in the mouth then can moisten can fall apart in QI and blood, so manage upper and lower all pains all over the body, merit of often walking alone is many.

Caulis Sargentodoxae: be the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae Sargentodoxa cuneata (Oliv.) Rehd. et wils..Nature and flavor: bitter, flat.Return liver, large intestine channel.Effect: relieve internal heat eliminating carbuncle, promoting blood circulation to remove obstruction in the collateral, wind dispelling insecticide, bacteriostasis.Caulis Sargentodoxae hardship is flat, is longer than heat-clearing and toxic substances removing, eliminating carbuncle pain relieving, persons particularly liable to develop skin infection's key medicine.For controlling acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.Heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind.Pain is flutterred for abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, traumatic injury.Clinically to acute and chronic appendicitis, abscess of appendix has good therapeutic effect.

Fructus Toosendan: be the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb. et Zucc..Nature and flavor: bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Effect: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Nature and flavor: sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.Comparatively high inhibition effect is had in vitro to the tumor cell of acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type.

Stir-baked RHIZOMA SPARGANII with vinegar: Rhizoma Sparganii is the dry tuber of Sparganiaceae plant Rhizoma Sparganii Spaganium stoloniferum Buch.-Ham..Stir-baked RHIZOMA SPARGANII with vinegar fries dark to complexion changed according to stir-baking with vinegar.Nature and flavor: pungent, puckery, cool.Enter liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Lump in the abdomen controlled by Chinese medicine, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury.Pharmaceutical research: Rhizoma Sparganii has anticoagulant, extends thrombus formation time, shortens thrombosis, the effect of length and weight reduction, also has the trend extending prothrombin time and part Thrombokinase, reduces whole blood viscosity.

Stir-baked RHIIZOMA CURCUMAE with vinegar: be monocotyledon Zingiberaceae Zingiberaceae Rhizoma Curcumae Curcuma phaeocaulis Val., or RADIX CURCUMAE (also known as Curcuma wenyujin) C. wenyujin Y. H. Chen et C. Ling, the dry rhizome of Guangxi zedoary (also known as C. kwangsinensis) C.kwangsiensis S. lee et C. F. Liang.Stir-baked RHIIZOMA CURCUMAE with vinegar fries dark to complexion changed according to stir-baking with vinegar.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.Often join Rhizoma Sparganii.Antibacterial action: Rhizoma Curcumae volatile oil in vitro can suppress staphylococcus aureus.The growth of beta hemolytic streptococcus, escherichia coli, Bacillus typhi, vibrio cholera etc.Rhizoma Curcumae has the effect of directly killing oncocyte.Pharmaceutical research, Rhizoma Curcumae has certain effect to cardiovascular, and it is the most obvious that Rhizoma Curcumae increases acting in drug for invigorating blood circulation and eliminating stasis of femoral artery blood flow, and Rhizoma Curcumae also has suppression platelet aggregation and antithrombotic effect.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: in side, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming, Radix Asparagi, nourishing YIN to relieve dryness Radix Ophiopogonis, lung heat clearing are promoted the production of body fluid, the above five tastes are monarch drug altogether, a few taste returns kidney channel more above, can to take care of health body from the scholar of fundamentally carrying out of patient body, kidney calming, nourishing YIN to relieve dryness, blood circulation can also be accelerated, strengthen patient's body constitution, thus reach the effect controlling and alleviate the diffusion of ovary choriocarcinoma, and then reach the object for the treatment of.Semen Coicis (parched with bran) spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, Herba Patriniae heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, Herba Solani Lyrati removing toxic substances and promoting subsidence of swelling, Radix Actinidiae Chinensis, Herba Duchesneae Indicae heat-clearing and toxic substances removing, expelling wind and removing dampness, the circulation of qi promoting of Rhizoma Curcumae Longae removing blood stasis, above Six-element is ministerial drug altogether, there is effect of heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus more, all can be used for the growth of Tumor suppression, also have the effect of anti-inflammation in addition concurrently, also further suppress the diffusion of tumor.Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide, Olibanum, Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation, Fructus Akebiae promoting blood circulation and stopping pain, hard masses softening and resolving, Nidus Vespae killing parasites for relieving itching, Herba Verbenae promoting blood circulation to remove blood stasis, Rhizoma Corydalis is invigorated blood circulation promoting the circulation of QI, and Caulis Sargentodoxae relieves internal heat eliminating carbuncle, the circulation of qi promoting of Fructus Toosendan soothing liver-QI, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema, stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar removing blood stasis, promoting the circulation of QI to relieve pain, above a few taste is adjuvant drug altogether, while increasing drug effect, do not forget nourishing YIN for suppressing the hyperactive YANG, blood circulation promoting regulates qi, strengthen the body constitution of patient, increase the resistance of patient, and then accelerate patient's improvement.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of kidney calming, nourishing YIN to relieve dryness, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, effectively can control growth and the diffusion of cancerous cell, and then reach and alleviate and treat the effect of ovary choriocarcinoma.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Codonopsis 15-25 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Fructus Schisandrae Chinensis 7-17 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 7-17 part, Semen Coicis (parched with bran) 25-35 part, Herba Patriniae 15-25 part, Herba Solani Lyrati 10-20 part, Radix Actinidiae Chinensis 10-20 part, Herba Duchesneae Indicae 13-23 part, Rhizoma Curcumae Longae 10-20 part, Radix Sophorae Flavescentis 7-17 part, Olibanum 4-14 part, Myrrha 4-14 part, Fructus Akebiae 10-20 part, Nidus Vespae 10-20 part, Herba Verbenae 7-17 part, Rhizoma Corydalis 13-23 part, Caulis Sargentodoxae 15-25 part, Fructus Toosendan 10-20 part, Herba Hedyotidis Diffusae 19-29 part, stir-baked RHIZOMA SPARGANII with vinegar 10-20 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-20 part, Radix Glycyrrhizae 3-9 part.

