CN102771495B - Pesticide synergic insect-killing composition containing guadipyr - Google Patents
Pesticide synergic insect-killing composition containing guadipyr Download PDFInfo
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Abstract
The invention discloses a pesticide synergic insect-killing composition containing guadipyr. The active components of the composition comprise an active component A guadipyr and an active component B that is any one or two of flonicamid, flubendiamide, cyantraniliprole and tolfenpyrad. The weight ratio of the active component A to the active component B is 50:1 to 1:50. The insect-killing and acari-killing composition can achieve higher insect-killing effect than each active component used separately, namely after the formulation, the obvious synergic effect is generated; the composition can effectively control piercing-sucking mouthpart and lepidoptera pests and insects, so that the pesticide usage amount and times can be reduced, furthermore the resistance of the pests or insects to the composition can be delayed or conquered.
Description
Technical field
The invention belongs to technical field of pesticide, relate in particular to a kind of pesticide synergistic Pesticidal combination containing penta pyrrole worm guanidine with excellent insecticidal action.
Background technology
Penta pyrrole worm guanidine (Guadipyr) is the method that adopts MOLECULE DESIGN to splice mutually with active substructure by the Qin Zhao of China Agricultural University sea teach problem group, the ingenious establishment of active structure of anabasine (take Imidacloprid as representative) and contracting amine ureas (take indoxacarb as representative) insecticide, in same a part, has been obtained to the new and effective desinsection series compound that has anabasine and sodium-ion channel inhibitor characteristics concurrently.
Penta pyrrole worm guanidine chemical name: 1-nitro-3-[(6-chloropyridine-3-yl) methyl]-4-penta methene amido guanidine, its chemical structural formula:
Penta pyrrole worm guanidine has unique mechanism of action, and sucking pest is had to excellent preventive effect, than the anabasine insecticide preventive effects such as Imidacloprid significantly and the lasting period longer, be the preferred agents of control sucking pest.
In recent years, the harm of the lepidoptera pests such as the sucking pest such as aphid, plant hopper, aleyrodid and diamond-back moth, beet armyworm is rampant, and more and more serious, has become the High risk population in paddy rice, vegetables, fruit tree and Greenhouse structure.This class pest is due to characteristics such as its breeding are fast, and breeding amount is large, and generation overlap is obvious, very fast to the resistance generation of medicament, thereby has strengthened difficulty of prevention and cure.The pesticide compositional of the different mechanisms of action is delay and administer one of effective way of resistance; Simultaneously, different mechanism pesticide compositionals, except effectively delaying and administering pest resistance, can also effectively reduce dosage and drug cost, environmental contamination reduction.
For carrying out the comprehensive regulation of insect pest, adopt at present best mode to be the composite reagent of the different mechanisms of action, and in the integrated control to sucking mouth parts and lepidoptera pest, ideal with penta pyrrole worm guanidine and amide-type pesticide compositional.
Application patent for penta pyrrole worm guanidine mainly contains at present:
Chinese patent: 201110306796.X, denomination of invention: a kind of Pesticidal combination and preparation thereof and application, this patent relates to described Pesticidal combination and is comprised of penta pyrrole worm guanidine and Imidacloprid.Invent acceptable auxiliary material on described Pesticidal combination and pesticidal preparations by this and form, the mass percent that described Pesticidal combination accounts for described insecticide is 1-85%.This insecticidal effect of inventing described Pesticidal combination and preparation thereof significantly improves, and has the notable synergistic effect, can delay the generation of pest resistance to insecticide, can be widely used in agriculture field.
Chinese patent: 201110306778.1, denomination of invention: a kind of Pesticidal combination and preparation thereof and application, this is invented described Pesticidal combination and is comprised of penta pyrrole worm guanidine and Rynaxypyr.Invent acceptable auxiliary material on described Pesticidal combination and pesticidal preparations by this and form, the mass percent that described Pesticidal combination accounts for described insecticide is 1-85%.This insecticidal effect of inventing described Pesticidal combination and preparation thereof significantly improves, and has the notable synergistic effect, can prevent and treat lepidoptera pest and sucking pest simultaneously, delays the generation of pest resistance to insecticide, can be widely used in agriculture field.
Summary of the invention
The object of the present invention is to provide a kind of agricultural chemical composition for disinsection, the active ingredient of said composition is any one or both in active components A penta pyrrole worm guanidine and active component B, and wherein active component B comprises following composition: flonicamid, fipronil bisamide, cyanogen insect amide, Tolfenpyrad.
