CN103027955A - Granules for preventing and treating chicken infectious bursal disease and preparation method thereof - Google Patents
Granules for preventing and treating chicken infectious bursal disease and preparation method thereof Download PDFInfo
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- CN103027955A CN103027955A CN 201110298393 CN201110298393A CN103027955A CN 103027955 A CN103027955 A CN 103027955A CN 201110298393 CN201110298393 CN 201110298393 CN 201110298393 A CN201110298393 A CN 201110298393A CN 103027955 A CN103027955 A CN 103027955A
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Abstract
The invention discloses granules for preventing and treating a chicken infectious bursal disease and a preparation method thereof. The granules for preventing and treating the chicken infectious bursal disease are prepared from 10 to 50g of fructus forsythia, 10 to 30g of radix isatidis, 20 to 50g of flos lonicerae, 10 to 30g of radix scutellariae, and 20 to 50g of radix astragali. The granules for preventing and treating the chicken infectious bursal disease can effectively prevent and treat the infectious bursal disease of poultry, enhance the immunity for the poultry, and clear away heat and toxic materials. Compared with the prior art, the granules for preventing and treating the chicken infectious bursal disease provided by the invention are simple in compatibility, good in efficacy, and convenient to use, and the reasonable and feasible preparation method is provided.
Description
Technical field: the present invention is a kind of granule of preventing and treating infectious bursal disease and preparation method thereof, belongs to the technical field of medicine.
Technical background: infectious bursal disease be by infectious bursa of Fabricius virus cause take destroy chicken central immune organ---fabricius bursa is as main pathogenetic viral infectious, cause the humoral immunization failure of poultry, the morbidity age in days more early, immunosuppressant is more serious, and can affect the later health level of poultry.This disease was made a definite diagnosis in the Gan Baoluozhen of the Delaware State, east coast of the united states first in nineteen fifty-seven, therefore was referred to as again sweet Borrow sick (gumborodisease).The harm of this disease not only makes the direct economic losses such as chicken is dead, mortality increases, impact weightening finish, the more important thing is virus damage fabricius bursa and cause immunosuppressant, make the disease chicken to the cause of diseases such as escherichia coli, Salmonella, chicken coccidiosis susceptible more, the immunne response of the immunity inoculations such as horse Garrick vaccine, newcastle disease vaccine is descended or forfeiture.Primary disease incubation period is 2～3 days, and the susceptible chicken group infects rear sudden onset, and generally about a week, typical case's morbidity chicken group's death curve is the spike formula to the course of disease.Sick just visible indivedual chicken sudden onset, lassitude can involve full group in 1～2 day, spirit is depressed, appetite descends, and feather is fluffy, and wing is sagging, closing order dozes off, diarrhoea is discharged white loose stool or Ovum Gallus domesticus album sample loose stool, contains microlith ash slag specimen thing, be the Calx sample after dry, feather is seriously polluted around the anus; Fear of cold, crowded heap, severe patient is hung one's head, is thrown oneself on the ground, serious dehydration, extremely feeble, the to external world blunt or disappearance of irritant reaction, later stage temperature decline.1～2 day sick chicken death rate showed increased and linearly rising after the morbidity reached peak mortality, and descended rapidly thereafter in 5～7 days.Bursal disease has imported into from the end of the seventies since China, has formed several times popular outburst in China, brings about great losses for the poultry husbandry of China, becomes three large epidemic diseases with Marek, newcastle harm poultry husbandry arranged side by side.In recent years because optionally variation occurs in the deterioration of China's breeding environment and infectious bursal disease virus under the effect of living environment and immune pressure, make bursal disease some new variations occur, the scale raising that causes some infectious bursal disease immunizations to be done well also constantly occurs popular, increase the difficulty of control, the symptom of a trend of scale outburst occurred.Although infectious bursal disease is popular very wide in China, in the family of much raising chickens generation is arranged all, without special effect medicine therapeutic.The curative effect of the Western medicine such as oresol drinking-water, vitamin C, the spirit of sick Seedling, Diverdine is all undesirable.
This shows that infectious bursal disease is a kind of acute, the height contagious disease of harm chickling, brings serious economic loss to poultry husbandry.For this situation, develop a kind of safe and effective, the thing that the little Chinese medicine preparation of side effect has just become people to be badly in need of solving.
Summary of the invention:
The object of the invention is to: a kind of granule of preventing and treating infectious bursal disease and preparation method thereof is provided; The present invention is directed to prior art, the granulation agent such as Fructus Forsythiae, Radix Isatidis is not only easy to use, and also craft science is reasonable, can better keep effective ingredient, and therapeutical effect is good, extensive market.