Wherein be preferably: Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 15 parts, Radix Ophiopogonis 12 parts, Semen Coicis (parched with bran) 30 parts, Herba Patriniae 20 parts, Herba Solani Lyrati 15 parts, Radix Actinidiae Chinensis 15 parts, Herba Duchesneae Indicae 18 parts, 15 parts, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis 12 parts, Olibanum 9 parts, Myrrha 9 parts, Fructus Akebiae 15 parts, Nidus Vespae 15 parts, Herba Verbenae 12 parts, Rhizoma Corydalis 18 parts, Caulis Sargentodoxae 20 parts, Fructus Toosendan 15 parts, Herba Hedyotidis Diffusae 24 parts, stir-baked RHIZOMA SPARGANII with vinegar 15 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 15 parts, Radix Glycyrrhizae 6 parts.

Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is decoction, and its preparation method is as follows:

Step one: by weight proportion of the present invention, take Radix Codonopsis, Radix Asparagi, Radix Ophiopogonis, Radix Actinidiae Chinensis, Rhizoma Curcumae Longae, marmite put into by Radix Sophorae Flavescentis, add the water of 2-3 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, add Herba Patriniae, Herba Solani Lyrati, Herba Duchesneae Indicae, Herba Verbenae, Rhizoma Corydalis, Caulis Sargentodoxae, Herba Hedyotidis Diffusae and the Fructus Schisandrae Chinensis wrapped, Fructus Akebiae, Fructus Toosendan decocts 20 minutes, finally add Olibanum, Myrrha, Nidus Vespae, Radix Glycyrrhizae decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, for subsequent use,

Step 2: by weight proportion of the present invention, takes Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis (parched with bran), stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar carries out pulverizing, being ground to 120 mesh sieves, for subsequent use;

Step 3: by the medicinal liquid in the medicated powder Homogeneous phase mixing to step one in step 2, both the Chinese medicine decoction of alleviation ovary choriocarcinoma of the present invention.

