CN102726462B - Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method - Google Patents
Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method Download PDFInfo
- Publication number
- CN102726462B CN102726462B CN2012102128833A CN201210212883A CN102726462B CN 102726462 B CN102726462 B CN 102726462B CN 2012102128833 A CN2012102128833 A CN 2012102128833A CN 201210212883 A CN201210212883 A CN 201210212883A CN 102726462 B CN102726462 B CN 102726462B
- Authority
- CN
- China
- Prior art keywords
- agent
- strawberry
- mock
- herba duchesneae
- duchesneae indicae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000256113 Culicidae Species 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 241000196324 Embryophyta Species 0.000 title abstract description 17
- 244000084767 Potentilla indica Species 0.000 title abstract 5
- 239000003139 biocide Substances 0.000 title abstract 4
- 239000000284 extract Substances 0.000 claims abstract description 54
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000008187 granular material Substances 0.000 claims abstract description 19
- 239000000839 emulsion Substances 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 9
- 239000006185 dispersion Substances 0.000 claims abstract description 6
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 244000169544 Duchesnea indica Species 0.000 claims description 61
- 239000002994 raw material Substances 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 30
- 239000002270 dispersing agent Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- -1 aralkyl phenol Chemical compound 0.000 claims description 13
- 239000004530 micro-emulsion Substances 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 13
- 238000007689 inspection Methods 0.000 claims description 12
- 238000009736 wetting Methods 0.000 claims description 12
- 239000011230 binding agent Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000005469 granulation Methods 0.000 claims description 10
- 230000003179 granulation Effects 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 239000000080 wetting agent Substances 0.000 claims description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 6
- 239000007884 disintegrant Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 150000002170 ethers Chemical class 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- 239000000440 bentonite Substances 0.000 claims description 5
- 229910000278 bentonite Inorganic materials 0.000 claims description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical group O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 5
- 235000012054 meals Nutrition 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 229920005610 lignin Polymers 0.000 claims description 4
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 4
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 4
- VGCZCJQRGDELDD-UHFFFAOYSA-N 2,2-dioxo-1,3,2-dioxathiepane-4,7-dione Chemical compound O=C1CCC(=O)OS(=O)(=O)O1 VGCZCJQRGDELDD-UHFFFAOYSA-N 0.000 claims description 3
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 229920001732 Lignosulfonate Polymers 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 claims description 3
- 150000004996 alkyl benzenes Chemical class 0.000 claims description 3
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 3
- 229940077388 benzenesulfonate Drugs 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 239000007859 condensation product Substances 0.000 claims description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 239000010451 perlite Substances 0.000 claims description 3
- 235000019362 perlite Nutrition 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
- 235000011008 sodium phosphates Nutrition 0.000 claims description 3
- 239000004575 stone Substances 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 3
- 239000013638 trimer Substances 0.000 claims description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
- 239000010455 vermiculite Substances 0.000 claims description 3
- 229910052902 vermiculite Inorganic materials 0.000 claims description 3
- 235000019354 vermiculite Nutrition 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000010008 shearing Methods 0.000 claims description 2
- 238000002137 ultrasound extraction Methods 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 abstract description 6
- 241000255925 Diptera Species 0.000 abstract description 4
- 230000000857 drug effect Effects 0.000 abstract description 4
- 230000010429 evolutionary process Effects 0.000 abstract description 2
- 230000037353 metabolic pathway Effects 0.000 abstract description 2
- 239000003651 drinking water Substances 0.000 abstract 1
- 235000020188 drinking water Nutrition 0.000 abstract 1
- 239000012669 liquid formulation Substances 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 16
- 241000144210 Culex pipiens pallens Species 0.000 description 11
- 239000000469 ethanolic extract Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 231100000135 cytotoxicity Toxicity 0.000 description 4
- 230000003013 cytotoxicity Effects 0.000 description 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 241000405414 Rehmannia Species 0.000 description 2
- OXVUXGFZHDKYLS-BLIWDXROSA-N Tormentic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C OXVUXGFZHDKYLS-BLIWDXROSA-N 0.000 description 2
