CN104585179B - A kind of Synergistic mite killing composition containing tebufenpyrad and spirodiclofen - Google Patents
A kind of Synergistic mite killing composition containing tebufenpyrad and spirodiclofen Download PDFInfo
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- CN104585179B CN104585179B CN201410822625.6A CN201410822625A CN104585179B CN 104585179 B CN104585179 B CN 104585179B CN 201410822625 A CN201410822625 A CN 201410822625A CN 104585179 B CN104585179 B CN 104585179B
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Abstract
The present invention relates to a kind of Synergistic mite killing composition containing tebufenpyrad and spirodiclofen, the ratio of weight and number of tebufenpyrad and spirodiclofen is 20:1~1:20, the percentage by weight of tebufenpyrad and spirodiclofen weight summation in miticide composition is 5% 80%.Two kinds of active ingredient compoundings of the present invention have obvious synergistic effect, have excellent prevention effect to various mite pests on the crops such as fruit tree, vegetables, cotton and flowers；The present invention improves prevention effect；Pesticide use amount is reduced, so as to reduce cost and reduce the pollution to environment, is advantageous to the resistance management of evil mite, its popularization and application has larger economic benefit and social benefit.
Description
Technical field
The present invention relates to agricultural chemicals miticide composition and its application field, and specifically one kind is with tebufenpyrad and spirodiclofen
For the Synergistic mite killing composition of active ingredient, the preventing and treating applied to evil mite on fruit tree, cotton and vegetables.
Background technology
Tebufenpyrad is a kind of obligate acaricide, belongs to Mitochondria In Developing Flight Muscle of Insects respiration inhibitor, and its mechanism of action is pressed down at the I of site
Electron transmission processed, rather than the biogenic amine or acetylcholinergic receptor acted in insect bodies, nor as special muscle or
Never poison, its physiology drug effect is rapid, and to red spider ovum, preferable into mite effect, the lasting period up to more than 40 days, has certain
Resistance of rainwater washing against ability.
The mechanism of action of spirodiclofen is mainly the synthesis for suppressing mite class fat, and spirodiclofen is on the basis of Envidor
The novel pesticide formed is transformed, its activity is 2-3 times of Envidor, to red spider, blister mite, yellow tea mite, Tetranychus cinnabarinus and two spots
Tetranychid etc. has good preventive effect.
Mite class is a kind of common crop such as insect, danger to vegetables, fruit tree and cotton, and destructive calamity is often caused to crop
Evil.Evil mite generation is more from generation to generation, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity is rapid in the short period of time
Exponentially increase, thus easily acaricide is developed immunity to drugs, while cause to seriously endanger to crop.
Different pesticide species compositions are compounded, and are the common methods for preventing and treating agriculture resistant insect evil mite.The present inventor exists
On the basis of substantial amounts of indoor virulence and field medicine effect test, depth has been carried out to tebufenpyrad and the screening of the compounded formula of spirodiclofen
Enter research, it is found that tebufenpyrad and spirodiclofen are compounded, there is obvious synergistic function in certain proportion,
And there is outstanding prevention effect to various evil mites, after further study, complete the present invention.
The content of the invention
It is an object of the invention to provide a kind of compound synergic composition containing tebufenpyrad and spirodiclofen, applied to fruit
The preventing and treating of evil mite on tree, cotton and vegetables.
Another object of the present invention is to the miticide composition containing tebufenpyrad and spirodiclofen, can reduce in use
Dosage, reduce residual quantity of the agricultural chemicals on crops, delay the drug-fast generation of mite pest, moreover it is possible to making it to various mite class
The prevention effect of insect is used alone to compare than single dose and significantly improved, laborsaving, economical, reduces farmer's burdens.
Technical scheme：A kind of Synergistic mite killing composition, active ingredient are made up of tebufenpyrad and spirodiclofen, pyrrole
Mite amine and the ratio of weight and number of spirodiclofen are 20:1~1:20, tebufenpyrad and spirodiclofen weight summation are in miticide composition
Percentage by weight be 5%-80%, remaining be agricultural chemicals in allow use and acceptable auxiliary element.
The composition pesticide of the present invention can use known method to be prepared into any one agent for being adapted to agriculturally use
Type, relatively good formulation are suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wettable powder.
The auxiliary agent used in the present composition includes solvent, dispersant, stabilizer, emulsifying agent, antifreezing agent, thickener etc.
