CN102771495A - Pesticide synergic insect-killing composition containing guadipyr - Google Patents
Pesticide synergic insect-killing composition containing guadipyr Download PDFInfo
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- CN102771495A CN102771495A CN2012102560403A CN201210256040A CN102771495A CN 102771495 A CN102771495 A CN 102771495A CN 2012102560403 A CN2012102560403 A CN 2012102560403A CN 201210256040 A CN201210256040 A CN 201210256040A CN 102771495 A CN102771495 A CN 102771495A
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Abstract
The invention discloses a pesticide synergic insect-killing composition containing guadipyr. The active components of the composition comprise an active component A guadipyr and an active component B that is any one or two of flonicamid, flubendiamide, cyantraniliprole and tolfenpyrad. The weight ratio of the active component A to the active component B is 50:1 to 1:50. The insect-killing and acari-killing composition can achieve higher insect-killing effect than each active component used separately, namely after the formulation, the obvious synergic effect is generated; the composition can effectively control piercing-sucking mouthpart and lepidoptera pests and insects, so that the pesticide usage amount and times can be reduced, furthermore the resistance of the pests or insects to the composition can be delayed or conquered.
Description
Technical field
The invention belongs to technical field of pesticide, relate in particular to a kind of pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine with excellent insecticidal action.
Background technology
Penta pyrrole worm guanidine (Guadipyr) is the method that adopts MOLECULE DESIGN and active substructure to splice mutually by the Qin Zhaohai of China Agricultural University professor seminar; With active structure ingenious set up with in a part of anabasine (is representative with the Imidacloprid), obtained to have concurrently the new and effective desinsection series compound of anabasine and sodium-ion channel inhibitor characteristics with amine ureas (is representative with the indenes worm prestige) insecticide that contracts.
Penta pyrrole worm guanidine chemical name: 1-nitro-3-[(6-chloropyridine-3-yl) methyl]-4-penta methene amido guanidine, its chemical structural formula:
Penta pyrrole worm guanidine has unique mechanism of action, and sucking pest is had excellent preventive effect, than anabasine insecticide preventive effects such as Imidacloprid significantly and the lasting period longer, be the preferred agents of control sucking pest.
In recent years, the harm of lepidoptera pests such as sucking pest such as aphid, plant hopper, aleyrodid and diamond-back moth, beet armyworm is rampant, and more and more serious, has become the keypoint control object in paddy rice, vegetables, fruit tree and the protection ground pattern of farming.This class pest is owing to characteristics such as its breeding are fast, and breeding amount is big, and generation overlap is obvious, and is very fast to the resistance generation of medicament, thereby strengthened difficulty of prevention and cure.The pesticide compositional of different effects mechanism is to delay and administer one of effective way of resistance; Simultaneously, different mechanism pesticide compositionals can also effectively reduce dosage and drug cost except effectively delaying and administering the pest resistance, reduce environmental pollution.
For carrying out the comprehensive regulation of insect pest, the mode that employing is best at present is the composite reagent of different effects mechanism, and in the integrated control to sucking mouth parts and lepidoptera pest, ideal with penta pyrrole worm guanidine and amide-type pesticide compositional.
Application patent to penta pyrrole worm guanidine mainly contains at present:
Chinese patent: 201110306796.X, denomination of invention: a kind of Pesticidal combination and preparation thereof and application, this patent relate to said Pesticidal combination and are made up of penta pyrrole worm guanidine and Imidacloprid.Invent on said Pesticidal combination and the pesticidal preparations acceptable auxiliary material by this and form, the mass percent that said Pesticidal combination accounts for said insecticide is 1-85%.This insecticidal effect of inventing said Pesticidal combination and preparation thereof significantly improves, and has the notable synergistic effect, can delay the generation of pest resistance to insecticide, can be widely used in agriculture field.
Chinese patent: 201110306778.1, denomination of invention: a kind of Pesticidal combination and preparation thereof and application, this is invented said Pesticidal combination and is made up of penta pyrrole worm guanidine and Rynaxypyr.Invent on said Pesticidal combination and the pesticidal preparations acceptable auxiliary material by this and form, the mass percent that said Pesticidal combination accounts for said insecticide is 1-85%.This insecticidal effect of inventing said Pesticidal combination and preparation thereof significantly improves, and has the notable synergistic effect, can prevent and treat lepidoptera pest and sucking pest simultaneously, delays the generation of pest resistance to insecticide, can be widely used in agriculture field.