- QODJNKUPKGOPNE-UHFFFAOYSA-N [P].CC1=NC=CC=C1 Chemical compound [P].CC1=NC=CC=C1 QODJNKUPKGOPNE-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940074391 gallic acid Drugs 0.000 description 2
- 235000004515 gallic acid Nutrition 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 231100000225 lethality Toxicity 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- VULLSLYDWNGNKZ-UHFFFAOYSA-N 12319Tetrahydroxyurs-12-en-28-oic acid Natural products OC1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C VULLSLYDWNGNKZ-UHFFFAOYSA-N 0.000 description 1
- JXRYDOZRPYFBKO-UHFFFAOYSA-N 3,4-dimethoxy-cinnamic acidmethyl ester Natural products COC(=O)C=CC1=CC=C(OC)C(OC)=C1 JXRYDOZRPYFBKO-UHFFFAOYSA-N 0.000 description 1
- JFJWMFPFMLRLMI-UHFFFAOYSA-N 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylic acid Chemical compound O1C(=O)C2=CC(O)=C(O)C(O)=C2C2=C1C(=O)CC2C(=O)O JFJWMFPFMLRLMI-UHFFFAOYSA-N 0.000 description 1
- 241000256173 Aedes albopictus Species 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000561734 Celosia cristata Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000089742 Citrus aurantifolia Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241001516139 Disporum viridescens Species 0.000 description 1
- 241001146155 Emilia Species 0.000 description 1
- 235000019049 Emilia coccinea Nutrition 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- OXVUXGFZHDKYLS-UHFFFAOYSA-N Jacarandic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C OXVUXGFZHDKYLS-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- IYMHVUYNBVWXKH-ZITZVVOASA-N Pedunculagin Chemical compound C([C@H]1OC2O)OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)O[C@H]1[C@H]1[C@H]2OC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(O)C=C2C(=O)O1 IYMHVUYNBVWXKH-ZITZVVOASA-N 0.000 description 1
- HVXQPVRDPFKKHP-UHFFFAOYSA-N Pedunculagin Natural products OC1C2COC(=O)c3cc(O)c(O)c(O)c3c4c(O)c(O)c(O)cc4C(=O)OC(O2)C5OC(=O)c6cc(O)c(O)c(O)c6c7c(O)c(O)c(O)cc7C(=O)OC15 HVXQPVRDPFKKHP-UHFFFAOYSA-N 0.000 description 1
- 229920000158 Pedunculagin Polymers 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- MLKQAGPAYHTNQQ-BRDPIYJESA-N [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1r,2r,4as,6ar,6as,6br,8ar,10r,11r,12ar,14bs)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate Chemical compound O=C([C@]12CC[C@H]([C@@]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)(C)O)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O MLKQAGPAYHTNQQ-BRDPIYJESA-N 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- APOYITXPNFORST-UHFFFAOYSA-N brevifolin carboxylic acid Natural products OC1=C(O)C(O)=C2C(CC(C3=O)C(=O)O)=C3OC(=O)C2=C1 APOYITXPNFORST-UHFFFAOYSA-N 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006298 dechlorination reaction Methods 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- OCNYGKNIVPVPPX-HWKANZROSA-N methyl caffeate Chemical compound COC(=O)\C=C\C1=CC=C(O)C(O)=C1 OCNYGKNIVPVPPX-HWKANZROSA-N 0.000 description 1
- IYMHVUYNBVWXKH-UHFFFAOYSA-N pedunculagin I isomer Natural products OC1OC2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C2C1OC(=O)C1=CC(O)=C(O)C(O)=C1C1=C(O)C(O)=C(O)C=C1C(=O)O2 IYMHVUYNBVWXKH-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- QGTBWTXRSOKBBE-QZIYNGKJSA-N rosamultin Natural products CC1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2CC=C4[C@@H]5[C@@](C)(O)C(C)(C)CC[C@@]5(CC[C@@]34C)C(=O)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O QGTBWTXRSOKBBE-QZIYNGKJSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical compound C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- MLKQAGPAYHTNQQ-UHFFFAOYSA-N tormentic acid glucosyl ester Natural products C1CC(C2(CCC3C(C)(C)C(O)C(O)CC3(C)C2CC=2)C)(C)C=2C2C(O)(C)C(C)CCC21C(=O)OC1OC(CO)C(O)C(O)C1O MLKQAGPAYHTNQQ-UHFFFAOYSA-N 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a Duchesnea indica Focke-containing plant source mosquito larvae killing agent, the prepared plant source mosquito larvae killing agent is prepared by taking Duchesnea indica stem leaf fine powder or a Duchesnea indica extract as a main component and adding an auxiliary agent, the preparation form can be a soluble liquid formulation, a wettable powder, a water dispersion granule, a particulate agent, a micron emulsion or an emulsion in water. According to the invention, the Duchesnea indica Focke-containing plant source mosquito larvae killing agent has substantial drug effect, an active compound is a naturally existed substance, the inherent energy and circulated and metabolic pathway of substances during a long evolutionary process can be formed, no residue is existed after application, biological enrichment can not be generated; the agent is relatively safe to a non target biophase; and the present invention is not easy to generate pesticide resistance. The agent of the invention is suitable for sensitive areas of indoor and outdoor mosquito places, drinking water treatment and the like.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to agricultural chemicals preparation and manufacture field, particularly a kind ofly utilize the plant mock-strawberry to kill mosquito larvae agent and method thereof for prepared by raw material.
