CN110507784A - A kind of carcinoid Chinese medicine detumescence spray and preparation method thereof - Google Patents

A kind of carcinoid Chinese medicine detumescence spray and preparation method thereof Download PDF

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CN110507784A
CN110507784A CN201910708631.1A CN201910708631A CN110507784A CN 110507784 A CN110507784 A CN 110507784A CN 201910708631 A CN201910708631 A CN 201910708631A CN 110507784 A CN110507784 A CN 110507784A
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parts
chinese medicine
spray
carcinoid
detumescence
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庄瑞新
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Zhejiang Youkelili Pharmaceutical Technology Co Ltd
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Zhejiang Youkelili Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/902Sparganiaceae (Bur-reed family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a kind of carcinoid Chinese medicine detumescence sprays and preparation method thereof, a kind of carcinoid Chinese medicine detumescence spray is made of Chinese medicine material and white wine, and the Chinese medicine material includes following component: Typhonium giganteum, unprocessed Arisaema erubescens, dried pinellia, olibanum, myrrh, centipede, scorpion, semen brassicae, the seed of garden balsam, Chinese blister beetle, Sculellaria barbata, Radix Aconiti Kusnezoffii, Radix Aconiti, trigone and curcuma zedoary.The present invention passes through the cooperation between raw material, plays synergistic effect, and Traditional Chinese medicinal spray obtained is made to have effects that clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, swelling and pain relieving, is conducive to stablize and reduce knurl, inhibits the growth of tumour cell, to play the role of quickly reducing swelling.

Description

A kind of carcinoid Chinese medicine detumescence spray and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, more specifically, it is related to a kind of carcinoid Chinese medicine detumescence spray Agent and preparation method thereof.
Background technique
Benign tumour refers to that the cell of certain tissues in body is abnormal proliferation, is in expansive growth, slow growth;Tumor How spherical in shape body is, nodositas, and coating is around commonly formed, obvious with normal tissue boundary, does not invade neighbouring normal tissue generally It is interior, it is smaller to the harm of body;If but benign tumour occur canceration, consequence is identical as malignant tumour, therefore still needs to the moment Benign tumour is treated.Usually there are operative treatment and drug therapy, operative treatment to carcinoid treatment method at present Be using operation by the way of benign tumour is cut off, will not generally shift after excision, can seldom recur, but its Wound is larger, and convalescence is longer, and biggish pain and heavier financial burden can be caused to patient.And when using drug therapy, The pain sensation of usual patient is lighter, lower to the conflict degree of drug, therefore is easier to be accepted;Drug therapy root at present Western medicine and Chinese medicine can be divided into according to its ingredient, the curative effect of traditional Western medicine is fast, treatment cycle is shorter, but side effects of pharmaceutical drugs compared with Greatly, the normal tissue of body may be damaged, although and its side effect of traditional Chinese medicine is lower, its curative effect is poor, suffer from Person needs to endure the ailing pressure of long period;Therefore the mode of drug therapy is still not ideal enough at present, it is still desirable to a kind of For the short Chinese drugs agentia of carcinoid good effect, treatment cycle.
Summary of the invention
One of the objects of the present invention is to provide a kind of carcinoid Chinese medicine detumescence sprays, pass through matching between raw material It closes, plays synergistic effect, Traditional Chinese medicinal spray obtained is made to have effects that clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, swelling and pain relieving, be conducive to steady Fixed and diminution knurl, inhibits the growth of tumour cell, to play the role of quickly reducing swelling.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of carcinoid Chinese medicine detumescence spray, is made, the Chinese medicine material includes following weight of Chinese medicine material and white wine Part component: 4900-5100 parts of Typhonium giganteum, 900-1100 parts of unprocessed Arisaema erubescens, 900-1100 parts of dried pinellia, 90-110 parts of olibanum, 90-110 parts of myrrh, 1400-1600 parts of centipede, 400-600 parts of scorpion, 400-600 parts of semen brassicae, the seed of garden balsam 400-600 parts, spot 400-600 parts of Chinese blister beetle, 400-600 parts of Sculellaria barbata, 400-600 parts of Radix Aconiti Kusnezoffii, 400-600 parts of Radix Aconiti, 400-600 parts of trigone and 400-600 parts of curcuma zedoary.
