CN101731250B - Fenazaquin-containing acaricidal composition - Google Patents
Fenazaquin-containing acaricidal composition Download PDFInfo
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- CN101731250B CN101731250B CN 201010004931 CN201010004931A CN101731250B CN 101731250 B CN101731250 B CN 101731250B CN 201010004931 CN201010004931 CN 201010004931 CN 201010004931 A CN201010004931 A CN 201010004931A CN 101731250 B CN101731250 B CN 101731250B
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- fenazaquin
- butyl ether
- ether urea
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Abstract
The invention discloses a fenazaquin-containing acaricidal composition. The acaricidal composition comprises fenazaquin and diafenthiuron serving as active ingredients, wherein the mass-portion ratio of fenazaquin to diafenthiuron is between 20:1 and 1:80. The compounding of fenazaquin and diafenthiuron has obvious synergism and can reduce dosage and delay the generation of the drug resistance of pest mites. The composition can be used to prevent and control the pest mites on fruit trees, cotton, vegetables and flowers and other crops.
Description
Technical field
The present invention relates to a kind of compound acaricide composition, be specially a kind of miticide composition that contains fenazaquin.
Background technology
Fenazaquin: English common name Fenazaquin, chemical name: 4-spy-butyl benzene ethyl quinazoline, molecular formula: C
20H
22N
20Its structural formula is:
This medicine is the quinolines miticide, through mitochondria and the chromosome set 1 of action of contace poison in insect cell, occupies the abutment of ubiquinone, and citrus, European red mite are had the better prevention effect, and the lasting period is long, to natural enemies security.Do not have cross resistance with existing miticide, be particularly suitable for preventing and treating the pest mite class that existing miticide is produced resistance.But under the selection pressure of a large amount of dispensers of single agent, agent is easy to generate pesticide resistance to the evil mite to the fenazaquin list, and fenazaquin to prevent and treat the cost of resistance evil mite higher relatively.
Butyl ether urea: another name methamidophos, boccaccio, English common name Diafenthiuron, chemical name: 1-tertiary butyl-3-(2,6-diisopropyl-4-Phenoxyphenyl) thiocarbamide, molecular formula: C
23H
32N
2OS.The butyl ether urea is a kind of novel Thiourea efficient insecticide, miticide, have tag, stomach toxicity, interior suction and fumigation action; Low toxicity changes the material with insecticidal activity under ultraviolet light, the insect that has produced serious resistance on the vegetables is had stronger activity.Can prevent and treat aphid, aleyrodid, leafhopper, noctuidae pests and evil mite on various crop and the flowers.But the agent of butyl ether urea list is used and is easy to generate pesticide resistance, and the performance of its drug effect receives weather effect big.
Mite pest is because its breeding cycle is short, and breeding amount is big, and mobility is little, and the selfing degree is high, is easy to generate resistance especially.Show that according to people's results of study to the Chunan County panonychus citri in 2007 such as Xaisur China local panonychus citri has improved 25 times to the resistance of pyridaben.In the serious zone of some mite classes harm, single agent control such as pyridaben, four mite piperazines, azacyclotin evil mite dosage is big, cost is high, weak effect, environmental pollution are serious.
Composite through the compound of different effects mechanism is to delay the effective means that the evil mite produces resistance and the improvement of resistance evil mite.Compounded combination with synergistic effect, the dose that can reduce agricultural chemicals is a spraying times, delays the drug-fast generation of disease mite.
Summary of the invention
The objective of the invention is: a kind of complex composition that contains fenazaquin is provided, and said composition has obvious synergistic effect, and the control spectrum is wide, can delay the characteristics that evil mite pesticide resistance produces.Another object of the present invention is to provide the application of said composition on agricultural evil mite.
The present invention realizes through following technical scheme:
A large amount of compound screening test and field trial that the inventor carries out after unexpected discovery fenazaquin and butyl ether urea are composite, show obvious synergistic effect to the evil mite, can delay the drug-fast generation of evil mite.
A kind of miticide composition with synergistic effect is characterized in that containing fenazaquin and butyl ether urea, and the mass ratio of fenazaquin and butyl ether urea is 20: 1-1: 80, and the preferred mass ratio is 10: 1-1: 30.
