CN102988490A - Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis - Google Patents
Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis Download PDFInfo
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention belongs to the technical field of veterinary medicines, particularly relates to an application of Shuanghuanglian oral liquor in preparation of a medicine for treating and preventing poultry virosis, and in particular relates to an application of Shuanghuanglian oral liquor in preparation of a medicine for treating and preventing newcastle disease or infectious bronchitis. As the experiments show, the Shuanghuanglian oral liquor has an excellent effect on immunological enhancement respect to newcastle disease and infectious bronchitis bivalent inactivated vaccines (LaSota-M41 strains), can be used for obviously improving the antibody level as well as the immune protective effects of the newcastle disease and infectious bronchitis bivalent inactivated vaccines (LaSota-M41 strains), and also can be used for improving the infectious bronchitis virus serum antibody titer, and as a result, the anti-excitability ability of the poultry organisms is improved.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to the application of a kind of SHUANGHUANGLIAN KOUFUYE in preparation treatment and prevention poultry virus disease medicament.
Background technology
Viral disease is particularly maximum, the class disease the most rambunctious of aviculture harm of aquaculture always, is having a strong impact on the development of China's aquaculture.Such as: the viral disease of chicken being widely current worldwide, caused serious economic loss to poultry husbandry, be to endanger now one of the most serious epidemic disease of poultry farming.That especially serious is bird flu virus direct infection people and the causing death who repeatedly occurs recent years.The becoming increasingly complex of bacterial disease of livestock and poultry viral disease and or secondary concurrent by virosis in recent years, antibiotic use is so that classical symptom is more and more not obvious, and mortality rate reduces gradually, but the carriers rate is very high, in case extraneous inducement is arranged, is easy to cause morbidity.The at present prevention of poultry virus disease is mainly by vaccine, morbidity is rear without special effect medicine therapeutic, the curative of suiting the medicine to the illness is also mainly take chemicals as main, as the treatment of infectious bronchitis of chicken and infectious laryngotracheitis being adopted more the medicines such as antibiotics tilmicosin, chlortetracycline, lincomycin, spectinomycin, florfenicol, to preventing that secondary infection from having certain curative effect, but only take stopgap measures and do not effect a permanent cure.
China's herbal medicine history is long, plays guaranteeing role for the animal husbandry development of China for thousands of years.For the viral disease that accounts for major part in the livestock and poultry and bacterial disease, herbal medicine also has multi-faceted adjusting and therapeutical effect concurrently, can improve immunity and the anti-stress ability of animal body, promotes the performance of fertility performance.The compound recipe dosage form that SHUANGHUANGLIAN KOUFUYE is comprised of Chinese medicine extract, the Radix Scutellariae bitter in the mouth is cold in nature in the side, can clearing away heat-fire, especially take eliminating the pathogens from the lung through the heat of edema caused by disorder of QI as its chief; Flos Lonicerae, the Fructus Forsythiae property of medicine are cold and cool, and the effect of stronger heat-clearing and toxic substances removing is arranged, and Flos Lonicerae can dispelling wind-heat, kind removing summer-heat blood poison also, and the Fructus Forsythiae bitter cold is held concurrently hot, and the power of the loose pathogenic factor in the exterior of a surname, all heat of removing summer-heat is arranged.
Summary of the invention
The object of the invention is to provide the application of SHUANGHUANGLIAN KOUFUYE in preparation treatment and prevention poultry virus disease medicament.
For achieving the above object, the present invention adopts following technical scheme:
The application of SHUANGHUANGLIAN KOUFUYE in preparation treatment and prevention poultry virus disease medicament.Described poultry virus disease mainly refers to the poultry disease that caused by viral infection specifically comprise newcastle, bird flu, infectious bronchitis, infectious laryngotracheitis, infectious bursal disease, fowlpox, duck viral hepatitis, gosling plague etc.
Preferably, the application of SHUANGHUANGLIAN KOUFUYE aspect preparation treatment and prevention newcastle disease or infectious bronchitis of chicken medicine.
SHUANGHUANGLIAN KOUFUYE of the present invention can be used by drinking-water or the mode that gavages, and concrete mode is: every 1ml SHUANGHUANGLIAN KOUFUYE is watered 1L, and poultry is freely drunk; Or every poultry 1ml, drip gavages.
