CN104082322B - A kind of containing Nylar with the insecticide acaricide composition of Bifenazate - Google Patents

Abstract

The invention discloses a kind of containing Nylar with the insecticide acaricide composition of Bifenazate.This insecticide acaricide composition includes the first effective ingredient Nylar and the second effective ingredient Bifenazate and conventional auxiliary element, and wherein the weight ratio of Nylar and Bifenazate is 30:1～1:30；Great number of indoor and outdoor experiments show that after being compounded, the present invention has obvious synergistic function, expands insecticidal spectrum, can be used for the various pests prevented and treated agriculturally, such as red spider, aleyrodid, wood louse, thrips, scale insect etc.；Simultaneously because decrease Pesticide use amount, reduce pesticide residual quantity on crops, alleviate the pollution to environment, delayed the generation of pest resistance to insecticide.

Description

A kind of containing Nylar with the insecticide acaricide composition of Bifenazate

Technical field

The present invention relates to composition pesticide and application thereof, with Nylar and Bifenazate be specifically The composition pesticide of effective ingredient, it is adaptable to preventing and treating red spider, aleyrodid, wood louse, thrips, aphid, shell The agricultural pests such as worm.

Background technology

Nylar: belonging to the novel pesticide of juvenoid, the mechanism of action is pressing down of chitin synthetase Preparation.To Bemisia tabaci, scale insect, diamondback moth, beet armyworm, Prodenia litura, pear psyllid, thrips etc. Having good prevention effect, this product has good prevention effect to the sanitary insect pest such as fly, mosquito simultaneously.

Bifenazate: be a kind of novel hydrazine ester type compound, the mechanism of action is demodicid mite class γ-aminobutyric acid (GABA) antagonist.It is effective to each life stage of demodicid mite, have ovicidal activity with to becoming demodicid mite to hit Fall active, and the lasting period is long, lasting period about 14d.Recommend dosage range interior to crop safety.

The resistance problems of agricultural pests is a global problem, and always agricultural science and technology worker pays close attention to Emphasis problem.Along with to the continuity year in year out of Chemical Control of Harmful Insects, the increase of Pesticide use amount with And the impact of the not factor such as scientifical use pesticide, cause pest resistance day by day serious, produce the species of insect pests of resistance Class is on the increase.Simultaneously as the use pesticide of high intensity, result in Practice for Pesticide Residue in Agricultural Products exceed standard, dirty The dye series of problems such as environment and peasant's drug cost increase, is unfavorable for the sustainable development of agricultural.

Therefore, develop efficiently, low toxicity, low-residual, the different mechanism of action, have again Synergistic to make simultaneously Complex preparation, not only facilitate the generation delaying pest resistance to insecticide, but also pesticide product can be extended In the service life planted, reduce using dosage, cost-effective, reduce the pollution to environment.

The compounded formula of Nylar and Bifenazate is screened and conducts in-depth research by the present inventor, finds pyrrole third Ether and Bifenazate compound, and have obvious synergistic function in the range of certain compound proportion, The most in actual use the most simultaneously, expand insecticidal spectrum, to insect agriculturally, as red spider, aleyrodid, Wood louse, thrips, scale insect etc. have outstanding prevention effect, after further study, complete the present invention.

Summary of the invention

It is an object of the invention to provide the insecticide acaricide composition of a kind of pyriproxyfen-containing and Bifenazate, this is multiple Join insecticide acaricide composition and there is obvious synergistic function, expand insecticidal spectrum, can be used for preventing and treating agricultural On red spider, aleyrodid, wood louse, thrips, the various pests such as scale insect.

Another object of the present invention is to the insecticide acaricide composition containing Nylar and Bifenazate, using In can reduce dosage, reduce pesticide residual quantity on crops, delay the generation of pest resistance to insecticide, It can also be made to be used alone to compare than single dose to the prevention effect of various insects and significantly improve, laborsaving, save money, Reduce farmer's burdens.

