CN101406197B - Compositional mite-killing composition containing spirodiclofen and ivermectin - Google Patents
Compositional mite-killing composition containing spirodiclofen and ivermectin Download PDFInfo
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- CN101406197B CN101406197B CN2008102323276A CN200810232327A CN101406197B CN 101406197 B CN101406197 B CN 101406197B CN 2008102323276 A CN2008102323276 A CN 2008102323276A CN 200810232327 A CN200810232327 A CN 200810232327A CN 101406197 B CN101406197 B CN 101406197B
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- spiral shell
- ivermectin
- mite
- mite ester
- shell mite
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Abstract
The invention belongs to the technical field of pesticides, and in particular relates to an acaricide composition containing spirodiclofen, which comprises a first active component spirodiclofen and a second active component ivermectin, wherein the weight percentage of the spirodiclofen to the ivermectin is between 1 to 0.01 and 1 to 10. The prior auxiliary agents and exipients are added to the acaricide composition to be prepared into wettable powder, water dispersible granules, suspending agents, emulsifiable solution, and micro emulsion for controlling pest mites on fruit trees. The acaricide composition is good to the safety of crops and has obvious synergism.
Description
Technical field
The present invention relates to a kind of complex composition with acaricidal activity, the composite miticide composition with synergistic effect of especially a kind of spiral shell mite ester and Ivermectin HCL belongs to technical field of pesticide.
Background technology
Spiral shell mite ester English name: (spirodiclofen), chemical name is: 3-(2,4 dichlorophenyl)-2-oxygen-1-oxygen spiral shell [4.5] last of the ten Heavenly stems-3-alkene-4-base-2,2-dimethyl butyrate acid esters, molecular formula is: C
21H
24C
12O
4Structural formula is:
Spiral shell mite ester is the miticide of a brand-new mechanism of action developing more than ten years consuming time of Bayer Cropscience Co.,Ltd, and the mechanism of action is destroyed the energy metabolism activity of acarid for suppressing the lipogenesis in the evil mite body, finally kills harmful mite.Its mite mechanism of killing is different from the existing various miticides of thinking fully, so do not have the cross resistance problem with other existing miticides, can be used for preventing and treating multiple resistance tetranychid.
(registration card number: LS20042173), done the demonstration test of 18 points then in the oranges and tangerines district of 8 provinces in south, the result proves that its panonychus citri has outstanding control efficiency to spiral shell mite ester in 2004 in the interim registration of China's acquisition on oranges and tangerines.Spiral shell mite ester began to sell at home in 2005, behind the part oranges and tangerines grower hit and miss experiment spiral shell mite ester, reflected that generally its control efficiency is good, and the lasting period is long.This product have broad spectrum activity, ovum children hold concurrently kill, the lasting period is long, toxicity is low, safety is good and other miticides do not have the characteristics of cross resistance, shortcoming is that speed of action is slower, to becoming the mite effect undesirable.Spiral shell mite ester is applicable to various mite class controls at present, as Tetranychidae, oranges and tangerines cotton spider mites, Tetranychus cinnabarinus etc.
The English name of ivermectin: (ivermectin), chemical name is: 5-O-demethyl-22,23 couple hydrogen Avermectin A1, molecular formula is: C
48H
74O
14, C
47H
72O
14
Structural formula is:
Ivermectin HCL is compared with the parent Avermectin as the structure optimization product of agricultural antibiotic, has not only kept its expelling parasite and acaricidal activity.And safety is higher, be difficult for to produce resistance, for the production of vegetables, fruit, cotton etc. provides efficient a, high security and the good biological source insecticide of Environmental compatibility.
Panonychus citri (having another name called citrus red mite) belongs to Acarina, and Tetranychidae is with young mite, if mite, become mite to suck juice such as blade, spray, young fruit, bud to cause harm; The position elder generation chlorisis of being injured, after present the canescence spot, blade tarnishes, and causes fallen leaves, fallen flowers and shedding, spray is withered.