By using above-mentioned technical proposal, according to the pathogenesis of traditional Chinese medical theory and tumor disease, using dialectical treatmert Compatibility is carried out, wherein the effect of each component of Chinese medicine material is as follows:
Typhonium giganteum (Classification system: Typhonium giganteum Engl.) Araeceae Typhonium Schott herbaceos perennial, Have effects that detoxicating and resolving a mass, the toxicity of the other components in raw material can be alleviated;
Unprocessed Arisaema erubescens, crude drug decontamination are cleaned and are dried, and the person of being used as medicine is sliced, and property is bitter, acrid in flavour and warm in nature, wherein the PEARLITOL 25C contained at Point, there is apparent effect to the growth of tumour;
The tuber of pinellia is the dilute alcohol and infusion or its polysaccharide component, biology of the stem tuber tuber of pinellia of the Araeceae herbaceos perennial tuber of pinellia Alkali has wide antitumor action;
Olibanum is olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener Boswellia The resin of bhaurdajiana Birdw. bark exudation has the effect of promoting blood circulation analgesic therapy, detumescence and promoting granulation, blood-activating and qi-promoting;
Myrrh is olive subject plant Chinese violet tree Commiphora myrrha Engl. or breathes out Chinese violet tree Commiphora molmol Ngl. dry resin has effects that scattered stasis pain, detumescence and promoting granulation;
Centipede is the drying of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH Scolopendra subspinipes mutilans L.Koch Body, the pungent taste temperature of property, has effects that relieve the wind syndrome antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation;
The pungent taste of scorpion property is flat, and medicinal scorpio has dispersing pathogen accumulation and antitumor effect;
Semen brassicae, Latin literary fame Semen sinapis, acrid flavour is peppery, the function with antimycotic, anti-irritation and mass dissipating and swelling eliminating Effect;
The seed of garden balsam is the seed of Balsaminaceae plant phoenix celestial being, slight bitter, acrid in flavour and warm in nature, with blood-breaking disperse accumulation, resolving hard lump, antibacterial and The effect of anticancer;
Chinese blister beetle is Meloidae insect Mylabris phalarata Mylabris phalerata Pallas or yellow black mylabris cichorii Mylabris The effect of malicious phagedenoma and anticancer, is attacked in the hirudo leech of cichorii Linnaeus, blood-breaking detumescence;
Sculellaria barbata, scientific name: Scutellaria barbata D.Don, it is cold in nature sour, there is clearing heat and detoxicating, promoting blood circulation, detumescence The functions such as analgesic, anticancer;
Radix Aconiti Kusnezoffii is the root tuber of the Ranunculaceae herbaceos perennial rhizome of Chinese monkshood (wild species) or the northern rhizome of Chinese monkshood, and pungent, bitter, heat contains the rhizome of Chinese monkshood Alkali has effects that warming channel and expelling cold, swelling and pain relieving;
Radix Aconiti, latin name RadixAconiti have analgesia, anti-inflammatory effect;
Trigone is the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloni erum, Buch-Ham, has The effect of breaking blood and promoting the circulation of qi, clearing stagnation and killing pain;
Curcuma zedoary, Latin name: Curcuma zedoaria (Christm.) Rosc, pungent, bitter, temperature has promoting qi circulation and relieving pain, blood-breaking Dissolving stasis and antitumor effect;
Using the Typhonium giganteum with antitumor efficacy, unprocessed Arisaema erubescens, dried pinellia, the seed of garden balsam, Sculellaria barbata, curcuma zedoary, and with promoting menstruation Active, dispersing pathogen accumulation effect centipede, scorpion, Chinese blister beetle have activating microcirculation and removing stasis medicinal, the olibanum of swelling and pain relieving, myrrh, semen brassicae, life Radix aconiti agrestis, Radix Aconiti, trigone match, and play synergistic effect, and Traditional Chinese medicinal spray obtained has clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, detumescence The effect of analgesic, is conducive to stablize and reduce knurl, inhibits the growth of tumour cell, to play the role of quickly reducing swelling.
Further, the Chinese medicine material includes the component of following parts by weight: 5000 parts of Typhonium giganteum, unprocessed Arisaema erubescens 1000 Part, 1000 parts of dried pinellia, 100 parts of olibanum, 100 parts of myrrh, 1500 parts of centipede, 500 parts of scorpion, 500 parts of semen brassicae, the seed of garden balsam 500 parts, 500 parts of Chinese blister beetle, 500 parts of Sculellaria barbata, 500 parts of Radix Aconiti Kusnezoffii, 500 parts of Radix Aconiti, 500 parts of trigone and 500 parts of curcuma zedoary.
