CN103271042B - Etoxazole-hexythiazomiticide miticide composition - Google Patents
Etoxazole-hexythiazomiticide miticide composition Download PDFInfo
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- CN103271042B CN103271042B CN201310122983.1A CN201310122983A CN103271042B CN 103271042 B CN103271042 B CN 103271042B CN 201310122983 A CN201310122983 A CN 201310122983A CN 103271042 B CN103271042 B CN 103271042B
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- etoxazole
- hexythiazox
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- hexythiazomiticide
- miticide composition
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Abstract
The invention discloses a kind of Etoxazole-hexythiazomiticide miticide composition, its active ingredient is etoxazole and Hexythiazox, and the weight ratio of etoxazole and Hexythiazox is 20:1~1:20.The miticide composition of the present invention has outstanding prevention effect to the evil mite on the crops such as fruit tree, cotton and vegetables, and with obvious synergistic function；Pesticide use amount is reduced simultaneously, the pollution to environment is alleviated, the drug-fast generation of evil mite is slow down.
Description
Technical field
It is effective specifically using etoxazole and Hexythiazox the present invention relates to agricultural chemicals miticide composition and its application field
The binary complex of composition compounding, the preventing and treating applied to evil mite on fruit tree, cotton and vegetables.
Background technology
Etoxazole, english common name：Etoxazole, is a kind of brand-new acaricide with special construction.It is acted on
Mode is to suppress the embry ogenesis of mite ovum and from young mite to the molting process into mite, effective to ovum and deutonymph, to invalid into mite.
Therefore, its optimal preventing and treating time is that evil mite endangers initial stage.The medicament rain fastness is strong, and the lasting period is up to 50 days, environmentally safe.
Have to the tetranychid on the crops such as citrus, cotton, apple, flowers, vegetables, beginning tetranychid, Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus etc.
There is remarkable preventive effect.
Hexythiazox, english common name：Hexythiazox, is a kind of new thiazolidine ketone acaricide.It is to a variety of
The evil mite of crop has strong ovicidal, kills the characteristic of children mite, to invalid into mite, but is produced to touching the female of decoction into mite
Ovum have suppress hatching effect.There are good permeability, no systemic action to plant tissue.
Mite class is the common insect of a class, the crop such as danger to vegetables, fruit tree and cotton, and destructive calamity is often caused to crop
Evil.Evil mite generation is more from generation to generation, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity is rapid in the short period of time
Exponentially increase, thus easily acaricide is developed immunity to drugs, while causing serious harm to crop.
Different pesticide species compositions are compounded, and are the common methods of the agriculture resistant insect evil mite of preventing and treating.The present inventor exists
On the basis of substantial amounts of indoor virulence and field medicine effect test, the compounded formula screening to etoxazole and Hexythiazox is goed deep into
Research, it is found that etoxazole and Hexythiazox are compounded, have obvious synergistic function in certain proportion, and right
Various evil mites have outstanding prevention effect, after further study, complete the present invention.
The content of the invention
It is an object of the invention to provide a kind of etoxazole and Hexythiazox compound synergic miticide composition, applied to fruit tree,
The preventing and treating of evil mite on cotton and vegetables.
Technical scheme：Using etoxazole and Hexythiazox as active ingredient, etoxazole and Hexythiazox are in the composition
Weight ratio be 20:1~1:20, the percentage by weight of etoxazole and Hexythiazox weight summation in composition pesticide be 5%~
80%, remaining be agricultural chemicals in allow use and acceptable auxiliary element.
Composition pesticide of the present invention can be prepared into any one formulation for being adapted to agriculturally use with known method, than
Preferable formulation has suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wettable powder and missible oil.
The auxiliary element used in the present composition includes solvent, emulsifying agent, wetting agent, stabilizer, dispersant, thickening
Agent, PH conditioning agents, defoamer, antifreezing agent, packing agent etc. are beneficial to active ingredient and stablize and play the known of drug effect in the formulation
Material, is all the various composition commonly used in pesticidal preparations or allow to use, and specific composition and consumption pass through examination according to recipe requirements
Test determination.
The frequency of administration and amount of application of the present composition change with crops, insect, weather condition and have small variations,
The purpose effectively prevented and treated can be reached by using appropriate dosage.
Compared with prior art, the advantage of the invention is that
1st, etoxazole and Hexythiazox compounding have obvious synergistic function, are used alone and are improved to evil than single dose
The prevention effect of mite
2nd, etoxazole and the Hexythiazox mechanism of action are different, can delay the drug-fast generation of evil mite
3rd, two kinds of active ingredient compoundings of etoxazole and Hexythiazox, reduce Pesticide use amount, reduce use cost and subtract
The light pollution to environment.
Embodiment
Essence for a better understanding of the present invention, is described further with reference to embodiment to present disclosure,
But limitation of the present invention can not be considered as.