Summary of the invention
The object of the present invention is to provide a kind of agricultural chemical composition for disinsection; The active ingredient of said composition is any one or both among active components A penta pyrrole worm guanidine and the active component B, and wherein active component B comprises following composition: flonicamid, fipronil bisamide, cyanogen insect amide, azoles insect amide.
Said composition has obvious synergistic effect to preventing insect, not only can reduce the usage amount of active ingredient, reduces use cost, can also delay the generation of pest resistance, is used for the improvement of resistant insect.In addition, said composition provides a kind of composition that agricultural is used that is more suitable for, and is particularly useful for insects such as aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, diamond-back moth, beet armyworm.
Following for reaching the technical scheme that the object of the invention takes:
Pesticide and miticide farm chemical composition of the present invention comprises active components A: penta pyrrole worm guanidine and active component B, active component B is: any one in flonicamid, fipronil bisamide, cyanogen insect amide or the azoles insect amide.
Wherein the part by weight of active components A and active component B is 50:1-1:50.
Another kind of improvement project of the present invention is: the weight ratio of active components A and active component B is preferably 20:1-1:20.
The present invention can use according to the agricultural of reality and be processed into suitable various formulations, comprising: but wetting powder, water dispersible granules, suspending agent dispersed oil suspending agent, suspension emulsion, ultra low volume liquids or dry suspending agent.
In these preparations, except that active component, all contain surfactant, and can also contain organic solvent or thinners such as cosolvent, carrier (filler) or water according to different dosage form.Add other functional aids such as antifreeze, thickener, stabilizing agent, antifoaming agent, disintegrant in case of necessity.
Said auxiliary agent is one or more among dispersant NNO, lauryl sodium sulfate, Dispersant MF, sodium lignin sulfonate, polyvinyl alcohol, agricultural newborn 600#, AEO, NPE, APES phosphate, naphthalene sulfonic acid formaldehyde condensation polymer, ammonium sulfate or the agricultural newborn 500#.
Said solvent is one or more in ethylene glycol, dimethyl formamide or the ethyl acetate.
Said carrier is one or more in white carbon, kaolin, precipitated calcium carbonate, potter's clay or the water.
The various formulations of the present invention are applicable to spraying, dress seed, soak root, soak seed, smear, irritate and execute various occupation modes.
Be used for preventing and treating the various pests on the agricultural various crop, described insect mainly comprises lepidoptera pest and sucking mouth parts class pest.
The present composition is applicable to the various pests evil mite in the agricultural, and described insect mainly comprises lepidoptera pest and sucking mouth parts class pest, is particularly useful for aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, scale insect, two spotted spider mite etc.
The present invention has following advantage:
1, the various pests that can effectively prevent and treat on the agricultural does harm to mite, and is especially excellent to effects such as aphid, plant hopper, aleyrodid, wood louse, thrips, leafhopper, beetle, scale insect, two spotted spider mite.
2, active component described in the composition has obvious synergistic effect after composite, thereby has reduced the usage amount and the use cost of active component, has improved medicament simultaneously to safety of environment property.
3, obviously delay the resistance generation of insect evil mite, and antagonism insect evil mite is administered effectively.
Description of drawings
Accompanying drawing is the basic flow sheet of preparation composition pesticide suspending agent of the present invention.
Embodiment
Through embodiment the present invention is described further below.It should be understood that the said preparation method of the embodiment of the invention is only used for explaining the present invention, rather than limitation of the present invention, under design prerequisite of the present invention, preparation method's of the present invention simple modifications is all belonged to the present invention and require the scope protected.
In FORMULATION EXAMPLE, we introduce the detailed ratio of composition, and in biologically active embodiment, we introduce the outstanding biologically active of composition in detail.At first introduce disinsection prophylaxis poison preparation of compositions.
