CN103007233B - Antibacterial and antiviral pig disease preventing and treating traditional Chinese medicine (TCM) composition - Google Patents
Antibacterial and antiviral pig disease preventing and treating traditional Chinese medicine (TCM) composition Download PDFInfo
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- CN103007233B CN103007233B CN201210581969.3A CN201210581969A CN103007233B CN 103007233 B CN103007233 B CN 103007233B CN 201210581969 A CN201210581969 A CN 201210581969A CN 103007233 B CN103007233 B CN 103007233B
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Abstract
The invention provides an antibacterial and antiviral pig disease preventing and treating traditional Chinese medicine (TCM) composition. The composition is characterized in that the composition comprises the following components in parts by weight: 15-25 parts of pinellia tuber, 10-20 parts of dangshen or ginseng or heterophylly falsestarwort root, 10-20 parts of baical skullcap root or dandelion, 10-20 parts of radix glycyrrhizae preparata, 10-20 parts of dried ginger or prepared common monkshood branched root, 5-10 parts of coptis root or turmeric root tuber or Chinese pulsatilla root, 10-20 parts of Chinese date or black date or red date and 10-20 parts of kudzuvine root or divaricate saposhnikovia root or largetrifoliolious bugbane rhizome. The composition has the advantages that aiming at different stages of pig virus infection, the prevention and treatment system of body resistance strengthening and pathogenic factor eliminating sequential intervention is adopted, and a new idea is provided for establishment of the pig disease prevention and treatment system; the immunity and resistance of pigs can be improved via active components in the TCM components such as anti-inflammatory components, anti-stress components, immune enhancers and the like; the immunity of pigs is improved to achieve the effect of pig disease prevention and treatment; the product can be widely used in pig raising production; and at present, over 80% of diseases in pig raising production are viral diseases, so the product has extensive application prospects.
Description
Technical field
the present invention relates to a kind of compositions, be specifically related to a kind of antibacterial, antiviral swine diseases control Chinese medicine composition.
Background technology
In recent years, pig disease of viral infection becomes a class frequently-occurring disease, the difficult treatment that veterinary clinic faces.At present mainly vaccination is relied on to the prevention of viral infection, because viral species is more and the reason such as virus variation, still lack vaccine with strong points at present.Therefore, such disease, once outburst, controls still there is larger difficulty; Though the clinical medicine copied for viral interference has the effect of certain control virus breeding, antiviral while, too many unknown is existed on the impact of pig subsequent growth, also considerably increase the edible risk of Carnis Sus domestica.It is many, disorderly to there is disease in current animal productiong, and drug use such as to spread unchecked at the problem, has had a strong impact on the body health of animal and the food safety of the mankind.
In order to evade above-mentioned risk, the effect of Chinese medicine in porcine viral diseases control has started the concern being subject to academia, such as Radix Isatidis, Herba Andrographis etc., they play preventive effect by kill virus, the approach such as immunity that suppresses virus breeding and/or improve pig self to disease, and therefore, Chinese medicine is that porcine viral diseases provides brand-new means of prevention, but, along with constantly pushing open of application in TCM, problem is also comed one after another, and is in particular in following aspect:
1. make feed additive with bitter cold or a certain class bias Chinese medicine for a long time, fail to embody the difference between prevention with treatment, its consequence have impact on ingesting of pig on the contrary, result in the imbalance of pig intestinal microbial population and pig to the mesotrophic effective absorption of feedstuff;
2. the prolonged application of single medicinal material additive, easily makes the drug resistance of virus generation to associated additives;
3. Chinese medicine feed additive preparation process is simple, reduces the bioavailability of medicine, wastes crude drug, increase the cost of additive, hinders actual in production practices popularization.
Porcine viral diseases is the multiple and refractory disease of a class, still lacks desirable treatment way so far.It can cause piglet dead, and become pig to lose flesh, the price of deed reduces, and increases the spending etc. of labour cost and expenses for medicine in swine rearing process, is the important diseases of harm pig industry.
Porcine viral diseases Prevention status is analyzed
1. immunoprophylaxis
At present, most viral disease has vaccine and injects to sow, and piglet obtains antibody by sucking breast milk, and therefore vaccination is one of important measures of prevention piglet morbidity.But there are problems in vaccine use: 1) lack vaccine targetedly, effectively cannot control viral disease; 2) often there is confounding factor in the generation of viral disease, only to wherein one or two kind take measures, and other factors can not get controlling, then often show as vaccine invalid or produce effects little; 3) pig of a lot of plant has been in when vaccination and has infected incubation period or infect strong malicious early stage; 4) there is variation in various degree in pathogen, and vaccine originally can not reach the immune efficacy of expection.
