CN1907371B - Chinese patent medicine for treating anus cryptitis and hemorrhoid - Google Patents
Chinese patent medicine for treating anus cryptitis and hemorrhoid Download PDFInfo
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- CN1907371B CN1907371B CN200610019797A CN200610019797A CN1907371B CN 1907371 B CN1907371 B CN 1907371B CN 200610019797 A CN200610019797 A CN 200610019797A CN 200610019797 A CN200610019797 A CN 200610019797A CN 1907371 B CN1907371 B CN 1907371B
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Abstract
Disclosed is a Chinese medicament for treating cryptitis which is prepared from the following medicinal herbs (by weight ratio): artificial ox gallstone 11-13g, yellow corktree bark 300-400g, coptis root 150-250g, rhubarb horsetails 50-150g, myrrh 50-100g, borneo camphor 10-20g, triglyceride 1000-1500g.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese patent medicine for the treatment of anal cryptitis, hemorrhoid disease.
Background technology
At present, anal cryptitis and hemorrhoid disease are surgical common disease, frequently-occurring disease, and sickness rate is higher in the physical labourer, and common saying claims " ten people, nine hemorrhoid ".Show that according to the investigation of health net hemorrhoid patient accounts for 62.3% of healthy population.The anus crypts is the alveole that is formed by the mucosa between rectal columns and the anal valves, and bag mouth makes progress, easily presence of residual feces, antibacterial assembles growth, can cause liver abscess along hemorrhoid angular vein clump through portal vein in case infect, also can outside hemorrhoid, enter postcava by venous plexus, cause systemic infection.Some patient causes perianorecrtal abscess because malpractice, even forms anal fistula, causes that excrement is smelly to be overflowed, and causes bigger harm to health of people.And the medicine for the treatment of this type of disease at present is few, and uncertain therapeutic efficacy is fixed.Particularly the curative effect of some oral medicine is more undesirable, and after taking medicine, its intravital gastric acid and digestive enzyme also can produce destruction to the effect of medicine.
Summary of the invention
The object of the present invention is to provide the Chinese patent medicine that a kind of technology is easy, curative effect is treated anal cryptitis and hemorrhoid disease preferably.
Purpose of the present invention is realized by following scheme:
A kind of Chinese patent medicine for the treatment of anal cryptitis, hemorrhoid disease; it is that raw material Chinese medicine by following content is prepared from: In vitro cultured Calculus Bovis 11~13g; Cortex Phellodendri 300~400g; Rhizoma Coptidis 150~250g; Radix Et Rhizoma Rhei (charcoal) 50~150g; Myrrha (processed) 50~100g, Borneolum Syntheticum 10~20g, mixed fatty glycerides 1000~1500g.
The concrete value of above-mentioned selected each raw material Chinese medicine is: In vitro cultured Calculus Bovis 12g, and Cortex Phellodendri 350g, Rhizoma Coptidis 200g, Radix Et Rhizoma Rhei (charcoal) 100g, Myrrha (processed) 80g, Borneolum Syntheticum 15g, mixed fatty glycerides 1250g makes 1000 altogether.
The character of above-mentioned Chinese patent medicine is the bullet-shaped suppository of sepia to black, gas perfume (or spice).
The invention has the advantages that and select materials easily, found market in particular for the development and use of this new drug of In vitro cultured Calculus Bovis.Technology is easy, and pharmaceutical formulation is generally suppository, but rectally directly acts on local lesion, has overcome the drawback that oral medicine at present commonly used exists, and makes that treatment is easy, and curative effect is better.Because it has effects such as heat-clearing and toxic substances removing damp eliminating preferably, Repercusion analgesia hemostasis, so can be widely used in the anal cryptitis of dampness and heat stasis, proctalgia that the hemorrhoid disease causes, swelling, hemorrhage disease.
Through demonstrations such as for many years pharmacodynamics, clinical trials, steady quality of the present invention, safe and reliable,
Curative effect is better:
1, pharmacodynamic study:
Xylol of the present invention causes that Mice Auricle edema and rat granuloma are swollen all an obvious suppression effect.Mice hot plate method induced mice pain reaction there is the obvious suppression effect.Experiment in vitro has inhibition and killing action to golden yellow staphylococcus and streptococcus, and escherichia coli are caused the right buttocks local infection of rat significant inhibitory effect.To hemorrhage due to the mice docking tangible anastalsis arranged.
2, stability experiment:
Observing three batches of 0-24 months that keep sample of centering of the present invention trial production, the result of appraisal show its in character, differentiate, melt aspects such as becoming time limit, assay, health examination all conformance with standard stipulate.Therefore, steady quality of the present invention.
3, toxicologic study:
Can reach 8.2g/kg to its maximum dosage-feeding of rat acute toxicity test, be equivalent to 328 times of the clinical consumption of people, observe a week and do not see toxic reaction; The long term toxicity test result, continuous 4 weeks of rectally of rat (dosage be equivalent to respectively crude drug 0.25g/kg 1.25g/kg, for clinical plan with 10 times of dosage 50 times), do not see toxic reaction.