Said composition has obvious synergistic effect to preventing insect, not only can reduce the usage amount of active ingredient, reduces use cost, can also delay the generation of pest resistance, for the improvement of resistant insect.In addition, said composition provides a kind of composition that is more suitable for agricultural use, is particularly useful for the insects such as aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, diamond-back moth, beet armyworm.
The technical scheme taked to achieve the object of the present invention is as follows:
Pesticide and miticide farm chemical composition of the present invention comprises active components A: penta pyrrole worm guanidine, and active component B, active component B is: any one in flonicamid, fipronil bisamide, cyanogen insect amide or Tolfenpyrad.
Wherein the part by weight of active components A and active component B is 50:1-1:50.
Another kind of improvement project of the present invention is: the weight ratio of active components A and active component B is preferably 20:1-1:20.
The present invention can be processed into according to actual agricultural use suitable various formulations, comprising: but wetting powder, water dispersible granules, suspending agent dispersed oil suspending agent, suspension emulsion, ultra low volume liquids or dry suspending agent.
In these preparations, except active component, all contain surfactant, and can also contain organic solvent or the thinners such as cosolvent, carrier (filler) or water according to different dosage form.Add in case of necessity other functional aids such as antifreeze, thickener, stabilizing agent, defoamer, disintegrant.
Described auxiliary agent is one or more in dispersant NNO, lauryl sodium sulfate, Dispersant MF, sodium lignin sulfonate, polyvinyl alcohol, agriculture breast 600#, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, alkylphenol polyoxyethylene phosphate, naphthalene sulfonic acid formaldehyde condensation polymer, ammonium sulfate or agriculture breast 500#.
Described solvent is one or more in ethylene glycol, dimethyl formamide or ethyl acetate.
Described carrier is one or more in white carbon, kaolin, precipitated calcium carbonate, potter's clay or water.
The various formulations of the present invention, be applicable to spray, dress seed, soak root, soak seed, smear, fill with and execute various occupation modes.
For preventing and treating the various pests on the agricultural various crop, described insect mainly comprises lepidoptera pest and sucking mouth parts class pest.
The present composition is applicable to the various pests evil mite in agricultural, and described insect mainly comprises lepidoptera pest and sucking mouth parts class pest, is particularly useful for aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, scale insect, two spotted spider mite etc.
The present invention has following advantage:
1, can effectively prevent and treat the various pests evil mite on agricultural, especially to aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, scale insect, two spotted spider mite texts excellence.
2, active component described in composition has obvious synergistic effect after composite, thereby has reduced usage amount and the use cost of active component, has improved the safety of medicament to environment simultaneously.
3, obviously delay the resistance generation of insect evil mite, and antagonism insect evil mite is effectively administered.
The accompanying drawing explanation
Accompanying drawing is the basic flow sheet of preparation composition pesticide suspending agent of the present invention.
Embodiment
Below by embodiment, the invention will be further described.It should be understood that the described preparation method of the embodiment of the present invention is only used for illustrating the present invention, rather than limitation of the present invention, the simple modifications to preparation method of the present invention under design prerequisite of the present invention all belongs to the scope of protection of present invention.
In example of formulations, we introduce the detailed ratio of composition, and in biologically active embodiment, we introduce the outstanding biologically active of composition in detail.The preparation of paper disinsection prophylaxis poison composition.
This product is comprised of active ingredient, auxiliary agent, solvent three parts, the components such as former medicine, auxiliary agent, solvent are mixed in mixing kettle, then will in mixture suction sand mill, carry out sand milling, after active ingredient is sanded to particle diameter and is 5 about μ m, the suction blender is mixed again.The various auxiliary agents that add in this patent etc. can keep preparation stablizing under high temperature, low temperature, contribute to storage, transportation, guarantee drug effect.
The various auxiliary agents that the present invention adds, solvent etc. are the market sale product, and pesticide producing is commonly used assistant agent.
Embodiment 1 51% penta pyrrole worm guanidine flonicamid suspending agents (50:1)
360 gram deionized waters in the suction agitator tank, by in 50 gram sodium lignin sulfonates, 20 gram lauryl sodium sulfate, 50 gram ethylene glycol, suction agitator tank, then limit is stirred 500 gram penta pyrrole worm guanidines, 10 gram flonicamids, 10 gram white carbons, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 51% penta pyrrole worm guanidine flonicamid suspending agents.
