CN102726456B - Botanical mosquito larva killing agent containing effective components of Carduus crispus L., and its preparation method - Google Patents
Botanical mosquito larva killing agent containing effective components of Carduus crispus L., and its preparation method Download PDFInfo
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Abstract
The invention discloses a botanical mosquito larva killing agent containing effective components of Carduus crispus L.. The prepared botanical mosquito larva killing agent containing the effective components of Carduus crispus L. is prepared through treating fine Carduus crispus L. strain powder or Carduus crispus L. extractsas a main effective component and adding assistants, and can be a soluble liquid, a wettable pulvis, a water dispersible granule, a particulate agent, a microemulsion or an emulsion in water. The botanical mosquito larva killing agent has the advantages of substantial larva killing effect, low toxicity, low residual, difficult generation of pests' resistances to the larva killing agent, simple preparation technology, and low cost, accords with present pesticide development trends, and can be applied to indoor and outdoor mosquito growth places, and sensitive areas such as drinking water processing areas and the like.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to agricultural chemicals preparation and manufacture field, particularly a kind of plant welted thistle that utilizes kills mosquito larvae agent and method thereof for prepared by raw material.
Background technology
Welted thistle (Carduus crispus L.) is composite family bristlethistle plant, calls old ox file, king etc. energetically.Welted thistle is 2 years living thorniness herbaceous plant, and the main root plumpness, stretch or deflection.Stem is upright, and tool is indulged rib, and rib has the green triangle thorn dentation wing intermittently.Single leaf alternate, stockless, embrace stem, bottom elliptic leaf shape lanceolar, pinniform drastic crack, edge spinosity usually.Xia Qiu is bloomed, capitulum, and involucre is bell, and flower is tubular flower, aubergine, the achene oblong, pappus white or canescence, be setiform.
Welted thistle herb or root are used as medicine.The flat bitter of its property, tool dispels the wind, the effect of the loose stasis of blood of dredging collateral, dampness removing, cool breeze, as long as be used for the treatment of anemopyretic cold, a wind is dizzy, the wind-heat paralysis, the skin profit is itched, urinary tract infections, chyluria, under the hematuria band, fall that to beat the stasis of blood swollen, burn and scald etc.At present, the screening of the step-down of bristlethistle plant, anti-inflammatory, anticancer component and research are in development, have a extensive future.
The welted thistle plant is widely distributed, and stock number is abundanter, because its breeding is fast, the vigorous weeds that sometimes become grow.Under field conditions (factors), wild in hillside, roadside, limes marginis, ridge etc. locate.
The extraction that at present mainly concentrates on its chemical composition for the research of welted thistle with separate, according to open report, it by welted thistle, is 95% alcohol extract with mass percent, in extract, separated β-amyrin palmitate, taraxol acetic acid esters, Luteolin, 30 carbonic acid, cupreol, stigmasterol, and from welted thistle, separating and obtain 5 novel isoquinoline alkaloids.According to the data-searching that the applicant does, the ethanol extract of welted thistle cauline leaf is withered to cucumber, miliary damping-off, tomato wheel line bacteriostasis are all stronger, and bibliographical information is not yet arranged in mosquito control.
Summary of the invention
The object of the invention is to, provide a kind of plant welted thistle that utilizes to kill mosquito larvae agent and method thereof for prepared by raw material, the prepared mosquito larvae agent of killing does not contain any chemical pesticide composition, and to the people, animal low toxicity, after using, insect is difficult for developing immunity to drugs.
For realizing above-mentioned task, the technical solution that the present invention takes is:
A kind of plant resource that contains welted thistle active ingredient kills the mosquito larvae agent, it is characterized in that, this making kills the mosquito larvae agent and is main active ingredient and added auxiliary agent formulated by welted thistle extract or welted thistle complete stool fine powder, the preparation form is soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion, wherein:
Described soluble liquid is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%.
Described wetting powder is prepared by following raw materials by weight:
Welted thistle complete stool fine powder: 40%～60%, wetting agent: 1%～5%, dispersant: 5%～15%, surplus is filler, the percentage by weight sum of raw material is 100%.
Described water dispersible granules is prepared by following raw materials by weight:
The welted thistle extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%.