2. Drug therapy
Current porcine viral diseases still lacks effective medicine, but in order to prevent secondary infection, often carries out symptomatic therapy, if application enteric antiseptics is as the prevention such as furazolidone, norfloxacin secondary infection.Class of medications there is no specially good effect antiviral drugs, therefore treat time still to put prevention first.And antibiotic abuse condition is namely there is in the process of control.In pig feed, the long-term antibiosis that uses have following negative effect: the generation of bacterial drug resistance;
Immunity of livestock declines; Poultry autogenous infection and superinfection; Cause residual in livestock products and environment, produce food-safety problem.
3. Substitutes For Antibiotic application
In the process of porcine viral diseases control, Substitutes For Antibiotic has: 1) microbial ecological agent.It is the microbial inoculum that animal health bacterium produces through anaerobic fermentation.This microbial inoculum adds in feedstuff, forms advantage profitable strain in digestive tract, keeps the balance of intestinal microflora, enhancing body nonspecific immunity.2) oligosaccharide.Oligosaccharide has the effect of microecosystem regulation balance, simultaneously can immune stimulatory, raising animal disease resistant power.3) enzyme preparation.It can supplement the deficiency of endogenous enzymes, thus promotes animal digesting and assimilating nutrient, increases efficiency of feed utilization.4) Chinese medicine feed additive.Chinese herbal medicine has the effect directly suppressing virus and strengthen immunity, can promote that nutrient digestion absorbs.
Chinese medicine feed additive prescription analysis of technology status
At present, Chinese medicine feed additive uses and there is several form:
1) some discarded medicine residues are processed into feed additive: as Radix Codonopsis stem and leaf, mentha leave powder etc.2) according to the pharmacologically active formula feed additive of Chinese medicine: as much Chinese medicine has regulating action to sugar, fat, protein metabolism, piglet feed intake can be improved, improve digestive function, promote piglet growth.Someone makes fattening promoter " big porker dish " with Fructus Hordei Germinatus, Rhizoma Osmundae, Radix Polygoni Multiflori.
But, often there is following problems in the Chinese medicine feed additive prescription process lacked under therapeutic principle of traditional Chinese medicine theoretical direction: lessly when 1) Chinese medicine feed additive uses under guidance of traditional Chinese medicine theory, carries out drug screening and compatibility, put undue emphasis on the antiviral pharmacologically active of Chinese medicine, thus easily produce Chinese medicine use safety sex chromosome mosaicism; 2) Chinese medicine additive in use often exist single formula be applied to pig growth all the time, fail to apply additive according to pig physiological and pathological feature, distinguish different from the state of non-period of disease of pig period of disease, prevention effect is barely satisfactory.
Chinese medicine feed additive preparation technology As-Is analysis
The milligram ammonia and the rational processing method that lack dosage form in Chinese medicine feed additive use procedure also become the key factor restricting curative effect.Lacking suitable form of Chinese drug processing method not only causes raiser's cost to increase, the food ration of the nutrient concentration simultaneously diluting feedstuff, the mouthfeel that have impact on feedstuff and pig.Thus the important content that Chinese medicine feed additive Study on Preparation also should become Chinese medicine feed additive research is carried out.
Summary of the invention
In order to make up the above deficiency of prior art, the object of this invention is to provide a kind of antibacterial, antiviral swine diseases control Chinese medicine composition (name of product is " toxic removing is fallen apart ").The present invention is directed to the different phase of pig viral infection, adopt the countermeasure system of righting and eliminating evil sequential intervention, set up for swine diseases countermeasure system and propose new thinking.
The scheme completing foregoing invention task is, a kind of antibacterial, antiviral swine diseases control Chinese medicine composition, and it is characterized in that, the weight portion of each component is composed as follows:
Rhizoma Pinelliae 15-25,
Radix Codonopsis (or Radix Ginseng or Radix Pseudostellariae) 10-20,
Radix Scutellariae (or Herba Taraxaci) 10-20,
Radix Glycyrrhizae Preparata 10-20,
Rhizoma Zingiberis (or Radix Aconiti Lateralis Preparata) 10-20,
Rhizoma Coptidis (or Radix Curcumae or the Radix Pulsatillae) 5-10,
Fructus Jujubae (or Fructus Jujubae or Fructus Jujubae) 10-20,
Radix Puerariae (or Radix Saposhnikoviae or Rhizoma Cimicifugae) 10-20.