（One）Formula and FORMULATION PROCESS EXAMPLES.
Effective constituents A uses 97% Hexythiazox active compound using 93% etoxazole active compound, active ingredient B in the embodiment of the present invention.
Each component percentage composition described in example is weight percentage.
Embodiment 1：The Pesticidal combination is suspending agent, and each component percentage composition is respectively：
Active ingredient（A +B）5~80%,
Dispersant 5~20%,
Antifreezing agent 1~5%,
Thickener 0.1~2%,
Defoamer 0.1~2%,
PH value regulator 0.1~5%,
Water surplus.
Concrete operation step is：First other auxiliary agents are mixed, shear-mixed is uniform in cutter, then add effectively into
Divide A and active ingredient B, 2~3h is ground in ball crusher, makes a diameter in below 5mm, you can Insecticidal combinations of the present invention are made
Thing aqueous suspension formulations.
Embodiment 2：The Pesticidal combination is aqueous emulsion, and each component percentage composition is respectively：
Active ingredient（A+B）5~80%,
Emulsifying agent 5~30%,
Solvent 5~15%,
Stabilizer 3~15%,
Antifreezing agent 2~5%,
Defoamer 0.2~5%,
Thickener 0.2~2%,
Water surplus.
Concrete operation step is：First effective constituents A and active ingredient B, solvent, emulsifying agent are mixed, are dissolved into
For uniform oil phase.Part water and other auxiliary agents are mixed again, dissolving turns into uniform aqueous phase.Then in a kettle.
Oil phase is added into aqueous phase while high-speed stirred, slowly adds water to and reaches phase inversion point, high speed shear is carried out afterwards, and add residue
Water, shear about 30min, you can be made Pesticidal combination water and milk agent formulation of the present invention.
Embodiment 3：The Pesticidal combination is microemulsion, and each component percentage composition is respectively：
Active ingredient（A+B）5~80%,
Emulsifying agent 10~30%,
Antifreezing agent 2~10%,
Stabilizer 2~10%,
Solvent 20~50%,
Water surplus.
Concrete operation step is：Effective constituents A and active ingredient B are completely dissolved with solvent and cosolvent, then added again
Enter other auxiliary agents, be well mixed, water be eventually adding, after being sufficiently stirred for, you can Pesticidal combination microemulsion formulation of the present invention is made.
Embodiment 4：The Pesticidal combination is wettable powder, and each component percentage composition is respectively：
Active ingredient（A+B）5~80%,
Dispersant 5~10%,
Wetting agent 2~5%,
Filler surplus.
Concrete operation step is：Effective constituents A and active ingredient B, other auxiliary agents and filler are mixed, in stirred tank
It is sufficiently stirred for, is well mixed after being crushed through airslide disintegrating mill, you can Pesticidal combination wettable powder formulation of the present invention is made.
Embodiment 5：The Pesticidal combination is water dispersible granules, and each component percentage composition is respectively：
Active ingredient（A+B）5~80%,
Dispersant 5~10%,
Wetting agent 2~10%,
Disintegrant 1~5%,
Filler surplus.
Concrete operation step is：Effective constituents A and active ingredient B, other auxiliary agents and filler are well mixed, ultra micro is used
Airslide disintegrating mill is crushed, and is added after kneading after being granulated in fluidized-bed granulation dryer, drying, sieve, you can obtained
Invention Pesticidal combination water-dispersible grain agent formulation.
Embodiment 6：The Pesticidal combination is missible oil, and each component percentage composition is respectively：
Active ingredient（A+B）5~80%,
Emulsifying agent 10~30%,
Solvent 20~50%,
Synergist 1~3%.
Concrete operation step is：Fully dissolve, then add other after effective constituents A and active ingredient B are added into solvent
Turn into the oily liquids of transparent and homogeneous after being stirred after auxiliary agent, you can Pesticidal combination cream preparation of the present invention is made.
Auxiliary agent is selected from as described below in above formulation.
Solvent can be water, DMF, methanol, ethanol, ethylene glycol, propane diols, acetone, cyclohexanone, pyrrole
One or more in pyrrolidone, toluene, dimethylbenzene, ethyl acetate, dimethylformamide, vegetable oil, petroleum ether, acetonitrile etc..
Emulsifying agent can be tri ethanol ammonium salt, APES formaldehyde condensation product, alkylbenzene naphthalene sulfonate, alkyl
Phenol polyethenoxy ether phosphate, diphenyl phenol polyethenoxy polyethenoxy ether, styrenated phenol APEO, diphenyl phenol polyoxy
In ethene polyoxy formaldehyde condensation products, agriculture breast 300#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, TWEEN Series, AEO series etc.
It is one or more of.