Background technology
Mock-strawberry (Duchesnea indica Focke.) is rose family mock-strawberry platymiscium, call three wind, cockscomb fruit, the certain kind of berries, tassel flower, five-fingered jack, Disporum viridescens (Maxim.) Nakai-D. A Grag var Maxim etc.Mock-strawberry is herbaceos perennial, overgrows, and takes root on joint, and rhizome is short, sturdy; Trifoliolate leaf, have tooth, opens chrysanthemum, and the hypocarp cerise is expanded if covered basin.
The mock-strawberry herb all can be used as medicine, and has the effect of heat-clearing, cool blood, detumescence, removing toxic substances, multiplex, snake bite and insect sting swollen in the frightened epilepsy for the treatment of pyreticosis, abscess of throat, cough haematemesis, furunculosis carbuncle, eczema, dysentery and burn and scald etc.Pharmacological research shows in addition, and that mock-strawberry has is anticancer, antibacterial, strengthen immune effect, and cardiovascular, smooth muscle, central nervous system, internal secretion are also had certain effect.
The mock-strawberry adaptive faculty is strong, except high and cold, arid Desert Area, at south China, northern wide geographic area, distribution is arranged.Under field conditions (factors), wild in hillside, roadside, limes marginis, ridge etc. locate, and grows fine, and often forms large stretch of surging group.
The extraction that the at present research of mock-strawberry mainly concentrates on its chemical composition with separate, the mock-strawberry chemical composition of open report be take phenolic acid and phenol esters of gallic acid, triterpenes as main, phenolic compound mainly contains gallic acid, methyl caffeate, protocatechuic acid, Pedunculagin, brevifolin carboxylic acid, and triterpene compound mainly be take ursolic acid, tormentic acid, rosamultin etc. as main.Contain in addition kaemferitrin---a unique flavonoids.According to the data-searching that the applicant does, the bright rare report of the application of Herba Duchesneae Indicae extract on agricultural chemicals.
Summary of the invention
The object of the invention is to, provide a kind of and utilize the plant mock-strawberry to kill mosquito larvae agent and method thereof for prepared by raw material, do not contain any chemical pesticide composition, to the people, animal low toxicity, after using, insect is difficult for developing immunity to drugs.
For realizing above-mentioned task, the technical scheme that the present invention takes is:
A kind of plant resource that contains mock-strawberry active ingredient kills the mosquito larvae agent, it is characterized in that, this making kills the mosquito larvae agent to be main component by Herba Duchesneae Indicae extract and to add auxiliary agent formulated, and the preparation form is soluble liquid or granule, wherein:
Described soluble liquid is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%.
Described wetting powder is prepared by following raw materials by weight:
Mock-strawberry cauline leaf fine powder: 40%～60%, wetting agent: 1%～5%, dispersant: 5～15%, surplus is filler, the percentage by weight sum of raw material is 100%.
Described water dispersible granules is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5～10%, binding agent: 1%～5%, all the other are carrier, the percentage by weight sum of raw material is 100%.
Described granule is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 5%～20%, dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%.
Described microemulsion is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, solvent 40～84%, surfactant 1%～20%, the summation of raw material is 100%.
Described aqueous emulsion is following raw materials by weight preparation again:
Herba Duchesneae Indicae extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2～1%; Surplus is water, and the percentage by weight sum of raw material is 100%.
Described Herba Duchesneae Indicae extract is that the stem of mock-strawberry, leaf are pulverized, and uses industrial alcohol extract, and extract obtains through concentrated.
Described emulsifier is one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers and similar substance, castor oil and oxirane;
Described organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide or solvent well known in the art;
Described wetting agent is one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Described dispersant is one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, lignin and derivative sulfonate thereof, carboxymethyl cellulose;
Described disintegrant is one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Described binding agent is bentonite and imvite;
Described filler or carrier are that talcum powder, white carbon, diatomite, bentonite, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite.
Described surfactant is one or more mixture of this area all kinds of surface reactive materials commonly used.
Described antifreezing agent is ethylene glycol or propane diols;
Described thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate.
