CN104996438A - Miticidal composition - Google Patents
Miticidal composition Download PDFInfo
- Publication number
- CN104996438A CN104996438A CN201510349982.XA CN201510349982A CN104996438A CN 104996438 A CN104996438 A CN 104996438A CN 201510349982 A CN201510349982 A CN 201510349982A CN 104996438 A CN104996438 A CN 104996438A
- Authority
- CN
- China
- Prior art keywords
- miticide
- composition
- ivermectin
- mite
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a miticidal composition. The miticidal composition is characterized by comprising the following components: ivermectin and etoxazole. According to the invention, the compound composition of ivermectin and etoxazole is screened out through considerable indoor research; ivermectin and etoxazole have different mechanisms of action and exert good synergistic effect when compounded to a certain extent, thereby reducing the utilization amount of pesticide, decreasing residual quantity of pesticide on crops and mitigating environmental pollution; and the composition is safe to human beings and poultry, has good compatibility with the environment and enables pest mites hardly to develop pesticide resistance.
Description
Technical field
The invention belongs to composition pesticide field, be specifically related to a kind of miticide composition.
Background technology
Ivermectin, English name Ivermectin (being called for short IVM) is first the Avermectins medicine derivative by Merck company of the U.S., the double-bond hydrogenation between C22 and the C23 of Avermectin active component B1 being reduced into saturation state and developing.As the structure optimization product of agricultural antibiotic, with current compared with the homologue Avermectin of agriculturally extensive use, ivermectin not only remains its expelling parasite and acaricidal activity, and safety is higher, and stability is better, not easily produces resistance.Southwestern University Li Jing etc. compares research to the biologically active of ivermectin and Avermectin, and result of study shows, ivermectin has and good kills mite and eelworm-killing activity.Current ivermectin mainly as veterinary drug use and agriculturally use less.
Second mite azoles: second mite azoles (etoxazole) chemical name is (RS)-2-(2,6-difluorophenyl)-4-(2-ethyoxyl-4-tert-butyl-phenyl)-4,5-dihydro-1,3-oxazole woods, that SUMITOMO CHEMICAL commercial firm is in the mid-80 exploitation of 20th century and in 1998 commercial 2,4-diphenyl-1,3-oxazole woods class insecticidal/acaricidal agent.Former medicine outward appearance is white tasteless crystal powder, molten some 101.5-102.5 DEG C, proportion 1.2389/m
3, vapour pressure (25 DEG C) 7 × 10
-6pa, solvability (g/L, 205 DEG C) water 7.4 × 10
-5, acetone 309, ethyl acetate 249, normal heptane 18.7, methyl alcohol 104, dimethylbenzene 252.Belonging to 2,4-bis-Jia Ben oxazole derivatives compounds, is a kind of selectivity miticide.Mainly suppress the molting process of mite class, thus have excellence contact from ovum, larva to pupa different phase to mite.But not fine to the control efficiency of adult.Mite class Hexythiazox having been produced to resistance has good control efficiency.Second mite azoles to the tetranychid of the crops such as citrus, the beginning tetranychid and from young mite to the molting process becoming mite, to ovum and young mite effective, invalid to one-tenth mite.
Panonychus citri is a kind of important Agricultural Mites, is one of the most serious arthropods of resistance problems, the various crop such as serious harm oranges and tangerines, apple.China widely distributed and be difficult to again control.Above long-term to continue owing to producing, not science large area use chemical pesticide control, panonychus citri has been caused to produce more and more serious resistance to Multiple Pesticides, control efficiency is caused to reduce year by year, development of drug resistance is rapid, the supply of effective agent is made to seem all the more short, investment and the risk of adding new varieties of pesticides research and production are increasing, and the cycle of the market development is more and more longer, are therefore badly in need of the Pesticidal products of more efficient, safety, environmental protection.
Summary of the invention
The shortcoming of prior art in view of the above, the object of the present invention is to provide a kind of miticide composition, and it can prevent and treat the multiple harmful mite of crops, and what further can also strengthen ovum and mite doublely controls effect, delaying drug resistance, prolongation acaricidal service time.
In order to reach foregoing invention object and other objects, the present invention is achieved by the following technical solutions:
The invention discloses a kind of miticide composition, the material composition of described miticide composition is ivermectin and second mite azoles.
Preferably, the mass ratio of described ivermectin and second mite azoles is 1:10 ~ 10:1.