Described granule is prepared by following raw materials by weight:
Welted thistle extract: 5%～20%; Dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%.
Described microemulsion is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, solvent 40～84%, surfactant 1%～20%, the summation of raw material is 100%.
Described aqueous emulsion is following raw materials by weight preparation again:
The welted thistle extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2%～1%; Surplus is water, and the percentage by weight sum of raw material is 100%.
Described emulsifier is one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers and similar substance, castor oil and oxirane;
Described organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide or solvent well known in the art;
Described wetting agent is one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Described dispersant is one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, lignin and derivative sulfonate thereof, carboxymethyl cellulose;
Described disintegrant is one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Described binding agent is bentonite and imvite;
Described filler or carrier are that common brick, clay, slag kaolin, diatomite, white carbon, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite.
Described surfactant is one or more mixture of this area all kinds of surface reactive materials commonly used.
Described antifreezing agent is ethylene glycol or propane diols;
Described thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate.
The above-mentioned plant resource that contains welted thistle active ingredient kills the mosquito larvae agent, it is characterized in that, carries out according to the following steps:
A, dry welted thistle plant is pulverized, cross 40 mesh sieves;
B, be solvent with 3～4 times of industrial alcohols to welted thistle crushed material quality, ultrasonic extraction 1h under 50 ℃～60 ℃ conditions;
The method of C, use Vacuum Concentration, be concentrated into the welted thistle extract and the weight such as the welted thistle raw meal minces, and obtains the welted thistle extract;
D, in the preparation still, according to proportional quantity, by welted thistle extract, emulsifier, solvent, in the preparation still, stir transparently, through quality inspection, namely obtain soluble liquid;
E, the meal of steps A gained is minced and pulverizes with the high-energy crushing machine, cross 325 mesh sieves, and guarantee that the crushed material more than 95% passes through 325 mesh sieves, the fine powder after pulverizing and filler, insecticides adjuvant are namely made wetting powder after according to the wetting powder proportional quantity, fully mixing;
F, mix according to proportional quantity, after stirring, obtain the order powder through pulverizing, the order powder is mixed with binding agent, then granulation, oven dry, screening, pass through quality inspection and namely obtain water dispersion granule.
G, in the absorption mixer, according to the granule proportional quantity, welted thistle extract, dispersant binding agent are mixed, after quality inspection, i.e. granulation agent.
H, in reactor, according to the microemulsion proportional quantity, welted thistle extract, organic solvent, surfactant, antifreezing agent and water are mixed, in reactor, stir transparently, through quality inspection, namely obtain microemulsion;
I, according to proportional quantity, welted thistle extract, organic solvent, surfactant, antifreezing agent, thickener and water are mixed, emulsion dispersion under the effect of high-speed shearing machine, after quality inspection, namely make aqueous emulsion.
It is a kind of novel mosquito larvae agent of killing that the plant resource that contains the welted thistle extract of the present invention kills the mosquito larvae agent, and culex pipiens pallens larvae is had to control efficiency preferably, is the desirable nuisanceless mosquito larvae agent of killing.
The invention has the advantages that:
1, welted thistle is natural active matter, in long-term evolutionary process, has formed intrinsic energy and material recycle metabolic pathway, therefore, easily degraded in environment, noresidue, to mammal low toxicities such as people, animal, have no side effect to the other biological in water body.
2, the formulation adopted is mainly soluble liquid, wetting powder, water dispersible granules or granule, has reduced the use of organic solvent, has reduced dust pollution, greatly reduces the destruction to environment, has reduced in the dispenser process murder by poisoning to operator.
3, the mechanism of action of insect is different to conventional pesticide, after using, insect is difficult for developing immunity to drugs.
