CN102908549A - Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu and preparation method of same - Google Patents
Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu and preparation method of same Download PDFInfo
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Abstract
The invention provides a Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu and a preparation method of the liquid. The invention provides a method that the Chinese herbal medicine fermented by beneficial bacteriums serves as feed supplements to prevent bird flu. The Chinese herbal medicine comprises the following herbals: cyrtomium fortunei, radix isatidis, membranous milkvetch root, Chinese thorowax, fructus forsythiae, coptis chinensis, honeysuckle, baical skullcap root, liquorice, folium mori, chrysanthemum morifolium ramat, platycodon root, burdock, bamboo leaf, rhizoma phragmitis, mentha haplocalyx, almond and folium eriobotryae. The Chinese herbal medicine is smashed, soaked, decocted, and fermented by the beneficial bacteriums to produce a Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu, wherein the beneficial bacteriums used during the fermentation process are mainly saccharomycete, lactic acid bacteria, photosynthetic bacteria, bifidobacterium, bacillus and the like. The Chinese herbal medicine active fermentation health care liquid has the effects of preventing and treating bird flu, promoting growth and improving chicken intestinal flora, and has the advantage that the application is easy, the dosage of Chinese herbal medicine is small, the amount of live bacterium of large and the drug residues and the resistance to drug is avoided.
Description
Technical field
The invention belongs to the microbial fermentation field of Chinese herbal medicine technology, particularly relate to a kind of Preparation method and use with high-efficiency activated health promoting liquid of preventing and treating the bird flu effect that utilizes beneficial organism flora direct fermentation vegetable Chinese herbal medicine to make.
Background technology
Bird flu (Avian influenza, AI) be the abbreviation of avian influenza, it is the infectious disease that is caused by a kind of hypotype of A type influenza virus (also claiming bird flu virus), is decided to be category A infectious disease by International Office of Epizootics, claims again fowl plague or European fowl plague.High pathogenic avian influenza harm is the most serious, and M ﹠ M is all high, and the chicken group of infection usually " is annihilated ".A type influenza virus also sees people, horse, pig, and idol is found in other mammals and the multiple birdss such as mink, sea dog and whale.The people can through respiratory tract suck disease fowl cough and eject when piping infected with the spittle of H5N1 virus, or the meat of the disease fowl of taking food and goods thereof, fowl egg, water, food that contact is polluted by sick fowl, apparatus and infected morbidity.At present, both at home and abroad the control measure of poultry bird flu are mainly comprised slaughter, sterilization, bio-safety and vaccination.The effective measures that birds flu-preventing occurs are vaccinations, when the vaccine of inoculation is consistent with clinical popular strains subtype, can obtain desirable protection effect, but the vaccine of inoculation and popular hypotype are not simultaneously, just can not protect by adaptive immune.The bird flu virus blood serum subtype is numerous, will the producer restructuring during A type influenza virus mixed infection of different subtype, forms new bird flu virus, and this development and application to vaccine brings very large difficulty.Often occur in the production practices to be unworthy of causing immuning failure because of vaccine and the epidemic isolates hypotype of inoculation.Therefore only rely on generation that avian influenza vaccine is difficult to control bird flu fully with popular, in view of this sick specific drug for the treatment of also is not developed, the antiviral chemical combination medicine of commonly using exists again and more easily produces drug resistance and the large shortcoming of side effect.And at medical domain, Chinese medicine can have been confirmed by clinical and experiment by resisiting influenza virus that the Chinese herbal medicine of energy resisiting influenza virus belongs to diaphoretic medicine and antipyretic more.Exterior syndrome is equivalent to the clinical upper respiratory tract infection of modern medicine and the symptom at infectious disease initial stage; Interior-heat syndrome then mainly comprises the various acute infectious disease of modern medicine, infectious febrile disease.Chinese herbal medicine can be relievingd asthma by diaphoresis, analgesic, sedation and analgesia, relieving cough and expelling phlegm, antiinflammatory, antiallergic, antibiotic, antiviral and promote body's immunity (diaphoretic medicine) and resisting pathogenic microbes, antibacterium toxin, antipyretic and anti-inflammatory, promotion body's immunity and anticoagulant, anti-DIC, improve the pharmacological actions such as hemorheological property, hepatic cholagogic (antipyretic) and reach the purpose of preventing and treating the influenza disease.The patent of existing herbal control bird flu all is with Chinese herbal medicine basically or directly adds in the feedstuff or take extraction, also there is Chen Peisheng (application number 200610020633.4) the Chinese medicine theory that China is traditional to combine with biotechnology, utilize the extracting solution of probiotics fermention Chinese herbal medicine, its advantage is really the active ingredient in the extracts of Chinese herbal medicine can be improved performance, fermentation produces new active substance, improve its antiviral ability, but also there is the loss of the residue active ingredient before most the filtration, total effective ingredient-use rate is low, the shortcomings such as addition height.