The above-mentioned plant resource that contains Herba Duchesneae Indicae extract kills the mosquito larvae agent and it is characterized in that, carries out according to the following steps:
A, dry mock-strawberry stem, leaf are pulverized, crossed 40 mesh sieves;
B, with 3～4 times of industrial alcohols to mock-strawberry crushed material quality, be solvent, at 50～60 ℃ of ultrasonic extraction 1h;
C, by the method for Vacuum Concentration, mock-strawberry is got to the thing leaf and is concentrated into the mock-strawberry raw meal and minces and wait weight, obtain Herba Duchesneae Indicae extract;
D, in the preparation still, according to proportional quantity, by Herba Duchesneae Indicae extract, emulsifier, solvent, in the preparation still, stir transparently, through quality inspection, namely obtain soluble liquid;
E, the meal of steps A gained is minced and pulverizes with the high-energy crushing machine, cross 325 mesh sieves, and guarantee that the crushed material more than 95% passes through 325 mesh sieves, the fine powder after pulverizing and filler, insecticides adjuvant are namely made wetting powder after according to the wetting powder proportional quantity, fully mixing;
F, mix according to proportional quantity, after stirring, obtain the order powder through pulverizing, the order powder is mixed with binding agent, then granulation, oven dry, screening, pass through quality inspection and namely obtain water dispersion granule.
G, in the absorption mixer, according to the granule proportional quantity, Herba Duchesneae Indicae extract, dispersant binding agent are mixed, after quality inspection, i.e. granulation agent.
H, in reactor, according to the microemulsion proportional quantity, Herba Duchesneae Indicae extract, organic solvent, surfactant, antifreezing agent and water are mixed, in reactor, stir transparently, through quality inspection, namely obtain microemulsion;
I, according to proportional quantity, Herba Duchesneae Indicae extract, organic solvent, surfactant, antifreezing agent, thickener and water are mixed, emulsion dispersion under the effect of high-speed shearing machine, after quality inspection, namely make aqueous emulsion.
It is a kind of novel mosquito larvae agent of killing that the plant resource that contains mock-strawberry active ingredient of the present invention kills the mosquito larvae agent, and culex pipiens pallens larvae is had to control efficiency preferably, is the desirable nuisanceless mosquito larvae agent of killing.
The invention has the advantages that:
1, mock-strawberry is natural active matter, derives from nature, in long-term evolutionary process, has formed intrinsic energy and material recycle metabolic pathway, so use rear noresidue, can not cause biological concentration; Easily degraded in environment, to mammal low toxicities such as people and animals, to pest natural enemy and other beneficial organism safety.
2, the formulation adopted is mainly soluble liquid, granule etc., without aromatic hydrocarbon solvents such as dimethylbenzene, greatly reduces the destruction to environment, has reduced in the dispenser process murder by poisoning to operator.
3, the mechanism of action of insect is different to conventional pesticide, insect is difficult for developing immunity to drugs.
Embodiment
The applicant is on the basis of 96 Plants being killed to the active extensively screening of mosquito larvae, and that finds mock-strawberry kills the mosquito larvae activity, and its extract shows higher cytotoxicity to culex pipiens pallens larvae.The applicant is main component and adds auxiliary agent formulated mock-strawberry cauline leaf fine powder or Herba Duchesneae Indicae extract, and the preparation form is soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion; Wherein:
Described soluble liquid is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%;
Described wetting powder is prepared by following raw materials by weight:
Mock-strawberry cauline leaf fine powder: 40%～60%, wetting agent: 1%～5%, dispersant: 5%～15%, surplus is filler, the percentage by weight sum of raw material is 100%;
Described water dispersible granules is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described granule is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 5%～20%; Dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described microemulsion is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, solvent: 40%～84%, surfactant 1%～20%, the summation of raw material is 100%;
Described aqueous emulsion is following raw materials by weight preparation again:
Herba Duchesneae Indicae extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2～1%; Surplus is water, and the percentage by weight sum of raw material is 100%.
For a more clear understanding of the present invention and the drug effect of medicament of the present invention, below the specific embodiment completed according to technical solution of the present invention that provides by the inventor the present invention is described in further detail, these are only the present invention embodiment preferably, but are not limited to these embodiment.
It should be noted that, in following embodiment, it is raw material that Herba Duchesneae Indicae extract adopts mock-strawberry stem, leaf, uses industrial alcohol extract, and extract obtains through concentrated.