Embodiment 2 40% penta pyrrole worm guanidine fipronil bisamide suspension agents (39:1)
465 gram deionized waters in the suction agitator tank, by in 40 gram Dispersant MFs, 40 gram sodium lignin sulfonates, 35 gram ethylene glycol, suction agitator tank, then limit is stirred 390 gram penta pyrrole worm guanidines, 10 gram fipronil bisamides, 20 gram kaolin, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 40% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 3 26% penta pyrrole worm guanidine flonicamid suspending agents (25:1)
570 gram deionized waters in the suction agitator tank, by in 40 gram dispersant NNO, 40 gram Dispersant MFs, 50 gram lauryl sodium sulfate, 20 gram ethylene glycol, suction agitator tank, then limit is stirred 250 gram penta pyrrole worm guanidines, 10 gram flonicamids, 20 gram kaolin, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 26% penta pyrrole worm guanidine flonicamid suspending agents.
Embodiment 4 21% penta pyrrole worm guanidine cyanogen insect amide suspending agents (20:1)
590 gram deionized waters in the suction agitator tank, by in 60 gram dispersant NNO, 40 gram alkylphenol polyoxyethylene phosphates, 40 gram lauryl sodium sulfate, 30 gram ethylene glycol, suction agitator tank, then limit is stirred 200 gram penta pyrrole worm guanidines, 10 gram cyanogen insect amides, 30 gram white carbons, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 21% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Embodiment 5 16% penta pyrrole worm guanidine fipronil bisamide suspension agents (15:1)
650 gram deionized waters in the suction agitator tank, by in 40 gram naphthalene sulfonic acid formaldehyde condensation polymers, 40 gram Dispersant MFs, 20 gram fatty alcohol-polyoxyethylene ether, 50 gram ethylene glycol, suction agitator tank, then limit is stirred 150 gram penta pyrrole worm guanidines, 10 gram fipronil bisamides, 35 gram potter's clay, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 16% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 6 36% penta pyrrole worm guanidine fipronil bisamide suspension agents (5:1)
469 gram deionized waters in the suction agitator tank, by in 60 gram alkylphenol polyoxyethylene phosphates, 40 gram Dispersant MFs, 20 gram polyoxyethylene nonylphenol ether and 10 gram calories pine preservative, 40 gram ethylene glycol, suction agitator tank, then limit is stirred 300 gram penta pyrrole worm guanidines, 60 gram fipronil bisamides, 1 gram xanthans, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 30% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 7 30% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:1)
490 gram deionized waters in the suction agitator tank, by in the dense newborn 600# of 60 gram, 40 gram Dispersant MFs, 20 gram fatty alcohol-polyoxyethylene ether, 40 gram ethylene glycol, suction agitator tank, then limit is stirred 150 gram penta pyrrole worm guanidines, 150 gram cyanogen insect amides, 50 gram polyvinyl alcohol, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 55% penta pyrrole worm guanidine carbosulfan suspending agents.
Embodiment 8 36% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:5)
450 gram deionized waters in the suction agitator tank, by in 50 gram sodium lignin sulfonates, 40 gram Dispersant MFs, 20 gram fatty alcohol-polyoxyethylene ether and 40 gram ammonium sulfate, suction agitator tank, then limit is stirred 60 gram penta pyrrole worm guanidines, 300 gram cyanogen insect amides, 40 gram polyvinyl alcohol, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 36% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Embodiment 9 21% penta pyrrole worm guanazole insect amide suspending agents (1:20)
610 gram deionized waters in the suction agitator tank, by in the dense newborn 600# of 50 gram, 40 gram Dispersant MFs, 20 gram fatty alcohol-polyoxyethylene ether, 40 gram ethylene glycol, suction agitator tank, then limit is stirred 10 gram penta pyrrole worm guanidines, 200 gram Tolfenpyrads, 30 gram white carbons, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 21% penta pyrrole worm guanazole insect amide suspending agents.
