CN103651507B - A kind of Pesticidal combination containing cycolxylidin and nimbin - Google Patents
A kind of Pesticidal combination containing cycolxylidin and nimbin Download PDFInfo
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- CN103651507B CN103651507B CN201310658583.2A CN201310658583A CN103651507B CN 103651507 B CN103651507 B CN 103651507B CN 201310658583 A CN201310658583 A CN 201310658583A CN 103651507 B CN103651507 B CN 103651507B
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- cycolxylidin
- nimbin
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Abstract
The invention discloses the Pesticidal combination of cycolxylidin and azadirachtin complex, the two compositely can be prepared into the formulation be agriculturally suitable for, such as missible oil, wetting powder, water dispersible granules, suspending agent, oil-suspending agent, ultra low volume liquids, electrostatic oil agent or dry suspending agent, in order to control relevant insect agriculturally, after cycolxylidin and azadirachtin complex, insecticidal effect strengthens, Pesticide use amount reduces, safer to environment, more environmental protection.
Description
Technical field
The invention belongs to pesticide field, the mixture Pesticidal combination containing cycolxylidin and nimbin.
Background technology
Cycolxylidin is anabasine insecticide, is formulated by Wuhan Engineering Univ, chemical name: 1-(2,3-glycidyl)-N-Nitroimidazoline-2-base amine, chemical molecular formula C
6h
10n
4o
3.Have interior suction, stomach toxicity and action of contace poison to insect, have the insecticidal spectrum the same with insecticide variety Imidacloprid the most salable on current world market and insecticidal effect, its lasting effect is also higher than Imidacloprid, and toxicity is lower.Cycolxylidin can be used for preventing and treating the homoptera pest on crops.As a kind of anabasine insecticide, in use there is resistance risk in cycolxylidin, and rationally mixed with dissimilar insecticide, for fully effectively promoting cycolxylidin, extending its service life and having important function.
Nimbin (Azadirachtin) is from isolated a kind of insecticides such as the fruits printing chinaberry, there is insecticidal activity to more than 10 orders more than 400 kind of agriculture, woods, storage and sanitary insect pests such as diamond-back moth, cabbage caterpillar, locusts, to multiple nematode and fungi, also there is good killing action.To the virulence of insect, active and mechanism of action main manifestations is make insect antifeedant, avoid and keep away and suppress growing of insect to nimbin, the internal secretion of interference insect, make larva normally not cast off a skin and to pupate and cause insect dead, have that insect not easily develops immunity to drugs, efficiency time is long, be easy to degraded in the environment and to features such as high and warm blooded animal are nontoxic, be our times various countries most study, by the novel insecticide of environmental friendliness of universally acknowledged wide spectrum, efficient, low toxicity, low-residual.
The mixture of different pesticide species is the common methods of preventing and treating agriculture resistant insect.Screened by formulation of pesticide, filter out rational formula, can effectively improve actual control efficiency, reduce dosage, reduce costs, delay the generation of pest resistance to insecticide, extending the service life of medicament, is the important means of integrated pest management.The present inventor, on the basis of a large amount of indoor bioassay and field medicine effect test, finds cycolxylidin and nimbin mixedly has obvious synergistic effect to pest, and not cycolxylidin and nimbin relevant report used in combination at present.
Summary of the invention
The object of the present invention is to provide a kind of agricultural chemical composition for disinsection, the active ingredient of said composition is active component cycolxylidin and nimbin, said composition has obvious synergistic effect to control sucking pest, not only can reduce the usage amount of active ingredient, reduce use cost, the generation of pest resistance can also be delayed, for the improvement of resistant insect.In addition, the composition provide a kind of composition being more suitable for agricultural use, be particularly useful for the suckings pest such as aphid, plant hopper, aleyrodid, wood louse.
Technical scheme taked to achieve the object of the present invention is as follows:
Agricultural chemical composition for disinsection of the present invention, adopt active component cycolxylidin and nimbin to carry out composite, the weight ratio of the two is: 50:1-1:50, preferred 1:25-25:1, more preferably 20:1-1:10, especially preferably: 1:5-5:1.
The present invention can be processed into suitable various formulations according to the agricultural use of reality, comprising: wetting powder, water dispersible granules, suspending agent, oil-suspending agent, suspension emulsion, ultra low volume liquids, electrostatic oil agent or dry suspending agent.