More preferably, the mass ratio of described ivermectin and second mite azoles is 1:4 ~ 3:2.
More preferably, the mass ratio of described ivermectin and described second mite azoles is 1:4 ~ 3:7, or the mass ratio of described ivermectin and described second mite azoles is 1:1.
The invention also discloses a kind of miticide, described miticide comprise as arbitrary in claim 1 ~ 2 as described in miticide composition.
Preferably, in described acaricidal gross mass for benchmark, the mass fraction of described miticide composition is 1 ~ 50wt%.
More preferably, in the gross mass of described miticide composition for benchmark, the quality of described active ingredient accounts for 5 ~ 50wt% of described miticide composition gross mass.
More preferably, in the gross mass of described miticide composition for benchmark, the quality of described active ingredient accounts for 5 ~ 6wt% of described miticide composition gross mass.
Preferably, described miticide is the one in missible oil, aqueous emulsion, suspending agent, microemulsion or water dispersible granules.
Preferably, described miticide comprise be selected from solvent, surfactant, carrier, antifreezing agent, stabilizing agent, thickener, preservative and disintegrant one or more.
Preferably, described carrier is diatomite.
Preferably, described disintegrant is N, N dimethyl pyrrolidone.
Preferably, described solvent is selected from solvent naphtha S-150#, dimethylbenzene, dimethyl sulfoxide (DMSO), cyclohexanone, N, one or more in N dimethyl pyrrolidone, DMF, methyl alcohol, ethanol, biodiesel, monoethanolamine, isopropylamine, methyl oleate, ethyl acetate, ethylene glycol monomethyl ether, butyl ether and water.
Preferably, described surfactant is non-ionic surface active agent or anion surfactant.
More preferably, described surfactant is selected from one or more in agriculture breast 500#, agriculture breast 603#, agriculture breast 0203B, agriculture breast 601#, agriculture breast BY-120#, lauryl sodium sulfate and calcium dodecyl benzene sulfonate.
More preferably, described stabilizing agent is selected from BHT.BHT is antioxidant 264.
More preferably, described preservative is selected from Sodium Benzoate.
More preferably, described thickener is selected from one or both in aluminium-magnesium silicate and xanthans.
More preferably, described defoamer is selected from organosilicon breast.
The invention also discloses the purposes of a kind of miticide as described above on the mite pest preventing and treating vegetables and fruit.
The present invention is by a large amount of desk research, filter out the complex composition of ivermectin and second mite azoles, ivermectin is different from the mechanism of action of second mite azoles, mutually composite have good synergistic effect within the specific limits, decrease the dosage of agricultural chemicals, reduce the residual quantity of agricultural chemicals on crop, decrease environmental pollution; Person poultry safety, good, the harmful mite of Environmental compatibility are not easily developed immunity to drugs.
Embodiment
Below by way of specific instantiation, embodiments of the present invention are described, those skilled in the art the content disclosed by this specification can understand other advantages of the present invention and effect easily.The present invention can also be implemented or be applied by embodiments different in addition, and the every details in this specification also can based on different viewpoints and application, carries out various modification or change not deviating under spirit of the present invention.
In the present embodiment, worm source is panonychus citri sensitive strain; strain obtained for many years has been raised with potted plant cowpea seedling; raise in plant protection institute of Southwestern University insectary, in illumination box (temperature 26 soil 1 DEG C, relative moisture 60%-80%, illumination L:D=14:10h).
The Toxicity Determination method of single dose:
Adopt medicine embrane method, take former medicine, be configured to series concentration gradient with acetone, by the solution configured, get 1.5-2.0ml respectively and inject the centrifuge tube (mark drug concentration, mite) marked.Blank adopts acetone.Centrifuge tube is put upside down jolting more than 30 times, make medicament be evenly distributed on tube wall.Pour out liquid, centrifuge tube is placed in suction in ventilating kitchen and spends the night.Picking leaf butterfly is upper to be raised, and individuality is comparatively large, and the female one-tenth mite of dynamic and homogeneous 3-5 age in days is in the centrifuge tube handled well, centrifuge tube is collected in porcelain dish, be placed on 24h in constant incubator, take out the centrifuge tube of 24h in constant incubator, the mite of the inside is poured on a clean blank sheet of paper.Observe mite, statistics death toll and survival number.Observation process is carried out under anatomical lens, touches polypide with writing brush, with completely motionless or only have a foot to be death dynamic.Carry out data processing with PoloPlus software, try to achieve virulence regression equation and lethal concentration of 50 LC
50.