Embodiment 10 31% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:30)
520 gram deionized waters in the suction agitator tank, by in the dense newborn 600# of 40 gram, 40 gram Dispersant MFs, 20 gram fatty alcohol-polyoxyethylene ether, 40 gram ethylene glycol, suction agitator tank, then limit is stirred 10 gram penta pyrrole worm guanidines, 300 gram cyanogen insect amides, 30 gram potter's clay, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 31% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Example 11 41% penta pyrrole worm guanidine fipronil bisamide suspension agents (1:40)
439 gram deionized waters in the suction agitator tank, by in 40 gram alkylphenol polyoxyethylene phosphates, 40 gram Dispersant MFs, 20 gram polyoxyethylene nonylphenol ether and 10 gram calories pine preservative, 40 gram ethylene glycol, suction agitator tank, then limit is stirred 10 gram penta pyrrole worm guanidines, 400 gram fipronil bisamides, 1 gram xanthans, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 41% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 12 51% penta pyrrole worm guanazole insect amide suspending agents (1:50)
330 gram deionized waters in the suction agitator tank, by in 50 gram polyoxyethylene nonylphenol ether, 40 gram dispersant NNO, 10 gram lauryl sodium sulfate, 30 gram ethylene glycol, suction agitator tank, then limit is stirred 10 gram penta pyrrole worm guanidines, 500 gram Tolfenpyrads, 30 gram white carbons, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, obtains 51% penta pyrrole worm guanazole insect amide suspending agents.
Embodiment 13 85% penta pyrrole worm guanidine flonicamid wetting powders (16:1)
By flonicamid 800 grams, penta pyrrole worm guanidine 50 grams, Dispersant MF 40 grams, dispersant NNO 40 grams, lauryl sodium sulfate 50 grams, white carbon 20 grams, stir, and adopts comminution by gas stream processing, gets final product to obtain 85% penta pyrrole worm guanidine flonicamid wetting powders.
Embodiment 14 60% penta pyrrole worm guanazole insect amide water dispersible granules (30:30)
By Tolfenpyrad 300 grams, penta pyrrole worm guanidine 300 grams, white carbon 50 grams, Dispersant MF 50 grams, lauryl sodium sulfate 40 grams, precipitated calcium carbonate 100 grams, ammonium sulfate 160 grams, mix laggard air-flow crushing, in mixer, spray into and mediate approximately 180 grams of agent deionized water, adjust extrusion equipment, carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, gets final product to obtain 60% penta pyrrole worm guanazole insect amide water dispersible granules.
Embodiment 15 52% penta pyrrole worm guanazole insect amide water dispersible granules (1:12)
By Tolfenpyrad 480 grams, penta pyrrole worm guanidine 40 grams, white carbon 100 grams, Dispersant MF 50 grams, lauryl sodium sulfate 50 grams, potter's clay 100 grams, ammonium sulfate 180 grams, mix laggard air-flow crushing, in mixer, spray into and mediate approximately 180 grams of agent deionized water, adjust extrusion equipment, carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, gets final product to obtain 52% penta pyrrole worm guanazole insect amide water dispersible granules.
Embodiment 16 55% penta pyrrole worm guanidine flonicamid water dispersible granules (10:1)
By flonicamid 50 grams, penta pyrrole worm guanidine 500 grams, white carbon 100 grams, dispersant NNO 50 grams, lauryl sodium sulfate 40 grams, precipitated calcium carbonate 100 grams, ammonium sulfate 160 grams, mix laggard air-flow crushing, in mixer, spray into and mediate approximately 180 grams of agent deionized water, adjust extrusion equipment, carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, gets final product to obtain 55% penta pyrrole worm guanidine flonicamid water dispersible granules.
But embodiment 17 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents (4:1)
The 600 grams sour methyl esters that deoils in the suction agitator tank, by in 20 gram polyoxyethylene nonylphenol ether, 60 gram castor oil polyoxyethylene ethers and 50 gram agricultures breast 500#, suction agitator tank, then limit is stirred 200 gram penta pyrrole worm guanidines, 50 gram cyanogen insect amides, 20 gram organobentonites, is dropped into and shear in tank in order, shears and makes mixing of materials even in 30 minutes.Open cycle water, by the material ball milling, with a certain amount of flow, temperature is controlled below 40 degree, and fineness is crossed 325 mesh sieves, but obtains 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents.
Embodiment 18 2% penta pyrrole worm guanidine fipronil bisamide ultra low volume liquids (1:1)
Take the finished product ultra low volume liquids as weight 1000 grams calculating, penta pyrrole worm guanidine 10 grams, fipronil bisamide 10 grams, dimethyl formamide 50 grams, ethyl acetate 50 grams, alkylphenol polyoxyethylene phosphate 50 grams, neopelex 55 grams, the two wires oil solvent complements to 1000 grams, stirs 30 minutes, to fully transparent, detect after qualified and be 2% penta pyrrole worm guanidine fipronil bisamide ultra low volume liquids.
