CN103947655B - A kind of Pesticidal combination comprising ivermectin and spiral shell mite ester - Google Patents

A kind of Pesticidal combination comprising ivermectin and spiral shell mite ester Download PDF

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CN103947655B
CN103947655B CN201410145142.7A CN201410145142A CN103947655B CN 103947655 B CN103947655 B CN 103947655B CN 201410145142 A CN201410145142 A CN 201410145142A CN 103947655 B CN103947655 B CN 103947655B
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ivermectin
spiral shell
mite ester
shell mite
composition
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CN103947655A (en
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吴燕妮
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Cheng Jing
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Abstract

The present invention relates to a kind of miticide composition containing ivermectin and spiral shell mite ester.This miticide composition is that two yuan of carrying out for active ingredient with ivermectin and spiral shell mite ester are composite, the mass ratio of described active ingredient ivermectin and spiral shell mite ester is 1: 50-50: 1, the quality of active ingredient ivermectin and spiral shell mite ester accounts for the 1-80% of miticide composition gross mass, and all the other are the auxiliary element allowing in agricultural chemicals to use.The present composition has significant control efficiency to citrus red mite, European red mite, cotton red spider.The present composition has notable synergistic, reduces pesticide dosage, reduce cost accounting, delaying drug resistance occurs and reduces the advantage to the pollution of environment.