4, clinical experiment result:
Prescription of the present invention derives from the clinical practice experience, through the old docter of TCM for many years repeatedly clinical practice in anorectal diseases such as treatment anal cryptitis, hemorrhoid diseases, respond well.On the basis of clinical practice, through form improvement repeatedly, use modern scientific method, effective component extracting is made suppository, and not only volume is little, the content height, and also clinical therapeutic efficacy is better.Suppository of the present invention has clinical efficacy preferably to treatment I phase, II phase internal hemorrhoid and mixed hemorrhoid, anal cryptitis.Can obviously improve patient's cardinal symptom, Signs after the treatment.For 73 routine anal cryptitis patients, the clinical recovery rate of this suppository is 64.3%, and obvious effective rate is 15.7%, and effective percentage is 18.6%, and cure-remarkable-effectiveness rate is 98.6%; For 32 routine hemorrhoid patients, the clinical recovery rate of this suppository is 25.4%, and obvious effective rate is 44.8%, and effective percentage is 22.4%, and cure-remarkable-effectiveness rate is 92.5%.The curative effect of treatment I, II phase internal hemorrhoid and mixed hemorrhoid and present contrast medicine Moschus ZHICHUAN SHUAN there was no significant difference, but the curative effect of treatment anal cryptitis obviously is better than the Moschus ZHICHUAN SHUAN.Do not find in the therapeutic process that it has obvious damage to the heart, liver, renal function and blood system, clinical practice safety.
Composition principle of the present invention is: the Calculus Bovis in the side, and gas fragrance hardship, then sweet cold can clear away heart-fire, has one's ideas straightened out, eliminating phlegm, cool liver, endogenous wind stopping, eliminating fire and detoxication, eliminating stagnationization stagnate." the first hardship of distinguishing the flavor of is then sweet, goes into surgery oral medicine, can separate furunculosis, all poison of carbuncle furuncle, the pain relieving of being used as medicine, diffusing poison as refreshing as " book on Chinese herbal medicine is stated an ancient unit of weight "." and " Bencao Congxin " " sharp expectorant is cool frightened, sensible exorcising evil spirits for the sweet cold of Calculus Bovis, clearing away heart-fire detoxification." so the monarch drug in the Calculus Bovis side of being.Cortex Phellodendri, abnormal smells from the patient are all thick, and be cold in nature moist, property master sedimentation, and heat clearing and damp drying, furuncle is treated in detoxifcation.The heresy of relieving inflammation or internal heat is separated fire-toxin, subduing inflammation, tissue regeneration promoting meat, removing the necrotic tissue meat, it is wet to receive water, rush down damp and hot, for rushing down the key medicine of damp-heat in lower-JIAO clearly." herbal classic " " main the five internal organs the intestines and stomach stagnation of pathogenic heat, jaundice perianal abscess ", and " medicine justice " " the Cortex Phellodendri bitter in the mouth to the marrow, being enough to pathogenic fire reducing can be capit ad calcem ... brown, controls the red anal fistula of intestinal, seminal emission nebulousurine, jaundice due to damp-heat ".Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication, the cloudy matter of its body is dry, and is extremely cold to hardship, bitter to fall sun, cold to win heat, abnormal smells from the patient is all thick, directly rolls over the intensity of a fire, wash heat in blood, the dehumidifying fire is separated all furuncle fire-toxin, " book on Chinese herbal medicine justice " " Rhizoma Coptidis big bitter Great Cold, bitter dampness, cold prevailing over heat; it is damp and hot to rush down the intestines and stomach, can rush down and fall the wet fire that all are had a surplus ".Gold dollar is cured tame Lee Dong Yuan and is pointed out " all carbuncle furuncle infectionss all belong to heart-fire, all skin ulcers should with Rhizoma Coptidis "." not Lu " " Rhizoma Coptidis ... mainly let out out-of-the-wayly, the person of letting out is rushed down profit also, out-of-the-way person, the large intestine hematochezia also is commonly called as and is dysentery.Rhizoma Coptidis and Cortex Phellodendri help the Calculus Bovis heat-clearing and toxic substances removing altogether, and the curative effect of damp eliminating pathogenic fire purging for the ministerial drug in the side, is used charred Radix Et Rhizoma Rhei, and abnormal smells from the patient is deep, and it is descending to land vertically, eliminating fire and detoxication, and heat conduction is descending, and removing heat from blood swings dirt, gets it with the charcoal person and delays also, and have cooling blood and removing stasis, the effect of hemostasis eliminating fire and detoxication." medicine justice " " the Radix Et Rhizoma Rhei abnormal smells from the patient is deep to land vertically descendingly, walks and does not keep, and the power of forcing the way to of closing of cutting is arranged "." book on Chinese herbal medicine is highly necessary " " all diseases of penting up, the internal organs heavily fortified point is puckery, the dry and big constipation of rectum, carbuncle is just sent out, excessive noxious heat and big constipation ... must use bitter cold, can be also with Radix Et Rhizoma Rhei ".The Myrrha toil is flat, and can lead to and can loose, energy dissipating blood stasis blood, the stagnated blood that disappears, broken disease is long-pending, and qualcomm meridian is treated the carbuncle skin ulcer, granulation promoting meat, promoting the circulation of QI to relieve pain.The Li Gao cloud " Myrrha is being controlled the loose section of blood of skin ulcer, and this medicine pushes away Chen Zhixin, thus can break stagnated blood, reducing swelling and alleviating pain, for the strange medicine of persons particularly liable to develop skin infection also ", be adjuvant drug in the side.Gas virtue with Borneolum Syntheticum is strong, flavor Da Xin, and property is apt to away scurry, and logical all keys do not have toward not reaching, and the gas of fragrance can be warded off all evil poison, is messenger drug in the side.All medicine compatibilities are proper, and clearing heat and expelling damp is with thorough its source, make damp and hot that detoxicating is explained by oneself, the QI and blood smoothness, swelling and ache disappears and has blood in stool and end.This side forms rationally, and all medicines are that " Chinese pharmacopoeia is recorded, no eighteen incompatible medicaments, the incompatibility of nineteen medicaments of mutual restraint.