Further, the weight ratio of the Chinese medicine material and white wine is 1:5.
Further, the white wine is the white wine that alcohol content is 65%vol.
By using above-mentioned technical proposal, the alcohol in white wine has permeability, can relatively easily enter medicinal material tissue In cell, dissolution is played, promotes displacement and diffusion, is conducive to improve leaching velocity and leaching effect, and passes through alcohol High osmosis can be such that traditional Chinese medicine ingredients therein quickly reach at tumour, and in the presence of alcohol, can increase medicine Object active constituent is held time, and is conducive to improve drug effect.
Further, the white wine is sorghum liquor.
By using above-mentioned technical proposal, sorghum liquor is made using sorghum, liquor made from sorghum have dredge the channels, promoting the circulation of qi With the effect of blood, drug can be made to play better effect.
The second object of the present invention is to provide a kind of preparation method of carcinoid Chinese medicine detumescence spray.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of preparation method of carcinoid Chinese medicine detumescence spray, includes the following steps:
S1: based on parts by weight, take 4900-5100 parts of Typhonium giganteum, 900-1100 parts of unprocessed Arisaema erubescens, 900-1100 parts of dried pinellia, It is 90-110 parts of olibanum, 90-110 parts of myrrh, 1400-1600 parts of centipede, 400-600 parts of scorpion, 400-600 parts of semen brassicae, acute 400-600 parts sub-, 400-600 parts of Chinese blister beetle, 400-600 parts of Sculellaria barbata, 400-600 parts of Radix Aconiti Kusnezoffii, 400-600 parts of Radix Aconiti, three 400-600 parts of rib and 400-600 parts of curcuma zedoary, after its crushing grinding, it is spare to obtain traditional Chinese medicine powder;
S2: taking 500 parts of white wine, and the traditional Chinese medicine powder in 100 parts of S1 is added thereto, after soak at room temperature 30-45 days, filtering residue precipitating Afterwards, Chinese medicine detumescence spray is obtained.
Further, the fineness of the traditional Chinese medicine powder is 200-300 mesh.
Further, for S2 during immersion, stirring 1 time, stirs 5-10min every time daily.
Further, the white wine is the white wine that alcohol content is 65%vol.
In conclusion the present invention has the advantages that compared with the prior art
Using the Typhonium giganteum with antitumor efficacy, unprocessed Arisaema erubescens, dried pinellia, the seed of garden balsam, Sculellaria barbata, curcuma zedoary, and with promoting menstruation Active, dispersing pathogen accumulation effect centipede, scorpion, Chinese blister beetle have activating microcirculation and removing stasis medicinal, the olibanum of swelling and pain relieving, myrrh, semen brassicae, life Radix aconiti agrestis, Radix Aconiti, trigone match, and play synergistic effect, and Traditional Chinese medicinal spray obtained has clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, detumescence The effect of analgesic, is conducive to stablize and reduce knurl, inhibits the growth of tumour cell, to play the role of quickly reducing swelling.
Specific embodiment
Invention is further described in detail below.
One, embodiment
Embodiment 1: a kind of carcinoid Chinese medicine detumescence spray is prepared with the following method:
S1: Typhonium giganteum 5000g, unprocessed Arisaema erubescens 1000g, dried pinellia 1000g, olibanum 100g, myrrh 100g, centipede 1500g, scorpion are taken Sub- 400-600g, semen brassicae 500g, seed of garden balsam 500g, Chinese blister beetle 500g, Sculellaria barbata 500g, Radix Aconiti Kusnezoffii 500g, Radix Aconiti 500g, three It is spare to obtain the traditional Chinese medicine powder that fineness is 200 mesh after its crushing grinding by rib 500g and curcuma zedoary 500g;
S2: taking 500g alcohol content is the sorghum liquor of 65%vol, and the traditional Chinese medicine powder in 100gS1, soak at room temperature are added thereto It after 30 days, during which stirs daily 1 time, stirs 5min every time, after residue precipitating is filtered after immersion, obtain Chinese medicine detumescence spray Agent.