Go up the harmful mite that produces resistance for control agricultural, a kind of way is to release the new component that new and existing kind do not have cross resistance, still, the development cost height of new composition, the construction cycle is long, is unable to catch up with the speed of harmful mite generation resistance forever.Other method such as crop allocation adjustment, different agricultural chemicals are rotated etc., in the process of practical operation, are difficult to really play obvious effects.
The different cultivars composition carries out composite, is control resistant insect or the very common method of evil mite.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.The present invention just is based on above-mentioned theory research, and the inventor finds that the composite control to the evil mite of above-mentioned two kinds of active components has very outstanding effect, and has effectively slowed down the generation of pest resistance.
Summary of the invention
The purpose of this invention is to provide a kind of miticide composition that contains spiral shell mite ester that is used to prevent and treat the fruit tree acarid.It is very outstanding to be particularly useful for preventing and treating oranges and tangerines evil mite effect.
The present invention is achieved by the following technical solutions:
A kind of Pesticidal combination that contains spiral shell mite ester is characterized in that comprising spiral shell mite ester and Ivermectin HCL, and spiral shell mite ester and Ivermectin HCL weight ratio are 1:0.01～10.
Optimum weight part of spiral shell mite ester and anabasine insecticide is 1 part～80 parts of spiral shell mite esters in the Pesticidal combination that contains spiral shell mite ester of the present invention, 0.01 part～20 parts of Ivermectin HCLs.
The described Pesticidal combination active ingredient total content that contains spiral shell mite ester is 1%～80%.
Said composition adds auxiliary agent and excipients can be made into wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, missible oil.
Described auxiliary agent and excipients comprise: dispersant, wetting agent, disintegrant, solvent, emulsifier, antifreeze, defoamer, thickener, filler.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, DBSA, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described solvent is selected from: N, dinethylformamide, cyclohexanone, toluene, dimethylbenzene, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, 3-methyl cyclohexanol ketenes, N-octylpyrrolidone, N-pyrrolidones, propyl alcohol, butanols, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil, acetonitrile one or more.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), peaceful breast 36
#(phenethyl fluosite polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), farming breast 34
#In (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the AEO series (the pure APEO of fat) one or more.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the urea.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Pesticidal combination of the present invention compared with prior art produces following beneficial effect: (1) is compared with single agent, and said composition has notable synergistic to the evil mite, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests, evil mite simultaneously, reduce control recruitment cost; (3) alternative height agricultural chemicals, and reduce the field dosage significantly, effectively reduce environmental pollution and residue of pesticide; (4) said composition especially has good preventive effect for citrus red mite, the tetranychid that begins to fruit tree resistance evil mite, and to the target crop safety; (5) can adjust two kinds of active substance proportionings according to the serious situation of harmful mite of target crop, can prevent and treat simultaneously other insects evil mites of target crop, as leaf miner etc.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.
By indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, is carrying out field trial earlier.
Application Example one: spiral shell mite ester and Ivermectin HCL different proportion are used with the citrus red mite toxicity test
Reagent agent: spiral shell mite ester and Ivermectin HCL complex preparation (Shaanxi Welch Crop Protection Co., Ltd.'s research and development, production), 240 grams per liter spiral shell mite ester suspending agent (Bayer Cropscience (China) Co., Ltds; commercial), 0.5% Ivermectin HCL missible oil (Zhejiang Hisun Chemical Co., Ltd, commercial).
Each active constituent content of test medicine is designed 5 concentration of treatment respectively, is contrast with the space management, adopts the slide infusion process.Every concentration repeats 3 times, calculates lethality, corrected mortality.Its toxicity test result, virulence regression equation formula, LC
50The co-toxicity coefficient that value and both different proportions are used with sees Table 1
The different proportionings of table 1 spiral shell mite ester, Ivermectin HCL are to the toxicity test of citrus red mite
Find out that by table 1 all greater than 120, the two kinds of medicaments in surface are used with institute's examination ratio has certain synergistic effect to citrus red mite, wherein obvious with the 10:1 synergistic effect to the co-toxicity coefficient of citrus red mite for spiral shell mite ester and Ivermectin HCL.