The present invention consists of like this: it is to be made by Fructus Forsythiae 10-50g, Radix Isatidis 10-30g, Flos Lonicerae 20-50g, Radix Scutellariae 10-30g, Radix Astragali 20-50g.Be preferably: Fructus Forsythiae 30g, Radix Isatidis 20g, Flos Lonicerae 30g, Radix Scutellariae 15g, Radix Astragali 30g.
The preparation method of described granule: get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 6-12 times of water gaging, decoct 1-3 time, each 1-3 hour, merge decoction liquor, filter, concentrated, add ethanol and transfer to and contain alcohol amount 50-80%, and regulate pH value, cold preservation, filter, filtrate recycling ethanol adds adjuvant and granulates to the thick paste shape, drying, the granulate packing.Be preferably: get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 10 times of water gagings, decoct 3 times, each 2 hours, merge decoction liquor, filter, concentrated by 1: 1, add ethanol and transfer to and contain alcohol amount 60%, and to regulate pH be 8, cold preservation is filtered, and filtrate recycling ethanol is to the thick paste shape, added dextrin by 1: 2, soft material processed is crossed 12 mesh sieves and is granulated, 60 ℃ of dryings, the granulate packing.
Infectious bursal disease claims again infectious bursal disease, is a kind of acute, the social disease that is caused by infectious bursa of Fabricius virus.Be badly damaged as feature take fabricius bursa inflammation, necrosis, atrophy and fabricius bursa endolymph cell, thereby cause the immunodeficiency disease of chicken, disturb the immune effect of various vaccines.Sickness rate is high, almost reaches 100%, and mortality rate is generally 5%～15%.This is a kind of viral infectious of a class height contact and main harm children chicken, and avian health and life in serious threat.But owing to vaccine high strength, on a large scale use, so that the difficulty of control increases.Chinese herbal treatment should disease, and it is abundant, cheap to have a medicine source, and toxic and side effects is little, and the advantage such as have no drug resistance and medicine is residual.At present, except using vaccine and yolk antibody, hyper-immune serum to prevent and treating, use the Chinese herb prevention infectious bursal disease and demonstrate wide prospect, become the focus of research.
Adopt Chinese herb prevention man poultry infectious bursal disease, the basis of medication is heat-clearing and toxic substances removing, enhancing immunity.Fructus Forsythiae has another name called that Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc., and fruit medicine is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of heating, laryngopharynx swelling and pain, and acute nephritiss etc. have antibiotic, heart tonifying, diuresis, town and the pharmacological action such as tell.Radix Isatidis is divided into northern Radix Isatidis and Rhizoma Et Radix Baphicacanthis Cusiae, and northern Radix Isatidis source is the root of cruciferae isatis and careless Folium Isatidis; Rhizoma Et Radix Baphicacanthis Cusiae is rhizome and the root of acanthaceous vegetable acanthaceous indigo.Have the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving, modern pharmacology studies confirm that it has antibiosis and antiviral functions.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and such as fever of the body, dermexanthesis, send out the cards such as speckle, laryngopharynx swelling and pain, all effect is remarkable, and modern pharmacology research finds that various pathogens is had certain inhibitory action.Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic good, has the strong characteristics of broad-spectrum antibacterial action, and does not develop immunity to drugs.The Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The medicinal so far history in existing more than 2000 year of the Radix Astragali, modern study, the Radix Astragali contain the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.The enhancing human body immunity function arranged, protect the liver, diuresis, anti-stress, blood pressure lowering and antibacterial action more widely.
The ultimate principle that Chinese medicine is prevented and treated disease is strengthening vital QI to eliminate pathogenic factors, eliminates paathogenic factor, the resistance against diseases of enhancing body, and the effect of we aspect resisting pathogenic microbes also is like this.Radix Scutellariae can pathogenic fire purging, and Qinghua is damp and hot.Studies show that various bioactivators such as containing berberine, baicalin in the Radix Scutellariae, the metabolite of these materials can viral interference DNA or the copying of RNA, and suppresses the synthetic of viral nucleic acid and coat protein, can fundamentally suppress the propagation of virus; Flos Lonicerae not only has stronger antibacterial action, and can strengthen the density of blood capillary, prevent the hemorrhage and subcutaneous hemorrhage of capillary rupture, therefore, the compatibilities such as Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae have stronger antibiotic, antiviral, increase phagocyte quantity, improve cytophagous phagocytic function, and can stop virus to erythrocytic damage, improve the ability of CIC in red blood cell adhesion, the removing blood, fundamentally improve erythrocyte immune function.
This product extracts effectively minute with decoction and alcohol sedimentation technique, investigated 3 kinds of varying levels of decocting time, alcohol precipitation concentration, these 3 factors of alcoholic solution acid-base value (pH) to the impact of extracts active ingredients.Determine with alkaline alcohol deposition method effective component extracting at last, both improved the extracts active ingredients amount, can effectively remove the impurity such as protein, tannin in the medical material again.