These article are made up of active ingredient, auxiliary agent, solvent three parts; Components such as former medicine, auxiliary agent, solvent are mixed in mixing kettle; Then with carrying out sand milling in the mixture suction sand mill, treat active ingredient be sanded to particle diameter be about 5 μ m after, the suction blender mixes once more.The various auxiliary agents that add in this patent etc. can keep preparation stablizing under high temperature, low temperature, help storage, transportation, guarantee drug effect.
The various auxiliary agents that the present invention added, solvent etc. are the market sale product, and pesticide producing is used assistant agent always.
Embodiment 1 51% penta pyrrole worm guanidine flonicamid suspending agents (50:1)
360 gram deionized waters in the suction agitator tank; In 50 gram sodium lignin sulfonates, 20 gram lauryl sodium sulfate, 50 gram ethylene glycol, suction agitator tank; The limit is stirred 500 grams, penta pyrrole worm guanidine, 10 gram flonicamids, 10 gram white carbons, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 51% penta pyrrole worm guanidine flonicamid suspending agents.
Embodiment 2 40% penta pyrrole worm guanidine fipronil bisamide suspension agents (39:1)
465 gram deionized waters in the suction agitator tank; In 40 gram Dispersant MFs, 40 gram sodium lignin sulfonates, 35 gram ethylene glycol, suction agitator tank; The limit is stirred 390 grams, penta pyrrole worm guanidine, 10 gram fipronil bisamides, 20 gram kaolin, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 40% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 3 26% penta pyrrole worm guanidine flonicamid suspending agents (25:1)
570 gram deionized waters in the suction agitator tank; In 40 gram dispersant NNO, 40 gram Dispersant MFs, 50 gram lauryl sodium sulfate, 20 gram ethylene glycol, suction agitator tank; The limit is stirred 250 grams, penta pyrrole worm guanidine, 10 gram flonicamids, 20 gram kaolin, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 26% penta pyrrole worm guanidine flonicamid suspending agents.
Embodiment 4 21% penta pyrrole worm guanidine cyanogen insect amide suspending agents (20:1)
590 gram deionized waters in the suction agitator tank; In 60 gram dispersant NNO, 40 gram APES phosphates, 40 gram lauryl sodium sulfate, 30 gram ethylene glycol, suction agitator tank; The limit is stirred 200 grams, penta pyrrole worm guanidine, 10 gram cyanogen insect amides, 30 gram white carbons, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 21% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Embodiment 5 16% penta pyrrole worm guanidine fipronil bisamide suspension agents (15:1)
650 gram deionized waters in the suction agitator tank; In 40 gram naphthalene sulfonic acid formaldehyde condensation polymers, 40 gram Dispersant MFs, 20 gram AEOs, 50 gram ethylene glycol, suction agitator tank; The limit is stirred 150 grams, penta pyrrole worm guanidine, 10 gram fipronil bisamides, 35 gram potter's clay, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 16% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 6 36% penta pyrrole worm guanidine fipronil bisamide suspension agents (5:1)
469 gram deionized waters in the suction agitator tank; In 60 gram APES phosphates, 40 gram Dispersant MFs, 20 gram NPEs and 10 gram calories pine preservative, 40 gram ethylene glycol, suction agitator tank; The limit is stirred 300 grams, penta pyrrole worm guanidine, 60 gram fipronil bisamides, 1 gram xanthans, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 30% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 7 30% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:1)
490 gram deionized waters in the suction agitator tank; In the dense newborn 600# of 60 grams, 40 gram Dispersant MFs, 20 gram AEOs, 40 gram ethylene glycol, suction agitator tank; The limit is stirred 150 grams, penta pyrrole worm guanidine, 150 gram cyanogen insect amides, 50 gram polyvinyl alcohol, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 55% penta pyrrole worm guanidine carbosulfan suspending agents.