Medicine of the present invention has effect of kidney calming, nourishing YIN to relieve dryness, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, and anticancer diffusion, strengthen patient's body constitution, cheap, have no side effect, do not perform the operation, no pain, the mode that this Chinese medicine preparation adopts is treated and can be reduced Western medicine and chemicotherapy to the injury of patient body, alleviates the slight illness of patient, according to clinical 60 routine patient view's statistics, use medicine of the present invention the total effective rate course for the treatment of 81.7%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Fructus Schisandrae Chinensis 7 parts, Radix Asparagi 10 parts, Radix Ophiopogonis 7 parts, Semen Coicis (parched with bran) 25 parts, Herba Patriniae 15 parts, Herba Solani Lyrati 10 parts, Radix Actinidiae Chinensis 10 parts, Herba Duchesneae Indicae 13 parts, 10 parts, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis 7 parts, Olibanum 4 parts, Myrrha 4 parts, Fructus Akebiae 10 parts, Nidus Vespae 10 parts, Herba Verbenae 7 parts, Rhizoma Corydalis 13 parts, Caulis Sargentodoxae 15 parts, Fructus Toosendan 10 parts, Herba Hedyotidis Diffusae 19 parts, stir-baked RHIZOMA SPARGANII with vinegar 10 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 10 parts, Radix Glycyrrhizae 3 parts.

Embodiment two, Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 15 parts, Radix Ophiopogonis 12 parts, Semen Coicis (parched with bran) 30 parts, Herba Patriniae 20 parts, Herba Solani Lyrati 15 parts, Radix Actinidiae Chinensis 15 parts, Herba Duchesneae Indicae 18 parts, 15 parts, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis 12 parts, Olibanum 9 parts, Myrrha 9 parts, Fructus Akebiae 15 parts, Nidus Vespae 15 parts, Herba Verbenae 12 parts, Rhizoma Corydalis 18 parts, Caulis Sargentodoxae 20 parts, Fructus Toosendan 15 parts, Herba Hedyotidis Diffusae 24 parts, stir-baked RHIZOMA SPARGANII with vinegar 15 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 15 parts, Radix Glycyrrhizae 6 parts.

Embodiment three, Radix Codonopsis 25 parts, Rhizoma Atractylodis Macrocephalae (parched) 25 parts, Fructus Schisandrae Chinensis 17 parts, Radix Asparagi 20 parts, Radix Ophiopogonis 17 parts, Semen Coicis (parched with bran) 35 parts, Herba Patriniae 25 parts, Herba Solani Lyrati 20 parts, Radix Actinidiae Chinensis 20 parts, Herba Duchesneae Indicae 23 parts, 20 parts, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis 17 parts, Olibanum 14 parts, Myrrha 14 parts, Fructus Akebiae 20 parts, Nidus Vespae 20 parts, Herba Verbenae 17 parts, Rhizoma Corydalis 23 parts, Caulis Sargentodoxae 25 parts, Fructus Toosendan 20 parts, Herba Hedyotidis Diffusae 29 parts, stir-baked RHIZOMA SPARGANII with vinegar 20 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 20 parts, Radix Glycyrrhizae 9 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 60 example for medical treatment, 40 years old mean age, course of disease some months is not by several years etc.

Two, Therapeutic Method:

According to Medications Example two of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, takes at twice, within 30th, is a course for the treatment of.

Three, efficacy assessment standard:

1, effective: body constitution strengthens, and the clinical symptoms such as stomachache, irregular vagina bleeding, heating disappears completely, and lab testing tumor reduces to some extent, and other positions do not find nascent tumor.

2, effective: body constitution strengthens to some extent, and the clinical symptoms such as stomachache, irregular vagina bleeding, heating disappears substantially, and lab testing tumor does not increase, other positions do not find nascent tumor.

3, invalid: symptom does not change, ovary portion tumor increases, or other positions find nascent tumor.

Four, therapeutic outcome statistics

Wherein: total effective rate=obvious effective rate+effective percentage

Shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in control and alleviation ovary choriocarcinoma, is worth promoting in clinical practice.

Model case and curative effect:

Case one, grandson patient, female, 32 years old, patient has the phenomenon of irregular vagina bleeding in the recent period always, and with the phenomenon of stomachache, patient removes examination in hospital, be diagnosed as ovary choriocarcinoma, patient is unwilling to be treated surgically, determine to adopt Chinese medicine expectant treatment, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after patient takes a course for the treatment of, patient mental's state, irregular vagina bleeding etc. fade away, continue to take two courses for the treatment of, patient clinical symptom disappears substantially, examination in hospital tumor is gone obviously to reduce, patient continues to take a period of time, the state of an illness is controlled, tumor reduces not diffusing phenomenon gradually.