Embodiment 2: a kind of carcinoid Chinese medicine detumescence spray is prepared with the following method:
S1: Typhonium giganteum 4900g, unprocessed Arisaema erubescens 900g, dried pinellia 900g, olibanum 90g, myrrh 90g, centipede 1400g, scorpion are taken 400g, semen brassicae 400g, seed of garden balsam 400g, Chinese blister beetle 400g, Sculellaria barbata 400g, Radix Aconiti Kusnezoffii 400g, Radix Aconiti 400g, trigone 400g And it is spare to obtain the traditional Chinese medicine powder that fineness is 200 mesh after its crushing grinding by curcuma zedoary 400g;
S2: taking 500g alcohol content is the sorghum liquor of 65%vol, and the traditional Chinese medicine powder in 100gS1, soak at room temperature are added thereto It after 30 days, during which stirs daily 1 time, stirs 6min every time, after residue precipitating is filtered after immersion, obtain Chinese medicine detumescence spray Agent.
Embodiment 3: a kind of carcinoid Chinese medicine detumescence spray is prepared with the following method:
S1: Typhonium giganteum 5100g, unprocessed Arisaema erubescens 1100g, dried pinellia 1100g, olibanum 110g, myrrh 110g, centipede 1600g, scorpion are taken Sub- 600g, semen brassicae 600g, seed of garden balsam 600g, Chinese blister beetle 600g, Sculellaria barbata 600g, Radix Aconiti Kusnezoffii 600g, Radix Aconiti 600g, trigone It is spare to obtain the traditional Chinese medicine powder that fineness is 200 mesh after its crushing grinding by 600g and curcuma zedoary 600g;
S2: taking 500g alcohol content is the sorghum liquor of 65%vol, and the traditional Chinese medicine powder in 100gS1, soak at room temperature are added thereto It 45 days, during which stirs daily 1 time, stirs 10min every time, after residue precipitating is filtered after immersion, obtain Chinese medicine detumescence spray.
Two, performance test
1. animal acute toxicity test
The white big ear rabbit of health is taken, weight is 2.0 ± 0.2kg, before the test the hair cutting on the right side of the backbone of back;By 16 Rabbit is randomly divided into 4 groups, every group of half male and half female, wherein three groups are experimental group, as experimental group 1, experimental group 2 and experimental group 3, Another group is control group;Using the detumescence spray of Chinese medicine made from embodiment 1- embodiment 3 as sample, it is sprayed on experimental group 1- respectively On the skin of the rabbit depilation of experimental group 3, every 12h spraying is primary, sprays 0.5ml every time;Control group sprays grade equivalent daily Physiological saline, be observed continuously 7 days, record the skin condition and average weight growth rate of rabbit, test result is shown in table 1。
Influence of 1 Chinese medicine of the table detumescence spray to rabbit skin irritation and weight
When Chinese medicine prepared by the present invention detumescence spray is used for skin it can be seen from 1 data of table, skin will not be caused to generate erythema And the phenomenon that oedema, there is lower irritation, and the body weight increase of experimental group rabbit and control group no significant difference, say Bright Chinese medicine detumescence of the invention will not influence the normal growth of rabbit in a short time.
2. long-term toxicity test for animals
80 healthy rats are taken, weight is 200 ± 20g, is randomly divided into 4 groups, every group of half male and half female, wherein three groups are real Group, as experimental group 1, experimental group 2 and experimental group 3 are tested, another group is control group;In made from embodiment 1- embodiment 3 Medicine reduces swelling spray as sample, is sprayed on the skin of rat depilation of experimental group 1- experimental group 3 respectively, and every 12h spraying is primary, Spraying 0.2ml every time, continuous two months, control group sprayed the physiological saline of grade equivalent daily, the daily spirit for observing rat, Diet and active state start to test the latter moon and two months the body weight growth rate of rat respectively and use coating in medication Skin state puts to death half experimental rat, its each internal organs (heart, liver, lung, kidney, reproductive organs) and medication skin is taken to do pathologic It checks, test result is shown in table 2.
Table 2
Chinese medicine prepared by the present invention detumescence spray will not cause it when used for a long time for rat it can be seen from 2 data of table There is exception in spirit, diet and active state, and medication skin is not in erythema, oedema situation, and disease will not occur for each internal organs Become, the body weight growth rate and control group no significant difference of rat in experimental group, illustrates Chinese medicine detumescence spray of the invention to animal Nonhazardous effect, will not generate excessive influence to the growth and development of animal.
