CN105477312B - The Chinese medicine composition for treating chicken colibacillosis - Google Patents

The Chinese medicine composition for treating chicken colibacillosis Download PDF

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CN105477312B
CN105477312B CN201510984392.4A CN201510984392A CN105477312B CN 105477312 B CN105477312 B CN 105477312B CN 201510984392 A CN201510984392 A CN 201510984392A CN 105477312 B CN105477312 B CN 105477312B
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radix
chicken
minutes
boiling
honeysuckle
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CN105477312A (en
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刘朝阳
刘国立
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Shijiazhuang Jiuzhou Veterinary Drug Co Ltd
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Shijiazhuang Jiuzhou Veterinary Drug Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

A kind of Chinese medicine composition for treating chicken colibacillosis, it is characterised in that it includes land plaster 50g, honeysuckle 20g, root bark of tree peony 10g, Radix Paeoniae Alba 10g, radix scutellariae 12g, Radix Salviae Miltiorrhizae 10g, dandelion 10g, bark of ash 10g, radix rehmanniae recen 10g, radix scrophulariae 10g, Radix Ophiopogonis 15g, coptis 20g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 8g；The present invention takes into account antibacterial, removing vivotoxin, reduces many-sided effects such as Drug Resistance of E. coli, treatment sore myogenic and promotion appetite.