The joint toxicity measuring method of different ratio
According to the toxicity test result of single dose, 5 proportionings are selected when evaluating the synergistic effect of ivermectin and second mite azoles mixture by common malicious factorization method, these 5 proportionings are six Along ents of summation action line in isoboles, can be expressed as a/5b, a/2b, a/b, 2a/b, 5a/b.The concentration of these 5 proportioning mixtures is respectively (a+5b)/6, (a+2b)/3, (a+b)/2, (2a+b)/3, (5a+b)/6.Concrete compound method will be for becoming lethal concentration of 50 liquid for examination single dose mother liquor acetone diluted, then 1:5,1:2,1:1,2:1,5:1 mix and obtain different ratio mixture liquid in mass ratio.When the common malicious factor >=20 indicate synergistic effect ,≤-20 indicate antagonism, and-20< altogether malicious factor <20 is expressed as summation action.Computing formula is as follows:
The malicious factor=100 altogether × (mixture observes the theoretical lethality of lethality-mixture) theoretical lethality of/mixture
According to toxicity test result and the common malicious factorization method measurement result of single dose, ivermectin: second mite azoles mass ratio is respectively 1:4,1:2,3:7,2:3,1:1,3:2,4:1.Adopt medicine embrane method to carry out Toxicity Determination, calculate LC
50, and press abundant method calculating co-toxicity coefficient (CTC) of Sun Yun.Co-toxicity coefficient CTC, if confection is M, each single dose of composition M is A, B.Toxicity index TI, active ingredient percentage composition is P, and co-toxicity coefficient method computing formula is as follows:
Toxicity index (TI)=(acaricidal LC of standard
50/ for the acaricidal LC of examination
50) × 100
AT1=(the acaricidal LC of standard of M
50the LC of/M
50) × 100
TT1=T1A × PA+T1B × the PB of M
The CTC=(TTI of the AT1/M of M) × 100 of M
ATI---is actual records mixed toxicity index
The toxicity index that TTI---theory is mixed
The co-toxicity coefficient of CTC---built agent
Together, whether synergy is determined by CTC (co-toxicity coefficient) value two kinds of medicament mixtures, and CTC≤80 are antagonism, and 80<CTC<120 is summation action, and CTC≤120 are synergistic effect.
Result of the test
Table one, altogether malicious factor toxicity test result:
Table two, co-toxicity coefficient toxicity test result:
Can be obtained by the data of table one, ivermectin and the effect of second mite azoles compound synergic obvious.Composite feasibility is high, can be found out by table two data: ivermectin: during second mite azoles=1:2,3:7,1:1, co-toxicity coefficient is apparently higher than 170, there is notable synergistic effect, especially during 1:2 and 1:1, co-toxicity coefficient value up to 245.01 and 265.66, prove ivermectin provided by the invention and second mite azoles composite to evil mite have good preventive effect.
Embodiment 1
Make 20% missible oil according to following formula in the present embodiment, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:1:
Conventionally in the preparation method of middle missible oil and the present embodiment, formula prepares miticide.
Embodiment 2
Make 15% missible oil according to following formula in the present embodiment, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:2.
Conventionally in the preparation method of middle missible oil and the present embodiment, formula prepares miticide.
Embodiment 3
Become the aqueous emulsion of 5% in the present embodiment according to following recipe configuration, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:1.
Conventionally in the preparation method of middle aqueous emulsion and the present embodiment, formula prepares miticide.
Embodiment 4
Become the aqueous emulsion of 6% in the present embodiment according to following recipe configuration, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:2.
Conventionally in the preparation method of middle aqueous emulsion and the present embodiment, formula prepares miticide.
Embodiment 5
Become the microemulsion of 5% in the present embodiment according to following recipe configuration, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:1.
Conventionally in the preparation method of middle microemulsion and the present embodiment, formula prepares miticide.
Embodiment 6
Become 30% suspension according to following recipe configuration in the present embodiment, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:1.
Conventionally in the preparation method of middle suspension and the present embodiment, formula prepares miticide.
Embodiment 7
Become 50% water dispersible granules according to following recipe configuration in the present embodiment, wherein the mass ratio of active ingredient ivermectin and second mite azoles is 1:1.
Conventionally in the preparation method of middle water dispersible granules and the present embodiment, formula prepares miticide.
By ivermectin and the second mite azoles composite control citrus Jie-Li enzyme-SQ test of pesticide effectiveness as follows: test field tested by the oranges and tangerines of Xie Ma town, For It In Beibei, Chongqing and carry out.Orchard physical features is smooth, and illumination condition is good, and growing way is even, and rich water quality management level is consistent.Trial crops is 7-8 raw trifoliate orange anvil brocade orange, seeding row spacing 2.5m × 4m, every 667m
2plant 66 strains, average plant height 1.55m, hat width 1.47m, duration of test does not apply fertilizer, and irrigates yet.Test is divided into the clear water zone adopting clear water process, and with district in contrast, adopt the treatment region of chemicals treatment, treatment region has 5, and the number of processes of each treatment region is 4 times.Every community 2-3 strain tree, nurse tree is stayed in minizone.During test, citrus red mite (crm) ovum, larva and female adult pest all exist.With " MATABI " super green 16 type knapsack sprayer sprayings, operating pressure about 3 atmospheric pressure, spray orifice bore open 1.0mm, injection flow rate 0.5L per minute, spray drop diameter 80-100 μm.Every strain tree spray liquid amount 1.5kg.2 strain trees are investigated in every community, in tree crown all directions, 5 orientation respectively mark the raw then spring tip branch that has mite, respectively at the movable mite number investigated for 1,3,10,15,20,30 day before medicine and after medicine on the killed leaf of each mark branch 2-3 sheet, 25 leaves are looked in every community, often process 100 leaves.
Drug effect computational methods: control efficiency (100%)=[1-(before the medicine of check plot after mite number × treatment region medicine mite number)/(after the medicine of check plot before mite number × treatment region medicine mite number)]
Result of the test is as shown in the table:
Note: different capitalization represents that through Deng Kenshi duncan's new multiple range method test difference extremely significantly (p<0.01) different lowercase alphabet shows significant difference (p<0.05).
As can be seen from field test results, 6% composite aqueous emulsion with 5% microemulsion compared with contrast medicament, quick-acting has better performance, is better than contrast medicament 110g/L second mite azoles, 0.5% abamectin emulsifiable concentrate and 240g/L spiral shell mite ester.Lasting effect and 110g/L second mite azoles and 240g/L spiral shell mite ester indifference significance, but be better than 0.5% ivermectin missible oil.
Safety: do not find to produce poisoning to citrus, safer to natural enemy.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (9)
1. a miticide composition, is characterized in that: the material composition of described miticide composition is ivermectin and second mite azoles.
2. miticide composition as claimed in claim 1, is characterized in that: the mass ratio of described ivermectin and second mite azoles is 1:10 ~ 10:1.
3. a miticide, is characterized in that: described miticide comprise as arbitrary in claim 1 ~ 2 as described in miticide composition.
4. miticide as claimed in claim 3, it is characterized in that: in described acaricidal gross mass for benchmark, the mass fraction of described miticide composition is 1 ~ 50wt%.
5. miticide as claimed in claim 3, is characterized in that: described miticide is the one in missible oil, aqueous emulsion, suspending agent, microemulsion or water dispersible granules.
6. miticide as claimed in claim 3, is characterized in that, described miticide comprise be selected from solvent, surfactant, carrier, antifreezing agent, stabilizing agent, thickener, preservative and disintegrant one or more.
7. miticide as claimed in claim 6, it is characterized in that: described solvent is selected from solvent naphtha S-150#, dimethylbenzene, dimethyl sulfoxide (DMSO), cyclohexanone, N, one or more in N dimethyl pyrrolidone, DMF, methyl alcohol, ethanol, biodiesel, monoethanolamine, isopropylamine, methyl oleate, ethyl acetate, ethylene glycol monomethyl ether, butyl ether and water.
8. miticide as claimed in claim 6, is characterized in that: described surfactant is non-ionic surface active agent or anion surfactant.
9. one kind as arbitrary in claim 3 ~ 8 as described in miticide control vegetables and fruit mite pest on purposes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510349982.XA CN104996438A (en) | 2015-06-24 | 2015-06-24 | Miticidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510349982.XA CN104996438A (en) | 2015-06-24 | 2015-06-24 | Miticidal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104996438A true CN104996438A (en) | 2015-10-28 |
Family
ID=54369566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510349982.XA Pending CN104996438A (en) | 2015-06-24 | 2015-06-24 | Miticidal composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104996438A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107318861A (en) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination |
| CN107648247A (en) * | 2017-09-08 | 2018-02-02 | 东北林业大学 | A kind of subcutaneous implantation sustained release preparation of efficiently preventing and treating animal acarid disease |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406197A (en) * | 2008-11-19 | 2009-04-15 | 陕西韦尔奇作物保护有限公司 | Compositional mite-killing composition containing spirodiclofen and ivermectin |
| CN104255751A (en) * | 2014-09-15 | 2015-01-07 | 广东中迅农科股份有限公司 | Mite-killing composition containing etoxazole and vermectin |
| CN104522000A (en) * | 2014-12-23 | 2015-04-22 | 广东中迅农科股份有限公司 | Acaricidal composition containing cyflumetofen and ivermectin |
| CN104542647A (en) * | 2015-01-27 | 2015-04-29 | 西南大学 | Mite killing composition containing ivermectin and cyflumetofen |
-
2015
- 2015-06-24 CN CN201510349982.XA patent/CN104996438A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406197A (en) * | 2008-11-19 | 2009-04-15 | 陕西韦尔奇作物保护有限公司 | Compositional mite-killing composition containing spirodiclofen and ivermectin |
| CN104255751A (en) * | 2014-09-15 | 2015-01-07 | 广东中迅农科股份有限公司 | Mite-killing composition containing etoxazole and vermectin |
| CN104522000A (en) * | 2014-12-23 | 2015-04-22 | 广东中迅农科股份有限公司 | Acaricidal composition containing cyflumetofen and ivermectin |
| CN104542647A (en) * | 2015-01-27 | 2015-04-29 | 西南大学 | Mite killing composition containing ivermectin and cyflumetofen |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107318861A (en) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination |
| CN107648247A (en) * | 2017-09-08 | 2018-02-02 | 东北林业大学 | A kind of subcutaneous implantation sustained release preparation of efficiently preventing and treating animal acarid disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104322558A (en) | Sterilization composition and applications thereof | |
| CN102960361A (en) | Insecticide composition and application thereof | |
| CN102986700A (en) | Insecticide composition containing flutenzine and bistrifluron | |
| CN105284917B (en) | A kind of plant pesticide composition containing nimbin and caryophyllus oil | |
| CN108935477A (en) | A kind of suspension seed-coating agent and its application | |
| CN104996438A (en) | Miticidal composition | |
| CN103271051A (en) | Tolfenpyrad-diafenthiuron composite insecticide composition having synergism | |
| CN104542647B (en) | A kind of miticide composition comprising ivermectin and cyflumetofen | |
| CN105010315A (en) | Dispersable oil suspending agent containing acetamiprid and carbosulfan and application | |
| CN105123700A (en) | Insecticidal and bactericidal agent with thymol and arecoline and preparation method of insecticidal and bactericidal agent | |
| CN106561657B (en) | A kind of Pesticidal combination containing Celastrus angulatus and ethyl pleocidin | |
| CN109042715A (en) | One kind is containing double third ring worm esters and four chlorantraniliprole compositions | |
| CN103875714A (en) | Bacillus thuringiensis.spinosyns.trisiloxane polyoxyethylene ether composition and use of bacillus thuringiensis.spinosyns.trisiloxane polyoxyethylene ether composition for preventing and controlling rice boring insects | |
| CN103918705B (en) | Pesticidal combination containing spiral shell worm ethyl ester and gamma cyhalothrin and application thereof | |
| CN106508944A (en) | Pesticidal composition containing 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole and prochloraz | |
| CN105685110A (en) | Plant source composite for preventing cutworms and plant source insecticide and application thereof | |
| CN104115833A (en) | Insect and mite killing composition containing pyriproxyfen and cyflumetofen | |
| CN104522036B (en) | Insecticidal composition used for preventing and controlling lepidoptera pests and homoptera pests | |
| CN105532736B (en) | A kind of composition pesticide and its application | |
| CN104522006B (en) | A kind of preventing and treating Lepidoptera and homoptera pest compositions | |
| CN103271042B (en) | Etoxazole-hexythiazomiticide miticide composition | |
| CN106212489A (en) | Pyrifluquinazon and bistrifluron complex composition | |
| CN102273481B (en) | Dinotefuran-containing pesticidal composition | |
| CN106900756B (en) | Insecticidal composition of pueraria peduncularis extract and azadirachtin for preventing and treating agricultural pests and application thereof | |
| CN104304285B (en) | Compound insecticidal water emulsion agent for preventing and treating contariniapyrivora |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151028 |