And other are beneficial to the known substance that drug effect is stablized and played to active ingredient in the formulation, commonly used or allow in pesticidal preparations
The various composition used, is not particularly limited, and specific composition and dosage are according to recipe requirements by simply testing determination.
Product described in the invention can be provided in the form of finished product preparation, i.e., each material is blended in composition, group
The composition of compound can also single dose form provide, directly mixed using preceding in tank or bucket, be then diluted to required for it is dense
Degree.
Miticide composition of the present invention is applied to various mite pests on the crops such as preventing and treating fruit tree, vegetables, cotton.
The frequency of administration of miticide composition of the present invention and amount of application change and changed with weather condition and crop condition, can be with
Reach the purpose of preventing and treating by using appropriate formulation.
Compared with prior art, the advantage of the invention is that：
1st, tebufenpyrad and spirodiclofen compounding have obvious synergistic function, are used alone and are improved to evil than single dose
The prevention effect of mite；
2nd, tebufenpyrad and the spirodiclofen mechanism of action are different, can delay the drug-fast generation of evil mite；
3rd, two kinds of active ingredients of tebufenpyrad and spirodiclofen compounding, reduces Pesticide use amount, reduce use cost and
Alleviate the pollution to environment.
Embodiment
Essence for a better understanding of the present invention, present disclosure is described further with reference to embodiment,
But limitation of the present invention can not be considered as, it is as described below to be only used for explaining the present invention, for without departing from spirit of the invention and principle
Modification, replacement or the improvement made, belong to the scope of protection of present invention.
Active ingredient is using 93% tebufenpyrad active compound, 97% spirodiclofen active compound in the embodiment of the present invention, institute in embodiment
The each component percentage composition stated is weight percentage.
Example of formulations 1：25% tebufenpyrad spirodiclofen suspending agent.
Tebufenpyrad 20%, spirodiclofen 5%, alkyl naphthalene formaldehyde condensation product sodium sulfonate 10%, Nekal BX 10%, methylol
Cellulose 1%, glycerine 2%, silicone oil 0.1%, deionized water supplies 100%.By above-mentioned active ingredient, dispersant, wetting agent,
Thickener, antifreezing agent, defoamer and deionized water mixing, disperse through high speed shear, are sanded in sand mill, the shape in water-medium
Into high dispersive, stable suspension system, you can 25% tebufenpyrad spirodiclofen suspending agent is made.
Example of formulations 2：30% tebufenpyrad spirodiclofen aqueous emulsion.
Tebufenpyrad 25%, spirodiclofen 5%, coconut oil heptyl ester 20%, NPE 15%, alkylnaphthalene sulphur
Hydrochlorate 5%, sodium sorbate 1%, glycerine 1%, deionized water supplies 100%.By above-mentioned active ingredient, solvent, emulsifying agent, point
Powder and stabilizer are mixed to form oil phase, and antifreezing agent dissolves in water forms aqueous phase, and slowly oil phase is added under cutter effect
Enter in aqueous phase, and continue shearing about 30 minutes, you can 30% tebufenpyrad spirodiclofen aqueous emulsion is made.
Example of formulations 3：42% tebufenpyrad spirodiclofen microemulsion.
Tebufenpyrad 35%, spirodiclofen 7%, cyclohexanone 10%, DMF 10%, styrylphenol gather
Oxygen vinethene 15%, xylitol 1.5%, organosilicon 1.5%, thiophene ketone 2%, deionized water supplies 100%.By active ingredient with molten
Agent is completely dissolved, and is then added emulsifying agent, stabilizer, bleeding agent, synergist and is well mixed, is eventually adding deionized water, fills
After dividing stirring, you can 42% tebufenpyrad spirodiclofen microemulsion is made.
Example of formulations 4：40% tebufenpyrad spirodiclofen wettable powder.
Tebufenpyrad 30%, spirodiclofen 10%, alkyl naphthalene formaldehyde condensation product sodium sulfonate 5%, calcium dodecyl benzene sulfonate
10%, diatomite supplies 100%.Active ingredient, dispersant, wetting agent and filler are mixed by above-mentioned, passed through again after mechanical crushing
Air-flow crushing, it is well mixed, you can 40% tebufenpyrad spirodiclofen wettable powder is made.