Emulsifier can be one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers and similar substance, castor oil and oxirane;
Organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide or solvent well known in the art;
Wetting agent can be one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Dispersant can be one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, lignin and derivative sulfonate thereof, carboxymethyl cellulose;
Disintegrant can be one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Binding agent can be bentonite and imvite; Filler or carrier can be that common brick, clay, slag kaolin, diatomite, white carbon, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite;
Surfactant is one or more mixture of this area all kinds of surface reactive materials commonly used.
Described antifreezing agent is ethylene glycol or propane diols;
Described thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate.
Embodiment 1: contain the preparation that Herba Duchesneae Indicae extract kills mosquito larvae wettable liquor
Take Herba Duchesneae Indicae extract 20kg, polyoxyethylene nonylphenol ether phosphate 15kg, ethanol 65kg add in the preparation still, are stirred well to transparently, get final product to such an extent that contain the soluble liquid 100kg of 20% mock-strawberry.
Embodiment 2: contain the preparation that Herba Duchesneae Indicae extract kills the mosquito larvae wetting powder
Take mock-strawberry meal 55kg, be crushed to 95% and cross 325 mesh sieves, after this tissue fine powder is fully mixed with 20kg White Carbon black, 15kg sodium lignin sulfonate, 10kg dispersant NNO, get final product to such an extent that contain 55% mock-strawberry wettable insecticidal dust 100kg.
Embodiment 3: contain the preparation that Herba Duchesneae Indicae extract kills the mosquito larvae water dispersible granules
Take Herba Duchesneae Indicae extract 20kg, after adding 15kg wetting agent, 10kg lignin, 5kg sodium pyrophosphate, 48kg diatomite to stir, through pulverizing, obtain the order powder, the order powder is mixed with the 2kg imvite, then granulation, oven dry, screening, namely obtain and contain 20% mock-strawberry water dispersion granule 100kg through quality inspection.
Embodiment 4: contain the preparation that Herba Duchesneae Indicae extract kills the mosquito larvae granule
Take Herba Duchesneae Indicae extract 15Kg, add 15Kg Dispersant MF, 5Kg dispersant ME, 65Kg slag kaolin to mix, then granulation, oven dry, screening, namely obtain and contain 15% mock-strawberry granule 100Kg through quality inspection.
Embodiment 5: contain the preparation that Herba Duchesneae Indicae extract kills the mosquito larvae microemulsion
Take Herba Duchesneae Indicae extract 25kg and 20kg polyoxyethylene nonylphenol ether phosphate, be dissolved in 5kg methyl alcohol, above solution is heated to 40 ℃ in homogenizer, under high-speed stirred, add deionized water 50kg; Dropwise, then stir 45min, cooling, must contain the microemulsion 100kg of 25% mock-strawberry.
Embodiment 6: contain the preparation that Herba Duchesneae Indicae extract kills the mosquito larvae aqueous emulsion
Take Herba Duchesneae Indicae extract 25kg, dissolve with methyl alcohol 5kg, under agitation add polyoxyethylene nonylphenol ether phosphate 20kg, stir, add deionized water 50kg, get final product to such an extent that contain 25% mock-strawberry aqueous emulsion 100kg.
In above-mentioned Preparation Example, the consumption of mock-strawberry cauline leaf fine powder or Herba Duchesneae Indicae extract has only been selected a kind of, be used to testing investigation.Certainly, in the making for preparing soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion, in the scope that the present invention requires, all can access qualified preparation.
EXPERIMENTAL EXAMPLE 1: the toxicity of mock-strawberry ethanol extract Culex pipiens pallens 3 instar larvaes is measured
1.1 materials and methods
1.1.1 examination worm
Culex pipiens pallens Culex pipiens pallens, Nuisanceless Pesticide Research Service Center, Xibei Agroforestry Science and T's cultivation.
1.1.2 reagent agent
The mock-strawberry ethanol extract, extracted and obtain from mock-strawberry by Nuisanceless Pesticide Research Service Center, Xibei Agroforestry Science and T.
1.2 give birth to the survey method
The immersion method of WHO recommendation is adopted in this experiment to the mensuration of culex pipiens pallens larvae toxic action.Concrete operations are as follows: during mensuration, get the mock-strawberry ethanol extract and spend the liquid that chlorine water is diluted to certain multiple.In the 100ml beaker, add respectively 25ml dechlorination air water, then introduce 15 in the same sizes, health, strong Culex pipiens pallens 3 instar larvaes, last taking liquid 25ml joins in small beaker.Be placed in (26 ± 1) ℃, humidity (70 ± 10) %, illumination 12:12(L:D) under condition, respectively at 6h, 24h check result, calculate lethality and corrected mortality.The vibration beaker, and touch the examination worm with blunt-ended forceps, if the examination worm is motionless, namely be judged to death.Each sample triplicate, make solvent control with the ethanol of respective volume mark, and make blank with clear water at every turn.