Embodiment
The applicant, on the basis of multiple feverfew being killed to the active extensively screening of mosquito larvae, finds that the active ingredient of welted thistle is killed the mosquito larvae activity, and culex pipiens pallens larvae is shown to higher cytotoxicity.The applicant is main active ingredient and adds auxiliary agent formulated welted thistle complete stool fine powder or welted thistle extract, and the preparation form is soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion, wherein:
Soluble liquid is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%;
Wetting powder is prepared by following raw materials by weight:
Welted thistle complete stool fine powder: 40%～60%, wetting agent: 1%～5%, dispersant: 5%～15%, surplus is filler, the percentage by weight sum of raw material is 100%;
Water dispersible granules is prepared by following raw materials by weight:
The welted thistle extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Granule is prepared by following raw materials by weight:
Welted thistle extract: 5%～20%; Dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Microemulsion is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, solvent 40%～84%, surfactant 1%～20%, the summation of raw material is 100%;
Aqueous emulsion is prepared by following raw materials by weight:
The welted thistle extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2～1%; Surplus is water, and the percentage by weight sum of raw material is 100%.
For a more clear understanding of the present invention and the drug effect of medicament of the present invention, below the specific embodiment completed according to technical solution of the present invention that provides by the inventor the present invention is described in further detail, these are only the present invention embodiment preferably, but are not limited to these embodiment.
It should be noted that, in following embodiment, it is raw material that the welted thistle extract adopts the welted thistle complete stool, uses industrial alcohol extract, and extract obtains through concentrated.
Emulsifier can be one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers and similar substance, castor oil and oxirane;
Organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide or solvent well known in the art;
Wetting agent can be one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Dispersant can be one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, lignin and derivative sulfonate thereof, carboxymethyl cellulose;
Disintegrant can be one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Binding agent can be selected bentonite or imvite;
Filler or carrier can be that common brick, clay, slag kaolin, diatomite, white carbon, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite;
Surfactant is one or more mixture of this area all kinds of surface reactive materials commonly used.
Antifreezing agent is ethylene glycol or propane diols;
Thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate.
Preparation Example 1: contain the preparation that the welted thistle extract kills the mosquito larvae soluble liquid
Take welted thistle extract 30kg, polyoxyethylene nonylphenol ether phosphate 15kg, ethanol 55kg add in the preparation still, are stirred well to transparently, get final product to such an extent that contain the soluble liquid 100kg of 30% welted thistle.
Preparation Example 2: contain the preparation that the welted thistle extract kills the mosquito larvae wetting powder
Take welted thistle meal 60kg, pulverize, cross 325 mesh sieves, and guarantee that 95% crushed material passes through 325 mesh sieves, after this fine powder is fully mixed with 25kg White Carbon black, 5kg sodium lignin sulfonate, 10kg dispersant NNO, get final product to such an extent that contain 60% welted thistle wettable insecticidal dust 100kg.
Preparation Example 3: contain the preparation that the welted thistle extract kills the mosquito larvae water dispersible granules
Take welted thistle extract 25kg, after adding 5kg wetting agent, 10kg lignin, 5kg sodium pyrophosphate, 53kg diatomite to stir, through pulverizing, obtain the order powder, the order powder is mixed with the 2kg imvite, then granulation, oven dry, screening, through quality inspection, must contain 25% welted thistle water dispersion granule 100kg.
Preparation Example 4: contain the preparation that the welted thistle extract kills the mosquito larvae granule
Take welted thistle extract 20Kg, add 5Kg dispersant ME, 10Kg imvite, 65Kg kaolin mixes, and then granulation, oven dry, screening namely obtain and contain 20% welted thistle extract particles agent 100Kg through quality inspection.
Preparation Example 5: contain the preparation that the welted thistle extract kills the mosquito larvae microemulsion
Take welted thistle extract 25kg and 20kg polyoxyethylene nonylphenol ether phosphate, be dissolved in 5kg methyl alcohol, above solution is heated to 40 ℃ in homogenizer, under high-speed stirred, add deionized water 50kg; Dropwise, then stir 45min, cooling, must contain the microemulsion 100kg of 25% welted thistle extract.
Preparation Example 6: contain the preparation that the welted thistle extract kills the mosquito larvae aqueous emulsion
Take welted thistle extract 25kg, dissolve with methyl alcohol 5kg, under agitation add polyoxyethylene nonylphenol ether phosphate 20kg, stir, add deionized water 50kg, get final product to such an extent that contain the aqueous emulsion 100kg of 25% welted thistle extract.