Embodiment 8 36% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:5)
450 gram deionized waters in the suction agitator tank; In 50 gram sodium lignin sulfonates, 40 gram Dispersant MFs, 20 gram AEOs and 40 gram ammonium sulfate, suction agitator tank; The limit is stirred 60 grams, penta pyrrole worm guanidine, 300 gram cyanogen insect amides, 40 gram polyvinyl alcohol, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 36% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Embodiment 9 21% penta pyrrole worm guanazole insect amide suspending agents (1:20)
610 gram deionized waters in the suction agitator tank; In the dense newborn 600# of 50 grams, 40 gram Dispersant MFs, 20 gram AEOs, 40 gram ethylene glycol, suction agitator tank; The limit is stirred 10 grams, penta pyrrole worm guanidine, 200 gram azoles insect amides, 30 gram white carbons, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 21% penta pyrrole worm guanazole insect amide suspending agents.
Embodiment 10 31% penta pyrrole worm guanidine cyanogen insect amide suspending agents (1:30)
520 gram deionized waters in the suction agitator tank; In the dense newborn 600# of 40 grams, 40 gram Dispersant MFs, 20 gram AEOs, 40 gram ethylene glycol, suction agitator tank; The limit is stirred 10 grams, penta pyrrole worm guanidine, 300 gram cyanogen insect amides, 30 gram potter's clay, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 31% penta pyrrole worm guanidine cyanogen insect amide suspending agents.
Instance 11 41% penta pyrrole worm guanidine fipronil bisamide suspension agents (1:40)
439 gram deionized waters in the suction agitator tank; In 40 gram APES phosphates, 40 gram Dispersant MFs, 20 gram NPEs and 10 gram calories pine preservative, 40 gram ethylene glycol, suction agitator tank; The limit is stirred 10 grams, penta pyrrole worm guanidine, 400 gram fipronil bisamides, 1 gram xanthans, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 41% penta pyrrole worm guanidine fipronil bisamide suspension agents.
Embodiment 12 51% penta pyrrole worm guanazole insect amide suspending agents (1:50)
330 gram deionized waters in the suction agitator tank; In 50 gram NPEs, 40 gram dispersant NNO, 10 gram lauryl sodium sulfate, 30 gram ethylene glycol, suction agitator tank; The limit is stirred 10 grams, penta pyrrole worm guanidine, 500 gram azoles insect amides, 30 gram white carbons, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, promptly gets 51% penta pyrrole worm guanazole insect amide suspending agents.
Embodiment 13 85% penta pyrrole worm guanidine flonicamid wetting powders (16:1)
With flonicamid 800 gram, penta pyrrole worm guanidine, 50 grams, Dispersant MF 40 grams, dispersant NNO 40 grams, lauryl sodium sulfate 50 grams, white carbon 20 grams stir, and adopt comminution by gas stream processing, get final product 85% penta pyrrole worm guanidine flonicamid wetting powders.
Embodiment 14 60% penta pyrrole worm guanazole insect amide water dispersible granules (30:30)
With azoles insect amide 300 grams, penta pyrrole worm guanidine, 300 grams, white carbon 50 grams, Dispersant MF 50 grams, lauryl sodium sulfate 40 grams; Precipitated calcium carbonate 100 grams, ammonium sulfate 160 grams mix laggard comminution by gas stream; In mixer, spray into and mediate about 180 grams of agent deionized water, adjustment extrusion equipment; Carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, get final product 60% penta pyrrole worm guanazole insect amide water dispersible granules.
Embodiment 15 52% penta pyrrole worm guanazole insect amide water dispersible granules (1:12)
With azoles insect amide 480 grams, penta pyrrole worm guanidine, 40 grams, white carbon 100 grams, Dispersant MF 50 grams, lauryl sodium sulfate 50 grams; Potter's clay 100 grams, ammonium sulfate 180 grams mix laggard comminution by gas stream; In mixer, spray into and mediate about 180 grams of agent deionized water, adjustment extrusion equipment; Carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, get final product 52% penta pyrrole worm guanazole insect amide water dispersible granules.
Embodiment 16 55% penta pyrrole worm guanidine flonicamid water dispersible granules (10:1)
With flonicamid 50 grams, penta pyrrole worm guanidine, 500 grams, white carbon 100 grams, dispersant NNO 50 grams, lauryl sodium sulfate 40 grams; Precipitated calcium carbonate 100 grams, ammonium sulfate 160 grams mix laggard comminution by gas stream; In mixer, spray into and mediate about 180 grams of agent deionized water, adjustment extrusion equipment; Carry out extruder grain, it is qualified under 50～80 ℃ of conditions, to dry to moisture, get final product 55% penta pyrrole worm guanidine flonicamid water dispersible granules.
