CN104522036B - Insecticidal composition used for preventing and controlling lepidoptera pests and homoptera pests - Google Patents
Insecticidal composition used for preventing and controlling lepidoptera pests and homoptera pests Download PDFInfo
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- CN104522036B CN104522036B CN201410799339.2A CN201410799339A CN104522036B CN 104522036 B CN104522036 B CN 104522036B CN 201410799339 A CN201410799339 A CN 201410799339A CN 104522036 B CN104522036 B CN 104522036B
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Abstract
The invention discloses an insecticidal composition containing effective insecticidal components such as HNPC-A8008 and dinotefuran and used for preventing and controlling lepidoptera pests and homoptera pests. The weight ratio of the HNPC-A8008 to the dinotefuran is (1 to 120)-(120 to 1); the total mass fraction percentage of the HNPC-A8008 and the dinotefuran in the composition is 10%-70%. The insecticidal composition comprises the following dose forms: a suspending agent or a water emulsion, a microemulsion, wettable powder and a water dispersible granule. A plurality of indoor and outdoor tests prove that a mixture of the HNPC-A8008 and the dinotefuran has an obvious synergistic effect, multi-aspect common actions to the pests are achieved, prevention and control objects are expanded, the prevention and controlling effects are improved, the pests are effectively prevented and controlled, meanwhile, the resistance risk of the pests to the dinotefuran is reduced, the use filed of the HNPC-A8008 is broadened, the consumption of the insecticidal composition in a field is reduced, the agricultural cost is lowered, and the environmental pollution caused by the insecticidal composition is reduced; the insecticidal composition has excellent effects to the prevention and the controlling of the lepidoptera pests and the homoptera pests of greenstuffs, rice, fruit trees and flower crops.
Description
Technical field
The present invention relates to a kind of Pesticidal combination, contained effective ingredient is (e) -5- (3- chlorallyl) amino -1- (2,6-
Dichlor-4-trifluoromethyl) phenyl -4- trifluoromethyl sulfinyl pyrazole -3- nitrile (test code number be hnpc-a8008) and furan worm
Amine, for preventing and treating Lepidoptera and the homoptera pest of vegetable, Oryza sativa L., fruit tree and flower crop.
Background technology
Chemical name is (e) -5- (3- chlorallyl) amino -1- (2,6- dichlor-4-trifluoromethyl) phenyl -4- fluoroform
The compound ((test code number is hnpc-a8008)) of base sulfinyl pyrazoles -3- nitrile, is Hunan Chemical Research Institute to reduce
Ethiprole medicament fat-soluble, by modifying for chemical structure design synthesis the new pyrazole compound with insecticidal activity,
New chemical constitution improves the adverse side effect to non-target organism for this kind of compound.The chemical structural formula of hnpc-a8008 is shown in
Following formula.
Hnpc-a8008 can be used for the preventing and treating of the various crop insect such as Oryza sativa L., vegetable, Cotton Gossypii, Radix Betae, such as beet armyworm, tiltedly
Autographa spp, striped rice borer, yellow rice borer, rice leaf roller, Pieris rapae, aphid, planthopper etc., its model of action, based on stomach toxicity, has
There is certain contact toxicity, systemic activity is weaker, quick-acting is good；This medicament is mainly used in numerous elytrum such as Oryza sativa L., fruit tree, vegetable
Mesh Pest control.
MTI-446 (dinotefuran, d), belongs to third generation nicotinic insecticide, this medicament have tag, stomach toxicity and root
Portion's absorbability is strong, quick-acting high, lasting period length (3-4 week) the features such as.The chemical structural formula of MTI-446 sees below formula.
MTI-446 mainly acts on insecticide neuronal transmission system, so that insect is benumbed thus playing insecticidal action.This medicament kills
Worm spectrum is wide, is mainly used in the Pest control such as numerous crop Homoptera such as Oryza sativa L., fruit tree, vegetable, coleoptera.Due to nicotine in recent years
The large area of class medicament uses, and homoptera pest has created different degrees of Drug resistance, field using dosage to such medicament
Constantly raise, use cost also more and more higher.Therefore explore effective compound scheme the Drug resistance of solution MTI-446, cost are asked
Topic has positive meaning.
Not yet there are hnpc-a8008 and dinotefuran mixed report at present.
Content of the invention
The invention aims to reducing the drug resistance risk to MTI-446 for the insect, that widens hnpc-a8008 uses neck
Domain, reaches from many aspects to insect collective effect, expanding prevention object, raising prevention effect, effective pest control, reduces simultaneously
Medicament, in the using dosage in field, reduces agricultural cost, reduces the purpose of the pollution to environment for the medicament, the Pesticidal combination providing
It is with (e) -5- (3- chlorallyl) amino -1- (2,6- dichlor-4-trifluoromethyl) phenyl -4- trifluoromethyl sulphinyl base pyrrole
Azoles -3- nitrile (test code number hnpc-a8008) and the Pesticidal combination that MTI-446 is effective insecticidal constituent.It is to use sun＆
Johnson (1960) co-toxicity coefficient method (ctc) filters out the Pesticidal combination with hnpc-a8008 and MTI-446 as effective ingredient.