Application Example two: the composite field control effectiveness test of spiral shell mite ester and Ivermectin HCL
Embodiment 1:30% spiral shell mite ester Ivermectin HCL wetting powder
29g spiral shell mite ester, 1g Ivermectin HCL, 3g lauryl sodium sulfate, 5g alkylnaphthalene sulfonate formaldehyde condensation products, 8g white carbon, kaolin are mended to 100g, above-mentioned formulation material is mixed, in stirred tank, evenly stir, behind airslide disintegrating mill, become 30% spiral shell mite ester Ivermectin HCL wetting powder mixing.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 30%, form new embodiment.
Embodiment 2:35% spiral shell mite ester Ivermectin HCL water dispersible granules
32g spiral shell mite ester, 3g Ivermectin HCL, 4g neopelex, 4g lignin sodium sulphate, 2g alkylnaphthalene sulfonate formaldehyde condensation products, diatomite are mended to 100g, formulation material is mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis becomes 35% spiral shell mite ester Ivermectin HCL water dispersible granules.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 35%, form new embodiment.
Embodiment 3:31.5% spiral shell mite ester Ivermectin HCL suspending agent
30g spiral shell mite ester, 2g Ivermectin HCL, 2g farming breast 1600
#, 4g polycarboxylate, 4g ethylene glycol, 1g polyethylene glycol, 0.4g silicone oil, water is supplied 100g, with back all the other components except that crossing active ingredient in the above-mentioned formulation material, mix through high speed shear, add active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes 31.5% spiral shell mite ester Ivermectin HCL suspending agent.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 31.5%, form new embodiment.
Embodiment 4:20% spiral shell mite ester Ivermectin HCL missible oil
18g spiral shell mite ester, 2g Ivermectin HCL, 5g toluene, 4g farming breast 500
#, 4g farming breast 600
#, the 2g Nongru-700
#, dimethylbenzene is supplied 100g.Above-mentioned formulation material is mixed, former medicine is dissolved in the organic solvent, add other auxiliary agents such as emulsifier again, under agitation mixed dissolution can make 20% spiral shell mite ester Ivermectin HCL missible oil.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 20%, form new embodiment.
Embodiment 5:15% spiral shell mite ester Ivermectin HCL aqueous emulsion
14g spiral shell mite ester, 1g Ivermectin HCL, 15g dimethylbenzene, 5g vegetable oil, 2g farming breast 1600
#, 4g farming breast 500
#, 4g ethylene glycol, 1g polyethylene glycol, 0.4g silicone oil, 100g water is supplied.Above-mentioned formulation material is mixed, active ingredient, solvent, emulsifier, co-emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make 15% spiral shell mite ester Ivermectin HCL aqueous emulsion.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 15%, form new embodiment.
Embodiment 6:6% spiral shell mite ester Ivermectin HCL microemulsion
5g spiral shell mite ester, 1g Ivermectin HCL, 15g dimethylbenzene, 5g vegetable oil, 8g farming breast 1600
#, 7g farming breast 500
#, 4g ethylene glycol, 0.4g silicone oil, water is supplied 100g.The compound method of microemulsion: be that emulsifier and water are mixed and made into water, the former medicine that will be dissolved in then in the solvent under agitation adds water, makes 6% spiral shell mite ester Ivermectin HCL microemulsion.
The part by weight of spiral shell mite ester and Ivermectin HCL can change between 1:0.01～10 (routine 50:10,45:15,1:1,99:1) in the present embodiment, the optimum weight ratio is 1:0.03～0.5, but both total weight items are 6%, form new embodiment.
Handle the chemical control citrus red mite test of pesticide effectiveness
Reagent agent: spiral shell mite ester and Ivermectin HCL complex preparation (Shaanxi Welch Crop Protection Co., Ltd.'s research and development, production), 240 grams per liter spiral shell mite ester suspending agent (Bayer Cropscience (China) Co., Ltds; commercial), 0.5% Ivermectin HCL missible oil (Zhejiang Hisun Chemical Co., Ltd; commercial, 1.8% abamectin emulsifiable concentrate (Guilin Jiqi Biochemical Co., Ltd., commercial).
This experimental establishment is exerted oneself Yang Zhen Jia Qi village, 15 mu of areas, the age of tree 15 years in Mian County, Shaanxi Province.