Technical solution of the present invention: a kind of containing Nylar with the insecticide acaricide composition of Bifenazate, with pyrrole third Ether and the weight ratio that Bifenazate is effective ingredient, Nylar and Bifenazate are 30:1～1:30, Nylar Being 1%～85% with Bifenazate weight summation percentage by weight in the composition, remaining allows to make in pesticide With with acceptable auxiliary element.

Described auxiliary element is solvent, emulsifying agent, wetting agent, dispersant, stabilizer, antifreezing agent, increasing One in thick dose, disintegrating agent, binding agent, defoamer, penetrating agent, synergist, fire retardant and filler or More than one combination, above material is in pesticidal preparations conventional known substance, according to being prepared as difference The formulations of pesticide and be varied from, but be not particularly limited.

The present invention can be prepared as any one dosage form being suitable in agricultural production using by known method, compares Good dosage form has suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wettable powder, ultra-low volume liquid Agent, microcapsule suspending agent and thermal fog.

Frequency of administration and the amount of application of the present composition have little with crops, insect, weather condition change Amount change, can reach, by using suitable dosage, the purpose effectively prevented and treated.

Compared with prior art, it is an advantage of the current invention that:

1, Nylar and Bifenazate compound and have synergistic function, are used alone than single dose and significantly improve Prevention effect to insect, expands insecticidal spectrum simultaneously, solves when single dose is used alone some insect The defect of weak effect.

2, Nylar and two kinds of effective ingredient of Bifenazate compound, and decrease Pesticide use amount, reduce use Cost, alleviate the pollution to environment, delayed the generation of pest resistance to insecticide, add the use longevity of pesticide Life.

Detailed description of the invention

In order to be more fully understood that the essence of the present invention, below in conjunction with embodiment, present disclosure is made further Illustrate, but limitation of the present invention can not be considered as.

(1) Formulation Example

In following examples, effective ingredient uses the 95% former medicine of Nylar and the former medicine of 97% Bifenazate, each component Percentage composition is weight percentage.

Embodiment 1:20% Nylar Bifenazate suspending agent.

Nylar 5%, Bifenazate 15%, alkylnaphthalene sulfonate 15%, alkylphenol-polyethenoxy base ether phosphate 15%, xanthan gum 2%, glycerol 2%, silicone oil 0.1%, deionized water supplies 100%.By above-mentioned effective ingredient, Dispersant, wetting agent, thickening agent, antifreezing agent, defoamer and deionized water mixing, disperse through high speed shear, Sand milling in sand mill, the high dispersive formed in water-medium, stable suspension system, can be prepared by 20% Nylar Bifenazate suspending agent.

Embodiment 2:35% Nylar Bifenazate aqueous emulsion.

Nylar 8%, Bifenazate 27%, vegetable oil resin 20%, NPE 10%, poly- Carboxylate 10%, sodium sorbate 1%, glycerol 1%, deionized water supplies 100%.By above-mentioned effective ingredient, Solvent, emulsifying agent, dispersant and stabilizer are mixed to form oil phase, and antifreezing agent dissolves formation aqueous phase in water, Slowly oil phase is added in aqueous phase under cutter effect, and continue to shear about 30 minutes, can be prepared by 35 The Nylar Bifenazate aqueous emulsion of %.

Embodiment 3:40% Nylar Bifenazate microemulsion.

Nylar 25%, Bifenazate 15%, N-ketopyrrolidine 20%, styrylphenol polyoxyethylene ether 15%, Sodium citrate 2%, organosilicon 1%, azone 2%, deionized water supplies 100%.By complete for effective ingredient solvent CL, then adds emulsifying agent, stabilizer, penetrating agent, synergist mix homogeneously, is eventually adding Ionized water, after being sufficiently stirred for, can be prepared by the Nylar Bifenazate microemulsion of 40%.

Embodiment 4:70% Nylar Bifenazate wettable powder.

Nylar 20%, Bifenazate 50%, alkylaryl polyoxyethylene ether 8%, calcium dodecyl benzene sulfonate 10%, kieselguhr supplies 100%.By above-mentioned, effective ingredient, dispersant, wetting agent and filler are mixed, machinery Again through comminution by gas stream, mix homogeneously after pulverizing, can be prepared by 70% Nylar Bifenazate wettable powder.