Description

The Chinese medicine composition for treating chicken colibacillosis
Technical field
The present invention relates to fowl poultry kind disease field of traditional Chinese medicine preparations, and in particular to a kind of Chinese traditional medicine composition for treating chicken colibacillosis Object.
Background technique
Enteropathogenic E. Coli is one of most common pathogen in veterinary science clinical infection, enteropathogenic E. Coli 1 year The four seasons can cause a disease, and as aquaculture industry of China intensive degree is continuously improved, fashion trend of the livestock and poultry Escherichia coli in various regions becomes In serious.Wherein, the disease incidence of chicken is about 10%-70%, and the death rate is about 5%-75%, by unfavorable factor and other infectious agents Stress the livestock and poultry masses, coli-infection occupy always the first, this seriously affects the development of China's animal husbandry.
Antibacterials and bacillus coli vaccine are widely used, while promoting scale, intensive animal husbandry development, Also animal products drug residue is brought, the problems such as antibiotic is exceeded, this directly contributes the acute and chronic poisoning of consumer, Er Qiehui Adverse effect is generated to the normal flora in human intestine, endangers human health.
Furthermore the long-time service of antibacterials and bacillus coli vaccine is also continuously improved the drug resistance of Escherichia coli, resist Bacterium medication effect significantly reduces.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of simple process, the chicken colibacillosis death rate is effectively reduced Treatment chicken colibacillosis Chinese medicine composition.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
A kind of Chinese medicine composition for treating chicken colibacillosis, prescription are as follows: land plaster 50g, honeysuckle 20g, the root bark of tree peony 10g, Radix Paeoniae Alba 10g, radix scutellariae 12g, Radix Salviae Miltiorrhizae 10g, dandelion 10g, bark of ash 10g, radix rehmanniae recen 10g, radix scrophulariae 10g, Radix Ophiopogonis 15g, the coptis 20g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 8g；
It is prepared according to the following steps:
15 taste medicine of step 1 or more is in addition to honeysuckle, radix scutellariae, remaining 13 taste medicine is added warm water and impregnates, and water is to submerge Drug is simultaneously limited more than 4 centimetres, impregnates 60 minutes；After heating 30 minutes, honeysuckle, radix scutellariae is added, continues to be heated to boiling, boils Continue heating 20 minutes after rising, filters and collect filtrate；
Warm water is added in the filter residue of step 1 by step 2, and water is heated to boiling to submerge filter residue and be limited more than 1 centimetre It rises, continues heating 25 minutes after boiling, filter and collect filtrate；
Step 3 merges the filtrate of step 1 and step 2, and it is spare that heating is concentrated into 500ml.
Clinical trial of the invention is as follows:
Clinical test one:
(1) test method
1. the healthy chick 120, average weight 0.6kg or so of 30 ages in days is chosen, ad lib drinking-water, stochastic averagina point For blank control group, positive controls, amoxicillin soluble powder control group and the high, medium and low dosage control group of the present invention；
2. escherichia coli suspension 0.8ml is injected intraperitoneally in remaining experimental group in addition to blank control group；
3. infection starts to be administered after 20 hours, and successive administration 7 days.
4. being observed during administration, recording each group clinical manifestation, and according to healing, effective, invalid, death standard judgement clinic Curative effect.
The following are grouping and each group clinical manifestation results:
Table one is grouped situation
(2) experimental result
After artificial challenge 20 hours, largely there is following symptom in infected chicken:
I. it generates heat, have difficulty in breathing, dehisce to stretch neck；
Ii. defecation is faint yellow, canescence or the green excrement for being mixed with blood；
Iii. it loss of appetite or does not eat, feather is matt and fluffy, and beak and leg are in livid purple shape；
Blank control group, chicken spirit is good, and feed is normal；
Positive controls start chicken death occur after 45 hours, massive mortality after about 70 hours, in subsequent several days, Chicken is all dead；
Amoxicillin soluble powder group, administration the 2nd day chicken death 2, administration the 3rd day chicken death 1, most of chicken Take a turn for the better from the 3rd day spirit, appetite enhancing and illness have it is substantially reduced；
Low dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, normal to feed, on day 4 when chicken Dead 1；
Middle dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, and spirit is good and feed is positive, not Occur dead；
High dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, and spirit is good and feed is positive, not Occur dead；
The chicken weight of low dose group of the present invention, middle dose group of the present invention and high dose group of the present invention increased, respectively The ratio (rate of body weight gain) that group weight gain chicken accounts for this group of chicken sum is 70%-90%；Blank control group rate of body weight gain is 95%；A Moxi Woods soluble powder group rate of body weight gain is 75%.
Following table is made in the above results:
Two experimental result of table
Clinical test two
(1) test method
1. choosing healthy chicken 120, average weight 2kg or so of 90 ages in days, ad lib drinking-water, stochastic averagina is divided into sky White control group, positive controls, amoxicillin soluble powder control group and the high, medium and low dosage control group of the present invention；
2. escherichia coli suspension 0.8ml is injected intraperitoneally in remaining experimental group in addition to blank control group；
3. infection starts to be administered after 20 hours, and successive administration 7 days.
4. being observed during administration, recording each group clinical manifestation, and according to healing, effective, invalid, death standard judgement clinic Curative effect.
Table three is grouped situation
Group Chicken number/only Processing method
Blank control group 20 Normal raising
Positive controls 20 Infection, no treatment
Amoxicillin soluble 20 Infection, 0.8g/kg mix water and control
(high dose) of the invention 20 Infection, 70ml/kg mix water and control
(middle dosage) of the invention 20 Infection, 45ml/kg mix water and control
(low dosage) of the invention 20 Infection, 20ml/kg mix water and control
(2) experimental result
After artificial challenge 20 hours, largely there is following symptom in infected chicken:
I. it generates heat, have difficulty in breathing, dehisce to stretch neck；
Ii. defecation is faint yellow, canescence or the green excrement for being mixed with blood；
Iii. it loss of appetite or does not eat, feather is matt and fluffy, and beak and leg are in livid purple shape；
Blank control group, chicken spirit is good, and feed is normal；
Positive controls start chicken death occur after 50 hours, massive mortality after about 80 hours, in subsequent several days, Chicken is most of dead；
Amoxicillin soluble powder group, at administration the 2nd day chicken death 1, most of chicken takes a turn for the better from the 3rd day spirit, appetite Enhancing and illness have substantially reduced；
Low dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, normal to feed, on day 3 when chicken Dead 1；
Middle dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, and spirit is good and feed is positive, not Occur dead；
High dose group of the present invention, when being administered the 3rd day, most of chicken situation takes a turn for the better, and spirit is good and feed is positive, not Occur dead；
The chicken weight of low dose group of the present invention, middle dose group of the present invention and high dose group of the present invention increased, respectively The ratio (rate of body weight gain) that group weight gain chicken accounts for this group of chicken sum is 80%-90%；Blank control group rate of body weight gain is 100%；Ah Amdinocillin soluble powder group rate of body weight gain is 85%.
Following table is made in the above results:
Four experimental result of table
It is concluded that in conjunction with the experimental result of clinical trial one and clinical test two
The therapeutic effect of amoxicillin soluble group and the high, medium and low dosage group of the present invention is significant, and chicken survival rate is significantly high In positive controls, wherein the present invention is high, the treated effect of middle dose group is higher than or is equivalent to amoxicillin soluble powder group； Show the Chinese medicine composition of present invention treatment chicken colibacillosis by clinical test one and clinical trial two, hence it is evident that improve chicken Illness prevents illness from further deteriorating, and promotes chicken appetite and spirit, accelerates chicken to restore, and for different growth stages Chicken colibacillosis have significant curative effect.
The beneficial effects of the present invention are:
Prescription proportion takes into account antibacterial, removing vivotoxin, reduces Drug Resistance of E. coli, treats sore myogenic and promote appetite Deng many-sided effect；And the present invention processes simplicity, medicinal material easily obtains, and is easy to use.
Specific embodiment
Embodiment one:
1. the prescription of the Chinese medicine composition of the treatment chicken colibacillosis are as follows: land plaster 50g, honeysuckle 20g, the root bark of tree peony 10g, Radix Paeoniae Alba 10g, radix scutellariae 12g, Radix Salviae Miltiorrhizae 10g, dandelion 10g, bark of ash 10g, radix rehmanniae recen 10g, radix scrophulariae 10g, Radix Ophiopogonis 15g, the coptis 20g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 8g；
2. being prepared according to the following steps:
15 taste medicine of step 1 or more is in addition to honeysuckle, radix scutellariae, remaining 13 taste medicine is added warm water and impregnates, and water is to submerge Drug is simultaneously limited more than 4 centimetres, impregnates 60 minutes；After heating 30 minutes, honeysuckle, radix scutellariae is added, continues to be heated to boiling, boils Continue heating 20 minutes after rising, filters and collect filtrate；
Warm water is added in the filter residue of step 1 by step 2, and water is heated to boiling to submerge filter residue and be limited more than 1 centimetre It rises, continues heating 25 minutes after boiling, filter and collect filtrate；
Step 3 merges the filtrate of step 1 and step 2, and it is spare that heating is concentrated into 500ml.
Main feature and beneficial effect of the invention has been shown and described above.Above-described embodiment is only of the invention preferred Embodiment, those skilled in the art for various change of the invention and change under the premise of not departing from spirit and range Into these changes and improvements are both fallen in protection scope of the present invention.