In above-mentioned Preparation Example, the consumption of welted thistle complete stool fine powder or welted thistle extract has only been selected a kind of, be used to testing investigation.Certainly, in the making for preparing soluble liquid, wetting powder, water dispersible granules, granule, microemulsion or aqueous emulsion, in the scope that the present invention requires, all can access qualified preparation.
EXPERIMENTAL EXAMPLE 1: the toxicity of welted thistle ethanol extract Culex pipiens pallens 3 instar larvaes is measured
1.1 examination worm
Culex pipiens pallens Culex pipiens pallens, Nuisanceless Pesticide Research Service Center, Xibei Agroforestry Science and T's cultivation.
1.2 reagent agent
The welted thistle ethanol extract, extracted and obtain from welted thistle by Nuisanceless Pesticide Research Service Center, Xibei Agroforestry Science and T.
1.3 give birth to the survey method
The immersion method of WHO recommendation is adopted in this experiment to the mensuration of culex pipiens pallens larvae toxic action.Concrete operations are as follows: during mensuration, get the welted thistle ethanol extract and spend the liquid that chlorine water is diluted to certain multiple.In the 100ml beaker, add respectively 25ml dechlorination air water, then introduce 15 in the same sizes, health, strong Culex pipiens pallens 3 instar larvaes, last taking liquid 25ml joins in small beaker.Be placed in (26 ± 1) ℃, humidity (70 ± 10) %, illumination 12:12(L:D) under condition, respectively at 6h, 24h check result, calculate lethality and corrected mortality.The vibration beaker, and touch the examination worm with blunt-ended forceps, if the examination worm is motionless, namely be judged to death.Each sample triplicate, make solvent control with the ethanol of respective volume mark, and make blank with clear water at every turn.
1.4 results and analysis
Adopt immersion method, system measurement the cytotoxicity of welted thistle ethanol extract to Culex pipiens pallens 3 instar larvaes, added up the lethality of 6h, 24h, and tried to achieve the virulence curve, the results are shown in Table 1 and table 2.
The toxic effect of table 1 welted thistle ethanol extract to Culex pipiens pallens 3 instar larvaes
Table 2 welted thistle ethanol extract is to culex pipiens pallens larvae 24h Toxicity Determination result
| The medicament title | Virulence regression equation (Y=) | LC 50(mg/L) | Correlation coefficient r | Chi-square value X 2 |
| The welted thistle ethanol extract | 10.3144+4.7563X | 76.32 | 0.9514 | 1.78 |
As can be known by above-mentioned two tables, the welted thistle ethanol extract has cytotoxicity preferably to culex pipiens pallens larvae.
EXPERIMENTAL EXAMPLE 2: contain the thing source that the welted thistle extract plants and kill mosquito larvae agent kill mosquito field trial
For the drug effect situation that the kill mosquito larva of mosquito larvae agent is killed in clear and definite six Plants sources, the applicant carried out the test of on-the-spot kill mosquito larva effect to this medicament in Yang Ling demonstration area, Shaanxi Province in 2011.
1.1 examination worm
The Culex pipiens pallens Culex pipiens pallens grown under the natural conditions of Yang Ling area, aedes albopictus Aedes albopictus.
1.2 reagent agent
Contain 30% welted thistle soluble liquid, medicament code name FL1;
Contain 60% welted thistle wetting powder, medicament code name FL2;
Contain 25% welted thistle water dispersible granules, medicament code name FL3;
Contain 20% welted thistle granule, medicament code name FL4;
Contain 25% welted thistle microemulsion, medicament code name FL5;
Contain 25% welted thistle aqueous emulsion, medicament code name FL6;
The standby granule of 1% peace, medicament code name 007, produced by BASF China;
20% methylpyridine phosphorus aqueous emulsion, medicament code name 008, profit chemical science and technology company produces by the yiyang, hunan sea.
1.3 test method
Get 40 Plastic Drums (bore 28cm, footpath, end 25cm, high 35cm), be used separately as experimental group (n=4) and control group (n=4).Bucket is placed on outdoor bosky meadow, in each barrel, puts into the sewage 10L(depth of water of being fetched by the evil dried rhizome of rehmannia and be about 20cm, surface area is about 0.055m
2), approximately 150 of mosquito larvaes, test after adaptation 1d.Use respectively FL1, FL2, FL3, FL4, FL5, FL6(are 1.0g/m by active ingredient
3), 007(is 0.5g/m by active ingredient
3), 008(is by active ingredient 0.8g/m
3).And to experimental group, each barrel of control group, added respectively 50 of the mosquito larvaes of catching back from the evil dried rhizome of rehmannia in the 12nd day, the 26th day after on-test.