Described miticide composition, wherein the active ingredient total content is 5%-90%, all the other are auxiliary element.
The present composition can adopt prior art; As required; Active ingredient is added auxiliary agent and excipients process agricultural according to production technology well known by persons skilled in the art and go up available any formulation, preferred dosage form is missible oil, wetting powder, suspending agent, water dispersible granules and microemulsion.
Beneficial effect of the present invention is: 1. fenazaquin and the composite miticide composition of butyl ether urea, have obvious synergistic effect, and reduce effective ingredient consumption, improve control efficiency; 2. the acaricidal activity composition of different effects mechanism is composite, has synergistic effect, can effectively delay the drug-fast generation of evil mite, and can be used for the improvement of resistance evil mite; Lasting period long, reduced dosage and medication number of times, practice thrift cost, and reduce pollution environment.
Embodiment
Following examples are to further specify of the present invention, but the present invention is not limited thereto.
(1) prescription and preparation processing embodiment.What active component adopted in the embodiment of the invention is former medicine of 99% fenazaquin and the former medicine of 95% butyl ether urea.
Embodiment 1:42% fenazaquin butyl ether urea wetting powder
Fenazaquin 40.40g
Butyl ether urea 2.11g
Lauryl sodium sulfate (wetting agent) 3g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 5g
Kaolin (filler) is mended to 100g
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, promptly get 42% fenazaquin butyl ether urea wetting powder through airslide disintegrating mill pulverizing, screening.(mass ratio of fenazaquin and butyl ether urea is 20: 1)
Embodiment 2:22% fenazaquin butyl ether urea suspending agent
Fenazaquin 20.20g
Butyl ether urea 2.11g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreezing agent) 4g
Silicone oil (antifoaming agent) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine of pulverizing in advance and carrier, surfactant, antifreezing agent, water etc. are added in the husky mill still, porphyrize is again through the mixed suspending agent that gets of high speed shear.(mass ratio of fenazaquin and butyl ether urea is 10: 1)
Embodiment 3:24% fenazaquin butyl ether urea microemulsion
Fenazaquin 20.20g
Butyl ether urea 4.22g
N-Methyl pyrrolidone (cosolvent) 10g
Calcium dodecyl benzene sulfonate (emulsifier) 8g
Triphen ethyl-phenol polyoxyethylene (emulsifier) 5g
Deionized water complements to 100g
Former medicine, cosolvent, emulsifier are added together, make and be dissolved into even oil phase, slowly add in the entry under stirring,, be chilled to room temperature and make microemulsion again through the rapid phase inversion of agitating heating.(mass ratio of fenazaquin and butyl ether urea is 5: 1)
Embodiment 4:30% fenazaquin butyl ether urea missible oil
Fenazaquin 15.15g
Butyl ether urea 15.79g
Calcium dodecyl benzene sulfonate (emulsifier) 4g
Phenethyl phenol polyethenoxy ether (emulsifier) 4g
Xylol (solvent) is mended to 100g
To contain active component, emulsifier and solvent etc., add mixing kettle successively, stir, get 30% fenazaquin butyl ether urea missible oil in the ratio of filling a prescription.(mass ratio of fenazaquin and butyl ether urea is 1: 1)
Embodiment 5:60% fenazaquin butyl ether urea wetting powder
Fenazaquin 10.10g
Butyl ether urea 52.63g
Lauryl sodium sulfate (wetting agent) 3g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 5g
Kaolin (filler) is mended to 100g
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after airslide disintegrating mill is pulverized, promptly get 60% fenazaquin butyl ether urea wetting powder through screening again.(mass ratio of fenazaquin and butyl ether urea is 1: 5)
Embodiment 6:33% fenazaquin butyl ether urea missible oil
Fenazaquin 3.03g
Butyl ether urea 31.58g