Control time: carry out the investigation of insect population radix before the dispenser, each is investigated once after 3,7,15 days after the dispenser, record attitude acarid alive number.
Investigation method: the young sprout mark that give birth to then in all directions five positions picked at random of tree every sub-district, the two spotted spider mite quantity of each 20 blade in orientation, hold magnifying glass with hand and directly observe the blade face, blade back two spotted spider mite quantity is calculated insect population go down rate and control efficiency.
Computing formula:
In the formula: CK
0Insect population radix before the medicine of check plot;
CK
1Insect population radix behind the medicine of check plot;
PT
0Insect population radix before the treatment region medicine;
PT
1Insect population radix behind the treatment region medicine.
Experimental result such as table 2
The different proportionings of table 2 spiral shell mite ester Ivermectin HCL are used control citrus red mite effect table with
In experimentation, the present composition is to citrus red mite control efficiency excellence, and its each processing has no adverse effects to oranges and tangerines.And medicament medicament of the present invention has certain preventive effect to phyllocnistis citrella stainton, the tetranychid that begins.Above-mentioned processing medicament does not find that all beneficial organism and target organisms are had harmful effect.
Experiment shows: after spiral shell mite ester and Ivermectin HCL were composite, apparently higher than the contrast pharmacy control efficacy, and dosage was little to the control efficiency of citrus red mite, and quick-acting, lasting effect all are better than contrasting medicament, greatly reduce drug cost.
In sum, the composition that contains spiral shell mite ester of the present invention, obvious to the citrus red mite control efficiency, its activity is compared with single agent with miticidal effect, except that significant acaricidal activity, also have significant synergies, have a medicine and control more, dosage is little, reduce the cost, the generation of delaying drug resistance, to the advantage of target crop and beneficial organism safety.So R﹠D and promotion of the present invention has crucial meaning.
Claims (4)
1. miticide composition, it is characterized in that: the weight ratio of effective ingredient spiral shell mite ester and Ivermectin HCL is 5～30: 1.
2. miticide composition according to claim 1 is characterized in that the active ingredient total content is 1%～80%.
3. miticide composition according to claim 1 and 2 is characterized in that: said composition adds conventional auxiliary agent and excipients and makes wetting powder, water dispersible granules, suspending agent, missible oil, aqueous emulsion, microemulsion.
4. miticide composition according to claim 3 is used to prevent and treat the purposes of citrus red mite.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102239840B (en) * | 2011-07-11 | 2013-03-27 | 北京燕化永乐农药有限公司 | Compound insecticidal and acaricidal agent |
| CN103947655B (en) * | 2014-04-11 | 2015-09-16 | 吴燕妮 | A kind of Pesticidal combination comprising ivermectin and spiral shell mite ester |
| CN104472439B (en) * | 2014-11-24 | 2016-10-19 | 天峨县平昌生态农业有限公司 | A kind of method utilizing wasp preventing and treating phyllocnistis citrella stainton |
| CN104996438A (en) * | 2015-06-24 | 2015-10-28 | 西南大学柑桔研究所 | Miticidal composition |
| CN107318862A (en) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination |
Citations (2)
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| WO2005048712A1 (en) * | 2003-11-14 | 2005-06-02 | Bayer Cropscience Aktiengesellschaft | Active agent combinations with insecticidal and acaricidal properties |
| CN101300979A (en) * | 2008-07-08 | 2008-11-12 | 广西田园生化股份有限公司 | Compounded pesticide composition containing Spirodiclofen |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005048712A1 (en) * | 2003-11-14 | 2005-06-02 | Bayer Cropscience Aktiengesellschaft | Active agent combinations with insecticidal and acaricidal properties |
| CN101300979A (en) * | 2008-07-08 | 2008-11-12 | 广西田园生化股份有限公司 | Compounded pesticide composition containing Spirodiclofen |
Non-Patent Citations (1)
| Title |
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| 刘玉等.螨危24%悬浮剂防治柑橘红蜘蛛的效果及使用技术研究.《湖南农业科学》.2006,(第2期),66-67，76. * |
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