1.4 density survey method
Use the special-purpose bailer (capacity is about 200ml) of investigation mosquito larvae density, along the barrel edge water surface, choose mosquito larvae density higher part position and bail once, the counting mosquito larvae.1d, 7d, 14d, 21d, 28d and 35d before dispenser after 1d and dispenser respectively investigates 1 time, investigates altogether 7 times.
1.5 result is calculated
1.6 results and analysis
Adopt the Plastic Drum method to measure the test of 8 kinds of different medicaments to mosquito larvae poisoning drug effect, the results are shown in Table 3.As shown in Table 3, at 1.0g/m
3Under dosage, the plant resource that contains welted thistle kills the mosquito larvae agent after processing one day, and mosquito larvae density descends all over 90%, except FL4(contains 20% welted thistle extract particles agent), the rate of descent still had over 80% in the 28th day after processing.Simultaneously, in 28 days after processing, the plant resource of 6 kinds of welted thistle prepared by above-described embodiment kills the RPI of mosquito larvae agent all lower than 50, illustrates mosquito larvae is had to control efficiency preferably.In addition, whole control efficiency and chemistry commonly used that the mosquito larvae agent is killed in this 6 Plants source kill the standby granule of mosquito larvae agent 007(1% peace) close, be better than 008(20% methylpyridine phosphorus aqueous emulsion).
The different medicaments of table 3:8 kind are to mosquito larvae cytotoxicity result
Above-mentioned 6 kinds of plant resources that contain welted thistle kill during the mosquito larvae agent tests at the scene, quick-acting is preferably not only arranged, also to kill the mosquito larvae agent suitable with chemistry for lasting effect, and to non-target organism and environmental friendliness, therefore very applicable in water source processing, gardens water body facility and family daily life, have very large application and popularization value.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can to some corrections of do or improvement, this will be apparent to those skilled in the art.Therefore, these corrections or the improvement done without departing from theon the basis of the spirit of the present invention, all belong to protection scope of the present invention.
Claims (2)
1. a plant resource that contains welted thistle active ingredient kills the mosquito larvae agent, it is characterized in that, this plant resource made kills the mosquito larvae agent to be active ingredient by the welted thistle extract and to add auxiliary agent formulated, and the preparation form is soluble liquid, water dispersible granules, granule, microemulsion or aqueous emulsion, wherein:
Described soluble liquid is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, emulsifier: 10%～20%, surplus is solvent, the percentage by weight sum of raw material is 100%;
Described water dispersible granules is prepared by following raw materials by weight:
The welted thistle extract: 10%～50%, wetting agent: 1%～10%; Dispersant: 2%～10%, disintegrant: 5%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described granule is prepared by following raw materials by weight:
Welted thistle extract: 5%～20%; Dispersant: 1%～5%, binding agent: 1%～10%, all the other are carrier, the percentage by weight sum of raw material is 100%;
Described microemulsion is prepared by following raw materials by weight:
The welted thistle extract: 10%～30%, solvent: 40%～84%, surfactant: 1%～20%, the summation of raw material is 100%, described solvent is methyl alcohol;
Described aqueous emulsion is prepared by following raw materials by weight:
The welted thistle extract: 10%～50%, organic solvent: 0～30%, surfactant: 5%～20%, antifreezing agent: 4%～10%, thickener: 0.2～1%; Surplus is water, and the percentage by weight sum of raw material is 100%;
Described emulsifier is one or more mixture in the addition product, aralkyl phenol polyethenoxy ether formaldehyde condensation products of alkyl benzene sulfonate, alkylphenol polyoxyethylene class, phenethyl phenol polyethenoxy ethers, polyoxypropylene ethers, castor oil and oxirane;
Described organic solvent is one or more mixtures in ethyl acetate, cyclohexanone, ethanol, methyl alcohol, dimethyl formamide;