In these preparations, in addition to the active ingredient (s, all containing surfactant, and the thinner such as organic solvent or cosolvent, carrier (filler) or water can also be contained according to different dosage form.Add other functional aids such as antifreeze, thickener, stabilizing agent, defoamer or disintegrant if desired.
Described auxiliary agent is one or more in dispersant NNO, lauryl sodium sulfate, Dispersant MF, sodium lignin sulfonate, polyvinyl alcohol, agriculture breast 600#, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, alkylphenol polyoxyethylene phosphate, naphthalene sulfonic acid formaldehyde condensation polymer, ammonium sulfate or agriculture breast 500#.
Described solvent is dimethylbenzene, one or more in ethylene glycol, dimethyl formamide or ethyl acetate.
Described carrier is one or more in white carbon, kaolin, precipitated calcium carbonate, potter's clay or water.
The present composition is applicable to the various pests in agricultural, is particularly useful for aphid, plant hopper, aleyrodid, wood louse etc.
Tool of the present invention has the following advantages:
1, multiple sucking pest agriculturally can effectively be prevented and treated, especially to excellent effect such as aphid, plant hopper, aleyrodid, wood louses.
2, active component described in composition composite after there is obvious synergistic effect, thus decrease usage amount and the use cost of active component, improve the safety of medicament to environment simultaneously.
3, the present invention has excellent synergistic function to controlling disease, can improve control efficiency, reduces the usage amount of agricultural chemicals, reduces the use cost of peasant.
4, toxicity of pesticide of the present invention is lower, residual less, and use safety is environmentally friendly, to infringement and the less pollution of ecotope, is conducive to protecting person poultry safety.
Embodiment
Below by embodiment, the invention will be further described.It should be understood that preparation method described in the embodiment of the present invention is only used for the present invention is described, instead of limitation of the present invention, under concept thereof of the present invention, all the scope of protection of present invention is belonged to the simple modifications of preparation method of the present invention.
In example of formulations, we introduce the detailed ratio of composition, and in BIOLOGICAL ACTIVITY EXAMPLES, we introduce the outstanding biologically active of composition in detail.First the preparation of Pesticidal combination is introduced.
This product is made up of active ingredient, auxiliary agent, solvent three part, the components such as former medicine, auxiliary agent, solvent are mixed in mixing kettle, then carry out sand milling by mixture suction sand mill, after active ingredient is sanded and is about 5 μm to particle diameter, suction blender mixes again.The various auxiliary agents added in this patent etc. can keep preparation stablizing under high temperature, low temperature, contribute to storage, transport, ensure drug effect.
Various auxiliary agents, solvent etc. that the present invention adds are market products, and pesticide producing commonly uses assistant agent.
Embodiment
Be described in further details originally bright below in conjunction with embodiment.But be not limited thereto.
Embodiment 140% cycolxylidin nimbin emulsion (1:3)
The former medicine of 10% cycolxylidin, 30% nimbin raw medicine, 8%N, N-dimethylformamide, 10%N methyl pyrrolidone, 10% dimethyl sulfoxide (DMSO), 10% acetone, 4% calcium dodecyl benzene sulfonate, 4% triphenoethyl benzene phenol polyethenoxy ether, 3% phenethyl phenolformaldehyde resin APEO, all the other are supplied with dimethylbenzene.Prepare in the usual way.
Embodiment 226% cycolxylidin nimbin suspending agent (25:1)
275 grams of deionized waters in suction agitator tank, by in 40 grams of dispersant NNO, 40 grams of Dispersant MFs, 50 grams of lauryl sodium sulfate, 30 grams of ethylene glycol, suction agitator tank, then limit is stirred 250 grams of cycolxylidin, 10 grams of nimbins, 5 grams of kaolin, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by material ball milling with a certain amount of flow, temperature controls less than 40 degree, and fineness crosses 325 mesh sieves, obtains 26% cycolxylidin nimbin suspending agent.
Embodiment 360% cycolxylidin nimbin wetting powder (10:10)
By nimbin 300 grams, cycolxylidin 300 grams, Dispersant MF 50 grams, dispersant NNO40 gram, lauryl sodium sulfate 30 grams, 280 grams, potter's clay, stirs, adopt comminution by gas stream processing, 60% cycolxylidin nimbin wetting powder.