In the prioritization scheme of above compositions, the weight portion composition of each component is:
Rhizoma Pinelliae 18-22, Radix Codonopsis 13-17, Radix Scutellariae 13-17, Radix Glycyrrhizae Preparata 13-17, Rhizoma Zingiberis 13-17, Rhizoma Coptidis 5-8, Fructus Jujubae 13-17, Radix Puerariae 13-17.
In the preferred plan of above compositions, the weight portion composition of each component is:
The Rhizoma Pinelliae 20, Radix Codonopsis 15, Radix Scutellariae 15, Radix Glycyrrhizae Preparata 15, Rhizoma Zingiberis 15, Rhizoma Coptidis 6, Fructus Jujubae 15, Radix Puerariae 15.
In the scheme more optimized, each component of above Chinese medicine composition, all adopts the crude drug in whole being crushed to less than 10 μm.
Use modern superfine communication technique, crude drug in whole can be crushed to less than 10 μm, under this fineness condition, the sporoderm-broken rate of general crude drug cell reaches more than 90%.Improve bioavailability while this technology can keep pharmacodynamic substances basis, improve medical material utilization rate.While guaranteeing curative effect, can save a large amount of medical material, Cost optimization controls.
During use, adopt above Chinese medicine composition, with the form administration of feed additive, every pig consumption every day is about 102-112g, optimum amount 106g.
The present invention is directed to the different phase of pig viral infection, adopt the countermeasure system of righting and eliminating evil sequential intervention, set up for swine diseases countermeasure system and propose new thinking.Wherein the righting commodity that use above-mentioned composition to form are all strong good, have righting spleen invigorating and promote the production of body fluid, the merit of relieving distension by promoting circulation of QI, and the traditional Chinese medical science thinks the spleen being the foundation of acquired constitution, and spleen invigorating, to pray " prevention of diseae ", improves immunity, builds up resistance.
Innovative point of the present invention:
(1) theoretical with therapeutic principle of traditional Chinese medicine is the Chinese medicine feed additive research and apply instructed, but has jumped out and prevent and treat the Traditional Thinking of the starting point to kill swine diseases poison for core;
(2) the sequential innovative idea giving series traditional Chinese feed additive, plays additive to greatest extent and prevents and treats effect;
(3) introducing of super micro crushing of Chinese medicinal material new technique, improves the bioavailability of Chinese herb, reduces the pollution to environment;
(4) best Study on Preparation makes feed additive preparation research rise to a brand-new height.
Through lab scale, pilot process checking, technological parameter is stablized, and products obtained therefrom index component content is stablized, and meets feed additive research and development requirement, mature technology.
In the verification experimental verification of small-scale swinery, use prescription of the present invention, compared with matched group, the sickness rate of viral disease reduces more than 40%, successful.
Sequential under therapeutic principle of traditional Chinese medicine theoretical direction of this product is prevented and treated based on theoretical system, according to the mechanism of porcine viral diseases morbidity and the feature of animal productiong, adopt patent compounding techniques and superfine powder processing technique, to viral disease, there is good prevention effect, overcome the drawback of traditional therapy simultaneously, with the obvious advantage.Concrete analysis sees the following form:
The present invention is based on the prevention present situation of porcine viral diseases, project team is fully realizing on the unique advantage basis that Chinese medicine additive has, enter the ultimate principle that a line has merged Chinese medicine prevention viral disease, found the new concept of relevant Chinese medicine additive research and development, absorb more preparation and use of the new technology, Chinese medicine additive R & D Level is stepped on a new stage, specifically concentrates on following aspect:
1. fully apply the correlation theory of TCM prevention and cure fever caused by exogenous pathogenic factors.
Traditional Chinese medical science fever caused by exogenous pathogenic factors theory has important directive significance to the control of viral disease, is mainly manifested in: 1) " righting, eliminating evil " theoretical with antiviral, to promote establishing of pig self diseases prevention research on function thinking vertical; 2) while sending out " effect a permanent cure at ordinary times, take stopgap measures " theoretical establishment with sequential utilization series traditional Chinese additive thinking.
2. circulate abundant Chinese medical discrimination prescription in prescription process and comply with card medication principle.
