CN104522000A - Acaricidal composition containing cyflumetofen and ivermectin - Google Patents
Acaricidal composition containing cyflumetofen and ivermectin Download PDFInfo
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- CN104522000A CN104522000A CN201410823043.XA CN201410823043A CN104522000A CN 104522000 A CN104522000 A CN 104522000A CN 201410823043 A CN201410823043 A CN 201410823043A CN 104522000 A CN104522000 A CN 104522000A
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- cyflumetofen
- ivermectin hcl
- ivermectin
- mite
- composition containing
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Abstract
The invention discloses an acaricidal composition containing cyflumetofen and ivermectin. The acaricidal composition comprises the cyflumetofen, the ivermectin and pesticide auxiliaries, wherein the weight ratio of the cyflumetofen to the ivermectin is (20 to 1)-(1 to 20); and the sum of the weight of the cyflumetofen and the ivermectin accounts for 5-85% of the weight of the composition. According to actual application requirements, the acaricidal composition disclosed by the invention can be prepared into any one of suspending agents, water dispersible granules, emulsion in water, microemulsion and wettable powder and is used for controlling agricultural mites.
Description
Technical field
The present invention relates to a kind of miticide composition containing cyflumetofen and Ivermectin HCL, is with cyflumetofen and Ivermectin HCL for active ingredient, for preventing and treating panonychus citri and cotton Tetranychus urticae.
Background technology
Cyflumetofen; english common name: Cyflumetofen; it is novel acyl acetonitrile class contact killing type miticide; the respiration of mite chondrioid can be suppressed; mite is better than into young mite effect; with the miticide used at present without cross resistance, be mainly used in preventing and treating panonychus citri, also efficient to cotton safflower Tetranychus urticae.
Ivermectin HCL, english common name: Ivermectin, the mechanism of action of Ivermectin HCL is mainly combined with the high-affinity being the chloride channel of valve without spinal animals nerve cell and muscle cell Glutamic Acid, thus cause cell membrane to the increase of chlorion permeability, cause nerve cell or muscle cell hyperpolarization, insect is benumbed or death, agriculturally can be used for the pest such as water prevention rice borer, vegetables diamond-back moth, fruit tree mites.
Mite class is the common insect of a class, and the crops such as agriculturally common harmful mite main harm beans, gourd, fruit and vegetable, fruit tree and cotton, often cause destructive disaster to crop.Evil mite occurs from generation to generation many, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity increases rapidly in the short period of time exponentially, thus easily develops immunity to drugs to miticide, causes serious harm to crop simultaneously.
Different pesticide species composition carries out composite, is the common methods of control agriculture resistant insect evil mite.The present inventor is on the basis of a large amount of indoor virulences and field medicine effect test, the compounded formula screening of cyflumetofen and Ivermectin HCL is conducted in-depth research, find that cyflumetofen and Ivermectin HCL carry out composite, in certain proportion, there is obvious synergistic function, and to panonychus citri, cotton Tetranychus urticae, there is outstanding control efficiency, after further study, the present invention is completed.
Technical scheme
The technical problem that the present invention solves be to provide a kind of efficient, low toxicity and the lasting period long, effectively can prevent and treat a kind of miticide composition containing cyflumetofen and Ivermectin HCL of Agricultural Mites.
For solving the problem, the technical solution adopted in the present invention is: a kind of miticide composition containing cyflumetofen and Ivermectin HCL, active ingredient is cyflumetofen and Ivermectin HCL, the weight ratio of cyflumetofen and Ivermectin HCL is 20:1 ~ 1:20, cyflumetofen and Ivermectin HCL weight summation in the composition percentage by weight are 5 ~ 85%, and all the other are agriculturally acceptable auxiliary agent.
Miticide composition of the present invention is prepared into any one formulation being applicable to agriculturally using by known method, reasonable formulation has suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wetting powder, the processing technology of various preparation is prior art, can change to some extent according to different situations.
