CN102484991B - Synergic farm pesticide composition of ivermectin and tea saponin - Google Patents
Synergic farm pesticide composition of ivermectin and tea saponin Download PDFInfo
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- CN102484991B CN102484991B CN201010575650.0A CN201010575650A CN102484991B CN 102484991 B CN102484991 B CN 102484991B CN 201010575650 A CN201010575650 A CN 201010575650A CN 102484991 B CN102484991 B CN 102484991B
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- ivermectin
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Abstract
The invention which belongs to the technical field of farm pesticides relates to a synergic farm pesticide composition of ivermectin and tea saponin. The farm pesticide composition is characterized in that: the tea saponin which is one active component of the farm pesticide composition and has been singly used as a pure traditional surfactant is combined with ivermectin and synergically performs the pest and mite killing effect with ivermectin, wherein the synergism and the spectrum spreading are reached when the weight ratio of ivermectin to the tea saponin is 1:0.01-1:100, preferably 1:0.1-1:50, and most preferably 1:1-10. The farm pesticide composition can be applied to the control of various pests on agricultural crops and garden crops.
Description
Technical field
The invention belongs to technical field of pesticide, the active component that it is characterized in that relating to a kind of composition pesticide of synergy, particularly said composition is ivermectin on the one hand, is Tea Saponin on the other hand.
Background technology
Ivermectin (Ivermectin) is taking Avermectin as lead compound, by two key hydrogenation, and structure optimization and the novel synthetic pesticide succeeded in developing.As the structure optimization product of agricultural antibiotic, compared with parent Avermectin, not only retain its expelling parasite and killed full activity, and safety is higher, be difficult for producing resistance, for the production of vegetables, fruit, cotton etc. provides efficient a, high security and the agricultural insecticide miticide good with Environmental compatibility.Ivermectin has stomach toxicity and action of contace poison, and has horizontal infiltration conduction, and insect, mite class and nematode are killed to effect.
In pesticidal preparations, use rightly synergist; this is efficient to adequately protect for the usage amount that reduces to greatest extent ivermectin active ingredient, high security and the pesticide species good with Environmental compatibility; extend its service life; and the while does not affect the drug effect of preparation, it is problem demanding prompt solution in the sustainable development of ivermectin agricultural chemicals.
Tea Saponin (Tea saponin, TS) have another name called tea saponin, tea saponin, tea saponarin, it is a kind of well behaved natural surfactant, not only there is good emulsification, foaming, dispersion, infiltration, wetting isoreactivity effect, but also there is anti-inflammatory, pain relieving, sterilization, the pharmacological action such as antipruritic.Tea Saponin is the good auxiliary agent of aqua or soluble powder agricultural chemicals, plays the synergistic effect to agricultural chemicals.Tea Saponin can be degraded automatically, and it can not exert an influence to the chemical property of agricultural chemicals in decomposable process.Tea Saponin can be used as pesticide activity component and uses, but Tea Saponin quick-acting is poor, application dosage is large, and result of use is bad separately.
In the present invention, Tea Saponin is using be used to study the common malicious synergistic effect of itself and another active ingredient ivermectin as one of pesticide activity component, for excavating the new purposes of Tea Saponin and utilizing efficiently and safely ivermectin agricultural chemicals that new outlet is provided.Have no patent report taking ivermectin and Tea Saponin as the synergetic pesticide composition of active component.
Summary of the invention
The object of this invention is to provide a kind of ivermectin of technical field of pesticide and the synergetic pesticide composition of Tea Saponin, to a kind of efficient, low toxicity, wide spectrum being provided and being difficult for causing drug-fast environmentally friendly composition pesticide.
Composition pesticide provided by the invention, it is characterized in that: the mass ratio of active ingredient ivermectin and Tea Saponin is 1: 0.01～1: 100, be preferably 1: 0.1～1: 50, the best is 1: 1～1: 10, all the other are insecticides adjuvant, are mixed with and are applicable in actual applications the upper any preparation using of agricultural according to method known to those skilled in the art processing.Described auxiliary agent specifically needs to determine according to preparation.