In the compositionss of the present invention, the weight of effective ingredient hnpc-a8008 and MTI-446 is than for 1:120～120:1,
Hnpc-a8008 accounts for the 10%～70% of composition total weight with the weight sum of MTI-446.
The dosage form of the present composition includes suspending agent or aqueous emulsion, microemulsion, wettable powder, water dispersible granules.Press
Process according to formulations of pesticide Conventional processing methods.
During the dosage form suspending agent of compositionss, the weight percentage of each component is hnpc-a8008 0.1～20%；Furan worm
Amine 0.1～20%；Emulsifying agent 5～15%；Solvent 5～20%；Wetting agent 3～10%；Dispersant 3～10%；Antifreezing agent 1～
5%；Thickening agent 0.1～2%；Defoamer 0.1～1%；Deionized water adds to 100%.
During the dosage form aqueous emulsion of compositionss, the weight percentage of each component is: hnpc-a8008 0.1～25%；Furan worm
Amine 0.1～25%；Emulsifying agent 5～25%；Solvent 5～15%；Stabilizer 1～10%；Antifreezing agent 1～5%；Thickening agent 0.1～
2%；Deionized water adds to 100%；
During the dosage form microemulsion of compositionss, the weight percentage of each component is: hnpc-a8008 0.1～20%；Furan worm
Amine 0.1～20%；Solvent 10～30%；Emulsifying agent 5～30%；Antifreezing agent 1～5%；Stabilizer 1～10%；Deionized water adds
To 100%；
During the dosage form wettable powder of compositionss, the weight percentage of each component is: hnpc-a8008 10～60%；
MTI-446 10～60%；Dispersant 5～10%；Wetting agent 5～10%；Filler adds to 100%；
During the dosage form water dispersible granules of compositionss, the weight percentage of each component is: hnpc-a8008 1～69%；Furan
Worm amine 1～69%；Dispersant 5～15%；Wetting agent 5～10%；Disintegrating agent 1～8%；Filler adds to 100%.
Described wetting agent is sodium lauryl sulphate, dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate, mahogany acid
The mixing of one or more of sodium, wetting and penetrating agent f, pull open powder bx, tea seed cake powder, spaonin powder, spaonin powder etc.；
Described dispersant is lignosulfonates, polycarboxylate, alkylphenol polyoxyethylene sulfate, alkyl benzene sulphonate
In calcium salt, fatty acid ester sulfate, alkylphenol polyoxyethylene, sodium metnylene bis-naphthalene sulfonate, fatty alcohol-polyoxyethylene ether etc.
The mixing of one or more；
Described antifreezing agent is the mixing of one or more in glycerol, propylene glycol, diethylene glycol, Polyethylene Glycol etc.；
Described thickening agent is polyvinyl alcohol, polyvinyl acetate, xanthan gum, gelatin, Radix Acaciae senegalis, polyvinyl pyrrole
The mixing of one or more of alkanone, aluminium-magnesium silicate, phenolic resin, hydroxymethyl cellulose, sodium alginate etc.；
Described defoamer is silicone oil, silicone compound, c10-20Saturated fat acids compound, c8-10The one of fatty alcohol
Plant or several mixing；
Described solvent is deionized water, methanol, ethanol, butanol, propylene glycol, glycerol, Polyethylene Glycol, Ketohexamethylene, pyrrole
The mixing of one or more of pyrrolidone, ethyl acetate；
Described emulsifying agent is agriculture breast 500#I.e. alkyl benzene calcium sulfonate, agriculture breast 400#I.e. benzyl dimethyl phenol polyoxyethyl ether,
Nongru-700#I.e. alkylphenol-formaldehyde resin polyoxyethyl ether, agriculture breast 1600#I.e. phenethyl phenol polyoxyethanyl polypropylene-base ether, benzene second
Alkene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, epoxy ethane-epoxy propane block are altogether
Polymers, op series be NPE, by series be castor oil polyoxyethylene ether, Span series be that sorbitol anhydride list is hard
Fat acid, TWEEN Series be anhydrous sorbitol fat acid ester APEO, aeo series be fatty alcohol-polyoxyethylene ether one of i.e.
Or several mixing；
Described stabilizer is one of xylitol, Mannitol, tetramethylolmethane, triphenyl phosphite, sodium citrate etc.
Or several mixing；
Described filler is precipitated calcium carbonate, potter's clay, Kaolin, kieselguhr, bentonite, white carbon, Pulvis Talci, quartz sand
Deng one or more of mixing；
Described disintegrating agent is in sodium bicarbonate, magnesium chloride, aluminum chloride, sodium chloride, carbamide, ammonium sulfate, bentonite etc.
The mixing of one or more.