3. clinical efficacy
Clinical data: the present invention carries out clinical observation with carcinoid patient to 1238, and wherein tumor of breast is 203 Example, fibroid 145, stomach neoplasm 252, liver tumour 176, kidney neoplasms 141, intestinal tumor 134, thyroid tumors 187;The Chinese medicine detumescence spray spraying prepared using embodiment 1 is at the affected skin of patient, and spraying three times, is sprayed every time every time Apply 2-4ml, medication detects its therapeutic effect after 2 months, original symptom disappears after wherein clinical cure refers to treatment, it is effective refer to control Original symptom partial disappearance after treatment, effectively refer to treatment after original symptom mitigated, refer in vain treatment after original symptom without Test result is shown in table 3 by significant change.
Table 3
Clinical cure It is effective Effectively In vain
Tumor of breast 98 61 38 4
Fibroid 77 33 31 4
Stomach neoplasm 137 65 43 7
Liver tumour 93 46 36 1
Kidney neoplasms 73 38 26 5
Intestinal tumor 69 46 15 4
Thyroid tumors 94 55 38 0
The Chinese medicine prepared by the present invention detumescence spray for treating tumor of breast, fibroid, stomach it can be seen from 3 data of table When tumour, liver tumour, kidney neoplasms, intestinal tumor, thyroid tumors, treated effect can achieve 98.0%, illustrate the present invention Chinese medicine detumescence spray to benign tumour have well detumescence effect.
The following are the typical cases in above-mentioned patient:
Lee, female 43 years old, suffer from tumor of breast, there is the tumour of 3.5 × 3.3cm at right breast;It is daily to be prepared using the present invention Chinese medicine detumescence spray spraying illing skin spray 2ml every time 3 times a day, after medication 2 months, tumor disappearance, finger pressing Without obvious foreign body sensation, after being discontinued 3 months, follow-up health does not recur.
Zhang, female 48 years old, suffer from fibroid, and tumor size is 5.5cm × 5.2cm, is used in prepared by the present invention daily Medicine detumescence spray spraying illing skin sprays 2ml 3 times a day every time, after medication 4 months, tumor disappearance, and after being discontinued 3 months, Follow-up health does not recur.
Mr. Wang, male 46 years old, suffers from stomach neoplasm, sprays illing skin using Chinese medicine prepared by the present invention detumescence spray daily, often It 3 times, 2ml is sprayed every time, and after medication 4 months, tumor disappearance, after being discontinued 3 months, follow-up health does not recur.
Liu, male, 54 years old, suffers from liver tumour, sprays illing skin using Chinese medicine prepared by the present invention detumescence spray daily, often It 3 times, 2ml is sprayed every time, and after medication 5 months, tumor disappearance, after being discontinued 3 months, follow-up health does not recur.
Hu, male, 61 years old, suffers from kidney neoplasms, sprays illing skin using Chinese medicine prepared by the present invention detumescence spray daily, often It 3 times, 2ml is sprayed every time, and after medication 5 months, tumor disappearance, after being discontinued 3 months, follow-up health does not recur.
Mr. Yu, male, 45 years old, suffers from intestinal tumor, sprays illing skin using Chinese medicine prepared by the present invention detumescence spray daily, often It 3 times, 2ml is sprayed every time, and after medication 4 months, tumor disappearance, after being discontinued 3 months, follow-up health does not recur.
Zhao, female 35 years old, suffer from thyroid tumors, spray affected part skin using Chinese medicine prepared by the present invention detumescence spray daily Skin sprays 2ml 3 times a day every time, and after medication 2 months, tumor disappearance, finger pressing is without obvious foreign body sensation, after being discontinued 3 months, Follow-up health does not recur.
This specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art Member can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as at this All by the protection of Patent Law in the scope of the claims of invention.

Claims (9)

  1. The spray 1. a kind of carcinoid Chinese medicine is reduced swelling, is made, it is characterised in that: the Chinese medicine material of Chinese medicine material and white wine Component including following parts by weight: 4900-5100 parts of Typhonium giganteum, 900-1100 parts of unprocessed Arisaema erubescens, 900-1100 parts of dried pinellia, cream 90-110 parts fragrant, 90-110 parts of myrrh, 1400-1600 parts of centipede, 400-600 parts of scorpion, 400-600 parts of semen brassicae, the seed of garden balsam 400-600 parts, 400-600 parts of Chinese blister beetle, 400-600 parts of Sculellaria barbata, 400-600 parts of Radix Aconiti Kusnezoffii, 400-600 parts of Radix Aconiti, trigone 400-600 parts and 400-600 parts of curcuma zedoary.