Described Tea Saponin can be extract, Tea Saponin sterling or its mixture and preparation thereof.
Good effect of the present invention is: widen control of insect spectrum, a drug can be held concurrently and be treated two or more simultaneous insects; Complementary mechanism of action strengthens the opening up of liquid, wetting action in Tea Saponin desinsection, and ivermectin is had significant synergies, and reduces its usage amount, increases the service life; The use of natural source agricultural chemicals Tea Saponin, in composition, the while can be served as the role of surfactant, greatly reduces the interpolation of other surfactant, more environmental protection.
Embodiment
In order to understand better essence of the present invention, slightly give an actual example to further illustrate the preparation of the present composition and toxic effect application altogether below, but content of the present invention is not limited to this.
Embodiment 1: preparation 20% ivermectin Tea Saponin microemulsion
Insecticidal active ingredient percentage by weight (%) is: ivermectin 5.0, Tea Saponin 15.0;
The each composition percentage by weight of auxiliary agent (%) is: emulsifier: polyoxyethylene alkyl amine is 10.0; Solvent: Solvesso100 is 15.0; Cosolvent: 1-METHYLPYRROLIDONE is 5.0; Antifreezing agent: glycerine is 2.0; Surplus deionized water.
By proportioning, ivermectin is dissolved in solvent, Tea Saponin is soluble in water, emulsifier is joined in ivermectin solution, stir, add all the other auxiliary agents, the Tea Saponin aqueous solution, put into and in homogenizer, give strong mixing homogenize and get final product.
Embodiment 2: preparation 10.5% ivermectin Tea Saponin aqueous emulsion
Insecticidal active ingredient percentage by weight (%) is: ivermectin 3.5, Tea Saponin 7.0;
The each composition percentage by weight of auxiliary agent (%) is: emulsifier: TX-10 is 4.5; Thickener: gum Arabic is 2.0, xanthans is 1.0; Solvent: diesel oil is 11.2.0; Antifreezing agent: sorbic acid is 5.0; Defoamer: cocoa butter EO-PO polymer is 0.2; Preservative: potassium sorbate is 2.0; Surplus deionized water.
By proportioning, ivermectin and the former medicine of Tea Saponin are dissolved in solvent, emulsifier, cosolvent are joined in ivermectin and Tea Saponin solution, stir, said mixture is slowly added to the water, fully stirring and get final product.
Embodiment 3: preparation 11% ivermectin Tea Saponin suspending agent
Insecticidal active ingredient percentage by weight (%) is: ivermectin 1.0, Tea Saponin 10.0;
The each composition percentage by weight of auxiliary agent (%) is: wetting dispersing agent: WD-C is 11.0; Thickener: polyvinyl pyrrolidone is 1.2, xanthan gum is 1.0; Defoamer: organic silicone is 1.5; Antifreezing agent: glycerine is 5.6; Preservative: sodium citrate is 0.5; Surplus deionized water.
By proportioning, ivermectin and the former medicine of Tea Saponin are pulverized, added various auxiliary agents and water except thickener, put into together high-shear emulsion machine and mix, add thickener further to mix, grind through skin grinder, after microscopy is qualified and get final product.
Embodiment 4: preparation 12.5% ivermectin Tea Saponin wetting powder
Insecticidal active ingredient percentage by weight (%) is: ivermectin is 2.5, and Tea Saponin is 10.0;
The each composition percentage by weight of auxiliary agent (%) is: dispersant: alkylsulfonate 20.0; Balance carriers: kaolin.
By proportioning, ivermectin and the former medicine of Tea Saponin are carried out joining in blender after air-flow crushing, in blender, add dispersant, filler respectively by proportioning, stir and get final product.
Embodiment 5: preparation 80.8% ivermectin Tea Saponin water-dispersible granules
Insecticidal active ingredient percentage by weight (%) is: ivermectin 80.0, Tea Saponin 0.8;
The each composition percentage by weight of auxiliary agent (%) is: wetting agent: Lx-C is 3.6; Disintegrant: anhydrous sodium sulfate is 2.5; Dispersant: NNO is 3.0, balance carriers: atlapulgite.