The method preparation that SHUANGHUANGLIAN KOUFUYE of the present invention provides according to Chinese veterinary pharmacopoeia second one of version in 2010, concrete steps are as follows:
1) extracting honeysuckle 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g.More than three flavors, Radix Scutellariae section decocts with water 3 times, the 1st 2h, the 2nd, 3 each 1h, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value in right amount to 1.0-2.0, insulation 1h, leave standstill 12h, filter, precipitation adds 6-8 times of water gaging, transfers to pH value to 7.0 with 40% sodium hydroxide solution, the ethanol that adds again equivalent, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with 2mol/l hydrochloric acid, 60 ℃ of insulation 30min, leave standstill 12h, filter, precipitation adds ethanol and is washed till pH value 7.0, wave most ethanol, for subsequent use.
2) Flos Lonicerae, Fructus Forsythiae add water temperature and soak 30min, decoct 2 times, each 1.5h, collecting decoction filters, and it is 1.2-1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain the alcohol amount and reach 75%, fully stir, leave standstill 12h, leaching supernatant, residue add 75% appropriate amount of ethanol, stir evenly, leave standstill 12h, filter, merge ethanol, Recycled ethanol is to distinguishing the flavor of without alcohol.Add above-mentioned Radix Scutellariae extract, and it is an amount of to add water, with 40% sodium hydroxide solution adjust pH to 7.0, stirs evenly, cold preservation (4-8 ℃) 72h filters, and filtrate is regulated ph value to 7.0, adds water and makes 1000ml, stirs evenly, and leaves standstill 12h, filter, and fill, sterilization, and get final product.
SHUANGHUANGLIAN KOUFUYE belongs to flu class nonprescription drugs medicine, is mainly used in treating that affection due to external wind and heat type flu causes has a headache and fever, the symptoms such as cough and pharyngalgia.Innovative point of the present invention has been to find the new purposes of SHUANGHUANGLIAN KOUFUYE aspect preparation treatment and prevention poultry virus disease medicament.Below in conjunction with the specific embodiment SHUANGHUANGLIAN KOUFUYE of the present invention is being prepared treatment and preventing the application in the poultry virus disease medicament to explain.
The specific embodiment
SHUANGHUANGLIAN KOUFUYE is tested the impact of newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain-M41 strain) antibody horizontal:
1. experimental animal: 250 20 age in days Luo Man chickling are purchased from Zhengzhou positive moral kind chicken house.
2. medicine is used in test: newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain-M41 strain) are purchased from Qilu Animal Health Products Co., Ltd., product batch number: 1105003.SHUANGHUANGLIAN KOUFUYE (the method preparation that provides according to Chinese veterinary pharmacopoeia second one of version in 2010), Henan Xinzhenghao Bio-Engineering Co., Ltd. produces, lot number 120302.Astragalus polysaccharides oral liquid: be purchased from Ai Disen (Beijing) bio tech ltd, lot number 20110901.The sick ELISA antibody test of avian infectious bronchitis virus diagnostic kit is available from Shenzhen Lvshiyuan Biotechnology Co., Ltd., lot number: 20110606.
Test is divided into 5 groups, every group of 50 chickens, and specifically grouping and test of cure method see the following form 1.Each organize the child care measure and feeding and management identical, free choice feeding and drinking-water, whole experimental period on every Mondays, five thoroughly clean sterilization, observe searching for food and growing of chicken.
The grouping of table 1 test chicken and processing
| Group | Test method | Usage, consumption and the course for the treatment of |
| The vaccine matched group | Inoculative infection bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) | Subcutaneous injection newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) 0.3ml |
| Low dose group | Inoculative infection bronchitis bigeminy killed vaccine (La Sota strain+M41 strain)+SHUANGHUANGLIAN KOUFUYE | Subcutaneous injection newcastle disease, the every 1L water of infectiousness bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) 0.3ml+ add the 0.5ml SHUANGHUANGLIAN KOUFUYE, freely drink water 5 days |
| Middle dosage group | Inoculative infection bronchitis bigeminy killed vaccine (La Sota strain+M41 strain)+SHUANGHUANGLIAN KOUFUYE | Subcutaneous injection newcastle disease, the every 1L water of infectiousness bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) 0.3ml+ add the 1ml SHUANGHUANGLIAN KOUFUYE, freely drink water 5 days |
| High dose group | Inoculative infection bronchitis bigeminy killed vaccine (La Sota strain+M41 strain)+SHUANGHUANGLIAN KOUFUYE | Subcutaneous injection newcastle disease, the every 1L water of infectiousness bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) 0.3ml+ add the 1.5ml SHUANGHUANGLIAN KOUFUYE, freely drink water 5 days |
| The medicine matched group | Inoculative infection bronchitis bigeminy killed vaccine (La Sota strain+M41 strain)+astragalus polysaccharides oral liquid | Subcutaneous injection newcastle disease, the every 1L water of infectiousness bronchitis bigeminy killed vaccine (La Sota strain+M41 strain) 0.3ml+ add the 1ml astragalus polysaccharides oral liquid and freely drank water 5 days |
Each test group and matched group respectively at vaccination before 1d and the inoculation after the 5th, 15, the 30d blood sample collection, carry out the avian infectious bronchitis virus antibody horizontal with the sick ELISA antibody test of avian infectious bronchitis virus diagnostic kit and detect, concrete operation method carries out according to the test kit description.