Embodiment 450% cycolxylidin water dispersed nimbin granule (4:1)
By nimbin 400 grams, cycolxylidin 100 grams, white carbon 300 grams, dispersant NNO50 gram, lauryl sodium sulfate 40 grams, lightweight calcium titanate 20 grams, 90 grams, ammonium sulfate, mixes laggard air-flow crushing, in mixer, spray into and mediate agent deionized water about 180 grams, adjustment extrusion equipment, carries out extruder grain, it is qualified to dry to moisture under 50 ~ 80 DEG C of conditions, 50% cycolxylidin water dispersed nimbin granule.
Embodiment 516% cycolxylidin nimbin oil-suspending agent (1:15)
620 grams of methyl oleates in suction agitator tank, by in 40 grams of polyoxyethylene nonylphenol ether, 60 grams of castor oil polyoxyethylene ethers and 60 grams of agricultures breast 500#, suction agitator tank, then limit is stirred 10 grams of cycolxylidin, 150 grams of nimbins, 20 grams of organobentonites, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by material ball milling with a certain amount of flow, temperature controls less than 40 degree, and fineness crosses 325 mesh sieves, obtains 16% cycolxylidin nimbin oil-suspending agent.
Embodiment 65% cycolxylidin nimbin ultra low volume liquids (2:3)
With finished product ultra low volume liquids for weight 1000 grams calculating, cycolxylidin 20 grams, nimbin 30 grams, dimethyl formamide 50 grams, 50 grams, ethyl acetate, alkylphenol polyoxyethylene phosphate 50 grams, neopelex 55 grams, two wires oil solvent complements to 1000 grams, stirs 30 minutes, to completely transparent, detect qualified after be 5% cycolxylidin nimbin ultra low volume liquids.
Embodiment 73.5% cycolxylidin nimbin electrostatic oil agent (6:1)
With finished product electrostatic oil agent for weight 1000 grams calculating, cycolxylidin 30 grams, nimbin 5 grams, dimethyl formamide 40 grams, 20 grams, ethyl acetate, alkylphenol polyoxyethylene phosphate 30 grams, neopelex 45 grams, methyl oleate complements to 1000 grams, stirs 30 minutes, to completely transparent, detect qualified after be 3.5% cycolxylidin nimbin electrostatic oil agent.
Embodiment 850% cycolxylidin nimbin dry suspending agent (1:4)
By cycolxylidin 100 grams, nimbin 400 grams, 50 grams, alkylaryl polyoxyethylene polyoxypropylene ether, thermally coupled distillation columns 40 grams, Dispersant MF 60 grams, add in mixed solution, suction deionized water again 600 grams, stir, then coarse crushing is carried out with high-speed shearing machine, enter the fine grinding of two-stage sand mill again, white carbon 100 grams is added after levigate, enter the dry or granulation of pressure spray drying tower after kaolin 250 grams, make powdery or particulate-solid, detect qualified after be 50% cycolxylidin nimbin dry suspending agent.Identical with suspending agent effect after entering water during use, but bin stability is better than suspending agent again.
Toxicity Determination embodiment
1, reagent agent: the former medicine of 96% cycolxylidin, 95% nimbin raw medicine, cycolxylidin and nimbin different proportion mixture preparation;
2, for examination worm source: cabbage aphid;
3, method of testing: adopt leaching worm immersion method that two former medicines are all used a small amount of acetone solution, then become the solution of 5 concentration of equal difference with the tween water capacity easily dilutable of 0.1%, be diluted in for subsequent use in beaker, and with clear water in contrast.Cabbage aphid adult of the same size is flooded 2s in the liquid of leaching worm cage, is placed on after sucking unnecessary liquid in the culture dish of 9cm, be placed with fresh cabbage leaves in ware and cover.Every concentration process 10, repeats 3 times, if blank, checks lethality after 24h, and it is dead for touching polypide nonresponder by pulling needle.Lethality Abbott corrects for examination, then according to log concentration-lethality probability value analytical method, obtains virulence regression equation and the lethal concentration of 50.
4, the joint toxicity measuring method of different ratio: according to the toxicity test result of single dose, the method of above-mentioned 3 is adopted to measure the cycolxylidin of different ratio and nimbin, calculate LC50, and press abundant method calculating co-toxicity coefficient (CTC) of Sun Yun, the co-toxicity coefficient (CTC) >=120 of built agent shows as synergistic effect; CTC≤80 show as antagonism; 80<CTC<120 shows as summation action.
Table 1 Toxicity Determination result
As can be seen from Table 1, cycolxylidin and nimbin its co-toxicity coefficient under the proportioning of variable concentrations is all greater than 120, and this being described two kinds of compositions are composite has obvious synergistic effect.