The auxiliary agent used in miticide composition provided by the invention comprises solvent, emulsifier, wetting agent, stabilizing agent, dispersant, safener, thickener, pH adjusting agent, defoamer, antifreezing agent, deionized water, filler etc., all various auxiliary agents conventional in Pesticide formulation, concrete composition and consumption, according to recipe requirements, are determined through simple test.
The production technology of the various application forms of miticide composition provided by the invention all belongs to existing known technology, does not repeat them here.
Miticide composition provided by the invention, adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
Miticide composition provided by the invention for preventing and treating harmful mite agriculturally, especially panonychus citri and cotton Tetranychus urticae.
Miticide composition provided by the invention, usually adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
The present invention has following beneficial effect:
1, miticide composition provided by the invention shows obvious synergistic effect in certain ratio range, and the control efficiency of composition is significantly improved than single dose, reduces the using dosage of agricultural chemicals, decreases the impact of agricultural chemicals on environment, reduces drug cost.
2, the active ingredient mechanism of action of miticide composition provided by the invention is different, and the application of composition can delay or overcome the drug-fast generation of harmful mite, increases the service life, and is conducive to the comprehensive regulation of evil mite.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Preparation method embodiment 1:11% cyflumetofen Ivermectin HCL wetting powder.
Mix entering in blender after above-mentioned material in proportion coarse crushing, more namely obtain 11% cyflumetofen Ivermectin HCL wetting powder after air-flow crushing.
Preparation method embodiment 2:21% cyflumetofen Ivermectin HCL water dispersible granules.
By above-mentioned formula, 21% cyflumetofen Ivermectin HCL water dispersible granules is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
Preparation method embodiment 3:11% cyflumetofen Ivermectin HCL suspending agent.
Above-mentioned material is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 11% cyflumetofen Ivermectin HCL suspending agent of allotment after high shear mixing.
Preparation method embodiment 4:10.5% cyflumetofen Ivermectin HCL aqueous emulsion.
Above-mentioned raw materials is pulverized rear mixing in proportion, through high speed shear emulsification i.e. obtained 10.5% cyflumetofen Ivermectin HCL aqueous emulsion.
Preparation method embodiment 5:10% cyflumetofen Ivermectin HCL microemulsion.
Above-mentioned raw materials is pulverized rear mixing in proportion, after abundant stirring and dissolving, complements to 100% by deionized water, continue to be stirred to transparent, be i.e. obtained 10% cyflumetofen Ivermectin HCL microemulsion.
Assays Example 1: cyflumetofen and Ivermectin HCL are to panonychus citri, the indoor joint toxicity measuring of cotton Tetranychus urticae
Test medicine adopts the former medicine of 97% cyflumetofen and the former medicine of 95% Ivermectin HCL.
If if examination worm is through the panonychus citri mite in indoor feeding 3 generation and cotton Tetranychus urticae mite from citrus orchard, cotton plantation collection.
Test method employing leaf butterfly spray-on process (with reference to " NY/T 1154.13-2008 farm-chemical indoor determination test rule insecticide. the 13rd part: leaf butterfly spray-on process ").Concrete operation method is as follows:
Each single dose and Mixed Pharmacy are arranged 5 different concentration gradients (on the basis of preliminary experiment result, if if panonychus citri mite, cotton Tetranychus urticae mite lethality in the scope of 5% ~ 90% by geometric progression setting).
Choose Citrus leaf, cotton leaf that growth is consistent, leaf butterfly is made with card punch, a wet sponge block is placed in culture dish, it puts filter paper, foliation butterfly on filter paper, every ware puts 2 pieces of leaf butterflies, if if select healthy, that Individual Size is consistent panonychus citri mite, cotton Tetranychus urticae mite is inoculated on leaf butterfly, every leaf butterfly inoculates 20.