Wetting agent can be sodium sulphate, sldium lauryl sulfate, lignosulfonates, APES phosphate,
Petroleum sodium sulfonate, alkylnaphthalene sulfonate, fatty acid ester sulfate, APES, AEO, gleditsia sinensis
One or more in powder, tea seed cake powder, silkworm excrement etc..
Disintegrant can be one in sodium acid carbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
Plant or several.
Dispersant can be methylcellulose, polycarboxylate, sodium methylene bis-naphthalene sulfonate, sodium lignin sulfonate, fatty acyl
Amine N methyl taurine sodium salt, APES sulfate, lignosulfite, fatty acid ester sulfate, alkyl
One or more in naphthalene sulfonate, APES, AEO etc..
Thickener can be polyvinyl alcohol, polyvinyl acetate, xanthans, gelatin, guar gum, aluminium-magnesium silicate, phenolic resin,
One or more in hydroxymethyl cellulose, sodium alginate, gypsum etc..
During pH adjusting agent can be ammonium hydroxide, potassium hydroxide, NaOH, hydrochloric acid, acetic acid, citric acid, phosphoric acid etc.
It is one or more of.
Synergist can be organosilicon, thiophene ketone, azone, double to kill etc. in it is one or more of.
Stabilizer can be with BHT, triethanolamine, tributyl phosphate, xylitol, mannitol, pentaerythrite, sodium citrate etc.
One or more.
Defoamer can be the one or more in silicone compound, epoxidized soybean oil, methanol, silicone oil etc..
Antifreezing agent can be one or more in glycerine, ethylene glycol, propane diols, sorbierite, polyethylene glycol etc..
Carrier can be one in kaolin, diatomite, bentonite, white carbon, clay, talcum powder, quartz sand, starch etc.
Plant or several.
（Two）The indoor biological determination of activity of the present composition and field efficacy checking.
1st, the indoor joint toxicity measuring of etoxazole and Hexythiazox to panonychus citri.
Test medicine uses 93% etoxazole active compound and 97% Hexythiazox active compound.
Test worm is to gather the panonychus citri deutonymph through the generation of indoor feeding 3 from citrus orchard.
Test method uses leaf butterfly spray-on process（With reference to《The experiment of NY/T 1154.13-2008 farm-chemical indoor determinations is accurate
Then parts of insecticide the 13rd：Leaf butterfly spray-on process》）.Concrete operation method is as follows：
Each single dose is set into 5 different concentration gradients with Mixed Pharmacy（On the basis of pilot study result, citrus is complete
The pawl mite deutonymph death rate is set in the range of 5%~90% by geometric progression）.
The consistent Citrus leaf of growth is chosen, leaf butterfly is made with card punch, a wet sponge block is placed in culture dish, thereon
Foliation butterfly on filter paper, filter paper is put, 2 pieces of leaf butterflies are put per ware, panonychus citri deutonymph inoculation that select health, that Individual Size is consistent
Onto leaf butterfly, 20 are inoculated with per leaf butterfly.
The culture dish for being connected to leaf butterfly is placed under potter spray towers, sprayed under 50PSI pressure, spray amount is 1ml, is sunk
Culture dish is taken out after drop 1min, then treated culture dish is put into 12H/12H illumination boxs and cultivated, 48h checks dead
Mite number, calculates the death rate.Often processing sets 4 repetitions, and sets clear water blank control processing.
Statistical analysis is carried out with DPS statistical analysis softwares, the LC of each medicament is calculated50, to evaluate the acaricidal activity of each medicament.
And the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun（CTC values.）
Survey toxicity index（ATI）=（Standard agent LC50/ reagent agent LC50）×100.
Theoretical toxicity index（TTI）A percentage composition+B medicament toxicity index in=A medicament toxicity index × mixture ×
B percentage composition in mixture.
Co-toxicity coefficient（CTC）=[mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）] ×100.
The criteria for classifying is acted on according to NY/T11547.7-2006 insecticide combinations：Co-toxicity coefficient（CTC）>=120 show as
Synergistic effect；Co-toxicity coefficient（CTC）≤ 80 show as antagonism；80 ＜ co-toxicity coefficients（CTC）＜ 120, which shows as being added, to be made
With.
As it can be seen from table 1 etoxazole and Hexythiazox are in mixed ratio 20:1~1:20（By weight）In the range of compound
When, co-toxicity coefficient（CTC）120 are all higher than, obvious synergistic function is shown to panonychus citri deutonymph, especially existed
10:1~1:1（By weight）In the range of compound, synergistic function becomes apparent, co-toxicity coefficient（CTC）More than 150,
It can be seen that etoxazole and Hexythiazox compounding have reasonability and feasibility.
The indoor joint toxicity measuring of table 1, etoxazole and Hexythiazox to panonychus citri deutonymph.
2nd, etoxazole and Hexythiazox compound the field control effectiveness test to panonychus citri.