Summary of the invention
The objective of the invention is to overcome above-mentioned shortcoming, a kind of preparation method with high-efficiency activated health promoting liquid of preventing and treating the bird flu effect of utilizing beneficial flora direct fermentation vegetable Chinese herbal medicine to make is provided.
The Chinese herbal medicine active fermentation health promoting liquid that the present invention is used for birds flu-preventing is the basis that reaches in a large amount of investigation, design function according to product requires more than 200 kinds of Chinese herbal medicine are screened, monarch, seven emotions compatibility, eighteen incompatible medicaments, nineteen medicaments of mutual restraint scheduling theory according to traditional Chinese medicine, one by one screening and the effective component of Chinese herbal medicine, the bacteriostasis that filter out extracted, verify is finally determined prescription.From 400 multiple beneficial microorganisms, filter out 5 kinds again and can greatly improve the utilization rate of the active ingredient of Chinese herbal medicine, and produce during the fermentation multiple somatomedin probiotic bacteria.
The invention provides a kind of preparation method of Chinese herbal medicine active fermentation health promoting liquid of birds flu-preventing.Raw material by following weight portion forms: Rhizoma Osmundae 4-6 part, Radix Isatidis 4-6 part, Radix Astragali 8-12 part, Radix Bupleuri 4-6 part, Fructus Forsythiae 3-5 part, Rhizoma Coptidis 4-6 part, Flos Lonicerae 4-6 part, Radix Scutellariae 4-6 part, Radix Glycyrrhizae 3-5 part, Folium Mori 2-4 part, Flos Chrysanthemi 4-6 part, Radix Platycodonis 1-3 part, Fructus Arctii 1-2 part, Folium Bambusae 1-2 part, Rhizoma Phragmitis 1-3 part, Herba Menthae 4-6 part, Semen Armeniacae Amarum 1-3 part, Folium Eriobotryae 4-6 part, salt 1-3 part, molasses 40-60 part, salt 2-4 part, 820 parts in water, 500,000,000/ml yeast bacterium 5-15 part, 10,000,000,000/milliliter lactobacillus 5-15 part, 6,000,000,000/milliliter photosynthetic bacteria 5-15 part, 100,000,000/milliliter bacillus bifidus 5-15 part, 8,000,000,000/milliliter bacillus cereus 5-15 part, etc.
Its preparation method may further comprise the steps: mix after at first various Chinese herbal medicine powders being broken into 100 order fine powders, and add 5 times water soaking 2 hours to the Chinese herbal medicine that mixes, in soaked Chinese herbal medicine, add an amount of molasses, salt and supply again water steaming and decocting 30 minutes under 100 degree, treat that cooking liquor is cooled to 40 ℃, access 500,000,000/ml yeast bacterium 5-15 part, 10,000,000,000/milliliter lactobacillus 5-15 part, 6,000,000,000/milliliter photosynthetic bacteria 5-15 part, 100,000,000/milliliter bacillus bifidus 5-15 part, 8,000,000,000/milliliter bacillus cereus 5-15 part, 30 ℃ fermented 120-150 hours, detected its pH and were lower than 4, and viable bacteria content reaches 10
8Individual/milliliter can finish fermentation, carry out fill.
The using method of birds flu-preventing stirs for being added in the daily chicken feedstuff, and adding proportion is controlled at 0.5-1%; Cooperate drinking-water to add 0.2-0.5%, effect is better; The using method for the treatment of bird flu directly gavages, and use amount is chicken 0.2-0.5 milliliter every day, in large chicken 0.8-1.5 milliliter every day.
Excellent effect of the present invention is: in conjunction with the effect of compound probiotic and composite Chinese herbal, and energy preventing bird flu effectively and complication thereof, and good somatotrophic effect is arranged.Little ecological Studies and the poultry experience repetition test of technical scheme of the present invention by for many years forms, and meets the theory of Chinese medicine.Active fermentation health promoting liquid of the present invention contains multiple somatomedin and the probiotic bacteria that produces in the sweat, growth promoter to chicken, can effectively improve meat, improve premunition, the effect of enhancing immunity, and have and be easy to use, the Chinese herbal medicine consumption is few, and viable bacteria content is high and have noresidue, the advantage such as have no drug resistance.