Under the culture dish being connected to leaf butterfly is placed in potter spray tower, spray under 50PSI pressure, spray amount is 1mL, culture dish is taken out after sedimentation 1min, then the culture dish processed is put into 12H/12H illumination box to cultivate, 48h checks dead mite number, calculates lethality.Often 4 repetitions are established in process, and establish the process of clear water blank.
Statistical analysis is carried out, by calculating the LC of each medicament with DPS statistical analysis software
50evaluate the acaricidal activity of each medicament, and calculate the co-toxicity coefficient (CTC value) of mixture according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC
50/ reagent agent LC
50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
As can be seen from Table 1 and Table 2, cyflumetofen and Ivermectin HCL composite in the scope of 20:1 ~ 1:20 time, co-toxicity coefficient (CTC) is all greater than 140, if if all show unexpected synergistic function to panonychus citri mite, cotton Tetranychus urticae mite, visible cyflumetofen and Ivermectin HCL is composite has reasonability and feasibility.
If table 1, cyflumetofen and Ivermectin HCL are to the indoor joint toxicity measuring result of panonychus citri mite
If table 2, cyflumetofen and Ivermectin HCL are to the indoor joint toxicity measuring result of cotton Tetranychus urticae mite
Assays Example 2: cyflumetofen and the composite field control effectiveness test to panonychus citri of Ivermectin HCL.
Investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d, 30d investigate residual mite number of living respectively, and 2 strains are looked in investigation Shi Mei community, and every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, and every community looks into 40 blades altogether, record mite number of living, and calculate control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine;
Table 3, cyflumetofen and Ivermectin HCL mixture prevent and treat the result of the test of panonychus citri
All to use apparently higher than the cyflumetofen suspending agent single dose same period 20% preventive effect of panonychus citri after cyflumetofen and Ivermectin HCL composite 3d, 7d, 14d, 30d as can be seen from Table 3 and 0.5% Ivermectin HCL missible oil single dose uses, can improve panonychus citri preventive effect compared with illustrating that cyflumetofen and Ivermectin HCL are composite and being used alone with two kinds of single doses, after medicine, 30d preventive effect still reaches more than 90% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to oranges and tangerines.
Assays Example 3: cyflumetofen and the composite field control effectiveness test to cotton Tetranychus urticae of Ivermectin HCL
Investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d, 30d investigate residual mite number of living respectively, and 2 strains are looked in investigation Shi Mei community, and every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, and each community looks into 40 blades altogether, record mite number of living, and calculate control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine;
Table 4, cyflumetofen and Ivermectin HCL mixture prevent and treat cotton Tetranychus urticae result of the test
As can be seen from Table 4 cyflumetofen and Ivermectin HCL is composite use 3d, 7d, 14d, 30d after all to use apparently higher than the cyflumetofen suspending agent single dose same period 20% preventive effect of cotton Tetranychus urticae and 0.5% Ivermectin HCL missible oil single dose uses, can improve cotton Tetranychus urticae preventive effect compared with illustrating that cyflumetofen and Ivermectin HCL are composite and being used alone with two kinds of single doses, after medicine, 30d preventive effect still reaches more than 90% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to cotton.
Assays Example 4: the pesticide resistance indoor measurement of panonychus citri to cyflumetofen and Ivermectin HCL is tested
Cyflumetofen, the former medicine of Ivermectin HCL are mixed with the test medicine needed for test.Worm source gathers from Zhaoqing City of Guangdong Province citrus orchard.Test adopts infusion process, and the concentration that test medicine adopts is the 50%-80% lethal dose of panonychus citri, impregnated in treatment fluid by examination worm, rejects dead examination worm after 48 hours, and the examination worm stayed continues at indoor feeding, so repeatedly processes 20 generations examination worm.If the liquid only containing auxiliary agent is treated to blank.Measure each medicament tries worm half lethal concentration LC to 1st generation, the 10th generation and the 20th generation
50, by contrasting the LC of each treatment agent to the 10th generation, the 20th generation examination worm
50evaluate examination worm to change the pesticide resistance of reagent agent.