Case two, patient Wu, female, 40 years old, patient suffers from abdominal pain, abnormal vaginal bleeding, abdominal part has the sensation of enclosed mass, and with the phenomenon of heating, health occurs significantly uncomfortable, remove examination in hospital, lab testing final result is ovary choriocarcinoma, family numbers of patients does not tell patient's truth, do not wish that patient is put, chemotherapy and operative treatment, wish to conceal conditions of patients, so adopt the method for the treatment of by Chinese herbs, patient adopts made preparation in the embodiment of the present invention two, and selected preparation method, after several days, heating paresthesia obviously alleviates, stomachache is also eased, continue two courses for the treatment of of use, the phenomenon of patient's irregular vagina bleeding disappears completely, body constitution also takes a turn for the better to some extent, patient is another directly adhere to taking a period of time after, hospital is gone to check, find that tumor disappears substantially, do not find nascent tumor.

Claims (4)

1. alleviate the Chinese medicine preparation of ovary choriocarcinoma for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Codonopsis 15-25 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Fructus Schisandrae Chinensis 7-17 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 7-17 part, Semen Coicis (parched with bran) 25-35 part, Herba Patriniae 15-25 part, Herba Solani Lyrati 10-20 part, Radix Actinidiae Chinensis 10-20 part, Herba Duchesneae Indicae 13-23 part, Rhizoma Curcumae Longae 10-20 part, Radix Sophorae Flavescentis 7-17 part, Olibanum 4-14 part, Myrrha 4-14 part, Fructus Akebiae 10-20 part, Nidus Vespae 10-20 part, Herba Verbenae 7-17 part, Rhizoma Corydalis 13-23 part, Caulis Sargentodoxae 15-25 part, Fructus Toosendan 10-20 part, Herba Hedyotidis Diffusae 19-29 part, stir-baked RHIZOMA SPARGANII with vinegar 10-20 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-20 part, Radix Glycyrrhizae 3-9 part.

2. the Chinese medicine preparation of alleviation ovary choriocarcinoma according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 15 parts, Radix Ophiopogonis 12 parts, Semen Coicis (parched with bran) 30 parts, Herba Patriniae 20 parts, Herba Solani Lyrati 15 parts, Radix Actinidiae Chinensis 15 parts, Herba Duchesneae Indicae 18 parts, 15 parts, Rhizoma Curcumae Longae, Radix Sophorae Flavescentis 12 parts, Olibanum 9 parts, Myrrha 9 parts, Fructus Akebiae 15 parts, Nidus Vespae 15 parts, Herba Verbenae 12 parts, Rhizoma Corydalis 18 parts, Caulis Sargentodoxae 20 parts, Fructus Toosendan 15 parts, Herba Hedyotidis Diffusae 24 parts, stir-baked RHIZOMA SPARGANII with vinegar 15 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 15 parts, Radix Glycyrrhizae 6 parts.

3. the Chinese medicine preparation of alleviation ovary choriocarcinoma according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. alleviate the preparation method of the Chinese medicine preparation of ovary choriocarcinoma for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, take Radix Codonopsis, Radix Asparagi, Radix Ophiopogonis, Radix Actinidiae Chinensis, Rhizoma Curcumae Longae, marmite put into by Radix Sophorae Flavescentis, add the water of 2-3 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, add Herba Patriniae, Herba Solani Lyrati, Herba Duchesneae Indicae, Herba Verbenae, Rhizoma Corydalis, Caulis Sargentodoxae, Herba Hedyotidis Diffusae and the Fructus Schisandrae Chinensis wrapped, Fructus Akebiae, Fructus Toosendan decocts 20 minutes, finally add Olibanum, Myrrha, Nidus Vespae, Radix Glycyrrhizae decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, for subsequent use, step 2: by weight proportion of the present invention, takes Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis (parched with bran), stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar carries out pulverizing, being ground to 120 mesh sieves, for subsequent use, step 3: by the medicinal liquid in the medicated powder Homogeneous phase mixing to step one in step 2, both the Chinese medicine decoction of alleviation ovary choriocarcinoma of the present invention.