The specific embodiment
Below be enforcements example more of the present invention, the actual use of the present invention is not limited to embodiment.
Embodiment 1, is used for the preparation of the probiotic bacteria Chinese herbal medicine active health liquid of birds flu-preventing
The weight proportion scope of raw material that is used for the probiotic bacteria Chinese herbal medicine active health liquid of prevention chicken infectious disease is: 5 parts of Rhizoma Osmundae, 5 parts of Radix Isatidis, 10 parts of the Radixs Astragali, 5 parts of Radix Bupleuri, 4 parts of Fructus Forsythiaes, 5 parts of Rhizoma Coptidis, 5 parts of Flos Loniceraes, 5 parts of Radix Scutellariaes, 4 parts in Radix Glycyrrhizae, 3 parts on Folium Mori, 5 parts of Flos Chrysanthemi, 2 parts of Radix Platycodoniss, 1 part of Fructus Arctii, 1 part on Folium Bambusae, 2 parts of Rhizoma Phragmitiss, 5 parts of Herba Menthaes, 2 parts in Semen Armeniacae Amarum, 5 parts of Folium Eriobotryaes, 2 parts of salt, 50 parts in molasses, 820 parts in water, 10 parts of 500,000,000/ml yeast bacterium, 10 parts of 10,000,000,000/milliliter lactobacilluss, 10 parts of 6,000,000,000/milliliter photosynthetic bacterias, 10 parts of 100,000,000/milliliter bacillus bifiduss, 10 parts of 8,000,000,000/milliliter bacillus cereuss, etc.
Its preparation method may further comprise the steps: mix after at first various Chinese herbal medicine powders being broken into 100 order fine powders, and add 5 times water soaking 2 hours to the Chinese herbal medicine that mixes, in soaked Chinese herbal medicine, add an amount of molasses, salt and supply again water steaming and decocting 30 minutes under 100 degree, treat that cooking liquor is cooled to 40 ℃, access 10 parts of 500,000,000/ml yeast bacterium, 10 parts of 10,000,000,000/milliliter lactobacilluss, 10 parts of 6,000,000,000/milliliter photosynthetic bacterias, 10 parts of 100,000,000/milliliter bacillus bifiduss, 10 parts of 8,000,000,000/milliliter bacillus cereuss, 30 ℃ fermented 120 hours, detected its pH3.5, and viable bacteria content reaches 1.2 * 10
8Individual/milliliter, finish fermentation, carry out fill.
The using method of birds flu-preventing: be added in the daily chicken feedstuff and stir, adding proportion is controlled at 0.5-1%; Cooperate drinking-water to add 0.2-0.5%, effect is better.According to experiment, in 3000 chicken feedstuffs, added 42 days, average every weightening finish 219 grams of test group contrast group, at the bird flu epidemic period, 58 morbidities of test group, protective rate 98.07%, 653 of matched group morbidities, sickness rate is 21.77%.
Embodiment 2, are used for the preparation of the probiotic bacteria Chinese herbal medicine active health liquid of control chicken infectious disease
The weight proportion scope of raw material that is used for the treatment of the probiotic bacteria Chinese herbal medicine active health liquid of chicken infectious disease is: 6 parts of Rhizoma Osmundae, 6 parts of Radix Isatidis, 12 parts of the Radixs Astragali, 6 parts of Radix Bupleuri, 5 parts of Fructus Forsythiaes, 5 parts of Rhizoma Coptidis, 6 parts of Flos Loniceraes, 6 parts of Radix Scutellariaes, 4 parts in Radix Glycyrrhizae, 3 parts on Folium Mori, 5 parts of Flos Chrysanthemi, 2 parts of Radix Platycodoniss, 1 part of Fructus Arctii, 1 part on Folium Bambusae, 2 parts of Rhizoma Phragmitiss, 5 parts of Herba Menthaes, 2 parts in Semen Armeniacae Amarum, 5 parts of Folium Eriobotryaes, 2 parts of salt, 50 parts in molasses, 820 parts in water, 10 parts of 500,000,000/ml yeast bacterium, 10 parts of 10,000,000,000/milliliter lactobacilluss, 10 parts of 6,000,000,000/milliliter photosynthetic bacterias, 10 parts of 100,000,000/milliliter bacillus bifiduss, 10 parts of 8,000,000,000/milliliter bacillus cereuss, etc.