Description

A kind of Pesticidal combination comprising ivermectin and spiral shell mite ester
Technical field
The invention belongs to pesticides application technical field, relate to a kind of composition pesticide, specifically a kind of miticide composition containing ivermectin and spiral shell mite ester.
Background technology
Ivermectin, English name Ivermectin (being called for short IVM) is by Avermectin active component B by Merck company of the U.S. 1c 22=C 23first Avermectin analog derivative that double-bond hydrogenation is reduced into saturation state and develops.Comparatively Avermectin is low for the toxicity of ivermectin, and stability is better.At present, relative to Avermectin, ivermectin mainly as veterinary drug use and agriculturally use less.Southwestern University Li Jing etc. compares research to the biologically active of ivermectin and Avermectin, and result of study shows, ivermectin has and good kills mite and eelworm-killing activity.
Spiral shell mite ester, English name Spirodiclofen, is the novel tetronic acid class miticide developed by Beyer Co., Ltd, has the brand-new mechanism of action, tool action of contace poison, do not have interior absorption.Mechanism of action suppresses the Fatty synthesis in pest mite body.Ovicidal effect is excellent especially, if also have good action of contace poison to children mite simultaneously.All have fine preventive effect to two spotted spider mite, yellow spider, Xiu Pi lice, yellow tea mite, Tetranychus cinnabarinus and Tetranychus urticae etc., the mite evil that can be used for the solanaceous crops such as the fruit tree such as citrus, grape and eggplant, capsicum, tomato is administered.With existing miticide without cross resistance, after using with it, both can improve the quick-acting of mite danger, be conducive to again the resistance management of mite evil.
Agricultural Mites, has another name called two spotted spider mite, belongs to arachnids Acarina, is one of primary pest of the crops such as harm fruit tree, cotton, tealeaves, has a strong impact on the growing way of fruit tree and crops.Because the generation of mite class is many, breeding spreads fast, and how generation alternately grows up, and thus control is got up quite difficult.In addition, mite class is different from general agricultural pests physiological mechanism, and common insecticide does not almost have control efficiency to mite class usually.At present, China is less for the specialized acaricide preventing and treating mite class, peasant household uses dicofol, pyridaben, propargite, isocarbophos, azacyclotin and their mixture usually, but these effect of chemical control are not good, thus peasant household all needs to use a large amount of agricultural chemicals every year and prevents and treats mite pest.For a long time, due to indiscriminate use of pesticide, mite pest creates serious resistance to common agricultural chemicals, and causes these effect of chemical control to reduce year by year.Therefore, efficient, low toxicity, non-harmful Pesticidal products are badly in need of in peasant household.
Being carried out by the pesticide active ingredient of the different mechanism of action composite is the one mode effectively efficiently developed pesticide new product at present and prevent and treat resistance damage by disease and insect.Different pesticide active ingredient carry out composite after, three kinds of type of action can be shown: summation action, synergistic effect and antagonism.Usually, only have by a large amount of tests just can learn different pesticide active ingredient composite after type of action.The Recompounded pesticide of screening tool synergistic effect, can significantly improve control efficiency, reduce Pesticide use amount, reduce cost accounting, and can also expanding prevention compose, delaying the generation of damage by disease and insect resistance, is one of important means of current integrated pest prevention and control.
Inventor is tested and field control effectiveness test by a large amount of indoor biometrics, and filter out the miticide composition of ivermectin and spiral shell mite ester, said composition has synergistic effect within the specific limits.Up to now, the miticide composition being active ingredient with ivermectin and spiral shell mite ester, there is not yet relevant report at home and abroad.
Summary of the invention
The present invention is directed to that conventional miticide dosage is large, cost accounting is high, insecticidal spectrum is narrow, resistance produces fast outstanding problem, provide a kind of miticide composition containing ivermectin and spiral shell mite ester, the advantage that said composition tool improves control efficiency, expansion insecticidal spectrum, delaying drug resistance generation, minimizing pesticide dosage and reduces costs.
Technical scheme of the present invention is:
Containing a miticide composition for ivermectin and spiral shell mite ester, this miticide composition is that two yuan of carrying out for active ingredient with ivermectin and spiral shell mite ester are composite, and described ivermectin and spiral shell mite ester mass ratio are: 1: 50-50: 1.
As preferably, in the above miticide composition, the mass ratio of ivermectin and spiral shell mite ester is 1: 30-50: 1.
Preferred as the best, the mass ratio of described ivermectin and spiral shell mite ester is 1: 10.In described acaricide composition ivermectin and spiral shell mite ester quality account for the 1-80% of acaricide composition gross mass.
Also containing pesticidal preparations auxiliary element in described mite and insect killing agent composition, described auxiliary element is made up of one or more in solvent, cosolvent, emulsifier, wetting agent, dispersant, thickener, antifreezing agent, carrier and disintegrant auxiliary element, said composition is made the formulations of pesticide of applicable Pesticide use.
Described solvent is ester class or sulfone class, and described ester class is sec-butyl acetate and ethyl acetate; Sulfone class is dimethyl sulfoxide (DMSO);
Described cosolvent is ketone or higher alcohol, and described ketone is cyclohexanone and N-pyrrolidones; Higher alcohol is n-butanol;
Described emulsifier, wetting agent, dispersant are non-ionic surface active agent or anion surfactant, and described non-ionic surface active agent is castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, styryl phenyl polyoxyethylene poly-oxygen propylene aether, aliphatic alcohol polyethenoxy polyoxypropylene graft copolymer, tristyrylphenyl APEO and calcium dodecyl benzene sulfonate castor oil polyoxyethylene ether; Anion surfactant is calcium dodecyl benzene sulfonate, sodium lignin sulfonate lauryl sodium sulfate, thermally coupled distillation columns and aliphatic alcohol polyoxyvinethene phosphate ammonium salt;
Described thickener is xanthans, gum Arabic, Magnesiumaluminumsilicate and polyvinyl alcohol;
Described antifreezing agent is polyalcohol, and described polyalcohol is ethylene glycol, glycerine and propane diols;
Described carrier is white carbon, kaolin or diatomite;
Described disintegrant is ammonium sulfate, sodium chloride or ammonium sulfate.
Described mite and insect killing agent composition, can adopt method well known in the art to be prepared into the formulations of pesticide of applicable agricultural use.As preferably, aqueous emulsion, microemulsion, suspending agent, wetting powder or water dispersible granules can be prepared into.