Present composition great number of indoor and outdoor experiments show that after being compounded, hnpc-a8008 and dinotefuran mixed there is obvious association
Same potentiation, has reached from many aspects to insect collective effect, expanding prevention object, raising prevention effect, effectively preventing and treating evil
Worm acts on, and reduces the drug resistance risk to MTI-446 for the insect simultaneously, has widened the use field of hnpc-a8008, reduced medicament
Using dosage in field and agricultural cost, reduce the pollution to environment for the medicament, make in preventing and treating vegetable, Oryza sativa L., fruit tree and flowers
Tall and erect effect is had on the Lepidoptera of thing and homoptera pest.
Specific embodiment
Essence for a better understanding of the present invention, with reference to embodiment, the invention will be further described, but never
It is limited to following embodiments.Mentioned content not limitation of the invention in embodiment, the work such as temperature, time in preparation method
The selection of skill condition can treatment in accordance with local conditions and substantial effect is had no to result.Embodiment each component proportioning is all weight percentage.
Embodiment 1:25%hnpc-a8008 MTI-446 suspending agent
When the present invention is processed into suspending agent, the weight percentage of each component is: hnpc-a8008 12.5%；MTI-446
12.5%；Emulsifying agent: by-140 5%, NPE 8%；Solvent: Ketohexamethylene 5%, methanol 8%；Wetting agent: fourth
Base sodium naphthalene sulfonate: 3%；Dispersant: alkyl benzene calcium sulfonate: 3%；Antifreezing agent: propylene glycol 1%；Thickening agent: xanthan gum 0.1%；Disappear
Infusion organosilicon: 0.1%；Deionized water adds to 100%.The concrete production stage of this suspending agent is: first will except effective ingredient it
Outer said components are mixed, and through high speed shear mix homogeneously, are subsequently adding effective ingredient hnpc-a8008 and MTI-446,
Grind 2～3 hours in ball crusher, make diameter of particle all below 5 μm, that is, make the aqueous suspension formulations of the present composition.
Embodiment 2:12.1%hnpc-a8008 MTI-446 aqueous emulsion
When the present invention is processed into aqueous emulsion, the weight percentage of each component is: hnpc-a8008 0.1%；MTI-446
12%；Emulsifying agent agriculture breast 500#6%, NPE 5%；Solvent: Ketohexamethylene 6%, methanol 7%；；Stabilizer: lemon
Lemon acid sodium 1%；Antifreezing agent: propylene glycol 1%；Thickening agent: xanthan gum 0.1%；Deionized water adds to 100%.The tool of this aqueous emulsion
Body production stage is: is added together hnpc-a8008 with MTI-446, solvent and emulsifying agent first, makes dissolving uniformly oily
Phase；Then the others auxiliary agent such as portions of de-ionized water, stabilizer is mixed uniformly aqueous phase；Then in a kettle.
While high-speed stirred, oil phase being added aqueous phase, slowly adding water until reaching phase inversion point, open cutter and carry out high speed shear, and
Add remaining deionized water, shearing about half an hour, form the aqueous emulsion of oil-in-water type, you can make the water of the present composition
Emulsion preparations.
Embodiment 3:12.1%hnpc-a8008 dinotefuran micron-emulsion
When the present invention is processed into microemulsion, the weight percentage of each component is: hnpc-a8008 12%；MTI-446
0.1%；Solvent: Ketohexamethylene 4%, methanol 7%；Emulsifying agent: alkyl benzene calcium sulfonate 5%, benzyl dimethyl phenol polyoxyethyl ether
7%；Antifreezing agent: propylene glycol 1%；Stabilizer: sodium citrate 1%；Deionized water adds to 100%.The concrete production of this microemulsion
Step is: first hnpc-a8008 is completely dissolved with MTI-446 solvent, adds other auxiliary agents such as emulsifying agent, antifreezing agent,
It is uniformly mixed in stirring mixing kettle, you can make the microemulsion formulation of the present composition.
Embodiment 4:70%hnpc-a8008 MTI-446 wettable powder
When the present invention is wettable powder, the weight percentage of each component is: hnpc-a8008 35%；MTI-446
35%；Dispersant: lignosulfonates 5%；Wetting agent: pull open powder bx 5%；Filler: Pulvis Talci 6%；Kaolin adds to
100%.The concrete production stage of this wettable powder is: by effective ingredient hnpc-a8008 and MTI-446 and dispersant, profit
Humectant and filler mixing, again through comminution by gas stream, mix homogeneously after mechanical activation comminution, you can make the wettable powder of the present composition
Agent formulation.Effective ingredient hnpc-a8008 is mixed with MTI-446 and dispersant, wetting agent and filler, warp again after mechanical activation comminution
Comminution by gas stream, mix homogeneously, you can make the wettable powder formulation of the present composition.