Differentiation of tcm thought refers to and adopts different Therapeutic Method for the different pattern of syndrome of disease, and the different phase for viral disease adopts different distinguishing, and the method for controlling is based upon on the judgement basis to its pattern of syndrome.Modern study also finds, the different mechanism of action distinguishing its modern medicine of the method for controlling is also different.
3. in prescription and application process thereof, have followed the relative theory of TCM Spleen gastropathy diagnosis and treatment.
Because The spleen and stomach provide the material basis of the acquired, turn round and look to protect to it and not only can improve the absorption of intestinal to nutrition, also can regulate the immunologic function of body, therefore, the conditioning to taste must be paid attention in diseases prevention and treatment process, determine " the taste unit " of Chinese medicine additive when prescription thus.
4. in preparation process elaboration process according to superfine communication technique and the pig additive formulations principle of optimality.
Study on Supermicro-pulverization of Traditional Chinese Drugs technology can increase the absorption of effective ingredient, improves the bioavailability of medicine, reduces the use amount of crude drug, reduces the use cost of Chinese medicine additive; Except medicine crushing technology, preparation process also should consider the screening of flavoring agent and the formulation etc. of production cost optimization flow process.
Based on above understanding, the theory of Chinese medicine and modern farming enterprise's are combined closely by this project, by both crossing research, for the green pig raising safety and environmental protection opens up new approach.
The present invention is directed to the different phase of pig viral infection, adopt the countermeasure system of righting and eliminating evil sequential intervention, set up for swine diseases countermeasure system and propose new thinking.The present invention keeps healthy as daily maintenence, by effective ingredient such as anti-inflammatory, anti-stress, immunostimulants in Chinese medicine ingredients, can improve immunity and the resistance of pig.Improve the immunity of pig, reach effect of swine diseases control.This product can be widely used in Swine Production.Because the disease more than 80% in current Swine Production is all viral disease, therefore, product has broad application prospects.
The present invention is by theory and technology advanced to the ideological system of Chinese medicine study, research method, processing technique etc., be applied to animal feed additive field, it is worth emphasizing that all strong good and loose two Empirical formula of antiviral toxic removing of selected immunity moderation in research, prescription is ripe, effect must confirm, give full play to the advantage of cross discipline, there is unrivaled advance.
Detailed description of the invention
Embodiment 1, feed additive, name of product is " toxic removing is fallen apart "---a kind of antibacterial, antiviral swine diseases control Chinese medicine composition.The weight portion of each component is composed as follows: the Rhizoma Pinelliae 20, Radix Codonopsis 15, Radix Scutellariae 15, Radix Glycyrrhizae Preparata 15, Rhizoma Zingiberis 15, Rhizoma Coptidis 6, Fructus Jujubae 15, Radix Puerariae 15.Each component all adopts the crude drug in whole being crushed to less than 10 μm.During use, adopt above Chinese medicine composition, with the form administration of feed additive, every pig consumption every day is about 102-112g.
Embodiment 2, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 22, Radix Codonopsis 17, Radix Scutellariae 13, Radix Glycyrrhizae Preparata 13, Rhizoma Zingiberis 17, Rhizoma Coptidis 5, Fructus Jujubae 13, Radix Puerariae 17.
Embodiment 3, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 18, Radix Codonopsis 13, Radix Scutellariae 17, Radix Glycyrrhizae Preparata 17, Rhizoma Zingiberis 13, Rhizoma Coptidis 8, Fructus Jujubae 17, Radix Puerariae 13.
Embodiment 4, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 22, Radix Codonopsis 13, Radix Scutellariae 13, Radix Glycyrrhizae Preparata 13, Rhizoma Zingiberis 17, Rhizoma Coptidis 5, Fructus Jujubae 13, Radix Puerariae 17.
Embodiment 5, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 22, Radix Codonopsis 15, Radix Scutellariae 17, Radix Glycyrrhizae Preparata 17, Rhizoma Zingiberis 13, Rhizoma Coptidis 8, Fructus Jujubae 17, Radix Puerariae 17.
Embodiment 6, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 25, Radix Codonopsis 20, Radix Scutellariae 20, Radix Glycyrrhizae Preparata 20.
Embodiment 7, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 15, Radix Codonopsis 10, Radix Scutellariae 10, Radix Glycyrrhizae Preparata 10.
Embodiment 8, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 25, Radix Codonopsis 10, Radix Scutellariae 20, Radix Glycyrrhizae Preparata 10.