3. result of the test: newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain-M41 strain) antibody horizontal testing result see Table 2.
As seen from Table 2, each the test group chicken antibody that records before immunity inoculation is on close level.From immunity inoculation 5d, the IHA antibody titer level of the basic, normal, high dosage group of SHUANGHUANGLIAN KOUFUYE chicken all is significantly higher than vaccine matched group (P＜0.05), and the antibody of the basic, normal, high dosage group of SHUANGHUANGLIAN KOUFUYE chicken generation speed is fast, longer duration.Significant difference (P＜0.05) in twos between the basic, normal, high dosage group of SHUANGHUANGLIAN KOUFUYE and the astragalus polysaccharides oral liquid medicine matched group, illustrate when freely drinking water, add 0.5ml, 1ml in the 1L water, the 1.5ml SHUANGHUANGLIAN KOUFUYE has obvious facilitation to the generation of avian infectious bronchitis virus antibody, the raising of immune disease-resistance ability.
4. conclusion (of pressure testing):
1) SHUANGHUANGLIAN KOUFUYE has good immunological enhancement to newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain-M41 strain); compare with astragalus polysaccharides oral liquid; can significantly improve the antibody horizontal (p＜0.05) of newcastle disease, infectiousness bronchitis bigeminy killed vaccine (La Sota strain-M41 strain); strengthen its immanoprotection action; improve the avian infectious bronchitis virus serum antibody titer, thereby improve the anti-stress ability of poultry body.
2) according to this result of the test, recommend SHUANGHUANGLIAN KOUFUYE to press 1L water and add the mixed drink of 1ml, with the vaccine coupling, be used in conjunction 5 days, can improve the immunity of poultry body, strengthen its anti-stress ability, improve the immune protective efficiency of vaccine.
Claims (4)
1. the application of SHUANGHUANGLIAN KOUFUYE in preparation treatment and prevention poultry virus disease medicament.
2. application as claimed in claim 1 is characterized in that, described poultry virus disease is newcastle, bird flu, infectious bronchitis, infectious laryngotracheitis, infectious bursal disease, fowlpox, duck viral hepatitis or gosling plague.
3. application as claimed in claim 1 is characterized in that, the application of SHUANGHUANGLIAN KOUFUYE aspect preparation treatment and prevention newcastle disease medicine.
4. application as claimed in claim 1 is characterized in that, the application of SHUANGHUANGLIAN KOUFUYE aspect preparation treatment and prevention infectious bronchitis of chicken medicine.
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| CN105726742A (en) * | 2016-03-25 | 2016-07-06 | 华南农业大学 | Anti-neweastle disease virus and anti-avian influenza veterinary herbal medicine and preparation method thereof |
| CN106421085A (en) * | 2016-10-27 | 2017-02-22 | 成都乾坤动物药业股份有限公司 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
| CN106668177A (en) * | 2016-12-13 | 2017-05-17 | 四川喜亚动物药业有限公司 | Traditional Chinese medicine combination for chicken infectious bronchitis and preparation method thereof |
| CN108904650A (en) * | 2018-09-04 | 2018-11-30 | 广州白云山宝神动物保健品有限公司 | A kind of Shuanghuanglian oral liquid and preparation method thereof for preventing and treating infectious laryngotracheitis |
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| CN104815007B (en) * | 2015-05-13 | 2018-06-26 | 成都乾坤动物药业有限公司 | A kind of pharmaceutical composition for preventing infectious bronchitis of chicken and its preparation method and application |
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| CN106421085A (en) * | 2016-10-27 | 2017-02-22 | 成都乾坤动物药业股份有限公司 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
| CN106668177A (en) * | 2016-12-13 | 2017-05-17 | 四川喜亚动物药业有限公司 | Traditional Chinese medicine combination for chicken infectious bronchitis and preparation method thereof |
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