  2. The spray 2. a kind of carcinoid Chinese medicine according to claim 1 is reduced swelling, it is characterised in that: the Chinese medicine material packet Include the component of following parts by weight: 5000 parts of Typhonium giganteum, 1000 parts of unprocessed Arisaema erubescens, 1000 parts of dried pinellia, 100 parts of olibanum, myrrh 100 Part, 1500 parts of centipede, 500 parts of scorpion, 500 parts of semen brassicae, impetuous 500 parts, 500 parts of Chinese blister beetle, 500 parts of Sculellaria barbata, Radix Aconiti Kusnezoffii 500 parts, 500 parts of Radix Aconiti, 500 parts of trigone and 500 parts of curcuma zedoary.
  3. The spray 3. a kind of carcinoid Chinese medicine according to claim 1 is reduced swelling, it is characterised in that: the Chinese medicine material with The weight ratio of white wine is 1:5.
  4. The spray 4. a kind of carcinoid Chinese medicine according to claim 1 is reduced swelling, it is characterised in that: the white wine is alcohol Content is the white wine of 65%vol.
  5. The spray 5. a kind of carcinoid Chinese medicine according to claim 1 is reduced swelling, it is characterised in that: the white wine is sorghum White wine.
  6. 6. a kind of preparation method of carcinoid Chinese medicine detumescence spray, characterized by the following steps:
    S1: based on parts by weight, take 4900-5100 parts of Typhonium giganteum, 900-1100 parts of unprocessed Arisaema erubescens, 900-1100 parts of dried pinellia, It is 90-110 parts of olibanum, 90-110 parts of myrrh, 1400-1600 parts of centipede, 400-600 parts of scorpion, 400-600 parts of semen brassicae, acute 400-600 parts sub-, 400-600 parts of Chinese blister beetle, 400-600 parts of Sculellaria barbata, 400-600 parts of Radix Aconiti Kusnezoffii, 400-600 parts of Radix Aconiti, three 400-600 parts of rib and 400-600 parts of curcuma zedoary, after its crushing grinding, it is spare to obtain traditional Chinese medicine powder;
    S2: taking 500 parts of white wine, and the traditional Chinese medicine powder in 100 parts of S1 is added thereto, after soak at room temperature 30-45 days, filtering residue precipitating Afterwards, Chinese medicine detumescence spray is obtained.
  7. 7. a kind of preparation method of carcinoid Chinese medicine detumescence spray according to claim 6, it is characterised in that: described The fineness of traditional Chinese medicine powder is 200-300 mesh.
  8. 8. a kind of preparation method of carcinoid Chinese medicine detumescence spray according to claim 6, it is characterised in that: S2 exists During immersion, stirring 1 time, stirs 5-10min every time daily.
  9. 9. a kind of preparation method of carcinoid Chinese medicine detumescence spray according to claim 6, it is characterised in that: described White wine is the white wine that alcohol content is 65%vol.
CN201910708631.1A 2019-08-01 2019-08-01 A kind of carcinoid Chinese medicine detumescence spray and preparation method thereof Pending CN110507784A (en)

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Publication number Priority date Publication date Assignee Title
CN1101559A (en) * 1993-10-14 1995-04-19 刘彦彬 Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method
CN1252301A (en) * 1999-10-10 2000-05-10 黄晓维 Cancer eliminating ointment compounding process
CN106552143A (en) * 2017-02-07 2017-04-05 肖怀法 The medicine for the treatment of tumor
CN106943572A (en) * 2017-03-31 2017-07-14 上海世道健康科技有限公司 It is a kind of to treat Chinese medicine composition of Cystic hyperplasia breast and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101559A (en) * 1993-10-14 1995-04-19 刘彦彬 Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method
CN1252301A (en) * 1999-10-10 2000-05-10 黄晓维 Cancer eliminating ointment compounding process
CN106552143A (en) * 2017-02-07 2017-04-05 肖怀法 The medicine for the treatment of tumor
CN106943572A (en) * 2017-03-31 2017-07-14 上海世道健康科技有限公司 It is a kind of to treat Chinese medicine composition of Cystic hyperplasia breast and preparation method thereof

Non-Patent Citations (2)

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张俊莉: "《腰腿痛简易疗法》", 31 March 2013, 西安交通大学出版社 *
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