Embodiment 9, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 15, Radix Codonopsis 20, Radix Scutellariae 10, Radix Glycyrrhizae Preparata 20.
Embodiment 10, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 25, Radix Codonopsis 10, Radix Scutellariae 20, Radix Glycyrrhizae Preparata 10.
Embodiment 11, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 15, Radix Codonopsis 20, Radix Scutellariae 10, Radix Glycyrrhizae Preparata 20.
Embodiment 12, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 25, Radix Codonopsis 20, Radix Scutellariae 10-20, Radix Glycyrrhizae Preparata 10.
Embodiment 13, substantially the same manner as Example 1, but have following change, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 15, Radix Codonopsis 10, Radix Scutellariae 20, Radix Glycyrrhizae Preparata 20.
Embodiment 14, substantially the same manner as Example 1, but have following change, Radix Ginseng used instead by the Radix Codonopsis in component, and Herba Taraxaci used instead by Radix Scutellariae, and Rhizoma Zingiberis uses Radix Aconiti Lateralis Preparata instead, and Rhizoma Coptidis uses Radix Curcumae instead, and Fructus Jujubae used instead by Fructus Jujubae, and Radix Puerariae uses Radix Saposhnikoviae instead.
Embodiment 15, substantially the same manner as Example 1, but have following change, Radix Pseudostellariae used instead by the Radix Codonopsis in component, and Rhizoma Coptidis uses the Radix Pulsatillae instead, and Fructus Jujubae used instead by Fructus Jujubae, and Radix Puerariae uses Rhizoma Cimicifugae instead.
Claims (4)
1. antibacterial, an antiviral swine diseases control Chinese medicine composition, it is characterized in that, the weight portion of each component is composed as follows: Rhizoma Pinelliae 15-25, Radix Codonopsis 10-20, Radix Scutellariae 10-20, Radix Glycyrrhizae Preparata 10-20, Rhizoma Zingiberis 10-20, Rhizoma Coptidis 5-10, Fructus Jujubae 10-20, Radix Puerariae 10-20;
Described each component all adopts the crude drug in whole being crushed to less than 10 μm;
The above Chinese medicine composition of described employing, with the form administration of feed additive, every pig consumption every day is 102-112g.
2. antibacterial, antiviral swine diseases control Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each component is composed as follows: Rhizoma Pinelliae 18-22, Radix Codonopsis 13-17, Radix Scutellariae 13-17, Radix Glycyrrhizae Preparata 13-17, Rhizoma Zingiberis 13-17, Rhizoma Coptidis 5-8, Fructus Jujubae 13-17, Radix Puerariae 13-17.
3. antibacterial, antiviral swine diseases control Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each component is composed as follows: the Rhizoma Pinelliae 20, Radix Codonopsis 15, Radix Scutellariae 15, Radix Glycyrrhizae Preparata 15, Rhizoma Zingiberis 15, Rhizoma Coptidis 6, Fructus Jujubae 15, Radix Puerariae 15.
4., according to antibacterial, the antiviral swine diseases control Chinese medicine composition one of claim 1-3 Suo Shu, it is characterized in that, described every pig consumption every day is 106g.
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| CN104069478A (en) * | 2014-07-26 | 2014-10-01 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104256128A (en) * | 2014-09-10 | 2015-01-07 | 兰梅 | Preparation method of horse feed additive |
| CN104256129A (en) * | 2014-09-10 | 2015-01-07 | 兰梅 | Preparation method of donkey feed additive |
| CN104258328A (en) * | 2014-09-19 | 2015-01-07 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for treating mink viral enteritis and preparation method thereof |
| CN105148223A (en) * | 2015-08-26 | 2015-12-16 | 蚌埠市蚌山区常宝养猪场 | Traditional Chinese medicine composition for preventing pig diseases and preparation method thereof |
| CN109452466A (en) * | 2018-11-20 | 2019-03-12 | 湖南诺泽生物科技有限公司 | A kind of application of composition of plant extracts in feed addictive |
| CN109453356A (en) * | 2018-12-25 | 2019-03-12 | 北京中农华正兽药有限责任公司 | A kind of Chinese medicine composition and its application method promoting animal intestines and stomach power |
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Non-Patent Citations (2)
| Title |
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| 半夏泻心汤新解;陈庆全;《新医学》;19811231;第12卷(第2期);97-98、94 * |
| 经方治疗复发性口腔溃疡的探讨;周青;《中国民族民间医药杂志》;20061231(第79期);87-88 * |
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