See that by formula ivermectin and the former medicine of Tea Saponin and other auxiliary material one reinstate air-flow crushing etc. and carry out the fine pulverizing of dry type, obtain after the wetting powder of powdery, then by this water-dispersion type granula granulation and get final product.
Embodiment 6: preparation 10.1% ivermectin Tea Saponin aqua
Insecticidal active ingredient percentage by weight (%) is: ivermectin 0.1, Tea Saponin 10.0;
The each composition percentage by weight of auxiliary agent (%) is: surfactant: neopelex is 5.0, and Sodium Benzoate is 1.0, surplus deionized water.
Embodiment 7: preparation 11% ivermectin Tea Saponin soluble liquid
Insecticidal active ingredient percentage by weight (%) is: ivermectin 0.65, Tea Saponin 10.35;
The each composition percentage by weight of auxiliary agent (%) is: surfactant: anhydrous sorbitol APEO 13.0; Antifreezing agent: glycerine 2.5; Solubilizer: ethyl acetate 15.0; Solvent is mended to 100.
With indoor joint toxicity measuring example, the synergistic effect of the present composition is described below, but the present invention is not limited to following concrete test example in actual applications.
The indoor virulence test that the present invention carries out the synergistic composition of ivermectin and Tea Saponin has adopted conventional method, and data are calculated and processing is carried out as follows:
By the each lethality of processing of Abbott formula correction, with DPS software calculating LC
50and virulence regression equation.Adopt the abundant method of Sun Yun to obtain the co-toxicity coefficient (CTC) of each mixed ratio with reference to NY/T1154.7-2006, and evaluate the two mixed synergistic effect.
Criterion: CTC≤80, show as antagonism; CTC:80～120, show as summation action; CTC >=120, show as synergistic effect.
The single dose of test example 1 ivermectin and Tea Saponin and the indoor virulence test of composition to panonychus citri thereof
Examination worm: panonychus citri (Panonychus citri Me Gregor)
Test method: with the female one-tenth mite of writing brush picking health, its back is bonded on the slide of double faced adhesive tape, every sticky 3 row, totally 25 left and right, then microscopy is removed dead polypide.The slide one end that is stained with mite is placed in to the liquid having prepared and soaks 5s, after taking-up, suck unnecessary liquid with blotting paper, contrast clear water processing, does not process and repeats 4 times.Processing is placed in the porcelain basin under moisturizing condition, and wet gauze on upper face shield checks each processing mite number anyway under light microscope after 24h.
Result of the test is in table 1:
The virulence result (24h) of table 1 ivermectin proportionings different from Tea Saponin to panonychus citri
*a is ivermectin, and B is Tea Saponin
As seen from Table 1, the composition of ivermectin and Tea Saponin is all greater than the co-toxicity coefficient of panonychus citri or approaches 120 under each proportioning, the each proportioning mixing that shows ivermectin and Tea Saponin at least produces summation action, in for examination proportioning, proportioning ivermectin: Tea Saponin=1: the co-toxicity coefficient maximum of 5 pairs of panonychus citris, its value is 220.35.
The single dose of test example 2 ivermectins and Tea Saponin and the indoor virulence test of composition to rice leaf roller thereof
Examination worm: rice leaf roller (Cnaphalocrocis medialis (Guenee))
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ".Gather the female moth egg of rice leaf roller from field.Female worm is released in cylindrical shrouding, interior wall liner coating of wax paper, outer cover black cloth, feeds and raises 10% hydromel.Cut pieces of an egg to put moisturizing in culture dish with paraffin paper next day, after hatching, raises with the fresh rice leaf of cultivating.Insectary temperature (28 ± 1) DEG C, the photoperiod 16 (L): 8 (D).Choose 2 instar larvaes of growth uniformity, the culture dish of 12 centimetres of the diameters of fresh rice leaf is put in access.Every ware is put into 10 rice leaf roller, is often treated to 5 wares.Spray under 50PSI pressure with Potter spray tower, spray a culture dish at every turn, 3 milliliters of every ware spraying liquids, put into 25 DEG C after having sprayed rear rapid airing rice leaf, in 12H/12H illumination box, cultivate, and within 48 hours, check dead borer population, calculate lethality.Blank spray equivalent clear water.Each processing arranges 6 concentration.