Described wetting agent is one or more the mixture in alkylaryl sulfonates, alkylbenzenesulfonate, alkyl sulfate, sulphonyl succinate, lignosulfonates;
Described dispersant is one or more the mixture in naphthalenesulfonate formaldehyde condensation compound, carboxymethyl cellulose;
Described disintegrant is one or more the mixture in sodium pyrophosphate, potassium pyrophosphate, sodium phosphate trimer, sodium dihydrogen phosphate and polysaccharide;
Described binding agent is bentonite and imvite;
Described filler or carrier are that common brick, clay, slag kaolin, diatomite, white carbon, granular float stone, perlite, people's granulation load one or more the mixture in body, gangue, vermiculite;
Described surfactant is the polyoxyethylene nonylphenol ether phosphate;
Described antifreezing agent is ethylene glycol or propane diols;
Described thickener is one or more the mixture in polyvinyl alcohol, xanthans, sodium carboxymethylcellulose, Magnesiumaluminumsilicate;
It is raw material that described welted thistle extract adopts the welted thistle complete stool, uses industrial alcohol extract, and extract obtains through concentrated; Concrete preparation method is:
Dry welted thistle plant is pulverized, cross 40 mesh sieves;
With 3～4 times of industrial alcohols to welted thistle crushed material quality, be solvent, ultrasonic extraction 1h under 50 ℃～60 ℃ conditions;
By the method for Vacuum Concentration, the welted thistle extract is concentrated into and the weight such as the welted thistle raw meal minces, obtain the welted thistle extract.
2. the plant resource that contains welted thistle active ingredient claimed in claim 1 kills the preparation method of mosquito larvae agent, it is characterized in that, carries out according to the following steps:
A, dry welted thistle plant is pulverized, cross 40 mesh sieves;
B, be solvent with 3～4 times of industrial alcohols to welted thistle crushed material quality, ultrasonic extraction 1h under 50 ℃～60 ℃ conditions;
The method of C, use Vacuum Concentration, be concentrated into the welted thistle extract and the weight such as the welted thistle raw meal minces, and obtains the welted thistle extract;
D, in the preparation still, according to proportional quantity, by welted thistle extract, emulsifier, solvent, in the preparation still, stir transparently, through quality inspection, namely obtain soluble liquid;
E, mix according to the water dispersible granules proportional quantity, after stirring, obtain the order powder through pulverizing, the order powder is mixed with binding agent, then granulation, oven dry, screening, pass through quality inspection and namely obtain water dispersible granules;
F, in the absorption mixer, according to the granule proportional quantity, welted thistle extract, dispersant, binding agent are mixed, after quality inspection, i.e. granulation agent;
G, in reactor, according to the microemulsion proportional quantity, welted thistle extract, organic solvent, surfactant, antifreezing agent and water are mixed, in reactor, stir transparently, through quality inspection, namely obtain microemulsion;
H, according to the aqueous emulsion proportional quantity, welted thistle extract, organic solvent, surfactant, antifreezing agent, thickener and water are mixed, emulsion dispersion under the effect of high-speed shearing machine, after quality inspection, namely make aqueous emulsion.
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|---|---|---|---|---|
| KR100516560B1 (en) * | 2002-01-29 | 2005-09-22 | 삼진제약주식회사 | Hypoglycemic and anagesic composition |
| US6623766B1 (en) * | 2002-03-21 | 2003-09-23 | Council Of Scientific And Industrial Research | Process for insecticidal formulation effective in controlling malarial vector, mosquitoes |
| US20070224232A1 (en) * | 2006-03-27 | 2007-09-27 | Jeffrey Sherwood | Composition and method to repel insects |
| CA2733779A1 (en) * | 2008-08-13 | 2010-02-18 | James Messina | Broad spectrum animal repellent and method |
| JP2010126486A (en) * | 2008-11-27 | 2010-06-10 | Bio Eco:Kk | New insect pest repellent |
| WO2010145655A1 (en) * | 2009-06-19 | 2010-12-23 | Rexcure V/Jan Enggaard | Herbal extract composition comprising petroselinum and ocimum extract |
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2012
- 2012-06-22 CN CN2012102079540A patent/CN102726456B/en active Active
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