1.3 results and analysis
Adopt immersion method, system measurement the cytotoxicity of mock-strawberry ethanol extract to Culex pipiens pallens 3 instar larvaes, added up the lethality of 6h, 24h, and tried to achieve the virulence curve, the results are shown in Table 1 and table 2.
Table 1: the toxic effect of mock-strawberry ethanol extract to Culex pipiens pallens 3 instar larvaes
Table 2: the mock-strawberry ethanol extract is to culex pipiens pallens larvae 24h Toxicity Determination result
| The medicament title | Virulence regression equation (Y=) | LC 50(mg/L) | Correlation coefficient r | Chi-square value X 2 |
| The mock-strawberry ethanol extract | 1.2675+2.7331X | 23.21 | 0.8988 | 3.19 |
As can be known by above-mentioned two tables, mock-strawberry has cytotoxicity preferably to culex pipiens pallens larvae.
EXPERIMENTAL EXAMPLE 2: contain the thing source that Herba Duchesneae Indicae extract plants and kill mosquito larvae agent kill mosquito larva field trial
For the drug effect situation that mosquito larvae agent kill mosquito larva is killed in clear and definite six Plants sources, the applicant carried out the test of on-the-spot kill mosquito larva effect to this medicament in Yang Ling demonstration area, Shaanxi Province in 2011.
1.1 examination worm
The Culex pipiens pallens Culex pipiens pallens grown under the natural conditions of Yang Ling area, aedes albopictus Aedes albopictus.
1.2 reagent agent
Contain 30% mock-strawberry soluble liquid, medicament code name SM1;
Contain 60% mock-strawberry wetting powder, medicament code name SM2;
Contain 25% mock-strawberry water dispersible granules, medicament code name SM3;
Contain 20% mock-strawberry granule, medicament code name SM4;
Contain 25% mock-strawberry microemulsion, medicament code name SM5;
Contain 25% mock-strawberry aqueous emulsion, medicament code name SM6;
1% Swebate granule, medicament code name 007, produced by BASF China;
20% methylpyridine phosphorus aqueous emulsion, medicament code name 008, profit chemical science and technology company produces by the yiyang, hunan sea.
1.3 test method
Get 40 Plastic Drums (bore 28cm, footpath, end 25cm, high 35cm), be used separately as experimental group (n=4) and control group (n=4).Bucket is placed on outdoor bosky meadow, in each barrel, puts into the sewage 10L(depth of water of being fetched by the evil dried rhizome of rehmannia and be about 20cm, surface area is about 0.055m
2), approximately 150 of mosquito larvaes, test after adaptation 1d.Use respectively SM1, SM2, SM3, SM4, SM5, SM6(are 1.0g/m by active ingredient
3), 007(is 0.5g/m by active ingredient
3), 008(is by active ingredient 0.8g/m
3).And to experimental group, each barrel of control group, added respectively 50 of the mosquito larvaes of catching back from the evil dried rhizome of rehmannia in the 12nd day, the 26th day after on-test.
1.4 density survey method
Use the special-purpose bailer (capacity is about 200ml) of investigation mosquito larvae density, along the barrel edge water surface, choose mosquito larvae density higher part position and bail once, the counting mosquito larvae.Before dispenser after 1d and dispenser the 1st, 7,14,21,28 and 35d respectively investigate 1 time, investigate altogether 7 times.
1.5 result is calculated
1.6 results and analysis
Adopt the Plastic Drum method to measure the test of 8 kinds of different medicaments to mosquito larvae poisoning drug effect, the results are shown in Table 3.As shown in Table 3, at 1.0g/m
3Under dosage, the plant resource that contains mock-strawberry kills the mosquito larvae agent after processing one day, and mosquito larvae density descends all over 90%, the rate of descent still had over 80% in the 28th day after processing.Simultaneously, in 28 days after processing, 6 kinds of preparing of the present embodiment contain RPI that the plant resource of mock-strawberry kills the mosquito larvae agent all lower than 50, illustrate mosquito larvae is had to control efficiency preferably.In addition, whole control efficiency and chemistry commonly used that the mosquito larvae agent is killed in this 6 Plants source kill the standby granule of mosquito larvae agent 007(1% peace) close, be better than 008(20% methylpyridine phosphorus aqueous emulsion).