Result of the test is in table 2:
The virulence result of table 2 ivermectin proportionings different from Tea Saponin to rice leaf roller 2 instar larvaes
*a is ivermectin, and B is Tea Saponin
As seen from Table 2, the composition of ivermectin and Tea Saponin is all greater than or approaches 120 the co-toxicity coefficient of rice leaf roller 2 instar larvaes under each proportioning, the each proportioning mixing that shows ivermectin and Tea Saponin at least produces summation action, in for examination proportioning, proportioning ivermectin: Tea Saponin=1: the co-toxicity coefficient maximum of 6 pairs of rice leaf roller 2 instar larvaes, its value is 238.56.
Claims (6)
1. a composition pesticide, is characterized in that the ivermectin and the Tea Saponin that contain synergy effective dose, and the weight ratio of ivermectin and Tea Saponin is 1: 0.05～1: 50.
2. according to the composition pesticide of claim 1, it is characterized in that the weight ratio of ivermectin and Tea Saponin is preferably 1: 1～1: 50.
3. according to the composition pesticide of claim 1, the weight ratio the best that it is characterized in that ivermectin and Tea Saponin is 1: 1～1: 10.
4. according to the composition pesticide described in claim 1 or 2 or 3, it is characterized in that Tea Saponin can be extract, Tea Saponin sterling or its mixture.
5. the formulation using in the arbitrarily applicable agricultural that composition pesticide according to claim 1 is processed in actual production and application.
6. the application of composition pesticide according to claim 1 in agricultural and horticultural crop PCO.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010575650.0A CN102484991B (en) | 2010-12-02 | 2010-12-02 | Synergic farm pesticide composition of ivermectin and tea saponin |
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| CN201010575650.0A CN102484991B (en) | 2010-12-02 | 2010-12-02 | Synergic farm pesticide composition of ivermectin and tea saponin |
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| CN102484991A CN102484991A (en) | 2012-06-06 |
| CN102484991B true CN102484991B (en) | 2014-11-12 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102870790A (en) * | 2012-09-13 | 2013-01-16 | 青岛文创科技有限公司 | Synergistic pesticide composition of ivermectin and chitosan oligosaccharide |
| CA3015639A1 (en) * | 2016-03-09 | 2017-09-14 | Technion Research And Development Foundation Ltd. | Liposomal formulations and methods of using same in agriculture |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437846A (en) * | 2002-11-29 | 2003-08-27 | 金中北 | Aqueous farm chemical with various insecticidal activity |
| CN101218916A (en) * | 2007-12-18 | 2008-07-16 | 华南农业大学 | Mix pesticide preparation of tubatoxin and antibiotic insecticide |
| CN101720766A (en) * | 2009-12-29 | 2010-06-09 | 华南农业大学 | Insecticidal composition of tea saponin and pleocidin |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437846A (en) * | 2002-11-29 | 2003-08-27 | 金中北 | Aqueous farm chemical with various insecticidal activity |
| CN101218916A (en) * | 2007-12-18 | 2008-07-16 | 华南农业大学 | Mix pesticide preparation of tubatoxin and antibiotic insecticide |
| CN101720766A (en) * | 2009-12-29 | 2010-06-09 | 华南农业大学 | Insecticidal composition of tea saponin and pleocidin |
Non-Patent Citations (3)
| Title |
|---|
| Control of citrus postharvest green and blue mold and sour rot by tea saponin combined with imazalil and prochloraz;Hao Weining,et al;《Postharvest Biology and Technology》;20100430;第56卷(第1期);第39-43页 * |
| Hao Weining,et al.Control of citrus postharvest green and blue mold and sour rot by tea saponin combined with imazalil and prochloraz.《Postharvest Biology and Technology》.2010,第56卷(第1期),第39-43页. * |
| 夏春华，等.茶皂素在农药工业中应用研究进展.《茶叶科学》.2000,第20卷(第2期),第82-88页. * |
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Granted publication date: 20141112 Termination date: 20211202 |