Embodiment 5:50% Nylar Bifenazate water dispersible granules.

Nylar 15%, Bifenazate 35%, naphthalenesulfonate formaldehyde condensation compound 15%, alkyl sulfate 10%, Carbamide 2%, polyvinyl alcohol 2%, Kaolin supplies 100%.By above-mentioned effective ingredient, dispersant, wetting agent, Disintegrating agent, binding agent and filler mix homogeneously, pulverize with micro jet, through mediating, is subsequently adding Fluidized-bed granulation dryer carries out pelletize, dry, screening, can be prepared by 50% Nylar Bifenazate water Dispersible granule.

Embodiment 6:10% Nylar Bifenazate ultra low volume liquids.

Nylar 4%, Bifenazate 6%, N-Methyl pyrrolidone 20%, calcium dodecyl benzene sulfonate 5%, castor Oleum Sesami polyoxyethylene ether 3%, azone 2.5%, soybean oil complements to 100%.Above-mentioned effective ingredient solvent is stirred After mixing dissolving, add other auxiliary agent, be thoroughly mixed uniformly, can be prepared by 10% Nylar biphenyl hydrazine Ester ultra low volume liquids.

Embodiment 7:30% Nylar Bifenazate microcapsule suspending agent.

Nylar 12%, Bifenazate 18%, sodium alginate and deformation lactoprotein 10%, Cotton seed oil methyl ester 15%, Castor oil polyoxyethylene ether 5%, polyoxyethylene carboxylate 3%, sodium hydroxide 2%, deionized water complements to 100%.By above-mentioned effective ingredient, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, Under shearing condition, oil phase is joined containing emulsifying agent, pH adjusting agent, dispersant aqueous phase solution in, remaining Amount deionized water is supplied, and bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, can make Obtain 30% Nylar Bifenazate microcapsule suspending agent.

Embodiment 8:15% Nylar Bifenazate thermal fog.

Nylar 10%, Bifenazate 5%, NOP 20%, polycarboxylate 10%, dodecyl Benzenesulfonic acid calcium 5%, azone 2%, triphenyl phosphate 2%, Cotton seed oil complements to 100%.By above-mentioned effective ingredient With in the reaction vessel that solvent puts into band stirring, after effective ingredient fully dissolves, add other auxiliary agent, It is sufficiently stirred for about 60 minutes so that it is mix homogeneously, can be prepared by 15% Nylar Bifenazate thermal fog. (2) indoor biological determination of activity and the field efficacy of insecticide acaricide composition of the present invention is verified.

1, Nylar and the Bifenazate indoor joint toxicity measuring to scale insect.

For examination worm: select be collected in citrus orchard and raise the scale insect nymph of breeding in indoor.

Reagent agent: the 95% former medicine of Nylar and the former medicine of 97% Bifenazate.

Test method: using nebulization to be measured, concrete grammar is as follows.

Select scale insect nymph healthy, that age is consistent at laboratory, put into the cultivation with Citrus leaf In ware, every ware 40 cephalont, often process and set 4 repetitions, with potter spray tower under 50PSI pressure Spraying, every time one ware of spray, every ware spraying liquid 1ml, takes out culture dish, then will process after sedimentation 1min The culture dish crossed puts into 25 DEG C, cultivates in the illumination box of 12H/12H, if having accordingly without medicament The process of machine solvent is as comparison.After process, 72h investigation examination worm death condition, records total borer population and dead borer population.

Carry out statistical analysis with DPS statistical analysis software, calculate the LC of each medicament₅₀, and according to Sun Yun abundant method meter Calculate the co-toxicity coefficient (CTC value) of mixture.

Actual measurement toxicity index (ATI)=(standard agent LC₅₀/ reagent agent LC₅₀)×100。

Percentage composition+B medicament the poison of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture The percentage composition of B in power index × mixture.

Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] ×100。

According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 Show as potentiation；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients (CTC) ＜ 120 shows as summation action.