Embodiment 19 1.1% penta pyrrole worm guanidine flonicamid ultra low volume liquids (0.1:1)
Take the finished product ultra low volume liquids as weight 1000 grams calculating, penta pyrrole worm guanidine 1 gram, flonicamid 10 grams, dimethyl formamide 80 grams, ethyl acetate 40 grams, polyoxyethylene nonylphenol ether phosphate 60 grams, neopelex 40 grams, the two wires oil solvent complements to 1000 grams, stirs 30 minutes, to fully transparent, detect after qualified and be 1.1% penta pyrrole worm guanidine flonicamid ultra low volume liquids.
Embodiment 20 50% penta pyrrole worm guanazole insect amide dry suspending agents (10:40)
By penta pyrrole worm guanidine 100 grams, Tolfenpyrad 400 grams, alkylaryl polyoxyethylene polyoxypropylene ether 50 grams, polyoxyethylene nonylphenol ether phosphate 40 grams, Dispersant MF 60 grams, add in mixed solution, 600 grams of suction deionized water again, stir, then carry out coarse crushing with high-speed shearing machine, enter again the fine grinding of two-stage sand mill, add white carbon 150 grams after levigate, enter pressure spray drying tower drying or granulation after kaolin 200 grams, make powdery or microgranular solid, detect after qualified and be 50% penta pyrrole worm guanazole insect amide dry suspending agents.During use, enter after water identically with the suspending agent effect, but bin stability is better than again suspending agent.
The field experiment drug effect
The embodiment of the present invention is the method that adopts indoor virulence and field trial to combine.First by Toxicity Determination, whether synergy or addition after clear and definite two kinds of medicaments are composite by a certain percentage.The co-toxicity coefficient of built agent (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80<CTC<120 show as summation action.
Toxicity Determination embodiment
1, penta pyrrole worm guanidine proportioning co-toxicity tests different from fipronil bisamide
1.1 reagent agent
The 96% penta former medicines of pyrrole worm guanidine, the former medicine of 95% fipronil bisamide, penta pyrrole worm guanidine and fipronil bisamide different proportion mixture preparation
1.2 for examination worm source
Cabbage aphid
1.3 single dose assay method
Adopt dip method that two former medicines are all used to a small amount of acetone solution, then become the solution of 5 concentration of equal difference with 0.1% tween water capacity easily dilutable, be diluted in beaker with standby, and with clear water in contrast.Three generations's cabbage aphid adult of the same size is flooded to 5s in the liquid that soaks the worm cage, suck unnecessary liquid and be placed in the culture dish of 9cm afterwards, be placed with fresh cabbage leaves in ware and cover.Every concentration is processed 10, repeats 4 times, establishes blank.In 27 degree illumination boxs, keep checking lethality after 24h, it is dead touching the polypide nonresponder by pulling needle.Lethality is proofreaied and correct for examination with Abbott, then, according to concentration logarithm-lethality probability value analytical method, obtains virulence regression equation and lethal.
1.4 the joint toxicity measuring method of different proportionings
The toxicity test result of foundation single dose, by active ingredient mass ratio penta pyrrole worm guanidine: the proportioning that fipronil bisamide is respectively 16:1,8:1,1:1,1:8,1:16 is mixed.Adopt above-mentioned 1.3 methods to carry out independent mensuration, calculate LC50, and press the abundant method of Sun Yun and calculate co-toxicity coefficient (CTC).The co-toxicity coefficient computing formula is as follows:
In formula: ATI---mixture actual measurement toxicity index;
S---the LC of standard insecticide
50, unit is every liter (mg/L) of milligram;
The LC of M---mixture
50, unit is every liter (mg/L) of milligram.
TTI＝TI
A×P
A+TI
B×P
B……………………………………(2)
Calculate the theoretical toxicity index of mixture according to following formula
In formula: TTI---the theoretical toxicity index of mixture;
TI
a---A medicament toxicity index;
P
athe percentage composition of-A medicament in mixture, unit is percentage (%);
TI
b---B medicament toxicity index;
P
b---the percentage composition of B medicament in mixture, unit is percentage (%).