Embodiment 5:25%hnpc-a8008 MTI-446 water dispersible granules
When the present invention is water dispersible granules, the weight percentage of each component is: hnpc-a8008 20%；MTI-446
5%；Dispersant: calcium salt of dodecylbenzene sulfonate 10%；Wetting agent: wetting and penetrating agent f 8%；Disintegrating agent: sodium chloride 2%；Fill out
Material Pulvis Talci 5%；Kaolin adds to 100%.The concrete production stage of this water dispersible granules is: by above-mentioned formula by effective ingredient
Hnpc-a8008 is mixed homogeneously with MTI-446 and dispersant, wetting agent, disintegrating agent and filler, uses micro jet powder
Broken, through mediating, be subsequently adding in fluidized-bed granulation dryer carry out pelletize, drying, after screening through sample analysis, you can make this
The water-dispersible grain agent formulation of inventive composition.
Described solvent can be deionized water, methanol, ethanol, butanol, propylene glycol, glycerol, Polyethylene Glycol, hexamethylene
The mixing of one or more of ketone, ketopyrrolidine, ethyl acetate.
Described emulsifying agent can be agriculture breast 500#(alkyl benzene calcium sulfonate), agriculture breast 400#(benzyl dimethyl phenol polyoxyethanyl
Ether), Nongru-700#(alkylphenol-formaldehyde resin polyoxyethyl ether), agriculture breast 1600#(phenethyl phenol polyoxyethanyl polypropylene-base ether),
Styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, epoxy ethane-epoxy propane are embedding
Section copolymer, op series (NPE), by series (castor oil polyoxyethylene ether), Span series (sorbitol anhydride
Monostearate), TWEEN Series (anhydrous sorbitol fat acid ester APEO) or aeo series (fatty alcohol-polyoxyethylene ether) in
One or several mixing.
Described wetting agent can be sodium lauryl sulphate, dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate, oil sulphur
The mixing of one or more of sour sodium, wetting and penetrating agent f, pull open powder bx, tea seed cake powder, spaonin powder, spaonin powder etc..
Described disintegrating agent can be sodium bicarbonate, magnesium chloride, aluminum chloride, sodium chloride, carbamide, ammonium sulfate, bentonite etc.
One or more of mixing.
Described dispersant can be lignosulfonates, polycarboxylate, alkylphenol polyoxyethylene sulfate, alkylbenzene
One or more of sulfonic acid calcium salt, fatty acid ester sulfate, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether etc. mixed
Close.
Described thickening agent can be polyvinyl alcohol, polyvinyl acetate, xanthan gum, gelatin, Radix Acaciae senegalis, polyethylene
The mixing of one or more of ketopyrrolidine, aluminium-magnesium silicate, phenolic resin, hydroxymethyl cellulose, sodium alginate etc..
Described stabilizer can be with xylitol, Mannitol, tetramethylolmethane, triphenyl phosphite, sodium citrate etc.
Plant or several mixing.
Described defoamer can be selected from organosilicon, silicone compound, c10-20Saturated fat acids compound, c8-10
The mixing of one or more of fatty alcohol.
Described antifreezing agent can be the mixing of one or more in glycerol, propylene glycol, diethylene glycol, Polyethylene Glycol etc..
Described filler can be precipitated calcium carbonate, potter's clay, Kaolin, kieselguhr, bentonite, white carbon, Pulvis Talci, stone
The mixing of one or more of Ying Sha etc..
The Pesticidal combination that the present invention provides, is generally used using the method for spraying it is also possible to adopt agricultural as needed
Other of upper application use technology.For example conventional Pesticide use method: nebulization, bait method, seed treatment, seed pelleting
Method, soil treatment method, semar technique etc..
The Pesticidal combination that the present invention provides, in application it should be noted that using in insect egg hatching peak period to low instar larvae phase
Medicine, now insect resistance is weaker has easily given play to best drug effect.
The invention has the advantages that
1. the composition pesticide that the present invention provides, shows obvious potentiation, compositionss in certain ratio range
Prevention effect be significantly improved than single dose, reduce using dosage, dispenser recruitment and the cost of pesticide simultaneously, decrease
Impact to environment and pesticide residues.There is to insect obvious potentiation killing action, and can overcome and delay pest resistance to insecticide
Generation；
2. overcome the narrower limitation of single chemical control spectrum, expand preventing and treating spectrum, a dispenser can prevent and treat simultaneously
The various pests occurring.
3. it is the excellent substitute kind of high-toxic pesticide.When every mu of effective ingredient consumption is 1～8g, the present composition can
Effectively preventing and treating vegetable, Oryza sativa L., the Lepidoptera of Cotton Gossypii, fruit tree and flowers and other crops and homoptera pest.
Specific embodiment
Essence for a better understanding of the present invention, with reference to embodiment, the invention will be further described, but never
It is limited to following embodiments.
Embodiment 6:hnpc-a8008 and MTI-446 compound to diamondback moth joint toxicity measuring.
For trying target: the indoor for many generations raising Individual Size diamondback moth third-instar larvae consistent with physiological statuss.
Reagent agent: 95%hnpc-a8008 active compound and 95% MTI-446 active compound.
