CN107496476A - The beneficial liver effect of yunna cowparsnip and application technology - Google Patents
The beneficial liver effect of yunna cowparsnip and application technology Download PDFInfo
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- CN107496476A CN107496476A CN201710903269.4A CN201710903269A CN107496476A CN 107496476 A CN107496476 A CN 107496476A CN 201710903269 A CN201710903269 A CN 201710903269A CN 107496476 A CN107496476 A CN 107496476A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
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- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
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- Molecular Biology (AREA)
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Abstract
The invention discloses purposes of the yunna cowparsnip in beneficial liver effect product is prepared.With the root (turniplike cowparsnip root) of the yunna cowparsnip of samphire for raw material, all kinds of high-quality beneficial liver products, including the edible health product of human and animal, herbal cuisine and natural drug product and herbal cuisine product can be effectively converted to by extraction process and processing technology.
Description
Technical field
The present invention relates to the process technology of the plant yunna cowparsnip acted on beneficial liver and in food, health food, natural
Purposes in medicine, animal health products and veterinary drug, it is dry turniplike cowparsnip root, deep processing and extract preparation side specifically
Purposes in liver-protecting efficacy health products and herbal cuisine is prepared of method, deep processed product, active chemical, turniplike cowparsnip root, yunna cowparsnip
The application of application and animal benefit liver product of the root in the medicine for preparing hepatitis.
Background technology
Liver is one of most important Functional tissue in human and animal's body, and everyone is required for liver health care.Liver
Cell subjects substantial amounts of biochemistry treatment and processing work daily, and the food and feed largely absorbed through alimentary canal is entered
The various processing metabolism of row, is very easy to fatigue and by various pathogenic former damages.Hepar damnification is to seriously endanger people
The disease of people's health, and the hepatic injury being currently known causes a disease original with thousands of kinds.China has more than the B-type hepatitis of 100,000,000 people at present
Malicious lifelong carrier, the carrier of tens million of HCVs.In recent years by being addicted to drink, medicine and various adverse factors and cause
Poisoning hepar damnification also increase increasingly.Tens of millions of people can be transformed into chronic hepatitis, hepatic sclerosis, liver cancer in hepatopath, often
Dead people there are about hundreds of thousands of them year because of hepatopathy.It is Chinese to be used to treat the costly up to tens billion of yuans of hepatopathy every year,
Very big burden is caused to the physical and mental health of economy and social development particularly patient, so keeping the health of liver turns into people
The target pursued.Food and herbal cuisine, the health food and new drug that exploitation is beneficial to liver health are just very urgent.
Yunna cowparsnip (Heracleum rapula Franch.)：For samphire, also referred to as Heqing levisticum.Yunna cowparsnip is west
The Yamoniang of southern minority area, root are to use position.Turniplike cowparsnip root has relieving cough and asthma, wind-damp dispelling, analgesic effect.
For chill cough and asthma, arthralgia pain due to rheumatism, epigastric pain.The present invention be exactly be found that turniplike cowparsnip root edible, food, health food,
Liver protection new application, processing method in herbal cuisine and medicine and the active ingredient that contains etc..
The content of the invention
It is an object of the invention to provide the new application of turniplike cowparsnip root, that is, is preparing hepatitis treatment medicine, health food and moving
New opplication in thing benefit liver product.
It is a further object of the present invention to provide a kind of natural national medicine of hepatitis treatment.
It is also another object of the present invention to provide a kind of health food of hepatitis auxiliary treatment.
The purpose of the present invention also includes providing the white clouds flower extract and its preparation that preparation is convenient, health care and therapeutic effect are good
Method.
Inventor has carried out substantial amounts of deep processing to turniplike cowparsnip root according to the processing method of Chinese medicine and studied, including yunna cowparsnip
Root medicine materical crude slice, turniplike cowparsnip root powder, turniplike cowparsnip root wine, turniplike cowparsnip root meat soup, turniplike cowparsnip root flu herbal cuisine soup, turniplike cowparsnip root liver toxin expelling
Herbal cuisine soup, turniplike cowparsnip root extract etc..