The different medicaments of table 3:8 kind are to mosquito larvae cytotoxicity result
The plant resource that 6 kinds of preparing of above-described embodiment contain mock-strawberry kills during the mosquito larvae agent tests at the scene, quick-acting is preferably not only arranged, also to kill the mosquito larvae agent suitable with chemistry for lasting effect, and to non-target organism and environmental friendliness, therefore very applicable in water source processing, gardens water body facility and family daily life, have very large application and popularization value.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can to some corrections of do or improvement, this will be apparent to those skilled in the art.Therefore, these corrections or the improvement done without departing from theon the basis of the spirit of the present invention, all belong to protection scope of the present invention.
Claims (3)
1. a plant resource that contains mock-strawberry active ingredient kills the mosquito larvae agent, it is characterized in that, this plant resource made kills the mosquito larvae agent to be main component by mock-strawberry cauline leaf fine powder or Herba Duchesneae Indicae extract and to add auxiliary agent formulated, and the preparation form is soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion; Wherein:
Described soluble liquid is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%;
Described wetting powder is prepared by following raw materials by weight:
Mock-strawberry cauline leaf fine powder: 40%～60%, wetting agent: 1%～5%, dispersant: 5%～15%, surplus is filler, the percentage by weight sum of raw material is 100%;
Described water dispersible granules is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described granule is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 5%～20%; Dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described microemulsion is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～30%, solvent: 40%～84%, surfactant 1%～20%, the summation of raw material is 100%;
Described aqueous emulsion is prepared by following raw materials by weight:
Herba Duchesneae Indicae extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2～1%; Surplus is water, and the percentage by weight sum of raw material is 100%;
It is raw material that described Herba Duchesneae Indicae extract adopts stem, the leaf of mock-strawberry, uses industrial alcohol extract, and extract obtains through concentrated.
2. the plant resource that contains mock-strawberry active ingredient as claimed in claim 1 kills the mosquito larvae agent, it is characterized in that:
Described emulsifier is one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers and similar substance, castor oil and oxirane;
Described organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide or solvent well known in the art;
Described wetting agent is one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Described dispersant is one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, lignin and derivative sulfonate thereof, carboxymethyl cellulose;
Described disintegrant is one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Described binding agent is bentonite and imvite;
Described filler or carrier are that talcum powder, white carbon, diatomite, bentonite, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite;
Described surfactant is one or more mixture of this area all kinds of surface reactive materials commonly used;
Described antifreezing agent is ethylene glycol or propane diols;
Described thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate.
3. the plant resource that contains mock-strawberry active ingredient claimed in claim 1 kills the preparation method of mosquito larvae agent, it is characterized in that, carries out according to the following steps:
A, dry mock-strawberry stem, leaf are pulverized, crossed 40 mesh sieves;
B, with 3～4 times of industrial alcohols to mock-strawberry crushed material quality, be solvent, at 50～60 ℃ of ultrasonic extraction 1h;
C, by the method for Vacuum Concentration, mock-strawberry is got to the thing leaf and is concentrated into the mock-strawberry raw meal and minces and wait weight, obtain Herba Duchesneae Indicae extract;
D, in the preparation still, according to proportional quantity, by Herba Duchesneae Indicae extract, emulsifier, solvent, in the preparation still, stir transparently, through quality inspection, namely obtain soluble liquid;
E, the meal of steps A gained is minced and pulverizes with the high-energy crushing machine, cross 325 mesh sieves, and guarantee that the crushed material more than 95% passes through 325 mesh sieves, the fine powder after pulverizing and filler, insecticides adjuvant are namely made wetting powder after according to the wetting powder proportional quantity, fully mixing;
F, mix according to proportional quantity, after stirring, obtain the order powder through pulverizing, the order powder is mixed with binding agent, then granulation, oven dry, screening, pass through quality inspection and namely obtain water dispersion granule;
G, in the absorption mixer, according to the granule proportional quantity, Herba Duchesneae Indicae extract, dispersant binding agent are mixed, then granulation, oven dry, screening, after quality inspection, i.e. granulation agent;