Test method: survey standard method ny/t1154.14-2008 with reference to raw, using leaching leaf dish method.Reagent agent is made into
Certain density mother solution, then it is stand-by to be diluted to 6 concentration with clear water, if clear water is comparison.To be rolled up with the card punch of diameter 18mm
Heart dish breaks into leaf dish, after leaf dish is impregnated 10 seconds in for reagent liquid, puts into the culture dish (diameter 90mm) being lined with moisturizing filter paper
In, 5 leaf dish put into by every ware, and after waiting nature to dry, then diamondback moth 3 instar larvae having selected 4h hungry is in culture dish, every ware
It is not less than 10,4 repetitions, it is disposed, covers ware lid, be placed in observation indoor cultivation, routine observation, check note after 72hr
Record death condition, calculate mortality rate (%), and according to probit analysis obtain virulence regression equation, correlation coefficient (r) and
Lethal middle trial (lc50).Co-toxicity coefficient method (ctc) method being proposed using sun＆johnson (1960) evaluates synergy.Typically
Ground, co-toxicity coefficient is more than 120 expression potentiations, is antagonism less than 80, is summation action between 80～120.Altogether
Malicious coefficient formulas are as follows:
The toxicity index of mixture theoretical toxicity index (the tti)=medicament a × shared percent in mixture of a medicament (%)
The toxicity index of+medicament b × shared the percent in mixture of b medicament (%)
Hnpc-a8008, MTI-446 and the two 1: 1,40: 1,80: 1,120: 1,1: 40,1: 80 and 1: 120 ratio mixture
1 be the results are shown in Table to the toxicity test of diamondback moth.Result shows, hnpc-a8008 and MTI-446 carry out mixture with above-mentioned 7 ratios
Obvious potentiation is shown as to diamondback moth, its lc50Value is respectively 1.65,0.99,1.01,1.12,13.20,15.74 and
20.91mg/l, co-toxicity coefficient is respectively 178.42,159.26,154.29,138.59,167.95,168.76 and 136.18.
Table 1, the hnpc-a8008 and MTI-446 and different ratio toxicity test (72h) to wild cabbage diamondback moth
Embodiment 7:hnpc-a8008 compounds the joint toxicity measuring to planthopper with MTI-446.
For trying target: the indoor for many generations raising Individual Size brown plant-hopper (nilaparvata consistent with physiological statuss
Lugens) tritonymph.
Reagent agent: 95%hnpc-a8008 active compound and 95% MTI-446 active compound.
Test method: survey standard method ny/t1154.11-2008 with reference to raw, using rice-stem dipping method, choose two leaf one core
15 plants of rice seedling, in for reagent liquid, dipping, after 30 seconds, takes out nature and dries, encase root moisturizing with wet absorbent cotton, outsourcing is fresh-keeping
Film, is placed in teat glass (φ 200 × 30mm), every 4 repetitions of concentration.Then with the rice of brush pen access ether light anesthesia
Plant hopper 3 age nymph, often pipe 15 ± 2, the mouth of pipe is tightened with white gauze.It is disposed, be placed in observation indoor.Routine observation, in
Inspection record death condition after 72hr, calculates mortality rate (%), and obtains virulence regression equation, phase according to probit analysis
Close coefficient (r) and lethal middle trial (lc50).Co-toxicity coefficient method (ctc) the method evaluation being proposed using sun＆johnson (1960)
Synergy.Usually, co-toxicity coefficient is more than 120 expression potentiations, is antagonism less than 80, between 80～120
For summation action.Co-toxicity coefficient computing formula is as follows:
The toxicity index of mixture theoretical toxicity index (the tti)=medicament a × shared percent in mixture of a medicament (%)
The toxicity index of+medicament b × shared the percent in mixture of b medicament (%)
Hnpc-a8008, MTI-446 and the two 1: 1,40: 1,80: 1,120: 1,1: 40,1: 80 and 1: 120 ratio mixture
2 be the results are shown in Table to the toxicity test of planthopper.From table, hnpc-a8008 and MTI-446 carry out mixture with above-mentioned 7 ratios
Obvious potentiation is all shown as to planthopper, its lc50Value is respectively 2.05,7.88,9.46,10.64,1.22,1.30 and
1.48mg/l, co-toxicity coefficient is respectively 176.27,162.26,144.45,131.49,172.47,160.16 and 140.19.
Table 2, the hnpc-a8008 and MTI-446 and different ratio toxicity test (72h) to planthopper
Embodiment 8: co-toxicity coefficient method (ctc) screening: hnpc-a8008 and MTI-446 are compounding to combine poison to orange caterpillar
Power measures.
With reference to the method in ny/t1154.13-2008 standard, using leaf disc spray.Choose the consistent Citrus leaf of growth
Piece, makes leaf dish with the card punch of diameter 18mm, places a wet sponge block, put filter paper thereon in culture dish, foliation on filter paper
Dish, every three leaf dish of ware, it is inoculated on leaf dish with the consistent orange caterpillar of brush pen picking Individual Size, 10～15, every leaf dish.