Turniplike cowparsnip root can be used for the flavor adjuvant of food in the form of medicine materical crude slice and dry powder, can be used alone, can also
Compounding use.For example the pulvis flavorant such as five-spice powder class, Thirteen Spice class can increase white clouds pollen.
Inventor's reference《2003 annual drug research technological guidance principle-Chinese medicines, natural goods fascicle》(state food medicine
Product Surveillance Authority 2003),《New drug preclinical study guideline》(national Bureau of Drugs Supervision 1993) and《Function of health food
Learn assessment process》The drug evaluation method and health food evaluation method of the hepatitis treatment of (Ministry of Public Health 2003) etc., dialogue
Cloud flower has carried out extract preparation, pharmaceutical dosage form preparation, animal pharmacology and pathological study.
The preparation method of turniplike cowparsnip root extract is：Turniplike cowparsnip root medicine materical crude slice 1000g can be taken, is added water to cook three times, every time
15 minutes, collecting decoction, filtration, after filtrate is concentrated and dried (sprayable drying), fine powder processed, produce.This product is the particle of brown,
It is savory.
Inventor has found, is administered orally with white clouds flower extract and drug administration by injection, there is obvious effect, serum liver
Dirty biochemical function index and pathological index all improve significantly.
When being treated with white clouds flower extract, it can be with pulvis, granule, tablet, capsule, pill and liquid preparation
It is administered orally etc. form；Can also in the form of parenteral solution, suppository, percutaneous preparation, spray etc. parenteral administration.Yunna cowparsnip extracts
The effective agent of thing, it is by mixing and matching somebody with somebody with appropriate medicinal blend, such as excipient, adhesive, bleeding agent, lubricant
It is manufactured.
Yunna cowparsnip extract doses change with route of administration, the age of patient and body weight.In the case of oral administration, agent
Amount is usually adult 300~600mg/ days, preferably 450mg/ days.In terms of health food and food applications and equally
Principle.
It is an advantage of the invention that：The beneficial liver therapeutic action of yunna cowparsnip is all at home and in the world to find first.Yunna cowparsnip
Can be as the natural drug for the treatment of hepatitis.
In addition, yunna cowparsnip preparation method is fairly simple, also comparing for plant growth the characteristic study is thorough, can also form one
The plantation of set pattern mould, so the source of material and economy are all secure.The market recognition of natural products is higher, market
Acceptance is high, good market prospect.
Embodiment
Examples provided below is used for that the present invention is furture elucidated, and is not meant to limit the scope of the invention.
The material of embodiment 1.
Yunna cowparsnip medicine materical crude slice used in embodiment is that pharmacy and medicinal material market Chinese medicine supplier buy.
Other medicines, reagent and experimental animal, can be easily purchased in market.
The preparation method example of embodiment 2.
Yunna cowparsnip medicine materical crude slice 1000g is taken, adds water 2500ml to decoct, altogether three times, 15 minutes every time, collecting decoction, filtration, filtrate
It is concentrated to dryness, crushes to obtain brown fine powder.Can also be sprayed to obtain fine powder.
The example of formulations of embodiment 3.
(1) the turniplike cowparsnip root extract for taking the preparation method of 1kg embodiments 2 to obtain, add appropriate amount of starch and mix, preparation
Granula, dispensed after whole grain, every bag of 2g.
(2) the turniplike cowparsnip root extract 1000g that the preparation method of Example 2 obtains, hydroxyethyl cellulose 10g, tabletting
Tablet is made.
(3) the turniplike cowparsnip root extract that the preparation method of embodiment 2 obtains is dissolved in physiological saline or isotonic Glucose Liquid, passes through
On demand using the parenteral solution prepared after filtering.