Calcium dodecyl benzene sulfonate (emulsifier) 4g
Phenethyl phenol polyethenoxy ether (emulsifier) 4g
Xylol (solvent) is mended to 100g
Former medicine, emulsifier and the soluble additive etc. that will contain active component add mixing kettle successively in the ratio of filling a prescription, and stir, and get 33% fenazaquin butyl ether urea missible oil.(mass ratio of fenazaquin and butyl ether urea is 1: 10)
Embodiment 7:62% fenazaquin butyl ether urea suspending agent
Fenazaquin 2.11g
Butyl ether urea 60.60g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreezing agent) 4g
Silicone oil (antifoaming agent) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine of pulverizing in advance and carrier, surfactant, antifreezing agent, water etc. are added in the husky mill still, porphyrize is again through the mixed suspending agent that gets of high speed shear.(mass ratio of fenazaquin and butyl ether urea is 1: 30)
Embodiment 8:81% fenazaquin diafenthiuron water dispersible granule
Fenazaquin 1.01g
Butyl ether urea 84.21g
Neopelex (wetting agent) 3g
Lignin sodium sulphate (dispersant) 4g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 2g
Urea (disintegrant) 5g
Diatomite (filler) is mended to 100g
Said mixture is evenly mixed, and comminution by gas stream adds suitable quantity of water and kneading, and the mixture pelleting of gained promptly gets 81% fenazaquin diafenthiuron water dispersible granule.(mass ratio of fenazaquin and butyl ether urea is 1: 80)
(2) biological activity determination of the present composition and the test of pesticide effectiveness
1. Toxicity Determination
With the cotton tetranychid is subjects; Employing leaf dish spray-on process (with reference to " NY/T 1154.13-2008 agricultural chemicals indoor bioassay test rule insecticide. the 13rd part: leaf dish spray-on process "), the synergistic effect of measuring fenazaquin and the composite different proportion of butyl ether urea is big or small.Co-toxicity coefficient (CTC value) according to the abundant method calculation composition of Sun Yun:
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ confession reagent agent LC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC>=120, then the composition performance is synergistic effect.
Toxicity Determination on the composite cotton tetranychid of table 1 fenazaquin and butyl ether urea
| Handle | LC 50(mg/L) | ATI | TTI | CTC |
| Fenazaquin | 14.9 | 100 | ||
| The butyl ether urea | 24.62 | 60.52 |
| Fenazaquin 20: butyl ether urea 1 | 8.97 | 166.1 | 98.1 | 169.3 |
| Fenazaquin 10: butyl ether urea 1 | 8.21 | 181.5 | 96.4 | 188.2 |
| Fenazaquin 5: butyl ether urea 1 | 7.47 | 199.5 | 93.4 | 213.5 |
| Fenazaquin 1: butyl ether urea 1 | 7.52 | 198.1 | 80.3 | 246.9 |
| Fenazaquin 1: butyl ether urea 5 | 8.69 | 171.5 | 67.1 | 255.5 |
| Fenazaquin 1: butyl ether urea 10 | 9.75 | 152.8 | 64.1 | 238.4 |
| Fenazaquin 1: butyl ether urea 30 | 11.78 | 126.5 | 61.8 | 204.7 |
| Fenazaquin 1: butyl ether urea 80 | 18.56 | 80.3 | 61.0 | 131.6 |
Fenazaquin and butyl ether urea composite Toxicity Determination result on the cotton tetranychid show; Fenazaquin and butyl ether urea are composite at ratio range 20: 1-1: between 80, can both show synergistic effect, especially 10: 1-1: between 30; Synergistic effect is remarkable, and co-toxicity coefficient is at (table 1) more than 180.
2, the composite field controling test of fenazaquin and butyl ether urea to the cotton tetranychid
The whole strain spray-on process of knapsack sprayer is adopted in test; Zone relatively uniformly takes place in two spotted spider mite in the field, and every group of medicament selected the 5 strain cottons object of making investigation, and makes marks; Carry out the investigation of insect population radix, then carry out even spraying according to the extension rate and the application method of experimental scheme.Respectively at checking in 1 day, 7 days and 21 days behind the medicine, calculate field efficacy.