The atomisation pressure of potter spray tower is adjusted 1.47 × 105The steady statue of pa, will be first clear with acetone for the fog-spray nozzle cleaned
Wash 2 times, cleaned with distilled water 2 times.Culture dish is placed in potter spraying tower chassis sprayed, spray amount 1ml, medicinal liquid sinks
Take out after fall 1min, then seal ware mouth with preservative film, and prick the ventilation of some apertures with syringe needle on film, often process 4 repetitions,
And blank is made in the process setting without medicament (containing solvent for use and emulsifying agent).It is disposed to be transferred to and raise under rearing conditions
Support.Inspection record death condition after 48h, calculates mortality rate (%), and obtains virulence regression equation according to probit analysis
Formula, correlation coefficient (r) and lethal middle trial (lc50).Co-toxicity coefficient method (ctc) method being proposed using sun＆johnson (1960)
Evaluate synergy.Usually, co-toxicity coefficient is more than 120 expression potentiations, is antagonism less than 80, between 80～120
Between be summation action.Co-toxicity coefficient computing formula is as follows:
The toxicity index of mixture theoretical toxicity index (the tti)=medicament a × shared percent in mixture of a medicament (%)
The toxicity index of+medicament b × shared the percent in mixture of b medicament (%)
Hnpc-a8008, MTI-446 and the two 1: 1,1: 40,1: 80,1: 120,40: 1,80: 1 and 120: 1 ratio mixture
3 be the results are shown in Table to the toxicity test of orange caterpillar.From table, hnpc-a8008 and MTI-446 are mixed with above-mentioned 7 ratios
Pairing striped rice borer all shows as obvious potentiation, its lc50Value is respectively 0.62,0.71,0.82,0.91,0.58,0.66 and
0.75mg/l, co-toxicity coefficient is respectively 172.75,160.06,138.80,125.14,174.63,153.25 and 134.80.
Table 3, the hnpc-a8008 and MTI-446 and different ratio toxicity test (72h) to orange caterpillar
Embodiment 9: co-toxicity coefficient method (ctc) screening: hnpc-a8008 and MTI-446 are compounding to combine poison to Prodenia litura
Power measures.
Survey standard method ny/t1154.14-2008 with reference to raw, using leaching leaf dish method.To be rolled up with the card punch of diameter 18mm
Heart dish breaks into leaf dish, after leaf dish is impregnated 10 seconds in for reagent liquid, puts into the culture dish (diameter 90mm) being lined with moisturizing filter paper
In, 5 leaf dish put into by every ware, and after waiting nature to dry, then Prodenia litura 3 instar larvae having selected 4h hungry is in culture dish, often
Ware is not less than 10,4 repetitions, is disposed, covers ware lid, is placed in observation indoor cultivation.Inspection record death feelings after 72h
Condition, calculate mortality rate (%), and according to probit analysis obtain virulence regression equation, correlation coefficient (r) and lethal in taste
Examination (lc50).Co-toxicity coefficient method (ctc) method being proposed using sun＆johnson (1960) evaluates synergy.Usually, malicious altogether
Coefficient is more than 120 expression potentiations, is antagonism less than 80, is summation action between 80～120.Co-toxicity coefficient meter
Calculate formula as follows:
The toxicity index of mixture theoretical toxicity index (the tti)=medicament a × shared percent in mixture of a medicament (%)
The toxicity index of+medicament b × shared the percent in mixture of b medicament (%)
Hnpc-a8008, MTI-446 and the two 1: 1,1: 40,1: 80,1: 120,40: 1,80: 1 and 120: 1 ratio mixture
4 be the results are shown in Table to the toxicity test of orange caterpillar.From table, hnpc-a8008 and MTI-446 are mixed with above-mentioned 7 ratios
Pairing striped rice borer all shows as obvious potentiation, its lc50Value is respectively 2.04,1.22,1.42,1.53,14.79,18.86
And 20.67mg/l, co-toxicity coefficient respectively 181.93,165.26,140.36,129.76,157.65,142.73 and 137.42.
Table 4, the hnpc-a8008 and MTI-446 and different ratio toxicity test (72h) to Prodenia litura
Embodiment 10:hnpc-a8008 and the field control effectiveness test to wild cabbage diamondback moth for the dinotefuran mixed compositionss.
Reagent agent: (1) 25%hnpc-a8008 MTI-446 suspending agent (hnpc-a8008 5%: MTI-446 20%)；
2) 15%hnpc-a8008 MTI-446 aqueous emulsion (hnpc-a8008 5%: MTI-446 20%).
Comparison medicament: (1) 10%hnpc-a8008 suspending agent (c)；(2) 20% MTI-446 wettable powder (d).
Spraying time: be watered even spraying in the wild cabbage diamondback moth low instar larvae phase.