Example of formulations 5：35% tebufenpyrad spirodiclofen water dispersible granules.
Tebufenpyrad 28%, spirodiclofen 7%, APES 10%, neopelex 10%, carbonic acid
Sodium 3%, polyvinyl alcohol 2%, kaolin supplies 100%.By above-mentioned active ingredient, dispersant, wetting agent, disintegrant, binding agent
It is well mixed with filler, is crushed with micro jet, through mediating, then adds in fluidized-bed granulation dryer and made
Grain, dry, screening, you can 35% tebufenpyrad spirodiclofen water dispersible granules are made.
Assays Example 1：The indoor joint toxicity measuring of tebufenpyrad and spirodiclofen to panonychus citri
Test medicine uses 93% tebufenpyrad active compound and 97% spirodiclofen active compound.
Test worm is to gather the panonychus citri deutonymph through the generation of indoor feeding 3 from citrus orchard.
Test method is using (the reference of leaf butterfly spray-on process《NY/T 1154.13-2008 farm-chemical indoor determination test rules
The parts of insecticide the 13rd：Leaf butterfly spray-on process》).Concrete operation method is as follows：
Each single dose and Mixed Pharmacy are set into 5 different concentration gradients, and (on the basis of pilot study result, citrus is complete
The pawl mite deutonymph death rate is set in the range of 5%-90% by geometric progression).
Choose and grow consistent Citrus leaf, make leaf butterfly with card punch, a wet sponge block is placed in culture dish, thereon
Put filter paper, foliation butterfly on filter paper, 2 pieces of leaf butterflies are put per ware, panonychus citri deutonymph inoculation that select health, that Individual Size is consistent
Onto leaf butterfly, 20 are inoculated with per leaf butterfly.
The culture dish for being connected to leaf butterfly is placed under potter spray towers, sprayed under 50PSI pressure, spray amount 1ml, is sunk
Culture dish is taken out after drop 1min, then treated culture dish is put into 12H/12H illumination boxs and cultivated, 48h checks dead
Mite number, calculate the death rate.Often processing sets 4 repetitions, and sets clear water blank control processing.
Statistical analysis is carried out with DPS statistical analysis softwares, by the LC for calculating each medicament50Lived to evaluate the mite killing of each medicament
Property, and according to the co-toxicity coefficient (CTC values) of the abundant method calculating mixtures of Sun Yun.
Survey toxicity index (ATI)=(standard agent LC50/ reagent agent LC50)×100。
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
B percentage composition in agent.
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100.
The criteria for classifying is acted on according to NY/T11547.7-2006 insecticide combinations：Co-toxicity coefficient (CTC) >=120 is shown as
Synergistic effect；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients (CTC) ＜ 120, which show as being added, to be made
With.
As it can be seen from table 1 tebufenpyrad and spirodiclofen are 20:1~1:It is malicious altogether when being compounded in the range of 20 (by weight)
Coefficient (CTC) is all higher than 120, and obvious synergistic function is shown to panonychus citri deutonymph.It can be seen that tebufenpyrad and spiral shell mite
Dibasic acid esters compounding has reasonability and feasibility.
The indoor joint toxicity measuring result of table 1, tebufenpyrad and spirodiclofen to panonychus citri deutonymph
Assays Example 2：Tebufenpyrad and spirodiclofen compound the field control effectiveness test to panonychus citri.
It is used to prevent and treat panonychus citri using 25% tebufenpyrad spirodiclofen suspending agent (example of formulations 1), before dispenser
Insect population is investigated, 3d, 7d, 14d, 30d investigate residual mite number living respectively after medicine, look into 2 plants per cell during investigation, every plant is pressed thing
5 blades are looked into 4, north and south orientation respectively, look into 40 blades altogether per cell, are recorded mite number living, are calculated prevention effect.Prevention effect
Computational methods are as follows：
Prevention effect (%)=(1-CK1×Pt1/CK2×Pt2)×100。
Wherein：CK1Represent insect population number before the medicine of check plot；Pt1Represent insect population number after treatment region medicine；
CK2Represent insect population number after the medicine of check plot；Pt2Represent insect population number before treatment region medicine；
The result of the test of table 2,25% tebufenpyrad spirodiclofen suspending agent preventing and treating panonychus citri
From table 2 it can be seen that 25% tebufenpyrad spirodiclofen suspending agent uses 1000~2000 times, 3d, 7d after medicine,
The preventive effect of panonychus citri is intended to after 14d, 30d apparently higher than the tebufenpyrad suspending agent single dose of the same period 30% using 1500 times and
5% spirodiclofen aqueous emulsion single dose uses 1000 times, illustrates that phase is used alone with two kinds of single doses in tebufenpyrad and spirodiclofen compounding
Than that can improve to panonychus citri preventive effect, while 30d preventive effects still up to more than 80%, illustrate there is good lasting effect after medicine,
Do not find that the compound drug produces poisoning to citrus during experiment.