Described insecticidal/acaricidal composition, has good control efficiency to Agricultural Mites such as citrus red mite, European red mite and cotton red spiders.
The invention has the beneficial effects as follows:
1, two kinds of active ingredients composite after, there is obvious synergistic effect, improve control efficiency.
2, between two kinds of active ingredients without cross resistance, thus composite rear use can the producing and developing of delaying drug resistance.
3, decrease the usage amount of agricultural chemicals, reduce cost accounting, decrease environmental pollution, alleviate the pressure to environment.
Embodiment
The following specific embodiment of the present invention is described in detail its beneficial effect.
One, indoor virulence test measures
1. experiment material: test medicine adopts 95% ivermectin and the former medicine of 95% spiral shell mite ester; Examination worm is the cotton tetranychid adopted from field, if the first generation mite hatched through indoor steamed bun breeding.
2. test method: adopted leaf butterfly spray-on process, each single dose and Mixed Pharmacy arrange 5 different concentration (on the basis of preliminary experiment result, if cotton tetranychid mite lethality sets by geometric progression in the scope of 5%-90%), often 3 repetitions are established in process, make blank with clear water.
3. operating procedure: first get the cotton leaf that growth is consistent, leaf butterfly is made with card punch, a wet sponge block is placed in culture dish, it puts filter paper, foliation butterfly on filter paper, every ware puts 3 pieces of leaf butterflies, select indoor feeding, healthy, that the length of time is consistent cotton tetranychid nymph is inoculated on leaf butterfly, every leaf butterfly inoculates 20.
Under the culture dish being connected to leaf butterfly is placed in potter spray tower, spray under 50PSI pressure, spray amount is 1ml, takes out culture dish after sedimentation 1min, and then the culture dish processed is put into 12H/12H lighting box and cultivate, 48h checks dead borer population, calculates lethality.Often 3 repetitions are established in process, make blank with clear water.
4. computational methods: analyze test data with DPS statistical analysis software, calculate the LC50 of each medicament, evaluate the insecticidal activity of each medicament.And the co-toxicity coefficient (CTC value) of mixture is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC50/ reagent agent LC50) × 100.
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
According to the NY/T1154.13-2008 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
5. result of the test: refer to table 1-3.
If table 1 ivermectin and spiral shell mite ester are to the indoor joint toxicity measuring of citrus red mite mite
If table 2 ivermectin and spiral shell mite ester are to the indoor joint toxicity measuring of European red mite mite
If table 3 ivermectin and spiral shell mite ester are to the indoor joint toxicity measuring of cotton red spider mite
Toxicity Determination result shows: in said composition, the mass ratio of ivermectin and spiral shell mite ester is in 1: 50-50: 1 scope, co-toxicity coefficient is all greater than 120, and namely the biologically active of said composition to citrus red mite, European red mite and cotton red spider all shows as synergistic effect; Especially the mass ratio of ivermectin and spiral shell mite ester is in 1: 30-50: 1 scope, and co-toxicity coefficient is all more than 130, and synergistic effect is more obvious; Particularly when the mass ratio of ivermectin and spiral shell mite ester is 1: 10, synergistic effect is the most obvious.
Two, embodiment prepared by agricultural chemicals
1, the preparation of aqueous emulsion
Embodiment 1:1% ivermectin spirodiclofen water emulsion
Embodiment 2:10% ivermectin spirodiclofen water emulsion
Embodiment 3:15% ivermectin spirodiclofen water emulsion
The preparation method of the above aqueous emulsion is: after active ingredient ivermectin and spiral shell mite ester solvent, cosolvent fully being dissolved, and input emulsifier, dispersant, wetting agent form oil phase after fully stirring; Antifreezing agent is added to the water dissolving, forms aqueous phase; Aqueous phase is slowly added in oil phase, use high-speed shearing machine shear, aqueous emulsion.
3, the preparation of microemulsion
Embodiment 4:5% ivermectin spirodiclofen microemulsion
Embodiment 5:8% ivermectin spirodiclofen microemulsion
Embodiment 6:15% ivermectin spirodiclofen microemulsion
The preparation method of the above microemulsion is: after active component ivermectin and spiral shell mite ester solvent, cosolvent fully being dissolved, and drops into emulsifier, forms oil phase after fully stirring; Antifreezing agent is added to the water and obtains aqueous phase; Aqueous phase is slowly added in oil phase, uses high-speed shearing machine to shear, transparent microemulsion.
3, the preparation of suspending agent
Embodiment 7:20% ivermectin spiral shell mite ester suspending agent
Embodiment 8:30% ivermectin spiral shell mite ester suspending agent
Embodiment 9:50% ivermectin spiral shell mite ester suspending agent
The preparation method of the above suspending agent is: after using airslide disintegrating mill to pulverize active component ivermectin and spiral shell mite ester, drop in stirred tank, drop into dispersant, wetting agent, antifreezing agent and water simultaneously, after abundant stirring, fully grind in material suction sand mill, after having ground, in suction high-speed shearing machine, after adding thickener, carry out high speed shear, after having sheared, namely obtain suspending agent.
4, the preparation of wetting powder
Embodiment 10:50% ivermectin spiral shell mite ester wetting powder
Embodiment 11:60% ivermectin spiral shell mite ester wetting powder
Embodiment 12:80% ivermectin spiral shell mite ester wetting powder
The preparation method of the above wetting powder is: by formula rate, active ingredient and preparation auxiliary element is mixed, and pulverizes, then mix through airslide disintegrating mill, i.e. obtained wetting powder.
The preparation of 5, aqueous dispersion granular agent
Embodiment 13:25% ivermectin spirodiclofen water dispersible granule
Embodiment 14:50% ivermectin spirodiclofen water dispersible granule
Embodiment 15:70% ivermectin spirodiclofen water dispersible granule
The preparation method of above water dispersible granules is: by formula rate, after active ingredient and preparation auxiliary element being mixed, pulverizes through airslide disintegrating mill, again mix, then, add a certain amount of water and this mixture is mediated, extruder grain, drying is sieved, and namely obtains water dispersible granules.
The foregoing is only preferred embodiment of the present invention, and be not used to the scope limiting substantial technological content of the present invention, substantial technological content of the present invention is broadly defined in the right of application, any technology that other people complete or method, if with the right of the application define identical, or the replacement of just a kind of equivalence, is all regarded as being covered by among this right.