Calculate the co-toxicity coefficient of mixture according to following formula
In formula: CTC---co-toxicity coefficient;
ATI---mixture actual measurement toxicity index;
The theoretical toxicity index of TTI---mixture.
The co-toxicity coefficient of built agent (CTC) >=120 shows as synergistic effect; CTC≤80 show as antagonism; 80<CTC<120 show as summation action.
2.1 toxicity test result
As can be seen from the above table, after two compositions of penta pyrrole worm guanidine and fipronil bisamide are composite again under each proportioning its co-toxicity coefficient all be greater than 120, illustrating that these two kinds of compositions are composite has an obvious synergistic effect, penta pyrrole worm guanidine and fipronil bisamide are mixed and have very strong reasonability and feasibility, all are worth further carrying out the land for growing field crops popularization.
2, penta pyrrole worm guanidine and cyanogen insect amide are to cucumber trialeurodes vaporariorum Toxicity Determination
2.1 test method
Adopt spray-on process.Choose with writing brush examination worm that physiological status is consistent and be no less than 30 and put into culture dish, then culture dish is placed in to the Potter spray tower tries to get to the heart of a matter and quantitatively spray, spray value is 1ml, takes out the examination worm after liquid sedimentation 1min and is raised.Every processing repeats for many 4 times, and establishes blank.Process 96 and as a child checked examination worm death condition.
2.2 experimental result
Composite its co-toxicity coefficient of each ratio of penta pyrrole worm guanidine and cyanogen insect amide is all higher than 120 as can be seen from the above table, illustrate that these two kinds of compositions have raising clearly to the preventive effect of cucumber trialeurodes vaporariorum after composite, as can be seen here, these two kinds of compositions are composite has obvious synergistic effect, has application prospect preferably.
3, the Toxicity Determination of penta pyrrole worm guanidine and Tolfenpyrad antagonism diamond-back moth
3.1 test method
Adopt and first to soak after leaf the method that connects worm, take out, naturally dry after the of the same size fresh cabbage leaves that does not contact any medicament is flooded to 5s in the liquid configured, put into insect box, then connect for examination diamondback moth larvae in 3 age, under 25 degree conditions, raise, every processing repeats for 3 times, and every the repetition, with 30 of examination worms, arranges blank simultaneously, check dead borer population after 72h, calculate lethality and corrected mortality, obtain regression equation, calculate LC50 and co-toxicity coefficient.
3.2 result of the test
As seen from the above table, in the different proportion of penta pyrrole worm guanidine and Tolfenpyrad, its co-toxicity coefficient all is greater than 120, has showed obvious synergistic effect, wherein take penta pyrrole worm guanidine: Tolfenpyrad as 1:10 the time its synergistic effect the most obvious.
4, penta pyrrole worm guanidine and the flonicamid indoor virulence test to apple yellow aphid
4.1 test method
Adopt the leaf butterfly spray-on process, choose the consistent cabbage leaves of growth, with the card punch of diameter 18mm, make leaf butterfly, 3 leaf butterflies of every ware, 30 apple yellow aphids of every leaf butterfly, every processing repeats 4 times, and establishes blank.Check dead borer population in 72h, calculate lethality and corrected mortality, ask virulence regression equation and co-toxicity coefficient.
4.2 result of the test
By above-mentioned result of the test, can be found out, penta pyrrole worm guanidine and the flonicamid rear preventive effect to apple yellow aphid that is mixed all increases than single dose, the co-toxicity coefficient of its each mixed ratio, all higher than 120, illustrates that the composite rear control to the sucking mouth parts apple yellow aphid of these two kinds of compositions has very strong synergistic effect.
Field experiment embodiment
Carry out field medicine effect test by embodiment 1-13 gained complex preparation and each component single dose.Select calmly without rainy day gas, to be tested, in all stage of investigation without rainfall, and before experiment, after test 1,3,7 day investigation insect pest situation, calculate drug effect according to following formula:
Insect population is counted insect population number after * treatment region medicine before preventive effect (%)=1-(blank medicine)/(before and after the blank medicine before mouthful number * treatment region medicine insect population number)
Result of the test is as follows:
1, penta pyrrole worm guanidine flonicamid composition is to the cotten aphid field trial
The control efficiency of table 1 51% penta pyrrole worm guanidine flonicamid suspending agents to cotten aphid
As can be seen from the above table, 51% penta pyrrole worm guanidine flonicamid suspending agents to the preventive effect of cotten aphid each single dose be significantly improved, also shown suitable with the high-load single dose and better preventive effect when consumption is lower, has illustrated that the composite rear control to cotten aphid of these two kinds of compositions of penta pyrrole worm guanidine and flonicamid has obvious synergistic effect.