But embodiment 17 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents (4:1)
600 restrain the sour methyl esters that deoils in the suction agitator tank; In 20 gram NPEs, 60 gram castor oil polyoxyethylene ethers and the agricultural newborn 500# of 50 grams, suction agitator tank; The limit is stirred 200 grams, penta pyrrole worm guanidine, 50 gram cyanogen insect amides, 20 gram organobentonites, is dropped in order and shear jar then, shears to make mixing of materials even in 30 minutes.Open cycle water, with a certain amount of flow, below temperature control 40 degree, fineness is crossed 325 mesh sieves with the material ball milling, but promptly gets 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents.
Embodiment 18 2% penta pyrrole worm guanidine fipronil bisamide ultra low volume liquids (1:1)
With the finished product ultra low volume liquids is that weight 1000 grams calculate, penta pyrrole worm guanidine, 10 grams, fipronil bisamide 10 grams; Dimethyl formamide 50 grams, ethyl acetate 50 grams, APES phosphate 50 grams; Neopelex 55 grams, the two wires oil solvent complements to 1000 grams, stirs 30 minutes; To transparent fully, detect and be 2% penta pyrrole worm guanidine fipronil bisamide ultra low volume liquids after qualified.
Embodiment 19 1.1% penta pyrrole worm guanidine flonicamid ultra low volume liquids (0.1:1)
With the finished product ultra low volume liquids is that weight 1000 grams calculate, penta pyrrole worm guanidine, 1 gram, flonicamid 10 grams; Dimethyl formamide 80 grams, ethyl acetate 40 grams, NPE phosphate 60 grams; Neopelex 40 grams, the two wires oil solvent complements to 1000 grams, stirs 30 minutes; To transparent fully, detect and be 1.1% penta pyrrole worm guanidine flonicamid ultra low volume liquids after qualified.
Embodiment 20 50% penta pyrrole worm guanazole insect amide dry suspending agents (10:40)
With penta pyrrole worm guanidine, 100 grams, azoles insect amide 400 grams, alkylaryl polyoxyethylene polyoxypropylene ether 50 grams, NPE phosphate 40 grams, Dispersant MF 60 grams; Add in the mixed solution, suction deionized water 600 grams stir again; Carry out coarse crushing with high-speed shearing machine then; Get into the fine grinding of two-stage sand mill again, levigate back adds white carbon 150 grams, and kaolin 200 gram backs get into pressure spray dryer tower drying or granulation; Process powdery or microgranular solid, detect and be 50% penta pyrrole worm guanazole insect amide dry suspending agents after qualified.Identical after the entry during use with the suspending agent effect, but bin stability is superior to suspending agent again.
The field experiment drug effect
The embodiment of the invention is the method that adopts indoor virulence and field trial to combine.Earlier through Toxicity Determination, whether synergy or addition after clear and definite two kinds of medicaments are composite by a certain percentage.Composite dose co-toxicity coefficient (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination embodiment
1, the different proportioning co-toxicity tests of penta pyrrole worm guanidine with fipronil bisamide
1.1 supply the reagent agent
The 96% penta former medicines of pyrrole worm guanidine, the former medicine of 95% fipronil bisamide, penta pyrrole worm guanidine and fipronil bisamide different proportion mixture preparation
1.2 supply examination worm source
Cabbage aphid
1.3 single agent assay method
Adopt dip method with two former medicines all with the small amount of acetone dissolving, become the solution of 5 concentration of equal difference again with 0.1% tween water capacity easily dilutable, be diluted in the beaker with subsequent use, and with clear water as contrast.Three generations's cabbage aphid adult of the same size is flooded 5s in the soup that soaks the worm cage, inhale and go to be placed in the culture dish of 9cm after the unnecessary soup, be placed with fresh cabbage leaves in the ware and cover.Every concentration is handled 10, repeats 4 times, establishes blank.In 27 degree illumination boxs, keep checking lethality behind the 24h, use group pin to touch the polypide nonresponder and be death.Lethality supplies examination to proofread and correct with Abbott, again according to concentration logarithm-lethality probability value analytical method, obtains virulence regression equation and causes death.