This product antagonism immunosuppressant has immunological enhancement, and the enhancing body resistance can make its spleen, thymic weight obviously increase, and increases the quantity of T cell, and the energy enhancing antibody forms, the propagation of activated lymphocyte; Can stimulate and inducement interferon (especially alpha-interferon) simultaneously, strengthen the physiologically active of immunocyte, make body produce antiviral protein, suppress the nucleic acid replication of virus, produce antiviral effect, hepatoprotective, heart tonifying spleen invigorating, it is pleasant to relieving asthma, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema; Alleviate the secondary injury of infection cell; Blood glucose in the control agent promotes growth.
Concrete embodiment:
Embodiments of the invention 1:
Fructus Forsythiae 30g, Radix Isatidis 20g, Flos Lonicerae 30g, Radix Scutellariae 15g, Radix Astragali 30g
Get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 10 times of water gagings, decoct 3 times, each 2 hours, merge decoction liquor, filter, concentrated by 1: 1, add ethanol and transfer to and contain alcohol amount 60%, and to regulate pH be 8, cold preservation is filtered, and filtrate recycling ethanol is to the thick paste shape, added dextrin by 1: 2, soft material processed is crossed 12 mesh sieves and is granulated, 60 ℃ of dryings, the granulate packing namely gets granule.
During use, with clear water granule is dissolved, certainly drinks for chicken.
Embodiments of the invention 2:
Fructus Forsythiae 10g, Radix Isatidis 10g, Flos Lonicerae 20g, Radix Scutellariae 10g, Radix Astragali 20g
Get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 6 times of water gagings, decocted 1 hour, decoction liquor filters, and is concentrated, add ethanol and transfer to the alcohol amount of containing 50%, and regulate pH value, cold preservation is filtered, filtrate recycling ethanol adds adjuvant and granulates drying, granulate packing to the thick paste shape.
Embodiments of the invention 3:
Fructus Forsythiae 50g, Radix Isatidis 30g, Flos Lonicerae 50g, Radix Scutellariae 30g, Radix Astragali 50g
Get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 12 times of water gagings, decoct 3 times, each-3 hours, merge decoction liquor, filter, concentrated, add ethanol and transfer to and contain alcohol amount 80%, and regulate pH value, cold preservation, filter, filtrate recycling ethanol adds adjuvant and granulates drying, granulate packing to the thick paste shape.
Claims (4)
1. granule of preventing and treating infectious bursal disease, it is characterized in that: it is to be made by Fructus Forsythiae 10-50g, Radix Isatidis 10-30g, Flos Lonicerae 20-50g, Radix Scutellariae 10-30g, Radix Astragali 20-50g.
2. according to the granule of control infectious bursal disease claimed in claim 1, it is characterized in that: it is to be made by Fructus Forsythiae 30g, Radix Isatidis 20g, Flos Lonicerae 30g, Radix Scutellariae 15g, Radix Astragali 30g.
3. according to the preparation method of the granule of claim 1 or 2 described control infectious bursal diseases, it is characterized in that: get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 6-12 times of water gaging, decoct 1-3 time, each 1-3 hour, merge decoction liquor, filter, concentrated, add ethanol and transfer to and contain alcohol amount 50-80%, and the adjusting pH value, cold preservation is filtered, filtrate recycling ethanol is to the thick paste shape, add adjuvant and granulate drying, granulate packing.
4. according to the preparation method of the granule of control infectious bursal disease claimed in claim 3, it is characterized in that: get Fructus Forsythiae, Radix Isatidis, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, add 10 times of water gagings, decoct 3 times, each 2 hours, merge decoction liquor, filter, concentrated by 1: 1, add ethanol and transfer to the alcohol amount 60% that contains, and to regulate pH be 8, and cold preservation is filtered, filtrate recycling ethanol is to the thick paste shape, by 1: 2 adding dextrin, soft material processed, cross 12 mesh sieves and granulate 60 ℃ of dryings, granulate packing.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859168A (en) * | 2014-04-03 | 2014-06-18 | 常熟理工学院 | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof |
| CN104288554A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese veterinary medicine injection for treating infectious bursal disease and preparation method thereof |
| CN109498718A (en) * | 2018-12-07 | 2019-03-22 | 沈阳农业大学 | A kind of dedicated herbal mixture of broiler chicken and its manufacture craft |
-
2011
- 2011-09-30 CN CN 201110298393 patent/CN103027955A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103859168A (en) * | 2014-04-03 | 2014-06-18 | 常熟理工学院 | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof |
| CN104288554A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese veterinary medicine injection for treating infectious bursal disease and preparation method thereof |
| CN109498718A (en) * | 2018-12-07 | 2019-03-22 | 沈阳农业大学 | A kind of dedicated herbal mixture of broiler chicken and its manufacture craft |
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Application publication date: 20130410 |