2, the field trial of penta pyrrole worm guanidine fipronil bisamide composition to the wild cabbage diamond-back moth
The control efficiency of table 2 16% penta pyrrole worm guanidine fipronil bisamide suspension agents to the wild cabbage diamond-back moth
As can be seen from the above table, 16% penta pyrrole worm guanidine fipronil bisamide suspension agents when to the preventive effect of wild cabbage diamond-back moth, each single dose is used all obviously preventive effect want high, illustrate that the composite rear control to the wild cabbage diamond-back moth of these two kinds of compositions of penta pyrrole worm guanidine and fipronil bisamide has obvious synergistic effect.
3, penta pyrrole worm guanidine and the cyanogen insect amide compound field trial to rice fulgorid
But the control efficiency of table 3 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents to rice fulgorid
As seen from the above table, control efficiency to rice fulgorid after penta pyrrole worm guanidine and cyanogen insect amide are composite obviously improves, under same preventive effect, its usage amount reduces greatly, therefore penta pyrrole worm guanidine and cyanogen insect amide two compositions are composite has obvious synergistic effect to the rice fulgorid control afterwards, is conducive to reduce the medicament usage amount and improves preventive effect.
4, the field trial of penta pyrrole worm guanazole insect amide composition to diamond-back moth
Table 4 50% penta pyrrole worm guanazole insect amide dry suspending agents are to the diamond-back moth field experiment
As can be seen from the above table, penta pyrrole worm guanidine and multiple killing teichomycin compound obviously increase the preventive effect of diamond-back moth, and consumption also all has minimizing than two single doses, illustrate that the composite control efficiency to diamond-back moth of these two kinds of compositions has obvious synergistic effect, can also delay and administer the resistance problem of diamond-back moth simultaneously.
Comprehensive above several field experiment conclusions can be found out, after any composition in penta pyrrole worm guanidine of the present invention and flonicamid, fipronil bisamide, cyanogen insect amide, Tolfenpyrad is composite, controlling object is had to obvious synergistic effect, greatly reduce the usage amount of active ingredient under equal control efficiency, thereby reduced the harm of environment and the resistance that has delayed insect.
Comprehensive above result of the test can be found out, in penta pyrrole worm guanidine and flonicamid proposed by the invention, cyanogen insect amide, Tolfenpyrad, fipronil bisamide any carry out composite after, its control efficiency to agricultural insect pest obviously improves, not only reduced the usage amount of active ingredient, also increased the control spectrum, various pests in agricultural is had to desirable control efficiency, be worth promoting in the practical application of land for growing field crops.
Claims (6)
1. the pesticide synergistic Pesticidal combination containing penta pyrrole worm guanidine, wherein active component is comprised of active components A penta pyrrole worm guanidine and active component B cyanogen insect amide; The weight ratio of described active components A and active component B is 40:1-1:40.
2. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 1, it is characterized in that: the weight ratio of active components A and active component B is preferably 20:1-1:20.
3. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 1 is characterized in that: also contain the auxiliary agent that uses in pesticidal preparations, solvent, carrier auxiliary element to make the formulation of various applicable agricultural uses;
Described auxiliary agent is one or more in dispersant NNO, lauryl sodium sulfate, Dispersant MF, sodium lignin sulfonate, polyvinyl alcohol, agriculture breast 600#, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, alkylphenol polyoxyethylene phosphate, naphthalene sulfonic acid formaldehyde condensation polymer, ammonium sulfate or agriculture breast 500#;
Described solvent is one or more in ethylene glycol, dimethyl formamide or ethyl acetate;
Described carrier is one or more in white carbon, kaolin, precipitated calcium carbonate, potter's clay or water.
4. according to the described pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine of claim 1 or 3, it is characterized in that: described formulation has wetting powder, water dispersible granules, suspending agent, ultra low volume liquids.
5. according to the described pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine of claim 1 or 3, it is characterized in that: be applicable to spray, dress seed, soak root, soak seed, smear, fill with and execute.
6. the arbitrary described pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine of claim 1-3, it is characterized in that: for preventing and treating the various pests on the agricultural various crop, described insect mainly comprises lepidoptera pest and sucking mouth parts class pest.
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