H, in reactor, according to the microemulsion proportional quantity, Herba Duchesneae Indicae extract, organic solvent, surfactant, antifreezing agent and water are mixed, in reactor, stir transparently, through quality inspection, namely obtain microemulsion;
I, according to proportional quantity, Herba Duchesneae Indicae extract, organic solvent, surfactant, antifreezing agent, thickener and water are mixed, emulsion dispersion under the effect of high-speed shearing machine, after quality inspection, namely make aqueous emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102128833A CN102726462B (en) | 2012-06-22 | 2012-06-22 | Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102128833A CN102726462B (en) | 2012-06-22 | 2012-06-22 | Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102726462A CN102726462A (en) | 2012-10-17 |
| CN102726462B true CN102726462B (en) | 2013-11-27 |
Family
ID=46983341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102128833A Expired - Fee Related CN102726462B (en) | 2012-06-22 | 2012-06-22 | Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102726462B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105767040A (en) * | 2016-04-08 | 2016-07-20 | 常州润达科技信息咨询有限公司 | Botanical pesticide for lepidoptera pests |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101559A (en) * | 1993-10-14 | 1995-04-19 | 刘彦彬 | Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method |
| CN1504216A (en) * | 2002-11-29 | 2004-06-16 | 贵阳新天药业股份有限公司 | Compound formulation of traditional Chinese medicine for assistant treatment of tumour and preparation method thereof |
| CN101486771A (en) * | 2009-02-27 | 2009-07-22 | 中国药科大学 | Duchesnea polysaccharide, as well as preparation and use thereof |
-
2012
- 2012-06-22 CN CN2012102128833A patent/CN102726462B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101559A (en) * | 1993-10-14 | 1995-04-19 | 刘彦彬 | Traditional Chinese medicine oral administration liquid for anti-cancer and its preparing method |
| CN1504216A (en) * | 2002-11-29 | 2004-06-16 | 贵阳新天药业股份有限公司 | Compound formulation of traditional Chinese medicine for assistant treatment of tumour and preparation method thereof |
| CN101486771A (en) * | 2009-02-27 | 2009-07-22 | 中国药科大学 | Duchesnea polysaccharide, as well as preparation and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102726462A (en) | 2012-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102613257B (en) | Lycoris radiata bulb extractive pesticide and method for preparing extractive | |
| CN103636660A (en) | Environmental-friendly particulate agent for controlling sugarcane pests | |
| CN101731288B (en) | Natural biological composition for preventing and treating agricultural pests and preparation method thereof | |
| CN103609597A (en) | Botanical synergistic compound pesticide | |
| CN103518729A (en) | Insecticidal acaricidal composition and application thereof | |
| CN104082300B (en) | Insecticide acaricide composition containing pyriproxyfen and spirodiclofen | |
| CN101485329B (en) | Agricultural chemical composition for disinsection and use thereof | |
| CN102726462B (en) | Duchesnea indica Focke-containing plant source mosquito larvae killing agent and its preparation method | |
| CN102228044B (en) | Insecticidal composition containing sufluoxime | |
| CN104381294B (en) | A kind of insecticide acaricide composition containing sulfur-phosphor and Envidor | |
| CN103651506B (en) | A kind of Pesticidal combination containing penta pyrrole worm guanidine and nimbin | |
| CN103651507B (en) | A kind of Pesticidal combination containing cycolxylidin and nimbin | |
| CN104286010B (en) | Composition pesticide containing sulfur-phosphor and Bifenazate | |
| CN102726456B (en) | Botanical mosquito larva killing agent containing effective components of Carduus crispus L., and its preparation method | |
| CN102524271A (en) | Cytisine and matrine insecticide water emulsion | |
| CN107593778A (en) | Plant source mosquitocidal children's agent of the curved colored corydalis containing the Qinling Mountains | |
| CN102057942B (en) | Emamectin benzoate and kadethrine compound insecticide | |
| CN105494450B (en) | Strong degradable natural pyrethrin emulsion of a kind of stability and preparation method thereof | |
| CN104255751A (en) | Mite-killing composition containing etoxazole and vermectin | |
| CN104082322B (en) | A kind of containing Nylar with the insecticide acaricide composition of Bifenazate | |
| CN102273489B (en) | Macleaya microcarpa emulsion for preventing and treating black peach aphid and red spider and preparation method thereof | |
| CN103109846B (en) | Dichlorovos kadethrine compounded pesticide | |
| CN102342305B (en) | Spurge oil emulsion for preventing spider mites of melon and vegetable crops and preparation method thereof | |
| CN105613562B (en) | A kind of agricultural pesticide composition and application thereof containing sulphur insect amide and dinotefuran | |
| CN106857696B (en) | A kind of Pesticidal combination and application thereof containing bitter pueraria root extract and sanguinarine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210125 Address after: 712100 Shaanxi Province, Xi'an city Yangling District Tai Road No. 3 demonstration Patentee after: NORTHWEST A & F University Address before: 712100 Shaanxi Province, Xi'an city Yangling District Tai Road No. 3 demonstration Patentee before: RESEARCH & DEVELOPMENT CENTER OF BIORATIONAL PESTICIDE YANGLING NONGKEDA |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131127 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |