CN104542647B - A kind of miticide composition comprising ivermectin and cyflumetofen - Google Patents
A kind of miticide composition comprising ivermectin and cyflumetofen Download PDFInfo
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- CN104542647B CN104542647B CN201510040749.3A CN201510040749A CN104542647B CN 104542647 B CN104542647 B CN 104542647B CN 201510040749 A CN201510040749 A CN 201510040749A CN 104542647 B CN104542647 B CN 104542647B
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- ivermectin
- cyflumetofen
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Abstract
The present invention relates to a kind of Synergistic mite killing composition containing ivermectin and cyflumetofen, the mass fraction of ivermectin and cyflumetofen is than being 1:4 ~ 4:1.Synergistic mite killing composition of the present invention is applicable to agriculturally prevent and treat various harmful mite; Improve mite, ovum control efficiency; Reduce Pesticide use amount, thus reduce cost and decrease the pollution to environment, to person poultry safety.The present invention is made up of the active ingredient of different mechanism of action, and action site increases, and be conducive to overcoming and delay the drug-fast generation of insect pest mite, and widened insecticidal spectrum, it applies larger economic benefit and social benefit.
Description
Technical field
The invention belongs to pesticides application technical field, relate to a kind of composition pesticide, specifically be a kind of miticide composition containing ivermectin and cyflumetofen.
Background technology
Ivermectin, English name Ivermectin (being called for short IVM) is first the Avermectins medicine derivative by Merck company of the U.S., the double-bond hydrogenation between C22 and the C23 of Avermectin active component B1 being reduced into saturation state and developing.As the structure optimization product of agricultural antibiotic, with current compared with the homologue Avermectin of agriculturally extensive use, ivermectin not only remains its expelling parasite and acaricidal activity, and safety is higher, and stability is better, not easily produces resistance.Southwestern University Li Jing etc. compares research to the biologically active of ivermectin and Avermectin, and result of study shows, ivermectin has and good kills mite and eelworm-killing activity.Current ivermectin mainly as veterinary drug use and agriculturally use less.If can by ivermectin and suitable pesticide compositional, increase virulence, delaying drug resistance, then the new prospect of will open up ivermectin and apply at agriculture field.
Cyflumetofen; English name Cyflumetofen; that nitrile is novel kills mite and nematocide for the benzoyl reported the earliest in 2004 by Japanese great Zhong chemical company; within 2007, get permission to register in Japan first and sell, being mainly used in preventing and treating all kinds of harmful mite parasitized on fruit tree, vegetables, tea and ornamental plants.To the ovum of tetranychid with to become mite all effective, if higher to the activity of mite, with existing insecticide without cross resistance.Cyflumetofen action target is mitochondrial complex II, suppress to be that the mite chondrioid of substrate is breathed with succinic acid, to the difference of mite chondrioid inhibit activities, make it high and to vertebrate low toxicity to mite class selectivity, to plant without poisoning, it is environmentally friendly agricultural chemicals.
Tetranychus cinnabarinus is a kind of important Agricultural Mites, is one of the most serious arthropods of resistance problems, the various crop such as serious harm cotton, corn.China widely distributed and be difficult to again control.Above long-term to continue owing to producing, not science large area use chemical pesticide control, Tetranychus cinnabarinus has been caused to produce more and more serious resistance to Multiple Pesticides, control efficiency is caused to reduce year by year, development of drug resistance is rapid, the supply of effective agent is made to seem all the more short, investment and the risk of adding new varieties of pesticides research and production are increasing, the cycle of the market development is more and more longer, therefore be badly in need of the Pesticidal products of more efficient, safety, environmental protection, the composite or mixture of insecticidal/acaricidal agent is one of the effective method the most solved the problem.
Expanding prevention can be composed, reduce dosage and production cost by composite, and slow down the pesticide resistance of pest to medicament to a certain extent, the aspects such as environmentally safe property have great importance.
Current State Intellectual Property Office inquires authorizedly has ivermectin and pyridaphethione Recompounded pesticide about the composite patent of ivermectin, 20% ivermectin chlorpyrifos aqueous emulsion, based on the composition pesticide etc. of ivermectin, composite patent about cyflumetofen has a kind of containing cyflumetofen insecticide acaricide composition, a kind of miticide composition containing phonetic mite amine and cyflumetofen, comprise the Insecticidal combinations of Avermectin and cyflumetofen, a kind of Synergistic mite killing composition etc. containing cyflumetofen and clofentezine, exploitation ivermectin is described, cyflumetofen built agent of being correlated with has good application prospect.
The present invention is by a large amount of desk research, filter out the complex composition of ivermectin and cyflumetofen, ivermectin is different from the mechanism of action of cyflumetofen, mutually composite have good synergistic effect within the specific limits, decrease the dosage of agricultural chemicals, reduce the residual quantity of agricultural chemicals on crop, decrease environmental pollution; Person poultry safety, good, the harmful mite of Environmental compatibility are not easily developed immunity to drugs.Composite and the application of current ivermectin and cyflumetofen there is no people both at home and abroad and reported.
Summary of the invention
Based on above situation, the object of the present invention is to provide a kind of agricultural chemicals miticide composition, this miticide composition is characterized in that with ivermectin and cyflumetofen for active ingredient carries out mixture, the multiple harmful mite of control crops, can synergy, strengthen ovum further, mite is double controls effect, delaying drug resistance, extends the service time of novel miticide cyflumetofen.
For achieving the above object, the technical solution used in the present invention is: a kind of miticide composition comprising ivermectin and cyflumetofen, described composition active ingredient is ivermectin and cyflumetofen, and the mass ratio both it is 1:4 ~ 4:1, and described composition also comprises auxiliary agent, solvent and filler.
Further: described ivermectin and cyflumetofen mass ratio are 1:1 ~ 1:2.
Further: described active ingredient accounts for 1% ~ 50% of composition weight percentage.
Further: described in be selected from solvent naphtha S-150#, dimethylbenzene, dimethyl sulfoxide (DMSO), cyclohexanone, 1-METHYLPYRROLIDONE, DMF, methyl alcohol, ethanol, biodiesel, monoethanolamine, isopropylamine, methyl oleate, ethyl acetate, ethylene glycol monomethyl ether, butyl ether, water any one or more with arbitrary proportion composition mixed solvents.
Further: described combination dosage form is missible oil, aqueous emulsion, suspending agent, microemulsion, water dispersible granules.
Advantageous Effects of the present invention is: miticide composition of the present invention has obviously synergistic effect.Being particularly suitable for the mite pest for preventing and treating vegetables and fruit, being especially suitable for control Tetranychus cinnabarinus, Tetranychus urticae, apple, panonychus citri, cotton spider mites etc.
Embodiment
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
One, test method
For examination worm source: Tetranychus cinnabarinus sensitive strain; strain obtained for many years has been raised with potted plant cowpea seedling; raise in plant protection institute of Southwestern University insectary, in illumination box (temperature 26 soil 1 DEG C, relative moisture 60%-80%, illumination L:D=14:10h).
Trial drug: the former medicine of ivermectin (96.06%), the former medicine of cyflumetofen (97%).
The Toxicity Determination method of single dose: adopt medicine embrane method, take former medicine, be configured to series concentration gradient with acetone, by the solution configured, gets 1.5-2.0ml respectively and injects the centrifuge tube (mark drug concentration, mite) marked.Blank adopts acetone.Centrifuge tube is put upside down jolting more than 30 times, make medicament be evenly distributed on tube wall.Pour out liquid, centrifuge tube is placed in suction in ventilating kitchen and spends the night.Picking leaf butterfly is upper to be raised, and individuality is comparatively large, and the female one-tenth mite of dynamic and homogeneous 3-5 age in days is in the centrifuge tube handled well, centrifuge tube is collected in porcelain dish, be placed on 24h in constant incubator, take out the centrifuge tube of 24h in constant incubator, the mite of the inside is poured on a clean blank sheet of paper.Observe mite, statistics death toll and survival number.Observation process is carried out under anatomical lens, touches polypide with writing brush, with completely motionless or only have a foot to be death dynamic.Carry out data processing with PoloPlus software, try to achieve virulence regression equation and lethal concentration of 50 LC
50.
The joint toxicity measuring method of different ratio
According to the toxicity test result of single dose, 5 proportionings are selected when evaluating the synergistic effect of ivermectin and cyflumetofen mixture by common malicious factorization method, these 5 proportionings are six Along ents of summation action line in isoboles, can be expressed as a/5b, a/2b, a/b, 2a/b, 5a/b.The concentration of these 5 proportioning mixtures is respectively (a+5b)/6, (a+2b)/3, (a+b)/2, (2a+b)/3, (5a+b)/6.Concrete compound method will be for becoming lethal concentration of 50 liquid for examination single dose mother liquor acetone diluted, then 1:5,1:2,1:1,2:1,5:1 mix and obtain different ratio mixture liquid by volume.When the common malicious factor >=20 indicate synergistic effect ,≤-20 indicate antagonism, and-20< altogether malicious factor <20 is expressed as summation action.Computing formula is as follows:
The malicious factor=100 altogether × (mixture observes the theoretical lethality of lethality-mixture) theoretical lethality of/mixture
According to common malicious factorization method measurement result, ivermectin and cyflumetofen is composite synergistic effect, can carry out composite, set ivermectin further: cyflumetofen mass ratio is 1:4,1:2,3:7,2:3,1:1,3:2,4:1, verifies its synergistic effect by co-toxicity coefficient method.Adopt medicine embrane method to carry out Toxicity Determination, calculate LC
50, and press abundant method calculating co-toxicity coefficient (CTC) of Sun Yun.Co-toxicity coefficient CTC, if confection is M, each single dose of composition M is A, B.Toxicity index TI, active ingredient percentage composition is P, and co-toxicity coefficient method computing formula is as follows:
Toxicity index (TI)=(acaricidal LC of standard
50/ for the acaricidal LC of examination
50) × 100
AT1=(the acaricidal LC of standard of M
50the LC of/M
50) × 100
TT1=T1A × PA+T1B × the PB of M
The CTC=(TTI of the AT1/M of M) × 100 of M
ATI---is actual records mixed toxicity index
The toxicity index that TTI---theory is mixed
The co-toxicity coefficient of CTC---built agent
Together, whether synergy is determined by CTC (co-toxicity coefficient) value two kinds of medicament mixtures, and CTC≤80 are antagonism, and 80<CTC<120 is summation action, and CTC≤120 are synergistic effect.
Result of the test
Table one, altogether malicious factor toxicity test result:
Table two, co-toxicity coefficient toxicity test result:
Can be obtained by the data of table one, ivermectin and the effect of cyflumetofen compound synergic obvious.Composite feasibility is high, can be found out by table two data: ivermectin: during cyflumetofen=1:2,3:7,1:1, co-toxicity coefficient is higher than 170, there is notable synergistic effect, especially during 1:2 and 1:1, co-toxicity coefficient value up to 245.01 and 265.66, prove ivermectin provided by the invention and cyflumetofen composite to evil mite have good preventive effect.
The formulations of pesticide prepare embodiment
Embodiment 1 (20% missible oil, active ingredient is than 1:1)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 10%, cyflumetofen (active ingredient) 10%, N, N dimethyl pyrrolidone 5%, agriculture breast 602#5%, agriculture breast BY-125#6%, BHT1% solvent naphtha S-150# supply 100%.
Embodiment 2 (15% missible oil, active ingredient is than 1:2)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 5%, cyflumetofen (active ingredient) 10%, agriculture breast 601#5%, agriculture breast 0203B5%, BHT1%, cyclohexanone 5%, solvent naphtha S-150# supply 100%,
Embodiment 3 (5% aqueous emulsion, active ingredient 1:1)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 2.5%, cyflumetofen (active ingredient) 2.5%, N, N dimethyl pyrrolidone 5%, solvent naphtha S-150#12%, BHT1%, Termul2005%, agriculture breast 601#5%, ethylene glycol 3%, water supply 100%.
Embodiment 4 (6% aqueous emulsion, active ingredient 1:2)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 2%, cyflumetofen (active ingredient) 4%, solvent naphtha S-150#12%, cyclohexanone 5%, BY-120#4.5%, agriculture breast 601#6.5%, BHT1%, ethylene glycol 4%, water supply 100%.
Embodiment 5 (5% microemulsion, active ingredient 1:1)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 15%, cyflumetofen (active ingredient) 15%, solvent naphtha S-150#12%, N, N dimethyl pyrrolidone 4%, EmulsogenEL3605%, agriculture breast 0203B4.5%, water complement to 100%.
Embodiment 6 (30% suspending agent, active ingredient 1:1)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 15%, cyflumetofen (active ingredient) 15%, castor oil polyoxyethylene ether (dispersant) 3%, polyoxyethylene nonylphenol ether (wetting agent) 1%, ethylene glycol (antifreezing agent) 3%, BHT (stabilizing agent) 1%, aluminium-magnesium silicate (thickener) 1%, xanthans (thickener) 0.3%, Sodium Benzoate (preservative) 0.2%, water complement to 100%.
Embodiment 7 (50% water dispersible granules, active ingredient 1:1)
The following raw materials according of percentage by weight: ivermectin (active ingredient) 25%, cyflumetofen (active ingredient) 25%, lauryl sodium sulfate (dispersant) 4%, calcium dodecyl benzene sulfonate (wetting agent) 6%, organosilicon breast (defoamer) 0.15%, diatomite supply surplus 100%.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. comprise a miticide composition for ivermectin and cyflumetofen, it is characterized in that: described composition active ingredient is ivermectin and cyflumetofen, the mass ratio both it is 1:4 ~ 4:1, and described composition also comprises auxiliary agent, solvent and filler.
2. comprise the miticide composition of ivermectin and cyflumetofen according to claim 1, it is characterized in that: described ivermectin and cyflumetofen mass ratio are 1:1 ~ 1:2.
3. comprise the miticide composition of ivermectin and cyflumetofen according to claim 2, it is characterized in that: described active ingredient accounts for 1% ~ 50% of composition weight percentage.
4. comprise the miticide composition of ivermectin and cyflumetofen according to claim 3, it is characterized in that: described in be selected from solvent naphtha S-150#, dimethylbenzene, dimethyl sulfoxide (DMSO), cyclohexanone, 1-METHYLPYRROLIDONE, DMF, methyl alcohol, ethanol, biodiesel, monoethanolamine, isopropylamine, methyl oleate, ethyl acetate, ethylene glycol monomethyl ether, butyl ether, water any one or more with arbitrary proportion composition mixed solvents.
5. according to any one of Claims 1 to 4, comprise the miticide composition of ivermectin and cyflumetofen, it is characterized in that: described combination dosage form is missible oil, aqueous emulsion, suspending agent, microemulsion, water dispersible granules.
6. according to any one of Claims 1 to 4, comprise the purposes of the miticide composition of ivermectin and cyflumetofen, it is characterized in that: described composition is as agricultural acaricides, good to Tetranychus cinnabarinus control efficiency spy.
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| CN104542647B true CN104542647B (en) | 2016-04-06 |
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| CN104996438A (en) * | 2015-06-24 | 2015-10-28 | 西南大学柑桔研究所 | Miticidal composition |
| CN109699649B (en) * | 2019-01-28 | 2020-10-27 | 南开大学 | Acaricidal composition containing cyflumetofen |
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| DE102007045922A1 (en) * | 2007-09-26 | 2009-04-02 | Bayer Cropscience Ag | Drug combinations with insecticidal and acaricidal properties |
| AR086588A1 (en) * | 2011-05-31 | 2014-01-08 | Syngenta Participations Ag | PESTICIDE MIXTURES THAT INCLUDE ISOXAZOLINIC DERIVATIVES |
| CN104522000B (en) * | 2014-12-23 | 2018-02-06 | 广东中迅农科股份有限公司 | A kind of miticide composition containing cyflumetofen and ivermectin |
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