Claims (1)

1. a kind of Chinese medicine composition for treating chicken colibacillosis, it is characterised in that: it is made of following component proportion: land plaster It is 50g, honeysuckle 20g, root bark of tree peony 10g, Radix Paeoniae Alba 10g, radix scutellariae 12g, Radix Salviae Miltiorrhizae 10g, dandelion 10g, bark of ash 10g, radix rehmanniae recen 10g, profound Join 10g, Radix Ophiopogonis 15g, coptis 20g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 8g, Radix Angelicae Sinensis 8g；
It is prepared according to the following steps:
15 taste medicine of step 1 or more is in addition to honeysuckle, radix scutellariae, remaining 13 taste medicine is added warm water and impregnates, and water is to submerge drug And be limited more than 4 centimetres, it impregnates 60 minutes；After heating 30 minutes, honeysuckle, radix scutellariae is added, continues to be heated to boiling, after boiling Continue heating 20 minutes, filters and collect filtrate；
Warm water is added in the filter residue of step 1 by step 2, and water is heated to boiling to submerge filter residue and be limited more than 1 centimetre, Continue heating 25 minutes after boiling, filters and collect filtrate；
Step 3 merges the filtrate of step 1 and step 2, and it is spare that heating is concentrated into 500ml.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102552656A (en) * 2012-01-19 2012-07-11 青岛康地恩药业股份有限公司 Chinese medicinal composition for treating chicken colibacillosis
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