Its preparation method may further comprise the steps: mix after at first various Chinese herbal medicine powders being broken into 100 order fine powders, and add 5 times water soaking 2 hours to the Chinese herbal medicine that mixes, in soaked Chinese herbal medicine, add an amount of molasses, salt and supply again water steaming and decocting 30 minutes under 100 degree, treat that cooking liquor is cooled to 40 ℃, access 10 parts of 500,000,000/ml yeast bacterium, 10 parts of 10,000,000,000/milliliter lactobacilluss, 10 parts of 6,000,000,000/milliliter photosynthetic bacterias, 10 parts of 100,000,000/milliliter bacillus bifiduss, 10 parts of 8,000,000,000/milliliter bacillus cereuss, 30 ℃ fermented 150 hours, detected its pH3.3, and viable bacteria content reaches 1.1 * 10
8Individual/milliliter, finish fermentation, carry out fill.
The using method for the treatment of bird flu directly gavages, and use amount is 0.3 milliliter of every day of chicken, in 1.0 milliliters of every days of large chicken.According to experiment, 405 morbidity chickens, cured 252 on 1st, cured 380 on 3rd; In 223 morbidities large chicken with it after one day effect very obvious, the full healing on the three.
Claims (7)
1. Chinese herbal medicine active fermentation health promoting liquid of preventing and treating bird flu, it is characterized in that being formed by the raw material of following weight portion: Rhizoma Osmundae 4-6 part, Radix Isatidis 4-6 part, Radix Astragali 8-12 part, Radix Bupleuri 4-6 part, Fructus Forsythiae 3-5 part, Rhizoma Coptidis 4-6 part, Flos Lonicerae 4-6 part, Radix Scutellariae 4-6 part, Radix Glycyrrhizae 3-5 part, Folium Mori 2-4 part, Flos Chrysanthemi 4-6 part, Radix Platycodonis 1-3 part, Fructus Arctii 1-2 part, Folium Bambusae 1-2 part, Rhizoma Phragmitis 1-3 part, Herba Menthae 4-6 part, Semen Armeniacae Amarum 1-3 part, Folium Eriobotryae 4-6 part, salt 1-3 part, molasses 40-60 part, salt 2-4 part, 820 parts in water, 500,000,000/ml yeast bacterium 5-15 part, 10,000,000,000/milliliter lactobacillus 5-15 part, 6,000,000,000/milliliter photosynthetic bacteria 5-15 part, 100,000,000/milliliter bacillus bifidus 5-15 part, 8,000,000,000/milliliter bacillus cereus 5-15 part, etc.; Said herbal medicine is made the Chinese herbal medicine active-fermented broth of birds flu-preventing through pulverizing, soak, decoct, fermenting.
2. the Chinese herbal medicine active fermentation health promoting liquid of control bird flu according to claim 1 is characterized in that, pulverizing is just to mix after various Chinese herbal medicine powders are broken into 100 order fine powders.
3. the Chinese herbal medicine active fermentation health promoting liquid of birds flu-preventing according to claim 1 is characterized in that, immersion be will mix Chinese herbal medicine add 5 times water soaking 2 hours.
4. the Chinese herbal medicine active fermentation health promoting liquid of birds flu-preventing according to claim 1, it is characterized in that steaming and decocting is Chinese herbal medicine and the desired molasses of claim 1, the salt that claim 4 is soaked and supplies right 1 and require the steaming and decocting 30 minutes under 100 degree of corresponding water.
5. the Chinese herbal medicine active fermentation health promoting liquid of birds flu-preventing according to claim 1, it is characterized in that, fermentation is with the liquid cools to 40 of right 5 steaming and decoctings ℃, the 500000000/ml yeast bacterium 5-15 part in the access claim 1,10,000,000,000/milliliter lactobacillus 5-15 part, 6,000,000,000/milliliter photosynthetic bacteria 5-15 part, 100,000,000/milliliter bacillus bifidus 5-15 part, 8,000,000,000/milliliter bacillus cereus 5-15 part, 30 ℃ fermented 120-150 hours, detect its pH and be lower than 4, viable bacteria content reaches 10
8Individual/milliliter, can finish fermentation.