Result of the test: be shown in Table 5.As can be seen from the test results, 1 day after dispenser, the composition pesticide of the present invention is to Caulis et Folium Brassicae capitatae
The prevention effect of diamondback moth is all more than 70% hence it is evident that being better than single dose；3 days after dispenser, 7 days and 14 days, the pesticide group of the present invention
Compound all more than 80%, is also considerably better than single dose, the Pesticidal combination of the present invention is described to the prevention effect of wild cabbage diamondback moth
It is superior to single dose in terms of quick-acting and lasting effect, and cost substantially reduces.
Table 5, each field control effectiveness test result processing chemical control wild cabbage diamondback moth
Embodiment 11:hnpc-a8008 and the field control effectiveness test to planthopper for the dinotefuran mixed compositionss.
Reagent agent: (1) 70%hnpc-a8008 MTI-446 water dispersible granules (hnpc-a8008 35%: MTI-446
35%)；2) 40%hnpc-a8008 MTI-446 wettable powder (hnpc-a8008 15%: MTI-446 25%).
Comparison medicament: (1) 10%hnpc-a8008 suspending agent (g)；(2) 20% MTI-446 wettable powders.
This embodiment is used for preventing and treating rice hoppers, investigates insect population, after medicine, 1d, 3d, 7d, 14d adjust respectively before dispenser
Look into residual borer population alive, during investigation, every cell is carried out by parallel jump method, investigates at 20 points, 2 clumps every, shake or pat rice clump, system
Between meter rice clump, the plant hopper quantity of floating on water, calculates prevention effect.
Spraying time: be watered even spraying in the rice hoppers low instar nymphs phase.
Result of the test: be shown in Table 6.As can be seen from the test results, 1 day after dispenser, the composition pesticide of the present invention flies to rice
The prevention effect of louse is all more than 70% hence it is evident that being better than single dose；3 days after dispenser, 7 days and 14 days, the composition pesticide of the present invention
To the prevention effect of planthopper all more than 82%, also it is considerably better than single dose, the Pesticidal combination that the present invention is described is in quick-acting
It is superior to single dose with lasting effect aspect, and cost substantially reduces.
Table 6, each field control effectiveness test result processing chemical control planthopper
Embodiment 12:hnpc-a8008 and the field control effectiveness test to orange caterpillar for the dinotefuran mixed compositionss
Reagent agent: (1) 25%hnpc-a8008 MTI-446 water dispersible granules (hnpc-a8008 20%: MTI-446
5%) (i)；2) 15%hnpc-a8008 dinotefuran micron-emulsion (hnpc-a8008 12%: MTI-446 3%) (j).
Comparison medicament: (1) 10%hnpc-a8008 suspending agent (k)；(2) 20% MTI-446 wettable powder (l).
Spraying time: be watered even spraying in orange caterpillar occurrence in peak period.
Result of the test: be shown in Table 7.As can be seen from the test results, 1 day after dispenser, the composition pesticide of the present invention is to Citrus
The prevention effect of aphid all more than 70% hence it is evident that be better than 3 days after single medicine, 7 days and 14 days, the composition pesticide of the present invention is to sweet
The prevention effect of blue diamondback moth, all more than 80%, is also considerably better than single dose, and the Pesticidal combination that the present invention is described is in quick-acting
It is superior to single dose with lasting effect aspect, and cost substantially reduces.
Table 7, each field control effectiveness test result processing chemical control orange caterpillar
Embodiment 13:hnpc-a8008 and the field control effectiveness test to Chinese rose Prodenia litura for the dinotefuran mixed compositionss
Reagent agent: (1) 25%hnpc-a8008 MTI-446 water dispersible granules (hnpc-a8008 20%: MTI-446
5%)；2) 15%hnpc-a8008 dinotefuran micron-emulsion (hnpc-a8008 12%: MTI-446 3%).
Comparison medicament: (1) 10%hnpc-a8008 suspending agent；(2) 20% MTI-446 wettable powders.
Spraying time: be watered even spraying in Chinese rose Prodenia litura occurrence in peak period.
Result of the test: be shown in Table 8.As can be seen from the test results, 1 day after dispenser, the composition pesticide of the present invention is to Citrus
The prevention effect of aphid all more than 70% hence it is evident that be better than 3 days after single medicine, 7 days and 14 days, the composition pesticide of the present invention is to the moon
Season Prodenia litura prevention effect all more than 80%, be also considerably better than single dose, the Pesticidal combination that the present invention is described is quick-acting
Property and lasting effect aspect are superior to single dose, and cost substantially reduces.