1.4 the joint toxicity measuring method of different proportionings
The toxicity test result of the single agent of foundation, by active ingredient mass ratio penta pyrrole worm guanidine: the proportioning that fipronil bisamide is respectively 16:1,8:1,1:1,1:8,1:16 is mixed.Adopt above-mentioned 1.3 methods to carry out independent mensuration, calculate LC50, and press the abundant method of Sun Yun and calculate co-toxicity coefficient (CTC).The co-toxicity coefficient computing formula is following:
In the formula: ATI---mixture actual measurement toxicity index;
S---the LC of standard insecticide
50, unit is every liter (mg/L) of milligram;
The LC of M---mixture
50, unit is every liter (mg/L) of milligram.
TTI＝TI
A×P
A+TI
B×P
B……………………………………(2)
Calculate the theoretical toxicity index of mixture according to formula
In the formula: TTI---the theoretical toxicity index of mixture;
TI
A---A medicament toxicity index;
P
AThe percentage composition of-A medicament in mixture, unit are percentage (%);
TI
B---B medicament toxicity index;
P
B---the percentage composition of B medicament in mixture, unit are percentage (%).
Calculate the co-toxicity coefficient of mixture according to formula
In the formula: CTC---co-toxicity coefficient;
ATI---mixture actual measurement toxicity index;
The theoretical toxicity index of TTI---mixture.
Composite dose co-toxicity coefficient (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
2.1 toxicity test result
Can find out by last table; After two compositions of penta pyrrole worm guanidine and fipronil bisamide are composite again under each proportioning its co-toxicity coefficient all greater than 120; Explaining that these two kinds of compositions are composite has an obvious synergistic effect; Penta pyrrole worm guanidine and fipronil bisamide are mixed and have very strong reasonability and feasibility, all are worth further carrying out the land for growing field crops and promote.
2, penta pyrrole worm guanidine and cyanogen insect amide are to cucumber trialeurodes vaporariorum Toxicity Determination
2.1 test method
Adopt spray-on process.Choose the consistent examination worm of physiological status with writing brush and be no less than 30 and put into culture dish, place the Potter spray tower to try to get to the heart of a matter in culture dish again and quantitatively spray, spray value is 1ml, takes out the examination worm behind the soup sedimentation 1min and raises.Every processing repeats for many 4 times, and establishes blank.Handle 96 worm of inspection examination as a child death condition.
2.2 experimental result
Can find out that by last table penta pyrrole worm guanidine and composite its co-toxicity coefficient of each ratio of cyanogen insect amide all are higher than 120; Explain that these two kinds of compositions have raising clearly to the preventive effect of cucumber trialeurodes vaporariorum after composite; This shows; Two kinds of compositions are composite has than obvious synergistic effect for this, have application promise in clinical practice.
3, the Toxicity Determination of penta pyrrole worm guanidine and azoles insect amide antagonism diamond-back moth
3.1 test method
Adopt and to soak the method that connects worm behind the leaf earlier, the of the same size fresh cabbage leaves that does not contact any medicament flood taking-up behind the 5s, dries naturally in the soup that configures, put into insect box; Connect then and supply examination diamondback moth larvae in 3 age, under 25 degree conditions, raise, every processing repeats for 3 times; The every repetition is provided with blank simultaneously with 30 of examination worms, the dead borer population of inspection behind the 72h; Calculate lethality and corrected mortality, obtain regression equation, calculate LC50 and co-toxicity coefficient.
3.2 result of the test
Visible by last table, in the different proportion of penta pyrrole worm guanidine and azoles insect amide, its co-toxicity coefficient has showed obvious synergistic effect all greater than 120, and wherein with penta pyrrole worm guanidine: its synergistic effect was the most obvious when the azoles insect amide was 1:10.