Can find out according to table 5, after cyflumetofen and Ivermectin HCL complex preparation process 20 generation examination worm, the examination pesticide resistance of worm population to this compound auxiliary is starkly lower than cyflumetofen and Ivermectin HCL single dose process 20 generation examination worm develops immunity to drugs.This test shows, cyflumetofen and Ivermectin HCL is composite can effectively delay panonychus citri and develop immunity to drugs.
Table 5, cyflumetofen and Ivermectin HCL are composite to the drug-fast determination test result of panonychus citri
Note: above table medium multiple represents that corresponding algebraically Panonychus citri is to the pesticide resistance of each medicament.
In sum, the present invention adopts two kinds of active components to be the complex composition of cyflumetofen and Ivermectin HCL, compared with existing unitary agent, not only there is obvious synergistic effect, also have good miticidal effect, the lasting period is long, to Crop securify, the drug-fast generation of harmful mite can be slowed down, be worth applying in agricultural production.
Claims (4)
1. one kind contains the miticide composition of cyflumetofen and Ivermectin HCL, it is characterized in that: active ingredient is cyflumetofen and Ivermectin HCL, the weight ratio of cyflumetofen and Ivermectin HCL is 20:1 ~ 1:20, and cyflumetofen and Ivermectin HCL weight summation in the composition percentage by weight are 5% ~ 85%.
2. a kind of miticide composition containing cyflumetofen and Ivermectin HCL according to claim 1, is characterized in that: the one that can be prepared as suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wetting powder when practical application.
3. a kind of miticide composition containing cyflumetofen and Ivermectin HCL according to claim 1, is characterized in that: for preventing and treating Agricultural Mites.
4. a kind of miticide composition containing cyflumetofen and Ivermectin HCL according to claim 3, is characterized in that: described Agricultural Mites is panonychus citri and cotton Tetranychus urticae.
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| CN201410823043.XA CN104522000B (en) | 2014-12-23 | 2014-12-23 | A kind of miticide composition containing cyflumetofen and ivermectin |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104542647A (en) * | 2015-01-27 | 2015-04-29 | 西南大学 | Mite killing composition containing ivermectin and cyflumetofen |
| CN104996438A (en) * | 2015-06-24 | 2015-10-28 | 西南大学柑桔研究所 | Miticidal composition |
| CN107087625A (en) * | 2017-05-03 | 2017-08-25 | 广西南宁益土生物科技有限责任公司 | A kind of miticide composition containing cyflumetofen and matrine |
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|---|---|---|---|---|
| JP2009209124A (en) * | 2008-02-06 | 2009-09-17 | Nissan Chem Ind Ltd | Insect- or acarian-controlling composition |
| CN102164491A (en) * | 2008-08-18 | 2011-08-24 | 先正达参股股份有限公司 | Insecticidal combinations comprising abamectin and cyflumetofen |
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2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009209124A (en) * | 2008-02-06 | 2009-09-17 | Nissan Chem Ind Ltd | Insect- or acarian-controlling composition |
| CN102164491A (en) * | 2008-08-18 | 2011-08-24 | 先正达参股股份有限公司 | Insecticidal combinations comprising abamectin and cyflumetofen |
Non-Patent Citations (1)
| Title |
|---|
| 李靖 等: "伊维菌素和阿维菌素的生物活性比较", 《粮食安全与植保科技创新》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104542647A (en) * | 2015-01-27 | 2015-04-29 | 西南大学 | Mite killing composition containing ivermectin and cyflumetofen |
| CN104996438A (en) * | 2015-06-24 | 2015-10-28 | 西南大学柑桔研究所 | Miticidal composition |
| CN107087625A (en) * | 2017-05-03 | 2017-08-25 | 广西南宁益土生物科技有限责任公司 | A kind of miticide composition containing cyflumetofen and matrine |
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| Publication number | Publication date |
|---|---|
| CN104522000B (en) | 2018-02-06 |
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