Table 1, Nylar and the Bifenazate indoor joint toxicity measuring to scale insect.

Medicament title and proportioning (weight ratio)	LC50(mg/L)	ATI	TTI	CTC
					Nylar	7.82	100.00	-	-
Bifenazate	34.28	22.81	-	-
					Nylar: Bifenazate (30:1)	6.13	127.57	97.51	130.83
Nylar: Bifenazate (20:1)	5.69	137.43	96.32	142.68
					Nylar: Bifenazate (10:1)	5.34	146.44	92.98	157.50
Nylar: Bifenazate (5:1)	5.06	154.55	87.14	177.36
					Nylar: Bifenazate (1:1)	6.37	122.76	61.41	199.90
Nylar: Bifenazate (1:5)	10.82	72.27	35.68	202.55
					Nylar: Bifenazate (1:10)	14.21	55.03	29.83	184.48
Nylar: Bifenazate (1:20)	19.16	40.81	26.49	154.06
					Nylar: Bifenazate (1:30)	23.27	33.61	25.30	132.85

As it can be seen from table 1 Nylar and Bifenazate are multiple in the range of 30:1～1:30 (by weight) Timing, co-toxicity coefficient (CTC) is all higher than 120, scale insect is shown synergistic function, it is seen that pyrrole third Ether and Bifenazate compound has reasonability and feasibility.

2, Nylar and the Bifenazate indoor joint toxicity measuring to citrus red mite.

For examination worm: select be collected in citrus orchard and raise the red spider female one-tenth demodicid mite of breeding in indoor.

Reagent agent: the 95% former medicine of Nylar and the former medicine of 97% Bifenazate.

Test method uses leaf butterfly nebulization, and concrete operation method is as follows:

Choose the Citrus leaf of healthy growth, make leaf butterfly with card punch, in culture dish, place a wet sponge Block, it puts filter paper, foliation butterfly on filter paper, and every ware puts 2 pieces of leaf butterflies, select health, age consistent Female one-tenth demodicid mite is inoculated on leaf butterfly citrus red mite, and every leaf butterfly inoculates 20, often processes and sets 4 repetitions.Will The culture dish being connected to leaf butterfly is placed under potter spray tower, sprays under 50PSI pressure, and spray amount is 1ml, Take out culture dish after sedimentation 1min, then the culture dish processed is put into 25 DEG C, 12H/12H illumination cultivation Cultivate in case, if the process of the corresponding organic solvent without medicament is as comparison.48h investigation examination after process Worm death condition, records total borer population and dead borer population.

Carry out statistical analysis with DPS statistical analysis software, calculate the LC of each medicament₅₀, and according to Sun Yun abundant method meter Calculate the co-toxicity coefficient (CTC value) of mixture.

Actual measurement toxicity index (ATI)=(standard agent LC₅₀/ reagent agent LC₅₀)×100。

Percentage composition+B medicament the poison of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture The percentage composition of B in power index × mixture.

Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] ×100。

According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 Show as potentiation；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients (CTC) ＜ 120 shows as summation action.

From table 2 it can be seen that Nylar and Bifenazate are multiple in the range of 30:1～1:30 (by weight) Timing, co-toxicity coefficient (CTC) is all higher than 120, citrus red mite is shown synergistic function, it is seen that Nylar and Bifenazate compound has reasonability and feasibility.

Table 2, Nylar and the Bifenazate indoor joint toxicity measuring to citrus red mite.

Medicament title and proportioning (weight ratio)	LC50(mg/L)	ATI	TTI	CTC
					Nylar	24.29	100.00	-	-
Bifenazate	12.67	191.71	-	-
					Nylar: Bifenazate (30:1)	17.18	141.39	102.96	137.33
Nylar: Bifenazate (20:1)	15.36	158.14	104.37	151.52
					Nylar: Bifenazate (10:1)	12.89	188.44	108.34	173.93
Nylar: Bifenazate (5:1)	10.74	226.16	115.29	196.17
					Nylar: Bifenazate (1:1)	8.12	299.14	145.86	205.09
Nylar: Bifenazate (1:5)	7.28	333.65	176.43	189.11
					Nylar: Bifenazate (1:10)	7.96	305.15	183.37	166.41
Nylar: Bifenazate (1:20)	8.81	275.71	187.34	147.17
					Nylar: Bifenazate (1:30)	10.16	239.07	188.75	126.66

3, Nylar and the compounding field control effectiveness test to scale insect of Bifenazate.