(4) the turniplike cowparsnip root extract that the preparation method of embodiment 2 obtains is dissolved in water, can be formulated directly into oral liquid.
(5) the turniplike cowparsnip root extract that the preparation method of embodiment 2 obtains can be used alone.It can also be carried with desert beans
Take the medicines such as thing, eryuelan extract to coordinate and compound mixture is made for preventing and treating hepatitis.
(6) the turniplike cowparsnip root extract powder that the preparation method of embodiment 2 obtains mixes with other seasoning powders, can be direct
It is configured to herbal cuisine soup stock.
The preparation of active ingredient monomeric compound in the turniplike cowparsnip root extract of embodiment 4.
Turniplike cowparsnip root water extract is extracted with chloroform successively, there must be liver-protecting activity stream after silica gel column chromatography separates
After part, then through the collections such as preparative high-performance liquid chromatographic purification, obtain sphondin (sphondin).
The beneficial liver effect experiment of embodiment 5.
(1) evaluation method
The drug efficacy study part of turniplike cowparsnip root extract for treating hepatitis
Experimental animal is adult healthy male CD-1 mouse.Enough running water and normal diet are provided during experiment.Will
Mouse is grouped at random by body weight.To be administered for three days on end in being observed in the effect of toxic hepatitis, once a day.Take blood within 4th day
With leave and take animal's liver, determine the liver function enzyme alanine transaminase (ALT) in serum, observe hepatic pathology intensity of variation.Experiment
Data are represented with mean ± standard deviation.The methods of being examined using EXCEL statistical softwares to experimental result using variance analysis, t point
Analysis is handled, p<0.05 thinks that group difference has conspicuousness.
(2) evaluation result (table 1, table 2, table 3)：Yunna cowparsnip and sphondin have the beneficial liver of significant anti-toxic hepatitis
Effect.
The anti-carbon tetrachloride acute toxic hepatitis effect of the yunna cowparsnip of table 1
Note：##The p ﹤ 0.01 compared with control group.* the p ﹤ 0.05 compared with hepatitis group of being poisoned.
The anti-carbon tetrachloride acute toxic hepatitis effect of the sphondin of table 2
Note：#The p ﹤ 0.05 compared with control group.* the p ﹤ 0.05 compared with hepatitis group of being poisoned.
The effect of the anti-paracetamol toxic hepatitis of the white clouds flower extract of table 3
Note：##The p ﹤ 0.01 compared with control group.* p ﹤ 0.01 compared with toxic hepatitis group.
Claims (7)
1. there is the plant product of beneficial liver effect for preparing to human and animal, it is characterised in that containing turniplike cowparsnip root or its carry
Take thing.
2. a kind of white clouds flower extract, it is characterised in that prepare with the following method, take turniplike cowparsnip root medicine materical crude slice, add water to cook
Three times, every time 15 minutes, collecting decoction, filtration, after filtrate is dried, fine powder is made.
3. white clouds flower extract according to claim 2, it is characterised in that extract fine powder and appropriate medical dressing one
A variety of formulations such as oral formulations, injection, granule, tablet, capsule, pill, powder can be made by rising.Can also with it is other
Medicine or other plant extracts compatibilities composition compound preparation.
4. a kind of medicine for hepatitis preventing and treating, it is characterised in that contain the turniplike cowparsnip root described in claim 1 and 2 or extraction
Thing.
5. a kind of health products for beneficial liver, it is characterised in that contain the turniplike cowparsnip root or extract described in claim 1 and 2.
6. the application of yunna cowparsnip or extract in the medicine and health products for preparing hepatitis described in claim 1 and 2.
7. application of the turniplike cowparsnip root or extract described in claim 1 and 2 in herbal cuisine is prepared.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113069445A (en) * | 2021-05-11 | 2021-07-06 | 重庆医科大学 | Application of bovine ledebouriella seseloides as effective component in preparing medicine for treating hepatitis B |
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