The specific embodiment
Now in conjunction with the embodiments enforcement of the present invention is described further:
Above Six-element raw material Chinese medicine is got Rhizoma Coptidis 200g, Cortex Phellodendri 350g, adds water (flooding medicine) and decocts each 2 hours three times, collecting decoction filters, and leaves standstill 24 hours, gets supernatant and is evaporated to the clear paste that relative density is 1.05~1.10 (70~80 ℃), spray drying is ground into fine powder, and is standby; Get Radix Et Rhizoma Rhei (charcoal) 100g and Myrrha (processed) 80g, baking (60 ℃) 30 minutes, sealing, cooling is ground into fine powder rapidly, and is standby; Other gets In vitro cultured Calculus Bovis 12g, Borneolum Syntheticum 15g, and pulverize separately becomes fine powder, and with above-mentioned fine powder mixing, other gets mixed fatty glycerides 1200~1250g, and heat fused (45~50 ℃) adds above-mentioned medicated powder, mixing, and moulding is made 1000, promptly.
Claims (3)
1. Chinese patent medicine for the treatment of anal cryptitis, hemorrhoid disease; it is characterized in that: it is that crude drug by following content is prepared from: In vitro cultured Calculus Bovis 11~13g; Cortex Phellodendri 300~400g; Rhizoma Coptidis 150~250g; Radix Et Rhizoma Rhei 50~150g; Myrrha 50~100g, Borneolum Syntheticum 10~20g, mixed fatty glycerides 1000~1500g.
2. by the described a kind of Chinese patent medicine for the treatment of anal cryptitis, hemorrhoid disease of claim 1; it is characterized in that: the concrete value of above-mentioned selected each crude drug is: In vitro cultured Calculus Bovis 12g; Cortex Phellodendri 350g; Rhizoma Coptidis 200g; Radix Et Rhizoma Rhei 100g, Myrrha 80g, Borneolum Syntheticum 15g; mixed fatty glycerides 1250g makes 1000 altogether.
3. by the described a kind of Chinese patent medicine for the treatment of anal cryptitis, hemorrhoid disease of claim 1, it is characterized in that: the character of above-mentioned Chinese patent medicine is the bullet-shaped suppository of sepia to black.
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CN200610019797A CN1907371B (en) | 2006-08-03 | 2006-08-03 | Chinese patent medicine for treating anus cryptitis and hemorrhoid |
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CN200610019797A CN1907371B (en) | 2006-08-03 | 2006-08-03 | Chinese patent medicine for treating anus cryptitis and hemorrhoid |
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CN1907371A CN1907371A (en) | 2007-02-07 |
CN1907371B true CN1907371B (en) | 2010-05-12 |
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CN103784569B (en) * | 2014-02-17 | 2016-03-23 | 大连圣弘医药有限公司 | A kind ofly treat Chinese medicine of hemorrhoid disease and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1258527A (en) * | 1998-12-30 | 2000-07-05 | 苑子毅 | Fast-acting piles-treating Chinese medicine preparation |
CN1365821A (en) * | 2001-11-12 | 2002-08-28 | 郑东阳 | Medicine 'Huwei Dan' for treating injury and gastroenteropathy |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1258527A (en) * | 1998-12-30 | 2000-07-05 | 苑子毅 | Fast-acting piles-treating Chinese medicine preparation |
CN1365821A (en) * | 2001-11-12 | 2002-08-28 | 郑东阳 | Medicine 'Huwei Dan' for treating injury and gastroenteropathy |
Non-Patent Citations (4)
Title |
---|
谭德福.中药保留灌肠疗法的临床应用.中医药学报 6.1999,(6),54-56. |
谭德福.中药保留灌肠疗法的临床应用.中医药学报 6.1999,(6),54-56. * |
马燕玲等.痔疮治疗药市场分析.上海医药24 8.2003,24(8),365-368. |
马燕玲等.痔疮治疗药市场分析.上海医药24 8.2003,24(8),365-368. * |
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