Embodiment 2 (35% Nylar Bifenazate aqueous emulsion) is used to be used for preventing and treating Citrus scale insect, dispenser Front investigation insect population radix, after medicine, 7d, 14d, 30d investigate residual borer population alive respectively, and investigation Shi Mei community looks into 2 Strain, every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, and each community looks into 40 blades altogether, records Borer population alive, calculates prevention effect.Prevention effect computational methods are as follows:

Preventive effect (%)=(1-CK₁×Pt₁/CK₂×Pt₂)×100。

Wherein: CK₁Represent insect population number before the medicine of check plot；Pt₁Represent insect population number after treatment region medicine；

CK₂Represent insect population number after the medicine of check plot；Pt₂Represent insect population number before treatment region medicine；

During from table 3 it can be seen that 35% Nylar Bifenazate aqueous emulsion uses 1000-1500 times, after medicine 7d, 14d, 30d are superior to each single dose to the preventive effect of scale insect and are used alone, and after medicine, 30d preventive effect is the most simultaneously Reach more than 80%, illustrate that this compound drug has good lasting effect.During test survey, do not find that this is multiple Dose out powders produces poisoning to mandarin tree.

Table 3, each result of the test processing chemical control scale insect.

4, Nylar and the compounding field control effectiveness test to citrus red mite of Bifenazate.

Embodiment 5 (50% Nylar Bifenazate water dispersible granules) is used to be used for preventing and treating citrus red mite, Investigating insect population radix before dispenser, after medicine, 7d, 14d, 30d investigate residual demodicid mite number alive respectively, investigate Shi Mei community Looking into 2 strains, every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, and each community looks into 40 blades altogether, Record demodicid mite number of living, calculate prevention effect.Prevention effect computational methods are as follows:

Prevention effect (%)=(1-CK₁×Pt₁/CK₂×Pt₂)×100。

Wherein: CK₁Represent insect population number before the medicine of check plot；Pt₁Represent insect population number after treatment region medicine；

CK₂Represent insect population number after the medicine of check plot；Pt₂Represent insect population number before treatment region medicine；

Table 4, each result of the test processing chemical control citrus red mite.

During from table 4, it can be seen that 50% Nylar Bifenazate water dispersible granules uses 2500-3000 times, After medicine, 7d, 14d, 30d are superior to each single dose to the preventive effect of citrus red mite and are used alone, 30d after medicine simultaneously Preventive effect the most still reaches more than 80%, illustrates that this compound drug has good lasting effect.During test survey not Find that this compound drug produces poisoning to mandarin tree.

In sum, the compound insecticidal mite killing that the present invention uses two kinds of active component to be Nylar and Bifenazate Compositions, has synergistic function, and compared with existing unitary agent, insecticidal effect significantly improves, and Lasting period is long, to crop safety, is worth popularization and application in agricultural production.

Claims (4)

1. one kind contains Nylar and the insecticide acaricide composition of Bifenazate, it is characterised in that: effective ingredient is Nylar and Bifenazate, and wherein the weight ratio of Nylar and Bifenazate is 30:1～1:30, Nylar and Bifenazate gross weight percentage composition in the composition is 1～85%.

It is the most according to claim 1 a kind of containing Nylar with the insecticide acaricide composition of Bifenazate, it is characterised in that: described compositions is possibly together with insecticides adjuvant, in order to make the application forms of applicable agricultural use.

3. the purposes of the insect agriculturally of a kind of insecticide acaricide composition preventing and treating containing Nylar and Bifenazate described in claim 1.

Purposes the most according to claim 3, it is characterised in that: described insect is red spider, aleyrodid, wood louse, thrips, aphid, scale insect.