Assays Example 3：Tebufenpyrad and spirodiclofen compound the field control effectiveness test to cotton Tetranychus cinnabarinus.
It is used to investigate insect population base before preventing and treating dispenser using 30% tebufenpyrad spirodiclofen aqueous emulsion (example of formulations 2)
Number, 3d, 7d, 14d, 30d investigate residual mite number living respectively after medicine, look into 2 plants per cell during investigation, every plant is pressed the side of the four corners of the world 4
5 blades are looked into position respectively, and each cell looks into 40 blades altogether, record mite number living, calculate prevention effect.Prevention effect computational methods
It is as follows：
Prevention effect (%)=(1-CK1×Pt1/CK2×Pt2)×100。
Wherein：CK1Represent insect population number before the medicine of check plot；Pt1Represent insect population number after treatment region medicine；
CK2Represent insect population number after the medicine of check plot；Pt2Represent insect population number before treatment region medicine；
Table 3,30% tebufenpyrad spirodiclofen aqueous emulsion preventing and treating cotton Tetranychus cinnabarinus result of the test
30% tebufenpyrad spirodiclofen aqueous emulsion uses 1500~2500 times of 3d, 7d, 14d, 30d as can be seen from Table 3
Afterwards the preventive effect of cotton Tetranychus cinnabarinus is intended to use 1500 times and 5% spiral shell mite apparently higher than the tebufenpyrad suspending agent single dose of the same period 30%
Dibasic acid esters aqueous emulsion single dose uses 1000 times, illustrates that tebufenpyrad and spirodiclofen compounding can carry compared with two kinds of single doses are used alone
Height is to cotton Tetranychus cinnabarinus preventive effect, while 30d preventive effects still up to more than 80%, illustrate there is good lasting effect, experimental period after medicine
Between do not find the compound drug to cotton produce poisoning.
In summary, the present invention uses two kinds of active components as tebufenpyrad and the compound acaricide composition of spirodiclofen, with
Existing unitary agent is compared, not only with obvious synergistic effect, also with good miticidal effect, lasting period length, to agriculture
Crop safety, the drug-fast generation of evil mite can be slowed down, be worth the popularization and application in agricultural production.
Claims (3)
- A kind of 1. Synergistic mite killing composition containing tebufenpyrad and spirodiclofen, it is characterised in that：Active ingredient by tebufenpyrad and Spirodiclofen forms, and the ratio of weight and number of tebufenpyrad and spirodiclofen is 20:1~1:20, tebufenpyrad and spirodiclofen weight are total It is 5%-80% with the percentage by weight in miticide composition.
- A kind of 2. Synergistic mite killing composition containing tebufenpyrad and spirodiclofen according to claim 1, it is characterised in that： Formulation suspending agent, aqueous emulsion, microemulsion, water dispersible granules or the wettable powder for being adapted to agriculturally use are made during practical application Agent.
- 3. a kind of Synergistic mite killing composition containing tebufenpyrad and spirodiclofen according to claim 1 or 2 is used for agricultural Application in the upper various evil mites of preventing and treating.
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| US20130261163A1 (en) * | 2000-06-29 | 2013-10-03 | Bayer Cropscience Ag | Active compound combinations having insecticidal and acaricidal properties |
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| CN1635834A (en) * | 2000-03-21 | 2005-07-06 | 拜尔公司 | Combinations of active ingredients with insecticidal and acaricidal properties |
| US20130261163A1 (en) * | 2000-06-29 | 2013-10-03 | Bayer Cropscience Ag | Active compound combinations having insecticidal and acaricidal properties |
| CN101543213A (en) * | 2008-03-25 | 2009-09-30 | 山东京博控股发展有限公司 | Composition of insecticide and acaricide |
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