Table 8, each field control effectiveness test result processing chemical control Chinese rose Prodenia litura
Claims (3)
1. a kind of preventing and treating Lepidoptera and homoptera pest Pesticidal combination are it is characterised in that insecticidal active ingredient is chemical name is
(e) -5- (3- chlorallyl) amino -1- (2,6- dichlor-4-trifluoromethyl) phenyl -4- trifluoromethyl sulfinyl pyrazole -3-
The hnpc-a8008 of nitrile and MTI-446, the chemical structural formula of hnpc-a8008 is:
The weight of hnpc-a8008 and MTI-446 is than for 1:120～120:1；Hnpc-a8008 accounts for group with the weight sum of MTI-446
The 1%～70% of compound gross weight, the dosage form of compositionss includes suspending agent or aqueous emulsion, microemulsion, wettable powder, moisture dissipate
Granule.
2. according to claim 1 preventing and treating Lepidoptera and homoptera pest Pesticidal combination it is characterised in that:
During the dosage form suspending agent of compositionss, the weight percentage of each component is hnpc-a8008 0.1～20%；MTI-446 0.1
～20%；Emulsifying agent 5～15%；Solvent 5～20%；Wetting agent 3～10%；Dispersant 3～10%；Antifreezing agent 1～5%；Increase
Thick dose 0.1～2%；Defoamer 0.1～1%；Deionized water adds to 100%；
During the dosage form aqueous emulsion of compositionss, the weight percentage of each component is: hnpc-a8008 0.1～25%；MTI-446
0.1～25%；Emulsifying agent 5～25%；Solvent 5～15%；Stabilizer 1～10%；Antifreezing agent 1～5%；Thickening agent 0.1～
2%；Deionized water adds to 100%；
During the dosage form microemulsion of compositionss, the weight percentage of each component is: hnpc-a8008 0.1～20%；MTI-446
0.1～20%；Solvent 10～30%；Emulsifying agent 5～30%；Antifreezing agent 1～5%；Stabilizer 1～10%；Deionized water adds to
100%；
During the dosage form wettable powder of compositionss, the weight percentage of each component is: hnpc-a800810～60%；MTI-446
10～60%；Dispersant 5～10%；Wetting agent 5～10%；Filler adds to 100%；
During the dosage form water dispersible granules of compositionss, the weight percentage of each component is: hnpc-a8008 1～69%；MTI-446
1～69%；Dispersant 5～15%；Wetting agent 5～10%；Disintegrating agent 1～8%；Filler adds to 100%；
Described wetting agent is sodium lauryl sulphate, dodecylbenzene sodium sulfonate, sodium butylnaphthalenesulfonate, petroleum sodium sulfonate, draws
Open the mixing of one or more of powder bx, tea seed cake powder, spaonin powder, spaonin powder；
Described dispersant is lignosulfonates, polycarboxylate, alkylphenol polyoxyethylene sulfate, alkyl benzene calcium sulfonate
One of salt, fatty acid ester sulfate, alkylphenol polyoxyethylene, sodium metnylene bis-naphthalene sulfonate, fatty alcohol-polyoxyethylene ether
Or several mixing；
Described antifreezing agent is glycerol, propylene glycol, diethylene glycol, the mixing of one or more in Polyethylene Glycol；
Described thickening agent is polyvinyl alcohol, polyvinyl acetate, xanthan gum, gelatin, Radix Acaciae senegalis, polyvinylpyrrolidine
The mixing of one or more of ketone, aluminium-magnesium silicate, phenolic resin, hydroxymethyl cellulose, sodium alginate；
Described defoamer is silicone oil, silicone compound, c10-20Saturated fat acids compound, c8-10One kind of fatty alcohol or
Several mixing；
Described solvent is deionized water, methanol, ethanol, butanol, propylene glycol, glycerol, Polyethylene Glycol, Ketohexamethylene, pyrrolidine
The mixing of one or more of ketone, ethyl acetate；
Described emulsifying agent is alkyl benzene calcium sulfonate, benzyl dimethyl phenol polyoxyethyl ether, alkylphenol-formaldehyde resin polyoxyethanyl
Ether, phenethyl phenol polyoxyethanyl polypropylene-base ether, styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salt,
Triethanolamine salt, ethylene oxide-propylene oxide block copolymer, NPE, castor oil polyoxyethylene ether, Pyrusussuriensiss
One of alcohol acid anhydride monostearate, anhydrous sorbitol fat acid ester APEO, fatty alcohol-polyoxyethylene ether or several mixing
Close；
Described stabilizer is one or more of xylitol, Mannitol, tetramethylolmethane, triphenyl phosphite, sodium citrate
Mixing；
Described filler be precipitated calcium carbonate, potter's clay, Kaolin, kieselguhr, bentonite, white carbon, Pulvis Talci, in quartz sand
The mixing of one or more；
Described disintegrating agent be one of sodium bicarbonate, magnesium chloride, aluminum chloride, sodium chloride, carbamide, ammonium sulfate, bentonite or
Several mixing.
3. the purposes of preventing and treating Lepidoptera according to claim 1 and 2 and homoptera pest Pesticidal combination, its feature exists
In: the Pesticidal combination containing hnpc-a8008 and MTI-446 is used for preventing and treating the Lepidoptera of vegetable, Oryza sativa L., fruit tree and flower crop
And homoptera pest.
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