6. a preparation method of preventing and treating the Chinese herbal medicine active fermentation health promoting liquid of bird flu is characterized in that, the using method of birds flu-preventing stirs for being added in the daily chicken feedstuff, and adding proportion is controlled at 0.5%-1%; Cooperate drinking-water to add 0.2%-0.5%, effect is better.
7. a preparation method of preventing and treating the Chinese herbal medicine active fermentation health promoting liquid of bird flu is characterized in that, the using method for the treatment of bird flu directly gavages, and use amount is chicken 0.2-0.5 milliliter every day, in large chicken 0.8-1.5 milliliter every day.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210454545.0A CN102908549B (en) | 2012-11-14 | 2012-11-14 | Preparation method of Chinese herbal medicine active fermentation health care liquid for preventing and treating bird flu |
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| CN103859156A (en) * | 2014-04-01 | 2014-06-18 | 山东新希望六和集团有限公司 | Feed for controlling duck pulp conjunctivitis, Chinese medicine composition and preparation method |
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| CN103141683A (en) * | 2013-03-06 | 2013-06-12 | 魏放 | Composite pig feed containing Chinese medicinal herbs |
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| CN103859156A (en) * | 2014-04-01 | 2014-06-18 | 山东新希望六和集团有限公司 | Feed for controlling duck pulp conjunctivitis, Chinese medicine composition and preparation method |
| CN103859168A (en) * | 2014-04-03 | 2014-06-18 | 常熟理工学院 | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof |
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| CN105617367A (en) * | 2014-11-04 | 2016-06-01 | 孙文彬 | Livestock and poultry respiratory tract health promotion ferment and preparation method thereof |
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| CN104644538A (en) * | 2015-01-23 | 2015-05-27 | 四川省中医药科学院 | Scutellaria baicalensis and lactic acid bacteria yeasts, cosmetics containing yeasts, preparation method and application |
| CN104644538B (en) * | 2015-01-23 | 2017-09-26 | 四川省中医药科学院 | Radix scutellariae lactobacillus fermentation, the cosmetics containing fermentate and preparation method and purposes |
| CN105519518A (en) * | 2015-04-08 | 2016-04-27 | 上海蓝盎电子科技发展有限公司 | Chinese herbal medicine bacterial fermentation product-containing eco-friendly harmless pathological tissue preservation and treatment solution |
| CN105168337A (en) * | 2015-08-27 | 2015-12-23 | 格特生物制药（天津）有限公司 | Fermentation traditional Chinese medicine preparation treating chick bird flu |
| CN105146162A (en) * | 2015-08-28 | 2015-12-16 | 安徽旺旺禽业科技有限公司 | Chick feed additive prepared by comprehensively using coconut shell and capable of improving intestinal health |
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| CN105341487A (en) * | 2015-11-22 | 2016-02-24 | 衡阳市富矿饲料添加剂有限公司 | Chinese herbal medicinal premixed feed for preventing avian influenza of chickens, and preparation method thereof |
| CN105477417A (en) * | 2015-12-18 | 2016-04-13 | 信宜市粤丰种养专业合作社 | Traditional Chinese medicine preparation for preventing and treating avian influenza of broilers and preparation method of stoste |
| CN105981984A (en) * | 2016-03-07 | 2016-10-05 | 倪皖生 | Layer feed capable of preventing avian influenza and preparation method thereof |
| CN106071306A (en) * | 2016-06-16 | 2016-11-09 | 漳州红点商务咨询有限公司 | Chicken feed processing technology |
| CN106215011A (en) * | 2016-08-29 | 2016-12-14 | 佛山市艳晖生物科技有限公司 | A kind of preparation method of the Chinese herbal medicinal active fermentation broth preventing swine fever |
| CN106511675A (en) * | 2016-11-08 | 2017-03-22 | 广西罗城新科双全有机食品有限公司 | Medicine for preventing and treating poultry diseases and preparation method of medicine |
| CN110279817A (en) * | 2019-07-16 | 2019-09-27 | 广西富凤农牧集团有限公司 | A kind of fermented tcm additive and preparation method thereof for preventing and treating fowl respiratory disease |
| CN111249337A (en) * | 2020-01-15 | 2020-06-09 | 河南天昊鸿发生物技术有限公司 | Microecological preparation for treating respiratory diseases of livestock and poultry and preparation method thereof |
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