After cycolxylidin of the present invention and azadirachtin complex, the control efficiency of controlling object is all significantly improved, illustrate that this compositely has obvious synergistic effect, greatly reduce the usage amount of active ingredient under equal control efficiency, thus reduce the harm of environment and delayed the resistance of insect.Reduce the drug cost of peasant, suggestion is promoted the use of.
Claims (8)
1. contain a Pesticidal combination for cycolxylidin and nimbin, it is characterized in that: active component is made up of cycolxylidin and nimbin, the mass ratio of cycolxylidin and nimbin is 1: 25-25: 1.
2. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 1, is characterized in that: the mass ratio of cycolxylidin and nimbin is 20: 1-1: 10.
3. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 1 and 2, is characterized in that: containing auxiliary agent normally used in pesticidal preparations, solvent, carrier to make the formulation of various applicable agricultural use.
4. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 3, it is characterized in that: described auxiliary agent is dispersant lauryl sodium sulfate, NP-10, sodium lignin sulfonate, polyvinyl alcohol, agriculture breast 600#, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, alkylphenol polyoxyethylene phosphate, naphthalene sulfonic acid formaldehyde condensation polymer or agriculture breast 500# in one or more.
5. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 4, is characterized in that: described solvent is dimethylbenzene, one or more in ethylene glycol, dimethyl formamide or ethyl acetate.
6. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 4, is characterized in that: described carrier is one or more in white carbon, kaolin, precipitated calcium carbonate or water.
7. a kind of Pesticidal combination containing cycolxylidin and nimbin according to claim 4, it is characterized in that: described formulation has missible oil, wetting powder, water dispersible granules, suspending agent, oil-suspending agent, ultra low volume liquids, electrostatic oil agent or dry suspending agent.
8. a kind of Pesticidal combination containing cycolxylidin and nimbin described in claim 1-7 any one is for preventing and treating the purposes of pest.
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| CN201310658583.2A CN103651507B (en) | 2013-11-29 | 2013-11-29 | A kind of Pesticidal combination containing cycolxylidin and nimbin |
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| CN201310658583.2A CN103651507B (en) | 2013-11-29 | 2013-11-29 | A kind of Pesticidal combination containing cycolxylidin and nimbin |
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| CN103651507B true CN103651507B (en) | 2015-08-26 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105660679A (en) * | 2016-02-25 | 2016-06-15 | 广西壮族自治区烟草公司百色市公司 | Electrostatic oiling agent containing SYP-9080 |
| CN107347903A (en) * | 2017-09-13 | 2017-11-17 | 佛山市瑞生通科技有限公司 | A kind of composition pesticide containing cycolxylidin and matrine |
| CN109315413A (en) * | 2018-11-15 | 2019-02-12 | 深圳职业技术学院 | A kind of nimbin ultra low volume liquids and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119646A (en) * | 1994-06-03 | 1996-04-03 | 三井东压化学株式会社 | Insecticidal tetrahydrofuran-compound |
| CN1411723A (en) * | 2002-10-09 | 2003-04-23 | 华南农业大学 | Nimbin and new nicotine pesticide mixed pesticide preparation |
| CN101503406A (en) * | 2008-12-17 | 2009-08-12 | 武汉工程大学 | 1-(1,2-epoxy propyl)-N-nitroimidazolene amine-2, preparation and use thereof |
| CN103271073A (en) * | 2013-06-18 | 2013-09-04 | 陕西农心作物科技有限公司 | Insecticidal composition containing epoxy worm moiety and buprofezin |
-
2013
- 2013-11-29 CN CN201310658583.2A patent/CN103651507B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119646A (en) * | 1994-06-03 | 1996-04-03 | 三井东压化学株式会社 | Insecticidal tetrahydrofuran-compound |
| CN1411723A (en) * | 2002-10-09 | 2003-04-23 | 华南农业大学 | Nimbin and new nicotine pesticide mixed pesticide preparation |
| CN101503406A (en) * | 2008-12-17 | 2009-08-12 | 武汉工程大学 | 1-(1,2-epoxy propyl)-N-nitroimidazolene amine-2, preparation and use thereof |
| CN103271073A (en) * | 2013-06-18 | 2013-09-04 | 陕西农心作物科技有限公司 | Insecticidal composition containing epoxy worm moiety and buprofezin |
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