4, penta pyrrole worm guanidine and flonicamid are to the indoor virulence test of apple yellow aphid
4.1 test method
Adopt the leaf butterfly spray-on process, choose the consistent cabbage leaves of growth, make leaf butterfly with the card punch of diameter 18mm, 3 leaf butterflies of every ware, 30 apple yellow aphids of every leaf butterfly, every processing repetition 4 times, and establish blank.Check dead borer population in 72h, calculate lethality and corrected mortality, ask virulence regression equation and co-toxicity coefficient.
4.2 result of the test
Can find out by above-mentioned result of the test; Penta pyrrole worm guanidine and flonicamid are mixed, and more single agent all increases to the preventive effect of apple yellow aphid in the back; The co-toxicity coefficient of its each mixed ratio all is higher than 120, explains that the composite back of these two kinds of compositions has very strong synergistic effect to the control of sucking mouth parts apple yellow aphid.
Field experiment embodiment
Carry out field medicine effect test with embodiment 1-13 gained complex preparation and the single agent of each component.Select calm no rainy day gas to make an experiment, do not have rainfall in all stage of investigation, and before experiment, test back investigation in 1,3,7 day insect pest situation, according to following formula calculating drug effect:
Preventive effect (%)=1-(insect population is counted insect population number behind the * treatment region medicine before the blank medicine)/(before and after the blank medicine before mouthful number * treatment region medicine insect population number)
Result of the test is following:
1, penta pyrrole worm guanidine flonicamid composition is to the cotten aphid field trial
Table 1 51% penta pyrrole worm guanidine flonicamid suspending agents are to the control efficiency of cotten aphid
Can find out by last table; 51% penta pyrrole worm guanidine flonicamid suspending agents are significantly improved than each single agent to the preventive effect of cotten aphid; When consumption is lower, also shown suitable and better preventive effect, explained that there is obvious synergistic effect the composite back of these two kinds of compositions of penta pyrrole worm guanidine and flonicamid to the control of cotten aphid with the agent of high-load list.
2, penta pyrrole worm guanidine fipronil bisamide composition is to the field trial of wild cabbage diamond-back moth
Table 2 16% penta pyrrole worm guanidine fipronil bisamide suspension agents are to the control efficiency of wild cabbage diamond-back moth
Can find out by last table; When 16% penta pyrrole worm guanidine fipronil bisamide suspension agents use than each single agent the preventive effect of wild cabbage diamond-back moth all obviously preventive effect want high, explain that these two kinds of compositions of penta pyrrole worm guanidine and fipronil bisamide have obvious synergistic effect to the control of wild cabbage diamond-back moth after composite.
3, penta pyrrole worm guanidine and cyanogen insect amide compound are to the field trial of rice fulgorid
But table 3 25% penta pyrrole worm guanidine cyanogen insect amide dispersed oil suspending agents are to the control efficiency of rice fulgorid
Visible by last table; Control efficiency to rice fulgorid after penta pyrrole worm guanidine and cyanogen insect amide are composite obviously improves; Reducing greatly with its usage amount under the preventive effect; Therefore penta pyrrole worm guanidine and cyanogen insect amide two compositions are composite has obvious synergistic effect to the rice fulgorid control afterwards, helps reducing the medicament usage amount and improves preventive effect.
4, penta pyrrole worm guanazole insect amide composition is to the field trial of diamond-back moth
Table 4 50% penta pyrrole worm guanazole insect amide dry suspending agents are to the diamond-back moth field experiment
Can find out by last table; Penta pyrrole worm guanidine and multiple killing teichomycin compound obviously increase the preventive effect of diamond-back moth; And consumption also all has minimizing than two single agent, explains that the composite control efficiency to diamond-back moth of these two kinds of compositions has obvious synergistic effect, can also delay and administer the resistance problem of diamond-back moth simultaneously.
Comprehensive above several field experiment conclusions can be found out; After any composition in penta pyrrole worm guanidine of the present invention and flonicamid, fipronil bisamide, cyanogen insect amide, the azoles insect amide is composite controlling object all there is obvious synergistic effect; Greatly reduce the usage amount of active ingredient under the equal control efficiency, thereby reduced the harm of environment and the resistance that has delayed insect.