The composite field efficacy of table 2 fenazaquin and butyl ether urea to the cotton tetranychid
| 30% fenazaquin butyl ether urea missible oil (embodiment 4) | 3000 | 22.5g fenazaquin+22.5 butyl ether ureas | 85.4 | 91.7 | 93.3 |
| 60% fenazaquin butyl ether urea wetting powder (embodiment 5) | 2000 | 22.5g fenazaquin+112.5g butyl ether urea | 93.4 | 98.2 | 95.1 |
| 33% fenazaquin butyl ether urea missible oil (embodiment 6) | 2000 | 6.75g fenazaquin+67.5g butyl ether urea | 90.3 | 95.4 | 92.9 |
| 62% fenazaquin butyl ether urea suspending agent (embodiment 7) | 2000 | 4.5g fenazaquin+135g butyl ether urea | 91.1 | 94.8 | 90.9 |
| 81% fenazaquin diafenthiuron water dispersible granule (embodiment 8) | 2000 | 22.5g fenazaquin+200g butyl ether urea | 90.2 | 94.3 | 91.8 |
| CK (clear water contrast) | 0 | 0 | 0 | 0 | 0 |
Result of the test to the cotton tetranychid shows that fenazaquin and butyl ether urea are 20: 1-1: in 80 the ratio range, have synergistic effect.Can find out from table 2, compare with butyl ether urea list agent preventive effect with fenazaquin that compound drug is under the situation that effective ingredient consumption reduces, preventive effect increases.After the dispenser 1 day, the preventive effect of each compound drug was all more than 80%, and maximum preventive effect is 93.4% (embodiment 4), is higher than the preventive effect of fenazaquin list agent, explains that compound drug promotes with respect to the agent of fenazaquin list on quick-acting to some extent, has synergistic effect; After the dispenser 7 days, the preventive effect of each compound drug was all more than 85%, and especially the preventive effect of embodiment 4 reaches 98.2%, explained that fenazaquin and butyl ether urea are composite to have an obvious synergistic effect; After the dispenser 21 days, the preventive effect of each compound drug was higher than 70.6% of butyl ether urea list agent all more than 90%, explains that aspect lasting effect, the lasting effect of compound drug is better, and lasting effect is strong, can reduce the whole growth spraying times in season, reduced the control cost.
The result of Toxicity Determination and field efficiency test shows, fenazaquin and butyl ether urea be composite to have synergistic effect, can reduce dosage, reduces and pollutes; Synergistic effect is obvious, and lasting effect strengthens, and can reduce the whole growth spraying times in season, delays the evil mite and develops immunity to drugs, and can reduce the control cost simultaneously, the protection environment.
Claims (4)
1. a miticide composition is characterized in that active ingredient contains fenazaquin and butyl ether urea, and wherein the mass fraction ratio of fenazaquin and butyl ether urea is 20: 1-1: 80.
2. miticide composition according to claim 1, the mass fraction ratio that it is characterized in that active ingredient fenazaquin and butyl ether urea is 10: 1-1: 30.
3. miticide composition according to claim 1 is characterized in that formulation is missible oil, wetting powder, water dispersible granules, suspending agent or microemulsion.
4. be used for the control of cotton tetranychid according to each described miticide composition of claim 1 to 3.
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|---|---|---|---|
| CN 201010004931 CN101731250B (en) | 2010-01-20 | 2010-01-20 | Fenazaquin-containing acaricidal composition |
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|---|---|---|---|
| CN 201010004931 CN101731250B (en) | 2010-01-20 | 2010-01-20 | Fenazaquin-containing acaricidal composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366379A (en) * | 2007-06-29 | 2009-02-18 | 拜尔农作物科学股份公司 | Acaricidal active substance combinations |
| CN101653134A (en) * | 2009-08-03 | 2010-02-24 | 东莞市瑞德丰生物科技有限公司 | Mite-killing composition containing fenazaquin |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366379A (en) * | 2007-06-29 | 2009-02-18 | 拜尔农作物科学股份公司 | Acaricidal active substance combinations |
| CN101653134A (en) * | 2009-08-03 | 2010-02-24 | 东莞市瑞德丰生物科技有限公司 | Mite-killing composition containing fenazaquin |
Non-Patent Citations (3)
| Title |
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| 刘刚.沈阳化工研究院成功研制25%丁醚脲·哒螨灵悬浮剂.《农药市场信息》.2008,(第10期),31. * |
| 周艳丽.新型杀螨剂喹螨醚的合成.《农药科学与管理》.2005,第26卷(第6期),33-34. * |
| 赵玉伟.二斑叶螨和朱砂叶螨对常用杀螨剂的敏感性比较.《农药》.2006,第45卷(第6期),418-419. * |
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