Claims (3)

1. one kind containing ivermectin and spiral shell mite ester composition for preventing and treating the purposes of European red mite and cotton red spider, it is characterized in that: this miticide composition is that two yuan of carrying out for active ingredient with ivermectin and spiral shell mite ester are composite, the mass ratio of described ivermectin and spiral shell mite ester is 3:1-50:1, the quality of active ingredient ivermectin and spiral shell mite ester accounts for the 20-80% of miticide composition gross mass, and all the other auxiliary elements are: one or more in aliphatic alcohol polyoxyvinethene phosphate ammonium salt, polyoxyethylene nonylphenol ether, aluminium-magnesium silicate, xanthans, ethylene glycol and water.
2. as claimed in claim 1 containing ivermectin and spiral shell mite ester composition for preventing and treating the purposes of European red mite and cotton red spider, it is characterized in that: described active ingredient ivermectin and spiral shell mite ester mass ratio be: 3:1.
3. as claimed in claim 1 containing ivermectin and spiral shell mite ester composition for preventing and treating the purposes of European red mite and cotton red spider, it is characterized in that: described composition is prepared into aqueous emulsion, microemulsion, suspending agent, wetting powder or water dispersible granules.
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CN104542594A (en) * 2014-12-15 2015-04-29 广西大学 Mite-killing composition containing pleocidin and spirodiclofen
CN107318862A (en) * 2016-04-28 2017-11-07 江苏龙灯化学有限公司 A kind of Pesticidal combination
CN107318859A (en) * 2016-04-28 2017-11-07 江苏龙灯化学有限公司 A kind of Pesticidal combination
CN107517984A (en) * 2016-06-21 2017-12-29 江苏龙灯化学有限公司 A kind of Pesticidal combination

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Address after: 536000 Jilin Beihai Road, Taiwan Road, Northeast China Electronics Beihai Industrial Park incubator building, room, 3rd floor, Room 302

Patentee after: Wu Yanni

Address before: 532200 the Guangxi Zhuang Autonomous Region Chongzuo Jiangzhou District No. 22 Jianshe Road

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