3d, 7d, 14d, 30d after insect population, medicine are investigated before dispenser and investigates residual mite number living respectively, is looked into during investigation per cell
2 plants, every plant is looked into 5 blades respectively by the orientation of the four corners of the world 4, looks into 40 blades altogether per cell, is recorded mite number living, is calculated preventing and treating
Effect.Prevention effect computational methods are as follows：Prevention effect（%）=（1- CK1×Pt1/CK2×Pt2）×100.Wherein：CK1 generations
Insect population number before the medicine of table check plot；Pt1 represents insect population number after treatment region medicine；CK2 represents insect population number after the medicine of check plot；Pt2 representative office
Manage insect population number before area's medicine.
Table 2,20% etoxazole hexythiazox suspension agent prevent and treat the result of the test of panonychus citri.
20% etoxazole Hexythiazox as can be seen from Table 2（10:10）Suspending agent using 6000~7000 times of 3d, 7d, 14d,
The preventive effect of panonychus citri is intended to use 5000 times and 5% thiophene mite apparently higher than the etoxazole suspending agent single dose of the same period 11% after 30d
Ketone missible oil single dose uses 2000 times, illustrates that etoxazole and Hexythiazox compounding can be improved to mandarin orange compared with two kinds of single doses are used alone
Citrus red mite preventive effect, while 30d preventive effects illustrate there is good lasting effect, this is not found during experiment still up to more than 80% after medicine
Compound drug produces poisoning to citrus.
3rd, etoxazole and Hexythiazox compound the field control effectiveness test to cotton Tetranychus cinnabarinus.
3d, 7d, 14d, 30d after insect population, medicine are investigated before dispenser and investigates residual mite number living respectively, is looked into during investigation per cell
2 plants, every plant is looked into 5 blades respectively by the orientation of the four corners of the world 4, and each cell looks into 40 blades altogether, records mite number living, calculates anti-
Control effect.Prevention effect computational methods are as follows：
Prevention effect（%）=（1- CK1×Pt1/CK2×Pt2）×100.Wherein： CK1Represent insect population number before the medicine of check plot；
Pt1Represent insect population number after treatment region medicine；CK2 represents insect population number after the medicine of check plot；Pt2 represents insect population number before treatment region medicine.
Table 3,15% etoxazole Hexythiazox aqueous emulsion preventing and treating cotton Tetranychus cinnabarinus result of the test.
15% etoxazole Hexythiazox as can be seen from Table 3（5:10）Aqueous emulsion using 4000~5000 times of 3d, 7d, 14d,
The preventive effect of cotton Tetranychus cinnabarinus is intended to use 5000 times and 5% thiophene apparently higher than the etoxazole suspending agent single dose of the same period 11% after 30d
Mite ketone missible oil single dose uses 2000 times, illustrate that etoxazole and Hexythiazox compounding can be improved pair compared with the exclusive use of two kinds of single doses
Cotton Tetranychus cinnabarinus preventive effect, while 30d preventive effects illustrate there is good lasting effect, do not sent out during experiment still up to more than 80% after medicine
Now the compound drug produces poisoning to cotton.
In summary, the present invention uses two kinds of active components for etoxazole and the complex composition of Hexythiazox, and existing
Unitary agent is compared, not only with obvious synergistic effect, and also with good miticidal effect, the lasting period is long, and crops are pacified
Entirely, the drug-fast generation of evil mite can be slowed down, be worth the popularization and application in agricultural production.
Claims (4)
1. a kind of Etoxazole-hexythiazomiticide miticide composition, it is characterised in that active ingredient is etoxazole and Hexythiazox；Etoxazole
It is 20 with the weight ratio of Hexythiazox in the composition:1~1:20.
2. Etoxazole-hexythiazomiticide miticide composition according to claim 1, it is characterised in that：Etoxazole and Hexythiazox exist
Gross weight percentage composition in composition is 5~80%.
3. Etoxazole-hexythiazomiticide miticide composition according to claim 1, it is characterised in that：In the miticide composition
The auxiliary element also commonly used containing pesticidal preparations, so as to which the formulation products for being adapted to use in agricultural production are made.
4. Etoxazole-hexythiazomiticide miticide composition according to claim 1, it is characterised in that：The miticide composition
Formulation is one kind in suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wettable powder or missible oil.
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| EP2484210A1 (en) * | 2011-02-08 | 2012-08-08 | Basf Se | Pesticidal compositions |
| CN102308841A (en) * | 2011-04-29 | 2012-01-11 | 陕西韦尔奇作物保护有限公司 | Pesticide composition containing etoxazole |
| CN102228055A (en) * | 2011-05-06 | 2011-11-02 | 陕西韦尔奇作物保护有限公司 | Pesticide composite containing fenazaquin |
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