Comprehensive above result of the test can be found out; In penta pyrrole worm guanidine and flonicamid proposed by the invention, cyanogen insect amide, azoles insect amide, the fipronil bisamide any carry out composite after; Its control efficiency to agricultural insect pest obviously improves, and has not only reduced the usage amount of active ingredient, has also increased the control spectrum; Various pests in the agricultural all there is desirable control efficiency, is worth in the practical application of land for growing field crops, promoting.
Claims (10)
1. pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine, it is characterized in that: comprise active components A: penta pyrrole worm guanidine and active component B, active component B is: any one in flonicamid, fipronil bisamide, cyanogen insect amide or the azoles insect amide.
2. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 1 is characterized in that: the part by weight of active components A and active component B is 50:1-1:50.
3. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 2 is characterized in that: the weight ratio of active components A and active component B is preferably 20:1-1:20.
4. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 1 is characterized in that: also contain normally used auxiliary agent in the pesticidal preparations, solvent, carrier auxiliary element to make the formulation that various suitable agriculturals are used.
5. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 4 is characterized in that: said auxiliary agent is one or more among dispersant NNO, lauryl sodium sulfate, Dispersant MF, sodium lignin sulfonate, polyvinyl alcohol, agricultural newborn 600#, AEO, NPE, APES phosphate, naphthalene sulfonic acid formaldehyde condensation polymer, ammonium sulfate or the agricultural newborn 500#.
6. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 4 is characterized in that: said solvent is one or more in ethylene glycol, dimethyl formamide or the ethyl acetate.
7. the pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine according to claim 4 is characterized in that: said carrier is one or more in white carbon, kaolin, precipitated calcium carbonate, potter's clay or the water.
8. according to claim claim 1 or the 4 described pesticide synergistic Pesticidal combinations that contain penta pyrrole worm guanidine, it is characterized in that: but described formulation has wetting powder, water dispersible granules, suspending agent dispersed oil suspending agent, ultra low volume liquids, dry suspending agent.
9. according to claim 1 or the 4 described pesticide synergistic Pesticidal combinations that contain penta pyrrole worm guanidine, it is characterized in that: be applicable to spraying, dress seed, soak root, soak seed, smear, irritate and execute various occupation modes.
10. the described pesticide synergistic Pesticidal combination that contains penta pyrrole worm guanidine of claim 1-9, it is characterized in that: be used for preventing and treating the various pests on the agricultural various crop, described insect mainly comprises lepidoptera pest and sucking mouth parts class pest.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102939988A (en) * | 2012-11-29 | 2013-02-27 | 合肥星宇化学有限责任公司 | Pesticide composite compounded of Wubichonggua and dinotefuran and preparation and application thereof |
| CN103109840A (en) * | 2013-01-15 | 2013-05-22 | 合肥星宇化学有限责任公司 | Acaricidal composition containing penta-imidacloprid guanidine and spirodiclofen and preparation thereof |
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| CN102308839A (en) * | 2011-10-11 | 2012-01-11 | 合肥星宇化学有限责任公司 | Insecticidal composition and its preparation and application |
| CN102308836A (en) * | 2011-10-11 | 2012-01-11 | 合肥星宇化学有限责任公司 | Insecticidal composition and its preparation and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102308839A (en) * | 2011-10-11 | 2012-01-11 | 合肥星宇化学有限责任公司 | Insecticidal composition and its preparation and application |
| CN102308836A (en) * | 2011-10-11 | 2012-01-11 | 合肥星宇化学有限责任公司 | Insecticidal composition and its preparation and application |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939988A (en) * | 2012-11-29 | 2013-02-27 | 合肥星宇化学有限责任公司 | Pesticide composite compounded of Wubichonggua and dinotefuran and preparation and application thereof |
| CN103109840A (en) * | 2013-01-15 | 2013-05-22 | 合肥星宇化学有限责任公司 | Acaricidal composition containing penta-imidacloprid guanidine and spirodiclofen and preparation thereof |
| CN103109840B (en) * | 2013-01-15 | 2015-05-20 | 合肥星宇化学有限责任公司 | Acaricidal composition containing penta-imidacloprid guanidine and spirodiclofen and preparation thereof |
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